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Friedrich Grimminger

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Ghofrani Hossein-Ardeschir; Voswinckel Robert; Gall Henning; Schermuly Ralph; Weissmann Norbert; Seeger Werner; Grimminger Friedrich
Riociguat for pulmonary hypertension.
Dahal Bhola Kumar; Cornitescu Teodora; Tretyn Aleksandra; Pullamsetti Soni Savai; Kosanovic Djuro; Dumitrascu Rio; Ghofrani Hossein Ardeschir; Weissmann Norbert; Voswinckel Robert; Banat Gamal-Andre; Seeger Werner; Grimminger Friedrich; Schermuly Ralph Theo
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.
Savai Rajkumar; Pullamsetti Soni Savai; Banat Gamal-Andre; Weissmann Norbert; Ghofrani Hossein Ardeschir; Grimminger Friedrich; Schermuly Ralph Theo
Targeting cancer with phosphodiesterase inhibitors.

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2010: Ghofrani Hossein-Ardeschir; Voswinckel Robert; Gall Henning; Schermuly Ralph; Weissmann Norbert; Seeger Werner; Grimminger Friedrich
Riociguat for pulmonary hypertension.
Future cardiology 2010;6(2):155-66.
2010: Dahal Bhola Kumar; Cornitescu Teodora; Tretyn Aleksandra; Pullamsetti Soni Savai; Kosanovic Djuro; Dumitrascu Rio; Ghofrani Hossein Ardeschir; Weissmann Norbert; Voswinckel Robert; Banat Gamal-Andre; Seeger Werner; Grimminger Friedrich; Schermuly Ralph Theo
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2010;181(2):158-67.
2010: Savai Rajkumar; Pullamsetti Soni Savai; Banat Gamal-Andre; Weissmann Norbert; Ghofrani Hossein Ardeschir; Grimminger Friedrich; Schermuly Ralph Theo
Targeting cancer with phosphodiesterase inhibitors.
Expert opinion on investigational drugs 2010;19(1):117-31.
2010: Grimminger Friedrich; Schermuly Ralph Theo
PDGF Receptor and its Antagonists: Role in Treatment of PAH.
Advances in experimental medicine and biology 2010;661():435-46.
2010: Fuchs B; Dietrich A; Gudermann T; Kalwa H; Grimminger F; Weissmann N
The role of classical transient receptor potential channels in the regulation of hypoxic pulmonary vasoconstriction.
Advances in experimental medicine and biology 2010;661():187-200.
2009: Ketabchi Farzaneh; Egemnazarov Bakytbek; Schermuly Ralph T; Ghofrani Hossein A; Seeger Werner; Grimminger Friedrich; Shid-Moosavi Mostafa; Dehghani Gholam A; Weissmann Norbert; Sommer Natascha
Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction.
American journal of physiology. Lung cellular and molecular physiology 2009;297(5):L977-83.
2009: Kolosionek Ewa; Savai Rajkumar; Ghofrani Hossein Ardeschir; Weissmann Norbert; Guenther Andreas; Grimminger Friedrich; Seeger Werner; Banat Gamal Andre; Schermuly Ralph Theo; Pullamsetti Soni Savai
Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.
Molecular biology of the cell 2009;20(22):4751-65.
2009: Weissmann Norbert; Hackemack Sascha; Dahal Bhola Kumar; Pullamsetti Soni Savai; Savai Rajkumar; Mittal Manish; Fuchs Beate; Medebach Thomas; Dumitrascu Rio; Eickels Martin van; Ghofrani Hossein Ardeschir; Seeger Werner; Grimminger Friedrich; Schermuly Ralph Theo
The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.
American journal of physiology. Lung cellular and molecular physiology 2009;297(4):L658-65.
2009: Grandel Ulrich; Heygster Diana; Sibelius Ulf; Fink Ludger; Sigel Stefanie; Seeger Werner; Grimminger Friedrich; Hattar Katja
Amplification of lipopolysaccharide-induced cytokine synthesis in non-small cell lung cancer/neutrophil cocultures.
Molecular cancer research : MCR 2009;7(10):1729-35.
2009: Voswinckel R; Reichenberger F; Gall H; Seeger W; Grimminger F; Ghofrani H A
[Therapy of pulmonary arterial hypertension]
Der Internist 2009;50(9):1101-2, 1104-9.
2009: Cakarova Lidija; Marsh Leigh M; Wilhelm Jochen; Mayer Konstantin; Grimminger Friedrich; Seeger Werner; Lohmeyer Juergen; Herold Susanne
Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.
American journal of respiratory and critical care medicine 2009;180(6):521-32.
2009: Markart P; Ghofrani H A; Grimminger F; Günther A
[Pulmonary hypertension in COPD and interstitial lung diseases]
Deutsche medizinische Wochenschrift (1946) 2009;134 Suppl 5():S164-6.
2009: Roth Markus; Rupp Markus; Hofmann Simone; Mittal Manish; Fuchs Beate; Sommer Natascha; Parajuli Nirmal; Quanz Karin; Schubert Dominic; Dony Eva; Schermuly Ralph Theo; Ghofrani Hossein Ardeschir; Sausbier Ulrike; Rutschmann Katrin; Wilhelm Sarah; Seeger Werner; Ruth Peter; Grimminger Friedrich; Sausbier Matthias; Weissmann Norbert
Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.
American journal of respiratory and critical care medicine 2009;180(4):353-64.
2009: Ghofrani Hossein A; Barst Robyn J; Benza Raymond L; Champion Hunter C; Fagan Karen A; Grimminger Friedrich; Humbert Marc; Simonneau Gérald; Stewart Duncan J; Ventura Carlo; Rubin Lewis J
Future perspectives for the treatment of pulmonary arterial hypertension.
Journal of the American College of Cardiology 2009;54(1 Suppl):S108-17.
2009: Hassoun Paul M; Mouthon Luc; Barberà Joan A; Eddahibi Saadia; Flores Sonia C; Grimminger Friedrich; Jones Peter Lloyd; Maitland Michael L; Michelakis Evangelos D; Morrell Nicholas W; Newman John H; Rabinovitch Marlene; Schermuly Ralph; Stenmark Kurt R; Voelkel Norbert F; Yuan Jason X-J; Humbert Marc
Inflammation, growth factors, and pulmonary vascular remodeling.
Journal of the American College of Cardiology 2009;54(1 Suppl):S10-9.
2009: Grandel Ulrich; Bennemann Ulrich; Buerke Michael; Hattar Katja; Seeger Werner; Grimminger Friedrich; Sibelius Ulf
Staphylococcus aureus alpha-toxin and Escherichia coli hemolysin impair cardiac regional perfusion and contractile function by activating myocardial eicosanoid metabolism in isolated rat hearts.
Critical care medicine 2009;37(6):2025-32.
2009: Laumanns Isabel P; Fink Ludger; Wilhelm Jochen; Wolff Jens-C; Mitnacht-Kraus Rita; Graef-Hoechst Sabine; Stein Maria M; Bohle Rainer M; Klepetko Walter; Hoda Mir A R; Schermuly Ralph T; Grimminger Friedrich; Seeger Werner; Voswinckel Robert
The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension.
American journal of respiratory cell and molecular biology 2009;40(6):683-91.
2009: Yu Ying; Keller Steve H; Remillard Carmelle V; Safrina Olga; Nicholson Ann; Zhang Shenyuan L; Jiang Weihua; Vangala Nivruthi; Landsberg Judd W; Wang Jian-Ying; Thistlethwaite Patricia A; Channick Richard N; Robbins Ivan M; Loyd James E; Ghofrani Hossein A; Grimminger Friedrich; Schermuly Ralph T; Cahalan Michael D; Rubin Lewis J; Yuan Jason X-J
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.
Circulation 2009;119(17):2313-22.
2009: Woyda K; Koebrich S; Reiss I; Rudloff S; Pullamsetti S S; Rühlmann A; Weissmann N; Ghofrani H A; Günther A; Seeger W; Grimminger F; Morty R E; Schermuly R T
Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(4):861-70.
2009: Grimminger F; Weimann G; Frey R; Voswinckel R; Thamm M; Bölkow D; Weissmann N; Mück W; Unger S; Wensing G; Schermuly R T; Ghofrani H A
First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(4):785-92.
2009: Egemnazarov Bakytbek; Sydykov Akylbek; Schermuly Ralph T; Weissmann Norbert; Stasch Johannes-Peter; Sarybaev Akpai S; Seeger Werner; Grimminger Friedrich; Ghofrani Hossein A
Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology 2009;296(3):L462-9.
2009: Kamlah F; Eul B G; Li S; Lang N; Marsh L M; Seeger W; Grimminger F; Rose F; Hänze J
Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model.
Cancer gene therapy 2009;16(3):195-205.
2009: Voswinckel Robert; Reichenberger Frank; Gall Henning; Schmehl Thomas; Gessler Tobias; Schermuly Ralph Theo; Grimminger Friedrich; Rubin Lewis J; Seeger Werner; Ghofrani Hossein A; Olschewski Horst
Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2009;22(1):50-6.
2008: Sommer N; Dietrich A; Schermuly R T; Ghofrani H A; Gudermann T; Schulz R; Seeger W; Grimminger F; Weissmann N
Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(6):1639-51.
2008: Klein Martina; Schermuly Ralph T; Ellinghaus Peter; Milting Hendrik; Riedl Bernd; Nikolova Sevdalina; Pullamsetti Soni S; Weissmann Norbert; Dony Eva; Savai Rajkumar; Ghofrani Hossein A; Grimminger Friedrich; Busch Andreas E; Schäfer Stefan
Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.
Circulation 2008;118(20):2081-90.
2008: Butrous Ghazwan; Ghofrani Hossein Ardeschir; Grimminger Friedrich
Pulmonary vascular disease in the developing world.
Circulation 2008;118(17):1758-66.
2008: Hoeper M M; Ghofrani H A; Grimminger F; Rosenkranz S
[Dana Point: what is new in the treatment of pulmonary hypertension?]
Deutsche medizinische Wochenschrift (1946) 2008;133 Suppl 6():S191-5.
2008: Schermuly R; Grimminger F
[Update in basic research in the therapy of pulmonary arterial hypertension]
Deutsche medizinische Wochenschrift (1946) 2008;133 Suppl 6():S170-2.
2008: Kiss Ladislau; Bier Jens; Röder Yasmin; Weissmann Norbert; Grimminger Friedrich; Seeger Werner
Direct and simultaneous profiling of epoxyeicosatrienoic acid enantiomers by capillary tandem column chiral-phase liquid chromatography with dual online photodiode array and tandem mass spectrometric detection.
Analytical and bioanalytical chemistry 2008;392(4):717-26.
2008: Voswinckel Robert; Reichenberger Frank; Enke Beate; Kreckel Andre; Krick Stefanie; Gall Henning; Schermuly Ralph Theo; Grimminger Friedrich; Rubin Lewis J; Olschewski Horst; Seeger Werner; Ghofrani Hossein A
Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2008;21(5):824-32.
2008: Li Shu; Tabar Sarvenaz Shafiei; Malec Viktor; Eul Bastian G; Klepetko Walter; Weissmann Norbert; Grimminger Friedrich; Seeger Werner; Rose Frank; Hänze Jörg
NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts.
Antioxidants & redox signaling 2008;10(10):1687-98.
2008: Schermuly R T; Stasch J-P; Pullamsetti S S; Middendorff R; Müller D; Schlüter K-D; Dingendorf A; Hackemack S; Kolosionek E; Kaulen C; Dumitrascu R; Weissmann N; Mittendorf J; Klepetko W; Seeger W; Ghofrani H A; Grimminger F
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(4):881-91.
