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Steven Jacobs

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

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Chromatin

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Publications

TOP 3
Steven Jacobs; Jinquan Luo; Thomas Malia; Galina Obmolova; Michael D Diem; Gary L Gilliland; Alexey Teplyakov; Karyn T O'Neil
Design of novel FN3 domains with high stability by a consensus sequence approach.
Sheng-Jiun Wu; Jinquan Luo; Karyn T O'Neil; James Kang; Eilyn R Lacy; Gabriela Canziani; Audrey Baker; Maggie Huang; Qing Mike Tang; T Shantha Raju; Steven Jacobs; Alexey Teplyakov; Gary L Gilliland; Yiqing Feng
Structure-based engineering of a monoclonal antibody for improved solubility.
Steven Jacobs; Sheng-Jiun Wu; Yiqing Feng; Deidra Bethea; Karyn T O'Neil
Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates.

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All Publications

2012: Steven Jacobs; Jinquan Luo; Thomas Malia; Galina Obmolova; Michael D Diem; Gary L Gilliland; Alexey Teplyakov; Karyn T O'Neil
Design of novel FN3 domains with high stability by a consensus sequence approach.
Protein engineering, design & selection : PEDS 2012;25(3):107-17.
2010: Sheng-Jiun Wu; Jinquan Luo; Karyn T O'Neil; James Kang; Eilyn R Lacy; Gabriela Canziani; Audrey Baker; Maggie Huang; Qing Mike Tang; T Shantha Raju; Steven Jacobs; Alexey Teplyakov; Gary L Gilliland; Yiqing Feng
Structure-based engineering of a monoclonal antibody for improved solubility.
Protein engineering, design & selection : PEDS 2010;23(8):643-51.
2010: Steven Jacobs; Sheng-Jiun Wu; Yiqing Feng; Deidra Bethea; Karyn T O'Neil
Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates.
Pharmaceutical research 2010;27(1):65-71.
2008: Wolfgang Fischle; Henriette Franz; Steven Jacobs; C David Allis; Sepideh Khorasanizadeh
Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs.
The Journal of biological chemistry 2008;283(28):19626-35.
2006: Steven Jacobs; Elaine R Podell; Thomas R Cech
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Nature structural & molecular biology 2006;13(3):218-25.
2005: Steven Jacobs; Elaine R Podell; Deborah S Wuttke; Thomas R Cech
Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Protein science : a publication of the Protein Society 2005;14(8):2051-8.
2004: Steven Jacobs; Wolfgang Fischle; Sepideh Khorasanizadeh
Assays for the determination of structure and dynamics of the interaction of the chromodomain with histone peptides.
Methods in enzymology 2004;376():131-48.
2003: Wolfgang Fischle; Yanming Wang; Steven Jacobs; Youngchang Kim; C David Allis; Sepideh Khorasanizadeh
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.
Genes & development 2003;17(15):1870-81.
2002: Steven Jacobs; Joel M Harp; Srikripa Devarakonda; Youngchang Kim; Fraydoon Rastinejad; Sepideh Khorasanizadeh
The active site of the SET domain is constructed on a knot.
Nature structural biology 2002;9(11):833-8.
2002: Steven Jacobs; Sepideh Khorasanizadeh
Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail.
Science (New York, N.Y.) 2002;295(5562):2080-3.
2001: Steven Jacobs; SEAN TAVERNA; Yi Zhang; Scott D Briggs; J Li; Joel C Eissenberg; C David Allis; Sepideh Khorasanizadeh
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3.
The EMBO journal 2001;20(18):5232-41.
2001: Xiong Yu; Steven Jacobs; Stephen C West; T Ogawa; Edward H Egelman
Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8419-24.