FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

James Eric Gouaux

Research Profile

Concepts & Ideas

Procedures

X Ray Crystallography

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Ion Channel Gating

Phenomena

Co-author Network

Publications

TOP 3
Isabelle Baconguis; James Eric Gouaux
Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes.
Motoyuki Hattori; Ryan E Hibbs; James Eric Gouaux
A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening.
Motoyuki Hattori; James Eric Gouaux
Molecular mechanism of ATP binding and ion channel activation in P2X receptors.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of James Eric Gouaux (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Isabelle Baconguis; James Eric Gouaux
Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes.
Nature 2012;489(7416):400-5.
2012: Motoyuki Hattori; Ryan E Hibbs; James Eric Gouaux
A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening.
Structure (London, England : 1993) 2012;20(8):1293-9.
2012: Motoyuki Hattori; James Eric Gouaux
Molecular mechanism of ATP binding and ion channel activation in P2X receptors.
Nature 2012;485(7397):207-12.
2012: Harini Krishnamurthy; James Eric Gouaux
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.
Nature 2012;481(7382):469-74.
2011: Ryan E Hibbs; James Eric Gouaux
Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature 2011;474(7349):54-60.
2010: Chayne L Piscitelli; Harini Krishnamurthy; James Eric Gouaux
Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.
Nature 2010;468(7327):1129-32.
2010: Arijit Banerjee; Ellina Mikhailova; Stephen Cheley; Li-Qun Gu; Michelle Montoya; Yasuo Nagaoka; James Eric Gouaux; Hagan Bayley
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8165-70.
2009: Alexander I Sobolevsky; Michael P Rosconi; James Eric Gouaux
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
Nature 2009;462(7274):745-56.
2009: Paul L Shaffer; April Goehring; Aruna Shankaranarayanan; James Eric Gouaux
Structure and mechanism of a Na+-independent amino acid transporter.
Science (New York, N.Y.) 2009;325(5943):1010-4.
2009: Eric B Gonzales; Toshimitsu Kawate; James Eric Gouaux
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.
Nature 2009;460(7255):599-604.
2009: Toshimitsu Kawate; Jennifer Carlisle Michel; William T Birdsong; James Eric Gouaux
Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.
Nature 2009;460(7255):592-8.
2009: Rongsheng Jin; Satinder K Singh; Shenyan Gu; Hiroyasu Furukawa; Alexander I Sobolevsky; Jie Zhou; Yan Jin; James Eric Gouaux
Crystal structure and association behaviour of the GluR2 amino-terminal domain.
The EMBO journal 2009;28(12):1812-23.
2009: Harini Krishnamurthy; Chayne L Piscitelli; James Eric Gouaux
Unlocking the molecular secrets of sodium-coupled transporters.
Nature 2009;459(7245):347-55.
2009: James Eric Gouaux
Review. The molecular logic of sodium-coupled neurotransmitter transporters.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1514):149-54.
2008: Satinder K Singh; Chayne L Piscitelli; Atsuko Yamashita; James Eric Gouaux
A competitive inhibitor traps LeuT in an open-to-out conformation.
Science (New York, N.Y.) 2008;322(5908):1655-61.
2008: James Eric Gouaux
Rotaglide facilitation of stent deployment.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2008;71(6):857; author reply 858.
2007: Jayasankar Jasti; Hiroyasu Furukawa; Eric B Gonzales; James Eric Gouaux
Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH.
Nature 2007;449(7160):316-23.
2007: Satinder K Singh; Atsuko Yamashita; James Eric Gouaux
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature 2007;448(7156):952-6.
2007: Olga Boudker; Renae M Ryan; Dinesh Yernool; Keiko Shimamoto; James Eric Gouaux
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature 2007;445(7126):387-93.
2006: Neali Armstrong; Jayasankar Jasti; Mads Beich-Frandsen; James Eric Gouaux
