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Wasif Khan

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Chemicals & Drugs

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Agammaglobulinemia

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Publications

TOP 3
Thomas R Malek; Wasif Khan
IL-2: fine-tuning the germinal center reaction.
Wasif Khan
Colonel Bruton's kinase defined the molecular basis of X-linked agammaglobulinemia, the first primary immunodeficiency.
Saravana K Kanagavelu; Sachin Gupta; Wasif Khan; Victoria Snarsky; Richard S Kornbluth; Suzanne Barzee; James M Termini; Jacqueline A Wright; Geoffrey Stone
Soluble multi-trimeric TNF superfamily ligand adjuvants enhance immune responses to a HIV-1 Gag DNA vaccine.

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All Publications

2012: Thomas R Malek; Wasif Khan
IL-2: fine-tuning the germinal center reaction.
Immunity 2012;36(5):702-4.
2012: Wasif Khan
Colonel Bruton's kinase defined the molecular basis of X-linked agammaglobulinemia, the first primary immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(7):2933-5.
2012: Saravana K Kanagavelu; Sachin Gupta; Wasif Khan; Victoria Snarsky; Richard S Kornbluth; Suzanne Barzee; James M Termini; Jacqueline A Wright; Geoffrey Stone
Soluble multi-trimeric TNF superfamily ligand adjuvants enhance immune responses to a HIV-1 Gag DNA vaccine.
Vaccine 2012;30(4):691-702.
2009: Peggy L Kendall; Daniel Moore; Chrys Hulbert; Kristen L Hoek; Wasif Khan; James W Thomas
Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6403-12.
2009: Kristen L Hoek; Gianluca Carlesso; Emily S Clark; Wasif Khan
Absence of mature peripheral B cell populations in mice with concomitant defects in B cell receptor and BAFF-R signaling.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5630-43.
2009: Wasif Khan
B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3561-7.
2009: Yiqin Zuo; Patricia G Yancey; Iris Castro; Wasif Khan; Wasif Khan; Masaru Motojima; Iekuni Ichikawa; Agnes B Fogo; MacRae F Linton; Sergio Fazio; Valentina Kon
Renal dysfunction potentiates foam cell formation by repressing ABCA1.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1277-82.
2009: Iris Castro; Jacqueline A Wright; Bazarragchaa Damdinsuren; Kristen L Hoek; Gianluca Carlesso; Nicholas P Shinners; Rachel M Gerstein; Robert T Woodland; RANJAN SEN; Wasif Khan
B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7729-37.
2009: Ilaria Tassi; Marina Cella; Iris Castro; Susan Gilfillan; Wasif Khan; Marco COLONna
Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization.
European journal of immunology 2009;39(5):1369-78.
2008: Shang Cao; Gianluca Carlesso; Anna B Osipovich; Joan Llanes; Qing Lin; Kristen L Hoek; Wasif Khan; H Earl Ruley
Subunit 1 of the prefoldin chaperone complex is required for lymphocyte development and function.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):476-84.
2007: Nicholas P Shinners; Gianluca Carlesso; Iris Castro; Kristen L Hoek; Radiah A Corn; Robert T Woodland; Robert L Woodland; Martin L Scott; Demin Wang; Wasif Khan
Bruton's tyrosine kinase mediates NF-kappa B activation and B cell survival by B cell-activating factor receptor of the TNF-R family.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3872-80.
2007: Sean M Hartig; Rachel R Greene; Gianluca Carlesso; James N Higginbotham; Wasif Khan; Ales Prokop; Jeffrey M Davidson
Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells.
Biomaterials 2007;28(26):3843-55.
2007: Laura S Treml; Gianluca Carlesso; Kristen L Hoek; Jason E Stadanlick; Taku Kambayashi; Richard J Bram; Michael P Cancro; Wasif Khan
TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7531-9.
2007: Pierre Antony; Kristen L Hoek; Bhaskarjyoti Sarmah; Wasif Khan
Micro-scale flow cytometry-based and biochemical analysis of lipid signaling in primary B cell subpopulations.
Biological procedures online 2007;9():73-83.
2006: Kristen L Hoek; Pierre Antony; John Lowe; Nicholas P Shinners; Bhaskarjyoti Sarmah; Susan R Wente; Demin Wang; Rachel M Gerstein; Wasif Khan
Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5405-13.
2006: Francoise I Bussiere; Rupesh Chaturvedi; Mohammad Asim; Kristen L Hoek; Yulan Cheng; Justin Gainor; Adina Scholz; Wasif Khan; Keith T Wilson
Low multiplicity of infection of Helicobacter pylori suppresses apoptosis of B lymphocytes.
Cancer research 2006;66(13):6834-42.
2005: Arlene E Kray; Robert S Carter; Kevin N Pennington; Gomez J Rey; Laura E Sanders; Joan M Llanes; Wasif Khan; Dean W Ballard; Brian E Wadzinski
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.
The Journal of biological chemistry 2005;280(43):35974-82.
2004: Pierre Antony; James B Petro; Gianluca Carlesso; Nicholas P Shinners; John Lowe; Wasif Khan
B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol.
Biochemical Society transactions 2004;32(Pt 1):113-5.
2003: Pierre Antony; James B Petro; Gianluca Carlesso; Nicholas P Shinners; John Lowe; Wasif Khan
B cell receptor directs the activation of NFAT and NF-kappaB via distinct molecular mechanisms.
Experimental cell research 2003;291(1):11-24.
2002: James B Petro; Rachel M Gerstein; John Lowe; Robert S Carter; Nicholas P Shinners; Wasif Khan
