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Veli-Matti Kähäri

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Anatomy

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Disorders

Squamous Cell Carcinoma

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Co-Publications
Name
23
Westermarck, Jukka
19
Saarialho-Kere, Ulpu
19
Ahonen, Matti
18
Heino, Jyrki
17
Ala-Aho, Risto
16
Johansson, Nina
15
Vuorio, Eero
13
Grénman, Reidar
10
Ravanti, LS
10
Häkkinen, Lari
9
Vihinen, Pia
7
Peltonen, Juha
7
Rosenbloom, Joel
7
Leivonen, Suvi-Katri
7
Pyrhönen, Seppo

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Publications

TOP 3
Kähäri Veli-Matti; Ala-Aho Risto
Stromal collagenase in melanoma: a vascular connection.
Toriseva M; Kähäri V-M
Proteinases in cutaneous wound healing.
Kangasniemi L; Koskinen M; Jokinen M; Toriseva M; Ala-Aho R; Kähäri V-M; Jalonen H; Ylä-Herttuala S; Moilanen H; Stenman U-H; Diaconu I; Kanerva A; Pesonen S; Hakkarainen T; Hemminki A
Extended release of adenovirus from silica implants in vitro and in vivo.

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All Publications

2009: Kähäri Veli-Matti; Ala-Aho Risto
Stromal collagenase in melanoma: a vascular connection.
The Journal of investigative dermatology 2009;129(11):2545-7.
2009: Toriseva M; Kähäri V-M
Proteinases in cutaneous wound healing.
Cellular and molecular life sciences : CMLS 2009;66(2):203-24.
2009: Kangasniemi L; Koskinen M; Jokinen M; Toriseva M; Ala-Aho R; Kähäri V-M; Jalonen H; Ylä-Herttuala S; Moilanen H; Stenman U-H; Diaconu I; Kanerva A; Pesonen S; Hakkarainen T; Hemminki A
Extended release of adenovirus from silica implants in vitro and in vivo.
Gene therapy 2009;16(1):103-10.
2009: Suomela Sari; Elomaa Outi; Skoog Tiina; Ala-aho Risto; Jeskanen Leila; Pärssinen Jenita; Latonen Leena; Grénman Reidar; Kere Juha; Kähäri Veli-Matti; Saarialho-Kere Ulpu
CCHCR1 is up-regulated in skin cancer and associated with EGFR expression.
PloS one 2009;4(6):e6030.
2008: Sebe Attila; Leivonen Suvi-Katri; Fintha Attila; Masszi Andras; Rosivall Laszlo; Kähäri Veli-Matti; Mucsi Istvan
Transforming growth factor-beta-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38beta mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling during epithelial-myofibroblast transdifferentiation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(5):1537-45.
2008: Luukkaa Heikki; Klemi Pekka; Hirsimäki Pirkko; Vahlberg Tero; Kivisaari Atte; Kähäri Veli-Matti; Grénman Reidar
Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer.
Acta oto-laryngologica 2008;128(4):482-90.
2008: Kivisaari A K; Kallajoki M; Mirtti T; McGrath J A; Bauer J W; Weber F; Königová R; Sawamura D; Sato-Matsumura K C; Shimizu H; Csikós M; Sinemus K; Beckert W; Kähäri V-M
Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas.
The British journal of dermatology 2008;158(4):778-85.
2007: Leivonen Suvi-Katri; Kähäri Veli-Matti
Transforming growth factor-beta signaling in cancer invasion and metastasis.
International journal of cancer. Journal international du cancer 2007;121(10):2119-24.
2007: Kajanne Risto; Miettinen Päivi; Mehlem Annika; Leivonen Suvi-Katri; Birrer Michael; Foschi Marco; Kähäri Veli-Matti; Leppä Sirpa
EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.
Journal of cellular physiology 2007;212(2):489-97.
2007: Junttila M R; Ala-Aho R; Jokilehto T; Peltonen J; Kallajoki M; Grenman R; Jaakkola P; Westermarck J; Kähäri V-M
p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells.
Oncogene 2007;26(36):5267-79.
