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Alan Buckpitt

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Nathalie T Pham; William T Jewell; Dexter Morin; Alan R Buckpitt
Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry.
Charles G Plopper; Edward S Schelegle; Brian K Tarkington; Nancy K Tyler; Laura S Van Winkle; Rong Wu; Mark V Avdalovic; Alan R Buckpitt; S Davis; Michael J Evans; Michelle V Fanucchi; Laurel J Gershwin; Jesse P Joad; W L Lasley; Lisa A Miller; Susan J Nishio; Kent E Pinkerton; Dallas M Hyde
Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma.
Nathalie T Pham; William T Jewell; A Daniel Jones; Dexter Morin; Alan R Buckpitt
Characterization of model peptide adducts with reactive metabolites of naphthalene by mass spectrometry.

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All Publications

2012: Nathalie T Pham; William T Jewell; Dexter Morin; Alan R Buckpitt
Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry.
Chemico-biological interactions 2012;199(2):120-8.
2012: Charles G Plopper; Edward S Schelegle; Brian K Tarkington; Nancy K Tyler; Laura S Van Winkle; Rong Wu; Mark V Avdalovic; Alan R Buckpitt; S Davis; Michael J Evans; Michelle V Fanucchi; Laurel J Gershwin; Jesse P Joad; W L Lasley; Lisa A Miller; Susan J Nishio; Kent E Pinkerton; Dallas M Hyde
Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2012;42(7):1104-18.
2012: Nathalie T Pham; William T Jewell; A Daniel Jones; Dexter Morin; Alan R Buckpitt
Characterization of model peptide adducts with reactive metabolites of naphthalene by mass spectrometry.
PloS one 2012;7(8):e42053.
2010: Page C Spiess; Dexter Morin; Chase R Williams; Alan R Buckpitt
Protein thiol oxidation in murine airway epithelial cells in response to naphthalene or diethyl maleate.
American journal of respiratory cell and molecular biology 2010;43(3):316-25.
2010: Christina DeStefano-Shields; Dexter Morin; Alan R Buckpitt
Formation of covalently bound protein adducts from the cytotoxicant naphthalene in nasal epithelium: species comparisons.
Environmental health perspectives 2010;118(5):647-52.
2009: John B Morris; Alan R Buckpitt
Upper respiratory tract uptake of naphthalene.
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):383-91.
2009: Ching Yu Lin; Asa M Wheelock; Dexter Morin; R Michael Baldwin; Myong Gong Lee; Aysha Taff; Charles G Plopper; Alan R Buckpitt; Arlean Rohde
Toxicity and metabolism of methylnaphthalenes: comparison with naphthalene and 1-nitronaphthalene.
Toxicology 2009;260(1-3):16-27.
2009: H K DiMaio Knych; C DeStefano Shields; Alan R Buckpitt; Scott D Stanley
Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization.
Archives of biochemistry and biophysics 2009;485(1):49-55.
2008: Page C Spiess; Dexter Morin; William T Jewell; Alan R Buckpitt
Measurement of protein sulfhydryls in response to cellular oxidative stress using gel electrophoresis and multiplexed fluorescent imaging analysis.
Chemical research in toxicology 2008;21(5):1074-85.
2008: Yong Chan Lee; Chun-Yu Chuang; Pak-Kei Lee; Jin-Soo Lee; Richart W Harper; Alan R Buckpitt; Reen Wu; Karen Oslund
TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2008;294(5):L921-31.
2008: Christophe Morisseau; John William Newman; Craig E Wheelock; Thomas Hill Iii; Dexter Morin; Alan R Buckpitt; Bruce D Hammock
Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase.
Chemical research in toxicology 2008;21(4):951-7.
2007: Eleonora Napoli; Dexter Morin; Rita Bernhardt; Alan R Buckpitt; Gino Cortopassi
Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells.
Biochimica et biophysica acta 2007;1772(7):773-80.
