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Rudi Beyaert

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Kelly Verhelst; Lynn Verstrepen; Isabelle Carpentier; Rudi Beyaert
IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer.
Conor Mc Guire; David Muylaert; Marco Prinz; Rudi Beyaert; Lynn Elton; Peter Wieghofer; Geert Van Loo
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.
Marlies Galle; Isabelle Carpentier; Rudi Beyaert
Structure and function of the Type III secretion system of Pseudomonas aeruginosa.

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All Publications

2013: Kelly Verhelst; Lynn Verstrepen; Isabelle Carpentier; Rudi Beyaert
IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer.
Biochemical pharmacology 2013;85(7):873-80.
2013: Conor Mc Guire; David Muylaert; Marco Prinz; Rudi Beyaert; Lynn Elton; Peter Wieghofer; Geert Van Loo
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2896-903.
2012: Marlies Galle; Isabelle Carpentier; Rudi Beyaert
Structure and function of the Type III secretion system of Pseudomonas aeruginosa.
Current protein & peptide science 2012;13(8):831-42.
2012: Ezra Aksoy; Inma Berenjeno-Martin; Rudi Beyaert; Sandrine Delbauve; Alain Filloux; Veronique Flamand; Abderrahman Hachani; Gemma Nock; Wayne P Pearce; Salma Taboubi; David Torres; Maria A Whitehead; Bart Vanhaesebroeck
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Nature immunology 2012;13(11):1045-54.
2012: Yuanyuan Chu; Laura Glockner; Daniel Krappmann; Ramin Massoumi; Valeria Soberon; Geert Van Loo; Rudi Beyaert; Marc Schmidt-Supprian
A20 and CYLD do not share significant overlapping functions during B cell development and activation.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(9):4437-43.
2012: Kelly Verhelst; Lynn Verstrepen; Isabelle Carpentier; Ivan Dikic; Tobias Kensche; Marja M Kreike; Laura Meloni; Rudi Beyaert
A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7.
The EMBO journal 2012;31(19):3845-55.
2012: Monique Willart; Bart N Lambrecht; Philippe Pouliot; Rudi Beyaert; Harald Braun; Kim Deswarte; Hamida Hammad
Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
The Journal of experimental medicine 2012;209(8):1505-17.
2012: Lynn Verstrepen; Rudi Beyaert
No ubiquitin anchors and fully RIGged.
Immunity 2012;36(6):897-9.
2012: Jens Staal; Rudi Beyaert
A two-step activation mechanism of MALT1 paracaspase.
Journal of molecular biology 2012;419(1-2):1-3.
2012: Jonathan Maelfait; Rudi Beyaert
Emerging role of ubiquitination in antiviral RIG-I signaling.
Microbiology and molecular biology reviews : MMBR 2012;76(1):33-45.
2012: Celia Bovijn; Dominiek Catteeuw; Anne-Sophie De Smet; Jan Tavernier; Peter Ulrichts; Rudi Beyaert; Frank Peelman
Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.
The Journal of biological chemistry 2012;287(6):4088-98.
2012: Marlies Galle; Mira Haegman; Shouguang Jin; Peter Vandenabeele; Pieter Bogaert; Rudi Beyaert
The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection.
PloS one 2012;7(7):e41547.
2012: Jonathan Maelfait; Manolis Pasparakis; Kenny Roose; Xavier Saelens; Mozes Sze; Geert Van Loo; Pieter Bogaert; Isabelle Carpentier; Rudi Beyaert
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.
PLoS pathogens 2012;8(3):e1002570.
2011: Conor Mc Guire; Rudi Beyaert; Geert Van Loo
Death receptor signalling in central nervous system inflammation and demyelination.
Trends in neurosciences 2011;34(12):619-28.
2011: Saskia Lippens; M L Mikkola; Manolis Pasparakis; Mozes Sze; Rudi Beyaert; Wim Declercq; M Devos; Barbara Gilbert; C Guérin; C Mc Guire; S Lefebvre; Peter Vandenabeele; L Vereecke; K Verhelst; Geert Van Loo
Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis.
Cell death and differentiation 2011;18(12):1845-53.
2011: Kelly Verhelst; Lynn Verstrepen; Isabelle Carpentier; Rudi Beyaert
Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not.
Biochemical pharmacology 2011;82(9):1057-65.