2008: Kwapiszewska Grazyna; Wygrecka Malgorzata; Marsh Leigh M; Schmitt Sigrid; Trösser Roger; Wilhelm Jochen; Helmus Katja; Eul Bastian; Zakrzewicz Anna; Ghofrani Hossein A; Schermuly Ralph T; Bohle Rainer M; Grimminger Friedrich; Seeger Werner; Eickelberg Oliver; Fink Ludger; Weissmann Norbert
Fhl-1, a new key protein in pulmonary hypertension.
Circulation 2008;118(11):1183-94.
2008: Ahlbrecht Katrin; Schmitz Judith; Seay Ulrike; Schwarz Christine; Mittnacht-Kraus Rita; Gaumann Andreas; Haberberger Rainer V; Herold Susanne; Breier Georg; Grimminger Friedrich; Seeger Werner; Voswinckel Robert
Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development.
American journal of respiratory cell and molecular biology 2008;39(2):163-70.
2008: Lai Ying-Ju; Pullamsetti Soni Savai; Dony Eva; Weissmann Norbert; Butrous Ghazwan; Banat Gamal-Andre; Ghofrani Hossein Ardeschir; Seeger Werner; Grimminger Friedrich; Schermuly Ralph Theo
Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.
American journal of respiratory and critical care medicine 2008;178(2):188-96.
2008: Wilkins M R; Wharton J; Grimminger F; Ghofrani H A
Phosphodiesterase inhibitors for the treatment of pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(1):198-209.
2008: Vadász István; Schermuly Ralph T; Ghofrani Hossein A; Rummel Sebastian; Wehner Susan; Mühldorfer Inge; Schäfer Klaus P; Seeger Werner; Morty Rory E; Grimminger Friedrich; Weissmann Norbert
The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs.
Critical care medicine 2008;36(5):1543-50.
2008: Buerke Ute; Carter Justin M; Schlitt Axel; Russ Martin; Schmidt Hendrik; Sibelius Ulf; Grandel Ulrich; Grimminger Friedrich; Seeger Werner; Mueller-Werdan Ursula; Werdan Karl; Buerke Michael
Apoptosis contributes to septic cardiomyopathy and is improved by simvastatin therapy.
Shock (Augusta, Ga.) 2008;29(4):497-503.
2008: Dony E; Lai Y-J; Dumitrascu R; Pullamsetti S S; Savai R; Ghofrani H A; Weissmann N; Schudt C; Flockerzi D; Seeger W; Grimminger F; Schermuly R T
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(3):599-610.
2008: Kiss Ladislau; Röder Yasmin; Bier Jens; Weissmann Norbert; Seeger Werner; Grimminger Friedrich
Direct eicosanoid profiling of the hypoxic lung by comprehensive analysis via capillary liquid chromatography with dual online photodiode-array and tandem mass-spectrometric detection.
Analytical and bioanalytical chemistry 2008;390(2):697-714.
2008: Kitowska Kamila; Zakrzewicz Dariusz; Königshoff Melanie; Chrobak Izabella; Grimminger Friedrich; Seeger Werner; Bulau Patrick; Eickelberg Oliver
Functional role and species-specific contribution of arginases in pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2008;294(1):L34-45.
2008: Kirsch Mark; Kemp-Harper Barbara; Weissmann Norbert; Grimminger Friedrich; Schmidt Harald H H W
Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up-regulation of NO-cGMP signaling.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):30-40.
2008: Dumitrascu Rio; Koebrich Silke; Dony Eva; Weissmann Norbert; Savai Rajkumar; Pullamsetti Soni S; Ghofrani Hossein A; Samidurai Arun; Traupe Horst; Seeger Werner; Grimminger Friedrich; Schermuly Ralph T
Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.
BMC pulmonary medicine 2008;8():25.
2007: Reichenberger Frank; Kohstall Markus G; Seeger Timon; Olschewski Horst; Grimminger Friedrich; Seeger Werner; Ghofrani Hossein A
Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function.
Respiratory physiology & neurobiology 2007;159(2):196-201.
2007: Reichenberger F; Voswinckel R; Enke B; Rutsch M; El Fechtali E; Schmehl T; Olschewski H; Schermuly R; Weissmann N; Ghofrani H A; Grimminger F; Mayer E; Seeger W
Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(5):922-7.
2007: Weissmann Norbert; Gerigk Boris; Kocer Ozlem; Nollen Matthias; Hackemack Sascha; Ghofrani Hossein Ardeschir; Schermuly Ralph Theo; Butrous Ghazwan; Schulz Andreas; Roth Markus; Seeger Werner; Grimminger Friedrich
Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide.
Respiratory medicine 2007;101(10):2125-32.
2007: Mittal Manish; Roth Markus; König Peter; Hofmann Simone; Dony Eva; Goyal Parag; Selbitz Anne-Christin; Schermuly Ralph Theo; Ghofrani Hossein Ardeschir; Kwapiszewska Grazyna; Kummer Wolfgang; Klepetko Walter; Hoda Mir Ali Reza; Fink Ludger; Hänze Jörg; Seeger Werner; Grimminger Friedrich; Schmidt Harald H H W; Weissmann Norbert
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.
Circulation research 2007;101(3):258-67.
2007: Dietrich Alexander; Kalwa Hermann; Fuchs Beate; Grimminger Friedrich; Weissmann Norbert; Gudermann Thomas
In vivo TRPC functions in the cardiopulmonary vasculature.
Cell calcium 2007;42(2):233-44.
2007: Savai Rajkumar; Schermuly Ralph Theo; Pullamsetti Soni Savai; Schneider Michael; Greschus Susanne; Ghofrani Hossein Ardeschir; Traupe Horst; Grimminger Friedrich; Banat Gamal-Andre
A combination hybrid-based vaccination/adoptive cellular therapy to prevent tumor growth by involvement of T cells.
Cancer research 2007;67(11):5443-53.
2007: Hänze Jörg; Weissmann Norbert; Grimminger Friedrich; Seeger Werner; Rose Frank
Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling.
Thrombosis and haemostasis 2007;97(5):774-87.
2007: Schermuly Ralph Theo; Pullamsetti Soni Savai; Kwapiszewska Grazyna; Dumitrascu Rio; Tian Xia; Weissmann Norbert; Ghofrani Hossein Ardeschir; Kaulen Christina; Dunkern Torsten; Schudt Christian; Voswinckel Robert; Zhou Jiang; Samidurai Arun; Klepetko Walter; Paddenberg Renate; Kummer Wolfgang; Seeger Werner; Grimminger Friedrich
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
Circulation 2007;115(17):2331-9.
2007: Günther A; Enke B; Markart P; Hammerl P; Morr H; Behr J; Stähler G; Seeger W; Grimminger F; Leconte I; Roux S; Ghofrani H-A
Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(4):713-9.
2007: Schaefer Martina Barbara; Ott Juliane; Mohr Andrea; Bi Ming Hua; Grosz Andrea; Weissmann Norbert; Ishii Satoshi; Grimminger Friedrich; Seeger Werner; Mayer Konstantin
Immunomodulation by n-3- versus n-6-rich lipid emulsions in murine acute lung injury--role of platelet-activating factor receptor.
Critical care medicine 2007;35(2):544-54.
2007: Bulau Patrick; Zakrzewicz Dariusz; Kitowska Kamila; Leiper James; Gunther Andreas; Grimminger Friedrich; Eickelberg Oliver
Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA.
American journal of physiology. Lung cellular and molecular physiology 2007;292(1):L18-24.
2007: Schermuly Ralph T; Pullamsetti Soni S; Breitenbach Susanne C; Weissmann Norbert; Ghofrani Hossein A; Grimminger Friedrich; Nilius Sigrid M; Schrör Karsten; Kirchrath Jutta M; Seeger Werner; Rose Frank
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs.
Respiratory research 2007;8():4.
2007: Rosengarten Bernhard; Hecht Mirko; Auch Dieter; Ghofrani Hossein Ardeschir; Schermuly Ralf Theo; Grimminger Friedrich; Kaps Manfred
Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats.
Cerebrovascular diseases (Basel, Switzerland) 2007;23(2-3):140-7.
2006: Weissmann Norbert; Dietrich Alexander; Fuchs Beate; Kalwa Hermann; Ay Mahmut; Dumitrascu Rio; Olschewski Andrea; Storch Ursula; Mederos y Schnitzler Michael; Ghofrani Hossein Ardeschir; Schermuly Ralph Theo; Pinkenburg Olaf; Seeger Werner; Grimminger Friedrich; Gudermann Thomas
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19093-8.
2006: Ghofrani H A; Rosenkranz S; Grimminger F
[Future aspects of the treatment of pulmonary arterial hypertension.]
Deutsche medizinische Wochenschrift (1946) 2006;131(49 Suppl 9):S338-40.
2006: Ghofrani H A; Grimminger F
[Treatment of pulmonary arterial hypertension: phosphodiesterase-5 inhibitors]
Deutsche medizinische Wochenschrift (1946) 2006;131(49 Suppl 9):S311-4.
2006: Voswinckel Robert; Enke Beate; Reichenberger Frank; Kohstall Markus; Kreckel Andree; Krick Stefanie; Gall Henning; Gessler Tobias; Schmehl Thomas; Ghofrani Hossein A; Schermuly Ralph Theo; Grimminger Friedrich; Rubin Lewis J; Seeger Werner; Olschewski Horst
Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.
Journal of the American College of Cardiology 2006;48(8):1672-81.
2006: Ghofrani Hossein A; Voswinckel Robert; Reichenberger Frank; Weissmann Norbert; Schermuly Ralph T; Seeger Werner; Grimminger Friedrich
Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies.
Cardiovascular research 2006;72(1):30-40.
2006: Yildirim Ali O; Bulau Patrick; Zakrzewicz Dariusz; Kitowska Kamila E; Weissmann Norbert; Grimminger Friedrich; Morty Rory E; Eickelberg Oliver
Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases.
American journal of respiratory cell and molecular biology 2006;35(4):436-43.
2006: Weissmann Norbert; Grimminger Friedrich; Seeger Werner
Hypoxia in lung vascular biology and disease.
Cardiovascular research 2006;71(4):618-9.
2006: Reichenberger F; Voswinckel R; Steveling E; Enke B; Kreckel A; Olschewski H; Grimminger F; Seeger W; Ghofrani H A
Sildenafil treatment for portopulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(3):563-7.
2006: Weissmann Norbert; Sommer Natascha; Schermuly Ralph Theo; Ghofrani Hossein Ardeschir; Seeger Werner; Grimminger Friedrich
Oxygen sensors in hypoxic pulmonary vasoconstriction.
Cardiovascular research 2006;71(4):620-9.
2006: Ghofrani Hossein A; Osterloh Ian H; Grimminger Friedrich
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.
Nature reviews. Drug discovery 2006;5(8):689-702.
2006: Ghofrani H A; Schermuly R T; Weissmann N; Seeger W; Grimminger F
[Reverse remodeling -- paradigm shift in the treatment of pulmonary hypertension]
Deutsche medizinische Wochenschrift (1946) 2006;131(16):871-4.
2006: Voswinckel R; Ahlbrecht K; Wolff J C; Weissmann N; Fehrenbach H; Yildirim A O; Grimminger F; Seeger W
[Pulmonary tissue regeneration -- a hope for the future]
Deutsche medizinische Wochenschrift (1946) 2006;131(16):865-8.
2006: Pullamsetti Soni Savai; Maring Daniel; Ghofrani Hossein Ardeschir; Mayer Konstantin; Weissmann Norbert; Rosengarten Bernhard; Lehner Martin; Schudt Christian; Boer Rainer; Grimminger Friedrich; Seeger Werner; Schermuly Ralph Theo
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Thrombosis and haemostasis 2006;95(4):720-7.
