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Friedrich Grimminger

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Pulmonary Circulation

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Djuro Kosanovic; Irwin Reiss; Ralph Theo Schermuly; Werner Seeger; Norbert Weissmann; Malgorzata Wygrecka; Bhola Kumar Dahal; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Andreas Günther; Gamal-Andre Banat
Mast cell Chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
Marius M Hoeper; David Lawrence; Nicholas W Morrell; Andrew J Peacock; Deborah A Quinn; Toru Satoh; Gérald Simonneau; Victor F Tapson; Fernando Torres; Robyn J Barst; Robert C Bourge; Jeremy Feldman; Adaani E Frost; Nazzareno Galié; Miguel Angel Gómez-Sánchez; Friedrich Grimminger; Ekkehard Grünig; Paul M Hassoun; Hossein-Ardeschir Ghofrani
Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study.
Soni Pullamsetti; Gamal-Andre Banat; T Braun; Friedrich Grimminger; Jörg Hänze; E Kolosionek; D Pomagruk; Ralph Theo Schermuly; A Schmall; Werner Seeger; M Szibor; Jochen Wilhelm; Rajkumar Savai
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.

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All Publications

2013: Djuro Kosanovic; Irwin Reiss; Ralph Theo Schermuly; Werner Seeger; Norbert Weissmann; Malgorzata Wygrecka; Bhola Kumar Dahal; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Andreas Günther; Gamal-Andre Banat
Mast cell Chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
Histology and histopathology 2013;28(6):691-9.
2013: Marius M Hoeper; David Lawrence; Nicholas W Morrell; Andrew J Peacock; Deborah A Quinn; Toru Satoh; Gérald Simonneau; Victor F Tapson; Fernando Torres; Robyn J Barst; Robert C Bourge; Jeremy Feldman; Adaani E Frost; Nazzareno Galié; Miguel Angel Gómez-Sánchez; Friedrich Grimminger; Ekkehard Grünig; Paul M Hassoun; Hossein-Ardeschir Ghofrani
Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study.
Circulation 2013;127(10):1128-38.
2013: Soni Pullamsetti; Gamal-Andre Banat; T Braun; Friedrich Grimminger; Jörg Hänze; E Kolosionek; D Pomagruk; Ralph Theo Schermuly; A Schmall; Werner Seeger; M Szibor; Jochen Wilhelm; Rajkumar Savai
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.
Oncogene 2013;32(9):1121-34.
2013: Katja Hattar; Dagmar S Lang; Rajkumar Savai; Ralph Theo Schermuly; Anja Schmall; Werner Seeger; Ulf Sibelius; Florentine S B Subtil; Ekkehard Vollmer; Jochen Wilhelm; Gamal-Andre Banat; Gabriele Dahlem; Bastian Eul; Ludger Fink; Torsten Goldmann; Friedrich Grimminger; Ulrich Grandel
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.
Cancer immunology, immunotherapy : CII 2013;62(2):309-20.
2013: Christine Veith; Florian Veit; Norbert Weissmann; Jochen Wilhelm; Bhola Kumar Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Gabriel Marta; Ralph Theo Schermuly; Sigrid Schmitt; Werner Seeger; Grazyna Kwapiszewska
Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension.
Proteomics 2013;13(1):75-88.
2012: Rajkumar Savai; Axel Scheed; Werner Seeger; Axel Vater; Robert Voswinckel; Norbert Weissmann; Gamal-Andre Banat; Ewa Bieniek; Bhola K Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Sven Klussmann; Julia Kolbe; Soni Pullamsetti; Christin Ritter; Ralph Theo Schermuly
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2012;186(9):897-908.
2012: Norbert Weissmann; Friedrich Grimminger; Werner Seeger
Smoking: Is it a risk factor for pulmonary vascular diseases?
Pulmonary circulation 2012;2(4):395-6.
2012: Soni Pullamsetti; Stephan Rosenkranz; Rajkumar Savai; Werner Seeger; Aleksandra Tretyn; Norbert Weissmann; Eva Maria Berghausen; Ralf P Brandes; Elsa Butrous; Ghazwan Butrous; Swati Dabral; Bhola Kumar Dahal; Hossein A Ghofrani; Friedrich Grimminger; Ralph Theo Schermuly
Role of Src tyrosine kinases in experimental pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(6):1354-65.
2012: Manish Mittal; Oleg Pak; Matthew E Pamenter; Ralph Theo Schermuly; Werner Seeger; Ralf P Brandes; D Beate Fuchs; H A Ghofrani; Friedrich Grimminger; Xiang Q Gu; Daniela Haag; Gabriel G Haddad; Norbert Weissmann
Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species.
Free radical biology & medicine 2012;52(6):1033-42.
2012: Andrea Mietens; Friedrich Grimminger; Gerrit Eichner; Johanna Volkmann; Sabine Tasch; Ralph Theo Schermuly; Caroline Feuerstacke; Dieter Müller; Ralf Middendorff
Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not.
Molecular and cellular endocrinology 2012;349(2):145-53.
2012: Soni Pullamsetti; Rajkumar Savai; Werner Seeger; Norbert Weissmann; Andreas M Zeiher; Angelika Bonauer; Bhola K Dahal; Stefanie Dimmeler; Carmen Doebele; Ariane Fischer; Hossein A Ghofrani; Friedrich Grimminger; Baktybek Kojonazarov; Ralph Theo Schermuly
Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2012;185(4):409-19.
2012: Michaela Lang; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Anuar Kalymbetov; Baktybek Kojonazarov; Axel Kretschmer; Werner Seeger; Johannes-Peter Stasch; Xia Tian; Norbert Weissmann; Ralph Theo Schermuly
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.
PloS one 2012;7(8):e43433.
2012: Norbert Weissmann; Michael Mederos y Schnitzler; Ralf P Brandes; Alison C Brewer; Marc Freichel; Beate Fuchs; Hossein A Ghofrani; Friedrich Grimminger; Thomas Gudermann; Hermann Kalwa; Karl-Heinz Krause; Marcel Meissner; Stefan Offermanns; Oleg Pak; Ralph Theo Schermuly; Harald H H W Schmidt; Werner Seeger; Ajay M Shah; Ursula Storch; Akylbek Sydykov; Florian Veit; Alexander Dietrich
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
Nature communications 2012;3():649.
2012: Farzaneh Ketabchi; Ralph T Schermuly; Werner Seeger; S Mostafa Shid-Moosavi; Gholam A Dehghani; Bakytbek Egemnazarov; Hossein A Ghofrani; Friedrich Grimminger; Norbert Weissmann; Natascha Sommer
Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction.
Respiratory research 2012;13():7.
2011: Michael Seimetz; Akylbek Sydykov; Agnieszka Turowska; Florian Veit; Robert Voswinckel; Friederike C Weisel; Rio Dumitrascu; Bakytbek Egemnazarov; Beate Fuchs; Holger Garn; Hossein A Ghofrani; Friedrich Grimminger; Peter Jaksch; Walter Klepetko; Sawa Kostin; Grazyna Kwapiszewska; Thomas Medebach; Katrin Milger; Sandeep Nikam; Nirmal Parajuli; Alexandra Pichl; Markus Roth; Ralph T Schermuly; Werner Seeger; Norbert Weissmann
Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice.
Cell 2011;147(2):293-305.
2011: Ralph T Schermuly; Martin R Wilkins; Hossein A Ghofrani; Friedrich Grimminger
Mechanisms of disease: pulmonary arterial hypertension.
Nature reviews. Cardiology 2011;8(8):443-55.
2011: Soni Pullamsetti; Rajkumar Savai; Werner Seeger; Norbert Weissmann; Jochen Wilhelm; Dariusz Zakrzewicz; Bhola Kumar Dahal; Rio Dumitrascu; Oliver Eickelberg; Hossein A Ghofrani; Friedrich Grimminger; Andreas Guenther; Melanie Konigshoff; James Leiper; Ralph Theo Schermuly
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Science translational medicine 2011;3(87):87ra53.
2011: R Dumitrascu; C Kulcke; M Königshoff; F Kouri; X Yang; N Morrell; Hossein A Ghofrani; Norbert Weissmann; R Reiter; Werner Seeger; Friedrich Grimminger; O Eickelberg; Ralph Theo Schermuly; S S Pullamsetti
Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;37(5):1104-18.
2011: Bhola K Dahal; Hossein A Ghofrani; Friedrich Grimminger; Rainer Heuchel; Soni Pullamsetti; Werner Seeger; Norbert Weissmann; Jochen Wilhelm; Ralph Theo Schermuly
Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.
Pulmonary circulation 2011;1(2):259-68.
2011: Melanie Thamm; Henning Tiede; Robert Voswinckel; Friedrich Grimminger; Friederike Lendeckel; Werner Seeger; Hossein A Ghofrani
Air travel can be safe and well tolerated in patients with clinically stable pulmonary hypertension.
Pulmonary circulation 2011;1(2):239-43.
2011: Ralph T Schermuly; Wiebke Janssen; Norbert Weissmann; Johannes-Peter Stasch; Friedrich Grimminger; Hossein Ardeschir Ghofrani
Riociguat for the treatment of pulmonary hypertension.
Expert opinion on investigational drugs 2011;20(4):567-76.
2011: Soni Savai Pullamsetti; Rajkumar Savai; Martina Barbara Schaefer; Jochen Wilhelm; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; Ingrid Fleming; Konstantin Mayer; James Leiper; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Circulation 2011;123(11):1194-204.
2011: Djuro Kosanovic; Himal Luitel; Werner Seeger; Akylbek Sydykov; Norbert Weissmann; Ralf P Brandes; Teodora Cornitescu; Bhola K Dahal; Neil Davie; Hossein A Ghofrani; Friedrich Grimminger; Wiebke Janssen; Baktybek Kojonazarov; Ralph Theo Schermuly
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Respiratory research 2011;12():87.
2011: Bhola K Dahal; Djuro Kosanovic; Christina Kaulen; Teodora Cornitescu; Rajkumar Savai; Julia Hoffmann; Irwin Reiss; Hossein A Ghofrani; Norbert Weissmann; Wolfgang M Kuebler; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.
Respiratory research 2011;12():60.
2011: Piotr Sklepkiewicz; Ralph Theo Schermuly; Xia Tian; Hossein Ardeschir Ghofrani; Norbert Weissmann; Daniel Sedding; Tarek Kashour; Werner Seeger; Friedrich Grimminger; Soni Savai Pullamsetti
Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.
PloS one 2011;6(4):e18883.
2011: Xia Tian; Christina Vroom; Hossein Ardeschir Ghofrani; Norbert Weissmann; Ewa Bieniek; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly; Soni Savai Pullamsetti
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.
PloS one 2011;6(4):e18136.
2011: Beate Fuchs; Markus Rupp; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Thomas Gudermann; Alexander Dietrich; Norbert Weissmann
Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.
Respiratory research 2011;12():20.
2011: Paul A Nguewa; Alfonso Calvo; Soni Savai Pullamsetti; Gamal-Andre Banat; Friedrich Grimminger; Rajkumar Savai
Tyrosine kinase inhibitors with antiangiogenic properties for the treatment of non-small cell lung cancer.
Expert opinion on investigational drugs 2011;20(1):61-74.
2011: S S Pullamsetti; Rajkumar Savai; W Janssen; B K Dahal; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani; Norbert Weissmann; Ralph Theo Schermuly
Inflammation, immunological reaction and role of infection in pulmonary hypertension.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2011;17(1):7-14.
2010: Beate Fuchs; Natascha Sommer; Alexander Dietrich; Ralph Theo Schermuly; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Werner Seeger; Thomas Gudermann; Norbert Weissmann
Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction.
Respiratory physiology & neurobiology 2010;174(3):282-91.
2010: Friedrich Grimminger; Ralph T Schermuly; Hossein A Ghofrani
Targeting non-malignant disorders with tyrosine kinase inhibitors.
Nature reviews. Drug discovery 2010;9(12):956-70.
2010: Melanie Königshoff; Rio Dumitrascu; Sergey Udalov; Oana Veronica Amarie; Rudolf Reiter; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly; Oliver Eickelberg
Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention.
Thorax 2010;65(11):949-55.
2010: Hossein A Ghofrani; Nicholas W Morrell; Marius M Hoeper; Horst Olschewski; Andrew J Peacock; Robyn J Barst; Shelley Shapiro; Heiko Golpon; Mark Toshner; Friedrich Grimminger; Steve Pascoe
Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy.
American journal of respiratory and critical care medicine 2010;182(9):1171-7.
2010: N Sommer; O Pak; S Schörner; T Derfuss; A Krug; E Gnaiger; Hossein A Ghofrani; Ralph Theo Schermuly; C Huckstorf; Werner Seeger; Friedrich Grimminger; Norbert Weissmann
Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(5):1056-66.
2010: Ladislau Kiss; Hartwig Schütte; Winfried Padberg; Norbert Weissmann; Konstantin Mayer; Tobias Gessler; Robert Voswinckel; Werner Seeger; Friedrich Grimminger
Epoxyeicosatrienoates are the dominant eicosanoids in human lungs upon microbial challenge.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(5):1088-98.
2010: B K Dahal; D Kosanovic; P K Pamarthi; A Sydykov; Y-J Lai; R Kast; H Schirok; J-P Stasch; Hossein A Ghofrani; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(4):808-18.
2010: Hossein A Ghofrani; Marius M Hoeper; M Halank; F J Meyer; G Staehler; Jürgen Behr; R Ewert; G Weimann; Friedrich Grimminger
Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(4):792-9.
2010: Jun Yang; Xiaohui Li; Rafia S Al-Lamki; Mark Southwood; Jing Zhao; Andrew M Lever; Friedrich Grimminger; Ralph T Schermuly; Nicholas W Morrell
Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.