2007: Charles G Plopper; Suzette M Smiley-Jewell; Lisa A Miller; Michelle V Fanucchi; Michael J Evans; Alan R Buckpitt; Mark V Avdalovic; Laurel J Gershwin; Jesse P Joad; Radhika Kajekar; Shawnessy Larson; Kent E Pinkerton; Laura S Van Winkle; Edward S Schelegle; Emily M Pieczarka; Reen Wu; Dallas M Hyde
Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?
Toxicologic pathology 2007;35(1):97-110.
2006: Asa M Wheelock; Dexter Morin; Matthew Bartosiewicz; Alan R Buckpitt
Use of a fluorescent internal protein standard to achieve quantitative two-dimensional gel electrophoresis.
Proteomics 2006;6(5):1385-98.
2006: Ching Yu Lin; Bridget C Boland; Young Jin Lee; Michelle R Salemi; Dexter Morin; Lisa A Miller; Charles G Plopper; Alan R Buckpitt
Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques.
Proteomics 2006;6(3):972-82.
2005: Robert A Schoenfeld; Eleonora Napoli; Alice Wong; Shan Zhan; Laurence Reutenauer; Dexter Morin; Alan R Buckpitt; Franco Taroni; Bo Lonnerdal; Michael Ristow; Hélène Puccio; Gino Cortopassi
Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells.
Human molecular genetics 2005;14(24):3787-99.
2005: Asa M Wheelock; Alan R Buckpitt
Software-induced variance in two-dimensional gel electrophoresis image analysis.
Electrophoresis 2005;26(23):4508-20.
2005: Margaret A Isbell; Dexter Morin; Bridget C Boland; Alan R Buckpitt; Michelle R Salemi; Jack Presley
Identification of proteins adducted by reactive naphthalene metabolites in vitro.
Proteomics 2005;5(16):4197-204.
2005: Asa M Wheelock; Bridget C Boland; Margaret A Isbell; Dexter Morin; Teresa Wegesser; Charles G Plopper; Alan R Buckpitt
In vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene in rat lung.
American journal of respiratory cell and molecular biology 2005;33(2):130-7.
2005: Myong Gyong Lee; Andrew J Phimister; Dexter Morin; Alan R Buckpitt; Charles G Plopper
In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation.
The Journal of pharmacology and experimental therapeutics 2005;314(1):103-10.
2005: Ching Yu Lin; Margaret A Isbell; Dexter Morin; Bridget C Boland; Michelle R Salemi; William T Jewell; Alison J Weir; Michelle V Fanucchi; Gregory L Baker; Charles G Plopper; Alan R Buckpitt
Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs lung microsomes.
Chemical research in toxicology 2005;18(5):802-13.
2005: R Michael Baldwin; Michael A Shultz; Alan R Buckpitt
Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4.
The Journal of pharmacology and experimental therapeutics 2005;312(2):857-65.
2005: Andrew J Phimister; H T Nagasawa; Alan R Buckpitt; Charles G Plopper
Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: roles for glutathione depletion in adduct formation and cell injury.
Journal of biochemical and molecular toxicology 2005;19(1):42-51.
2004: Andrew J Phimister; M G Lee; Dexter Morin; Alan R Buckpitt; Charles G Plopper
Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(1):268-78.
2004: Bridget C Boland; Ching Yu Lin; Dexter Morin; Lisa Miller; Charles G Plopper; Alan R Buckpitt
Site-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques.
The Journal of pharmacology and experimental therapeutics 2004;310(2):546-54.
2004: R Michael Baldwin; William T Jewell; Michelle V Fanucchi; Charles G Plopper; Alan R Buckpitt
Comparison of pulmonary/nasal CYP2F expression levels in rodents and rhesus macaque.
The Journal of pharmacology and experimental therapeutics 2004;309(1):127-36.
