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Thomas Buckley

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
13
van der Goot, Gisou
10
Nelson, KL
10
Parker, Michael
10
Pattus, Franc
5
Brodsky, Robert
4
Rossjohn, Jamie
4
Diep, DB
4
Mukhina, Galina
3
Raja, SM
3
Brumlik, Michael
3
Ausio, J
3
Howard, SP
3
Jones, Richard
3
Lawrence, TS
3
Tweten, Rodney

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Publications

TOP 3
Hu Rong; Mukhina Galina L; Lee Soo Hee; Jones Richard J; Englund Paul T; Brown Patrick; Sharkis Saul J; Buckley J Thomas; Brodsky Robert A
Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma.
Melton Jody A; Parker Michael W; Rossjohn Jamie; Buckley J Thomas; Tweten Rodney K
The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin.
Mukhina G L; Buckley J T; Barber J P; Jones R J; Brodsky R A
Multilineage glycosylphosphatidylinositol anchor-deficient haematopoiesis in untreated aplastic anaemia.

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All Publications

2009: Hu Rong; Mukhina Galina L; Lee Soo Hee; Jones Richard J; Englund Paul T; Brown Patrick; Sharkis Saul J; Buckley J Thomas; Brodsky Robert A
Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma.
Experimental hematology 2009;37(4):423-434.e2.
2004: Melton Jody A; Parker Michael W; Rossjohn Jamie; Buckley J Thomas; Tweten Rodney K
The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin.
The Journal of biological chemistry 2004;279(14):14315-22.
2001: Mukhina G L; Buckley J T; Barber J P; Jones R J; Brodsky R A
Multilineage glycosylphosphatidylinositol anchor-deficient haematopoiesis in untreated aplastic anaemia.
British journal of haematology 2001;115(2):476-82.
2001: Burr S E; Diep D B; Buckley J T
Type II secretion by Aeromonas salmonicida: evidence for two periplasmic pools of proaerolysin.
Journal of bacteriology 2001;183(20):5956-63.
2001: Barry R; Moore S; Alonso A; Ausió J; Buckley J T
The channel-forming protein proaerolysin remains a dimer at low concentrations in solution.
The Journal of biological chemistry 2001;276(1):551-4.
2000: Alonso A; Goñi F M; Buckley J T
Lipids favoring inverted phase enhance the ability of aerolysin to permeabilize liposome bilayers.
Biochemistry 2000;39(46):14019-24.
2000: Brodsky R A; Mukhina G L; Li S; Nelson K L; Chiurazzi P L; Buckley J T; Borowitz M J
Improved detection and characterization of paroxysmal nocturnal hemoglobinuria using fluorescent aerolysin.
American journal of clinical pathology 2000;114(3):459-66.
2000: Nelson K L; Buckley J T
Channel formation by the glycosylphosphatidylinositol-anchored protein binding toxin aerolysin is not promoted by lipid rafts.
The Journal of biological chemistry 2000;275(26):19839-43.
1999: Gordon V M; Nelson K L; Buckley J T; Stevens V L; Tweten R K; Elwood P C; Leppla S H
Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.
The Journal of biological chemistry 1999;274(38):27274-80.
1999: Nelson K L; Brodsky R A; Buckley J T
Channels formed by subnanomolar concentrations of the toxin aerolysin trigger apoptosis of T lymphomas.
Cellular microbiology 1999;1(1):69-74.
1999: Brodsky R A; Mukhina G L; Nelson K L; Lawrence T S; Jones R J; Buckley J T
Resistance of paroxysmal nocturnal hemoglobinuria cells to the glycosylphosphatidylinositol-binding toxin aerolysin.
Blood 1999;93(5):1749-56.
1999: Diep D B; Nelson K L; Lawrence T S; Sellman B R; Tweten R K; Buckley J T
Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein.
Molecular microbiology 1999;31(3):785-94.
1999: Buckley J T; Howard S P
The cytotoxic enterotoxin of Aeromonas hydrophila is aerolysin.
Infection and immunity 1999;67(1):466-7.
1998: Abrami L; Fivaz M; Decroly E; Seidah N G; Jean F; Thomas G; Leppla S H; Buckley J T; van der Goot F G
The pore-forming toxin proaerolysin is activated by furin.
The Journal of biological chemistry 1998;273(49):32656-61.
1998: Diep D B; Lawrence T S; Ausio J; Howard S P; Buckley J T
Secretion and properties of the large and small lobes of the channel-forming toxin aerolysin.
Molecular microbiology 1998;30(2):341-52.
1998: Diep D B; Nelson K L; Raja S M; Pleshak E N; Buckley J T
Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin.
The Journal of biological chemistry 1998;273(4):2355-60.
1998: Rossjohn J; Raja S M; Nelson K L; Feil S C; van der Goot F G; Parker M W; Buckley J T
Movement of a loop in domain 3 of aerolysin is required for channel formation.
Biochemistry 1998;37(2):741-6.