Circulation research 2010;107(2):252-62.
2010: Katja Hattar; S Oppermann; C Ankele; Norbert Weissmann; Ralph Theo Schermuly; Rainer M Bohle; R Moritz; B Krögel; Werner Seeger; Friedrich Grimminger; Ulf Sibelius; Ulrich Grandel
c-ANCA-induced neutrophil-mediated lung injury: a model of acute Wegener's granulomatosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(1):187-95.
2010: Heinrike Wilkens; Friedrich Grimminger; M Hoeper; G Stähler; B Ehlken; C Plesnila-Frank; K Berger; A Resch; A Ghofrani
Burden of pulmonary arterial hypertension in Germany.
Respiratory medicine 2010;104(6):902-10.
2010: Holger M Nef; Helge Möllmann; Christian Hamm; Friedrich Grimminger; Hossein-Ardeschir Ghofrani
Pulmonary hypertension: updated classification and management of pulmonary hypertension.
Heart (British Cardiac Society) 2010;96(7):552-9.
2010: Hossein-Ardeschir Ghofrani; Robert Voswinckel; Henning Gall; Ralph Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Riociguat for pulmonary hypertension.
Future cardiology 2010;6(2):155-66.
2010: Bhola Kumar Dahal; Teodora Cornitescu; Aleksandra Tretyn; Soni Savai Pullamsetti; Djuro Kosanovic; Rio Dumitrascu; Hossein A Ghofrani; Norbert Weissmann; Robert Voswinckel; Gamal-Andre Banat; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2010;181(2):158-67.
2010: Sevdalina Nikolova; Andreas Guenther; Rajkumar Savai; Norbert Weissmann; Hossein A Ghofrani; Melanie Konigshoff; Oliver Eickelberg; Walter Klepetko; Robert Voswinckel; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly; Soni Pullamsetti
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.
Respiratory research 2010;11():146.
2010: Bakytbek Egemnazarov; Ralph Theo Schermuly; Bhola K Dahal; Garry T Elliott; Niel C Hoglen; Mark W Surber; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction.
Respiratory research 2010;11():81.
2010: Sergey Udalov; Rio Dumitrascu; Soni Pullamsetti; Hamza M Al-tamari; Norbert Weissmann; Hossein A Ghofrani; Andreas Guenther; Robert Voswinckel; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.
BMC pulmonary medicine 2010;10():26.
2010: Friedrich Grimminger; Ralph Theo Schermuly
PDGF receptor and its antagonists: role in treatment of PAH.
Advances in experimental medicine and biology 2010;661():435-46.
2010: Beate Fuchs; Alexander Dietrich; Thomas Gudermann; Hermann Kalwa; Friedrich Grimminger; Norbert Weissmann
The role of classical transient receptor potential channels in the regulation of hypoxic pulmonary vasoconstriction.
Advances in experimental medicine and biology 2010;661():187-200.
2010: Rajkumar Savai; Soni Savai Pullamsetti; Gamal-Andre Banat; Norbert Weissmann; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Ralph Theo Schermuly
Targeting cancer with phosphodiesterase inhibitors.
Expert opinion on investigational drugs 2010;19(1):117-31.
2009: Ewa Kolosionek; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Andreas Guenther; Friedrich Grimminger; Werner Seeger; Gamal-Andre Banat; Ralph Theo Schermuly; Soni Pullamsetti
Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.
Molecular biology of the cell 2009;20(22):4751-65.
2009: Farzaneh Ketabchi; Bakytbek Egemnazarov; Ralph T Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Mostafa Shid-Moosavi; Gholam A Dehghani; Norbert Weissmann; Natascha Sommer
Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction.
American journal of physiology. Lung cellular and molecular physiology 2009;297(5):L977-83.
2009: Ulrich Grandel; Diana Heygster; Ulf Sibelius; Ludger Fink; Stefanie Sigel; Werner Seeger; Friedrich Grimminger; Katja Hattar
Amplification of lipopolysaccharide-induced cytokine synthesis in non-small cell lung cancer/neutrophil cocultures.
Molecular cancer research : MCR 2009;7(10):1729-35.
2009: Norbert Weissmann; Sascha Hackemack; Bhola Kumar Dahal; Soni Savai Pullamsetti; Rajkumar Savai; Manish Mittal; Beate Fuchs; Thomas Medebach; Rio Dumitrascu; Martin van Eickels; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.
American journal of physiology. Lung cellular and molecular physiology 2009;297(4):L658-65.
2009: Lidija Cakarova; Leigh M Marsh; Jochen Wilhelm; Konstantin Mayer; Friedrich Grimminger; Werner Seeger; Jürgen Lohmeyer; Susanne Herold
Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.
American journal of respiratory and critical care medicine 2009;180(6):521-32.
2009: Robert Voswinckel; Frank Reichenberger; H Gall; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
[Therapy of pulmonary arterial hypertension].
Der Internist 2009;50(9):1101-2, 1104-9.
2009: Markus Roth; Markus Rupp; Simone Hofmann; Manish Mittal; Beate Fuchs; Natascha Sommer; Nirmal Parajuli; Karin Quanz; Dominic Schubert; Eva Dony; Ralph Theo Schermuly; Hossein A Ghofrani; Ulrike Sausbier; Katrin Rutschmann; Sarah Wilhelm; Werner Seeger; Peter Ruth; Friedrich Grimminger; Matthias Sausbier; Norbert Weissmann
Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.
American journal of respiratory and critical care medicine 2009;180(4):353-64.
2009: Philipp Markart; Hossein A Ghofrani; Friedrich Grimminger; A Günther
[Pulmonary hypertension in COPD and interstitial lung diseases].
Deutsche medizinische Wochenschrift (1946) 2009;134 Suppl 5():S164-6.
2009: D Dumitrescu; H A Ghofrani; Friedrich Grimminger; M M Hoeper; Stephan Rosenkranz
[Update: Current clinical developments in pulmonary hypertension].
Deutsche medizinische Wochenschrift (1946) 2009;134 Suppl 5():S160-3.
2009: W Janssen; H A Ghofrani; N Weissmann; Friedrich Grimminger; R T Schermuly
[Update: Preclinical developments for the treatment of pulmonary arterial hypertension].
Deutsche medizinische Wochenschrift (1946) 2009;134 Suppl 5():S157-9.
2009: Hossein A Ghofrani; Robyn J Barst; Raymond L Benza; Hunter C Champion; Karen A Fagan; Friedrich Grimminger; Marc Humbert; Gérald Simonneau; Duncan J Stewart; Carlo Ventura; Lewis J Rubin
Future perspectives for the treatment of pulmonary arterial hypertension.
Journal of the American College of Cardiology 2009;54(1 Suppl):S108-17.
2009: Paul M Hassoun; Luc Mouthon; Joan A Barberà; Saadia Eddahibi; Sonia C Flores; Friedrich Grimminger; Peter Lloyd Jones; Michael L Maitland; Evangelos D Michelakis; Nicholas W Morrell; John H Newman; Marlene Rabinovitch; Ralph Schermuly; Kurt R Stenmark; Norbert F Voelkel; Jason X-J Yuan; Marc Humbert
Inflammation, growth factors, and pulmonary vascular remodeling.
Journal of the American College of Cardiology 2009;54(1 Suppl):S10-9.
2009: Ulrich Grandel; Ulrich Bennemann; Michael Buerke; Katja Hattar; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Staphylococcus aureus alpha-toxin and Escherichia coli hemolysin impair cardiac regional perfusion and contractile function by activating myocardial eicosanoid metabolism in isolated rat hearts.
Critical care medicine 2009;37(6):2025-32.
2009: N J Davie; R T Schermuly; N Weissmann; Friedrich Grimminger; H A Ghofrani
The science of endothelin-1 and endothelin receptor antagonists in the management of pulmonary arterial hypertension: current understanding and future studies.
European journal of clinical investigation 2009;39 Suppl 2():38-49.
2009: Isabel P Laumanns; Ludger Fink; Jochen Wilhelm; Jens-C Wolff; Rita Mitnacht-Kraus; Sabine Graef-Hoechst; Maria M Stein; Rainer M Bohle; Walter Klepetko; Mir A R Hoda; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger; Robert Voswinckel
The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension.
American journal of respiratory cell and molecular biology 2009;40(6):683-91.
2009: Ying Yu; Steve H Keller; Carmelle V Remillard; Olga Safrina; Ann Nicholson; Shenyuan L Zhang; Weihua Jiang; Nivruthi Vangala; Judd W Landsberg; Jian-Ying Wang; Patricia A Thistlethwaite; Richard N Channick; Ivan M Robbins; James E Loyd; Hossein A Ghofrani; Friedrich Grimminger; Ralph T Schermuly; Michael D Cahalan; Lewis J Rubin; Jason X-J Yuan
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.
Circulation 2009;119(17):2313-22.
2009: Friedrich Grimminger; G Weimann; Reiner Frey; Robert Voswinckel; M Thamm; D Bölkow; Norbert Weissmann; W Mück; S Unger; G Wensing; Ralph Theo Schermuly; Hossein A Ghofrani
First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(4):785-92.
2009: K Woyda; S Koebrich; Irwin Reiss; Silvia Rudloff; Soni Pullamsetti; A Rühlmann; Norbert Weissmann; Hossein A Ghofrani; Andreas Günther; Werner Seeger; Friedrich Grimminger; Rory Morty; Ralph Theo Schermuly
Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(4):861-70.
2009: H A Ghofrani; Friedrich Grimminger
Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy.
European respiratory review : an official journal of the European Respiratory Society 2009;18(111):35-41.
2009: Bakytbek Egemnazarov; Akylbek Sydykov; Ralph Theo Schermuly; Norbert Weissmann; Johannes-Peter Stasch; Akpai S Sarybaev; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology 2009;296(3):L462-9.
2009: F Kamlah; Bastian Eul; S Li; N Lang; Leigh M Marsh; Werner Seeger; Friedrich Grimminger; Frank Rose; Jörg Hänze
Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model.
Cancer gene therapy 2009;16(3):195-205.
2009: Robert Voswinckel; Frank Reichenberger; Henning Gall; Thomas Schmehl; Tobias Gessler; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Werner Seeger; Hossein A Ghofrani; Horst Olschewski
Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2009;22(1):50-6.
2009: Rajkumar Savai; Alexander Claus Langheinrich; Ralph Theo Schermuly; Soni Savai Pullamsetti; Rio Dumitrascu; Horst Traupe; Wigbert Stephan Rau; Werner Seeger; Friedrich Grimminger; Gamal Andre Banat
Evaluation of angiogenesis using micro-computed tomography in a xenograft mouse model of lung cancer.
Neoplasia (New York, N.Y.) 2009;11(1):48-56.
2009: Hossein-Ardeschir Ghofrani; Friedrich Grimminger
Modulating cGMP to treat lung diseases.
Handbook of experimental pharmacology 2009;(191):469-83.
2008: N Sommer; Alexander Dietrich; Ralph Theo Schermuly; Hossein A Ghofrani; Thomas Gudermann; Rainer Schulz; Werner Seeger; Friedrich Grimminger; Norbert Weissmann
Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(6):1639-51.
2008: Martina Klein; Ralph Theo Schermuly; Peter Ellinghaus; Hendrik Milting; Bernd Riedl; Sevdalina Nikolova; Soni S Pullamsetti; Norbert Weissmann; Eva Dony; Rajkumar Savai; Hossein A Ghofrani; Friedrich Grimminger; Andreas E Busch; Stefan Schäfer
Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.
Circulation 2008;118(20):2081-90.
2008: Ghazwan Butrous; Hossein Ardeschir Ghofrani; Friedrich Grimminger
Pulmonary vascular disease in the developing world.
Circulation 2008;118(17):1758-66.
2008: Marius M Hoeper; Hossein A Ghofrani; Friedrich Grimminger; S Rosenkranz
[Dana Point: what is new in the treatment of pulmonary hypertension?].
Deutsche medizinische Wochenschrift (1946) 2008;133 Suppl 6():S191-5.
2008: R Schermuly; Friedrich Grimminger
[Update in basic research in the therapy of pulmonary arterial hypertension].
Deutsche medizinische Wochenschrift (1946) 2008;133 Suppl 6():S170-2.
2008: Ladislau Kiss; Jens Bier; Yasmin Röder; Norbert Weissmann; Friedrich Grimminger; Werner Seeger
Direct and simultaneous profiling of epoxyeicosatrienoic acid enantiomers by capillary tandem column chiral-phase liquid chromatography with dual online photodiode array and tandem mass spectrometric detection.
Analytical and bioanalytical chemistry 2008;392(4):717-26.
2008: Robert Voswinckel; Frank Reichenberger; Beate Enke; Andre Kreckel; Stefanie Krick; Henning Gall; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Horst Olschewski; Werner Seeger; Hossein A Ghofrani
Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2008;21(5):824-32.
2008: Shu Li; Sarvenaz Shafiei Tabar; Viktor Malec; Bastian G Eul; Walter Klepetko; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Frank Rose; Jörg Hänze
NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts.
Antioxidants & redox signaling 2008;10(10):1687-98.
2008: Ralph Theo Schermuly; J-P Stasch; Soni Pullamsetti; Ralf Middendorff; D Müller; Klaus-Dieter Schlüter; A Dingendorf; S Hackemack; E Kolosionek; C Kaulen; Rio Dumitrascu; Norbert Weissmann; J Mittendorf; Walter Klepetko; Werner Seeger; Hossein A Ghofrani; Friedrich Grimminger
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(4):881-91.
