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Roberta Budriesi

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Alessandra Locatelli; Luciana Marinelli; Matteo Micucci; Ettore Novellino; Santi Mario Spampinato; Alberto Chiarini; Sandro Cosconati; Pierfranco Ioan; Alberto Leoni; Andrea Bedini; Roberta Budriesi
Ligand Based Approach to L-Type Calcium Channel by Imidazo[2,1-b]thiazole-1,4-Dihydropyridines: from Heart Activity to Brain Affinity.
Alberto Chiarini; Patrizia Comandini; Carmela Fimognari; Tullia Gallina Toschi; Pierfranco Ioan; Monia Lenzi; Marco Malaguti; Matteo Micucci; Roberta Budriesi; Silvana Hrelia
Sweet chestnut (Castanea sativa Mill.) bark extract: cardiovascular activity and myocyte protection against oxidative damage.
Pierfranco Ioan; Marco Pierini; Elda Severi; Francesco Sirci; Domenico Spinelli; Alberto Chiarini; Alessia Ciogli; Barbara Cosimelli; Gabriele Cruciani; Francesco Gasparrini; Roberta Budriesi; Emanuele Carosati
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects.

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All Publications

2013: Alessandra Locatelli; Luciana Marinelli; Matteo Micucci; Ettore Novellino; Santi Mario Spampinato; Alberto Chiarini; Sandro Cosconati; Pierfranco Ioan; Alberto Leoni; Andrea Bedini; Roberta Budriesi
Ligand Based Approach to L-Type Calcium Channel by Imidazo[2,1-b]thiazole-1,4-Dihydropyridines: from Heart Activity to Brain Affinity.
Journal of medicinal chemistry 2013;56(10):3866-77.
2013: Alberto Chiarini; Patrizia Comandini; Carmela Fimognari; Tullia Gallina Toschi; Pierfranco Ioan; Monia Lenzi; Marco Malaguti; Matteo Micucci; Roberta Budriesi; Silvana Hrelia
Sweet chestnut (Castanea sativa Mill.) bark extract: cardiovascular activity and myocyte protection against oxidative damage.
Oxidative medicine and cellular longevity 2013;2013():471790.
2012: Pierfranco Ioan; Marco Pierini; Elda Severi; Francesco Sirci; Domenico Spinelli; Alberto Chiarini; Alessia Ciogli; Barbara Cosimelli; Gabriele Cruciani; Francesco Gasparrini; Roberta Budriesi; Emanuele Carosati
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects.
Organic & biomolecular chemistry 2012;10(45):8994-9003.
2012: Laura Fumagalli; Marco Gobbi; Matteo Micucci; Marco Pallavicini; Valentina Straniero; Cristiano Bolchi; Roberta Budriesi; Alberto Chiarini; Giuseppe Chiodini; Michael Zagami; Ermanno Valoti
Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.
European journal of medicinal chemistry 2012;58():184-91.
2012: Alessia Catalano; Nicola A Colabufo; Diana Conte Camerino; Annalisa De Palma; Jean-François Desaphy; Antonia Di Mola; Claudio Bruno; Roberta Budriesi; Roberta Carbonara; Alessia Carocci; Carla Ghelardini; Giovanni Lentini; Maria Grazia Perrone; Carlo Franchini
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
Journal of medicinal chemistry 2012;55(3):1418-22.
2012: Rita Aldini; Roberta Budriesi; Monica Cevenini; Alberto Chiarini; Antonia D'Errico-Grigioni; Elena Guidetti; Pierfranco Ioan; Margherita Marocchi; Matteo Micucci; Marco Montagnani; Giulia Roda; Francesca Rosini; Alessandro Sartini; Giuseppe Mazzella
Curcuma longa extract exerts a myorelaxant effect on the ileum and colon in a mouse experimental colitis model, independent of the anti-inflammatory effect.
PloS one 2012;7(9):e44650.
2012: Emanuele Carosati; Alberto Chiarini; Gabriele Cruciani; Pierfranco Ioan; M Micucci; B S Zhorov; F Broccatelli; Roberta Budriesi
1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 2): action in other targets and antitargets.
Current medicinal chemistry 2012;19(25):4306-23.
2011: Barbara Cosimelli; Matteo Micucci; Ettore Novellino; Elda Severi; Roberta Budriesi; Mauro Cataldi; Anna Cavaccini; Alberto Chiarini; Pierfranco Ioan
Preliminary finding on a new calcium channel entry blocker chemotype: 5,6-diamino-4-hydroxy-2-mercaptopyrimidine derivatives.