Transitional type 1 and 2 B lymphocyte subsets are differentially responsive to antigen receptor signaling.
The Journal of biological chemistry 2002;277(50):48009-19.
2002: James B Petro; Iris Castro; John Lowe; Wasif Khan
Bruton's tyrosine kinase targets NF-kappaB to the bcl-x promoter via a mechanism involving phospholipase C-gamma2 following B cell antigen receptor engagement.
FEBS letters 2002;532(1-2):57-60.
2001: James B Petro; Wasif Khan
Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes.
The Journal of biological chemistry 2001;276(3):1715-9.
2001: Wasif Khan
Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase.
Immunologic research 2001;23(2-3):147-56.
2000: Barry P Sleckman; Wasif Khan; W Xu; Craig H Bassing; Barbara A Malynn; N G Copeland; CG Bardon; T M Breit; L Davidson; E M Oltz; N A Jenkins; J E Berman; Frederick W Alt
Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene.
Molecular and cellular biology 2000;20(12):4405-10.
2000: James B Petro; S M Jamshedur Rahman; Dean W Ballard; Wasif Khan
Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement.
The Journal of experimental medicine 2000;191(10):1745-54.
1998: Anne B Satterthwaite; Clifford A Lowell; Wasif Khan; P Sideras; FW Alt; Owen N Witte
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
The Journal of experimental medicine 1998;188(5):833-44.
1998: Scott B Snapper; Fred S Rosen; Emiko Mizoguchi; P Cohen; Wasif Khan; C H Liu; TL Hagemann; SP Kwan; R Ferrini; L Davidson; Atul K Bhan; Frederick W Alt
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.
Immunity 1998;9(1):81-91.
1998: D Hata; Y Kawakami; N Inagaki; C S Lantz; T Kitamura; Wasif Khan; Mari Maeda-Yamamoto; T Miura; W Han; SE Hartman; L Yao; H Nagai; A E Goldfeld; FW Alt; Stephen J Galli; Owen N Witte; Toshiaki Kawakami
Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.
The Journal of experimental medicine 1998;187(8):1235-47.
1997: Anne B Satterthwaite; Hilde Cheroutre; Wasif Khan; P Sideras; Owen N Witte
Btk dosage determines sensitivity to B cell antigen receptor cross-linking.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13152-7.
1997: Russell R Reid; AP Prodeus; Wasif Khan; T Hsu; Fred S Rosen; Michael C Carroll
Endotoxin shock in antibody-deficient mice: unraveling the role of natural antibody and complement in the clearance of lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):970-5.
1997: Y Kawakami; T Miura; R Bissonnette; D Hata; Wasif Khan; T Kitamura; Mari Maeda-Yamamoto; SE Hartman; L Yao; FW Alt; Toshiaki Kawakami
Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3938-42.
1997: Wasif Khan; A Nilsson; Emiko Mizoguchi; Emanuela Castigli; J Forsell; Atul K Bhan; Raif S Geha; P Sideras; FW Alt
Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40.
International immunology 1997;9(3):395-405.
1995: Wasif Khan; Paschalis Sideras; Fred S Rosen; F W Alt
The role of Bruton's tyrosine kinase in B-cell development and function in mice and man.
Annals of the New York Academy of Sciences 1995;764():27-38.
1995: Wasif Khan; F W Alt; R M Gerstein; Barbara A Malynn; I Larsson; GA Rathbun; L Davidson; S Müller; A B Kantor; L A Herzenberg
Defective B cell development and function in Btk-deficient mice.
Immunity 1995;3(3):283-99.
1994: Paschalis Sideras; S Müller; H Shiels; H Jin; Wasif Khan; L Nilsson; E Parkinson; J D Thomas; Lars Branden; I Larsson
Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5607-17.
1994: S Teglund; A Olsen; Wasif Khan; L Frängsmyr; Sten Hammarström
The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family.
Genomics 1994;23(3):669-84.
1993: Wasif Khan; Sten Hammarström; T Ramos
Expression of antigens of the carcinoembryonic antigen family on B cell lymphomas and Epstein-Barr virus immortalized B cell lines.
International immunology 1993;5(3):265-70.
1992: Wasif Khan; L Frängsmyr; S Teglund; A Israelsson; K Bremer; Sten Hammarström
Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.
Genomics 1992;14(2):384-90.
1992: Wasif Khan; S Teglund; K Bremer; Sten Hammarström
The pregnancy-specific glycoprotein family of the immunoglobulin superfamily: identification of new members and estimation of family size.
Genomics 1992;12(4):780-7.
1991: Wasif Khan; S Hammarström
Biosynthesis of carcinoembryonic antigen (CEA) gene family members expressed in human tumor cell lines: evidence for cleavage of the glycosyl phosphatidyl inositol (GPI) anchor by GPI-PLC and GPI-PLD.
Biochemistry international 1991;25(4):723-31.
1990: F Zoubir; Wasif Khan; Sten Hammarström
Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning.
Biochemical and biophysical research communications 1990;169(1):203-16.
1990: Wasif Khan; Sten Hammarström
Identification of a new carcinoembryonic antigen (CEA) family member in human fetal liver--cloning and sequence determination of pregnancy-specific glycoprotein 7.
Biochemical and biophysical research communications 1990;168(1):214-25.
1989: Wasif Khan; Sten Hammarström
Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS beta G/FL-NCA glycoprotein with a novel domain arrangement.
Biochemical and biophysical research communications 1989;161(2):525-35.
1989: Wasif Khan; A Osterman; Sten Hammarström
Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3332-6.