2008: Grazyna Kwapiszewska; Malgorzata Wygrecka; Leigh M Marsh; Sigrid Schmitt; Roger Trösser; Jochen Wilhelm; Katja Helmus; Bastian Eul; Anna Zakrzewicz; Hossein A Ghofrani; Ralph Theo Schermuly; Rainer M Bohle; Friedrich Grimminger; Werner Seeger; Oliver Eickelberg; Ludger Fink; Norbert Weissmann
Fhl-1, a new key protein in pulmonary hypertension.
Circulation 2008;118(11):1183-94.
2008: Katrin Ahlbrecht; Judith Schmitz; Ulrike Seay; Christine Schwarz; Rita Mittnacht-Kraus; Andreas Gaumann; Rainer V Haberberger; Susanne Herold; Georg Breier; Friedrich Grimminger; Werner Seeger; Robert Voswinckel
Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development.
American journal of respiratory cell and molecular biology 2008;39(2):163-70.
2008: Ying-Ju Lai; Soni Pullamsetti; Eva Dony; Norbert Weissmann; Ghazwan Butrous; Gamal-Andre Banat; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.
American journal of respiratory and critical care medicine 2008;178(2):188-96.
2008: Martin R Wilkins; John Wharton; Friedrich Grimminger; H A Ghofrani
Phosphodiesterase inhibitors for the treatment of pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(1):198-209.
2008: István Vadász; Ralph Theo Schermuly; Hossein A Ghofrani; Sebastian Rummel; Susan Wehner; Inge Mühldorfer; Klaus P Schäfer; Werner Seeger; Rory Morty; Friedrich Grimminger; Norbert Weissmann
The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs.
Critical care medicine 2008;36(5):1543-50.
2008: Ute Buerke; Justin M Carter; Axel Schlitt; Martin Russ; Hendrik Schmidt; Ulf Sibelius; Ulrich Grandel; Friedrich Grimminger; Werner Seeger; Ursula Mueller-Werdan; Karl Werdan; Michael Buerke
Apoptosis contributes to septic cardiomyopathy and is improved by simvastatin therapy.
Shock (Augusta, Ga.) 2008;29(4):497-503.
2008: Eva Dony; Y-J Lai; Rio Dumitrascu; Soni Pullamsetti; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; D Flockerzi; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(3):599-610.
2008: Rio Dumitrascu; Silke Koebrich; Eva Dony; Norbert Weissmann; Rajkumar Savai; Soni Pullamsetti; Hossein A Ghofrani; Arun Samidurai; Heiko Traupe; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.
BMC pulmonary medicine 2008;8():25.
2008: Ladislau Kiss; Yasmin Röder; Jens Bier; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Direct eicosanoid profiling of the hypoxic lung by comprehensive analysis via capillary liquid chromatography with dual online photodiode-array and tandem mass-spectrometric detection.
Analytical and bioanalytical chemistry 2008;390(2):697-714.
2008: Kamila Kitowska; Dariusz Zakrzewicz; Melanie Königshoff; Izabella Chrobak; Friedrich Grimminger; Werner Seeger; Patrick Bulau; Oliver Eickelberg
Functional role and species-specific contribution of arginases in pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2008;294(1):L34-45.
2008: Mark Kirsch; Barbara Kemp-Harper; Norbert Weissmann; Friedrich Grimminger; Harald Schmidt
Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up-regulation of NO-cGMP signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):30-40.
2007: Frank Reichenberger; Markus G Kohstall; Timon Seeger; Horst Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function.
Respiratory physiology & neurobiology 2007;159(2):196-201.
2007: Frank Reichenberger; Robert Voswinckel; Beate Enke; M Rutsch; E El Fechtali; Thomas Schmehl; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Hossein A Ghofrani; Friedrich Grimminger; E Mayer; Werner Seeger
Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(5):922-7.
2007: Norbert Weissmann; Boris Gerigk; Ozlem Kocer; Matthias Nollen; Sascha Hackemack; Hossein A Ghofrani; Ralph Theo Schermuly; Ghazwan Butrous; Andreas Schulz; Markus Roth; Werner Seeger; Friedrich Grimminger
Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide.
Respiratory medicine 2007;101(10):2125-32.
2007: Manish Mittal; Markus Roth; Peter König; Simone Hofmann; Eva Dony; Parag Goyal; Anne-Christin Selbitz; Ralph Theo Schermuly; Hossein A Ghofrani; Grazyna Kwapiszewska; Wolfgang Kummer; Walter Klepetko; Mir Ali Reza Hoda; Ludger Fink; Jörg Hänze; Werner Seeger; Friedrich Grimminger; Harald Schmidt; Norbert Weissmann
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.
Circulation research 2007;101(3):258-67.
2007: Alexander Dietrich; Hermann Kalwa; Beate Fuchs; Friedrich Grimminger; Norbert Weissmann; Thomas Gudermann
In vivo TRPC functions in the cardiopulmonary vasculature.
Cell calcium 2007;42(2):233-44.
2007: Rajkumar Savai; Ralph Theo Schermuly; Soni Pullamsetti; Michael Schneider; Susanne Greschus; Hossein A Ghofrani; Heiko Traupe; Friedrich Grimminger; Gamal-Andre Banat
A combination hybrid-based vaccination/adoptive cellular therapy to prevent tumor growth by involvement of T cells.
Cancer research 2007;67(11):5443-53.
2007: Jörg Hänze; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Frank Rose
Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling.
Thrombosis and haemostasis 2007;97(5):774-87.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Grazyna Kwapiszewska; Rio Dumitrascu; Xia Tian; Norbert Weissmann; Hossein A Ghofrani; Christina Kaulen; Torsten R Dunkern; Christian Schudt; Robert Voswinckel; Jiang Zhou; Arun Samidurai; Walter Klepetko; Renate Paddenberg; Wolfgang Kummer; Werner Seeger; Friedrich Grimminger
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
Circulation 2007;115(17):2331-9.
2007: Andreas Günther; Beate Enke; Philipp Markart; P Hammerl; Harald Morr; Jürgen Behr; Gerd Stähler; Werner Seeger; Friedrich Grimminger; I Leconte; S Roux; Hossein A Ghofrani
Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(4):713-9.
2007: Martina Barbara Schaefer; Juliane Ott; Andrea Mohr; Ming Hua Bi; Andrea Grosz; Norbert Weissmann; Satoshi Ishii; Friedrich Grimminger; Werner Seeger; Konstantin Mayer
Immunomodulation by n-3- versus n-6-rich lipid emulsions in murine acute lung injury--role of platelet-activating factor receptor.
Critical care medicine 2007;35(2):544-54.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Susanne C Breitenbach; Norbert Weissmann; Hossein A Ghofrani; Friedrich Grimminger; Sigrid M Nilius; Karsten Schrör; Jutta M Kirchrath; Werner Seeger; Frank Rose
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs.
Respiratory research 2007;8():4.
2007: Bernhard Rosengarten; Mirko Hecht; Dieter Auch; Hossein A Ghofrani; Ralph Theo Schermuly; Friedrich Grimminger; Manfred Kaps
Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats.
Cerebrovascular diseases (Basel, Switzerland) 2007;23(2-3):140-7.
2007: Patrick Bulau; Dariusz Zakrzewicz; Kamila Kitowska; James Leiper; Andreas Gunther; Friedrich Grimminger; Oliver Eickelberg
Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA.
American journal of physiology. Lung cellular and molecular physiology 2007;292(1):L18-24.
2006: Norbert Weissmann; Alexander Dietrich; Beate Fuchs; Hermann Kalwa; Mahmut Ay; Rio Dumitrascu; Andrea Olschewski; Ursula Storch; Michael Mederos y Schnitzler; Hossein A Ghofrani; Ralph Theo Schermuly; Olaf Pinkenburg; Werner Seeger; Friedrich Grimminger; Thomas Gudermann
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19093-8.
2006: Hossein A Ghofrani; S Rosenkranz; Friedrich Grimminger
[Future aspects of the treatment of pulmonary arterial hypertension].
Deutsche medizinische Wochenschrift (1946) 2006;131(49 Suppl 9):S338-40.
2006: Hossein A Ghofrani; Friedrich Grimminger
[Treatment of pulmonary arterial hypertension: phosphodiesterase-5 inhibitors].
Deutsche medizinische Wochenschrift (1946) 2006;131(49 Suppl 9):S311-4.
2006: Robert Voswinckel; Beate Enke; Frank Reichenberger; Markus G Kohstall; André Kreckel; Stefanie Krick; Henning Gall; Tobias Gessler; Thomas Schmehl; Hossein A Ghofrani; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Werner Seeger; Horst Olschewski
Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.
Journal of the American College of Cardiology 2006;48(8):1672-81.
2006: Hossein A Ghofrani; Robert Voswinckel; Frank Reichenberger; Norbert Weissmann; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies.
Cardiovascular research 2006;72(1):30-40.
2006: Ali O Yildirim; Patrick Bulau; Dariusz Zakrzewicz; Kamila Kitowska; Norbert Weissmann; Friedrich Grimminger; Rory Morty; Oliver Eickelberg
Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases.
American journal of respiratory cell and molecular biology 2006;35(4):436-43.
2006: Norbert Weissmann; Friedrich Grimminger; Werner Seeger
Hypoxia in lung vascular biology and disease.
Cardiovascular research 2006;71(4):618-9.
2006: Frank Reichenberger; Robert Voswinckel; E Steveling; Beate Enke; André Kreckel; Horst Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Sildenafil treatment for portopulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(3):563-7.
2006: Norbert Weissmann; Natascha Sommer; Ralph Theo Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Oxygen sensors in hypoxic pulmonary vasoconstriction.
Cardiovascular research 2006;71(4):620-9.
2006: Hossein A Ghofrani; Ian H Osterloh; Friedrich Grimminger
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.
Nature reviews. Drug discovery 2006;5(8):689-702.
2006: Hossein A Ghofrani; R T Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
[Reverse remodeling -- paradigm shift in the treatment of pulmonary hypertension].
Deutsche medizinische Wochenschrift (1946) 2006;131(16):871-4.
2006: Robert Voswinckel; K Ahlbrecht; J C Wolff; Norbert Weissmann; Heinz Fehrenbach; A O Yildirim; Friedrich Grimminger; Werner Seeger
[Pulmonary tissue regeneration -- a hope for the future].
Deutsche medizinische Wochenschrift (1946) 2006;131(16):865-8.
2006: Soni Pullamsetti; Daniel Maring; Hossein A Ghofrani; Konstantin Mayer; Norbert Weissmann; Bernhard Rosengarten; Martin Lehner; Christian Schudt; Rainer Boer; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Thrombosis and haemostasis 2006;95(4):720-7.
2006: Konstantin Mayer; M Schaefer; H Walmrath; Friedrich Grimminger; Werner Seeger
[Nutrition and immunonutrition in septic patients].
Der Internist 2006;47(4):374, 376-82.
2006: Peter Pokreisz; Ingrid Fleming; Ladislau Kiss; Eduardo Barbosa-Sicard; Beate Fisslthaler; John R Falck; Bruce D Hammock; In-Hae Kim; Zsolt László Szelid; Pieter Vermeersch; Hilde Gillijns; Marijke Pellens; Friedrich Grimminger; Anton-Jan van Zonneveld; Désiré Collen; Rudi Busse; Stefan Janssens
Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.
Hypertension 2006;47(4):762-70.
2006: Norbert Weissmann; Stefanie Zeller; Rolf Schäfer; Carmen Turowski; Mahmut Ay; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Ludger Fink; Werner Seeger; Friedrich Grimminger
Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction.
American journal of respiratory cell and molecular biology 2006;34(4):505-13.
2006: Aparna Renigunta; Gabriela Krasteva; Peter König; Frank Rose; Walter Klepetko; Friedrich Grimminger; Werner Seeger; Jörg Hänze
DNA transfer into human lung cells is improved with Tat-RGD peptide by caveoli-mediated endocytosis.
Bioconjugate chemistry 2006;17(2):327-34.
2006: Rajkumar Savai; Ralph Theo Schermuly; Michael Schneider; Soni Pullamsetti; Friedrich Grimminger; Werner Seeger; Gamal-Andre Banat
Hybrid-primed lymphocytes and hybrid vaccination prevent tumor growth of lewis lung carcinoma in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(2):175-87.
2006: Katja Hattar; Ulrich Grandel; Alexander Moeller; Ludger Fink; Julia Iglhaut; Thomas Hartung; Siegfried Morath; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-[alpha] in mediating LTA-induced interleukin-8 generation.
Critical care medicine 2006;34(3):835-41.
2006: Aparna Renigunta; Christiane Hild; Frank Rose; Walter Klepetko; Friedrich Grimminger; Werner Seeger; Jörg Hänze
Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia.
FEBS letters 2006;580(3):900-3.
2006: Helmut Grimm; Norbert Mertes; Christiane Goeters; Ewald Schlotzer; Konstantin Mayer; Friedrich Grimminger; Peter Fürst
Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients.
European journal of nutrition 2006;45(1):55-60.
2006: Robert Voswinckel; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Inhaled treprostinil [corrected] for treatment of chronic pulmonary arterial hypertension.
Annals of internal medicine 2006;144(2):149-50.
2006: Rio Dumitrascu; Norbert Weissmann; Hossein A Ghofrani; Eva Dony; Knut Beuerlein; Harald Schmidt; Johannes-Peter Stasch; Mark J Gnoth; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling.
Circulation 2006;113(2):286-95.
2006: Ralph Theo Schermuly; Andreas Schulz; Hossein A Ghofrani; Christina Susanne Breitenbach; Norbert Weissmann; Michael Hildebrand; Julia Kurz; Friedrich Grimminger; Werner Seeger
Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: rapid tolerance development.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2006;19(3):353-63.