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.
Cell 2006;127(1):85-97.
2006: Toshimitsu Kawate; James Eric Gouaux
Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins.
Structure (London, England : 1993) 2006;14(4):673-81.
2005: James Eric Gouaux; Roderick MacKinnon
Principles of selective ion transport in channels and pumps.
Science (New York, N.Y.) 2005;310(5753):1461-5.
2005: Hiroyasu Furukawa; Satinder K Singh; Romina Mancusso; James Eric Gouaux
Subunit arrangement and function in NMDA receptors.
Nature 2005;438(7065):185-92.
2005: Rongsheng Jin; Suzanne Clark; Autumn M Weeks; Joshua T Dudman; James Eric Gouaux; Kathryn M Partin
Mechanism of positive allosteric modulators acting on AMPA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(39):9027-36.
2005: Atsuko Yamashita; Satinder K Singh; Toshimitsu Kawate; Yan Jin; James Eric Gouaux
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters.
Nature 2005;437(7056):215-23.
2005: Stephen H White; James Eric Gouaux
Membrane proteins--pumping along.
Current opinion in structural biology 2005;15(4):375-7.
2005: Rich Olson; James Eric Gouaux
Crystal structure of the Vibrio cholerae cytolysin (VCC) pro-toxin and its assembly into a heptameric transmembrane pore.
Journal of molecular biology 2005;350(5):997-1016.
2005: Atsushi Inanobe; Hiroyasu Furukawa; James Eric Gouaux
Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.
Neuron 2005;47(1):71-84.
2005: Antoine Robert; Neali Armstrong; James Eric Gouaux; James R Howe
AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(15):3752-62.
2004: Dinesh Yernool; Olga Boudker; Yan Jin; James Eric Gouaux
Structure of a glutamate transporter homologue from Pyrococcus horikoshii.
Nature 2004;431(7010):811-8.
2004: stefania galdiero; James Eric Gouaux
High resolution crystallographic studies of alpha-hemolysin-phospholipid complexes define heptamer-lipid head group interactions: implication for understanding protein-lipid interactions.
Protein science : a publication of the Protein Society 2004;13(6):1503-11.
2004: James Eric Gouaux
Structure and function of AMPA receptors.
The Journal of physiology 2004;554(Pt 2):249-53.
2003: Dinesh Yernool; Olga Boudker; Ewa Folta-Stogniew; James Eric Gouaux
Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus.
Biochemistry 2003;42(44):12981-8.
2003: William N Zagotta; Nelson B Olivier; Kevin D Black; Edgar C Young; Rich Olson; James Eric Gouaux
Structural basis for modulation and agonist specificity of HCN pacemaker channels.
Nature 2003;425(6954):200-5.
2003: Rongsheng Jin; Tue G Banke; Mark L Mayer; Stephen F Traynelis; James Eric Gouaux
Structural basis for partial agonist action at ionotropic glutamate receptors.
Nature neuroscience 2003;6(8):803-10.
2003: Hiroyasu Furukawa; James Eric Gouaux
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.
The EMBO journal 2003;22(12):2873-85.
2003: Rongsheng Jin; James Eric Gouaux
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
Biochemistry 2003;42(18):5201-13.
2003: Neali Armstrong; Mark Mayer; James Eric Gouaux
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5736-41.
2003: Toshimitsu Kawate; James Eric Gouaux
Arresting and releasing Staphylococcal alpha-hemolysin at intermediate stages of pore formation by engineered disulfide bonds.
Protein science : a publication of the Protein Society 2003;12(5):997-1006.
2003: Marie-Louise Lunn; Anders Hogner; Tine B Stensbøl; James Eric Gouaux; Jan Egebjerg; Jette S Kastrup
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity.
Journal of medicinal chemistry 2003;46(5):872-5.
2003: Rich Olson; James Eric Gouaux
Vibrio cholerae cytolysin is composed of an alpha-hemolysin-like core.
Protein science : a publication of the Protein Society 2003;12(2):379-83.
2003: Anders Hogner; Jeremy R Greenwood; Tommy Liljefors; Marie-Louise Lunn; Jan Egebjerg; Ingrid K Larsen; James Eric Gouaux; Jette S Kastrup
Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.