2007: Junttila Melissa R; Puustinen Pietri; Niemelä Minna; Ahola Raija; Arnold Hugh; Böttzauw Trine; Ala-aho Risto; Nielsen Christina; Ivaska Johanna; Taya Yoichi; Lu Shi-Long; Lin Shujun; Chan Edward K L; Wang Xiao-Jing; Grènman Reidar; Kast Juergen; Kallunki Tuula; Sears Rosalie; Kähäri Veli-Matti; Westermarck Jukka
CIP2A inhibits PP2A in human malignancies.
Cell 2007;130(1):51-62.
2007: Toriseva Mervi J; Ala-aho Risto; Karvinen Jarkko; Baker Andrew H; Marjomäki Varpu S; Heino Jyrki; Kähäri Veli-Matti
Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts.
The Journal of investigative dermatology 2007;127(1):49-59.
2007: Vihinen Pia P; Hilli Johanna; Vuoristo Meri-Sisko; Syrjänen Kari J; Kähäri Veli-Matti; Pyrhönen Seppo O
Serum VEGF-C is associated with metastatic site in patients with malignant melanoma.
Acta oncologica (Stockholm, Sweden) 2007;46(5):678-84.
2006: Rönty Mikko J; Leivonen Suvi-Katri; Hinz Boris; Rachlin Andrew; Otey Carol A; Kähäri Veli-Matti; Carpén Olli M
Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation.
The Journal of investigative dermatology 2006;126(11):2387-96.
2006: Vähä-Koskela Markus J V; Kallio Janne P; Jansson Linda C; Heikkilä Jari E; Zakhartchenko Vasily A; Kallajoki Markku A; Kähäri Veli-Matti; Hinkkanen Ari E
Oncolytic capacity of attenuated replicative semliki forest virus in human melanoma xenografts in severe combined immunodeficient mice.
Cancer research 2006;66(14):7185-94.
2006: Leivonen S-K; Ala-Aho R; Koli K; Grénman R; Peltonen J; Kähäri V-M
Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells.
Oncogene 2006;25(18):2588-600.
2006: Luukkaa Marjaana; Vihinen Pia; Kronqvist Pauliina; Vahlberg Tero; Pyrhönen Seppo; Kähäri Veli-Matti; Grénman Reidar
Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer.
Head & neck 2006;28(3):225-34.
2006: Shinozaki K; Suominen E; Carrick F; Sauter B; Kähäri V-M; Lieber A; Woo S L C; Savontaus M
Efficient infection of tumor endothelial cells by a capsid-modified adenovirus.
Gene therapy 2006;13(1):52-9.
2006: Harvima Ilkka; Ranki Annamari; Reunala Timo; Kähäri Veli-Matti; Oikarinen Aarne
[How should the care of dermatological diseases be developed?]
Duodecim; lääketieteellinen aikakauskirja 2006;122(4):479; author reply 480.
2005: Joronen Kirsi; Kähäri Veli-Matti; Vuorio Eero
Temporospatial expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in mouse antigen-induced arthritis.
Histochemistry and cell biology 2005;124(6):535-45.
2005: Nikkola Johanna; Vihinen Pia; Vuoristo Meri-Sisko; Kellokumpu-Lehtinen Pirkko; Kähäri Veli-Matti; Pyrhönen Seppo
High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(14):5158-66.
2005: Leivonen Suvi-Katri; Häkkinen Lari; Liu David; Kähäri Veli-Matti
Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts.
The Journal of investigative dermatology 2005;124(6):1162-9.
2005: Vihinen Pia; Ala-aho Risto; Kähäri Veli-Matti
Matrix metalloproteinases as therapeutic targets in cancer.
Current cancer drug targets 2005;5(3):203-20.
2005: Impola U; Jeskanen L; Ravanti L; Syrjänen S; Baldursson B; Kähäri V-M; Saarialho-Kere U
Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds.
The British journal of dermatology 2005;152(4):720-6.
2005: Ala-aho Risto; Kähäri Veli-Matti
Collagenases in cancer.
Biochimie 2005;87(3-4):273-86.
2004: Koistinen Pekka; Ahonen Matti; Kähäri Veli-Matti; Heino Jyrki
alphaV integrin promotes in vitro and in vivo survival of cells in metastatic melanoma.
International journal of cancer. Journal international du cancer 2004;112(1):61-70.
2004: Ala-aho Risto; Ahonen Matti; George Sarah J; Heikkilä Jari; Grénman Reidar; Kallajoki Markku; Kähäri Veli-Matti
Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo.
Oncogene 2004;23(30):5111-23.