2011: Samar Abdulkhalek; Schammim Ray Amith; Rudi Beyaert; Trisha Finlay; Susan L Franchuk; Katrina Gee; Alanna Gilmour; Merry Guo; Christina Guzzo; Preethi Jayanth; Myron R Szewczuk
Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling.
The Journal of biological chemistry 2011;286(42):36532-49.
2011: Lars Vereecke; Rudi Beyaert; Geert Van Loo
Enterocyte death and intestinal barrier maintenance in homeostasis and disease.
Trends in molecular medicine 2011;17(10):584-93.
2011: Mourad Matmati; Patrick Matthys; Manolis Pasparakis; Marc Schmidt-Supprian; Steven Staelens; Mozes Sze; Lars Vereecke; Eveline Verheugen; Conor Mc Guire; Rudi Beyaert; Louis Boon; Yuanyuan Chu; Dirk Elewaut; Lies Geboes; Peggy Jacques; Mirjam Kool; Bart N Lambrecht; Els Louagie; Jonathan Maelfait; Geert Van Loo
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.
Nature genetics 2011;43(9):908-12.
2011: Lars Vereecke; Rudi Beyaert; Geert Van Loo
Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.
Biochemical Society transactions 2011;39(4):1086-91.
2011: Rudi Beyaert
SHP works a double shift to control TLR signaling.
Nature immunology 2011;12(8):725-7.
2011: Mirjam Kool; Rudi Beyaert; Filipe Branco-Madeira; Sofie De Prijck; Dirk Elewaut; Hamida Hammad; Sophie Janssens; Femke Muskens; Boris Reizis; Mozes Sze; Geert Van Loo; Jens van Praet; Wim Waelput; Bart N Lambrecht
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.
Immunity 2011;35(1):82-96.
2011: Lynn Verstrepen; Isabelle Carpentier; Kelly Verhelst; Rudi Beyaert
TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond.
Trends in biochemical sciences 2011;36(7):347-54.
2011: Jens Staal; Yasmine Driege; Tine Bekaert; A Demeyer; David Muyllaert; Petra Van Damme; Kris Gevaert; Rudi Beyaert
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.
The EMBO journal 2011;30(9):1742-52.
2011: Yuanyuan Chu; J Christoph Vahl; Dilip Kumar; Klaus Heger; Arianna Bertossi; Edyta Wójtowicz; Valeria Soberon; Dominik Schenten; Brigitte Mack; Miriam Reutelshöfer; Rudi Beyaert; Kerstin Amann; Geert van Loo; Marc Schmidt-Supprian
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice.
Blood 2011;117(7):2227-36.
2011: Sandra Gardam; Rudi Beyaert
The kinase NIK as a therapeutic target in multiple myeloma.
Expert opinion on therapeutic targets 2011;15(2):207-18.
2011: Geert Van Loo; Rudi Beyaert
Negative regulation of NF-κB and its involvement in rheumatoid arthritis.
Arthritis research & therapy 2011;13(3):221.
2011: Jens Staal; Tine Bekaert; Rudi Beyaert
Regulation of NF-κB signaling by caspases and MALT1 paracaspase.
Cell research 2011;21(1):40-54.
2010: Conor Mc Guire; Thomas Volckaert; Uta Wolke; Mozes Sze; Riet de Rycke; Ari Waisman; Marco Prinz; Rudi Beyaert; Manolis Pasparakis; Geert Van Loo
Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7646-53.
2010: Lynn Verstrepen; Kelly Verhelst; Geert Van Loo; Isabelle Carpentier; Steven C Ley; Rudi Beyaert
Expression, biological activities and mechanisms of action of A20 (TNFAIP3).
Biochemical pharmacology 2010;80(12):2009-20.
2010: Sandra De Boever; E A Neirinckx; Evelyne Meyer; Siegrid De Baere; Rudi Beyaert; Patrick De Backer; Siska Croubels
Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens.
Journal of veterinary pharmacology and therapeutics 2010;33(6):564-72.
2010: Claire Malinverni; Adeline Unterreiner; Jens Staal; Annelies Demeyer; Marion Galaup; Marcel Luyten; Rudi Beyaert; Frédéric Bornancin
Cleavage by MALT1 induces cytosolic release of A20.
Biochemical and biophysical research communications 2010;400(4):543-7.
2010: Trisha M Finlay; Samar Abdulkhalek; Alanna Gilmour; Christina Guzzo; Preethi Jayanth; Schammim Ray Amith; Katrina Gee; Rudi Beyaert; Myron R Szewczuk
Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo.