Journal of medicinal chemistry 2011;54(15):5597-601.
2011: Roberta Budriesi; Pierfranco Ioan; Alberto Leoni; Nicoletta Pedemonte; Alessandra Locatelli; Matteo Micucci; Alberto Chiarini; Luis J V Galietta
Cystic fibrosis: a new target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines.
Journal of medicinal chemistry 2011;54(11):3885-94.
2011: Maurizio Viale; Cinzia Cordazzo; Daniela de Totero; Roberta Budriesi; Camillo Rosano; Alberto Leoni; Pierfranco Ioan; Cinzia Aiello; Michela Croce; Aldo Andreani; Mirella Rambaldi; Patrizia Russo; Alberto Chiarini; Domenico Spinelli
Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis.
Investigational new drugs 2011;29(1):98-109.
2011: Pierfranco Ioan; M Micucci; B S Zhorov; F Broccatelli; Emanuele Carosati; Alberto Chiarini; Gabriele Cruciani; Roberta Budriesi
1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs.
Current medicinal chemistry 2011;18(32):4901-22.
2010: Roberta Budriesi; Pierfranco Ioan; Matteo Micucci; Ermanno Micucci; Vittorio Limongelli; Alberto Chiarini
Stop Fitan: antispasmodic effect of natural extract of chestnut wood in guinea pig ileum and proximal colon smooth muscle.
Journal of medicinal food 2010;13(5):1104-10.
2010: Bruno Tasso; Roberta Budriesi; Iana Vazzana; Pierfranco Ioan; Matteo Micucci; Federica Novelli; Michele Tonelli; Anna Sparatore; Alberto Chiarini; Fabio Sparatore
Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation.
Journal of medicinal chemistry 2010;53(12):4668-77.
2009: Stefania Butini; Roberta Budriesi; Michel Hamon; Elena Morelli; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Ettore Novellino; Isabella Fiorini; Pierfranco Ioan; Alberto Chiarini; Alfredo Cagnotto; Tiziana Mennini; Claudia Fracasso; S Caccia; Giuseppe Campiani
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
Journal of medicinal chemistry 2009;52(21):6946-50.
2009: Emanuele Carosati; Roberta Budriesi; Pierfranco Ioan; Gabriele Cruciani; Fabio Fusi; Maria Frosini; Simona Saponara; Francesco Gasparrini; Alessia Ciogli; Claudio Villani; Philip J Stephens; Frank J Devlin; Domenico Spinelli; Alberto Chiarini
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker.
Journal of medicinal chemistry 2009;52(21):6637-48.
2009: Elena Morelli; Sandra Gemma; Roberta Budriesi; Giuseppe Campiani; Ettore Novellino; Caterina Fattorusso; Bruno Catalanotti; Salvatore Sanna Coccone; Sindu Ros; Giuseppe Borrelli; Marco Persico; Isabella Fiorini; Vito Nacci; Pierfranco Ioan; Alberto Chiarini; Michel Hamon; Alfredo Cagnotto; Tiziana Mennini; Claudia Fracasso; Milena Colovic; S Caccia; Stefania Butini
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Journal of medicinal chemistry 2009;52(11):3548-62.
2009: Roberta Budriesi; Barbara Cosimelli; Pierfranco Ioan; Maria Paola Ugenti; Emanuele Carosati; Maria Frosini; Fabio Fusi; Raffaella Spisani; Simona Saponara; Gabriele Cruciani; Ettore Novellino; Domenico Spinelli; Alberto Chiarini
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives.
Journal of medicinal chemistry 2009;52(8):2352-62.
2008: Emanuele Carosati; Roberta Budriesi; Pierfranco Ioan; Maria P Ugenti; Maria Frosini; Fabio Fusi; Gaetano Corda; Barbara Cosimelli; Domenico Spinelli; Alberto Chiarini; Gabriele Cruciani
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening.
Journal of medicinal chemistry 2008;51(18):5552-65.
2008: Roberta Budriesi; Pierfranco Ioan; Alessandra Locatelli; Sandro Cosconati; Alberto Leoni; Maria Paola Ugenti; Aldo Andreani; Rosanna Di Toro; Andrea Bedini; santi spampinato; Luciana Marinelli; Ettore Novellino; Alberto Chiarini
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.
Journal of medicinal chemistry 2008;51(6):1592-600.