1998: Rossjohn J; Feil S C; McKinstry W J; Tsernoglou D; van der Goot G; Buckley J T; Parker M W
Aerolysin--a paradigm for membrane insertion of beta-sheet protein toxins?
Journal of structural biology 1998;121(2):92-100.
1997: Cabiaux V; Buckley J T; Wattiez R; Ruysschaert J M; Parker M W; van der Goot F G
Conformational changes in aerolysin during the transition from the water-soluble protoxin to the membrane channel.
Biochemistry 1997;36(49):15224-32.
1997: Cowell S; Aschauer W; Gruber H J; Nelson K L; Buckley J T
The erythrocyte receptor for the channel-forming toxin aerolysin is a novel glycosylphosphatidylinositol-anchored protein.
Molecular microbiology 1997;25(2):343-50.
1997: Rossjohn J; Buckley J T; Hazes B; Murzin A G; Read R J; Parker M W
Aerolysin and pertussis toxin share a common receptor-binding domain.
The EMBO journal 1997;16(12):3426-34.
1997: Brumlik M J; van der Goot F G; Wong K R; Buckley J T
The disulfide bond in the Aeromonas hydrophila lipase/acyltransferase stabilizes the structure but is not required for secretion or activity.
Journal of bacteriology 1997;179(10):3116-21.
1997: Nelson K L; Raja S M; Buckley J T
The glycosylphosphatidylinositol-anchored surface glycoprotein Thy-1 is a receptor for the channel-forming toxin aerolysin.
The Journal of biological chemistry 1997;272(18):12170-4.
1997: Letellier L; Howard S P; Buckley J T
Studies on the energetics of proaerolysin secretion across the outer membrane of Aeromonas species. Evidence for a requirement for both the protonmotive force and ATP.
The Journal of biological chemistry 1997;272(17):11109-13.
1996: Moniatte M; van der Goot F G; Buckley J T; Pattus F; van Dorsselaer A
Characterisation of the heptameric pore-forming complex of the Aeromonas toxin aerolysin using MALDI-TOF mass spectrometry.
FEBS letters 1996;384(3):269-72.
1996: Brumlik M J; Buckley J T
Identification of the catalytic triad of the lipase/acyltransferase from Aeromonas hydrophila.
Journal of bacteriology 1996;178(7):2060-4.
1996: Parker M W; van der Goot F G; Buckley J T
Aerolysin--the ins and outs of a model channel-forming toxin.
Molecular microbiology 1996;19(2):205-12.
1995: Buckley J T; Wilmsen H U; Lesieur C; Schulze A; Pattus F; Parker M W; van der Goot F G
Protonation of histidine-132 promotes oligomerization of the channel-forming toxin aerolysin.
Biochemistry 1995;34(50):16450-5.
1995: Brick D J; Brumlik M J; Buckley J T; Cao J X; Davies P C; Misra S; Tranbarger T J; Upton C
A new family of lipolytic plant enzymes with members in rice, arabidopsis and maize.
FEBS letters 1995;377(3):475-80.
1995: Hardie K R; Schulze A; Parker M W; Buckley J T
Vibrio spp. secrete proaerolysin as a folded dimer without the need for disulphide bond formation.
Molecular microbiology 1995;17(6):1035-44.
1994: Gruber H J; Wilmsen H U; Cowell S; Schindler H; Buckley J T
Partial purification of the rat erythrocyte receptor for the channel-forming toxin aerolysin and reconstitution into planar lipid bilayers.
Molecular microbiology 1994;14(5):1093-101.
1994: van der Goot F G; Hardie K R; Parker M W; Buckley J T
The C-terminal peptide produced upon proteolytic activation of the cytolytic toxin aerolysin is not involved in channel formation.
The Journal of biological chemistry 1994;269(48):30496-501.
1994: van der Goot F G; Pattus F; Parker M; Buckley J T
The cytolytic toxin aerolysin: from the soluble form to the transmembrane channel.
Toxicology 1994;87(1-3):19-28.
1994: Robertson D L; Hilton S; Wong K R; Koepke A; Buckley J T
Influence of active site and tyrosine modification on the secretion and activity of the Aeromonas hydrophila lipase/acyltransferase.
The Journal of biological chemistry 1994;269(3):2146-50.
1994: Parker M W; Buckley J T; Postma J P; Tucker A D; Leonard K; Pattus F; Tsernoglou D
Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states.
Nature 1994;367(6460):292-5.
1993: Ausio J; van der Goot F G; Buckley J T
Physical and chemical characterization of the oligomerization state of the Aeromonas hydrophila lipase/acyltransferase.
FEBS letters 1993;333(3):296-300.
1993: Wong K R; Buckley J T
Aeromonas spp. can secrete Escherichia coli alkaline phosphatase into the culture supernatant, and its release requires a functional general secretion pathway.
Molecular microbiology 1993;9(5):955-63.
1993: van der Goot F G; Ausio J; Wong K R; Pattus F; Buckley J T
Dimerization stabilizes the pore-forming toxin aerolysin in solution.