2006: Mayer K; Schaefer M; Walmrath H; Grimminger F; Seeger W
[Nutrition and immunonutrition in septic patients]
Der Internist 2006;47(4):374, 376-82.
2006: Pokreisz Peter; Fleming Ingrid; Kiss Ladislau; Barbosa-Sicard Eduardo; Fisslthaler Beate; Falck John R; Hammock Bruce D; Kim In-Hae; Szelid Zsolt; Vermeersch Pieter; Gillijns Hilde; Pellens Marijke; Grimminger Friedrich; van Zonneveld Anton-Jan; Collen Desire; Busse Rudi; Janssens Stefan
Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.
Hypertension 2006;47(4):762-70.
2006: Weissmann Norbert; Zeller Stefanie; Schäfer Rolf U; Turowski Carmen; Ay Mahmut; Quanz Karin; Ghofrani Hossein A; Schermuly Ralph T; Fink Ludger; Seeger Werner; Grimminger Friedrich
Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction.
American journal of respiratory cell and molecular biology 2006;34(4):505-13.
2006: Renigunta Aparna; Krasteva Gabriela; König Peter; Rose Frank; Klepetko Walter; Grimminger Friedrich; Seeger Werner; Hänze Jörg
DNA transfer into human lung cells is improved with Tat-RGD peptide by caveoli-mediated endocytosis.
Bioconjugate chemistry 2006;17(2):327-34.
2006: Savai Rajkumar; Schermuly Ralph Theo; Schneider Michael; Pullamsetti Soni Savai; Grimminger Friedrich; Seeger Werner; Banat Gamal-Andre
Hybrid-primed lymphocytes and hybrid vaccination prevent tumor growth of lewis lung carcinoma in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(2):175-87.
2006: Hattar Katja; Grandel Ulrich; Moeller Alexander; Fink Ludger; Iglhaut Julia; Hartung Thomas; Morath Siegfried; Seeger Werner; Grimminger Friedrich; Sibelius Ulf
Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-[alpha] in mediating LTA-induced interleukin-8 generation.
Critical care medicine 2006;34(3):835-41.
2006: Renigunta Aparna; Hild Christiane; Rose Frank; Klepetko Walter; Grimminger Friedrich; Seeger Werner; Hänze Jörg
Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia.
FEBS letters 2006;580(3):900-3.
2006: Grimm Helmut; Mertes Norbert; Goeters Christiane; Schlotzer Ewald; Mayer Konstantin; Grimminger Friedrich; Fürst Peter
Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients.
European journal of nutrition 2006;45(1):55-60.
2006: Voswinckel Robert; Ghofrani Hossein A; Grimminger Friedrich; Seeger Werner; Olschewski Horst
Inhaled treprostinil [corrected] for treatment of chronic pulmonary arterial hypertension.
Annals of internal medicine 2006;144(2):149-50.
2006: Dumitrascu Rio; Weissmann Norbert; Ghofrani Hossein Ardeschir; Dony Eva; Beuerlein Knut; Schmidt Harald; Stasch Johannes-Peter; Gnoth Mark Jean; Seeger Werner; Grimminger Friedrich; Schermuly Ralph Theo
Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling.
Circulation 2006;113(2):286-95.
2006: Grandel Ulrich; Benkelmann Robin; Buerke Michael; Kiss Ladislau; Hattar Katja; Mayer Konstantin; Heep Martina; Seeger Werner; Grimminger Friedrich; Sibelius Ulf
Free arachidonic versus eicosapentaenoic acid differentially influences the potency of bacterial exotoxins to provoke myocardial depression in isolated rat hearts.
Critical care medicine 2006;34(1):118-26.
2006: Eul Bastian; Rose Frank; Krick Stefanie; Savai Rajkumar; Goyal Parag; Klepetko Walter; Grimminger Friedrich; Weissmann Norbert; Seeger Werner; Hänze Jörg
Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(1):163-5.
2006: Schermuly Ralph Theo; Schulz Andreas; Ghofrani Hossein Ardeschir; Breitenbach Christina Susanne; Weissmann Norbert; Hildebrand Michael; Kurz Julia; Grimminger Friedrich; Seeger Werner
Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: rapid tolerance development.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2006;19(3):353-63.
2006: Weissmann Norbert; Schermuly Ralph T; Ghofrani Hossein A; Hänze Jörg; Goyal Parag; Grimminger Friedrich; Seeger Werner
Hypoxic pulmonary vasoconstriction--triggered by an increase in reactive oxygen species?
Novartis Foundation symposium 2006;272():196-208; discussion 208-17.
2006: Rosengarten B; Schermuly R T; Voswinckel R; Kohstall M G; Olschewski H; Weissmann N; Seeger W; Kaps M; Grimminger F; Ghofrani H A
Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension.
Cerebrovascular diseases (Basel, Switzerland) 2006;21(3):194-200.
2005: Galiè Nazzareno; Ghofrani Hossein A; Torbicki Adam; Barst Robyn J; Rubin Lewis J; Badesch David; Fleming Thomas; Parpia Tamiza; Burgess Gary; Branzi Angelo; Grimminger Friedrich; Kurzyna Marcin; Simonneau Gérald;
Sildenafil citrate therapy for pulmonary arterial hypertension.
The New England journal of medicine 2005;353(20):2148-57.
2005: Schermuly Ralph Theo; Dony Eva; Ghofrani Hossein Ardeschir; Pullamsetti Soni; Savai Rajkumar; Roth Markus; Sydykov Akylbek; Lai Ying Ju; Weissmann Norbert; Seeger Werner; Grimminger Friedrich
Reversal of experimental pulmonary hypertension by PDGF inhibition.
The Journal of clinical investigation 2005;115(10):2811-21.
2005: Savai Rajkumar; Wolf Joachim C; Greschus Susanne; Eul Bastian G; Schermuly Ralph T; Hänze Jörg; Voswinckel Robert; Langheinrich Alexander C; Grimminger Friedrich; Traupe Horst; Seeger Werner; Rose Frank
Analysis of tumor vessel supply in Lewis lung carcinoma in mice by fluorescent microsphere distribution and imaging with micro- and flat-panel computed tomography.
The American journal of pathology 2005;167(4):937-46.
2005: Vadász István; Morty Rory E; Olschewski Andrea; Königshoff Melanie; Kohstall Markus G; Ghofrani Hossein A; Grimminger Friedrich; Seeger Werner
Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase.
American journal of respiratory cell and molecular biology 2005;33(4):343-54.
2005: Hattar Katja; van Bürck Sandra; Bickenbach Annette; Grandel Ulrich; Maus Ulrich; Lohmeyer Jürgen; Csernok Elena; Hartung Thomas; Seeger Werner; Grimminger Friedrich; Sibelius Ulf
Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation.
Journal of leukocyte biology 2005;78(4):992-1000.
2005: Weissmann Norbert; Manz Daniel; Buchspies Daniela; Keller Stephan; Mehling Tanja; Voswinckel Robert; Quanz Karin; Ghofrani Hossein A; Schermuly Ralph T; Fink Ludger; Seeger Werner; Gassmann Max; Grimminger Friedrich
Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
Thrombosis and haemostasis 2005;94(3):630-8.
2005: Ghofrani Hossein A; Seeger Werner; Grimminger Friedrich
Imatinib for the treatment of pulmonary arterial hypertension.
The New England journal of medicine 2005;353(13):1412-3.
2005: Friese Georg; Lohmeyer Jürgen; Seeger Werner; Grimminger Friedrich; Ghofrani Hossein Ardeschir
[HIV-associated pulmonary hypertension ]
Herz 2005;30(6):481-5.
2005: Markart P; Hundack L; Ghofrani A; Grimminger F; Seeger W; Günther A
[Idiopathic interstitial pneumonias: pathomechanisms and therapeutic options]
Pneumologie (Stuttgart, Germany) 2005;59(8):554-61.
2005: Grandel Ulrich; Hopf Michael; Buerke Michael; Hattar Katja; Heep Martina; Fink Ludger; Bohle Rainer M; Morath Siegfried; Hartung Thomas; Pullamsetti Soni; Schermuly Ralph T; Seeger Werner; Grimminger Friedrich; Sibelius Ulf
Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts.
Circulation 2005;112(5):691-8.
2005: Savai Rajkumar; Schermuly Ralph Theo; Voswinckel Robert; Renigunta Aparna; Reichmann Bernd; Eul Bastian; Grimminger Friedrich; Seeger Werner; Rose Frank; Hänze Jörg
HIF-1alpha attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model.
International journal of oncology 2005;27(2):393-400.
2005: Schermuly Ralph Theo; Yilmaz Hüseyin; Ghofrani Hossein Ardeschir; Woyda Kathrin; Pullamsetti Soni; Schulz Andreas; Gessler Tobias; Dumitrascu Rio; Weissmann Norbert; Grimminger Friedrich; Seeger Werner
Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2005;172(3):358-63.
2005: Pullamsetti Soni; Kiss Ladislau; Ghofrani Hossein Ardeschir; Voswinckel Robert; Haredza Peter; Klepetko Walter; Aigner Clemens; Fink Ludger; Muyal Jai Prakash; Weissmann Norbert; Grimminger Friedrich; Seeger Werner; Schermuly Ralph Theo
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1175-7.
2005: Ghofrani Hossein Ardeschir; Voswinckel Robert; Reichenberger Frank; Grimminger Friedrich; Seeger Werner
[Emerging therapies for the treatment of pulmonary arterial hypertension]
Herz 2005;30(4):296-302.
2005: Krick Stefanie; Hänze Jörg; Eul Bastian; Savai Rajkumar; Seay Ulrike; Grimminger Friedrich; Lohmeyer Jürgen; Klepetko Walter; Seeger Werner; Rose Frank
Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1alpha and an autocrine angiotensin system.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):857-9.
2005: Krick Stefanie; Eul Bastian G; Hänze Jörg; Savai Rajkumar; Grimminger Friedrich; Seeger Werner; Rose Frank
Role of hypoxia-inducible factor-1alpha in hypoxia-induced apoptosis of primary alveolar epithelial type II cells.
American journal of respiratory cell and molecular biology 2005;32(5):395-403.
2005: Goyal Parag; Weissmann Norbert; Rose Frank; Grimminger Friedrich; Schäfers Hans J; Seeger Werner; Hänze Jörg
Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells.
Biochemical and biophysical research communications 2005;329(1):32-9.
2005: Olschewski H; Ghofrani A; Enke B; Reichenberger F; Voswinckel R; Kreckel A; Ghofrani S; Wiedemann R; Schulz R; Grimminger F; Seeger W
[Therapy of pulmonary arterial hypertension]
Der Internist 2005;46(3):341-9.
2005: Vadász István; Morty Rory E; Kohstall Markus G; Olschewski Andrea; Grimminger Friedrich; Seeger Werner; Ghofrani Hossein A
Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome?
American journal of respiratory and critical care medicine 2005;171(5):469-79.
2005: Pullamsetti Soni; Krick Stefanie; Yilmaz Hüseyin; Ghofrani Hossein Ardeschir; Schudt Christian; Weissmann Norbert; Fuchs Beate; Seeger Werner; Grimminger Friedrich; Schermuly Ralph Theo
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.
Respiratory research 2005;6():128.
2005: Weissmann Norbert; Kuzkaya Nermin; Fuchs Beate; Tiyerili Vedat; Schäfer Rolf U; Schütte Hartwig; Ghofrani Hossein A; Schermuly Ralph T; Schudt Christian; Sydykov Akylbek; Egemnazarow Bakytbek; Seeger Werner; Grimminger Friedrich
Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy.
