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Taisuke Tomita

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Shizuka Takagi-Niidome; Taisuke Tomita; Satoko Osawa; Takeshi Iwatsubo
Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.
Nobumasa Takasugi; Koji Takeo; Taisuke Tomita; Ihori Ebinuma; Hayato Isshiki; Satoko Osawa; Tomoki Sasaki; Takeshi Iwatsubo
FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons.
Taisuke Tomita
[Understanding the structure-and-function relationships of gamma-secretase toward the modulation of intramembrane-cleaving activity].

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2013: Shizuka Takagi-Niidome; Taisuke Tomita; Satoko Osawa; Takeshi Iwatsubo
Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.
Biochemistry 2013;52(1):61-9.
2013: Nobumasa Takasugi; Koji Takeo; Taisuke Tomita; Ihori Ebinuma; Hayato Isshiki; Satoko Osawa; Tomoki Sasaki; Takeshi Iwatsubo
FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons.
PloS one 2013;8(5):e64050.
2012: Taisuke Tomita
[Understanding the structure-and-function relationships of gamma-secretase toward the modulation of intramembrane-cleaving activity].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():321-5.
2012: Kunimichi Suzuki; Shun Tanimura; Taisuke Tomita; Satoshi Yokoshima; Mingshuo Zeng; Tohru Fukuyama; Yukari Hayashi; Keisuke Horiuchi; Ryuta Koyama; Hiroshi Kumazaki; Norio Matsuki; Soichiro Nakahara; Yoshitake Nishiyama; Satoko Osawa; Johannes Prox; Paul Saftig; Atsuko Sehara-Fujisawa; Takeshi Iwatsubo
Activity-dependent proteolytic cleavage of neuroligin-1.
Neuron 2012;76(2):410-22.
2012: Ikuo Hayashi; Hiroko Iwanari; S Chiba; Takao Hamakubo; Tatsuhiko Kodama; Tong Li; Y Miyake; Yuichi Morohashi; S Osawa; Mamiko Sakata-Yanagimoto; J Takagi; S Takatori; Taisuke Tomita; Yasuomi Urano; Philip C Wong; Takeshi Iwatsubo
Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.
Oncogene 2012;31(6):787-98.
2012: Taisuke Tomita
[Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity].
Rinshō shinkeigaku = Clinical neurology 2012;52(11):1165-7.
2011: Yu Ohki; Satoko Osawa; Naoaki Shimada; Taisuke Tomita; Kengo Uemura; Satoshi Yokoshima; Oksana Berezovska; Tohru Fukuyama; Takuya Higo; Takeshi Iwatsubo
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.
The EMBO journal 2011;30(23):4815-24.
2011: Taisuke Tomita
[Presenilin gene].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 8():98-102.
2011: Hiroyuki Miyashita; Toshihiko Ogura; Satoko Osawa; Chikara Sato; Taisuke Tomita; Hayato Isshiki; Yuusuke Maruyama; Kazuhiro Mio; Takeshi Iwatsubo
Three-dimensional structure of the signal peptide peptidase.
The Journal of biological chemistry 2011;286(29):26188-97.
2011: Nobumasa Takasugi; Taisuke Tomita; John Q Trojanowski; Satoshi Yokoshima; Tohru Fukuyama; Takuya Higo; Yukiko Hori; Hayato Isshiki; Virginia M-Y Lee; Satoko Osawa; Tomoki Sasaki; Naoaki Shimada; Kunimichi Suzuki; Takeshi Iwatsubo
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(18):6850-7.
2011: Taisuke Tomita; Philip C Wong
Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's.
Alzheimer's research & therapy 2011;3(2):7.
2010: Masashi Asai; Nobuhisa Iwata; Taisuke Tomita; Takeshi Iwatsubo; Shoichi Ishiura; Takaomi C Saido; Kei Maruyama
Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.
Journal of neuroscience research 2010;88(16):3588-97.
2010: Shizuka Takagi; Aya Tominaga; Chihiro Sato; Taisuke Tomita; Takeshi Iwatsubo
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(47):15943-50.
2010: Yuichi Morohashi; Taisuke Tomita; Takeshi Iwatsubo
[Molecular targeted therapy in Alzheimer disease].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(10):1906-10.
2010: Hiroaki Fukumoto; Hideki Takahashi; Naoki Tarui; Junji Matsui; Taisuke Tomita; Mitsuhiro Hirode; Masumi Sagayama; Ryouta Maeda; Makiko Kawamoto; Kazuko Hirai; Jun Terauchi; Yasufumi Sakura; Mitsuru Kakihana; Kaneyoshi Kato; Takeshi Iwatsubo; Masaomi Miyamoto
A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(33):11157-66.