2004: Michael A Shultz; Lu Zhang; Yi-Zhong Gu; Gregory L Baker; Michelle V Fannuchi; Allan M Padua; William A Gurske; Dexter Morin; Sharron G Penn; Stevan B Jovanovich; Charles G Plopper; Alan R Buckpitt
Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development.
American journal of respiratory cell and molecular biology 2004;30(3):296-310.
2004: Asa M Wheelock; Lu Zhang; Mai-Uyen T Tran; Dexter Morin; Sharron G Penn; Alan R Buckpitt; Charles G Plopper
Isolation of rodent airway epithelial cell proteins facilitates in vivo proteomics studies of lung toxicity.
American journal of physiology. Lung cellular and molecular physiology 2004;286(2):L399-410.
2004: Gregory L Baker; Michael A Shultz; Michelle V Fanucchi; Dexter M Morin; Alan R Buckpitt; Charles G Plopper
Assessing gene expression in lung subcompartments utilizing in situ RNA preservation.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(1):135-41.
2003: Michael A Shultz; Katherine Watt Chan; Dexter Morin; Alan R Buckpitt
Measurement of glutathione conjugates.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2003;Chapter 6():Unit6.8.
2002: Alan R Buckpitt; Bridget C Boland; Margaret A Isbell; Dexter Morin; Michael A Shultz; R Baldwin; K Chan; A Karlsson; C Lin; A Taff; J West; Michelle V Fanucchi; Laura S Van Winkle; Charles G Plopper
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
Drug metabolism reviews 2002;34(4):791-820.
2002: Shri N Giri; Qingjian Wang; Yan Xie; Jozsef Lango; Dexter Morin; Solomon B Margolin; Alan R Buckpitt
Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration.
Biopharmaceutics & drug disposition 2002;23(5):203-11.
2002: Jay A A West; Kurt J Williams; Elina Toskala; Susan J Nishio; Chad A Fleschner; Henry Jay Forman; Alan R Buckpitt; Charles G Plopper
Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool.
The American journal of pathology 2002;160(3):1115-27.
2002: Gwyn Pakenham; Jozsef Lango; Michael Buonarati; Dexter Morin; Alan R Buckpitt
Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(3):247-53.
2001: Jay A A West; G Pakehham; Dexter Morin; Chad A Fleschner; Alan R Buckpitt; Charles G Plopper
Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats.
Toxicology and applied pharmacology 2001;173(2):114-9.
2001: Matthew Bartosiewicz; D Jenkins; Sharron G Penn; J Emery; Alan R Buckpitt
Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants.
The Journal of pharmacology and experimental therapeutics 2001;297(3):895-905.
2001: Charles G Plopper; Alan R Buckpitt; M Evans; Laura S Van Winkle; Michelle V Fanucchi; Suzette M Smiley-Jewell; Jeffrey Lakritz; J West; G Lawson; Renee C Paige; Lisa Miller; D Hyde
Factors modulating the epithelial response to toxicants in tracheobronchial airways.
Toxicology 2001;160(1-3):173-80.
2001: Charles G Plopper; Laura S Van Winkle; Michelle V Fanucchi; S R Malburg; S J Nishio; A Chang; Alan R Buckpitt
Early events in naphthalene-induced acute Clara cell toxicity. II. Comparison of glutathione depletion and histopathology by airway location.
American journal of respiratory cell and molecular biology 2001;24(3):272-81.
2001: Michael A Shultz; Dexter Morin; A M Chang; Alan R Buckpitt
Metabolic capabilities of CYP2F2 with various pulmonary toxicants and its relative abundance in mouse lung subcompartments.
The Journal of pharmacology and experimental therapeutics 2001;296(2):510-9.
2001: Matthew Bartosiewicz; Sharron G Penn; Alan R Buckpitt
Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene.
Environmental health perspectives 2001;109(1):71-4.