2007: Iana Vazzana; Roberta Budriesi; Emanuela Terranova; Pierfranco Ioan; Maria Paola Ugenti; Bruno Tasso; Alberto Chiarini; Fabio Sparatore
Novel quinolizidinyl derivatives as antiarrhythmic agents.
Journal of medicinal chemistry 2007;50(2):334-43.
2007: Roberta Budriesi; Barbara Cosimelli; Pierfranco Ioan; Emanuele Carosati; Maria Paola Ugenti; Raffaella Spisani
Diltiazem analogues: the last ten years on structure activity relationships.
Current medicinal chemistry 2007;14(3):279-87.
2006: Marco Pallavicini; Roberta Budriesi; Laura Fumagalli; Pierfranco Ioan; Alberto Chiarini; Cristiano Bolchi; Maria Paola Ugenti; Simona Colleoni; Marco Gobbi; Ermanno Valoti
WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).
Journal of medicinal chemistry 2006;49(24):7140-9.
2006: Matteo Massi; Pierfranco Ioan; Roberta Budriesi; Alberto Chiarini; Beatrice Vitali; Karen Lammers; Paolo Gionchetti; Massimo Campieri; Anthony Lembo; Patrizia Brigidi
Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue.
World journal of gastroenterology : WJG 2006;12(37):5987-94.
2006: Emanuele Carosati; Gabriele Cruciani; Alberto Chiarini; Roberta Budriesi; Pierfranco Ioan; Raffaella Spisani; Domenico Spinelli; Barbara Cosimelli; Fabio Fusi; Maria Frosini; Rosanna Matucci; Francesco Gasparrini; Alessia Ciogli; Philip J Stephens; Frank J Devlin
Calcium channel antagonists discovered by a multidisciplinary approach.
Journal of medicinal chemistry 2006;49(17):5206-16.
2006: Monica Biscardi; Elisabetta Teodori; Roberto Caporale; Roberta Budriesi; Francesca Balestri; Barbara Scappini; Sabrina Gavazzi; Alberto Grossi
Multidrug reverting activity toward leukemia cells in a group of new verapamil analogues with low cardiovascular activity.
Leukemia research 2006;30(1):1-8.
2005: Alessandro Boido; Roberta Budriesi; Caterina Canu Boido; Pierfranco Ioan; Emanuela Terranova; Alberto Chiarini; Fabio Sparatore
Alpha1- and alpha2-adrenoreceptor antagonist profiles of 1- and 2-[omega-(4-arylpiperazin-1-yl)alkyl]-1,2,3-benzotriazoles.
Chemistry & biodiversity 2005;2(10):1290-304.
2005: Roberta Budriesi; Alessandra Bisi; Pierfranco Ioan; Angela Rampa; Silvia Gobbi; Federica Belluti; Lorna Piazzi; Piero Valenti; Alberto Chiarini
1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety.
Bioorganic & medicinal chemistry 2005;13(10):3423-30.
2005: Roberta Budriesi; Emanuele Carosati; Alberto Chiarini; Barbara Cosimelli; Gabriele Cruciani; Pierfranco Ioan; Domenico Spinelli; Raffaella Spisani
A new class of selective myocardial calcium channel modulators. 2. Role of the acetal chain in oxadiazol-3-one derivatives.
Journal of medicinal chemistry 2005;48(7):2445-56.
2005: Silvia Dei; Roberta Budriesi; Paiwan Sudwan; Marta Ferraroni; Alberto Chiarini; Arlette Garnier-Suillerot; Dina Manetti; Cecilia Martelli; Serena Scapecchi; Elisabetta Teodori
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators.
Bioorganic & medicinal chemistry 2005;13(4):985-98.
2003: Alessandra Bisi; Angela Rampa; Roberta Budriesi; Silvia Gobbi; Federica Belluti; Pierfranco Ioan; Ermanno Valoti; Alberto Chiarini; Piero Valenti
Cardiovascular hybrid drugs: new benzazepinone derivatives as bradycardic agents endowed with selective beta1-non-competitive antagonism.
Bioorganic & medicinal chemistry 2003;11(7):1353-61.
2002: Roberta Budriesi; Barbara Cosimelli; Pierfranco Ioan; Camilla Zaira Lanza; Domenico Spinelli; Alberto Chiarini
Cardiovascular characterization of [1,4]thiazino[3,4-c][1,2,4]oxadiazol-1-one derivatives: selective myocardial calcium channel modulators.
