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Calum Sutherland

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Publications

TOP 3
Antonio J Ruiz-Alcaraz; Calum Sutherland; Christopher Lipina; Andrew D Morris; Michael J Murphy; John R Petrie; Daniel J Cuthbertson
Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase.
Ritchie Williamson; Alison McNeilly; Calum Sutherland
Insulin resistance in the brain: an old-age or new-age problem?
Kaixin Zhou; Calum Sutherland; Celine Bellenguez; Peter Donnelly; Grahame Hardie; Colin Palmer; Ewan Pearson
The role of ATM in response to metformin treatment and activation of AMPK.

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All Publications

2013: Antonio J Ruiz-Alcaraz; Calum Sutherland; Christopher Lipina; Andrew D Morris; Michael J Murphy; John R Petrie; Daniel J Cuthbertson
Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase.
PloS one 2013;8(2):e56928.
2012: Ritchie Williamson; Alison McNeilly; Calum Sutherland
Insulin resistance in the brain: an old-age or new-age problem?
Biochemical pharmacology 2012;84(6):737-45.
2012: Kaixin Zhou; Calum Sutherland; Celine Bellenguez; Peter Donnelly; Grahame Hardie; Colin Palmer; Ewan Pearson
The role of ATM in response to metformin treatment and activation of AMPK.
Nature genetics 2012;44(4):361-2.
2011: Lindsay Graham; Calum Sutherland
Models of dementia: an introductory overview.
Biochemical Society transactions 2011;39(4):851-6.
2011: R Williamson; Calum Sutherland
Neuronal membranes are key to the pathogenesis of Alzheimer's disease: the role of both raft and non-raft membrane domains.
Current Alzheimer research 2011;8(2):213-21.
2011: Alison D McNeilly; Ritchie Williamson; Calum Sutherland; David J K Balfour; Caroline A Stewart
High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task.
Behavioural brain research 2011;217(1):134-41.
2011: Ritchie Williamson; Lynn Bedford; David Howlett; David M A Mann; John Mayer; Bettina Platt; Florian Plattner; Calum Sutherland; Alessia Usardi; Lidy van Aalten; Adam R Cole
CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases.
Journal of Alzheimer's disease : JAD 2011;27(3):615-25.
2011: Calum Sutherland
What Are the bona fide GSK3 Substrates?
International journal of Alzheimer's disease 2011;2011():505607.
2010: Marc P M Soutar; Woo-Yang Kim; Ritchie Williamson; Mark Peggie; C James Hastie; Hilary McLauchlan; William D Snider; Phillip R Gordon-Weeks; Calum Sutherland
Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain.
Journal of neurochemistry 2010;115(4):974-83.
2010: Lisa Logie; Antonio J Ruiz-Alcaraz; Christopher J Schofield; Harinder S Hundal; Giora Z Feuerstein; Jeffrey D Brady; Daniel Crowther; Anna M Tommasi; Christal E Grierson; Bridget Shepherd; Andrew D Morris; Michael K Hansen; Ewan Pearson; Calum Sutherland
Generation, validation and humanisation of a novel insulin resistant cell model.
Biochemical pharmacology 2010;80(7):1042-9.
2010: Emma L Clayton; Nancy Sue; Karen J Smillie; Timothy O'Leary; Nicolai Bache; Giselle Cheung; Adam R Cole; David J A Wyllie; Calum Sutherland; Phillip J Robinson; Michael A Cousin
Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.
Nature neuroscience 2010;13(7):845-51.
2009: Yvonne L Woods; John R Petrie; Calum Sutherland
Dissecting insulin signaling pathways: individualised therapeutic targets for diagnosis and treatment of insulin resistant states.
Endocrine, metabolic & immune disorders drug targets 2009;9(2):187-98.
2009: M P M Soutar; P Thornhill; Adam R Cole; Calum Sutherland
Increased CRMP2 phosphorylation is observed in Alzheimer's disease; does this tell us anything about disease development?
Current Alzheimer research 2009;6(3):269-78.
2009: Aileen Sandilands; Calum Sutherland; Alan D Irvine; W H Irwin McLean
Filaggrin in the frontline: role in skin barrier function and disease.
Journal of cell science 2009;122(Pt 9):1285-94.
2009: Ke Ning; Lisa C Miller; Hilary A Laidlaw; Kenneth R Watterson; Jennifer Gallagher; Calum Sutherland; Michael L J Ashford
Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.
The Journal of biological chemistry 2009;284(14):9331-40.
2008: Adam R Cole; Marc P M Soutar; Makoto Rembutsu; Lidy van Aalten; C James Hastie; Hilary McLauchlan; Mark Peggie; Martin Balastik; Kun Ping Lu; Calum Sutherland
Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.
The Journal of biological chemistry 2008;283(26):18227-37.