2006: Norbert Weissmann; Ralph Theo Schermuly; Hossein A Ghofrani; Jörg Hänze; Parag Goyal; Friedrich Grimminger; Werner Seeger
Hypoxic pulmonary vasoconstriction--triggered by an increase in reactive oxygen species?
Novartis Foundation symposium 2006;272():196-208; discussion 208-17.
2006: Bernhard Rosengarten; Ralph Theo Schermuly; Robert Voswinckel; Markus G Kohstall; Horst Olschewski; Norbert Weissmann; Werner Seeger; Manfred Kaps; Friedrich Grimminger; Hossein A Ghofrani
Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension.
Cerebrovascular diseases (Basel, Switzerland) 2006;21(3):194-200.
2006: Ulrich Grandel; Robin Benkelmann; Michael Buerke; Ladislau Kiss; Katja Hattar; Konstantin Mayer; Martina Heep; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Free arachidonic versus eicosapentaenoic acid differentially influences the potency of bacterial exotoxins to provoke myocardial depression in isolated rat hearts.
Critical care medicine 2006;34(1):118-26.
2006: Bastian Eul; Frank Rose; Stefanie Krick; Rajkumar Savai; Parag Goyal; Walter Klepetko; Friedrich Grimminger; Norbert Weissmann; Werner Seeger; Jörg Hänze
Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(1):163-5.
2005: Nazzareno Galiè; Hossein A Ghofrani; Adam Torbicki; Robyn J Barst; Lewis J Rubin; David B Badesch; Thomas Fleming; Tamiza Parpia; Gary Burgess; Angelo Branzi; Friedrich Grimminger; Marcin Kurzyna; Gérald Simonneau
Sildenafil citrate therapy for pulmonary arterial hypertension.
The New England journal of medicine 2005;353(20):2148-57.
2005: Ralph Theo Schermuly; Eva Dony; Hossein A Ghofrani; Soni Pullamsetti; Rajkumar Savai; Markus Roth; Akylbek Sydykov; Ying Ju Lai; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Reversal of experimental pulmonary hypertension by PDGF inhibition.
The Journal of clinical investigation 2005;115(10):2811-21.
2005: Rajkumar Savai; Joachim C Wolf; Susanne Greschus; Bastian Eul; Ralph Theo Schermuly; Jörg Hänze; Robert Voswinckel; Alexander C Langheinrich; Friedrich Grimminger; Heiko Traupe; Werner Seeger; Frank Rose
Analysis of tumor vessel supply in Lewis lung carcinoma in mice by fluorescent microsphere distribution and imaging with micro- and flat-panel computed tomography.
The American journal of pathology 2005;167(4):937-46.
2005: István Vadász; Rory Morty; Andrea Olschewski; Melanie Königshoff; Markus G Kohstall; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase.
American journal of respiratory cell and molecular biology 2005;33(4):343-54.
2005: Katja Hattar; Sandra van Bürck; Annette Bickenbach; Ulrich Grandel; Ulrich A Maus; Jürgen Lohmeyer; Elena Csernok; Thomas Hartung; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation.
Journal of leukocyte biology 2005;78(4):992-1000.
2005: Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Imatinib for the treatment of pulmonary arterial hypertension.
The New England journal of medicine 2005;353(13):1412-3.
2005: Norbert Weissmann; Daniel Manz; Daniela Buchspies; Stephan Keller; Tanja Mehling; Robert Voswinckel; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Ludger Fink; Werner Seeger; Max Gassmann; Friedrich Grimminger
Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
Thrombosis and haemostasis 2005;94(3):630-8.
2005: Georg Friese; Jürgen Lohmeyer; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
[HIV-associated pulmonary hypertension ].
Herz 2005;30(6):481-5.
2005: Ulrich Grandel; Michael Hopf; Michael Buerke; Katja Hattar; Martina Heep; Ludger Fink; Rainer M Bohle; Siegfried Morath; Thomas Hartung; Soni Pullamsetti; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts.
Circulation 2005;112(5):691-8.
2005: Philipp Markart; L Hundack; Ardeschir Ghofrani; Friedrich Grimminger; Werner Seeger; Andreas Günther
[Idiopathic interstitial pneumonias: pathomechanisms and therapeutic options].
Pneumologie (Stuttgart, Germany) 2005;59(8):554-61.
2005: Rajkumar Savai; Ralph Theo Schermuly; Robert Voswinckel; Aparna Renigunta; Bernd Reichmann; Bastian Eul; Friedrich Grimminger; Werner Seeger; Frank Rose; Jörg Hänze
HIF-1alpha attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model.
International journal of oncology 2005;27(2):393-400.
2005: Ralph Theo Schermuly; Hüseyin Yilmaz; Hossein A Ghofrani; Kathrin Woyda; Soni Pullamsetti; Andreas Schulz; Tobias Gessler; Rio Dumitrascu; Norbert Weissmann; Friedrich Grimminger; Werner Seeger
Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2005;172(3):358-63.
2005: Soni Pullamsetti; Ladislau Kiss; Hossein A Ghofrani; Robert Voswinckel; Peter Haredza; Walter Klepetko; Clemens Aigner; Ludger Fink; Jai Prakash Muyal; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1175-7.
2005: Hossein Ardeschir Ghofrani; Robert Voswinckel; Frank Reichenberger; Friedrich Grimminger; Werner Seeger
[Emerging therapies for the treatment of pulmonary arterial hypertension].
Herz 2005;30(4):296-302.
2005: Stefanie Krick; Jörg Hänze; Bastian Eul; Rajkumar Savai; Ulrike Seay; Friedrich Grimminger; Jürgen Lohmeyer; Walter Klepetko; Werner Seeger; Frank Rose
Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1alpha and an autocrine angiotensin system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):857-9.
2005: Stefanie Krick; Bastian Eul; Jörg Hänze; Rajkumar Savai; Friedrich Grimminger; Werner Seeger; Frank Rose
Role of hypoxia-inducible factor-1alpha in hypoxia-induced apoptosis of primary alveolar epithelial type II cells.
American journal of respiratory cell and molecular biology 2005;32(5):395-403.
2005: Parag Goyal; Norbert Weissmann; Frank Rose; Friedrich Grimminger; Hans J Schäfers; Werner Seeger; Jörg Hänze
Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells.
Biochemical and biophysical research communications 2005;329(1):32-9.
2005: Horst Olschewski; Ardeschir Ghofrani; Beate Enke; Frank Reichenberger; Robert Voswinckel; André Kreckel; Stefanie Ghofrani; Ralph Wiedemann; R Schulz; Friedrich Grimminger; Werner Seeger
[Therapy of pulmonary arterial hypertension].
Der Internist 2005;46(3):341-9.
2005: István Vadász; Rory Morty; Markus G Kohstall; Andrea Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome?
American journal of respiratory and critical care medicine 2005;171(5):469-79.
2005: Soni Pullamsetti; Stefanie Krick; Hüseyin Yilmaz; Hossein A Ghofrani; Christian Schudt; Norbert Weissmann; Beate Fuchs; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.
Respiratory research 2005;6():128.
2005: Norbert Weissmann; Nermin Kuzkaya; Beate Fuchs; Vedat Tiyerili; Rolf Schäfer; Hartwig Schütte; Hossein A Ghofrani; Ralph Theo Schermuly; Christian Schudt; Akylbek Sydykov; Bakytbek Egemnazarow; Werner Seeger; Friedrich Grimminger
Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy.
Respiratory research 2005;6():86.
2005: Ralph Theo Schermuly; Christiane Inholte; Hossein A Ghofrani; Henning Gall; Norbert Weissmann; Andreas Weidenbach; Werner Seeger; Friedrich Grimminger
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.
Respiratory research 2005;6():76.
2004: Reinhold Schmidt; T Luboeinski; Philipp Markart; Clemens Ruppert; C Daum; Friedrich Grimminger; Werner Seeger; Andreas Günther
Alveolar antioxidant status in patients with acute respiratory distress syndrome.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(6):994-9.
2004: Hossein A Ghofrani; Robert Voswinckel; Frank Reichenberger; Horst Olschewski; Peter Haredza; Burcu Karadaş; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study.
Journal of the American College of Cardiology 2004;44(7):1488-96.
2004: Malgorzata Wygrecka; Philipp Markart; Clemens Ruppert; Tim Kuchenbuch; Ludger Fink; Rainer M Bohle; Friedrich Grimminger; Werner Seeger; Andreas Günther
Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application.
Thrombosis and haemostasis 2004;92(3):529-40.
2004: Hossein A Ghofrani; Frank Reichenberger; Markus G Kohstall; Eike Mrosek; Timon Seeger; Horst Olschewski; Werner Seeger; Friedrich Grimminger
Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial.
Annals of internal medicine 2004;141(3):169-77.
2004: Hossein A Ghofrani; Joanna Pepke-Zaba; Joan A Barbera; Richard N Channick; Anne M Keogh; Miguel A Gomez-Sanchez; Meinhard Kneussl; Friedrich Grimminger
Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension.
Journal of the American College of Cardiology 2004;43(12 Suppl S):68S-72S.
2004: Parag Goyal; Norbert Weissmann; Friedrich Grimminger; Cornelia Hegel; Lucius Bader; Frank Rose; Ludger Fink; Hossein A Ghofrani; Ralph Theo Schermuly; Harald Schmidt; Werner Seeger; Jörg Hänze
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species.
Free radical biology & medicine 2004;36(10):1279-88.
2004: Ralph Theo Schermuly; Klaus Peter Kreisselmeier; Hossein A Ghofrani; Arun Samidurai; Soni Pullamsetti; Norbert Weissmann; Christian Schudt; Leander Ermert; Werner Seeger; Friedrich Grimminger
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Circulation research 2004;94(8):1101-8.
2004: Norbert Weissmann; Henrik Vogels; Ralph Theo Schermuly; Hossein A Ghofrani; Jörg Hänze; Ludger Fink; Frank Rose; Werner Seeger; Friedrich Grimminger
Measurement of exhaled hydrogen peroxide from rabbit lungs.
Biological chemistry 2004;385(3-4):259-64.
2004: Hossein A Ghofrani; Georg Friese; Thomas Discher; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger; Jürgen Lohmeyer
Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(2):321-6.
2004: Norbert Weissmann; Ercan Akkayagil; Karin Quanz; Ralph Theo Schermuly; Hossein A Ghofrani; Ludger Fink; Jörg Hänze; Frank Rose; Werner Seeger; Friedrich Grimminger
Basic features of hypoxic pulmonary vasoconstriction in mice.
Respiratory physiology & neurobiology 2004;139(2):191-202.
2004: Reinhold Schmidt; Christoph Schäfer; Thomas Luboeinski; Alexander Löckinger; Gerd Hermle; Friedrich Grimminger; Werner Seeger; Ardeschir Ghofrani; Hartwig Schütte; Andreas Günther
Increase in alveolar antioxidant levels in hyperoxic and anoxic ventilated rabbit lungs during ischemia.
Free radical biology & medicine 2004;36(1):78-89.
2004: Heidrun Muth; Ulrich A Maus; Malgorzata Wygrecka; Jürgen Lohmeyer; Friedrich Grimminger; Werner Seeger; Andreas Günther
Pro- and antifibrinolytic properties of human pulmonary microvascular versus artery endothelial cells: impact of endotoxin and tumor necrosis factor-alpha.
Critical care medicine 2004;32(1):217-26.
2004: Ralph Theo Schermuly; Klaus P Kreisselmeier; Hossein A Ghofrani; Hüseyin Yilmaz; Ghazwan Butrous; Leander Ermert; Monika Ermert; Norbert Weissmann; Frank Rose; Andreas Guenther; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;169(1):39-45.
2003: Jörg Hänze; Bastian Eul; Rajkumar Savai; Stefanie Krick; Parag Goyal; Friedrich Grimminger; Werner Seeger; Frank Rose
RNA interference for HIF-1alpha inhibits its downstream signalling and affects cellular proliferation.
Biochemical and biophysical research communications 2003;312(3):571-7.
2003: Oliver Eickelberg; Michael E Yeager; Friedrich Grimminger
The tantalizing triplet of pulmonary hypertension-BMP receptors, serotonin receptors, and angiopoietins.
Cardiovascular research 2003;60(3):465-7.
2003: Frank Rose; Katja Hattar; Sybille Gakisch; Friedrich Grimminger; Horst Olschewski; Werner Seeger; Annette Tschuschner; Ralph Theo Schermuly; Norbert Weissmann; Jörg Hanze; Ulf Sibelius; Hossein A Ghofrani
Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost.
Thrombosis and haemostasis 2003;90(6):1141-9.
2003: Andreas Günther; Norbert Lübke; Monika Ermert; Ralph Theo Schermuly; Norbert Weissmann; Andreas Breithecker; Philipp Markart; Clemens Ruppert; Karin Quanz; Leander Ermert; Friedrich Grimminger; Werner Seeger
Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits.
American journal of respiratory and critical care medicine 2003;168(11):1358-65.
2003: Norbert Weissmann; Nadine Ebert; Marit Ahrens; Hossein A Ghofrani; Ralph Theo Schermuly; Jörg Hänze; Ludger Fink; Frank Rose; Jörg Conzen; Werner Seeger; Friedrich Grimminger
Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2003;29(6):721-32.
2003: Konstantin Mayer; Sandra Meyer; Marion Reinholz-Muhly; Ulrich A Maus; Martina Merfels; Jürgen Lohmeyer; Friedrich Grimminger; Werner Seeger
Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4837-43.
2003: Konstantin Mayer; Christine Fegbeutel; Katja Hattar; Ulf Sibelius; Hans-Joachim Krämer; Kai-Uwe Heuer; Bettina Temmesfeld-Wollbrück; Stephanie Gokorsch; Friedrich Grimminger; Werner Seeger
Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation.
Intensive care medicine 2003;29(9):1472-81.