Journal of medicinal chemistry 2002;45(16):3475-81.
2002: Michela Rosini; M Gabriele Bixel; Gabriella Marucci; Roberta Budriesi; Michael Krauss; Maria Laura Bolognesi; Anna Minarini; Vincenzo Tumiatti; Ferdinand Hucho; Carlo Melchiorre
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms.
Journal of medicinal chemistry 2002;45(9):1860-78.
2001: Carlo Melchiorre; Maria Laura Bolognesi; Roberta Budriesi; Carla Ghelardini; Alberto Chiarini; Anna Minarini; Michela Rosini; Vincenzo Tumiatti; E J Wade
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.
Journal of medicinal chemistry 2001;44(24):4035-8.
2001: Silvia Dei; Elisabetta Teodori; Arlette Garnier-Suillerot; Fulvio Gualtieri; Serena Scapecchi; Roberta Budriesi; Alberto Chiarini
Structure-activity relationships and optimisation of the selective MDR modulator 2-(3,4-dimethoxyphenyl)-5-(9-fluorenylamino)-2-(methylethyl) pentanenitrile and its N-methyl derivative.
Bioorganic & medicinal chemistry 2001;9(10):2673-82.
2001: Roberta Budriesi; S Cacciaguerra; R D Toro; Maria Laura Bolognesi; Alberto Chiarini; Anna Minarini; Michela Rosini; santi spampinato; Vincenzo Tumiatti; Carlo Melchiorre
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines.
British journal of pharmacology 2001;132(5):1009-16.
2001: Y Li; K Popaj; M Lochner; H Geneste; Roberta Budriesi; Alberto Chiarini; Carlo Melchiorre; Manfred Hesse
Analogues of polyamine alkaloids and their synthetic advantages.
Farmaco (Società chimica italiana : 1989) 2001;56(1-2):127-31.
1999: Michela Rosini; Roberta Budriesi; M Gabriele Bixel; Maria Laura Bolognesi; Alberto Chiarini; Ferdinand Hucho; P Krogsgaard-Larsen; Ian R Mellor; Anna Minarini; Vincenzo Tumiatti; Peter N R Usherwood; Carlo Melchiorre
Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.
Journal of medicinal chemistry 1999;42(25):5212-23.
1999: Maria Laura Bolognesi; Roberta Budriesi; Andrea Cavalli; Alberto Chiarini; Roberto Gotti; Amedeo Leonardi; Anna Minarini; Elena Poggesi; Maurizio Recanatini; Michela Rosini; Vincenzo Tumiatti; Carlo Melchiorre
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
Journal of medicinal chemistry 1999;42(20):4214-24.
1999: Elisabetta Teodori; Silvia Dei; P Quidu; Roberta Budriesi; Alberto Chiarini; Arlette Garnier-Suillerot; Fulvio Gualtieri; Dina Manetti; Maria Novella Romanelli; Serena Scapecchi
Design, synthesis, and in vitro activity of catamphiphilic reverters of multidrug resistance: discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range.
Journal of medicinal chemistry 1999;42(10):1687-97.
1998: Maria Laura Bolognesi; Roberta Budriesi; Alberto Chiarini; Elena Poggesi; Amedeo Leonardi; Carlo Melchiorre
Design, synthesis, and biological activity of prazosin-related antagonists. Role of the piperazine and furan units of prazosin on the selectivity for alpha1-adrenoreceptor subtypes.
Journal of medicinal chemistry 1998;41(24):4844-53.
1998: Roberta Budriesi; Giorgio Aicardi; Gabriele Campana; santi spampinato; A Zaza; Alessandra Bisi; Angela Rampa; Piero Valenti; Alberto Chiarini
Selective cardiodepressant activity of fluodipine, a fluorenone-1,4-dihydropyridine derivative.
European journal of pharmacology 1998;359(2-3):161-70.
1998: Carlo Melchiorre; Vincenza Andrisano; Maria Laura Bolognesi; Roberta Budriesi; Andrea Cavalli; Vanni Cavrini; Michela Rosini; Vincenzo Tumiatti; Maurizio Recanatini
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
Journal of medicinal chemistry 1998;41(22):4186-9.
1998: Maria Laura Bolognesi; Anna Minarini; Roberta Budriesi; S Cacciaguerra; Alberto Chiarini; santi spampinato; Vincenzo Tumiatti; Carlo Melchiorre
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.