Respiratory research 2005;6():86.
2005: Schermuly Ralph Theo; Inholte Christiane; Ghofrani Hossein Ardeschir; Gall Henning; Weissmann Norbert; Weidenbach Andreas; Seeger Werner; Grimminger Friedrich
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.
Respiratory research 2005;6():76.
2004: Schmidt R; Luboeinski T; Markart P; Ruppert C; Daum C; Grimminger F; Seeger W; Günther A
Alveolar antioxidant status in patients with acute respiratory distress syndrome.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(6):994-9.
2004: Ghofrani Hossein A; Voswinckel Robert; Reichenberger Frank; Olschewski Horst; Haredza Peter; Karadas Burcu; Schermuly Ralph T; Weissmann Norbert; Seeger Werner; Grimminger Friedrich
Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study.
Journal of the American College of Cardiology 2004;44(7):1488-96.
2004: Wygrecka Malgorzata; Markart Philipp; Ruppert Clemens; Kuchenbuch Tim; Fink Ludger; Bohle Rainer Maria; Grimminger Friedrich; Seeger Werner; Günther Andreas
Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application.
Thrombosis and haemostasis 2004;92(3):529-40.
2004: Ghofrani Hossein A; Reichenberger Frank; Kohstall Markus G; Mrosek Eike H; Seeger Timon; Olschewski Horst; Seeger Werner; Grimminger Friedrich
Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial.
Annals of internal medicine 2004;141(3):169-77.
2004: Ghofrani Hossein A; Pepke-Zaba Joanna; Barbera Joan A; Channick Richard; Keogh Anne M; Gomez-Sanchez Miguel A; Kneussl Meinhard; Grimminger Friedrich
Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension.
Journal of the American College of Cardiology 2004;43(12 Suppl S):68S-72S.
2004: Goyal Parag; Weissmann Norbert; Grimminger Friedrich; Hegel Cornelia; Bader Lucius; Rose Frank; Fink Ludger; Ghofrani Hossein A; Schermuly Ralph T; Schmidt Harald H H W; Seeger Werner; Hänze Jörg
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species.
Free radical biology & medicine 2004;36(10):1279-88.
2004: Schermuly Ralph Theo; Kreisselmeier Klaus Peter; Ghofrani Hossein Ardeschir; Samidurai Arun; Pullamsetti Soni; Weissmann Norbert; Schudt Christian; Ermert Leander; Seeger Werner; Grimminger Friedrich
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Circulation research 2004;94(8):1101-8.
2004: Weissmann Norbert; Vogels Henrik; Schermuly Ralph T; Ghofrani Hossein A; Hänze Jörg; Fink Ludger; Rose Frank; Seeger Werner; Grimminger Friedrich
Measurement of exhaled hydrogen peroxide from rabbit lungs.
Biological chemistry 2004;385(3-4):259-64.
2004: Ghofrani H A; Friese G; Discher T; Olschewski H; Schermuly R T; Weissmann N; Seeger W; Grimminger F; Lohmeyer J
Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(2):321-6.
2004: Weissmann Norbert; Akkayagil Ercan; Quanz Karin; Schermuly Ralph Theo; Ghofrani Hossein Ardeschir; Fink Ludger; Hänze Jörg; Rose Frank; Seeger Werner; Grimminger Friedrich
Basic features of hypoxic pulmonary vasoconstriction in mice.
Respiratory physiology & neurobiology 2004;139(2):191-202.
2004: Schmidt Reinhold; Schäfer Christoph; Luboeinski Thomas; Löckinger Alexander; Hermle Gerd; Grimminger Friedrich; Seeger Werner; Ghofrani Ardeschir; Schütte Hartwig; Günther Andreas
Increase in alveolar antioxidant levels in hyperoxic and anoxic ventilated rabbit lungs during ischemia.
Free radical biology & medicine 2004;36(1):78-89.
2004: Muth H; Maus U; Wygrecka M; Lohmeyer J; Grimminger F; Seeger W; Günther A
Pro- and antifibrinolytic properties of human pulmonary microvascular versus artery endothelial cells: impact of endotoxin and tumor necrosis factor-alpha.
Critical care medicine 2004;32(1):217-26.
2004: Schermuly Ralph T; Kreisselmeier Klaus P; Ghofrani Hossein A; Yilmaz Hüseyin; Butrous Ghazwan; Ermert Leander; Ermert Monika; Weissmann Norbert; Rose Frank; Guenther Andreas; Walmrath Dieter; Seeger Werner; Grimminger Friedrich
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;169(1):39-45.
2003: Hänze Jörg; Eul Bastian G; Savai Rajkumar; Krick Stefanie; Goyal Parag; Grimminger Friedrich; Seeger Werner; Rose Frank
RNA interference for HIF-1alpha inhibits its downstream signalling and affects cellular proliferation.
Biochemical and biophysical research communications 2003;312(3):571-7.
2003: Eickelberg Oliver; Yeager Michael E; Grimminger Friedrich
The tantalizing triplet of pulmonary hypertension-BMP receptors, serotonin receptors, and angiopoietins.
Cardiovascular research 2003;60(3):465-7.
2003: Rose Frank; Hattar Katja; Gakisch Sybille; Grimminger Friedrich; Olschewski Horst; Seeger Werner; Tschuschner Annette; Schermuly Ralph T; Weissmann Norbert; Hanze Jörg; Sibelius Ulf; Ghofrani Hossein A
Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost.
Thrombosis and haemostasis 2003;90(6):1141-9.
2003: Günther Andreas; Lübke Norbert; Ermert Monika; Schermuly Ralph T; Weissmann Norbert; Breithecker Andreas; Markart Philipp; Ruppert Clemens; Quanz Karin; Ermert Leander; Grimminger Friedrich; Seeger Werner
Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits.
American journal of respiratory and critical care medicine 2003;168(11):1358-65.
2003: Weissmann Norbert; Ebert Nadine; Ahrens Marit; Ghofrani Hossein A; Schermuly Ralph T; Hänze Jörg; Fink Ludger; Rose Frank; Conzen Jörg; Seeger Werner; Grimminger Friedrich
Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2003;29(6):721-32.
2003: Mayer Konstantin; Meyer Sandra; Reinholz-Muhly Marion; Maus Ulrich; Merfels Martina; Lohmeyer Jürgen; Grimminger Friedrich; Seeger Werner
Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4837-43.
2003: Mayer Konstantin; Fegbeutel Christine; Hattar Katja; Sibelius Ulf; Krämer Hans-Joachim; Heuer Kai-Uwe; Temmesfeld-Wollbrück Bettina; Gokorsch Stephanie; Grimminger Friedrich; Seeger Werner
Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation.
Intensive care medicine 2003;29(9):1472-81.
2003: Schermuly R T; Leuchte H; Ghofrani H A; Weissmann N; Rose F; Kohstall M; Olschewski H; Schudt C; Grimminger F; Seeger W; Walmrath D
Zardaverine and aerosolised iloprost in a model of acute respiratory failure.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(2):342-7.
2003: Ghofrani Hossein A; Rose Frank; Schermuly Ralph T; Olschewski Horst; Wiedemann Ralph; Kreckel André; Weissmann Norbert; Ghofrani Stefanie; Enke Beate; Seeger Werner; Grimminger Friedrich
Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension.
Journal of the American College of Cardiology 2003;42(1):158-64.
2003: Ermert M; Pantazis C; Duncker H-R; Grimminger F; Seeger W; Ermert L
In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue.
Cytokine 2003;22(3-4):89-100.
2003: Mayer Konstantin; Gokorsch Stephanie; Fegbeutel Christine; Hattar Katja; Rosseau Simone; Walmrath Dieter; Seeger Werner; Grimminger Friedrich
Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis.
American journal of respiratory and critical care medicine 2003;167(10):1321-8.
2003: Schulz Richard; Fegbeutel Christine; Althoff Andre; Traupe Horst; Grimminger Friedrich; Seeger Werner
Central sleep apnoea and unilateral diaphragmatic paralysis associated with vertebral artery compression of the medulla oblongata.
Journal of neurology 2003;250(4):503-5.
2003: Ghofrani Hossein A; Schermuly Ralph T; Rose Frank; Wiedemann Ralph; Kohstall Markus G; Kreckel André; Olschewski Horst; Weissmann Norbert; Enke Beate; Ghofrani Stefanie; Seeger Werner; Grimminger Friedrich
Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension.
American journal of respiratory and critical care medicine 2003;167(8):1139-41.
2003: Schütte Hartwig; Schell Alexander; Schäfer Christoph; Ghofrani Ardeschir; Theo Schermuly Ralph; Seeger Werner; Grimminger Friedrich
Subthreshold doses of nebulized prostacyclin and rolipram synergistaically protect against lung ischemia-reperfusion.
Transplantation 2003;75(6):814-21.
2003: Sibelius Ulf; Grandel Ulrich; Buerke Michael; Kiss Ladislau; Klingenberger Pascal; Heep Martina; Bournelis Emmanoyil; Seeger Werner; Grimminger Friedrich
Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
Critical care medicine 2003;31(3):683-8.
2003: Weissmann Norbert; Nollen Matthias; Gerigk Boris; Ardeschir Ghofrani Hossein; Schermuly Ralph Theo; Gunther Andreas; Quanz Karin; Fink Ludger; Hänze Jörg; Rose Frank; Seeger Werner; Grimminger Friedrich
Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H931-8.
2003: Ruppert Clemens; Markart Philipp; Schmidt Reinhold; Grimminger Friedrich; Seeger Werner; Lehr Claus-Michael; Günther Andreas
Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin.
Thrombosis and haemostasis 2003;89(1):53-64.
2003: Dailey Lea Ann; Schmehl Thomas; Gessler Tobias; Wittmar Matthias; Grimminger Friedrich; Seeger Werner; Kissel Thomas
Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features.
Journal of controlled release : official journal of the Controlled Release Society 2003;86(1):131-44.
2003: Markart Philipp; Ruppert Clemens; Grimminger Friedrich; Seeger Werner; Günther Andreas
Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C.
American journal of physiology. Lung cellular and molecular physiology 2003;284(1):L69-76.
2003: Grandel Ulrich; Grimminger Friedrich
Endothelial responses to bacterial toxins in sepsis.
Critical reviews in immunology 2003;23(4):267-99.
2002: Olschewski H; Ghofrani A; Wiedemann R; Rose F; Enke B; Gessler T; Voswinckel R; Kohstall M; Grimminger F; Seeger W
[Pulmonary hypertension]
Der Internist 2002;43(12):1498, 1501-9.
2002: Ghofrani H A; Olschewski H; Seeger W; Grimminger F
[Sildenafil for treatment of severe pulmonary hypertension and commencing right-heart failure]
Pneumologie (Stuttgart, Germany) 2002;56(11):665-72.
2002: Ghofrani Hossein A; Rose Frank; Schermuly Ralph T; Olschewski Horst; Wiedemann Ralph; Weissmann Norbert; Schudt Christian; Tenor Herrmann; Seeger Werner; Grimminger Friedrich
Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension.
Critical care medicine 2002;30(11):2489-92.
2002: Schermuly Ralph Theo; Schulz Andreas; Ghofrani Hossein Ardeschir; Meidow Arne; Rose Frank; Roehl Axel; Weissmann Norbert; Hildebrand Michael; Kurz Julia; Grimminger Friedrich; Walmrath Dieter; Seeger Werner
Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs.
The Journal of pharmacology and experimental therapeutics 2002;303(2):741-5.