2003: Ralph Theo Schermuly; H Leuchte; Hossein A Ghofrani; Norbert Weissmann; Frank Rose; Markus G Kohstall; Horst Olschewski; Christian Schudt; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Zardaverine and aerosolised iloprost in a model of acute respiratory failure.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(2):342-7.
2003: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; André Kreckel; Norbert Weissmann; Stefanie Ghofrani; Beate Enke; Werner Seeger; Friedrich Grimminger
Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension.
Journal of the American College of Cardiology 2003;42(1):158-64.
2003: Konstantin Mayer; Stephanie Gokorsch; Christine Fegbeutel; Katja Hattar; Simone Rosseau; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis.
American journal of respiratory and critical care medicine 2003;167(10):1321-8.
2003: Monika Ermert; C Pantazis; Hans-Rainer Duncker; Friedrich Grimminger; Werner Seeger; Leander Ermert
In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue.
Cytokine 2003;22(3-4):89-100.
2003: Clemens Ruppert; Carolin Pucker; Philipp Markart; Kerstin Seibold; Ariane Bagheri; Friedrich Grimminger; Werner Seeger; Andreas Günther
Impact of surface tension on the conversion rate of large to small surfactant aggregates.
Biophysical chemistry 2003;104(1):229-38.
2003: Hossein A Ghofrani; Ralph Theo Schermuly; Frank Rose; Ralph Wiedemann; Markus G Kohstall; André Kreckel; Horst Olschewski; Norbert Weissmann; Beate Enke; Stefanie Ghofrani; Werner Seeger; Friedrich Grimminger
Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension.
American journal of respiratory and critical care medicine 2003;167(8):1139-41.
2003: Richard Schulz; Christine Fegbeutel; Andre Althoff; Heiko Traupe; Friedrich Grimminger; Werner Seeger
Central sleep apnoea and unilateral diaphragmatic paralysis associated with vertebral artery compression of the medulla oblongata.
Journal of neurology 2003;250(4):503-5.
2003: Hartwig Schütte; Alexander Schell; Christoph Schäfer; Ardeschir Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Subthreshold doses of nebulized prostacyclin and rolipram synergistaically protect against lung ischemia-reperfusion.
Transplantation 2003;75(6):814-21.
2003: Ulf Sibelius; Ulrich Grandel; Michael Buerke; Ladislau Kiss; Pascal Klingenberger; Martina Heep; Emmanoyil Bournelis; Werner Seeger; Friedrich Grimminger
Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
Critical care medicine 2003;31(3):683-8.
2003: Norbert Weissmann; Matthias Nollen; Boris Gerigk; Hossein Ardeschir Ghofrani; Ralph Theo Schermuly; Andreas Gunther; Karin Quanz; Ludger Fink; Jörg Hänze; Frank Rose; Werner Seeger; Friedrich Grimminger
Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H931-8.
2003: Lea Ann Dailey; Thomas Schmehl; Tobias Gessler; Matthias Wittmar; Friedrich Grimminger; Werner Seeger; Thomas Kissel
Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features.
Journal of controlled release : official journal of the Controlled Release Society 2003;86(1):131-44.
2003: Ulrich Grandel; Friedrich Grimminger
Endothelial responses to bacterial toxins in sepsis.
Critical reviews in immunology 2003;23(4):267-99.
2003: Clemens Ruppert; Philipp Markart; Reinhold Schmidt; Friedrich Grimminger; Werner Seeger; Claus-Michael Lehr; Andreas Günther
Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin.
Thrombosis and haemostasis 2003;89(1):53-64.
2003: Clemens Ruppert; Carolin Pucker; Philipp Markart; Reinhold Schmidt; Friedrich Grimminger; Werner Seeger; Jörg Stürzebecher; Andreas Günther
Selective inhibition of large-to-small surfactant aggregate conversion by serine protease inhibitors of the bis-benzamidine type.
American journal of respiratory cell and molecular biology 2003;28(1):95-102.
2003: Philipp Markart; Clemens Ruppert; Friedrich Grimminger; Werner Seeger; Andreas Günther
Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C.
American journal of physiology. Lung cellular and molecular physiology 2003;284(1):L69-76.
2002: Horst Olschewski; Ardeschir Ghofrani; Ralph Wiedemann; Frank Rose; Beate Enke; Tobias Gessler; Robert Voswinckel; Markus G Kohstall; Friedrich Grimminger; Werner Seeger
[Pulmonary hypertension].
Der Internist 2002;43(12):1498, 1501-9.
2002: Hossein A Ghofrani; Horst Olschewski; Werner Seeger; Friedrich Grimminger
[Sildenafil for treatment of severe pulmonary hypertension and commencing right-heart failure].
Pneumologie (Stuttgart, Germany) 2002;56(11):665-72.
2002: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; Norbert Weissmann; Christian Schudt; Hermann Tenor; Werner Seeger; Friedrich Grimminger
Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension.
Critical care medicine 2002;30(11):2489-92.
2002: Ralph Theo Schermuly; Andreas Schulz; Hossein A Ghofrani; Arne Meidow; Frank Rose; Axel Roehl; Norbert Weissmann; Michael Hildebrand; Julia Kurz; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs.
The Journal of pharmacology and experimental therapeutics 2002;303(2):741-5.
2002: Reinhold Schmidt; U Meier; Philipp Markart; Friedrich Grimminger; Hans-Georg Velcovsky; Harald Morr; Werner Seeger; Andreas Günther
Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease.
American journal of physiology. Lung cellular and molecular physiology 2002;283(5):L1079-85.
2002: Diethard Pruefer; Joachim Makowski; Martin Schnell; Ute Buerke; Manfred Dahm; Hellmut Oelert; Ulf Sibelius; Ulrich Grandel; Friedrich Grimminger; Werner Seeger; Jürgen Meyer; Harald Darius; Michael Buerke
Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha-toxin.
Circulation 2002;106(16):2104-10.
2002: Ulf Sibelius; Katja Hattar; Sabine Hoffmann; Konstantin Mayer; Ulrich Grandel; Angelika Schenkel; Werner Seeger; Friedrich Grimminger
Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
Critical care medicine 2002;30(10):2306-12.
2002: Frank Rose; Friedrich Grimminger; Jutta Appel; Mathias Heller; Volker Pies; Norbert Weissmann; Ludger Fink; Sebastian Schmidt; Stefanie Krick; Gieri Camenisch; Max Gassmann; Werner Seeger; Jörg Hänze
Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1660-1.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Norbert Weissmann; Andreas Gunther; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial.
Lancet 2002;360(9337):895-900.
2002: Frank Rose; Bernd Guthmann; Tobias Tenenbaum; Ludger Fink; Ardeschir Ghofrani; Norbert Weissmann; Peter König; Leander Ermert; Gabriele Dahlem; Joerg Haenze; Wolfgang Kummer; Werner Seeger; Friedrich Grimminger
Apical, but not basolateral, endotoxin preincubation protects alveolar epithelial cells against hydrogen peroxide-induced loss of barrier function: the role of nitric oxide synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1474-81.
2002: Konstantin Mayer; Martina Merfels; Marion Muhly-Reinholz; Stephanie Gokorsch; Simone Rosseau; Jürgen Lohmeyer; Nicole Schwarzer; Matthias Krüll; Norbert Suttorp; Friedrich Grimminger; Werner Seeger
Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation.
American journal of physiology. Heart and circulatory physiology 2002;283(2):H811-8.
2002: Clemens Ruppert; Reinhold Schmidt; Friedrich Grimminger; Yasuhiro Suzuki; Werner Seeger; Claus-Michael Lehr; Andreas Günther
Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin.
Bioconjugate chemistry 2002;13(4):804-11.
2002: W George; Friedrich Grimminger; B Krause
[Communication center in public health].
Versicherungsmedizin / herausgegeben von Verband der Lebensversicherungs-Unternehmen e.V. und Verband der Privaten Krankenversicherung e.V 2002;54(2):84-8.
2002: Katja Hattar; Annette Bickenbach; Elena Csernok; Simone Rosseau; Ulrich Grandel; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Wegener's granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine cell activation.
Journal of leukocyte biology 2002;71(6):996-1004.
2002: Konstantin Mayer; Reinhold Schmidt; Marion Muhly-Reinholz; Tina Bögeholz; Stephanie Gokorsch; Friedrich Grimminger; Werner Seeger
In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFalpha impact of omega-3 versus omega-6 fatty acids.
Journal of lipid research 2002;43(6):944-51.
2002: Dieter Walmrath; Friedrich Grimminger; D Pappert; C Knothe; U Obertacke; Albert Benzing; Andreas Günther; Thomas Schmehl; H Leuchte; Werner Seeger
Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on gas exchange and haemodynamics.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(5):805-10.
2002: Andreas Günther; Reinhold Schmidt; J Harodt; Thomas Schmehl; Dieter Walmrath; Clemens Ruppert; Friedrich Grimminger; Werner Seeger
Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(5):797-804.
2002: Peter Mayser; Konstantin Mayer; Mojgan Mahloudjian; Steffen Benzing; Hans-Joachim Krämer; Wolf-Bernhard Schill; Werner Seeger; Friedrich Grimminger
A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis.
JPEN. Journal of parenteral and enteral nutrition 2002;26(3):151-8.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension.
Annals of internal medicine 2002;136(7):515-22.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Norbert Weissmann; Ralph Theo Schermuly; Karin Quanz; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Lung cGMP release subsequent to NO inhalation in pulmonary hypertension: responders versus nonresponders.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):664-71.
2002: Richard Schulz; G Baseler; Hossein A Ghofrani; Friedrich Grimminger; Horst Olschewski; Werner Seeger
Nocturnal periodic breathing in primary pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):658-63.
2002: Katja Hattar; Ulrich Grandel; Annette Bickenbach; Andreas Schwarting; Werner-Johannes Mayet; Juergen Bux; Sönke Jessen; Claus Fischer; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):3057-64.
2002: Jörg Hänze; David A Groneberg; Frank Rose; Anika Hanisch; Jörg Dötsch; Christian Peiser; Werner Seeger; Wolfgang Rascher; Axel Fischer; Friedrich Grimminger
Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia.
Biochemical and biophysical research communications 2002;291(5):1160-5.
2002: Ulrich Grandel; Mathias Reutemann; Ladislau Kiss; Michael Buerke; Ludger Fink; Emmanoyil Bournelis; Martina Heep; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Staphylococcal alpha-toxin provokes neutrophil-dependent cardiac dysfunction: role of ICAM-1 and cys-leukotrienes.
American journal of physiology. Heart and circulatory physiology 2002;282(3):H1157-65.
2002: Reinhold Schmidt; Wolfram Steinhilber; Clemens Ruppert; Christina Daum; Friedrich Grimminger; Werner Seeger; Andreas Günther
An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid.
American journal of respiratory and critical care medicine 2002;165(4):470-4.
2002: Frank Rose; Gabriele Dahlem; Bernd Guthmann; Friedrich Grimminger; Ulrich A Maus; Jörg Hänze; Nils Duemmer; Ulrich Grandel; Werner Seeger; Hossein A Ghofrani
Mediator generation and signaling events in alveolar epithelial cells attacked by S. aureus alpha-toxin.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L207-14.
2002: Tobias Gessler; Thomas Schmehl; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Aerosolized vasodilators in pulmonary hypertension.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2002;15(2):117-22.
2002: Peter Mayser; Helmut Grimm; Friedrich Grimminger
n-3 fatty acids in psoriasis.
The British journal of nutrition 2002;87 Suppl 1():S77-82.
2002: Konstantin Mayer; Helmut Grimm; Friedrich Grimminger; Werner Seeger
Parenteral nutrition with n-3 lipids in sepsis.
The British journal of nutrition 2002;87 Suppl 1():S69-75.
2002: Michael Buerke; Ulf Sibelius; Ulrich Grandel; Ute Buerke; Friedrich Grimminger; Werner Seeger; Jürgen Meyer; Harald Darius
Staphylococcus aureus alpha toxin mediates polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction.
Shock (Augusta, Ga.) 2002;17(1):30-5.
2002: Ludger Fink; Stephanie Kohlhoff; Maria Magdalena Stein; Jörg Hänze; Norbert Weissmann; Frank Rose; Ercan Akkayagil; Daniel Manz; Friedrich Grimminger; Werner Seeger; Rainer M Bohle
cDNA array hybridization after laser-assisted microdissection from nonneoplastic tissue.
The American journal of pathology 2002;160(1):81-90.
2002: Richard Schulz; Christoph Hummel; Sabine Heinemann; Werner Seeger; Friedrich Grimminger
Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia.
American journal of respiratory and critical care medicine 2002;165(1):67-70.
2001: D Walmrath; Friedrich Grimminger; W Seeger
[Severe sepsis--new therapeutic options].
Der Internist 2001;42(12):1619-20, 1623-30.
2001: Horst Olschewski; Frank Rose; Ekkehard Grünig; H A Ghofrani; Dieter Walmrath; R Schulz; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger
Cellular pathophysiology and therapy of pulmonary hypertension.
The Journal of laboratory and clinical medicine 2001;138(6):367-77.
2001: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; H Leuchte; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2001;281(6):L1361-8.
2001: R Schulz; W Seeger; Friedrich Grimminger
Serum nitrite/nitrate levels in obstructive sleep apnea.
American journal of respiratory and critical care medicine 2001;164(10 Pt 1):1997-8.
2001: Ralph Theo Schermuly; E Krupnik; Hermann Tenor; Christian Schudt; Norbert Weissmann; Frank Rose; Friedrich Grimminger; Werner Seeger; Dieter Walmrath; Hossein A Ghofrani
Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity.
American journal of respiratory and critical care medicine 2001;164(9):1694-700.