Journal of medicinal chemistry 1998;41(21):4150-60.
1998: Anna Minarini; Roberta Budriesi; Alberto Chiarini; Amedeo Leonardi; Carlo Melchiorre
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
Bioorganic & medicinal chemistry letters 1998;8(11):1353-8.
1998: Piero Valenti; Angela Rampa; Roberta Budriesi; Alessandra Bisi; Alberto Chiarini
Coumarin 1,4-dihydropyridine derivatives.
Bioorganic & medicinal chemistry 1998;6(6):803-10.
1998: Carlo Melchiorre; Maria Laura Bolognesi; Roberta Budriesi; Alberto Chiarini; Dario Giardinà; Anna Minarini; Wilma Quaglia; Amedeo Leonardi
Search for selective antagonists at alpha 1-adrenoreceptors: neutral or negative antagonism?
Farmaco (Società chimica italiana : 1989) 1998;53(4):278-86.
1996: Alberto Chiarini; Angela Rampa; Roberta Budriesi; Alessandra Bisi; G Fabbri; Piero Valenti
1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine.
Bioorganic & medicinal chemistry 1996;4(10):1629-35.
1996: Alessandra Bisi; Roberta Budriesi; Angela Rampa; G Fabbri; Alberto Chiarini; Piero Valenti
Synthesis and pharmacological profile of some chloroxanthone-1, 4-dihydropyridine derivatives.
Arzneimittel-Forschung 1996;46(9):848-51.
1996: Giuseppe Campiani; Isabella Fiorini; M P De Filippis; S M Ciani; Antonio Garofalo; Vito Nacci; Gianluca Giorgi; A Sega; Maurizio Botta; Alberto Chiarini; Roberta Budriesi; Giancarlo Bruni; M R Romeo; C Manzoni; Tiziana Mennini
Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.
Journal of medicinal chemistry 1996;39(15):2922-38.
1996: Roberta Budriesi; Angela Rampa; Alessandra Bisi; G Fabbri; Alberto Chiarini; Piero Valenti
Structure-activity relationship studies of xanthone and fluorenone-1,4-dihydropyridine-5-phosphonates.
Arzneimittel-Forschung 1996;46(4):374-7.
1995: Giuseppe Campiani; Antonio Garofalo; Isabella Fiorini; Maurizio Botta; Vito Nacci; Andrea Tafi; Alberto Chiarini; Roberta Budriesi; Giancarlo Bruni; M R Romeo
Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity.
Journal of medicinal chemistry 1995;38(22):4393-410.
1995: Angela Rampa; Roberta Budriesi; Alessandra Bisi; G Fabbri; P L Barili; Alberto Chiarini; Piero Valenti
Structure-activity relationship studies in the field of calcium antagonists. Xanthone 1,4-dihydropyridines bearing a 2,3-lactone ring.
Arzneimittel-Forschung 1995;45(9):957-62.
1995: Alberto Chiarini; Roberta Budriesi; M L Bolognesi; Anna Minarini; Carlo Melchiorre
In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors.
British journal of pharmacology 1995;114(7):1507-17.
1995: Roberta Budriesi; Angela Rampa; Alessandra Bisi; G Fabbri; Alberto Chiarini; Piero Valenti
Synthesis and pharmacological characterization of some benzazepinone derivatives.
Arzneimittel-Forschung 1995;45(3):234-9.
1995: Maurizio Recanatini; Vincenzo Tumiatti; Roberta Budriesi; Alberto Chiarini; P Sabatino; M L Bolognesi; Carlo Melchiorre
Synthesis, muscarinic blocking activity and molecular modeling studies of 4-DAMP-related compounds.
Bioorganic & medicinal chemistry 1995;3(3):267-77.
1995: Carlo Melchiorre; Anna Minarini; Roberta Budriesi; Alberto Chiarini; santi spampinato; Vincenzo Tumiatti
The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists.
Life sciences 1995;56(11-12):837-44.
1995: Alberto Gasco; Giuseppe Ermondi; A Gasco; Roberta Budriesi; Alberto Chiarini
1,4-Dihydropyridines containing R-NNO-azoxy moieties.
Farmaco (Società chimica italiana : 1989) 1995;50(1):61-4.
1994: Anna Minarini; M L Bolognesi; Roberta Budriesi; Marco Canossa; Alberto Chiarini; santi spampinato; Carlo Melchiorre
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines.
Journal of medicinal chemistry 1994;37(20):3363-72.