2001: Edward S Schelegle; Laurel J Gershwin; Lisa A Miller; Michelle V Fanucchi; Laura S Van Winkle; J P Gerriets; William F Walby; A M Omlor; Alan R Buckpitt; Brian K Tarkington; Viviana J Wong; Jesse P Joad; Kent E Pinkerton; Reen Wu; Michael J Evans; Dallas M Hyde; Charles G Plopper
Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae).
The American journal of pathology 2001;158(1):333-41.
2000: Renee C Paige; FH Royce; Charles G Plopper; Alan R Buckpitt
Long-term exposure to ozone increases acute pulmonary centriacinar injury by 1-nitronaphthalene: I. Region-specific enzyme activity.
The Journal of pharmacology and experimental therapeutics 2000;295(3):934-41.
2000: Michelle V Fanucchi; Alan R Buckpitt; ME Murphy; D H Storms; B D Hammock; Charles G Plopper
Development of phase II xenobiotic metabolizing enzymes in differentiating murine clara cells.
Toxicology and applied pharmacology 2000;168(3):253-67.
2000: Jay A A West; Alan R Buckpitt; Charles G Plopper
Elevated airway GSH resynthesis confers protection to Clara cells from naphthalene injury in mice made tolerant by repeated exposures.
The Journal of pharmacology and experimental therapeutics 2000;294(2):516-23.
2000: Jay A A West; C H Chichester; Alan R Buckpitt; Nancy K Tyler; P Brennan; C Helton; Charles G Plopper
Heterogeneity of clara cell glutathione. A possible basis for differences in cellular responses to pulmonary cytotoxicants.
American journal of respiratory cell and molecular biology 2000;23(1):27-36.
2000: Matthew Bartosiewicz; M Trounstine; D Barker; R Johnston; Alan R Buckpitt
Development of a toxicological gene array and quantitative assessment of this technology.
Archives of biochemistry and biophysics 2000;376(1):66-73.
2000: KC Watt; Alan R Buckpitt
Species differences in the regio- and stereoselectivity of 1-nitronaphthalene metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):376-8.
2000: Jeffrey Lakritz; B S Winder; J Noorouz-Zadeh; T L Huang; Alan R Buckpitt; Bruce D Hammock; Charles G Plopper
Hepatic and pulmonary enzyme activities in horses.
American journal of veterinary research 2000;61(2):152-7.
1999: KC Watt; D M Morin; M J Kurth; R S Mercer; Charles G Plopper; Alan R Buckpitt
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
Chemical research in toxicology 1999;12(9):831-9.
1999: Michael A Shultz; Prabhakara V Choudary; Alan R Buckpitt
Role of murine cytochrome P-450 2F2 in metabolic activation of naphthalene and metabolism of other xenobiotics.
The Journal of pharmacology and experimental therapeutics 1999;290(1):281-8.
1998: Charles G Plopper; Gary E Hatch; V Wong; X Duan; Alison J Weir; Brian K Tarkington; Robert B Devlin; Susanne Becker; Alan R Buckpitt
Relationship of inhaled ozone concentration to acute tracheobronchial epithelial injury, site-specific ozone dose, and glutathione depletion in rhesus monkeys.
American journal of respiratory cell and molecular biology 1998;19(3):387-99.
1998: C Lee; KC Watt; A M Chang; Charles G Plopper; Alan R Buckpitt; Kent E Pinkerton
Site-selective differences in cytochrome P450 isoform activities. Comparison of expression in rat and rhesus monkey lung and induction in rats.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(5):396-400.
1998: KC Watt; Charles G Plopper; Alison J Weir; Brian K Tarkington; Alan R Buckpitt
Cytochrome P450 2E1 in rat tracheobronchial airways: response to ozone exposure.
Toxicology and applied pharmacology 1998;149(2):195-202.
1997: Michelle V Fanucchi; ME Murphy; Alan R Buckpitt; R M Philpot; Charles G Plopper
Pulmonary cytochrome P450 monooxygenase and Clara cell differentiation in mice.
