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Michael Spoerner

Research Profile

Chemicals & Drugs

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Nuclear Magnetic Resonance, Biomolecular

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TOP 3
Ina C Rosnizeck; Michael Spoerner; Burkhard König; Sandra Kreitner; Daniel Engel; Daniel Filchtinski; Tobias Harsch; Christian Herrmann; Hans Robert Kalbitzer
Metal-bis(2-picolyl)amine complexes as state 1(T) inhibitors of activated Ras protein.
Timo Sieber; Michael Spoerner; Hans Robert Kalbitzer; Roland Scholz; Frank Schumann; Thomas Dobner
Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R.
Tanja Meierhofer; Maren Eberhardt; Michael Spoerner
Conformational states of ADP ribosylation factor 1 complexed with different guanosine triphosphates as studied by 31P NMR spectroscopy.

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All Publications

2012: Ina C Rosnizeck; Michael Spoerner; Burkhard König; Sandra Kreitner; Daniel Engel; Daniel Filchtinski; Tobias Harsch; Christian Herrmann; Hans Robert Kalbitzer
Metal-bis(2-picolyl)amine complexes as state 1(T) inhibitors of activated Ras protein.
Angewandte Chemie (International ed. in English) 2012;51(42):10647-51.
2011: Timo Sieber; Michael Spoerner; Hans Robert Kalbitzer; Roland Scholz; Frank Schumann; Thomas Dobner
Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R.
Virology 2011;418(2):133-43.
2011: Tanja Meierhofer; Maren Eberhardt; Michael Spoerner
Conformational states of ADP ribosylation factor 1 complexed with different guanosine triphosphates as studied by 31P NMR spectroscopy.
Biochemistry 2011;50(29):6316-27.
2011: Tanja Meierhofer; Ina C Rosnizeck; Thorsten Graf; Kerstin Reiss; Burkhard König; Hans Robert Kalbitzer; Michael Spoerner
Cu2+-cyclen as probe to identify conformational states in guanine nucleotide binding proteins.
Journal of the American Chemical Society 2011;133(7):2048-51.
2010: Michael Spoerner; Constantin Hozsa; Johann A Poetzl; Kerstin Reiss; Petra Ganser; Matthias Geyer; Hans Robert Kalbitzer
Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.
The Journal of biological chemistry 2010;285(51):39768-78.
2010: Ina C Rosnizeck; Thorsten Graf; Michael Spoerner; Jens Tränkle; Daniel Filchtinski; Christian Herrmann; Lothar Gremer; Ingrid R Vetter; Alfred Wittinghofer; Burkhard König; Hans Robert Kalbitzer
Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes.
Angewandte Chemie (International ed. in English) 2010;49(22):3830-3.
2009: Hans Robert Kalbitzer; Michael Spoerner; Petra Ganser; Constantin Hozsa; Werner Kremer
Fundamental link between folding states and functional states of proteins.
Journal of the American Chemical Society 2009;131(46):16714-9.
2009: Christina Kiel; Daniel Filchtinski; Michael Spoerner; Gideon Schreiber; Hans Robert Kalbitzer; Christian Herrmann
Improved binding of raf to Ras.GDP is correlated with biological activity.
The Journal of biological chemistry 2009;284(46):31893-902.
2009: Christian Spangler; Corinna M Spangler; Michael Spoerner; Michael Schäferling
Kinetic determination of the GTPase activity of Ras proteins by means of a luminescent terbium complex.
Analytical and bioanalytical chemistry 2009;394(4):989-96.
2007: Christian Ader; Michael Spoerner; Hans Robert Kalbitzer; Eike Brunner
Solid-state 31P NMR spectroscopy of precipitated guanine nucleotide-binding protein Ras in complexes with its effector molecules Raf kinase and RalGDS.
The journal of physical chemistry. B 2007;111(10):2752-7.
2007: Michael Spoerner; Andrea Nuehs; Christian Herrmann; Guido Steiner; Hans Robert Kalbitzer
Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS.
The FEBS journal 2007;274(6):1419-33.
2006: Adriana Iuga; Michael Spoerner; Christian Ader; Eike Brunner; Hans Robert Kalbitzer
Rapid assignment of solution 31P NMR spectra of large proteins by solid-state spectroscopy.
Biochemical and biophysical research communications 2006;346(1):301-5.
2006: Marina Bennati; Melanie M Hertel; Jörg Fritscher; Thomas F Prisner; Norbert Weiden; Roland Hofweber; Michael Spoerner; Gudrun Horn; Hans Robert Kalbitzer
High-frequency 94 GHz ENDOR characterization of the metal binding site in wild-type Ras x GDP and its oncogenic mutant G12V in frozen solution.
Biochemistry 2006;45(1):42-50.
2005: Michael Spoerner; Thomas F Prisner; Marina Bennati; Melanie M Hertel; Norbert Weiden; Thomas Schweins; Hans Robert Kalbitzer
Conformational states of human H-Ras detected by high-field EPR, ENDOR, and 31P NMR spectroscopy.
Magnetic resonance in chemistry : MRC 2005;43 Spec no.():S74-83.
2005: Michael Spoerner; Thorsten Graf; Burkhard König; Hans Robert Kalbitzer
A novel mechanism for the modulation of the Ras-effector interaction by small molecules.
Biochemical and biophysical research communications 2005;334(2):709-13.
2005: Michael Spoerner; Andrea Nuehs; Petra Ganser; Christian Herrmann; Alfred Wittinghofer; Hans Robert Kalbitzer
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins.
Biochemistry 2005;44(6):2225-36.
2004: Michael Spoerner; Alfred Wittinghofer; Hans Robert Kalbitzer
Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy.
FEBS letters 2004;578(3):305-10.
2004: Adriana Iuga; Michael Spoerner; Hans Robert Kalbitzer; Eike Brunner
Solid-state 31P NMR spectroscopy of microcrystals of the Ras protein and its effector loop mutants: comparison between crystalline and solution state.
Journal of molecular biology 2004;342(3):1033-40.
2001: Wolfram Gronwald; F Huber; P Grünewald; Michael Spoerner; Sabine Wohlgemuth; Christian Herrmann; Hans Robert Kalbitzer
Solution structure of the Ras binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe.
Structure (London, England : 1993) 2001;9(11):1029-41.
2001: Michael Spoerner; Christian Herrmann; Ingrid R Vetter; Hans Robert Kalbitzer; Alfred Wittinghofer
Dynamic properties of the Ras switch I region and its importance for binding to effectors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):4944-9.
2001: M Rohrer; Thomas F Prisner; O Brügmann; H Käss; Michael Spoerner; Alfred Wittinghofer; Hans Robert Kalbitzer
Structure of the metal-water complex in Ras x GDP studied by high-field EPR spectroscopy and 31P NMR spectroscopy.
Biochemistry 2001;40(7):1884-9.