1994: Maria Novella Romanelli; Silvia Dei; Serena Scapecchi; Elisabetta Teodori; Fulvio Gualtieri; Roberta Budriesi; Raimund Mannhold
Semi-rigid analogues of the calcium antagonist verapamil: a molecular modelling study.
Journal of computer-aided molecular design 1994;8(2):123-34.
1993: Alessandra Bisi; Roberta Budriesi; Alberto Chiarini; Angela Rampa; Piero Valenti
SAR studies in the field of Ca-antagonists: 2-substituted 1,4-dihydropyridines with a xanthone backbone.
Farmaco (Società chimica italiana : 1989) 1993;48(11):1491-502.
1993: Pier Giovanni Baraldi; Laura Garuti; Alberto Leoni; Barbara Cacciari; Roberta Budriesi; Alberto Chiarini
Synthesis and cardiodepressant activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pentatomic-heteroaryl)-3,5-pyridine-dicarbo xylates. 2.
Drug design and discovery 1993;10(4):319-29.
1992: Angela Rampa; Roberta Budriesi; Alessandra Bisi; Alberto Chiarini; Piero Valenti
Fluorenone and benzophenone 1,4-dihydropyridine derivatives with cardiodepressant activity.
Arzneimittel-Forschung 1992;42(11):1284-7.
1992: Maurizio Recanatini; Anna Minarini; Carlo Melchiorre; Roberta Budriesi; M L Bolognesi
Affinity and selectivity at M2 and M3 muscarinic receptor subtypes of cyclic and oxygenated analogues of 4-DAMP.
Farmaco (Società chimica italiana : 1989) 1992;47(9):1133-47.
1992: A M Gasco; Roberta Fruttero; Giovanni Sorba; Alberto Gasco; Roberta Budriesi; Alberto Chiarini
Synthesis and cardiovascular properties of furazanyl-1,4-dihydropyridines and of furoxanyl analogues.
Arzneimittel-Forschung 1992;42(7):921-5.
1992: Alberto Chiarini; Angela Rampa; Alessandra Bisi; Roberta Budriesi; Piero Valenti
Negative inotropic and chronotropic activity of calcium channel ligands possessing a xanthone 1,4-dihydropyridine backbone.
Arzneimittel-Forschung 1992;42(6):797-801.
1992: Laura Garuti; A Ferranti; Marinella Roberti; E Katz; Roberta Budriesi; Alberto Chiarini
Synthesis and biological evaluation of some new phosphonates.
Die Pharmazie 1992;47(4):295-7.
1991: Anna Minarini; Roberta Budriesi; Alberto Chiarini; Carlo Melchiorre; Vincenzo Tumiatti
Further investigation on methoctramine-related tetraamines: effects of terminal N-substitution and of chain length separating the four nitrogens on M2 muscarinic receptor blocking activity.
Farmaco (Società chimica italiana : 1989) 1991;46(10):1167-78.
1991: Maria Novella Romanelli; Elisabetta Teodori; Serena Scapecchi; Silvia Dei; Roberta Budriesi; Alberto Chiarini
Synthesis and cardiovascular properties of fluorenyl derivatives related to verapamil.
Farmaco (Società chimica italiana : 1989) 1991;46(10):1121-38.
1991: Angela Rampa; Alberto Chiarini; Alessandra Bisi; Roberta Budriesi; Piero Valenti
4-heterotricyclic substituted 1,4-dihydropyridines with a potent selective bradycardic effect.
Arzneimittel-Forschung 1991;41(7):705-9.
1990: Alberto Chiarini; Anna Minarini; Roberta Budriesi; Carlo Melchiorre
Molecular properties of the histamine H2-receptor. Covalent inhibition by tetraamine disulfides.
Farmaco (Società chimica italiana : 1989) 1990;45(9):1001-11.
1990: Piero Valenti; Alberto Chiarini; F Gasperi; Roberta Budriesi
Xanthone 1,4-dihydropyridine derivatives with a potent selective bradycardic effect.
Arzneimittel-Forschung 1990;40(2 Pt 1):122-5.
1989: Cristina Bellucci; Fulvio Gualtieri; Serena Scapecchi; Elisabetta Teodori; Roberta Budriesi; Alberto Chiarini
Negative inotropic and calcium antagonistic activity of alkyl and arylalkyl phosphonates.
Farmaco (Società chimica italiana : 1989) 1989;44(12):1167-91.