The Journal of biological chemistry 1993;268(24):18272-9.
1993: van der Goot F G; Pattus F; Wong K R; Buckley J T
Oligomerization of the channel-forming toxin aerolysin precedes insertion into lipid bilayers.
Biochemistry 1993;32(10):2636-42.
1992: Jeanteur D; Gletsu N; Pattus F; Buckley J T
Purification of Aeromonas hydrophila major outer-membrane proteins: N-terminal sequence analysis and channel-forming properties.
Molecular microbiology 1992;6(22):3355-63.
1992: Buckley J T
The channel-forming toxin aerolysin.
FEMS microbiology immunology 1992;5(1-3):13-7.
1992: van der Goot F G; Lakey J; Pattus F; Kay C M; Sorokine O; Van Dorsselaer A; Buckley J T
Spectroscopic study of the activation and oligomerization of the channel-forming toxin aerolysin: identification of the site of proteolytic activation.
Biochemistry 1992;31(36):8566-70.
1992: Buckley J T
Crossing three membranes. Channel formation by aerolysin.
FEBS letters 1992;307(1):30-3.
1992: Wilmsen H U; Leonard K R; Tichelaar W; Buckley J T; Pattus F
The aerolysin membrane channel is formed by heptamerization of the monomer.
The EMBO journal 1992;11(7):2457-63.
1992: Robertson D L; Hilton S; Buckley J T
Stereochemical and positional specificity of the lipase/acyltransferase produced by Aeromonas hydrophila.
Biochemistry 1992;31(21):4974-80.
1991: Wilmsen H U; Buckley J T; Pattus F
Site-directed mutagenesis at histidines of aerolysin from Aeromonas hydrophila: a lipid planar bilayer study.
Molecular microbiology 1991;5(11):2745-51.
1991: Wong K R; Buckley J T
Site-directed mutagenesis of a single tryptophan near the middle of the channel-forming toxin aerolysin inhibits its transfer across the outer membrane of Aeromonas salmonicida.
The Journal of biological chemistry 1991;266(22):14451-6.
1991: Hilton S; Buckley J T
Action of a microbial lipase/acyltransferase on phospholipid monolayers.
Biochemistry 1991;30(24):6070-4.
1991: Buckley J T
Secretion and mechanism of action of the hole-forming toxin aerolysin.
Experientia 1991;47(5):418-9.
1991: Hilton S; Buckley J T
Studies on the reaction mechanism of a microbial lipase/acyltransferase using chemical modification and site-directed mutagenesis.
The Journal of biological chemistry 1991;266(2):997-1000.
1990: Hilton S; McCubbin W D; Kay C M; Buckley J T
Purification and spectral study of a microbial fatty acyltransferase: activation by limited proteolysis.
Biochemistry 1990;29(38):9072-8.
1990: Tucker A D; Parker M W; Tsernoglou D; Buckley J T
Crystallization of a proform of aerolysin, a hole-forming toxin from Aeromonas hydrophila.
Journal of molecular biology 1990;212(4):561-2.
1990: Wilmsen H U; Pattus F; Buckley J T
Aerolysin, a hemolysin from Aeromonas hydrophila, forms voltage-gated channels in planar lipid bilayers.
The Journal of membrane biology 1990;115(1):71-81.
1990: Green M J; Buckley J T
Site-directed mutagenesis of the hole-forming toxin aerolysin: studies on the roles of histidines in receptor binding and oligomerization of the monomer.
Biochemistry 1990;29(8):2177-80.
1990: Wong K R; McLean D M; Buckley J T
Cloned aerolysin of Aeromonas hydrophila is exported by a wild-type marine Vibrio strain but remains periplasmic in pleiotropic export mutants.
Journal of bacteriology 1990;172(1):372-6.
1990: Buckley J T
Purification of cloned proaerolysin released by a low protease mutant of Aeromonas salmonicida.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(1):221-4.
1989: Wong K R; Buckley J T
Proton motive force involved in protein transport across the outer membrane of Aeromonas salmonicida.
Science (New York, N.Y.) 1989;246(4930):654-6.
1989: Wong K R; Green M J; Buckley J T
Extracellular secretion of cloned aerolysin and phospholipase by Aeromonas salmonicida.
Journal of bacteriology 1989;171(5):2523-7.
1988: Garland W J; Buckley J T
The cytolytic toxin aerolysin must aggregate to disrupt erythrocytes, and aggregation is stimulated by human glycophorin.
Infection and immunity 1988;56(5):1249-53.
1988: Thornton J; Howard S P; Buckley J T
Molecular cloning of a phospholipid-cholesterol acyltransferase from Aeromonas hydrophila. Sequence homologies with lecithin-cholesterol acyltransferase and other lipases.
Biochimica et biophysica acta 1988;959(2):153-9.
1987: Howard S P; Garland W J; Green M J; Buckley J T
Nucleotide sequence of the gene for the hole-forming toxin aerolysin of Aeromonas hydrophila.
Journal of bacteriology 1987;169(6):2869-71.

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