Glycoconjugate journal 2010;27(6):583-600.
2010: Lars Vereecke; Mozes Sze; Conor Mc Guire; Brecht Rogiers; Yuanyuan Chu; Marc Schmidt-Supprian; Manolis Pasparakis; Rudi Beyaert; Geert Van Loo
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.
The Journal of experimental medicine 2010;207(7):1513-23.
2010: Stuart Bloor; Jonathan Maelfait; Rebekka Krumbach; Rudi Beyaert; Felix Randow
Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):6970-5.
2010: Trisha M Finlay; Preethi Jayanth; Schammim Ray Amith; Alanna Gilmour; Christina Guzzo; Katrina Gee; Rudi Beyaert; Myron R Szewczuk
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.
Glycoconjugate journal 2010;27(3):329-48.
2010: Noelia Fradejas; María Dolores Pastor; Miguel Burgos; Rudi Beyaert; Pedro Tranque; Soledad Calvo
Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C/EBP homologous protein.
Journal of neuroscience research 2010;88(5):1094-105.
2010: Geert Van Loo; Mozes Sze; Nadia Bougarne; Jelle Praet; Conor Mc Guire; Andrea Ullrich; Guy Haegeman; Marco Prinz; Rudi Beyaert; Karolien De Bosscher
Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis.
Molecular endocrinology (Baltimore, Md.) 2010;24(2):310-22.
2010: Schammim Ray Amith; Preethi Jayanth; Susan Franchuk; Trisha Finlay; Volkan Seyrantepe; Rudi Beyaert; Alexey V Pshezhetsky; Myron R Szewczuk
Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling.
Cellular signalling 2010;22(2):314-24.
2010: Peter Ulrichts; Celia Bovijn; Sam Lievens; Rudi Beyaert; Jan Tavernier; Frank Peelman
Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site.
Journal of cell science 2010;123(Pt 2):256-65.
2010: Claudia Hoffmann; Marlies Galle; Sabrina Dilling; Rina Käppeli; Andreas J Müller; Pascal Songhet; Rudi Beyaert; Wolf-Dietrich Hardt
In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin.
PloS one 2010;5(8):e12477.
2009: Schammim Ray Amith; Preethi Jayanth; Susan Franchuk; Sarah Siddiqui; Volkan Seyrantepe; Katrina Gee; Sameh Basta; Rudi Beyaert; Alexey V Pshezhetsky; Myron R Szewczuk
Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase.
Glycoconjugate journal 2009;26(9):1197-212.
2009: Lieven Huang; Patrick De Baetselier; Rudi Beyaert
Targeting the EGF receptor ectodomain in the context of cancer.
Expert opinion on therapeutic targets 2009;13(11):1347-61.
2009: Sandra De Boever; Siska Croubels; E Meyer; Stanislas U Sys; Rudi Beyaert; Richard Ducatelle; Patrick De Backer
Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens.
Avian pathology : journal of the W.V.P.A 2009;38(5):403-11.
2009: Andreas J Müller; Claudia Hoffmann; Marlies Galle; Aeke Van Den Broeke; Mathias Heikenwalder; Laura Falter; Benjamin Misselwitz; Marcus Kremer; Rudi Beyaert; Wolf-Dietrich Hardt
The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation.
Cell host & microbe 2009;6(2):125-36.
2009: Lars Vereecke; Rudi Beyaert; Geert Van Loo
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology.
Trends in immunology 2009;30(8):383-91.
2009: Lynn Verstrepen; Isabelle Carpentier; Kelly Verhelst; Rudi Beyaert
ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.
Biochemical pharmacology 2009;78(2):105-14.
2009: Katrien Van Der Kelen; Rudi Beyaert; Dirk Inzé; Lieven De Veylder
Translational control of eukaryotic gene expression.
Critical reviews in biochemistry and molecular biology 2009;44(4):143-68.
2009: Beatrice Coornaert; Isabelle Carpentier; Rudi Beyaert
A20: central gatekeeper in inflammation and immunity.
The Journal of biological chemistry 2009;284(13):8217-21.
2009: Karine Breckpot; Cindy Aerts-Toegaert; Carlo Heirman; Uschi Peeters; Rudi Beyaert; Joeri L Aerts; Kris Thielemans
Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):860-70.