2004: Joronen K; Ala-aho R; Majuri M-L; Alenius H; Kähäri V-M; Vuorio E
Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice.
Annals of the rheumatic diseases 2004;63(6):656-64.
2004: Vihinen Pia; Kähäri Veli-Matti; Pyrhönen Seppo
[Prognostic factors and improving treatment of cutaneous melanoma]
Duodecim; lääketieteellinen aikakauskirja 2004;120(12):1445-56.
2003: Hieta Niina; Impola Ulla; López-Otín Carlos; Saarialho-Kere Ulpu; Kähäri Veli-Matti
Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture.
The Journal of investigative dermatology 2003;121(5):997-1004.
2003: Li Song-Ping; Junttila Melissa R; Han Jiahuai; Kähäri Veli-Matti; Westermarck Jukka
p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.
Cancer research 2003;63(13):3473-7.
2003: Ahonen Matti; Poukkula Minna; Baker Andrew H; Kashiwagi Masahide; Nagase Hideaki; Eriksson John E; Kähäri Veli-Matti
Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors.
Oncogene 2003;22(14):2121-34.
2003: Impola Ulla; Toriseva Mervi; Suomela Sari; Jeskanen Leila; Hieta Niina; Jahkola Tiina; Grenman Reidar; Kähäri Veli-Matti; Saarialho-Kere Ulpu
Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation.
International journal of cancer. Journal international du cancer 2003;103(6):709-16.
2003: Iivanainen Erika; Kähäri Veli-Matti; Heino Jyrki; Elenius Klaus
Endothelial cell-matrix interactions.
Microscopy research and technique 2003;60(1):13-22.
2003: Vihinen Pia P; Pyrhönen Seppo O; Kähäri Veli-Matti
New prognostic factors and developing therapy of cutaneous melanoma.
Annals of medicine 2003;35(2):66-78.
2002: Leivonen Suvi-Katri; Chantry Andrew; Hakkinen Lari; Han Jiahuai; Kahari Veli-Matti
Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways.
The Journal of biological chemistry 2002;277(48):46338-46.
2002: Kerkelä Erja; Ala-aho Risto; Klemi Pekka; Grénman Seija; Shapiro Steven D; Kähäri Veli-Matti; Saarialho-Kere Ulpu
Metalloelastase (MMP-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome.
The Journal of pathology 2002;198(2):258-69.
2002: Reunanen Niina; Li Song-Ping; Ahonen Matti; Foschi Marco; Han Jiahuai; Kähäri Veli-Matti
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization.
The Journal of biological chemistry 2002;277(35):32360-8.
2002: Ahonen Matti; Ala-Aho Risto; Baker Andrew H; George Sarah J; Grénman Reidar; Saarialho-Kere Ulpu; Kähäri Veli-Matti
Antitumor activity and bystander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):705-15.
2002: Vihinen Pia; Kähäri Veli-Matti
Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets.
International journal of cancer. Journal international du cancer 2002;99(2):157-66.
2002: Mori Yasuji; Kahari Veli-Matti; Varga John
Scleroderma-like cutaneous syndromes.
Current rheumatology reports 2002;4(2):113-22.
2002: Ivaska Johanna; Nissinen Liisa; Immonen Nina; Eriksson John E; Kähäri Veli-Matti; Heino Jyrki
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.
Molecular and cellular biology 2002;22(5):1352-9.
2002: Ala-aho Risto; Grénman Reidar; Seth Prem; Kähäri Veli-Matti
Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells.
Oncogene 2002;21(8):1187-95.
2002: Nikkola Johanna; Vihinen Pia; Vlaykova Tatyana; Hahka-Kemppinen Marjo; Kähäri Veli-Matti; Pyrhönen Seppo
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.
International journal of cancer. Journal international du cancer 2002;97(4):432-8.
2002: Chen Zhi; Ahonen Matti; Hämäläinen Heli; Bergelson Jeffrey M; Kähäri Veli Matti; Lahesmaa Riitta
High-efficiency gene transfer to primary T lymphocytes by recombinant adenovirus vectors.
Journal of immunological methods 2002;260(1-2):79-89.
2002: Ala-Aho Risto; Johansson Nina; Baker Andrew H; Kähäri Veli-Matti
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells.
International journal of cancer. Journal international du cancer 2002;97(3):283-9.