2008: Jose R Bayascas; Stephan Wullschleger; Kei Sakamoto; Juan M García-Martínez; Carol Clacher; David Komander; Daan M F van Aalten; Krishna M Boini; Florian Lang; Christopher Lipina; Lisa Logie; Calum Sutherland; John A Chudek; Janna A van Diepen; Peter J Voshol; John M Lucocq; Dario R Alessi
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Molecular and cellular biology 2008;28(10):3258-72.
2008: Makoto Rembutsu; Marc P M Soutar; Lidy Van Aalten; Robert Gourlay; C James Hastie; Hilary McLauchlan; Nick A Morrice; Adam R Cole; Calum Sutherland
Novel procedure to investigate the effect of phosphorylation on protein complex formation in vitro and in cells.
Biochemistry 2008;47(7):2153-61.
2008: Christian Holscher; Lidy van Aalten; Calum Sutherland
Anaesthesia generates neuronal insulin resistance by inducing hypothermia.
BMC neuroscience 2008;9():100.
2007: Adam R Cole; Wendy Noble; Lidy van Aalten; Florian Plattner; Rena Meimaridou; Dale Hogan; Margaret Taylor; John LaFrancois; Frank J Gunn-Moore; Alexei Verkhratsky; Salvatore Oddo; Frank M LaFerla; peter giese; Kelly T Dineley; karen duff; Jill C Richardson; Shi Du Yan; Diane P Hanger; Stuart M Allan; Calum Sutherland
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.
Journal of neurochemistry 2007;103(3):1132-44.
2007: Lisa Logie; Antonio J Ruiz-Alcaraz; Michael Keane; Yvonne L Woods; Jenny Bain; Rodolfo Marquez; Dario R Alessi; Calum Sutherland
Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells.
Diabetes 2007;56(9):2218-27.
2007: Daniel J Cuthbertson; John A Babraj; Kirsty J Mustard; Mhairi C Towler; Kevin A Green; Henning Wackerhage; Graham P Leese; Keith Baar; Michaela Thomason-Hughes; Calum Sutherland; D Grahame Hardie; Michael John Rennie
5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.
Diabetes 2007;56(8):2078-84.
2007: Thomas M Wishart; Janet M Paterson; Duncan M Short; Sara Meredith; Kevin A Robertson; Calum Sutherland; Michael A Cousin; Mayank B Dutia; Thomas H Gillingwater
Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene.
Molecular & cellular proteomics : MCP 2007;6(8):1318-30.
2007: Adam R Cole; Arlene Astell; Charlotte Green; Calum Sutherland
Molecular connexions between dementia and diabetes.
Neuroscience and biobehavioral reviews 2007;31(7):1046-63.
2006: David Finlay; Antonio J Ruiz-Alcaraz; Christopher Lipina; Stephane Perrier; Calum Sutherland
A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression.
Journal of molecular endocrinology 2006;37(2):227-37.
2006: Adam R Cole; frederic causeret; Gokhan Yadirgi; C James Hastie; Hilary McLauchlan; Edward J McManus; Félix Hernández; Britta J Eickholt; Margareta Nikolic; Calum Sutherland
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.
The Journal of biological chemistry 2006;281(24):16591-8.
2006: Liu Hui-Kang; Stephane Perrier; Christopher Lipina; David Finlay; Hilary McLauchlan; C James Hastie; Harinder S Hundal; Calum Sutherland
Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226.
BMC molecular biology 2006;7():14.
2005: Christopher Lipina; Xu Huang; David Finlay; Edward J McManus; Dario R Alessi; Calum Sutherland
Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.
The Biochemical journal 2005;392(Pt 3):633-9.
2005: Antonio J Ruiz-Alcaraz; Liu Hui-Kang; Daniel J Cuthbertson; Edward J McManus; Simeen Akhtar; Christopher Lipina; Andrew D Morris; John R Petrie; Harinder S Hundal; Calum Sutherland
A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.
The Biochemical journal 2005;392(Pt 2):345-52.
2005: Katrina MacAulay; Anne Blair; Eric Hajduch; Tatsuo Terashima; Otto Baba; Calum Sutherland; Harinder S Hundal
Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells.
The Journal of biological chemistry 2005;280(10):9509-18.
2005: Franck Rencurel; Alasdair Stenhouse; Simon A Hawley; Thomas Friedberg; D Grahame Hardie; Calum Sutherland; C Roland Wolf
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.
The Journal of biological chemistry 2005;280(6):4367-73.
2005: Alfonso Mora; Christopher Lipina; François Tronche; Calum Sutherland; Dario R Alessi
Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.
The Biochemical journal 2005;385(Pt 3):639-48.
2004: Shirin Mirshamsi; Hilary A Laidlaw; Ke Ning; Erin Anderson; Laura A Burgess; Alex Gray; Calum Sutherland; Michael L J Ashford
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation.