2002: Schmidt R; Meier U; Markart P; Grimminger F; Velcovsky H G; Morr H; Seeger W; Günther A
Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease.
American journal of physiology. Lung cellular and molecular physiology 2002;283(5):L1079-85.
2002: Sibelius Ulf; Hattar Katja; Hoffmann Sabine; Mayer Konstantin; Grandel Ulrich; Schenkel Angelika; Seeger Werner; Grimminger Friedrich
Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
Critical care medicine 2002;30(10):2306-12.
2002: Pruefer Diethard; Makowski Joachim; Schnell Martin; Buerke Ute; Dahm Manfred; Oelert Hellmut; Sibelius Ulf; Grandel Ulrich; Grimminger Friedrich; Seeger Werner; Meyer Jürgen; Darius Harald; Buerke Michael
Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha-toxin.
Circulation 2002;106(16):2104-10.
2002: Rose Frank; Grimminger Friedrich; Appel Jutta; Heller Mathias; Pies Volker; Weissmann Norbert; Fink Ludger; Schmidt Sebastian; Krick Stefanie; Camenisch Gieri; Gassmann Max; Seeger Werner; Hänze Jörg
Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1660-1.
2002: Ghofrani Hossein Ardeschir; Wiedemann Ralph; Rose Frank; Schermuly Ralph T; Olschewski Horst; Weissmann Norbert; Gunther Andreas; Walmrath Dieter; Seeger Werner; Grimminger Friedrich
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial.
Lancet 2002;360(9337):895-900.
2002: Rose Frank; Guthmann Bernd; Tenenbaum Tobias; Fink Ludger; Ghofrani Ardeschir; Weissmann Norbert; König Peter; Ermert Leander; Dahlem Gabriele; Haenze Joerg; Kummer Wolfgang; Seeger Werner; Grimminger Friedrich
Apical, but not basolateral, endotoxin preincubation protects alveolar epithelial cells against hydrogen peroxide-induced loss of barrier function: the role of nitric oxide synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1474-81.
2002: Mayer Konstantin; Merfels Martina; Muhly-Reinholz Marion; Gokorsch Stephanie; Rosseau Simone; Lohmeyer Jürgen; Schwarzer Nicole; Krüll Matthias; Suttorp Norbert; Grimminger Friedrich; Seeger Werner
Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation.
American journal of physiology. Heart and circulatory physiology 2002;283(2):H811-8.
2002: Ruppert Clemens; Schmidt Reinhold; Grimminger Friedrich; Suzuki Yasuhiro; Seeger Werner; Lehr Claus-Michael; Günther Andreas
Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin.
Bioconjugate chemistry 2002;13(4):804-11.
2002: George W; Grimminger F; Krause B
[Communication center in public health]
Versicherungsmedizin / herausgegeben von Verband der Lebensversicherungs-Unternehmen e.V. und Verband der Privaten Krankenversicherung e.V 2002;54(2):84-8.
2002: Hattar Katja; Bickenbach Annette; Csernok Elena; Rosseau Simone; Grandel Ulrich; Seeger Werner; Grimminger Friedrich; Sibelius Ulf
Wegener's granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine cell activation.
Journal of leukocyte biology 2002;71(6):996-1004.
2002: Mayer Konstantin; Schmidt Reinhold; Muhly-Reinholz Marion; Bögeholz Tina; Gokorsch Stephanie; Grimminger Friedrich; Seeger Werner
In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFalpha impact of omega-3 versus omega-6 fatty acids.
Journal of lipid research 2002;43(6):944-51.
2002: Walmrath D; Grimminger F; Pappert D; Knothe C; Obertacke U; Benzing A; Günther A; Schmehl T; Leuchte H; Seeger W
Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on gas exchange and haemodynamics.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(5):805-10.
2002: Günther A; Schmidt R; Harodt J; Schmehl T; Walmrath D; Ruppert C; Grimminger F; Seeger W
Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(5):797-804.
2002: Mayser Peter; Mayer Konstantin; Mahloudjian Mojgan; Benzing Steffen; Krämer Hans-Joachim; Schill Wolf-Bernhard; Seeger Werner; Grimminger Friedrich
A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis.
JPEN. Journal of parenteral and enteral nutrition 2002;26(3):151-8.
2002: Ghofrani H A; Wiedemann R; Rose F; Weissmann N; Schermuly R T; Quanz K; Grimminger F; Seeger W; Olschewski H
Lung cGMP release subsequent to NO inhalation in pulmonary hypertension: responders versus nonresponders.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):664-71.
2002: Schulz R; Baseler G; Ghofrani H A; Grimminger F; Olschewski H; Seeger W
Nocturnal periodic breathing in primary pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):658-63.
2002: Ghofrani Hossein Ardeschir; Wiedemann Ralph; Rose Frank; Olschewski Horst; Schermuly Ralph Theo; Weissmann Norbert; Seeger Werner; Grimminger Friedrich
Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension.
Annals of internal medicine 2002;136(7):515-22.
2002: Hattar Katja; Grandel Ulrich; Bickenbach Annette; Schwarting Andreas; Mayet Werner-Johannes; Bux Jürgen; Jessen Sönke; Fischer Claus; Seeger Werner; Grimminger Friedrich; Sibelius Ulf
Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):3057-64.
2002: Hänze Jörg; Groneberg David A; Rose Frank; Hanisch Anika; Dötsch Jörg; Peiser Christian; Seeger Werner; Rascher Wolfgang; Fischer Axel; Grimminger Friedrich
Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia.
Biochemical and biophysical research communications 2002;291(5):1160-5.
2002: Grandel Ulrich; Reutemann Mathias; Kiss Ladislau; Buerke Michael; Fink Ludger; Bournelis Emmanoyil; Heep Martina; Seeger Werner; Grimminger Friedrich; Sibelius Ulf
Staphylococcal alpha-toxin provokes neutrophil-dependent cardiac dysfunction: role of ICAM-1 and cys-leukotrienes.
American journal of physiology. Heart and circulatory physiology 2002;282(3):H1157-65.
2002: Schmidt Reinhold; Steinhilber Wolfram; Ruppert Clemens; Daum Christina; Grimminger Friedrich; Seeger Werner; Günther Andreas
An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid.
American journal of respiratory and critical care medicine 2002;165(4):470-4.
2002: Rose Frank; Dahlem Gabriele; Guthmann Bernd; Grimminger Friedrich; Maus Ulrich; Hänze Jörg; Duemmer Nils; Grandel Ulrich; Seeger Werner; Ghofrani Hossein Ardeschir
Mediator generation and signaling events in alveolar epithelial cells attacked by S. aureus alpha-toxin.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L207-14.
2002: Mayser P; Grimm H; Grimminger F
n-3 fatty acids in psoriasis.
The British journal of nutrition 2002;87 Suppl 1():S77-82.
2002: Mayer K; Grimm H; Grimminger F; Seeger W
Parenteral nutrition with n-3 lipids in sepsis.
The British journal of nutrition 2002;87 Suppl 1():S69-75.
2002: Buerke Michael; Sibelius Ulf; Grandel Ulrich; Buerke Ute; Grimminger Friedrich; Seeger Werner; Meyer Jürgen; Darius Harald
Staphylococcus aureus alpha toxin mediates polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction.
Shock (Augusta, Ga.) 2002;17(1):30-5.
2002: Fink Ludger; Kohlhoff Stephanie; Stein Maria Magdalena; Hänze Jörg; Weissmann Norbert; Rose Frank; Akkayagil Ercan; Manz Daniel; Grimminger Friedrich; Seeger Werner; Bohle Rainer Maria
cDNA array hybridization after laser-assisted microdissection from nonneoplastic tissue.
The American journal of pathology 2002;160(1):81-90.
2002: Schulz Richard; Hummel Christoph; Heinemann Sabine; Seeger Werner; Grimminger Friedrich
Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia.
American journal of respiratory and critical care medicine 2002;165(1):67-70.
2002: Gessler Tobias; Schmehl Thomas; Olschewski Horst; Grimminger Friedrich; Seeger Werner
Aerosolized vasodilators in pulmonary hypertension.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2002;15(2):117-22.
2001: Walmrath D; Grimminger F; Seeger W
[Severe sepsis--new therapeutic options]
Der Internist 2001;42(12):1619-20, 1623-30.
2001: Olschewski H; Rose F; Grünig E; Ghofrani H A; Walmrath D; Schulz R; Schermuly R; Grimminger F; Seeger W
Cellular pathophysiology and therapy of pulmonary hypertension.
The Journal of laboratory and clinical medicine 2001;138(6):367-77.
2001: Schermuly R T; Roehl A; Weissmann N; Ghofrani H A; Leuchte H; Grimminger F; Seeger W; Walmrath D
Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2001;281(6):L1361-8.
2001: Schulz R; Seeger W; Grimminger F
Serum nitrite/nitrate levels in obstructive sleep apnea.
American journal of respiratory and critical care medicine 2001;164(10 Pt 1):1997-8.
2001: Schermuly R T; Krupnik E; Tenor H; Schudt C; Weissmann N; Rose F; Grimminger F; Seeger W; Walmrath D; Ghofrani H A
Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity.
American journal of respiratory and critical care medicine 2001;164(9):1694-700.
2001: Olschewski H; Olschewski A; Rose F; Schermuly R; Schütte H; Weissmann N; Seeger W; Grimminger F
Physiologic basis for the treatment of pulmonary hypertension.
The Journal of laboratory and clinical medicine 2001;138(5):287-97.
2001: Schütte H; Witzenrath M; Mayer K; Rosseau S; Seeger W; Grimminger F
Short-term "preconditioning" with inhaled nitric oxide protects rabbit lungs against ischemia-reperfusion injury.
Transplantation 2001;72(8):1363-70.
2001: Wiedemann R; Ghofrani H A; Weissmann N; Schermuly R; Quanz K; Grimminger F; Seeger W; Olschewski H
Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation.
Journal of the American College of Cardiology 2001;38(4):1130-6.
2001: Schermuly R T; Weissmann N; Enke B; Ghofrani H A; Forssmann W G; Grimminger F; Seeger W; Walmrath D
Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication.
American journal of respiratory cell and molecular biology 2001;25(2):219-25.
2001: Schütte H; Mayer K; Burger H; Witzenrath M; Gessler T; Seeger W; Grimminger F
Endogenous nitric oxide synthesis and vascular leakage in ischemic-reperfused rabbit lungs.
American journal of respiratory and critical care medicine 2001;164(3):412-8.
2001: Weissmann N; Grimminger F; Olschewski A; Seeger W
Hypoxic pulmonary vasoconstriction: a multifactorial response?
American journal of physiology. Lung cellular and molecular physiology 2001;281(2):L314-7.
2001: Schütte H; Löckinger A; Seeger W; Grimminger F
Aerosolized PGE1, PGI2 and nitroprusside protect against vascular leakage in lung ischaemia-reperfusion.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;18(1):15-22.
2001: Günther A; Walmrath D; Grimminger F; Seeger W
Pathophysiology of acute lung injury.
Seminars in respiratory and critical care medicine 2001;22(3):247-58.
2001: Schulz R; Olschewski H; Grimminger F; Seeger W
[Obstructive sleep apnea and cardiovascular diseases--hypothesis on the pathophysiological interlinks]
Pneumologie (Stuttgart, Germany) 2001;55(6):295-301.
2001: Hattar K; Fink L; Fietzner K; Himmel B; Grimminger F; Seeger W; Sibelius U
Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6287-93.
2001: Ghofrani H A; Kohstall M G; Weissmann N; Schmehl T; Schermuly R T; Seeger W; Grimminger F
Alveolar epithelial barrier functions in ventilated perfused rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(5):L896-904.