2009: Kelly Verhelst; Lynn Verstrepen; Beatrice Coornaert; Isabelle Carpentier; Rudi Beyaert
Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation.
Methods in molecular biology (Clifton, N.J.) 2009;517():205-15.
2009: Peter Ulrichts; Irma Lemmens; Delphine Lavens; Rudi Beyaert; Jan Tavernier
MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling.
Methods in molecular biology (Clifton, N.J.) 2009;517():133-44.
2008: Jonathan Maelfait; Rudi Beyaert
Non-apoptotic functions of caspase-8.
Biochemical pharmacology 2008;76(11):1365-73.
2008: L Huang; L Verstrepen; K Heyninck; Andy Wullaert; Hilde Revets; Patrick De Baetselier; Rudi Beyaert
ABINs inhibit EGF receptor-mediated NF-kappaB activation and growth of EGF receptor-overexpressing tumour cells.
Oncogene 2008;27(47):6131-40.
2008: Isabelle Carpentier; Beatrice Coornaert; Rudi Beyaert
Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation.
Biochemical and biophysical research communications 2008;374(4):752-7.
2008: L Verstrepen; T Bekaert; T-L Chau; J Tavernier; A Chariot; Rudi Beyaert
TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme.
Cellular and molecular life sciences : CMLS 2008;65(19):2964-78.
2008: Jonathan Maelfait; Elisabeth Vercammen; Sophie Janssens; Peter Schotte; Mira Haegman; Stefan Magez; Rudi Beyaert
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.
The Journal of experimental medicine 2008;205(9):1967-73.
2008: M Galle; P Schotte; Mira Haegman; A Wullaert; H J Yang; S Jin; Rudi Beyaert
The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation.
Journal of cellular and molecular medicine 2008;12(5A):1767-76.
2008: E Vercammen; Jens Staal; A Van Den Broeke; Mira Haegman; L Vereecke; Peter Schotte; Rudi Beyaert
Prolonged exposure to IL-1beta and IFNgamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappaB/NO-dependent mechanism.
Oncogene 2008;27(27):3780-8.
2008: Sebastian Wagner; I Carpentier; Vladimir V Rogov; M Kreike; F Ikeda; F Löhr; C-J Wu; J D Ashwell; Volker Dötsch; Ivan Dikic; Rudi Beyaert
Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.
Oncogene 2008;27(26):3739-45.
2008: Tieu-Lan Chau; Romain Gioia; Jean-Stéphane Gatot; Félicia Patrascu; Isabelle Carpentier; Jean-Paul Chapelle; Luke O'Neill; Rudi Beyaert; Jacques Piette; Alain Chariot
Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?
Trends in biochemical sciences 2008;33(4):171-80.
2008: Beatrice Coornaert; Mathijs Baens; Karen Heyninck; Tine Bekaert; Mira Haegman; Jens Staal; Lijun Sun; Zhijian J Chen; Peter Marynen; Rudi Beyaert
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
Nature immunology 2008;9(3):263-71.
2008: Hidekatsu Iha; JEAN-MARIE ALAIN PELOPONESE; Lynn Verstrepen; Grzegorz Zapart; Fumiyo Ikeda; C Dahlem Smith; Matthew F Starost; Venkat R K Yedavalli; Karen Heyninck; Ivan Dikic; Rudi Beyaert; Kuan-Teh Jeang
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.
The EMBO journal 2008;27(4):629-41.
2008: Sandra De Boever; Rudi Beyaert; Fréderic Vandemaele; Katleen Baert; L Duchateau; Bruno Goddeeris; Patrick De Backer; Siska Croubels
The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens.
Avian pathology : journal of the W.V.P.A 2008;37(1):39-44.
2008: Elisabeth Vercammen; Jens Staal; Rudi Beyaert
Sensing of viral infection and activation of innate immunity by toll-like receptor 3.
Clinical microbiology reviews 2008;21(1):13-25.
2008: Lynn Verstrepen; Minou Adib-Conquy; Marja M Kreike; Isabelle Carpentier; Christophe Adrie; Jean-Marc Cavaillon; Rudi Beyaert
Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB.
Journal of cellular and molecular medicine 2008;12(1):316-29.
2007: Peggy Papeleu; Andy Wullaert; Greetje Elaut; Tom Henkens; Mathieu Vinken; Georges Laus; Dirk Tourwé; Rudi Beyaert; Vera Rogiers; Tamara Vanhaecke
Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes.