2001: Uusitalo H; Hiltunen A; Ahonen M; Gao T J; Lefebvre V; Harley V; Kähäri V M; Vuorio E
Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1837-45.
2001: Tran S E; Holmstrom T H; Ahonen M; Kahari V M; Eriksson J E
MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors.
The Journal of biological chemistry 2001;276(19):16484-90.
2001: Söderström M; Aro H T; Ahonen M; Johansson N; Aho A; Ekfors T; Böhling T; Kähäri V M; Vuorio E
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2001;109(4):305-15.
2001: Uusitalo H; Rantakokko J; Ahonen M; Jämsä T; Tuukkanen J; KäHäri V; Vuorio E; Aro H T
A metaphyseal defect model of the femur for studies of murine bone healing.
Bone 2001;28(4):423-9.
2001: Uusitalo H; Hiltunen A; Ahonen M; Kähäri V M; Aro H; Vuorio E
Induction of periosteal callus formation by bone morphogenetic protein-2 employing adenovirus-mediated gene delivery.
Matrix biology : journal of the International Society for Matrix Biology 2001;20(2):123-7.
2001: Nikkola J; Vihinen P; Vlaykova T; Hahka-Kemppinen M; Kähäri V M; Pyrhönen S
High collagenase-1 expression correlates with a favourable chemoimmunotherapy response in human metastatic melanoma.
Melanoma research 2001;11(2):157-66.
2001: Ravanti L; Toriseva M; Penttinen R; Crombleholme T; Foschi M; Han J; Kähäri V M
Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor beta via p38 mitogen-activated protein kinase.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1098-100.
2001: Westermarck J; Li S P; Kallunki T; Han J; Kähäri V M
p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.
Molecular and cellular biology 2001;21(7):2373-83.
2001: Hukkanen V; Kähäri V M; Hyypiä T
[Viruses as helpful instruments in medicine]
Duodecim; lääketieteellinen aikakauskirja 2001;117(10):1059-65.
2001: Laato M; Heino J; Gerdin B; Kähäri V M; Niinikoski J
Interferon-gamma-induced inhibition of wound healing in vivo and in vitro.
Annales chirurgiae et gynaecologiae 2001;90 Suppl 215():19-23.
2001: Laato M; Heino J; Gerdin B; Kähäri V M; Niinikoski J
Interferon-gamma-induced inhibition of wound healing in vivo and in vitro.
Annales chirurgiae et gynaecologiae. Supplementum 2001;(215):19-23.
2000: Westermarck J; Li S; Jaakkola P; Kallunki T; Grénman R; Kähäri V M
Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.
Cancer research 2000;60(24):7156-62.
2000: Häkkinen L; Strassburger S; Kähäri V M; Scott P G; Eichstetter I; Lozzo R V; Larjava H
A role for decorin in the structural organization of periodontal ligament.
Laboratory investigation; a journal of technical methods and pathology 2000;80(12):1869-80.
2000: Boström P J; Ravanti L; Reunanen N; Aaltonen V; Söderström K O; Kähäri V M; Laato M
Expression of collagenase-3 (matrix metalloproteinase-13) in transitional-cell carcinoma of the urinary bladder.
International journal of cancer. Journal international du cancer 2000;88(3):417-23.
2000: Reunanen N; Foschi M; Han J; Kahari V M
Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts.
The Journal of biological chemistry 2000;275(44):34634-9.
2000: Jaakkola P; Ahonen M; Kähäri V M; Jalkanen M
Transcriptional targeting of adenoviral gene delivery into migrating wound keratinocytes using FiRE, a growth factor-inducible regulatory element.
Gene therapy 2000;7(19):1640-7.
2000: Ekholm E C; Ravanti L; Kähäri V; Paavolainen P; Penttinen R P
Expression of extracellular matrix genes: transforming growth factor (TGF)-beta1 and ras in tibial fracture healing of lathyritic rats.
Bone 2000;27(4):551-7.
2000: Ravanti L; Kähäri V M
Matrix metalloproteinases in wound repair (review).
International journal of molecular medicine 2000;6(4):391-407.
2000: Laine P; Reunanen N; Ravanti L; Foschi M; Santra M; Iozzo R V; Kähäri V M
Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts.
The Biochemical journal 2000;349(Pt 1):19-25.