2001: Horst Olschewski; Andrea Olschewski; Frank Rose; Ralph Theo Schermuly; Hartwig Schütte; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Physiologic basis for the treatment of pulmonary hypertension.
The Journal of laboratory and clinical medicine 2001;138(5):287-97.
2001: Hartwig Schütte; Martin Witzenrath; Konstantin Mayer; Simone Rosseau; Werner Seeger; Friedrich Grimminger
Short-term "preconditioning" with inhaled nitric oxide protects rabbit lungs against ischemia-reperfusion injury.
Transplantation 2001;72(8):1363-70.
2001: Ralph Wiedemann; Hossein A Ghofrani; Norbert Weissmann; Ralph Theo Schermuly; Karin Quanz; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation.
Journal of the American College of Cardiology 2001;38(4):1130-6.
2001: Ralph Theo Schermuly; Norbert Weissmann; Beate Enke; Hossein A Ghofrani; W G Forssmann; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication.
American journal of respiratory cell and molecular biology 2001;25(2):219-25.
2001: Hartwig Schütte; Konstantin Mayer; H Burger; Martin Witzenrath; Tobias Gessler; Werner Seeger; Friedrich Grimminger
Endogenous nitric oxide synthesis and vascular leakage in ischemic-reperfused rabbit lungs.
American journal of respiratory and critical care medicine 2001;164(3):412-8.
2001: Norbert Weissmann; Friedrich Grimminger; Andrea Olschewski; W Seeger
Hypoxic pulmonary vasoconstriction: a multifactorial response?
American journal of physiology. Lung cellular and molecular physiology 2001;281(2):L314-7.
2001: Hartwig Schütte; Alexander Löckinger; Werner Seeger; Friedrich Grimminger
Aerosolized PGE1, PGI2 and nitroprusside protect against vascular leakage in lung ischaemia-reperfusion.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;18(1):15-22.
2001: A Günther; Dieter Walmrath; Friedrich Grimminger; W Seeger
Pathophysiology of acute lung injury.
Seminars in respiratory and critical care medicine 2001;22(3):247-58.
2001: Richard Schulz; Horst Olschewski; Friedrich Grimminger; Werner Seeger
[Obstructive sleep apnea and cardiovascular diseases--hypothesis on the pathophysiological interlinks].
Pneumologie (Stuttgart, Germany) 2001;55(6):295-301.
2001: Katja Hattar; Ludger Fink; K Fietzner; B Himmel; Friedrich Grimminger; Werner Seeger; Ulf Sibelius
Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6287-93.
2001: Hossein A Ghofrani; Markus G Kohstall; Norbert Weissmann; Thomas Schmehl; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Alveolar epithelial barrier functions in ventilated perfused rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(5):L896-904.
2001: Ralph Theo Schermuly; Andreas Günther; Monika Ermert; Leander Ermert; Hossein A Ghofrani; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Conebulization of surfactant and urokinase restores gas exchange in perfused lungs with alveolar fibrin formation.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L792-800.
2001: Norbert Weissmann; S Winterhalder; Matthias Nollen; Robert Voswinckel; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L638-45.
2001: Frank Rose; S A Zeller; Trinad Chakraborty; Eugen Domann; thomas machleidt; M Kronke; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Human endothelial cell activation and mediator release in response to Listeria monocytogenes virulence factors.
Infection and immunity 2001;69(2):897-905.
2001: Alexander Löckinger; Hartwig Schütte; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Protection against gas exchange abnormalities by pre-aerosolized PGE1, iloprost and nitroprusside in lung ischemia-reperfusion.
Transplantation 2001;71(2):185-93.
2001: Andreas Günther; Clemens Ruppert; Reinhold Schmidt; Philipp Markart; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Surfactant alteration and replacement in acute respiratory distress syndrome.
Respiratory research 2001;2(6):353-64.
2001: Tobias Gessler; Thomas Schmehl; M M Hoeper; Frank Rose; Hossein A Ghofrani; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(1):14-9.
2001: Reinhold Schmidt; U Meier; M Yabut-Perez; Dieter Walmrath; Friedrich Grimminger; Werner Seeger; Andreas Günther
Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia.
American journal of respiratory and critical care medicine 2001;163(1):95-100.
2001: Katja Hattar; Ulf Sibelius; Annette Bickenbach; Elena Csernok; Werner Seeger; Friedrich Grimminger
Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis.
Journal of leukocyte biology 2001;69(1):89-97.
2001: Ulrich Grandel; Ulf Sibelius; J Schrickel; D Schmidt; Michael Buerke; Ludger Fink; Emmanoyil Bournelis; Martina Heep; Konstantin Mayer; Rainer M Bohle; Werner Seeger; Friedrich Grimminger
Biosynthesis of constitutive nitric oxide synthase-derived nitric oxide attenuates coronary vasoconstriction and myocardial depression in a model of septic heart failure induced by Staphylococcus aureus alpha-toxin.
Critical care medicine 2001;29(1):1-7.
2001: Ulrich A Maus; Susanne Herold; Heidrun Muth; Regina Maus; Leander Ermert; Monika Ermert; Norbert Weissmann; Simone Rosseau; Werner Seeger; Friedrich Grimminger; Jürgen Lohmeyer
Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14.
American journal of physiology. Lung cellular and molecular physiology 2001;280(1):L58-68.
2000: Richard Schulz; Horst Olschewski; Friedrich Grimminger; Werner Seeger
[Prevalence of stroke and transitory ischemic attacks in obstructive sleep apnea: a retrospective analyis so f 187 consecutive patients].
Pneumologie (Stuttgart, Germany) 2000;54(12):575-9.
2000: Richard Schulz; D Schmidt; A Blum; X Lopes-Ribeiro; C Lücke; Konstantin Mayer; Horst Olschewski; Werner Seeger; Friedrich Grimminger
Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy.
Thorax 2000;55(12):1046-51.
2000: Ulrich Grandel; Ludger Fink; A Blum; Martina Heep; Michael Buerke; H J Kraemer; Konstantin Mayer; Rainer M Bohle; Werner Seeger; Friedrich Grimminger; Ulf Sibelius
Endotoxin-induced myocardial tumor necrosis factor-alpha synthesis depresses contractility of isolated rat hearts: evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production.
Circulation 2000;102(22):2758-64.
2000: Norbert Weissmann; A Tadic; Jörg Hänze; Frank Rose; S Winterhalder; Matthias Nollen; Ralph Theo Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)?
American journal of physiology. Lung cellular and molecular physiology 2000;279(4):L683-90.
2000: Hartwig Schütte; Martin Witzenrath; Konstantin Mayer; Norbert Weissmann; A Schell; Simone Rosseau; Werner Seeger; Friedrich Grimminger
The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;279(3):L496-502.
2000: B Temmesfeld-Wollbrück; Konstantin Mayer; Friedrich Grimminger
Assessment of intestinal tissue oxygenation: the canary sings--but was does the twitter tell us?
Intensive care medicine 2000;26(8):1025-7.
2000: Richard Schulz; S Mahmoudi; Katja Hattar; Ulf Sibelius; Horst Olschewski; Konstantin Mayer; Werner Seeger; Friedrich Grimminger
Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):566-70.
2000: Norbert Weissmann; Robert Voswinckel; A Tadic; T Hardebusch; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Nitric oxide (NO)-dependent but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2000;23(2):222-7.
2000: Frank Rose; Ladislau Kiss; Friedrich Grimminger; Konstantin Mayer; Ulrich Grandel; Werner Seeger; E Bieniek; Ulf Sibelius
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid.
American journal of physiology. Lung cellular and molecular physiology 2000;279(1):L100-9.
2000: Simone Rosseau; P Hammerl; Ulrich A Maus; H D Walmrath; Hartwig Schütte; Friedrich Grimminger; Werner Seeger; Jürgen Lohmeyer
Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology 2000;279(1):L25-35.
2000: Frank Rose; K U Heuer; Ulf Sibelius; S Hombach-Klonisch; L Kiss; Werner Seeger; Friedrich Grimminger
Targeting lipopolysaccharides by the nontoxic polymyxin B nonapeptide sensitizes resistant Escherichia coli to the bactericidal effect of human neutrophils.
The Journal of infectious diseases 2000;182(1):191-9.
2000: Friedrich Grimminger; Frank Rose; H A Ghofrani; Ralph Theo Schermuly; N Weissmann; H Olschewski; Dieter Walmrath; W Seeger
[Inhalative strategies for improvement of pulmonary hemodynamics and gas exchange in sepsis and severe pulmonary hypertension].
Zeitschrift für Kardiologie 2000;89(6):477-84.
2000: Andreas Günther; P Mosavi; Clemens Ruppert; Sabine Heinemann; Bettina Temmesfeld; Hans-Georg Velcovsky; Harald Morr; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease.
Thrombosis and haemostasis 2000;83(6):853-60.
2000: Ladislau Kiss; Hartwig Schütte; Konstantin Mayer; Helmut Grimm; Winfried Padberg; Werner Seeger; Friedrich Grimminger
Synthesis of arachidonic acid-derived lipoxygenase and cytochrome P450 products in the intact human lung vasculature.
American journal of respiratory and critical care medicine 2000;161(6):1917-23.
2000: Rudolf A Jörres; Olaf Holz; W Zachgo; P Timm; S Koschyk; B Müller; Friedrich Grimminger; W Seeger; Frank Kelly; C Dunster; T Frischer; G Lubec; M Waschewski; A Niendorf; Helgo Magnussen
The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies.
American journal of respiratory and critical care medicine 2000;161(6):1855-61.
2000: Monika Ermert; M Merkle; R Mootz; Friedrich Grimminger; Werner Seeger; Leander Ermert
Endotoxin priming of the cyclooxygenase-2-thromboxane axis in isolated rat lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;278(6):L1195-203.
2000: Leander Ermert; Monika Ermert; M Merkle; M Goppelt-Struebe; Hans-Rainer Duncker; Friedrich Grimminger; Werner Seeger
Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: differential regulation in the various types of cells in the lung.
The American journal of pathology 2000;156(4):1275-87.
2000: Leander Ermert; Monika Ermert; Hans-Rainer Duncker; Friedrich Grimminger; Werner Seeger
In situ localization and regulation of thromboxane A(2) synthase in normal and LPS-primed lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;278(4):L744-53.
2000: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Ralph Theo Schermuly; Bettina Temmesfeld-Wollbrück; Friedrich Grimminger; W Seeger
[Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to pulmonary fibrosis].
Pneumologie (Stuttgart, Germany) 2000;54(3):133-42.
2000: Andreas Günther; P Mosavi; Sabine Heinemann; Clemens Ruppert; Heidrun Muth; Philipp Markart; Friedrich Grimminger; Dieter Walmrath; Bettina Temmesfeld-Wollbrück; Werner Seeger
Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):454-62.
2000: Friedrich Grimminger; Konstantin Mayer; Ladislau Kiss; Dieter Walmrath; Werner Seeger
PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L268-75.
2000: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; Christian Schudt; Hermann Tenor; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.
The Journal of pharmacology and experimental therapeutics 2000;292(2):512-20.
2000: Ulf Sibelius; Ulrich Grandel; Michael Buerke; D Mueller; Ladislau Kiss; H J Kraemer; Ruediger C Braun-Dullaeus; Werner Haberbosch; Werner Seeger; Friedrich Grimminger
Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation.
Circulation 2000;101(1):78-85.
2000: Ralph Theo Schermuly; Andreas Günther; Norbert Weissmann; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Dieter Walmrath
Differential impact of ultrasonically nebulized versus tracheal-instilled surfactant on ventilation-perfusion (VA/Q) mismatch in a model of acute lung injury.
American journal of respiratory and critical care medicine 2000;161(1):152-9.
2000: Simone Rosseau; J Selhorst; K Wiechmann; K Leissner; Ulrich A Maus; Konstantin Mayer; Friedrich Grimminger; Werner Seeger; Jürgen Lohmeyer
Monocyte migration through the alveolar epithelial barrier: adhesion molecule mechanisms and impact of chemokines.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):427-35.
1999: Andreas Günther; Philipp Markart; M Kalinowski; Clemens Ruppert; Friedrich Grimminger; Werner Seeger
Cleavage of surfactant-incorporating fibrin by different fibrinolytic agents. Kinetics of lysis and rescue of surface activity.
American journal of respiratory cell and molecular biology 1999;21(6):738-45.
1999: Ralph Theo Schermuly; Hossein A Ghofrani; Beate Enke; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Christian Schudt; Dieter Walmrath
Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1500-6.
1999: Simone Rosseau; P Hammerl; Ulrich A Maus; Andreas Günther; Werner Seeger; Friedrich Grimminger; Jürgen Lohmeyer
Surfactant protein A down-regulates proinflammatory cytokine production evoked by Candida albicans in human alveolar macrophages and monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4495-502.
1999: Gerd Hermle; Hartwig Schütte; Dieter Walmrath; Klaus K Geiger; Werner Seeger; Friedrich Grimminger
Ventilation-perfusion mismatch after lung ischemia-reperfusion. Protective effect of nitric oxide.
American journal of respiratory and critical care medicine 1999;160(4):1179-87.
1999: Andreas Günther; Reinhold Schmidt; F Nix; M Yabut-Perez; C Guth; Simone Rosseau; C Siebert; Friedrich Grimminger; Harald Morr; Hans-Georg Velcovsky; Werner Seeger
Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(3):565-73.
1999: Frank Rose; K Zwick; Hossein A Ghofrani; Ulf Sibelius; Werner Seeger; Dieter Walmrath; Friedrich Grimminger
Prostacyclin enhances stretch-induced surfactant secretion in alveolar epithelial type II cells.
American journal of respiratory and critical care medicine 1999;160(3):846-51.