Cell proliferation 2007;40(5):640-55.
2007: Andy Wullaert; Geert Van Loo; Karen Heyninck; Rudi Beyaert
Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond.
Endocrine reviews 2007;28(4):365-86.
2007: Reinout Schauvliege; Sophie Janssens; Rudi Beyaert
Pellino proteins: novel players in TLR and IL-1R signalling.
Journal of cellular and molecular medicine 2007;11(3):453-61.
2007: Heidi Noels; Geert Van Loo; Sofie Hagens; Vicky Broeckx; Rudi Beyaert; Peter Marynen; Mathijs Baens
A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions.
The Journal of biological chemistry 2007;282(14):10180-9.
2007: Peter Ulrichts; Frank Peelman; Rudi Beyaert; Jan Tavernier
MAPPIT analysis of TLR adaptor complexes.
FEBS letters 2007;581(4):629-36.
2007: Bert Schepens; Sandrine A Tinton; Yanik Bruynooghe; Eef Parthoens; Mira Haegman; Rudi Beyaert; Sigrid Cornelis
A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis.
The EMBO journal 2007;26(1):158-69.
2007: Andy Wullaert; Lynn Verstrepen; Sofie Van Huffel; Minou Adib-Conquy; Sigrid Cornelis; Marja M Kreike; Mira Haegman; Karim El Bakkouri; Matthew Sanders; Kelly Verhelst; Isabelle Carpentier; Jean-Marc Cavaillon; Karen Heyninck; Rudi Beyaert
LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation.
The Journal of biological chemistry 2007;282(1):81-90.
2006: Andy Wullaert; Karen Heyninck; Sophie Janssens; Rudi Beyaert
Ubiquitin: tool and target for intracellular NF-kappaB inhibitors.
Trends in immunology 2006;27(11):533-40.
2006: Andy Wullaert; Karen Heyninck; Rudi Beyaert
Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.
Biochemical pharmacology 2006;72(9):1090-101.
2006: Minou Adib-Conquy; Christophe Adrie; Catherine Fitting; olivier gattolliat; Rudi Beyaert; Jean-Marc Cavaillon
Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients.
Critical care medicine 2006;34(9):2377-85.
2006: Reinout Schauvliege; Sophie Janssens; Rudi Beyaert
Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.
FEBS letters 2006;580(19):4697-702.
2006: Karen Heyninck; Rudi Beyaert
A novel link between Lck, Bak expression and chemosensitivity.
Oncogene 2006;25(12):1693-5.
2006: Marianne Bonif; Marie-Alice Meuwis; Pierre Close; Valérie Benoit; Karen Heyninck; Jean-Paul Chapelle; Vincent Bours; Marie-Paule Merville; Jacques Piette; Rudi Beyaert; Alain Chariot
TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation.
The Biochemical journal 2006;394(Pt 3):593-603.
2005: Andy Wullaert; Ben Wielockx; Sofie Van Huffel; Veerle Bogaert; Bruno G De Geest; Peggy Papeleu; Peter Schotte; Karim El Bakkouri; Karen Heyninck; Claude Libert; Rudi Beyaert
Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality.
Hepatology (Baltimore, Md.) 2005;42(2):381-9.
2005: Karim El Bakkouri; Andy Wullaert; Mira Haegman; Karen Heyninck; Rudi Beyaert
Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model.
The Journal of biological chemistry 2005;280(18):17938-44.
2005: Sigrid Cornelis; Yanik Bruynooghe; Geert Van Loo; Xavier Saelens; Peter Vandenabeele; Rudi Beyaert
Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1.
Oncogene 2005;24(9):1552-62.
2005: Bert Schepens; Sandrine A Tinton; Yanik Bruynooghe; Rudi Beyaert; Sigrid Cornelis
The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia.
Nucleic acids research 2005;33(21):6884-94.
2005: Sigrid Cornelis; Sandrine A Tinton; Bert Schepens; Yanik Bruynooghe; Rudi Beyaert
UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein.
Nucleic acids research 2005;33(10):3095-108.
2005: Karen Heyninck; Rudi Beyaert
A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions.
Trends in biochemical sciences 2005;30(1):1-4.
2005: Sandrine A Tinton; Bert Schepens; Yanik Bruynooghe; Rudi Beyaert; Sigrid Cornelis
Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
The Biochemical journal 2005;385(Pt 1):155-63.