2000: Kerkelä E; Ala-Aho R; Jeskanen L; Rechardt O; Grénman R; Shapiro S D; Kähäri V M; Saarialho-Kere U
Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer.
The Journal of investigative dermatology 2000;114(6):1113-9.
2000: Inkinen K; Turakainen H; Wolff H; Ravanti L; Kähäri V M; Ahonen J
Expression and activity of matrix metalloproteinase-2 and -9 in experimental granulation tissue.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2000;108(5):318-28.
2000: Johansson N; Ahonen M; Kähäri V M
Matrix metalloproteinases in tumor invasion.
Cellular and molecular life sciences : CMLS 2000;57(1):5-15.
2000: Johansson N; Kähäri V M
Matrix metalloproteinases in squamous cell carcinoma.
Histology and histopathology 2000;15(1):225-37.
2000: Ala-aho R; Johansson N; Grénman R; Fusenig N E; López-Otín C; Kähäri V M
Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1.
Oncogene 2000;19(2):248-57.
2000: Johansson N; Ala-aho R; Uitto V; Grénman R; Fusenig N E; López-Otín C; Kähäri V M
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase.
Journal of cell science 2000;113 Pt 2():227-35.
2000: Baker A H; Ahonen M; Kähäri V M
Potential applications of tissue inhibitor of metalloproteinase (TIMP) overexpression for cancer gene therapy.
Advances in experimental medicine and biology 2000;465():469-83.
1999: Ravanti L; Häkkinen L; Larjava H; Saarialho-Kere U; Foschi M; Han J; Kähäri V M
Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase.
The Journal of biological chemistry 1999;274(52):37292-300.
1999: Ivaska J; Reunanen H; Westermarck J; Koivisto L; Kähäri V M; Heino J
Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail.
The Journal of cell biology 1999;147(2):401-16.
1999: Westermarck J; Kähäri V M
Regulation of matrix metalloproteinase expression in tumor invasion.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):781-92.
1999: Kähäri V M; Saarialho-Kere U
Matrix metalloproteinases and their inhibitors in tumour growth and invasion.
Annals of medicine 1999;31(1):34-45.
1999: Johansson N; Vaalamo M; Grénman S; Hietanen S; Klemi P; Saarialho-Kere U; Kähäri V M
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
The American journal of pathology 1999;154(2):469-80.
1999: Ravanti L; Heino J; López-Otín C; Kähäri V M
Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.
The Journal of biological chemistry 1999;274(4):2446-55.
1998: Westermarck J; Holmström T; Ahonen M; Eriksson J E; Kähäri V M
Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(8-9):547-57.
1998: Nelimarkka L O; Nikkari S T; Ravanti L S; Kähäri V M; Järveläinen H T
Collagenase-1, stromelysin-1 and 92 kDa gelatinase are associated with tumor necrosis factor-alpha induced morphological change of human endothelial cells in vitro.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(4):293-304.
1998: Nissinen L; Westermarck J; Koivisto L; Kähäri V M; Heino J
Transcription of alpha2 integrin gene in osteosarcoma cells is enhanced by tumor promoters.
Experimental cell research 1998;243(1):1-10.
1998: Uitto V J; Airola K; Vaalamo M; Johansson N; Putnins E E; Firth J D; Salonen J; López-Otín C; Saarialho-Kere U; Kähäri V M
Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation.
The American journal of pathology 1998;152(6):1489-99.
1998: Ahonen M; Baker A H; Kähäri V M
Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.
Cancer research 1998;58(11):2310-5.
1998: Mattila L; Airola K; Ahonen M; Hietarinta M; Black C; Saarialho-Kere U; Kähäri V M
Activation of tissue inhibitor of metalloproteinases-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts.
The Journal of investigative dermatology 1998;110(4):416-21.
1998: Airola K; Ahonen M; Johansson N; Heikkilä P; Kere J; Kähäri V M; Saarialho-Kere U K
Human TIMP-3 is expressed during fetal development, hair growth cycle, and cancer progression.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(4):437-47.
1998: Isoherranen K; Westermarck J; Kähäri V M; Jansén C; Punnonen K
Differential regulation of the AP-1 family members by UV irradiation in vitro and in vivo.
Cellular signalling 1998;10(3):191-5.
1998: Reunanen N; Westermarck J; Häkkinen L; Holmström T H; Elo I; Eriksson J E; Kähäri V M
Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways.
The Journal of biological chemistry 1998;273(9):5137-45.