Journal of medicinal chemistry 2003;46(2):214-21.
2003: Michelle Montoya; James Eric Gouaux
Beta-barrel membrane protein folding and structure viewed through the lens of alpha-hemolysin.
Biochimica et biophysica acta 2003;1609(1):19-27.
2002: Rongsheng Jin; Michelle Horning; Mark L Mayer; James Eric Gouaux
Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate.
Biochemistry 2002;41(52):15635-43.
2002: Christina Kasper; Marie-Louise Lunn; Tommy Liljefors; James Eric Gouaux; Jan Egebjerg; Jette S Kastrup
GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists.
FEBS letters 2002;531(2):173-8.
2002: Anders Hogner; Jette S Kastrup; R Jin; Tommy Liljefors; Mark L Mayer; Jan Egebjerg; Ingrid K Larsen; James Eric Gouaux
Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.
Journal of molecular biology 2002;322(1):93-109.
2002: Lei Zeng; Luying Lu; Michaela Muller; James Eric Gouaux; Ming-Ming Zhou
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors.
Journal of molecular neuroscience : MN 2002;19(1-2):113-6.
2002: Yu Sun; Rich Olson; Michelle Horning; Neali Armstrong; Mark Mayer; James Eric Gouaux
Mechanism of glutamate receptor desensitization.
Nature 2002;417(6886):245-53.
2002: Qing Cheng; Shalita Thiran; Dinesh Yernool; James Eric Gouaux; Vasanthi Jayaraman
A vibrational spectroscopic investigation of interactions of agonists with GluR0, a prokaryotic glutamate receptor.
Biochemistry 2002;41(5):1602-8.
2001: Mark L Mayer; Rich Olson; James Eric Gouaux
Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state.
Journal of molecular biology 2001;311(4):815-36.
2001: James Eric Gouaux; S H White
Lipids lost, lipids regained.
Current opinion in structural biology 2001;11(4):393-6.
2000: Neali Armstrong; James Eric Gouaux
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron 2000;28(1):165-81.
1999: G Q Chen; Changhai Cui; Mark L Mayer; James Eric Gouaux
Functional characterization of a potassium-selective prokaryotic glutamate receptor.
Nature 1999;402(6763):817-21.
1999: G Q Chen; James Eric Gouaux
Probing the folding and unfolding of wild-type and mutant forms of bacteriorhodopsin in micellar solutions: evaluation of reversible unfolding conditions.
Biochemistry 1999;38(46):15380-7.
1999: W Kühlbrandt; James Eric Gouaux
Membrane proteins.
Current opinion in structural biology 1999;9(4):445-7.
1999: Neali Armstrong; Alexandre de Lencastre; James Eric Gouaux
A new protein folding screen: application to the ligand binding domains of a glutamate and kainate receptor and to lysozyme and carbonic anhydrase.
Protein science : a publication of the Protein Society 1999;8(7):1475-83.
1999: Rich Olson; H Nariya; K Yokota; Y Kamio; James Eric Gouaux
Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel.
Nature structural biology 1999;6(2):134-40.
1998: G Q Chen; Y Sun; R Jin; James Eric Gouaux
Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct.
Protein science : a publication of the Protein Society 1998;7(12):2623-30.
1998: James Eric Gouaux
Roll out the barrel.
Nature structural biology 1998;5(11):931-2.
1998: Neali Armstrong; Yu Sun; G Q Chen; James Eric Gouaux
Structure of a glutamate-receptor ligand-binding core in complex with kainate.
Nature 1998;395(6705):913-7.
1998: James Eric Gouaux
Single potassium ion seeks open channel for transmembrane travels: tales from the KcsA structure.
Structure (London, England : 1993) 1998;6(10):1221-6.
1998: L Song; James Eric Gouaux
Crystallization of the alpha-hemolysin heptamer solubilized in decyldimethyl- and decyldiethylphosphine oxide.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 2):276-8.
1998: James Eric Gouaux
It's not just a phase: crystallization and X-ray structure determination of bacteriorhodopsin in lipidic cubic phases.
Structure (London, England : 1993) 1998;6(1):5-10.
1998: James Eric Gouaux
alpha-Hemolysin from Staphylococcus aureus: an archetype of beta-barrel, channel-forming toxins.
