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Sheraz Gul

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Thermodynamics

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Publications

TOP 3
Syeed Hussain; Akavish Khan; Marina Resmini; Emrys W Thomas; Chandra S Verma; Sheraz Gul; Keith Brocklehurst
Identification of interactions involved in the generation of nucleophilic reactivity and of catalytic competence in the catalytic site Cys/His ion pair of papain.
Sheraz Gul; Syeed Hussain; Mark P Thomas; Marina Resmini; chandra verma; Emrys W Thomas; Keith Brocklehurst
Generation of nucleophilic character in the Cys25/His159 ion pair of papain involves Trp177 but not Asp158.
Sheraz Gul; Geoffrey W Mellor; Emrys W Thomas; Keith Brocklehurst
Temperature-dependences of the kinetics of reactions of papain and actinidin with a series of reactivity probes differing in key molecular recognition features.

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All Publications

2011: Syeed Hussain; Akavish Khan; Marina Resmini; Emrys W Thomas; Chandra S Verma; Sheraz Gul; Keith Brocklehurst
Identification of interactions involved in the generation of nucleophilic reactivity and of catalytic competence in the catalytic site Cys/His ion pair of papain.
Biochemistry 2011;50(49):10732-42.
2008: Sheraz Gul; Syeed Hussain; Mark P Thomas; Marina Resmini; chandra verma; Emrys W Thomas; Keith Brocklehurst
Generation of nucleophilic character in the Cys25/His159 ion pair of papain involves Trp177 but not Asp158.
Biochemistry 2008;47(7):2025-35.
2006: Sheraz Gul; Geoffrey W Mellor; Emrys W Thomas; Keith Brocklehurst
Temperature-dependences of the kinetics of reactions of papain and actinidin with a series of reactivity probes differing in key molecular recognition features.
The Biochemical journal 2006;396(1):17-21.
2004: Sheraz Gul; Richard Brown; Earl May; Marie Mazzulla; Martin G Smyth; Colin Berry; Andrew Morby; David J Powell
Staphylococcus aureus DNA ligase: characterization of its kinetics of catalysis and development of a high-throughput screening compatible chemiluminescent hybridization protection assay.
The Biochemical journal 2004;383(Pt. 3):551-9.
2004: Sanjiv Sonkaria; Guillaume Boucher; José Flórez-Olvarez; Bilal Said; Syeed Hussain; Elizabeth L Ostler; Sheraz Gul; Emrys W Thomas; Marina Resmini; Gerard Gallacher; Keith Brocklehurst
Evidence for 'lock and key' character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition: variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydrolytic enzymes.
The Biochemical journal 2004;381(Pt 1):125-30.
2003: Sheraz Gul; Sanjiv Sonkaria; Surapong Pinitglang; José Florez-Alvarez; Syeed Hussain; Emrys W Thomas; Elizabeth L Ostler; Gerard Gallacher; Marina Resmini; Keith Brocklehurst
Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis.
The Biochemical journal 2003;376(Pt 3):813-21.
2002: Edward D Lowe; Ivo Tews; Robert Cheng; Nick R Brown; Sheraz Gul; Martin E M Noble; Steven J Gamblin; Louise N Johnson
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A.
Biochemistry 2002;41(52):15625-34.
2000: Michael A Noble; Sheraz Gul; chandra verma; Keith Brocklehurst
Ionization characteristics and chemical influences of aspartic acid residue 158 of papain and caricain determined by structure-related kinetic and computational techniques: multiple electrostatic modulators of active-centre chemistry.
The Biochemical journal 2000;351 Pt 3():723-33.
2000: Christopher M Topham; Sheraz Gul; Marina Resmini; Sanjiv Sonkaria; Gerard Gallacher; Keith Brocklehurst
The kinetic basis of a general method for the investigation of active site content of enzymes and catalytic antibodies: first-order behaviour under single-turnover and cycling conditions.
Journal of theoretical biology 2000;204(2):239-56.
2000: Marina Resmini; Sheraz Gul; S Carter; Sanjiv Sonkaria; Christopher M Topham; Gerard Gallacher; Keith Brocklehurst
A general kinetic approach to investigation of active-site availability in macromolecular catalysts.
The Biochemical journal 2000;346 Pt 1():117-25.
1998: Sheraz Gul; Surapong Pinitglang; Emrys W Thomas; chandra verma; Keith Brocklehurst
Sensitivities of transition state geometries to P1-P2 binding in reactions of papain and actinidin.
Biochemical Society transactions 1998;26(2):S171.
1998: Marina Resmini; Sheraz Gul; Sanjiv Sonkaria; Gerard Gallacher; Keith Brocklehurst
Determination of the catalytic site content of a polyclonal catalytic antibody preparation.
Biochemical Society transactions 1998;26(2):S170.
1997: Surapong Pinitglang; A B Watts; M Patel; James D Reid; Michael A Noble; Sheraz Gul; A Bokth; A Naeem; H Patel; Emrys W Thomas; Suneal K Sreedharan; chandra verma; Keith Brocklehurst
A classical enzyme active center motif lacks catalytic competence until modulated electrostatically.
Biochemistry 1997;36(33):9968-82.
1997: Sheraz Gul; A Clarke; B Field; M P Thomas; F Willenbrock; Surapong Pinitglang; chandra verma; Emrys W Thomas; Keith Brocklehurst
Investigation of the electrostatic field of the papain active centre by using monoprotonated and diprotonated pyridyl (Py) disulphides as reactivity probes.
Biochemical Society transactions 1997;25(1):91S.
1997: A Watts; A Hafeez; Sheraz Gul; chandra verma; Emrys W Thomas; Keith Brocklehurst
Effects of site-specific mutations on the kinetically influential ionizations of papain.
Biochemical Society transactions 1997;25(1):84S.
1996: Sheraz Gul; P S Dhillon; chandra verma; Emrys W Thomas; Keith Brocklehurst
Investigation of electrostatic interactions and binding effects in papin-ligand interaction.
Biochemical Society transactions 1996;24(3):473S.
1995: Martin J Warren; Sheraz Gul; R T Aplin; A I Scott; Charles A Roessner; P O'Grady; Peter M Shoolingin-Jordan
Evidence for conformational changes in Escherichia coli porphobilinogen deaminase during stepwise pyrrole chain elongation monitored by increased reactivity of cysteine-134 to alkylation by N-ethylmaleimide.
Biochemistry 1995;34(35):11288-95.
1994: M Patel; M P Thomas; Michael A Noble; Sheraz Gul; Emrys W Thomas; Keith Brocklehurst
Variation in the effects of P2-S2 binding contacts on catalytic site chemistry among members of the cysteine proteinase family.
Biochemical Society transactions 1994;22(2):214S.
1994: G W Mellor; M P Thomas; Sheraz Gul; Michael A Noble; Emrys W Thomas; Keith Brocklehurst
Evidence from activation parameters for enzyme active centre desolvation promoted by specific binding interactions.
Biochemical Society transactions 1994;22(2):213S.