2001: Schermuly R T; Günther A; Ermert M; Ermert L; Ghofrani H A; Weissmann N; Grimminger F; Seeger W; Walmrath D
Conebulization of surfactant and urokinase restores gas exchange in perfused lungs with alveolar fibrin formation.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L792-800.
2001: Weissmann N; Winterhalder S; Nollen M; Voswinckel R; Quanz K; Ghofrani H A; Schermuly R T; Seeger W; Grimminger F
NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L638-45.
2001: Rose F; Zeller S A; Chakraborty T; Domann E; Machleidt T; Kronke M; Seeger W; Grimminger F; Sibelius U
Human endothelial cell activation and mediator release in response to Listeria monocytogenes virulence factors.
Infection and immunity 2001;69(2):897-905.
2001: Gessler T; Schmehl T; Hoeper M M; Rose F; Ghofrani H A; Olschewski H; Grimminger F; Seeger W
Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(1):14-9.
2001: Löckinger A; Schütte H; Walmrath D; Seeger W; Grimminger F
Protection against gas exchange abnormalities by pre-aerosolized PGE1, iloprost and nitroprusside in lung ischemia-reperfusion.
Transplantation 2001;71(2):185-93.
2001: Schmidt R; Meier U; Yabut-Perez M; Walmrath D; Grimminger F; Seeger W; Günther A
Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia.
American journal of respiratory and critical care medicine 2001;163(1):95-100.
2001: Hattar K; Sibelius U; Bickenbach A; Csernok E; Seeger W; Grimminger F
Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis.
Journal of leukocyte biology 2001;69(1):89-97.
2001: Grandel U; Sibelius U; Schrickel J; Schmidt D; Buerke M; Fink L; Bournelis E; Heep M; Mayer K; Bohle R M; Seeger W; Grimminger F
Biosynthesis of constitutive nitric oxide synthase-derived nitric oxide attenuates coronary vasoconstriction and myocardial depression in a model of septic heart failure induced by Staphylococcus aureus alpha-toxin.
Critical care medicine 2001;29(1):1-7.
2001: Maus U; Herold S; Muth H; Maus R; Ermert L; Ermert M; Weissmann N; Rosseau S; Seeger W; Grimminger F; Lohmeyer J
Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14.
American journal of physiology. Lung cellular and molecular physiology 2001;280(1):L58-68.
2001: Günther A; Ruppert C; Schmidt R; Markart P; Grimminger F; Walmrath D; Seeger W
Surfactant alteration and replacement in acute respiratory distress syndrome.
Respiratory research 2001;2(6):353-64.
2000: Schulz R; Olschewski H; Grimminger F; Seeger W
[Prevalence of stroke and transitory ischemic attacks in obstructive sleep apnea: a retrospective analyis so f 187 consecutive patients]
Pneumologie (Stuttgart, Germany) 2000;54(12):575-9.
2000: Schulz R; Schmidt D; Blum A; Lopes-Ribeiro X; Lücke C; Mayer K; Olschewski H; Seeger W; Grimminger F
Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy.
Thorax 2000;55(12):1046-51.
2000: Grandel U; Fink L; Blum A; Heep M; Buerke M; Kraemer H J; Mayer K; Bohle R M; Seeger W; Grimminger F; Sibelius U
Endotoxin-induced myocardial tumor necrosis factor-alpha synthesis depresses contractility of isolated rat hearts: evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production.
Circulation 2000;102(22):2758-64.
2000: Weissmann N; Tadic A; Hänze J; Rose F; Winterhalder S; Nollen M; Schermuly R T; Ghofrani H A; Seeger W; Grimminger F
Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)?
American journal of physiology. Lung cellular and molecular physiology 2000;279(4):L683-90.
2000: Schütte H; Witzenrath M; Mayer K; Weissmann N; Schell A; Rosseau S; Seeger W; Grimminger F
The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;279(3):L496-502.
2000: Temmesfeld-Wollbrück B; Mayer K; Grimminger F
Assessment of intestinal tissue oxygenation: the canary sings--but was does the twitter tell us?
Intensive care medicine 2000;26(8):1025-7.
2000: Schulz R; Mahmoudi S; Hattar K; Sibelius U; Olschewski H; Mayer K; Seeger W; Grimminger F
Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):566-70.
2000: Weissmann N; Voswinckel R; Tadic A; Hardebusch T; Ghofrani H A; Schermuly R T; Seeger W; Grimminger F
Nitric oxide (NO)-dependent but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2000;23(2):222-7.
2000: Rose F; Kiss L; Grimminger F; Mayer K; Grandel U; Seeger W; Bieniek E; Sibelius U
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid.
American journal of physiology. Lung cellular and molecular physiology 2000;279(1):L100-9.
2000: Rosseau S; Hammerl P; Maus U; Walmrath H D; Schütte H; Grimminger F; Seeger W; Lohmeyer J
Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology 2000;279(1):L25-35.
2000: Rose F; Heuer K U; Sibelius U; Hombach-Klonisch S; Kiss L; Seeger W; Grimminger F
Targeting lipopolysaccharides by the nontoxic polymyxin B nonapeptide sensitizes resistant Escherichia coli to the bactericidal effect of human neutrophils.
The Journal of infectious diseases 2000;182(1):191-9.
2000: Grimminger F; Rose F; Ghofrani H A; Schermuly R T; Weissmann N; Olschewski H; Walmrath D; Seeger W
[Inhalative strategies for improvement of pulmonary hemodynamics and gas exchange in sepsis and severe pulmonary hypertension]
Zeitschrift für Kardiologie 2000;89(6):477-84.
2000: Günther A; Mosavi P; Ruppert C; Heinemann S; Temmesfeld B; Velcovsky H G; Morr H; Grimminger F; Walmrath D; Seeger W
Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease.
Thrombosis and haemostasis 2000;83(6):853-60.
2000: Kiss L; Schütte H; Mayer K; Grimm H; Padberg W; Seeger W; Grimminger F
Synthesis of arachidonic acid-derived lipoxygenase and cytochrome P450 products in the intact human lung vasculature.
American journal of respiratory and critical care medicine 2000;161(6):1917-23.
2000: Jörres R A; Holz O; Zachgo W; Timm P; Koschyk S; Müller B; Grimminger F; Seeger W; Kelly F J; Dunster C; Frischer T; Lubec G; Waschewski M; Niendorf A; Magnussen H
The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies.
American journal of respiratory and critical care medicine 2000;161(6):1855-61.
2000: Ermert M; Merkle M; Mootz R; Grimminger F; Seeger W; Ermert L
Endotoxin priming of the cyclooxygenase-2-thromboxane axis in isolated rat lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;278(6):L1195-203.
2000: Ermert L; Ermert M; Merkle M; Goppelt-Struebe M; Duncker H R; Grimminger F; Seeger W
Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: differential regulation in the various types of cells in the lung.
The American journal of pathology 2000;156(4):1275-87.
2000: Ermert L; Ermert M; Duncker H R; Grimminger F; Seeger W
In situ localization and regulation of thromboxane A(2) synthase in normal and LPS-primed lungs.
American journal of physiology. Lung cellular and molecular physiology 2000;278(4):L744-53.
2000: Olschewski H; Ghofrani H A; Walmrath D; Schermuly R; Temmesfeld-Wollbrück B; Grimminger F; Seeger W
[Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to pulmonary fibrosis]
Pneumologie (Stuttgart, Germany) 2000;54(3):133-42.
2000: Günther A; Mosavi P; Heinemann S; Ruppert C; Muth H; Markart P; Grimminger F; Walmrath D; Temmesfeld-Wollbrück B; Seeger W
Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):454-62.
2000: Grimminger F; Mayer K; Kiss L; Walmrath D; Seeger W
PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L268-75.
2000: Schermuly R T; Roehl A; Weissmann N; Ghofrani H A; Schudt C; Tenor H; Grimminger F; Seeger W; Walmrath D
Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.
The Journal of pharmacology and experimental therapeutics 2000;292(2):512-20.
2000: Schermuly R T; Günther A; Weissmann N; Ghofrani H A; Seeger W; Grimminger F; Walmrath D
Differential impact of ultrasonically nebulized versus tracheal-instilled surfactant on ventilation-perfusion (VA/Q) mismatch in a model of acute lung injury.
American journal of respiratory and critical care medicine 2000;161(1):152-9.
2000: Sibelius U; Grandel U; Buerke M; Mueller D; Kiss L; Kraemer H J; Braun-Dullaeus R; Haberbosch W; Seeger W; Grimminger F
Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation.
Circulation 2000;101(1):78-85.
2000: Rosseau S; Selhorst J; Wiechmann K; Leissner K; Maus U; Mayer K; Grimminger F; Seeger W; Lohmeyer J
Monocyte migration through the alveolar epithelial barrier: adhesion molecule mechanisms and impact of chemokines.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):427-35.
1999: Günther A; Markart P; Kalinowski M; Ruppert C; Grimminger F; Seeger W
Cleavage of surfactant-incorporating fibrin by different fibrinolytic agents. Kinetics of lysis and rescue of surface activity.
American journal of respiratory cell and molecular biology 1999;21(6):738-45.
1999: Schermuly R T; Ghofrani H A; Enke B; Weissmann N; Grimminger F; Seeger W; Schudt C; Walmrath D
Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1500-6.
1999: Rosseau S; Hammerl P; Maus U; Günther A; Seeger W; Grimminger F; Lohmeyer J
Surfactant protein A down-regulates proinflammatory cytokine production evoked by Candida albicans in human alveolar macrophages and monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4495-502.
1999: Hermle G; Schütte H; Walmrath D; Geiger K; Seeger W; Grimminger F
Ventilation-perfusion mismatch after lung ischemia-reperfusion. Protective effect of nitric oxide.
American journal of respiratory and critical care medicine 1999;160(4):1179-87.
1999: Günther A; Schmidt R; Nix F; Yabut-Perez M; Guth C; Rosseau S; Siebert C; Grimminger F; Morr H; Velcovsky H G; Seeger W
Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(3):565-73.
1999: Rose F; Zwick K; Ghofrani H A; Sibelius U; Seeger W; Walmrath D; Grimminger F
Prostacyclin enhances stretch-induced surfactant secretion in alveolar epithelial type II cells.
American journal of respiratory and critical care medicine 1999;160(3):846-51.
1999: Olschewski H; Ghofrani H A; Walmrath D; Schermuly R; Temmesfeld-Wollbruck B; Grimminger F; Seeger W
Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.
American journal of respiratory and critical care medicine 1999;160(2):600-7.
1999: Grimminger F; Olschewski H; Seeger W
[Vasotropic therapy and artificial respiration for pulmonary hypertension]
Der Internist 1999;40(7):747-55.
1999: Olschewski H; Seeger W; Grimminger F
[Physiology and physiopathology of the pulmonary circulation]
Der Internist 1999;40(7):696-709.
1999: Lohmeyer J; Friedrich J; Grimminger F; Maus U; Tenter R; Morr H; Velcovsky H G; Seeger W; Rosseau S
Expression of mucosa-related integrin alphaEbeta7 on alveolar T cells in interstitial lung diseases.
Clinical and experimental immunology 1999;116(2):340-6.
1999: Braun-Dullaeus R C; Feussner M; Walker G; Hopmann H; Kraemer H J; Grimminger F; Tillmanns H; Haberbosch W
Cyclosporine-induced coronary artery constriction--dissociation between thromboxane release and coronary vasospasm.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1999;18(4):328-35.
1999: Sibelius U; Schulz E C; Rose F; Hattar K; Jacobs T; Weiss S; Chakraborty T; Seeger W; Grimminger F
Role of Listeria monocytogenes exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C in activation of human neutrophils.