American journal of respiratory cell and molecular biology 1997;17(3):302-14.
1997: KC Watt; Charles G Plopper; Alan R Buckpitt
Measurement of cytochrome P450 2E1 activity in rat tracheobronchial airways using high-performance liquid chromatography with electrochemical detection.
Analytical biochemistry 1997;248(1):26-30.
1997: Michelle V Fanucchi; Alan R Buckpitt; ME Murphy; Charles G Plopper
Naphthalene cytotoxicity of differentiating Clara cells in neonatal mice.
Toxicology and applied pharmacology 1997;144(1):96-104.
1997: Jeffrey Lakritz; Charles G Plopper; Alan R Buckpitt
Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples.
Analytical biochemistry 1997;247(1):63-8.
1996: A S Wilson; C D Davis; Dominic P Williams; Alan R Buckpitt; Munir Pirmohamed; B Kevin Park
Characterisation of the toxic metabolite(s) of naphthalene.
Toxicology 1996;114(3):233-42.
1996: Jeffrey Lakritz; A Chang; Alison J Weir; S Nishio; D Hyde; R Philpot; Alan R Buckpitt; Charles G Plopper
Cellular and metabolic basis of Clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1408-18.
1996: X Duan; Charles G Plopper; P Brennan; Alan R Buckpitt
Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1402-9.
1996: Laura S Van Winkle; Alan R Buckpitt; Charles G Plopper
Maintenance of differentiated murine Clara cells in microdissected airway cultures.
American journal of respiratory cell and molecular biology 1996;14(6):586-98.
1996: X Duan; Alan R Buckpitt; Kent E Pinkerton; C Ji; Charles G Plopper
Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys.
American journal of respiratory cell and molecular biology 1996;14(1):70-5.
1995: Laura S Van Winkle; Alan R Buckpitt; S J Nishio; J M Isaac; Charles G Plopper
Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice.
The American journal of physiology 1995;269(6 Pt 1):L800-18.
1995: A Gebremichael; A M Chang; Alan R Buckpitt; Charles G Plopper; Kent E Pinkerton
Postnatal development of cytochrome P4501A1 and 2B1 in rat lung and liver: effect of aged and diluted sidestream cigarette smoke.
Toxicology and applied pharmacology 1995;135(2):246-53.
1995: C M Ji; Wellington Cardoso; A Gebremichael; R M Philpot; Alan R Buckpitt; Charles G Plopper; Kent E Pinkerton
Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats.
The American journal of physiology 1995;269(3 Pt 1):L394-402.
1995: L H Overby; Alan R Buckpitt; M P Lawton; Emmanuel Atta-Asafo-Adjei; J Schulze; RM Philpot
Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog.
Archives of biochemistry and biophysics 1995;317(1):275-84.
1995: Alan R Buckpitt; A M Chang; Alison J Weir; Laura S Van Winkle; X Duan; R Philpot; Charles G Plopper
Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters.
Molecular pharmacology 1995;47(1):74-81.
1995: M Cho; C Chichester; Charles G Plopper; Alan R Buckpitt
Biochemical factors important in Clara cell selective toxicity in the lung.
Drug metabolism reviews 1995;27(1-2):369-86.
1994: Charles G Plopper; X Duan; Alan R Buckpitt; Kent E Pinkerton
Dose-dependent tolerance to ozone. IV. Site-specific elevation in antioxidant enzymes in the lungs of rats exposed for 90 days or 20 months.
Toxicology and applied pharmacology 1994;127(1):124-31.
1994: M Cho; C Chichester; Dexter Morin; Charles G Plopper; Alan R Buckpitt
Covalent interactions of reactive naphthalene metabolites with proteins.
The Journal of pharmacology and experimental therapeutics 1994;269(2):881-9.