1998: Häkkinen L; Westermarck J; Johansson N; Aho H; Peltonen J; Heino J; Kähäri V M
Suprabasal expression of epidermal alpha 2 beta 1 and alpha 3 beta 1 integrins in skin treated with topical retinoic acid.
The British journal of dermatology 1998;138(1):29-36.
1998: Ahonen M; Baker A H; Kähäri V M
High level expression of tissue inhibitors of metalloproteinases-1,-2 and -3 in melanoma cells achieved by adenovirus mediated gene transfer.
Advances in experimental medicine and biology 1998;451():69-72.
1998: Kähäri V M; Johansson N; Grénman R; Airola K; Saarialho-Kere U
Expression of collagenase-3 (MMP-13) by tumor cells in squamous cell carcinomas of the head and neck.
Advances in experimental medicine and biology 1998;451():63-8.
1997: Varga J; Kähäri V M
Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders.
Current opinion in rheumatology 1997;9(6):562-70.
1997: Kähäri V M; Saarialho-Kere U
Matrix metalloproteinases in skin.
Experimental dermatology 1997;6(5):199-213.
1997: Johansson N; Airola K; Grénman R; Kariniemi A L; Saarialho-Kere U; Kähäri V M
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.
The American journal of pathology 1997;151(2):499-508.
1997: Airola K; Johansson N; Kariniemi A L; Kähäri V M; Saarialho-Kere U K
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
The Journal of investigative dermatology 1997;109(2):225-31.
1997: Vaalamo M; Mattila L; Johansson N; Kariniemi A L; Karjalainen-Lindsberg M L; Kähäri V M; Saarialho-Kere U
Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds.
The Journal of investigative dermatology 1997;109(1):96-101.
1997: Westermarck J; Seth A; Kähäri V M
Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors.
Oncogene 1997;14(22):2651-60.
1997: Johansson N; Saarialho-Kere U; Airola K; Herva R; Nissinen L; Westermarck J; Vuorio E; Heino J; Kähäri V M
Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;208(3):387-97.
1997: Johansson N; Westermarck J; Leppä S; Häkkinen L; Koivisto L; López-Otín C; Peltonen J; Heino J; Kähäri V M
Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(2):243-50.
1996: Häkkinen L; Westermarck J; Kähäri V M; Larjava H
Human granulation-tissue fibroblasts show enhanced proteoglycan gene expression and altered response to TGF-beta 1.
Journal of dental research 1996;75(10):1767-78.
1996: Lohi J; Lehti K; Westermarck J; Kähäri V M; Keski-Oja J
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.
European journal of biochemistry / FEBS 1996;239(2):239-47.
1995: Westermarck J; Häkkinen L; Fiers W; Kähäri V M
TNF-R55-specific form of human tumor necrosis factor-alpha induces collagenase gene expression by human skin fibroblasts.
The Journal of investigative dermatology 1995;105(2):197-202.
1995: Westermarck J; Ilvonen E; Kähäri V M
The protein phosphatase inhibitor okadaic acid suppresses type I collagen gene expression in cultured fibroblasts at the transcriptional level.
The Biochemical journal 1995;308 ( Pt 3)():995-9.
1995: Riikonen T; Westermarck J; Koivisto L; Broberg A; Kähäri V M; Heino J
Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression.
The Journal of biological chemistry 1995;270(22):13548-52.
1995: Westermarck J; Ilvonen E; Uitto J; Kähäri V M
Suppression of elastin gene expression in dermal fibroblasts by protein phosphatase inhibitor okadaic acid.
Biochemical and biophysical research communications 1995;209(1):175-81.
1995: Kähäri V M; Häkkinen L; Westermarck J; Larjava H
Differential regulation of decorin and biglycan gene expression by dexamethasone and retinoic acid in cultured human skin fibroblasts.
The Journal of investigative dermatology 1995;104(4):503-8.
1994: Westermarck J; Lohi J; Keski-Oja J; Kähäri V M
Okadaic acid-elicited transcriptional activation of collagenase gene expression in HT-1080 fibrosarcoma cells is mediated by JunB.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(11):1205-13.
1994: Kähäri V M
Dexamethasone suppresses elastin gene expression in human skin fibroblasts in culture.
Biochemical and biophysical research communications 1994;201(3):1189-96.