Infection and immunity 1999;67(3):1125-30.
1999: Maus U; Rosseau S; Mandrakas N; Schlingensiepen R; Maus R; Muth H; Grimminger F; Seeger W; Lohmeyer J
Cationic lipids employed for antisense oligodeoxynucleotide transport may inhibit vascular cell adhesion molecule-1 expression in human endothelial cells: a word of caution.
Antisense & nucleic acid drug development 1999;9(1):71-80.
1999: Weissmann N; Voswinckel R; Hardebusch T; Rosseau S; Ghofrani H A; Schermuly R; Seeger W; Grimminger F
Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction.
The American journal of physiology 1999;276(1 Pt 1):L90-5.
1999: Rose F; Kürth-Landwehr C; Sibelius U; Reuner K H; Aktories K; Seeger W; Grimminger F
Role of actin depolymerization in the surfactant secretory response of alveolar epithelial type II cells.
American journal of respiratory and critical care medicine 1999;159(1):206-12.
1998: Grimm H; Grimminger F; Korom S; Seeger W
Use of fish oil to prevent graft rejection.
The Proceedings of the Nutrition Society 1998;57(4):577-85.
1998: Fink L; Seeger W; Ermert L; Hänze J; Stahl U; Grimminger F; Kummer W; Bohle R M
Real-time quantitative RT-PCR after laser-assisted cell picking.
Nature medicine 1998;4(11):1329-33.
1998: Weissmann N; Seeger W; Conzen J; Kiss L; Grimminger F
Effects of arachidonic acid metabolism on hypoxic vasoconstriction in rabbit lungs.
European journal of pharmacology 1998;356(2-3):231-7.
1998: Ermert L; Ermert M; Althoff A; Merkle M; Grimminger F; Seeger W
Vasoregulatory prostanoid generation proceeds via cyclooxygenase-2 in noninflamed rat lungs.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1309-14.
1998: Kiss L; Bieniek E; Weissmann N; Schutte H; Sibelius U; Gunther A; Bier J; Mayer K; Henneking K; Padberg W; Grimm H; Seeger W; Grimminger F
Simultaneous analysis of 4- and 5-series lipoxygenase and cytochrome P450 products from different biological sources by reversed-phase high-performance liquid chromatographic technique.
Analytical biochemistry 1998;261(1):16-28.
1998: Olschewski H; Ghofrani H A; Walmrath D; Temmesfeld-Wollbrück B; Grimminger F; Seeger W
Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost.
Intensive care medicine 1998;24(6):631-4.
1998: Weissmann N; Grimminger F; Voswinckel R; Conzen J; Seeger W
Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs.
The American journal of physiology 1998;274(5 Pt 1):L721-7.
1998: Temmesfeld-Wollbrück B; Szalay A; Mayer K; Olschewski H; Seeger W; Grimminger F
Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine.
American journal of respiratory and critical care medicine 1998;157(5 Pt 1):1586-92.
1998: Mayser P; Mrowietz U; Arenberger P; Bartak P; Buchvald J; Christophers E; Jablonska S; Salmhofer W; Schill W B; Krämer H J; Schlotzer E; Mayer K; Seeger W; Grimminger F
Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial.
Journal of the American Academy of Dermatology 1998;38(4):539-47.
1998: Ermert L; Ermert M; Goppelt-Struebe M; Walmrath D; Grimminger F; Steudel W; Ghofrani H A; Homberger C; Duncker H; Seeger W
Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs.
American journal of respiratory cell and molecular biology 1998;18(4):479-88.
1998: Mayer K; Seeger W; Grimminger F
Clinical use of lipids to control inflammatory disease.
Current opinion in clinical nutrition and metabolic care 1998;1(2):179-84.
1998: Schütte H; Mayer K; Gessler T; Rühl M; Schlaudraff J; Burger H; Seeger W; Grimminger F
Nitric oxide biosynthesis in an exotoxin-induced septic lung model: role of cNOS and impact on pulmonary hemodynamics.
American journal of respiratory and critical care medicine 1998;157(2):498-504.
1998: Sibelius U; Hattar K; Schenkel A; Noll T; Csernok E; Gross W L; Mayet W J; Piper H M; Seeger W; Grimminger F
Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response.
The Journal of experimental medicine 1998;187(4):497-503.
1998: Olschewski H; Walmrath D; Schermuly R; Ghofrani H A; Grimminger F; Seeger W
[Prostacyclin and iloprost in aerosol form in severe pulmonary hypertension]
Pneumologie (Stuttgart, Germany) 1998;52(1):3-7.
1998: Schütte H; Hermle G; Seeger W; Grimminger F
Vascular distension and continued ventilation are protective in lung ischemia/reperfusion.
American journal of respiratory and critical care medicine 1998;157(1):171-7.
1997: Schütte H; Rosseau S; Czymek R; Ermert L; Walmrath D; Krämer H J; Seeger W; Grimminger F
Synergism between endotoxin priming and exotoxin challenge in provoking severe vascular leakage in rabbit lungs.
American journal of respiratory and critical care medicine 1997;156(3 Pt 1):819-24.
1997: Schermuly R; Schmehl T; Günther A; Grimminger F; Seeger W; Walmrath D
Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury. Impact on gas exchange.
American journal of respiratory and critical care medicine 1997;156(2 Pt 1):445-53.
1997: Schütte H; Grimminger F; Otterbein J; Spriestersbach R; Mayer K; Walmrath D; Seeger W
Efficiency of aerosolized nitric oxide donor drugs to achieve sustained pulmonary vasodilation.
The Journal of pharmacology and experimental therapeutics 1997;282(2):985-94.
1997: Grimminger F; Rose F; Sibelius U; Meinhardt M; Pötzsch B; Spriestersbach R; Bhakdi S; Suttorp N; Seeger W
Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1909-16.
1997: Grimminger F; Mayer K; Seeger W
[Is there a reliable immunotherapy in infection?]
Der Internist 1997;38(6):541-52.
1997: Walmrath D; Olschewski H; Grimminger F; Seeger W
[NO and alternative inhalational therapy approaches in pulmonary hypertension]
Der Internist 1997;38(5):453-60.
1997: Walmrath D; Schermuly R; Pilch J; Grimminger F; Seeger W
Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(5):1084-92.
1997: Temmesfeld-Wollbrück B; Szalay A; Olschewski H; Grimminger F; Seeger W
Advantage of buffered solutions or automated capnometry in air-filled balloons for use in gastric tonometry.
Intensive care medicine 1997;23(4):423-7.
1997: Grimminger F; Mayer K; Kiss L; Wahn H; Walmrath D; Seeger W
Synthesis of 4- and 5-series leukotrienes in the lung microvasculature challenged with Escherichia coli hemolysin: critical dependence on exogenous free fatty acid supply.
American journal of respiratory cell and molecular biology 1997;16(3):317-24.
1997: Ermert L; Duncker H R; Brückner H; Grimminger F; Hansen T; Rössig R; Aktories K; Seeger W
Ultrastructural changes of lung capillary endothelium in response to botulinum C2 toxin.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;82(2):382-8.
1997: Grimminger F; Wahn H; Mayer K; Kiss L; Walmrath D; Seeger W
Impact of arachidonic versus eicosapentaenoic acid on exotonin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation.
American journal of respiratory and critical care medicine 1997;155(2):513-9.
1997: Nowak D; Jörres R; Martinez-Müller L; Grimminger F; Seeger W; Koops F; Magnussen H
Effect of 3 hours of passive smoke exposure in the evening on inflammatory markers in bronchoalveolar and nasal lavage fluid in subjects with mild asthma.
International archives of occupational and environmental health 1997;70(2):85-93.
1996: Sibelius U; Chakraborty T; Krögel B; Wolf J; Rose F; Schmidt R; Wehland J; Seeger W; Grimminger F
The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):4055-60.
1996: Krämer H J; Stevens J; Grimminger F; Seeger W
Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation.
Biochemical pharmacology 1996;52(8):1211-7.
1996: Grimminger F; Hattar K; Papavassilis C; Temmesfeld B; Csernok E; Gross W L; Seeger W; Sibelius U
Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation.
The Journal of experimental medicine 1996;184(4):1567-72.
1996: Schütte H; Lohmeyer J; Rosseau S; Ziegler S; Siebert C; Kielisch H; Pralle H; Grimminger F; Morr H; Seeger W
Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(9):1858-67.
1996: Walmrath D; Ghofrani H A; Grimminger F; Seeger W
Synergism of alveolar endotoxin "priming" and intravascular exotoxin challenge in lung injury.
American journal of respiratory and critical care medicine 1996;154(2 Pt 1):460-8.
1996: Walmrath D; Günther A; Ghofrani H A; Schermuly R; Schneider T; Grimminger F; Seeger W
Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis.
American journal of respiratory and critical care medicine 1996;154(1):57-62.
1996: Reinhart K; Wiegand-Löhnert C; Grimminger F; Kaul M; Withington S; Treacher D; Eckart J; Willatts S; Bouza C; Krausch D; Stockenhuber F; Eiselstein J; Daum L; Kempeni J
Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study.
Critical care medicine 1996;24(5):733-42.
1996: Olschewski H; Walmrath D; Schermuly R; Ghofrani A; Grimminger F; Seeger W
Aerosolized prostacyclin and iloprost in severe pulmonary hypertension.
Annals of internal medicine 1996;124(9):820-4.
1996: Hammes H P; Weiss A; Führer D; Krämer H J; Papavassilis C; Grimminger F
Acceleration of experimental diabetic retinopathy in the rat by omega-3 fatty acids.
Diabetologia 1996;39(3):251-5.
1996: Walmrath D; Schneider T; Schermuly R; Olschewski H; Grimminger F; Seeger W
Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 1996;153(3):991-6.
1996: Sibelius U; Rose F; Chakraborty T; Darji A; Wehland J; Weiss S; Seeger W; Grimminger F
Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.
Infection and immunity 1996;64(2):674-6.
1996: Ghofrani H A; Rosseau S; Walmrath D; Kaddus W; Kramer A; Grimminger F; Lohmeyer J; Seeger W
Compartmentalized lung cytokine release in response to intravascular and alveolar endotoxin challenge.
The American journal of physiology 1996;270(1 Pt 1):L62-8.
1996: Grimminger F; Grimm H; Führer D; Papavassilis C; Lindemann G; Blecher C; Mayer K; Tabesch F; Krämer H J; Stevens J; Seeger W
Omega-3 lipid infusion in a heart allotransplant model. Shift in fatty acid and lipid mediator profiles and prolongation of transplant survival.
Circulation 1996;93(2):365-71.
1996: Günther A; Siebert C; Schmidt R; Ziegler S; Grimminger F; Yabut M; Temmesfeld B; Walmrath D; Morr H; Seeger W
Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema.
American journal of respiratory and critical care medicine 1996;153(1):176-84.
1996: Bhakdi S; Walev I; Jonas D; Palmer M; Weller U; Suttorp N; Grimminger F; Seeger W
Pathogenesis of sepsis syndrome: possible relevance of pore-forming bacterial toxins.
Current topics in microbiology and immunology 1996;216():101-18.
1995: Seeger W; Walmrath D; Grimminger F
[New supportive therapy measures in acute lung failure]
Der Internist 1995;36(12):1139-49.
1995: Seeger W; Walmrath D; Grimminger F
[ARDS. Intensive therapy of acute lung failure]
Der Internist 1995;36(8):785-801.
1995: Seeger W; Hansen T; Rössig R; Schmehl T; Schütte H; Krämer H J; Walmrath D; Weissmann N; Grimminger F; Suttorp N
Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability--effect of adenylate cyclase stimulation and phosphodiesterase inhibition.