1994: Charles G Plopper; Alison J Weir; S J Nishio; A Chang; M Voit; R M Philpot; Alan R Buckpitt
Elevated susceptibility to 4-ipomeanol cytotoxicity in immature Clara cells of neonatal rabbits.
The Journal of pharmacology and experimental therapeutics 1994;269(2):867-80.
1994: C H Chichester; Alan R Buckpitt; A Chang; Charles G Plopper
Metabolism and cytotoxicity of naphthalene and its metabolites in isolated murine Clara cells.
Molecular pharmacology 1994;45(4):664-72.
1994: J M Cheek; Alan R Buckpitt; C Li; Brian K Tarkington; Charles G Plopper
Ozone injury to alveolar epithelium in vitro does not reflect loss of antioxidant defenses.
Toxicology and applied pharmacology 1994;125(1):59-69.
1994: M Cho; R Jedrychowski; Bruce D Hammock; Alan R Buckpitt
Reactive naphthalene metabolite binding to hemoglobin and albumin.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;22(1):26-33.
1993: X Duan; Alan R Buckpitt; Charles G Plopper
Variation in antioxidant enzyme activities in anatomic subcompartments within rat and rhesus monkey lung.
Toxicology and applied pharmacology 1993;123(1):73-82.
1993: Charles G Plopper; Alison J Weir; D Morin; A Chang; R M Philpot; Alan R Buckpitt
Postnatal changes in the expression and distribution of pulmonary cytochrome P450 monooxygenases during Clara cell differentiation in rabbits.
Molecular pharmacology 1993;44(1):51-61.
1993: J D Baggot; Alan R Buckpitt; D Johnson; P Brennan; H Chung
Bioavailability and disposition kinetics of HI-6 in Beagle dogs.
Biopharmaceutics & drug disposition 1993;14(2):93-105.
1992: C G Plopper; J Macklin; S J Nishio; Dallas M Hyde; Alan R Buckpitt
Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. III. Morphometric comparison of changes in the epithelial populations of terminal bronchioles and lobar bronchi in mice, hamsters, and rats after parenteral administration of naphthalene.
Laboratory investigation; a journal of technical methods and pathology 1992;67(5):553-65.
1992: Alan R Buckpitt; M Buonarati; L B Avey; A M Chang; Dexter Morin; Charles G Plopper
Relationship of cytochrome P450 activity to Clara cell cytotoxicity. II. Comparison of stereoselectivity of naphthalene epoxidation in lung and nasal mucosa of mouse, hamster, rat and rhesus monkey.
The Journal of pharmacology and experimental therapeutics 1992;261(1):364-72.
1992: Charles G Plopper; C Suverkropp; Dexter Morin; S Nishio; Alan R Buckpitt
Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. I. Histopathologic comparison of the respiratory tract of mice, rats and hamsters after parenteral administration of naphthalene.
The Journal of pharmacology and experimental therapeutics 1992;261(1):353-63.
1992: Charles G Plopper; J St George; W Cardoso; Reen Wu; Kent E Pinkerton; Alan R Buckpitt
Development of airway epithelium. Patterns of expression for markers of differentiation.
Chest 1992;101(3 Suppl):2S-5S.
1992: J A Bond; Lance Wallace; S Osterman-Golkar; G W Lucier; Alan R Buckpitt; R F Hendersen
Assessment of exposure to pulmonary toxicants: use of biological markers.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1992;18(2):161-74.
1991: P Brennan; D Johnson; S Rider; N Cone; M Goldman; Alan R Buckpitt; H Chung
Dermal absorption of niclosamide in rats and minipigs.
Biopharmaceutics & drug disposition 1991;12(7):547-56.
1991: Charles G Plopper; A M Chang; A Pang; Alan R Buckpitt
Use of microdissected airways to define metabolism and cytotoxicity in murine bronchiolar epithelium.
Experimental lung research 1991;17(2):197-212.
1991: C H Chichester; R M Philpot; Alison J Weir; Alan R Buckpitt; Charles G Plopper
Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung.