BMC neuroscience 2004;5():54.
2004: Adam R Cole; Axel Knebel; Nick A Morrice; Laura A Robertson; Andrew J Irving; Christopher N Connolly; Calum Sutherland
GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.
The Journal of biological chemistry 2004;279(48):50176-80.
2004: David Finlay; Satish Patel; Lorna M Dickson; Natalia Shpiro; Rodolfo Marquez; Chris J Rhodes; Calum Sutherland
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
BMC molecular biology 2004;5():15.
2004: Rolf Grempler; Anne Kienitz; Torsten Werner; Marion Meyer; Andreas Barthel; Fabienne Ailett; Calum Sutherland; Reinhard Walther; Dieter Schmoll
Tumour necrosis factor alpha decreases glucose-6-phosphatase gene expression by activation of nuclear factor kappaB.
The Biochemical journal 2004;382(Pt 2):471-9.
2004: Jackie M Kinsella; Hilary A Laidlaw; Teresa Tang; Jenni Harvey; Calum Sutherland; Michael L J Ashford
The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1.
BMC pharmacology 2004;4():17.
2003: Satish Patel; Christopher Lipina; Calum Sutherland
Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element.
FEBS letters 2003;549(1-3):72-6.
2002: Satish Patel; Jeroen van der Kaay; Calum Sutherland
Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide.
The Biochemical journal 2002;365(Pt 2):537-45.
2002: Satish Patel; Pamela A Lochhead; Graham Rena; Stefano Fumagalli; Mario Pende; Sara C Kozma; George Thomas; Calum Sutherland
Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity.
The Journal of biological chemistry 2002;277(12):9889-95.
2001: Satish Patel; Pamela A Lochhead; Graham Rena; Calum Sutherland
Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression.
The Biochemical journal 2001;359(Pt 3):611-9.
2001: Pamela A Lochhead; M Coghlan; S Q Rice; Calum Sutherland
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.
Diabetes 2001;50(5):937-46.
2000: Mary Waltner-Law; M C Daniels; Calum Sutherland; Daryl K Granner
NF-kappa B inhibits glucocorticoid and cAMP-mediated expression of the phosphoenolpyruvate carboxykinase gene.
The Journal of biological chemistry 2000;275(41):31847-56.
2000: Pamela A Lochhead; IP Salt; KS Walker; D Grahame Hardie; Calum Sutherland
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
Diabetes 2000;49(6):896-903.
2000: JC Wang; John M Stafford; Donald Scott; Calum Sutherland; Daryl K Granner
The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis.
The Journal of biological chemistry 2000;275(19):14717-21.
1999: K Kotani; Wataru Ogawa; Y Hino; T Kitamura; H Ueno; W Sano; Calum Sutherland; D K Granner; Masato Kasuga
Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription.
The Journal of biological chemistry 1999;274(30):21305-12.
1998: Calum Sutherland; Mary Waltner-Law; Luigi Gnudi; Barbara B Kahn; Daryl K Granner
Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin.
The Journal of biological chemistry 1998;273(6):3198-204.
1997: Calum Sutherland; P W Tebbey; Daryl K Granner
Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate carboxykinase in hepatoma cells.
Diabetes 1997;46(1):17-22.
1996: H Osawa; Calum Sutherland; R B Robey; Richard L Printz; Daryl K Granner
Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin.
The Journal of biological chemistry 1996;271(28):16690-4.
1996: Calum Sutherland; Richard M O'Brien; Daryl K Granner
New connections in the regulation of PEPCK gene expression by insulin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):191-9.
1996: R A Gabbay; Calum Sutherland; Luigi Gnudi; Barbara B Kahn; R M O'Brien; Daryl K Granner; Jeffrey S Flier
Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway.
The Journal of biological chemistry 1996;271(4):1890-7.
1995: Calum Sutherland; Richard M O'Brien; Daryl K Granner
Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression.
The Journal of biological chemistry 1995;270(26):15501-6.
1994: Calum Sutherland; Philip Cohen
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.
FEBS letters 1994;338(1):37-42.
1993: Calum Sutherland; I A Leighton; Philip Cohen
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
The Biochemical journal 1993;296 ( Pt 1)():15-9.
1993: Calum Sutherland; J Alterio; D G Campbell; B Le Bourdellès; Jacques Mallet; J Haavik; Philip Cohen
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.
European journal of biochemistry / FEBS 1993;217(2):715-22.
1992: Philip Cohen; D G Campbell; P Dent; N Gomez; A Lavoinne; S Nakielny; David Stokoe; Calum Sutherland; S Traverse
Dissection of the protein kinase cascades involved in insulin and nerve growth factor action.
Biochemical Society transactions 1992;20(3):671-4.
1989: R J Williams; A D McCarthy; Calum Sutherland
Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat.
Biochimica et biophysica acta 1989;1003(2):213-6.