1999: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Ralph Theo Schermuly; B Temmesfeld-Wollbruck; Friedrich Grimminger; Werner Seeger
Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.
American journal of respiratory and critical care medicine 1999;160(2):600-7.
1999: Friedrich Grimminger; Horst Olschewski; Werner Seeger
[Vasotropic therapy and artificial respiration for pulmonary hypertension].
Der Internist 1999;40(7):747-55.
1999: Horst Olschewski; Werner Seeger; Friedrich Grimminger
[Physiology and physiopathology of the pulmonary circulation].
Der Internist 1999;40(7):696-709.
1999: Jürgen Lohmeyer; J Friedrich; Friedrich Grimminger; Ulrich A Maus; R Tenter; Harald Morr; Hans-Georg Velcovsky; Werner Seeger; Simone Rosseau
Expression of mucosa-related integrin alphaEbeta7 on alveolar T cells in interstitial lung diseases.
Clinical and experimental immunology 1999;116(2):340-6.
1999: Ruediger C Braun-Dullaeus; M Feussner; G Walker; H Hopmann; H J Kraemer; Friedrich Grimminger; Harald Tillmanns; Werner Haberbosch
Cyclosporine-induced coronary artery constriction--dissociation between thromboxane release and coronary vasospasm.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1999;18(4):328-35.
1999: Ulf Sibelius; E C Schulz; Frank Rose; Katja Hattar; T Jacobs; S Weiss; Trinad Chakraborty; Werner Seeger; Friedrich Grimminger
Role of Listeria monocytogenes exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C in activation of human neutrophils.
Infection and immunity 1999;67(3):1125-30.
1999: Ulrich A Maus; Simone Rosseau; N Mandrakas; Reimar Schlingensiepen; Regina Maus; Heidrun Muth; Friedrich Grimminger; Werner Seeger; Jürgen Lohmeyer
Cationic lipids employed for antisense oligodeoxynucleotide transport may inhibit vascular cell adhesion molecule-1 expression in human endothelial cells: a word of caution.
Antisense & nucleic acid drug development 1999;9(1):71-80.
1999: Norbert Weissmann; Robert Voswinckel; T Hardebusch; Simone Rosseau; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction.
The American journal of physiology 1999;276(1 Pt 1):L90-5.
1999: Frank Rose; C Kürth-Landwehr; Ulf Sibelius; K H Reuner; K Aktories; W Seeger; Friedrich Grimminger
Role of actin depolymerization in the surfactant secretory response of alveolar epithelial type II cells.
American journal of respiratory and critical care medicine 1999;159(1):206-12.
1998: Helmut Grimm; Friedrich Grimminger; Stephan Korom; Werner Seeger
Use of fish oil to prevent graft rejection.
The Proceedings of the Nutrition Society 1998;57(4):577-85.
1998: Ludger Fink; W Seeger; Leander Ermert; Jörg Hänze; U Stahl; Friedrich Grimminger; W Kummer; R M Bohle
Real-time quantitative RT-PCR after laser-assisted cell picking.
Nature medicine 1998;4(11):1329-33.
1998: Norbert Weissmann; Werner Seeger; Jörg Conzen; Ladislau Kiss; Friedrich Grimminger
Effects of arachidonic acid metabolism on hypoxic vasoconstriction in rabbit lungs.
European journal of pharmacology 1998;356(2-3):231-7.
1998: Leander Ermert; Monika Ermert; André Althoff; M Merkle; Friedrich Grimminger; Werner Seeger
Vasoregulatory prostanoid generation proceeds via cyclooxygenase-2 in noninflamed rat lungs.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1309-14.
1998: Ladislau Kiss; E Bieniek; Norbert Weissmann; H Schutte; Ulf Sibelius; Andreas Gunther; J Bier; Konstantin Mayer; K Henneking; Winfried Padberg; Helmut Grimm; Werner Seeger; Friedrich Grimminger
Simultaneous analysis of 4- and 5-series lipoxygenase and cytochrome P450 products from different biological sources by reversed-phase high-performance liquid chromatographic technique.
Analytical biochemistry 1998;261(1):16-28.
1998: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Bettina Temmesfeld-Wollbrück; Friedrich Grimminger; Werner Seeger
Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost.
Intensive care medicine 1998;24(6):631-4.
1998: Norbert Weissmann; Friedrich Grimminger; Robert Voswinckel; Jörg Conzen; Werner Seeger
Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs.
The American journal of physiology 1998;274(5 Pt 1):L721-7.
1998: Bettina Temmesfeld-Wollbrück; A Szalay; Konstantin Mayer; Horst Olschewski; Werner Seeger; Friedrich Grimminger
Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine.
American journal of respiratory and critical care medicine 1998;157(5 Pt 1):1586-92.
1998: Peter Mayser; U Mrowietz; P Arenberger; P Bartak; J Buchvald; E Christophers; S Jablonska; W Salmhofer; Wolf-Bernhard Schill; Hans-Joachim Krämer; E Schlotzer; Konstantin Mayer; Werner Seeger; Friedrich Grimminger
Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial.
Journal of the American Academy of Dermatology 1998;38(4):539-47.
1998: Leander Ermert; Monika Ermert; M Goppelt-Struebe; Dieter Walmrath; Friedrich Grimminger; W Steudel; Hossein A Ghofrani; C Homberger; Hans-Rainer Duncker; Werner Seeger
Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs.
American journal of respiratory cell and molecular biology 1998;18(4):479-88.
1998: Konstantin Mayer; Werner Seeger; Friedrich Grimminger
Clinical use of lipids to control inflammatory disease.
Current opinion in clinical nutrition and metabolic care 1998;1(2):179-84.
1998: Ulf Sibelius; Katja Hattar; A Schenkel; Thomas Noll; Elena Csernok; W L Gross; Werner-Johannes Mayet; Hans Michael Piper; Werner Seeger; Friedrich Grimminger
Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response.
The Journal of experimental medicine 1998;187(4):497-503.
1998: Hartwig Schütte; Konstantin Mayer; Tobias Gessler; M Rühl; J Schlaudraff; H Burger; Werner Seeger; Friedrich Grimminger
Nitric oxide biosynthesis in an exotoxin-induced septic lung model: role of cNOS and impact on pulmonary hemodynamics.
American journal of respiratory and critical care medicine 1998;157(2):498-504.
1998: Horst Olschewski; Dieter Walmrath; Ralph Theo Schermuly; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
[Prostacyclin and iloprost in aerosol form in severe pulmonary hypertension].
Pneumologie (Stuttgart, Germany) 1998;52(1):3-7.
1998: Hartwig Schütte; Gerd Hermle; Werner Seeger; Friedrich Grimminger
Vascular distension and continued ventilation are protective in lung ischemia/reperfusion.
American journal of respiratory and critical care medicine 1998;157(1):171-7.
1997: Hartwig Schütte; Simone Rosseau; R Czymek; Leander Ermert; Dieter Walmrath; Hans-Joachim Krämer; Werner Seeger; Friedrich Grimminger
Synergism between endotoxin priming and exotoxin challenge in provoking severe vascular leakage in rabbit lungs.
American journal of respiratory and critical care medicine 1997;156(3 Pt 1):819-24.
1997: Friedrich Grimminger; Frank Rose; Ulf Sibelius; M Meinhardt; Bernd Pötzsch; R Spriestersbach; Sucharit Bhakdi; Norbert Suttorp; Werner Seeger
Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1909-16.
1997: Ralph Theo Schermuly; Thomas Schmehl; Andreas Günther; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury. Impact on gas exchange.
American journal of respiratory and critical care medicine 1997;156(2 Pt 1):445-53.
1997: Hartwig Schütte; Friedrich Grimminger; J Otterbein; R Spriestersbach; Konstantin Mayer; Dieter Walmrath; Werner Seeger
Efficiency of aerosolized nitric oxide donor drugs to achieve sustained pulmonary vasodilation.
The Journal of pharmacology and experimental therapeutics 1997;282(2):985-94.
1997: Friedrich Grimminger; Konstantin Mayer; Werner Seeger
[Is there a reliable immunotherapy in infection?].
Der Internist 1997;38(6):541-52.
1997: Dieter Walmrath; Horst Olschewski; Friedrich Grimminger; Werner Seeger
[NO and alternative inhalational therapy approaches in pulmonary hypertension].
Der Internist 1997;38(5):453-60.
1997: Dieter Walmrath; Ralph Theo Schermuly; J Pilch; Friedrich Grimminger; Werner Seeger
Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(5):1084-92.
1997: Bettina Temmesfeld-Wollbrück; A Szalay; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Advantage of buffered solutions or automated capnometry in air-filled balloons for use in gastric tonometry.
Intensive care medicine 1997;23(4):423-7.
1997: Friedrich Grimminger; Konstantin Mayer; Ladislau Kiss; H Wahn; Dieter Walmrath; Werner Seeger
Synthesis of 4- and 5-series leukotrienes in the lung microvasculature challenged with Escherichia coli hemolysin: critical dependence on exogenous free fatty acid supply.
American journal of respiratory cell and molecular biology 1997;16(3):317-24.
1997: Leander Ermert; Hans-Rainer Duncker; Hans Brückner; Friedrich Grimminger; T Hansen; R Rössig; K Aktories; Werner Seeger
Ultrastructural changes of lung capillary endothelium in response to botulinum C2 toxin.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;82(2):382-8.
1997: Friedrich Grimminger; H Wahn; Konstantin Mayer; Ladislau Kiss; Dieter Walmrath; Werner Seeger
Impact of arachidonic versus eicosapentaenoic acid on exotonin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation.
American journal of respiratory and critical care medicine 1997;155(2):513-9.
1997: D Nowak; Rudolf A Jörres; L Martinez-Müller; Friedrich Grimminger; W Seeger; F Koops; Helgo Magnussen
Effect of 3 hours of passive smoke exposure in the evening on inflammatory markers in bronchoalveolar and nasal lavage fluid in subjects with mild asthma.
International archives of occupational and environmental health 1997;70(2):85-93.
1996: Ulf Sibelius; Trinad Chakraborty; B Krögel; J Wolf; Frank Rose; Reinhold Schmidt; Jürgen Wehland; Werner Seeger; Friedrich Grimminger
The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):4055-60.
1996: Hans-Joachim Krämer; J Stevens; Friedrich Grimminger; Werner Seeger
Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation.
Biochemical pharmacology 1996;52(8):1211-7.
1996: Friedrich Grimminger; Katja Hattar; C Papavassilis; B Temmesfeld; E Csernok; W L Gross; Werner Seeger; Ulf Sibelius
Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation.
The Journal of experimental medicine 1996;184(4):1567-72.
1996: Hartwig Schütte; Jürgen Lohmeyer; Simone Rosseau; S Ziegler; C Siebert; H Kielisch; H Pralle; Friedrich Grimminger; Harald Morr; Werner Seeger
Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(9):1858-67.
1996: Dieter Walmrath; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
Synergism of alveolar endotoxin "priming" and intravascular exotoxin challenge in lung injury.
American journal of respiratory and critical care medicine 1996;154(2 Pt 1):460-8.
1996: Dieter Walmrath; Andreas Günther; Hossein A Ghofrani; Ralph Theo Schermuly; T Schneider; Friedrich Grimminger; Werner Seeger
Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis.
American journal of respiratory and critical care medicine 1996;154(1):57-62.
1996: Konrad Reinhart; C Wiegand-Löhnert; Friedrich Grimminger; M Kaul; S Withington; D Treacher; J Eckart; S Willatts; C Bouza; D Krausch; F Stockenhuber; J Eiselstein; L Daum; J Kempeni
Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study.
Critical care medicine 1996;24(5):733-42.
1996: Horst Olschewski; Dieter Walmrath; Ralph Theo Schermuly; A Ghofrani; Friedrich Grimminger; Werner Seeger
Aerosolized prostacyclin and iloprost in severe pulmonary hypertension.
Annals of internal medicine 1996;124(9):820-4.
1996: Hans-Peter Hammes; A Weiss; D Führer; Hans-Joachim Krämer; C Papavassilis; Friedrich Grimminger
Acceleration of experimental diabetic retinopathy in the rat by omega-3 fatty acids.
Diabetologia 1996;39(3):251-5.
1996: Dieter Walmrath; T Schneider; Ralph Theo Schermuly; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 1996;153(3):991-6.
1996: Ulf Sibelius; Frank Rose; Trinad Chakraborty; Ayub Darji; Jürgen Wehland; S Weiss; Werner Seeger; Friedrich Grimminger
Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.
Infection and immunity 1996;64(2):674-6.
1996: Friedrich Grimminger; Helmut Grimm; D Führer; C Papavassilis; G Lindemann; C Blecher; Konstantin Mayer; F Tabesch; Hans-Joachim Krämer; J Stevens; Werner Seeger
Omega-3 lipid infusion in a heart allotransplant model. Shift in fatty acid and lipid mediator profiles and prolongation of transplant survival.
Circulation 1996;93(2):365-71.
1996: Sucharit Bhakdi; Iwan Walev; D Jonas; Michael Palmer; U Weller; Norbert Suttorp; Friedrich Grimminger; W Seeger
Pathogenesis of sepsis syndrome: possible relevance of pore-forming bacterial toxins.
Current topics in microbiology and immunology 1996;216():101-18.
1996: Hossein A Ghofrani; Simone Rosseau; Dieter Walmrath; W Kaddus; A Kramer; Friedrich Grimminger; Jürgen Lohmeyer; Werner Seeger
Compartmentalized lung cytokine release in response to intravascular and alveolar endotoxin challenge.
The American journal of physiology 1996;270(1 Pt 1):L62-8.