2009: Satoshi Yokoshima; Yuzo Abe; Naoto Watanabe; Yoichi Kita; Toshiyuki Kan; Takeshi Iwatsubo; Taisuke Tomita; Tohru Fukuyama
Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.
Bioorganic & medicinal chemistry letters 2009;19(24):6869-71.
2009: Shigeo Masuda; Keiki Kumano; Takahiro Suzuki; Taisuke Tomita; Takeshi Iwatsubo; Hideaki Natsugari; Arinobu Tojo; Makoto Shibutani; Kunitoshi Mitsumori; Yutaka Hanazono; Seishi Ogawa; Mineo Kurokawa; Shigeru Chiba
Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.
Cancer science 2009;100(12):2444-50.
2009: Taisuke Tomita
[Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity].
Rinshō shinkeigaku = Clinical neurology 2009;49(11):845-7.
2009: Ikuo Hayashi; Sho Takatori; Yasuomi Urano; Hiroko Iwanari; Noriko Isoo; Satoko Osawa; Maiko A Fukuda; Tatsuhiko Kodama; Takao Hamakubo; Tong Li; Philip C Wong; Taisuke Tomita; Takeshi Iwatsubo
Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.
The Journal of biological chemistry 2009;284(41):27838-47.
2009: Yuki Imamura; Naoto Watanabe; Naoki Umezawa; Takeshi Iwatsubo; Nobuki Kato; Taisuke Tomita; Tsunehiko Higuchi
Inhibition of gamma-secretase activity by helical beta-peptide foldamers.
Journal of the American Chemical Society 2009;131(21):7353-9.
2009: Taisuke Tomita
Secretase inhibitors and modulators for Alzheimer's disease treatment.
Expert review of neurotherapeutics 2009;9(5):661-79.
2009: Haipeng Cheng; Kulandaivelu S Vetrivel; Renaldo C Drisdel; Xavier Meckler; Ping Gong; Jae Yoon Leem; Tong Li; Meghan Carter; Ying Chen; Phuong Nguyen; Takeshi Iwatsubo; Taisuke Tomita; Philip C Wong; William N Green; Maria Z Kounnas; Gopal Thinakaran
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
The Journal of biological chemistry 2009;284(3):1373-84.
2008: Taisuke Tomita
[Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease].
Rinshō shinkeigaku = Clinical neurology 2008;48(11):907-9.
2008: King-Ho Cheung; Diana Shineman; Marioly Müller; César Cárdenas; Lijuan Mei; Jun Yang; Taisuke Tomita; Takeshi Iwatsubo; Virginia M-Y Lee; J Kevin Foskett
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.
Neuron 2008;58(6):871-83.
2008: Chihiro Sato; Shizuka Takagi; Taisuke Tomita; Takeshi Iwatsubo
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(24):6264-71.
2008: Taisuke Tomita
At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism.
Naunyn-Schmiedeberg's archives of pharmacology 2008;377(4-6):295-300.
2008: Keiki Kumano; Shigeo Masuda; Masataka Sata; Toshiki Saito; Suk-Young Lee; Mamiko Sakata-Yanagimoto; Taisuke Tomita; Takeshi Iwatsubo; Hideaki Natsugari; Mineo Kurokawa; Seishi Ogawa; Shigeru Chiba
Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.
Pigment cell & melanoma research 2008;21(1):70-8.
2007: Haruhiko Fuwa; Yasuko Takahashi; Yu Konno; Naoto Watanabe; Hiroyuki Miyashita; Makoto Sasaki; Hideaki Natsugari; Toshiyuki Kan; Tohru Fukuyama; Taisuke Tomita; Takeshi Iwatsubo
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors.
ACS chemical biology 2007;2(6):408-18.
2007: Toshiyuki Kan; Yoichi Kita; Yuichi Morohashi; Yusuke Tominari; Shinnosuke Hosoda; Taisuke Tomita; Hideaki Natsugari; Takeshi Iwatsubo; Tohru Fukuyama
Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.
Organic letters 2007;9(11):2055-8.
2007: Noriko Isoo; Chihiro Sato; Hiroyuki Miyashita; Mitsuru Shinohara; Nobumasa Takasugi; Yuichi Morohashi; Shoji Tsuji; Taisuke Tomita; Takeshi Iwatsubo
Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.