1994: Lohi J; Kähäri V M; Keski-Oja J
Cyclosporin A enhances cytokine and phorbol ester-induced fibroblast collagenase expression.
The Journal of investigative dermatology 1994;102(6):938-44.
1993: Kähäri V M
Activation of dermal connective tissue in scleroderma.
Annals of medicine 1993;25(6):511-8.
1993: Mauviel A; Chen Y Q; Kähäri V M; Ledo I; Wu M; Rudnicka L; Uitto J
Human recombinant interleukin-1 beta up-regulates elastin gene expression in dermal fibroblasts. Evidence for transcriptional regulation in vitro and in vivo.
The Journal of biological chemistry 1993;268(9):6520-4.
1992: Kähäri V M; Chen Y Q; Bashir M M; Rosenbloom J; Uitto J
Tumor necrosis factor-alpha down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity.
The Journal of biological chemistry 1992;267(36):26134-41.
1992: Mauviel A; Kähäri V M; Kurkinen M; Evans C H; Uitto J
Leukoregulin, a T-cell derived cytokine, upregulates stromelysin-1 gene expression in human dermal fibroblasts: evidence for the role of AP-1 in transcriptional activation.
Journal of cellular biochemistry 1992;50(1):53-61.
1992: Kähäri V M; Olsen D R; Rhudy R W; Carrillo P; Chen Y Q; Uitto J
Transforming growth factor-beta up-regulates elastin gene expression in human skin fibroblasts. Evidence for post-transcriptional modulation.
Laboratory investigation; a journal of technical methods and pathology 1992;66(5):580-8.
1992: Mauviel A; Kähäri V M; Evans C H; Uitto J
Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin.
The Journal of biological chemistry 1992;267(8):5644-8.
1992: Mauviel A; Kähäri V M; Chen Y Q; Kurkinen M; Evans C H; Uitto J
Transcriptional activation of fibroblast stromelysin-1 and collagenase gene expression by a novel lymphokine, leukoregulin.
Transactions of the Association of American Physicians 1992;105():100-9.
1991: Uitto J; Christiano A M; Kähäri V M; Bashir M M; Rosenbloom J
Molecular biology and pathology of human elastin.
Biochemical Society transactions 1991;19(4):824-9.
1991: Fazio M J; O'Leary J; Kähäri V M; Chen Y Q; Saitta B; Uitto J
Human nidogen gene: structural and functional characterization of the 5'-flanking region.
The Journal of investigative dermatology 1991;97(2):281-5.
1991: Kähäri V M; Peltonen J; Chen Y Q; Uitto J
Differential modulation of basement membrane gene expression in human fibrosarcoma HT-1080 cells by transforming growth factor-beta 1. Enhanced type IV collagen and fibronectin gene expression correlates with altered culture phenotype of the cells.
Laboratory investigation; a journal of technical methods and pathology 1991;64(6):807-18.
1991: Kähäri V M; Larjava H; Uitto J
Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in culture.
The Journal of biological chemistry 1991;266(16):10608-15.
1991: Vuorio T; Kähäri V M; Black C; Vuorio E
Expression of osteonectin, decorin, and transforming growth factor-beta 1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea.
The Journal of rheumatology 1991;18(2):247-51.
1991: Mauviel A; Heino J; Kähäri V M; Hartmann D J; Loyau G; Pujol J P; Vuorio E
Comparative effects of interleukin-1 and tumor necrosis factor-alpha on collagen production and corresponding procollagen mRNA levels in human dermal fibroblasts.
The Journal of investigative dermatology 1991;96(2):243-9.
1991: Rosenbloom J; Bashir M; Yeh H; Rosenbloom J; Ornstein-Goldstein N; Fazio M; Kahari V M; Uitto J
Regulation of elastin gene expression.
Annals of the New York Academy of Sciences 1991;624():116-36.
1991: Rosenbloom J; Bashir M; Kahari V M; Uitto J
Elastin genes and regulation of their expression.
Critical reviews in eukaryotic gene expression 1991;1(3):145-56.
1991: Kähäri V M; Reitamo S; Granlund H; Uitto J
[The fibrotic diseases of the skin]
Duodecim; lääketieteellinen aikakauskirja 1991;107(12):957-70.
1990: Kähäri V M; Chen Y Q; Su M W; Ramirez F; Uitto J
Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.
The Journal of clinical investigation 1990;86(5):1489-95.