1996: Andreas Günther; C Siebert; Reinhold Schmidt; S Ziegler; Friedrich Grimminger; M Yabut; B Temmesfeld; Dieter Walmrath; Harald Morr; Werner Seeger
Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema.
American journal of respiratory and critical care medicine 1996;153(1):176-84.
1995: Werner Seeger; Dieter Walmrath; Friedrich Grimminger
[New supportive therapy measures in acute lung failure].
Der Internist 1995;36(12):1139-49.
1995: Werner Seeger; Dieter Walmrath; Friedrich Grimminger
[ARDS. Intensive therapy of acute lung failure].
Der Internist 1995;36(8):785-801.
1995: Werner Seeger; T Hansen; R Rössig; T Schmehl; Hartwig Schütte; Hans-Joachim Krämer; Dieter Walmrath; Norbert Weissmann; Friedrich Grimminger; Norbert Suttorp
Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability--effect of adenylate cyclase stimulation and phosphodiesterase inhibition.
Microvascular research 1995;50(1):1-17.
1995: Friedrich Grimminger; H Wahn; H J Kramer; J Stevens; Konstantin Mayer; Dieter Walmrath; Werner Seeger
Differential influence of arachidonic vs. eicosapentaenoic acid on experimental pulmonary hypertension.
The American journal of physiology 1995;268(6 Pt 2):H2252-9.
1995: Leander Ermert; Hans Brückner; Dieter Walmrath; Friedrich Grimminger; Klaus Aktories; Norbert Suttorp; Hans-Rainer Duncker; Werner Seeger
Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs.
The American journal of physiology 1995;268(5 Pt 1):L753-61.
1995: Friedrich Grimminger; Norbert Weissmann; R Spriestersbach; E Becker; Simone Rosseau; Werner Seeger
Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs.
The American journal of physiology 1995;268(5 Pt 1):L747-52.
1995: Norbert Weissmann; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Hypoxic vasoconstriction in buffer-perfused rabbit lungs.
Respiration physiology 1995;100(2):159-69.
1995: Helmut Grimm; Annika Tibell; B Norrlind; J Schott; R M Bohle; C Papavassilis; D Führer; Konstantin Mayer; Friedrich Grimminger
[Immunosuppressive effect of parenteral fat emulsions in defined immunostimulation].
Infusionstherapie und Transfusionsmedizin 1995;22(2):110-6.
1995: Friedrich Grimminger; R Spriestersbach; Norbert Weissmann; Dieter Walmrath; Werner Seeger
Nitric oxide generation and hypoxic vasoconstriction in buffer-perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(4):1509-15.
1995: R Spriestersbach; Friedrich Grimminger; Norbert Weissmann; Dieter Walmrath; Werner Seeger
On-line measurement of nitric oxide generation in buffer-perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(4):1502-8.
1995: Dieter Walmrath; T Schneider; J Pilch; Ralph Theo Schermuly; Friedrich Grimminger; Werner Seeger
Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis.
American journal of respiratory and critical care medicine 1995;151(3 Pt 1):724-30.
1995: Rudolf A Jörres; D Nowak; Friedrich Grimminger; W Seeger; M Oldigs; Helgo Magnussen
The effect of 1 ppm nitrogen dioxide on bronchoalveolar lavage cells and inflammatory mediators in normal and asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(3):416-24.
1995: Friedrich Grimminger; Peter Mayser
Lipid mediators, free fatty acids and psoriasis.
Prostaglandins, leukotrienes, and essential fatty acids 1995;52(1):1-15.
1995: Bettina Temmesfeld-Wollbrück; Dieter Walmrath; Friedrich Grimminger; Werner Seeger
Prevention and therapy of the adult respiratory distress syndrome.
Lung 1995;173(3):139-64.
1994: Dieter Walmrath; Hossein A Ghofrani; Simone Rosseau; Hartwig Schütte; A Cramer; W Kaddus; Friedrich Grimminger; Sucharit Bhakdi; Werner Seeger
Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin.
The Journal of experimental medicine 1994;180(4):1437-43.
1994: Sucharit Bhakdi; Friedrich Grimminger; Norbert Suttorp; D Walmrath; W Seeger
Proteinaceous bacterial toxins and pathogenesis of sepsis syndrome and septic shock: the unknown connection.
Medical microbiology and immunology 1994;183(3):119-44.
1994: Dieter Walmrath; J Pilch; M Scharmann; Friedrich Grimminger; Werner Seeger
Severe VA/Q mismatch in perfused lungs evoked by sequential challenge with endotoxin and E. coli hemolysin.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(3):1020-30.
1994: Werner Seeger; Dieter Walmrath; Friedrich Grimminger; Simone Rosseau; Hartwig Schütte; Hans-Joachim Krämer; Leander Ermert; Ladislau Kiss
Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs.
Methods in enzymology 1994;233():549-84.
1993: Friedrich Grimminger; D Führer; C Papavassilis; E Schlotzer; Konstantin Mayer; K U Heuer; Ladislau Kiss; Dieter Walmrath; S Piberhofer; F Lübbecke
Influence of intravenous n-3 lipid supplementation on fatty acid profiles and lipid mediator generation in a patient with severe ulcerative colitis.
European journal of clinical investigation 1993;23(11):706-15.
1993: Dieter Walmrath; M Griebner; B Kolb; Friedrich Grimminger; C Galanos; U Schade; Werner Seeger
Endotoxin primes perfused rabbit lungs for enhanced vasoconstrictor response to staphylococcal alpha-toxin.
The American review of respiratory disease 1993;148(5):1179-86.
1993: Dieter Walmrath; T Schneider; J Pilch; Friedrich Grimminger; Werner Seeger
Aerosolised prostacyclin in adult respiratory distress syndrome.
Lancet 1993;342(8877):961-2.
1993: Friedrich Grimminger; Konstantin Mayer; Hans-Joachim Krämer; J Stevens; Dieter Walmrath; Werner Seeger
Differential vasoconstrictor potencies of free fatty acids in the lung vasculature: 2-versus 3-series prostanoid generation.
The Journal of pharmacology and experimental therapeutics 1993;267(1):259-65.
1993: Friedrich Grimminger; Peter Mayser; C Papavassilis; M Thomas; E Schlotzer; K U Heuer; D Führer; Klaus-Dieter Hinsch; Dieter Walmrath; W B Schill
A double-blind, randomized, placebo-controlled trial of n-3 fatty acid based lipid infusion in acute, extended guttate psoriasis. Rapid improvement of clinical manifestations and changes in neutrophil leukotriene profile.
The Clinical investigator 1993;71(8):634-43.
1993: Norbert Suttorp; M Fuhrmann; S Tannert-Otto; Friedrich Grimminger; S Bhadki
Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells.
The Journal of experimental medicine 1993;178(1):337-41.
1993: Dieter Walmrath; M Scharmann; R König; J Pilch; Friedrich Grimminger; Werner Seeger
Staphylococcal alpha-toxin induced ventilation-perfusion mismatch in isolated blood-free perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(4):1972-80.
1993: Werner Seeger; Andreas Günther; H D Walmrath; Friedrich Grimminger; H G Lasch
Alveolar surfactant and adult respiratory distress syndrome. Pathogenetic role and therapeutic prospects.
The Clinical investigator 1993;71(3):177-90.
1993: D Nowak; Friedrich Grimminger; Rudolf A Jörres; M Oldigs; Klaus F Rabe; W Seeger; Helgo Magnussen
Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(3):405-12.
1992: Werner Seeger; Friedrich Grimminger; Dieter Walmrath
[ARDS: possible role of bacterial exotoxin].
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 1992;27(5):310-4.
1992: Friedrich Grimminger; U Dürr; Werner Seeger
Ligand-operated synthesis of 4-series and 5-series leukotrienes in human neutrophils: critical dependence on exogenous free fatty acid supply.
Molecular pharmacology 1992;41(4):757-66.
1992: Leander Ermert; S Rousseau; Hartwig Schütte; R G Birkemeyer; Friedrich Grimminger; Sucharit Bhakdi; Hans-Rainer Duncker; Werner Seeger
Induction of severe vascular leakage by low doses of Escherichia coli hemolysin in perfused rabbit lungs.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):362-9.
1992: Friedrich Grimminger; I von Kürten; Dieter Walmrath; Werner Seeger
Type II alveolar epithelial eicosanoid metabolism: predominance of cyclooxygenase pathways and transcellular lipoxygenase metabolism in co-culture with neutrophils.
American journal of respiratory cell and molecular biology 1992;6(1):9-16.
1992: Dieter Walmrath; R König; C Ernst; Hans Brückner; Friedrich Grimminger; Werner Seeger
Ventilation-perfusion relationships in isolated blood-free perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(1):374-82.
1991: Dieter Walmrath; U Schneider; B Kreusler; Friedrich Grimminger; M Ennis; Werner Seeger
Intravascular anti-IgE challenge in perfused lungs: mediator release and vascular pressor response.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(6):2499-506.
1991: Friedrich Grimminger; Ulf Sibelius; Sucharit Bhakdi; Norbert Suttorp; Werner Seeger
Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils.
The Journal of clinical investigation 1991;88(5):1531-9.
1991: Friedrich Grimminger; Ulf Sibelius; Klaus Aktories; Ingo Just; Werner Seeger
Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction.
The Journal of biological chemistry 1991;266(29):19276-82.
1991: Hartwig Schütte; Simone Rosseau; Dieter Walmrath; Friedrich Grimminger; C Ernst; Werner Seeger
Neutrophil passage through isolated perfused rabbit lungs.
The American journal of physiology 1991;261(4 Pt 2):H1317-23.
1991: Friedrich Grimminger; Ulf Sibelius; Klaus Aktories; Norbert Suttorp; Werner Seeger
Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils.
Molecular pharmacology 1991;40(4):563-71.
1991: Friedrich Grimminger; C Scholz; Sucharit Bhakdi; Werner Seeger
Subhemolytic doses of Escherichia coli hemolysin evoke large quantities of lipoxygenase products in human neutrophils.
The Journal of biological chemistry 1991;266(22):14262-9.
1991: Friedrich Grimminger; Ulf Sibelius; Werner Seeger
Amplification of LTB4 generation in AM-PMN cocultures: transcellular 5-lipoxygenase metabolism.
The American journal of physiology 1991;261(2 Pt 1):L195-203.
1991: Norbert Suttorp; M Polley; J Seybold; Hans-Joachim Schnittler; Werner Seeger; Friedrich Grimminger; Klaus Aktories
Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro.
The Journal of clinical investigation 1991;87(5):1575-84.
1991: Werner Seeger; R Obernitz; M Thomas; Dieter Walmrath; N Suttorn; I B Holland; Friedrich Grimminger; B Eberspächer; F Hugo; Sucharit Bhakdi
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
The American review of respiratory disease 1991;143(4 Pt 1):797-805.
1991: Friedrich Grimminger; B Kreusler; U Schneider; E von Witzleben; Dieter Walmrath; Juergen Neppert; Werner Seeger
Human leukoagglutinating antibody evokes cooperative leukotriene synthesis in pulmonary microvasculature. Model of transfusion-related acute lung injury.
Circulation research 1991;68(2):503-12.
1991: Friedrich Grimminger; Dieter Walmrath; H Walter; F Lutz; Werner Seeger
Induction of vascular injury by Pseudomonas aeruginosa cytotoxin in rabbit lungs is associated with the generation of different leukotrienes and hydroxyeicosatetraenoic acids.
The Journal of infectious diseases 1991;163(2):362-70.
1991: W Seeger; Friedrich Grimminger
Leukotrienes and ARDS.
Intensive care medicine 1991;17(1):65-6.
1991: Werner Seeger; Friedrich Grimminger; M Barden; G Becker; Jürgen Lohmeyer; D Heinrich; H G Lasch
Omega-oxidized leukotriene B4 detected in the broncho-alveolar lavage fluid of patients with non-cardiogenic pulmonary edema, but not in those with cardiogenic edema.
Intensive care medicine 1991;17(1):1-6.
1990: Werner Seeger; U Schneider; B Kreusler; E von Witzleben; Dieter Walmrath; Friedrich Grimminger; Juergen Neppert
Reproduction of transfusion-related acute lung injury in an ex vivo lung model.
Blood 1990;76(7):1438-44.
1990: Friedrich Grimminger; M Thomas; R Obernitz; Dieter Walmrath; Sucharit Bhakdi; Werner Seeger
Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature.
The Journal of experimental medicine 1990;172(4):1115-25.
1990: Friedrich Grimminger; Dieter Walmrath; R G Birkemeyer; Sucharit Bhakdi; Werner Seeger
Leukotriene and hydroxyeicosatetraenoic acid generation elicited by low doses of Escherichia coli hemolysin in rabbit lungs.
Infection and immunity 1990;58(8):2659-63.
1990: Friedrich Grimminger; B Kreusler; U Schneider; G Becker; Werner Seeger
Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1866-72.
1990: W Seeger; Friedrich Grimminger
[The role of arachidonic acid metabolites in the pathogenesis of bronchial asthma].
Verhandlungen der Deutschen Gesellschaft für Innere Medizin 1990;96():685-93.
1988: Friedrich Grimminger; M Menger; G Becker; Werner Seeger
Potentiation of leukotriene production following sequestration of neutrophils in isolated lungs: indirect evidence for intercellular leukotriene A4 transfer.
Blood 1988;72(5):1687-92.
1988: Friedrich Grimminger; G Becker; Werner Seeger
High yield enzymatic conversion of intravascular leukotriene A4 in blood-free perfused lungs.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(7):2431-6.
1987: Werner Seeger; M Menger; Dieter Walmrath; G Becker; Friedrich Grimminger; H Neuhof
Arachidonic acid lipoxygenase pathways and increased vascular permeability in isolated rabbit lungs.
The American review of respiratory disease 1987;136(4):964-72.