The Journal of biological chemistry 2007;282(17):12388-96.
2006: Toshinori Ozaki; Yuanyuan Li; Hironobu Kikuchi; Taisuke Tomita; Takeshi Iwatsubo; Akira Nakagawara
The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.
Biochemical and biophysical research communications 2006;351(1):57-63.
2006: Helen Hsieh; Jannic Boehm; Chihiro Sato; Takeshi Iwatsubo; Taisuke Tomita; Sangram S Sisodia; Roberto Malinow
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.
Neuron 2006;52(5):831-43.
2006: Chihiro Sato; Yuichi Morohashi; Taisuke Tomita; Takeshi Iwatsubo
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(46):12081-8.
2006: Haruhiko Fuwa; Kenichi Hiromoto; Yasuko Takahashi; Satoshi Yokoshima; Toshiyuki Kan; Tohru Fukuyama; Takeshi Iwatsubo; Taisuke Tomita; Hideaki Natsugari
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(16):4184-9.
2006: Yasuko Takahashi; Haruhiko Fuwa; Akane Kaneko; Makoto Sasaki; Satoshi Yokoshima; Hifumi Koizumi; Tohru Takebe; Toshiyuki Kan; Takeshi Iwatsubo; Taisuke Tomita; Hideaki Natsugari; Tohru Fukuyama
Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
Bioorganic & medicinal chemistry letters 2006;16(14):3813-6.
2006: Cédrik Garino; Taisuke Tomita; Nicolas Pietrancosta; younes laras; Roselyne Rosas; Gaëtan Herbette; Bernard Maigret; Gilles Quéléver; Takeshi Iwatsubo; Jean-Louis Kraus
Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.
Journal of medicinal chemistry 2006;49(14):4275-85.
2006: Yuichi Morohashi; Toshiyuki Kan; Yusuke Tominari; Haruhiko Fuwa; Yumiko Okamura; Naoto Watanabe; Chihiro Sato; Hideaki Natsugari; Tohru Fukuyama; Takeshi Iwatsubo; Taisuke Tomita
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).
The Journal of biological chemistry 2006;281(21):14670-6.
2006: Toshihiko Ogura; Kazuhiro Mio; Ikuo Hayashi; Hiroyuki Miyashita; Rie Fukuda; Raphael Kopan; Tatsuhiko Kodama; Takao Hamakubo; Takeshi Iwatsubo; Takeshi Iwastubo; Taisuke Tomita; Chikara Sato
Three-dimensional structure of the gamma-secretase complex.
Biochemical and biophysical research communications 2006;343(2):525-34.
2006: Preston C Keller; Taisuke Tomita; Ikuo Hayashi; Dilip Chandu; Jason D. Weber; David Cistola; Raphael Kopan
A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates.
Biochemistry 2006;45(16):5351-8.
2006: Taisuke Tomita; Sayaka Tanaka; Yuichi Morohashi; Takeshi Iwatsubo
Presenilin-dependent intramembrane cleavage of ephrin-B1.
Molecular neurodegeneration 2006;1():2.
2006: Xudong Yang; Taisuke Tomita; Mary Wines-Samuelson; Vassilios Beglopoulos; Malú G Tansey; Raphael Kopan; Jie Shen
Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord.
Developmental neuroscience 2006;28(1-2):102-17.
2006: Taisuke Tomita; Takeshi Iwatsubo
gamma-secretase as a therapeutic target for treatment of Alzheimer's disease.
Current pharmaceutical design 2006;12(6):661-70.
2005: Naoto Watanabe; Taisuke Tomita; Chihiro Sato; Toshio Kitamura; Yuichi Morohashi; Takeshi Iwatsubo
Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.
The Journal of biological chemistry 2005;280(51):41967-75.
2005: Toshihiro Takeda; Michio Asahi; Osamu Yamaguchi; Shungo Hikoso; Hiroyuki Nakayama; Yoichiro Kusakari; Makoto Kawai; Kenichi Hongo; Yoshiharu Higuchi; Kazunori Kashiwase; Tetsuya Watanabe; Masako Taniike; Atsuko Nakai; Kazuhiko Nishida; Satoshi Kurihara; Dorit B Donoviel; alan bernstein; Taisuke Tomita; Takeshi Iwatsubo; Masatsugu Hori; Kinya Otsu
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2069-71.