2004: Isabelle Carpentier; B Coornaert; Rudi Beyaert
Function and regulation of tumor necrosis factor receptor type 2.
Current medicinal chemistry 2004;11(16):2205-12.
2004: Peter Schotte; Geertrui Denecker; Aeke Van Den Broeke; Peter Vandenabeele; Guy R Cornelis; Rudi Beyaert
Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta.
The Journal of biological chemistry 2004;279(24):25134-42.
2004: Bert De Klerck; Isabelle Carpentier; Rik J U Lories; Yvette Habraken; Jacques Piette; Geert Carmeliet; Rudi Beyaert; An D Billiau; Patrick Matthys
Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis.
Arthritis research & therapy 2004;6(3):R220-31.
2004: Wim van Criekinge; Peter Schotte; Karen Heyninck; Rudi Beyaert
The yeast three-hybrid system as a tool to study caspases.
Methods in molecular biology (Clifton, N.J.) 2004;282():243-54.
2004: Karen Heyninck; Sofie Van Huffel; Marja M Kreike; Rudi Beyaert
Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20.
Methods in molecular biology (Clifton, N.J.) 2004;282():223-41.
2003: Karen Heyninck; Andy Wullaert; Rudi Beyaert
Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease.
Biochemical pharmacology 2003;66(8):1409-15.
2003: S Janssens; Rudi Beyaert
Role of Toll-like receptors in pathogen recognition.
Clinical microbiology reviews 2003;16(4):637-46.
2003: Sophie Janssens; Kim Burns; Elisabeth Vercammen; Jurg Tschopp; Rudi Beyaert
MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression.
FEBS letters 2003;548(1-3):103-7.
2003: Paul C Evans; Trevor S Smith; Meng-Jiun Lai; Mark G Williams; david burke; Karen Heyninck; Marja M Kreike; Rudi Beyaert; Tom L Blundell; Peter J Kilshaw
A novel type of deubiquitinating enzyme.
The Journal of biological chemistry 2003;278(25):23180-6.
2003: Karen Heyninck; Marja M Kreike; Rudi Beyaert
Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1.
FEBS letters 2003;536(1-3):135-40.
2003: Sophie Janssens; Rudi Beyaert
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members.
Molecular cell 2003;11(2):293-302.
2003: Kimberly Burns; Sophie Janssens; Brian Brissoni; Natalia Olivos; Rudi Beyaert; Jürg Tschopp
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.
The Journal of experimental medicine 2003;197(2):263-8.
2002: Geert Van Loo; Xavier Saelens; Filip Matthijssens; Peter Schotte; Rudi Beyaert; Wim Declercq; Peter Vandenabeele
Caspases are not localized in mitochondria during life or death.
Cell death and differentiation 2002;9(11):1207-11.
2002: Reinout Schauvliege; Jill Vanrobaeys; Peter Schotte; Rudi Beyaert
Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1.
The Journal of biological chemistry 2002;277(44):41624-30.
2002: Sophie Janssens; Rudi Beyaert
A universal role for MyD88 in TLR/IL-1R-mediated signaling.
Trends in biochemical sciences 2002;27(9):474-82.
2002: Jutte van der Werff Ten Bosch; Peter Schotte; Alina Ferster; Nadira Azzi; Thomas Boehler; Geneviève Laurey; Mikko Arola; Christian Demanet; Rudi Beyaert; Kris Thielemans; Jacques Otten
Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations.
British journal of haematology 2002;117(1):176-88.
2002: Sophie Janssens; Kim Burns; Jurg Tschopp; Rudi Beyaert
Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88.
Current biology : CB 2002;12(6):467-71.
2002: Geert Van Loo; Hans Demol; Maria van Gurp; Bart Hoorelbeke; Peter Schotte; Rudi Beyaert; B Zhivotovsky; Kris Gevaert; Wim Declercq; Joël Vandekerckhove; Peter Vandenabeele
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid.
Cell death and differentiation 2002;9(3):301-8.
2002: Rudi Beyaert; Geert Van Loo; Karen Heyninck; Peter Vandenabeele
Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.
International review of cytology 2002;214():225-72.
2001: Geert Van Loo; Peter Schotte; Maria van Gurp; Hans Demol; Bart Hoorelbeke; Kris Gevaert; ivan rodriguez; A Ruiz-Carrillo; Joël Vandekerckhove; Wim Declercq; Rudi Beyaert; Peter Vandenabeele
Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation.