Microvascular research 1995;50(1):1-17.
1995: Grimminger F; Wahn H; Kramer H J; Stevens J; Mayer K; Walmrath D; Seeger W
Differential influence of arachidonic vs. eicosapentaenoic acid on experimental pulmonary hypertension.
The American journal of physiology 1995;268(6 Pt 2):H2252-9.
1995: Ermert L; Brückner H; Walmrath D; Grimminger F; Aktories K; Suttorp N; Duncker H R; Seeger W
Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs.
The American journal of physiology 1995;268(5 Pt 1):L753-61.
1995: Grimminger F; Weissmann N; Spriestersbach R; Becker E; Rosseau S; Seeger W
Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs.
The American journal of physiology 1995;268(5 Pt 1):L747-52.
1995: Weissmann N; Grimminger F; Walmrath D; Seeger W
Hypoxic vasoconstriction in buffer-perfused rabbit lungs.
Respiration physiology 1995;100(2):159-69.
1995: Grimm H; Tibell A; Norrlind B; Schott J; Bohle R M; Papavassilis C; Führer D; Mayer K; Grimminger F
[Immunosuppressive effect of parenteral fat emulsions in defined immunostimulation]
Infusionstherapie und Transfusionsmedizin 1995;22(2):110-6.
1995: Grimminger F; Spriestersbach R; Weissmann N; Walmrath D; Seeger W
Nitric oxide generation and hypoxic vasoconstriction in buffer-perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(4):1509-15.
1995: Spriestersbach R; Grimminger F; Weissmann N; Walmrath D; Seeger W
On-line measurement of nitric oxide generation in buffer-perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(4):1502-8.
1995: Walmrath D; Schneider T; Pilch J; Schermuly R; Grimminger F; Seeger W
Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis.
American journal of respiratory and critical care medicine 1995;151(3 Pt 1):724-30.
1995: Jörres R; Nowak D; Grimminger F; Seeger W; Oldigs M; Magnussen H
The effect of 1 ppm nitrogen dioxide on bronchoalveolar lavage cells and inflammatory mediators in normal and asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(3):416-24.
1995: Grimminger F; Mayser P
Lipid mediators, free fatty acids and psoriasis.
Prostaglandins, leukotrienes, and essential fatty acids 1995;52(1):1-15.
1995: Temmesfeld-Wollbrück B; Walmrath D; Grimminger F; Seeger W
Prevention and therapy of the adult respiratory distress syndrome.
Lung 1995;173(3):139-64.
1994: Walmrath D; Ghofrani H A; Rosseau S; Schütte H; Cramer A; Kaddus W; Grimminger F; Bhakdi S; Seeger W
Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin.
The Journal of experimental medicine 1994;180(4):1437-43.
1994: Bhakdi S; Grimminger F; Suttorp N; Walmrath D; Seeger W
Proteinaceous bacterial toxins and pathogenesis of sepsis syndrome and septic shock: the unknown connection.
Medical microbiology and immunology 1994;183(3):119-44.
1994: Walmrath D; Pilch J; Scharmann M; Grimminger F; Seeger W
Severe VA/Q mismatch in perfused lungs evoked by sequential challenge with endotoxin and E. coli hemolysin.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(3):1020-30.
1994: Seeger W; Walmrath D; Grimminger F; Rosseau S; Schütte H; Krämer H J; Ermert L; Kiss L
Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs.
Methods in enzymology 1994;233():549-84.
1993: Grimminger F; Führer D; Papavassilis C; Schlotzer E; Mayer K; Heuer K U; Kiss L; Walmrath D; Piberhofer S; Lübbecke F
Influence of intravenous n-3 lipid supplementation on fatty acid profiles and lipid mediator generation in a patient with severe ulcerative colitis.
European journal of clinical investigation 1993;23(11):706-15.
1993: Walmrath D; Griebner M; Kolb B; Grimminger F; Galanos C; Schade U; Seeger W
Endotoxin primes perfused rabbit lungs for enhanced vasoconstrictor response to staphylococcal alpha-toxin.
The American review of respiratory disease 1993;148(5):1179-86.
1993: Grimminger F; Mayer K; Krämer H J; Stevens J; Walmrath D; Seeger W
Differential vasoconstrictor potencies of free fatty acids in the lung vasculature: 2-versus 3-series prostanoid generation.
The Journal of pharmacology and experimental therapeutics 1993;267(1):259-65.
1993: Walmrath D; Schneider T; Pilch J; Grimminger F; Seeger W
Aerosolised prostacyclin in adult respiratory distress syndrome.
Lancet 1993;342(8877):961-2.
1993: Grimminger F; Mayser P; Papavassilis C; Thomas M; Schlotzer E; Heuer K U; Führer D; Hinsch K D; Walmrath D; Schill W B
A double-blind, randomized, placebo-controlled trial of n-3 fatty acid based lipid infusion in acute, extended guttate psoriasis. Rapid improvement of clinical manifestations and changes in neutrophil leukotriene profile.
The Clinical investigator 1993;71(8):634-43.
1993: Suttorp N; Fuhrmann M; Tannert-Otto S; Grimminger F; Bhadki S
Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells.
The Journal of experimental medicine 1993;178(1):337-41.
1993: Walmrath D; Scharmann M; König R; Pilch J; Grimminger F; Seeger W
Staphylococcal alpha-toxin induced ventilation-perfusion mismatch in isolated blood-free perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(4):1972-80.
1993: Seeger W; Günther A; Walmrath H D; Grimminger F; Lasch H G
Alveolar surfactant and adult respiratory distress syndrome. Pathogenetic role and therapeutic prospects.
The Clinical investigator 1993;71(3):177-90.
1993: Nowak D; Grimminger F; Jörres R; Oldigs M; Rabe K F; Seeger W; Magnussen H
Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(3):405-12.
1992: Seeger W; Grimminger F; Walmrath D
[ARDS: possible role of bacterial exotoxin]
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 1992;27(5):310-4.
1992: Grimminger F; Dürr U; Seeger W
Ligand-operated synthesis of 4-series and 5-series leukotrienes in human neutrophils: critical dependence on exogenous free fatty acid supply.
Molecular pharmacology 1992;41(4):757-66.
1992: Ermert L; Rousseau S; Schütte H; Birkemeyer R G; Grimminger F; Bhakdi S; Duncker H R; Seeger W
Induction of severe vascular leakage by low doses of Escherichia coli hemolysin in perfused rabbit lungs.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):362-9.
1992: Grimminger F; von Kürten I; Walmrath D; Seeger W
Type II alveolar epithelial eicosanoid metabolism: predominance of cyclooxygenase pathways and transcellular lipoxygenase metabolism in co-culture with neutrophils.
American journal of respiratory cell and molecular biology 1992;6(1):9-16.
1992: Walmrath D; König R; Ernst C; Brückner H; Grimminger F; Seeger W
Ventilation-perfusion relationships in isolated blood-free perfused rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(1):374-82.
1991: Walmrath D; Schneider U; Kreusler B; Grimminger F; Ennis M; Seeger W
Intravascular anti-IgE challenge in perfused lungs: mediator release and vascular pressor response.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(6):2499-506.
1991: Grimminger F; Sibelius U; Bhakdi S; Suttorp N; Seeger W
Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils.
The Journal of clinical investigation 1991;88(5):1531-9.
1991: Schütte H; Rosseau S; Walmrath D; Grimminger F; Ernst C; Seeger W
Neutrophil passage through isolated perfused rabbit lungs.
The American journal of physiology 1991;261(4 Pt 2):H1317-23.
1991: Grimminger F; Sibelius U; Aktories K; Suttorp N; Seeger W
Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils.
Molecular pharmacology 1991;40(4):563-71.
1991: Grimminger F; Sibelius U; Aktories K; Just I; Seeger W
Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction.
The Journal of biological chemistry 1991;266(29):19276-82.
1991: Grimminger F; Scholz C; Bhakdi S; Seeger W
Subhemolytic doses of Escherichia coli hemolysin evoke large quantities of lipoxygenase products in human neutrophils.
The Journal of biological chemistry 1991;266(22):14262-9.
1991: Grimminger F; Sibelius U; Seeger W
Amplification of LTB4 generation in AM-PMN cocultures: transcellular 5-lipoxygenase metabolism.
The American journal of physiology 1991;261(2 Pt 1):L195-203.
1991: Suttorp N; Polley M; Seybold J; Schnittler H; Seeger W; Grimminger F; Aktories K
Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro.
The Journal of clinical investigation 1991;87(5):1575-84.
1991: Seeger W; Obernitz R; Thomas M; Walmrath D; Suttorn N; Holland I B; Grimminger F; Eberspächer B; Hugo F; Bhakdi S
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
The American review of respiratory disease 1991;143(4 Pt 1):797-805.
1991: Grimminger F; Kreusler B; Schneider U; von Witzleben E; Walmrath D; Neppert J; Seeger W
Human leukoagglutinating antibody evokes cooperative leukotriene synthesis in pulmonary microvasculature. Model of transfusion-related acute lung injury.
Circulation research 1991;68(2):503-12.
1991: Grimminger F; Walmrath D; Walter H; Lutz F; Seeger W
Induction of vascular injury by Pseudomonas aeruginosa cytotoxin in rabbit lungs is associated with the generation of different leukotrienes and hydroxyeicosatetraenoic acids.
The Journal of infectious diseases 1991;163(2):362-70.
1991: Seeger W; Grimminger F
Leukotrienes and ARDS.
Intensive care medicine 1991;17(1):65-6.
1991: Seeger W; Grimminger F; Barden M; Becker G; Lohmeyer J; Heinrich D; Lasch H G
Omega-oxidized leukotriene B4 detected in the broncho-alveolar lavage fluid of patients with non-cardiogenic pulmonary edema, but not in those with cardiogenic edema.
Intensive care medicine 1991;17(1):1-6.
1990: Seeger W; Schneider U; Kreusler B; von Witzleben E; Walmrath D; Grimminger F; Neppert J
Reproduction of transfusion-related acute lung injury in an ex vivo lung model.
Blood 1990;76(7):1438-44.
1990: Grimminger F; Thomas M; Obernitz R; Walmrath D; Bhakdi S; Seeger W
Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature.
The Journal of experimental medicine 1990;172(4):1115-25.
1990: Grimminger F; Walmrath D; Birkemeyer R G; Bhakdi S; Seeger W
Leukotriene and hydroxyeicosatetraenoic acid generation elicited by low doses of Escherichia coli hemolysin in rabbit lungs.
Infection and immunity 1990;58(8):2659-63.
1990: Grimminger F; Kreusler B; Schneider U; Becker G; Seeger W
Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1866-72.
1990: Seeger W; Grimminger F
[The role of arachidonic acid metabolites in the pathogenesis of bronchial asthma]
Verhandlungen der Deutschen Gesellschaft für Innere Medizin 1990;96():685-93.
1988: Grimminger F; Menger M; Becker G; Seeger W
Potentiation of leukotriene production following sequestration of neutrophils in isolated lungs: indirect evidence for intercellular leukotriene A4 transfer.
Blood 1988;72(5):1687-92.
1988: Grimminger F; Becker G; Seeger W
High yield enzymatic conversion of intravascular leukotriene A4 in blood-free perfused lungs.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(7):2431-6.
1987: Seeger W; Menger M; Walmrath D; Becker G; Grimminger F; Neuhof H
Arachidonic acid lipoxygenase pathways and increased vascular permeability in isolated rabbit lungs.
The American review of respiratory disease 1987;136(4):964-72.

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