2005: Yasuomi Urano; Ikuo Hayashi; Noriko Isoo; Patrick C Reid; Yoshikazu Shibasaki; Noriko Noguchi; Taisuke Tomita; Takeshi Iwatsubo; Takao Hamakubo; Tatsuhiko Kodama
Association of active gamma-secretase complex with lipid rafts.
Journal of lipid research 2005;46(5):904-12.
2005: Manabu Niimura; Noriko Isoo; Nobumasa Takasugi; Makiko Tsuruoka; Kumiko Ui-Tei; Kaoru Saigo; Yuichi Morohashi; Taisuke Tomita; Takeshi Iwatsubo
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.
The Journal of biological chemistry 2005;280(13):12967-75.
2004: Ikuo Hayashi; Yasuomi Urano; Ryouichi Fukuda; Noriko Isoo; Tatsuhiko Kodama; Takao Hamakubo; Taisuke Tomita; Takeshi Iwatsubo
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles.
The Journal of biological chemistry 2004;279(36):38040-6.
2004: Taisuke Tomita; Takeshi Iwatsubo
[Recent advances in Alzheimer's disease-related gamma-secretase complex].
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(7):666-70.
2004: Taisuke Tomita; Takeshi Iwatsubo
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease.
Drug news & perspectives 2004;17(5):321-5.
2004: Masaoki Kawasumi; Tomohiro Chiba; Marina Yamada; Makiko Miyamae-Kaneko; Masaaki Matsuoka; Jin Nakahara; Taisuke Tomita; Takeshi Iwatsubo; Shigeaki Kato; Sadakazu Aiso; Ikuo Nishimoto; Keisuke Kouyama
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
The European journal of neuroscience 2004;19(10):2826-38.
2004: Toshiyuki Kan; Yusuke Tominari; Kentaro Rikimaru; Yuichi Morohashi; Hideaki Natsugari; Taisuke Tomita; Takeshi Iwatsubo; Tohru Fukuyama
Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.
Bioorganic & medicinal chemistry letters 2004;14(8):1983-5.
2004: Hiroko Matsubayashi; Sonoka Sese; Jong-Seo Lee; Tadaoki Shirakawa; Takeshi Iwatsubo; Taisuke Tomita; Shin-ichi Yanagawa
Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference.
Molecular and cellular biology 2004;24(5):2012-24.
2003: Eric H Schroeter; Ma Xenia G Ilagan; Anne L Brunkan; Silva Hecimovic; Yueming Li; Min Xu; Huw D Lewis; Meera T Saxena; Bart De Strooper; Archie Coonrod; Taisuke Tomita; Takeshi Iwatsubo; Chad L Moore; Alison Goate; Michael S Wolfe; Mark S Shearman; Raphael Kopan
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13075-80.
2003: Yoichiro Abe; Keisuke Kouyama; Taisuke Tomita; Yusuke Tomita; Norimitsu Ban; Mikiro Nawa; Masaaki Matsuoka; Takako Niikura; Sadakazu Aiso; Yoshiko Kita; Takeshi Iwatsubo; Ikuo Nishimoto
Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8513-25.
2003: Toshiyuki Kan; Yusuke Tominari; Yuichi Morohashi; Hideaki Natsugari; Taisuke Tomita; Takeshi Iwatsubo; Tohru Fukuyama
Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups.
Chemical communications (Cambridge, England) 2003;(17):2244-5.
2003: Yasuko Takahashi; Ikuo Hayashi; Yusuke Tominari; Kentaro Rikimaru; Yuichi Morohashi; Toshiyuki Kan; Hideaki Natsugari; Tohru Fukuyama; Taisuke Tomita; Takeshi Iwatsubo
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.
The Journal of biological chemistry 2003;278(20):18664-70.
2003: Flavio Kamenetz; Taisuke Tomita; Helen Hsieh; Guy Seabrook; David R Borchelt; Takeshi Iwatsubo; Sangram S Sisodia; Roberto Malinow
APP processing and synaptic function.
Neuron 2003;37(6):925-37.
2003: Nobumasa Takasugi; Taisuke Tomita; Ikuo Hayashi; Makiko Tsuruoka; Manabu Niimura; Yasuko Takahashi; Gopal Thinakaran; Takeshi Iwatsubo
The role of presenilin cofactors in the gamma-secretase complex.
Nature 2003;422(6930):438-41.
2003: Daizo Murakami; Isamu Okamoto; Osamu Nagano; Yoshiaki Kawano; Taisuke Tomita; Takeshi Iwatsubo; Bart De Strooper; Eiji Yumoto; Hideyuki Saya
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.
Oncogene 2003;22(10):1511-6.