1990: Kähäri V M; Fazio M J; Chen Y Q; Bashir M M; Rosenbloom J; Uitto J
Deletion analyses of 5'-flanking region of the human elastin gene. Delineation of functional promoter and regulatory cis-elements.
The Journal of biological chemistry 1990;265(16):9485-90.
1990: Peltonen J; Kähäri L; Jaakkola S; Kähäri V M; Varga J; Uitto J; Jimenez S A
Evaluation of transforming growth factor beta and type I procollagen gene expression in fibrotic skin diseases by in situ hybridization.
The Journal of investigative dermatology 1990;94(3):365-71.
1990: Fazio M J; Kähäri V M; Bashir M M; Saitta B; Rosenbloom J; Uitto J
Regulation of elastin gene expression: evidence for functional promoter activity in the 5'-flanking region of the human gene.
The Journal of investigative dermatology 1990;94(2):191-6.
1989: Laato M; Heino J; Kähäri V M; Niinikoski J; Gerdin B
Epidermal growth factor (EGF) prevents methylprednisolone-induced inhibition of wound healing.
The Journal of surgical research 1989;47(4):354-9.
1989: Larjava H; Heino J; Kähäri V M; Krusius T; Vuorio E
Characterization of one phenotype of human periodontal granulation-tissue fibroblasts.
Journal of dental research 1989;68(1):20-5.
1989: Heino J; Kähäri V M; Jaakkola S; Peltonen J
Collagen in the extracellular matrix of cultured scleroderma skin fibroblasts: changes related to ascorbic acid-treatment.
Matrix (Stuttgart, Germany) 1989;9(1):34-9.
1988: Kähäri V M; Sandberg M; Kalimo H; Vuorio T; Vuorio E
Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization.
The Journal of investigative dermatology 1988;90(5):664-70.
1988: Heino J; Kähäri V M; Mauviel A; Krusius T
Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein.
The Biochemical journal 1988;252(1):309-12.
1988: Mauviel A; Kähäri V M; Heino J; Daireaux M; Hartmann D J; Loyau G; Pujol J P
Gene expression of fibroblast matrix proteins is altered by indomethacin.
FEBS letters 1988;231(1):125-9.
1988: Kähäri V M; Heino J; Vuorio T; Vuorio E
Interferon-alpha and interferon-gamma reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture.
Biochimica et biophysica acta 1988;968(1):45-50.
1988: Kähäri V M; Eerola E; Vuorio E
Flow cytometry of fibroblasts cultured from skin of patients with localized scleroderma.
Dermatologica 1988;177(6):348-53.
1987: Laato M; Kähäri V M; Niinikoski J; Vuorio E
Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes.
The Biochemical journal 1987;247(2):385-8.
1987: Kähäri V M; Heino J; Vuorio E
Interleukin-1 increases collagen production and mRNA levels in cultured skin fibroblasts.
Biochimica et biophysica acta 1987;929(2):142-7.
1987: Kähäri V M; Multimäki P; Vuorio E
Elevated pro alpha 2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene.
FEBS letters 1987;215(2):331-4.
1987: Mäkinen J; Kähäri V M; Söderström K O; Vuorio E; Hirvonen T
Collagen synthesis in the vaginal connective tissue of patients with and without uterine prolapse.
European journal of obstetrics, gynecology, and reproductive biology 1987;24(4):319-25.
1987: Vuorio T; Mäkelä J K; Kähäri V M; Vuorio E
Coordinated regulation of type I and type III collagen production and mRNA levels of pro alpha 1(I) and pro alpha 2(I) collagen in cultured morphea fibroblasts.
Archives of dermatological research 1987;279(3):154-60.
1987: Kähäri V M; Heino J; Larjava H; Vuorio E
Alterations in scleroderma fibroblast surface glycoproteins associated with increased collagen synthesis.
Acta dermato-venereologica 1987;67(3):199-205.
1984: Kähäri V M; Vuorio T; Näntö-Salonen K; Vuorio E
Increased type I collagen mRNA levels in cultured scleroderma fibroblasts.
Biochimica et biophysica acta 1984;781(1-2):183-6.
1984: Vuorio T K; Kähäri V M; Lehtonen A; Vuorio E I
Fibroblast activation in scleroderma.
Scandinavian journal of rheumatology 1984;13(3):229-37.

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