American journal of respiratory cell and molecular biology 1991;4(2):179-86.
1991: S Kanekal; Charles G Plopper; Dexter Morin; Alan R Buckpitt
Metabolism and cytotoxicity of naphthalene oxide in the isolated perfused mouse lung.
The Journal of pharmacology and experimental therapeutics 1991;256(1):391-401.
1990: M Buonarati; A Daniel Jones; Alan R Buckpitt
In vivo metabolism of isomeric naphthalene oxide glutathione conjugates.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(2):183-9.
1990: S Kanekal; Charles G Plopper; Dexter Morin; Alan R Buckpitt
Metabolic activation and bronchiolar Clara cell necrosis from naphthalene in the isolated perfused mouse lung.
The Journal of pharmacology and experimental therapeutics 1990;252(1):428-37.
1989: Garold S Yost; Alan R Buckpitt; R A Roth; T L McLemore
Mechanisms of lung injury by systemically administered chemicals.
Toxicology and applied pharmacology 1989;101(2):179-95.
1989: K A O'Brien; C Suverkropp; S Kanekal; Charles G Plopper; Alan R Buckpitt
Tolerance to multiple doses of the pulmonary toxicant, naphthalene.
Toxicology and applied pharmacology 1989;99(3):487-500.
1989: Alan R Buckpitt; R B Franklin
Relationship of naphthalene and 2-methylnaphthalene metabolism to pulmonary bronchiolar epithelial cell necrosis.
Pharmacology & therapeutics 1989;41(1-2):393-410.
1989: M Buonarati; Dexter Morin; Charles G Plopper; Alan R Buckpitt
Glutathione depletion and cytotoxicity by naphthalene 1,2-oxide in isolated hepatocytes.
Chemico-biological interactions 1989;71(2-3):147-65.
1988: P R Richieri; Alan R Buckpitt
Glutathione depletion by naphthalene in isolated hepatocytes and by naphthalene oxide in vivo.
Biochemical pharmacology 1988;37(12):2473-8.
1987: P R Richieri; Alan R Buckpitt
Efflux of naphthalene oxide and reactive naphthalene metabolites from isolated hepatocytes.
The Journal of pharmacology and experimental therapeutics 1987;242(2):485-92.
1987: Alan R Buckpitt; N Castagnoli; S D Nelson; A Daniel Jones; L S Bahnson
Stereoselectivity of naphthalene epoxidation by mouse, rat, and hamster pulmonary, hepatic, and renal microsomal enzymes.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(4):491-8.
1986: Alan R Buckpitt; L S Bahnson
Naphthalene metabolism by human lung microsomal enzymes.
Toxicology 1986;41(3):333-41.
1986: Alan R Buckpitt; L S Bahnson; R B Franklin
Comparison of the arachidonic acid and NADPH-dependent microsomal metabolism of naphthalene and 2-methylnaphthalene and the effect of indomethacin on the bronchiolar necrosis.
Biochemical pharmacology 1986;35(4):645-50.
1985: Alan R Buckpitt; L S Bahnson; R B Franklin
Evidence that 1-naphthol is not an obligate intermediate in the covalent binding and the pulmonary bronchiolar necrosis by naphthalene.
Biochemical and biophysical research communications 1985;126(3):1097-103.
1984: Alan R Buckpitt; L S Bahnson; R B Franklin
Hepatic and pulmonary microsomal metabolism of naphthalene to glutathione adducts: factors affecting the relative rates of conjugate formation.
The Journal of pharmacology and experimental therapeutics 1984;231(2):291-300.
1984: W L Whyte; R S Pong; Alan R Buckpitt
Glutathione and glutathione S-transferases in the urinary bladder of different species.
Biochemical pharmacology 1984;33(11):1813-6.
1984: N Fakjian; Alan R Buckpitt
Metabolism of bromobenzene to glutathione adducts in lung slices from mice treated with pneumotoxicants.