2002: Nobumasa Takasugi; Yasuko Takahashi; Yuichi Morohashi; Taisuke Tomita; Takeshi Iwatsubo
The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.
The Journal of biological chemistry 2002;277(51):50198-205.
2002: Masayasu Okochi; Harald Steiner; Akio Fukumori; Hisashi Tanii; Taisuke Tomita; Toshihisa Tanaka; Takeshi Iwatsubo; Takashi Kudo; Masatoshi Takeda; Christian Haass
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
The EMBO journal 2002;21(20):5408-16.
2002: Jae Yoon Leem; Carlos A Saura; Claus U Pietrzik; John C Christianson; Christian P Wanamaker; LaShaunda T King; Margaret L Veselits; Taisuke Tomita; Laura Gasparini; Takeshi Iwatsubo; Huaxi Xu; William N Green; Edward H Koo; Gopal Thinakaran
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
Neurobiology of disease 2002;11(1):64-82.
2002: Taisuke Tomita; Ryohei Katayama; Rie Takikawa; Takeshi Iwatsubo
Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.
FEBS letters 2002;520(1-3):117-21.
2002: Yuichi Morohashi; Noriyuki Hatano; Susumu Ohya; Rie Takikawa; Tomonari Watabiki; Nobumasa Takasugi; Yuji Imaizumi; Taisuke Tomita; Takeshi Iwatsubo
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.
The Journal of biological chemistry 2002;277(17):14965-75.
2001: Taisuke Tomita; T Watabiki; Rie Takikawa; Yuichi Morohashi; Nobumasa Takasugi; R Kopan; Bart De Strooper; Takeshi Iwatsubo
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins.
The Journal of biological chemistry 2001;276(35):33273-81.
2001: Yasuhiro Yamaguchi; Shigetomo Fukuhara; Takashi Nagase; Taisuke Tomita; S Hitomi; Satoshi Kimura; Hiroki Kurihara; Yasuyoshi Ouchi
A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle.
The Journal of biological chemistry 2001;276(34):31510-4.
2001: Taisuke Tomita; Takashi Nagase
[Defensins as a mechanism of host defense and innate immunity].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2001;38(4):440-3.
2001: H Iwata; Taisuke Tomita; Kei Maruyama; Takeshi Iwatsubo
Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.
The Journal of biological chemistry 2001;276(24):21678-85.
2001: Keiro Shirotani; Satoshi Tsubuki; Nobuhisa Iwata; Yoshie Takaki; W Harigaya; K Maruyama; S Kiryu-Seo; H Kiyama; H Iwata; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
The Journal of biological chemistry 2001;276(24):21895-901.
2001: Susumu Ohya; Y Morohashi; Katsuhiko Muraki; Taisuke Tomita; Minoru Watanabe; Takeshi Iwatsubo; Yuji Imaizumi
Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2.
Biochemical and biophysical research communications 2001;282(1):96-102.
2000: Masaaki Takahashi; Sylvain Dore; Christopher D Ferris; Taisuke Tomita; Akira Sawa; H Wolosker; David R Borchelt; Takeshi Iwatsubo; Seong-Hun Kim; Gopal Thinakaran; Sangram S Sisodia; Solomon H Snyder
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Neuron 2000;28(2):461-73.
2000: Carlos A Saura; Taisuke Tomita; Salvador Soriano; M Takahashi; Jae Yoon Leem; T Honda; Edward H Koo; Takeshi Iwatsubo; Gopal Thinakaran
The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.
The Journal of biological chemistry 2000;275(22):17136-42.
2000: K Maruyama; Mihoko Usami; Fuyuki Kametani; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido; Hiroshi Mori; S Ishiura
Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain.
International journal of molecular medicine 2000;5(3):269-73.
2000: Taisuke Tomita; S Hitomi; Takashi Nagase; H Matsui; T Matsuse; S Kimura; Yasuyoshi Ouchi
Effect of ions on antibacterial activity of human beta defensin 2.
Microbiology and immunology 2000;44(9):749-54.
1999: Taisuke Tomita; Rie Takikawa; A Koyama; Yuichi Morohashi; Nobumasa Takasugi; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(24):10627-34.
1999: Taisuke Tomita; Takeshi Iwatsubo
[Molecular cell biology of presenilins].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114(6):337-46.
1999: N Okamura; Hiroyuki Arai; M Higuchi; M Tashiro; Toshifumi Matsui; M Itoh; Takeshi Iwatsubo; Taisuke Tomita; Hidetada Sasaki
Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans.