Cell death and differentiation 2001;8(12):1136-42.
2001: Karen Heyninck; Rudi Beyaert
Crosstalk between NF-kappaB-activating and apoptosis-inducing proteins of the TNF-receptor complex.
Molecular cell biology research communications : MCBRC 2001;4(5):259-65.
2001: Sofie Van Huffel; F Delaei; Karen Heyninck; D De Valck; Rudi Beyaert
Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.
The Journal of biological chemistry 2001;276(32):30216-23.
2001: Paul C Evans; E R Taylor; J Coadwell; Karen Heyninck; Rudi Beyaert; Peter J Kilshaw
Isolation and characterization of two novel A20-like proteins.
The Biochemical journal 2001;357(Pt 3):617-23.
2001: Peter Schotte; Geert Van Loo; Isabelle Carpentier; Peter Vandenabeele; Rudi Beyaert
Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein.
The Journal of biological chemistry 2001;276(28):25939-45.
2001: Peter Schotte; Reinout Schauvliege; Sophie Janssens; Rudi Beyaert
The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide.
The Journal of biological chemistry 2001;276(24):21153-7.
2001: M Klinkenberg; Sofie Van Huffel; Karen Heyninck; Rudi Beyaert
Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions.
FEBS letters 2001;498(1):93-7.
2001: Thomas Wieder; Frank Essmann; A Prokop; Karin Schmelz; Klaus Schulze-Osthoff; Rudi Beyaert; Bernd Dörken; Peter Daniel
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.
Blood 2001;97(5):1378-87.
2001: M Vandermeeren; S Janssens; H Wouters; I Borghmans; Marcel Borgers; Rudi Beyaert; Johan JGH Geysen
Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-kappa B1, but not RelA in normal human dermal fibroblast cells.
The Journal of investigative dermatology 2001;116(1):124-30.
2000: Rudi Beyaert; Karen Heyninck; Sofie Van Huffel
A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis.
Biochemical pharmacology 2000;60(8):1143-51.
2000: Sigrid Cornelis; Yanik Bruynooghe; Geertrui Denecker; Sofie Van Huffel; Sandrine A Tinton; Rudi Beyaert
Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.
Molecular cell 2000;5(4):597-605.
2000: Katharina D'Herde; B De Prest; Sylvie Mussche; Peter Schotte; Rudi Beyaert; R V Coster; Frank Roels
Ultrastructural localization of cytochrome c in apoptosis demonstrates mitochondrial heterogeneity.
Cell death and differentiation 2000;7(4):331-7.
1999: Walter Fiers; Rudi Beyaert; W Declercq; Peter Vandenabeele
More than one way to die: apoptosis, necrosis and reactive oxygen damage.
Oncogene 1999;18(54):7719-30.
1999: Isabelle Carpentier; Rudi Beyaert
TRAF1 is a TNF inducible regulator of NF-kappaB activation.
FEBS letters 1999;460(2):246-50.
1999: Geert Van Gassen; Chris De Jonghe; Stefan Pype; Wim van Criekinge; Ann Julliams; I Vanderhoeven; S Woodrow; Rudi Beyaert; Danny Huylebroeck; Christine Van Broeckhoven
Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome.
Neurobiology of disease 1999;6(5):376-91.
1999: D De Valck; D Y Jin; Karen Heyninck; M Van de Craen; R Contreras; Walter Fiers; K T Jeang; Rudi Beyaert
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
Oncogene 1999;18(29):4182-90.
1999: Karen Heyninck; Geertrui Denecker; D De Valck; Walter Fiers; Rudi Beyaert
Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20.
Anticancer research 1999;19(4B):2863-8.
1999: Karen Heyninck; D De Valck; Wim Vanden Berghe; Wim van Criekinge; R Contreras; Walter Fiers; Guy Haegeman; Rudi Beyaert
The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.
The Journal of cell biology 1999;145(7):1471-82.
1999: Wim van Criekinge; Sigrid Cornelis; M Van de Craen; Peter Vandenabeele; Walter Fiers; Rudi Beyaert
GAL4 is a substrate for caspases: implications for two-hybrid screening and other GAL4-based assays.
Molecular cell biology research communications : MCBRC 1999;1(2):158-61.
1999: A Rickers; N Peters; Volker Badock; Rudi Beyaert; P Vandenabeele; Bernd Dörken; Kurt Bommert
Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.