Biochemical pharmacology 1984;33(9):1479-86.
1983: Alan R Buckpitt; D L Warren
Evidence for hepatic formation, export and covalent binding of reactive naphthalene metabolites in extrahepatic tissues in vivo.
The Journal of pharmacology and experimental therapeutics 1983;225(1):8-16.
1983: G Smart; Alan R Buckpitt
Formation of reactive naphthalene metabolites by target vs non-target tissue microsomes: methods for the separation of three glutathione adducts.
Biochemical pharmacology 1983;32(5):943-6.
1982: D L Brown; W Boda; M P Stone; Alan R Buckpitt
High-performance liquid chromatographic assay of cytosolic glutathione S-transferase activity with styrene oxide.
Journal of chromatography 1982;231(2):265-72.
1982: Alan R Buckpitt; M R Boyd
Metabolic activation of 4-ipomeanol by avian tissue microsomes.
Toxicology and applied pharmacology 1982;65(1):53-62.
1982: Alan R Buckpitt; C N Statham; M R Boyd
In vivo studies on the target tissue metabolism, covalent binding, glutathione depletion, and toxicity of 4-ipomeanol in birds, species deficient in pulmonary enzymes for metabolic activation.
Toxicology and applied pharmacology 1982;65(1):38-52.
1982: D L Warren; D L Brown; Alan R Buckpitt
Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene.
Chemico-biological interactions 1982;40(3):287-303.
1980: Alan R Buckpitt; M R Boyd
The in vitro formation of glutathione conjugates with the microsomally activated pulmonary bronchiolar aklylating agent and cytotoxin, 4-ipomeanol.
The Journal of pharmacology and experimental therapeutics 1980;215(1):97-103.
1980: Alan R Buckpitt; M R Boyd
A sensitive method for determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in human plasma by high-pressure liquid chromatography.
Analytical biochemistry 1980;106(2):432-7.
1980: J L Speyer; J M Collins; R L Dedrick; Murray F Brennan; Alan R Buckpitt; H Londer; V T DeVita; C E Myers
Phase I and pharmacological studies of 5-fluorouracil administered intraperitoneally.
Cancer research 1980;40(3):567-72.
1979: Alan R Buckpitt; D E Rollins; J R Mitchell
Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation.
Biochemical pharmacology 1979;28(19):2941-6.
1979: D E Rollins; Alan R Buckpitt
Liver cytosol catalyzed conjugation of reduced glutathione with a reactive metabolite of acetaminophen.
Toxicology and applied pharmacology 1979;47(2):331-9.
1979: R A Jones; Alan R Buckpitt; H H Londer; C E Myers; B A Chabner; M R Boyd
Potential clinical applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine.
Bulletin du cancer 1979;66(1):75-8.
1978: S D Nelson; W A Garland; J R Mitchell; Y Vaishnav; C N Statham; Alan R Buckpitt
Deuterium isotope effects on the metabolism and toxicity of phenacetin in hamsters.
Drug metabolism and disposition: the biological fate of chemicals 1978;6(4):363-7.
1978: Alan R Buckpitt; R P Maickel; T R Bosin
Pulmonary disposition of serotonin in the intact animal.
Biochemical pharmacology 1978;27(4):569-74.
1977: Alan R Buckpitt; D E Rollins; S D Nelson; R B Franklin; J R Mitchell
Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography.
Analytical biochemistry 1977;83(1):168-77.
1974: T R Bosin; Alan R Buckpitt; R P Maickel
Comparative gas-liquid chromatography of biologically important indoles, and their benzo(b)thiophene and 1-methylindole analogs.
Journal of chromatography 1974;94(0):316-20.
1974: T R Bosin; Alan R Buckpitt; R P Maickel
Substrate specificity of aromatic-L-amino adid decarboxylase.
Life sciences 1974;14(5):899-908.