Neuroscience letters 1999;273(3):203-7.
1999: Harald Steiner; karen duff; Anja Capell; H Romig; MG Grim; Sarah J Lincoln; John Hardy; X Yu; M Picciano; K Fechteler; Martin Citron; R Kopan; B Pesold; S Keck; Miriam Baader; Taisuke Tomita; Takeshi Iwatsubo; Ralf Baumeister; Christian Haass
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: H Fukumoto; Taisuke Tomita; H Matsunaga; Y Ishibashi; Takaomi C Saido; Takeshi Iwatsubo
Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42.
Neuroreport 1999;10(14):2965-9.
1999: Kazutoshi Nishiyama; Bruce D Trapp; T Ikezu; Richard M Ransohoff; Taisuke Tomita; Takeshi Iwatsubo; I Kanazawa; Karen K. Hsiao Ashe; Michael P Lisanti; T Okamoto
Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(15):6538-48.
1999: Carlos A Saura; Taisuke Tomita; F Davenport; CL Harris; Takeshi Iwatsubo; Gopal Thinakaran
Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
The Journal of biological chemistry 1999;274(20):13818-23.
1999: Ohoshi Murayama; Taisuke Tomita; N Nihonmatsu; Miyuki Murayama; X Sun; T Honda; Takeshi Iwatsubo; Akihiko Takashima
Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.
Neuroscience letters 1999;265(1):61-3.
1998: S Naruse; Gopal Thinakaran; JJ Luo; John W Kusiak; Taisuke Tomita; Takeshi Iwatsubo; X Qian; David D Ginty; Donald L Price; David R Borchelt; Philip C Wong; Sangram S Sisodia
Effects of PS1 deficiency on membrane protein trafficking in neurons.
Neuron 1998;21(5):1213-21.
1998: Takeshi Iwatsubo; Taisuke Tomita
[Genetic factors in the pathogenesis of Alzheimer's disease: roles of beta-amyloid and presenilins].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(13):1963-72.
1998: Pang-hsien Tu; James E Galvin; M Baba; Benoit I Giasson; Taisuke Tomita; Susan Leight; S Nakajo; Takeshi Iwatsubo; John Q Trojanowski; Virginia M-Y Lee
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.
Annals of neurology 1998;44(3):415-22.
1998: Taisuke Tomita; S Tokuhiro; Tadafumi Hashimoto; K Aiba; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
The Journal of biological chemistry 1998;273(33):21153-60.
1998: Fumitaka Oyama; N Sawamura; K Kobayashi; Maho Morishima-Kawashima; T Kuramochi; Mie Ito; Taisuke Tomita; Kei Maruyama; Takaomi C Saido; Takeshi Iwatsubo; Anja Capell; Jochen Walter; J Grünberg; Yoshito Ueyama; Christian Haass; Yasuo Ihara
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry 1998;71(1):313-22.
1998: K Shinozaki; Kei Maruyama; H Kume; Taisuke Tomita; Takaomi C Saido; Takeshi Iwatsubo; Kunihiko Obata
The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.
International journal of molecular medicine 1998;1(5):797-9.
1998: M Baba; S Nakajo; Pang-hsien Tu; Taisuke Tomita; K Nakaya; Virginia M-Y Lee; John Q Trojanowski; Takeshi Iwatsubo
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
The American journal of pathology 1998;152(4):879-84.
1998: Taisuke Tomita; T Y Chang; Tsunenori Kodama; Takeshi Iwatsubo
BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes.
Neuroreport 1998;9(5):911-3.
1998: S Tokuhiro; Taisuke Tomita; H Iwata; T Kosaka; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.
Biochemical and biophysical research communications 1998;244(3):751-5.
1997: Taisuke Tomita; Kei Maruyama; Takaomi C Saido; H Kume; K Shinozaki; S Tokuhiro; Anja Capell; Jochen Walter; J Grünberg; Christian Haass; Takeshi Iwatsubo; Kunihiko Obata
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2025-30.
1996: Kei Maruyama; Taisuke Tomita; K Shinozaki; H Kume; H Asada; Takaomi C Saido; S Ishiura; Takeshi Iwatsubo; Kunihiko Obata
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
Biochemical and biophysical research communications 1996;227(3):730-5.
1996: H Kume; Kei Maruyama; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido; Kunihiko Obata
Molecular cloning of a novel basic helix-loop-helix protein from the rat brain.
Biochemical and biophysical research communications 1996;219(2):526-30.