Journal of structural biology 1998;121(2):110-22.
1997: G Q Chen; James Eric Gouaux
Overexpression of a glutamate receptor (GluR2) ligand binding domain in Escherichia coli: application of a novel protein folding screen.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13431-6.
1997: Stephen Cheley; M S Malghani; L Song; M Hobaugh; James Eric Gouaux; J Yang; Hagan Bayley
Spontaneous oligomerization of a staphylococcal alpha-hemolysin conformationally constrained by removal of residues that form the transmembrane beta-barrel.
Protein engineering 1997;10(12):1433-43.
1997: James Eric Gouaux; M Hobaugh; L Song
alpha-Hemolysin, gamma-hemolysin, and leukocidin from Staphylococcus aureus: distant in sequence but similar in structure.
Protein science : a publication of the Protein Society 1997;6(12):2631-5.
1997: G Q Chen; James Eric Gouaux
Reduction of membrane protein hydrophobicity by site-directed mutagenesis: introduction of multiple polar residues in helix D of bacteriorhodopsin.
Protein engineering 1997;10(9):1061-6.
1997: James Eric Gouaux
Channel-forming toxins: tales of transformation.
Current opinion in structural biology 1997;7(4):566-73.
1997: Orit Braha; B Walker; Stephen Cheley; John Kasianowicz; L Song; James Eric Gouaux; Hagan Bayley
Designed protein pores as components for biosensors.
Chemistry & biology 1997;4(7):497-505.
1997: James Eric Gouaux
The long and short of colicin action: the molecular basis for the biological activity of channel-forming colicins.
Structure (London, England : 1993) 1997;5(3):313-7.
1996: L Song; M R Hobaugh; C Shustak; Stephen Cheley; Hagan Bayley; James Eric Gouaux
Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore.
Science (New York, N.Y.) 1996;274(5294):1859-66.
1996: G Q Chen; James Eric Gouaux
Overexpression of bacterio-opsin in Escherichia coli as a water-soluble fusion to maltose binding protein: efficient regeneration of the fusion protein and selective cleavage with trypsin.
Protein science : a publication of the Protein Society 1996;5(3):456-67.
1994: James Eric Gouaux; Orit Braha; M R Hobaugh; L Song; Stephen Cheley; C Shustak; Hagan Bayley
Subunit stoichiometry of staphylococcal alpha-hemolysin in crystals and on membranes: a heptameric transmembrane pore.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12828-31.
1993: R P Kosman; James Eric Gouaux; William N Lipscomb
Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins 1993;15(2):147-76.
1990: James Eric Gouaux; R C Stevens; William N Lipscomb
Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry 1990;29(33):7702-15.
1990: R C Stevens; James Eric Gouaux; William N Lipscomb
Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry 1990;29(33):7691-701.
1990: James Eric Gouaux; William N Lipscomb
Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry 1990;29(2):389-402.
1989: James Eric Gouaux; R C Stevens; Hengming Ke; William N Lipscomb
Crystal structure of the Glu-239----Gln mutant of aspartate carbamoyltransferase at 3.1-A resolution: an intermediate quaternary structure.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8212-6.
1989: James Eric Gouaux; William N Lipscomb; S A Middleton; Evan R Kantrowitz
Structure of a single amino acid mutant of aspartate carbamoyltransferase at 2.5-A resolution: implications for the cooperative mechanism.
Biochemistry 1989;28(4):1798-803.
1989: James Eric Gouaux; William N Lipscomb
Structural transitions in crystals of native aspartate carbamoyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):845-8.
1988: James Eric Gouaux; William N Lipscomb
Three-dimensional structure of carbamoyl phosphate and succinate bound to aspartate carbamoyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4205-8.
1987: James Eric Gouaux; K L Krause; William N Lipscomb
The catalytic mechanism of Escherichia coli aspartate carbamoyltransferase: a molecular modelling study.
Biochemical and biophysical research communications 1987;142(3):893-7.