European journal of biochemistry / FEBS 1999;261(1):269-74.
1999: Karen Heyninck; Rudi Beyaert
The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6.
FEBS letters 1999;442(2-3):147-50.
1999: Peter Schotte; Wim Declercq; Sofie Van Huffel; Peter Vandenabeele; Rudi Beyaert
Non-specific effects of methyl ketone peptide inhibitors of caspases.
FEBS letters 1999;442(1):117-21.
1999: H Louagie; Peter Schotte; Anne Vral; M Cornelissen; Hubert Thierens; Rudi Beyaert; Leo De Ridder; J Philippe
Apoptosis induced by gamma irradiation in peripheral blood mononuclear cells is not mediated by cytochrome-c release and only partially involves caspase-3-like proteases.
Cell biology international 1999;23(9):611-7.
1998: D De Valck; Dominique Vercammen; Walter Fiers; Rudi Beyaert
Differential activation of phospholipases during necrosis or apoptosis: a comparative study using tumor necrosis factor and anti-Fas antibodies.
Journal of cellular biochemistry 1998;71(3):392-9.
1998: Peter Schotte; Wim van Criekinge; M Van de Craen; Geert Van Loo; M Desmedt; Johan Grooten; M Cornelissen; Leo De Ridder; Joël Vandekerckhove; Walter Fiers; Peter Vandenabeele; Rudi Beyaert
Cathepsin B-mediated activation of the proinflammatory caspase-11.
Biochemical and biophysical research communications 1998;251(1):379-87.
1998: Wim van Criekinge; Maria van Gurp; E Decoster; Peter Schotte; M Van de Craen; Walter Fiers; Peter Vandenabeele; Rudi Beyaert
Use of the yeast three-hybrid system as a tool to study caspases.
Analytical biochemistry 1998;263(1):62-6.
1998: Louis C Penning; Raymond G Schipper; Dominique Vercammen; Albert A J Verhofstad; T Denecker; Rudi Beyaert; Peter Vandenabeele
Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.
Cytokine 1998;10(6):423-31.
1998: Dominique Vercammen; Rudi Beyaert; Geertrui Denecker; Vera Goossens; Geert Van Loo; Wim Declercq; Johan Grooten; Walter Fiers; Peter Vandenabeele
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.
The Journal of experimental medicine 1998;187(9):1477-85.
1998: Isabelle Carpentier; Wim Declercq; NL Malinin; David Wallach; Walter Fiers; Rudi Beyaert
TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways.
FEBS letters 1998;425(2):195-8.
1997: Dominique Vercammen; Peter Vandenabeele; Rudi Beyaert; Wim Declercq; Walter Fiers
Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.
Cytokine 1997;9(11):801-8.
1997: E Decoster; V Vandevoorde; Rudi Beyaert; Guy Haegeman; Walter Fiers
Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.
FEBS letters 1997;416(2):183-6.
1997: D De Valck; Karen Heyninck; Wim van Criekinge; Peter Vandenabeele; Walter Fiers; Rudi Beyaert
A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.
Biochemical and biophysical research communications 1997;238(2):590-4.
1997: Geertrui Denecker; Peter Vandenabeele; Johan Grooten; Louis C Penning; Wim Declercq; Rudi Beyaert; W A Buurman; Walter Fiers
Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.
Cytokine 1997;9(9):631-8.
1997: David Wallach; Mark P Boldin; Eugene E Varfolomeev; Rudi Beyaert; P Vandenabeele; W Fiers
Cell death induction by receptors of the TNF family: towards a molecular understanding.
FEBS letters 1997;410(1):96-106.
1997: R M Barge; R Willemze; Peter Vandenabeele; Walter Fiers; Rudi Beyaert
Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal.
FEBS letters 1997;409(2):207-10.
1997: Rudi Beyaert; Vincent J Kidd; Sigrid Cornelis; M Van de Craen; Geertrui Denecker; Jill Lahti; R Gururajan; Peter Vandenabeele; Walter Fiers
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.
The Journal of biological chemistry 1997;272(18):11694-7.
1997: M Van de Craen; I Van den Brande; Wim Declercq; M Irmler; Rudi Beyaert; J Tschopp; Walter Fiers; Peter Vandenabeele
Cleavage of caspase family members by granzyme B: a comparative study in vitro.
European journal of immunology 1997;27(5):1296-9.
1997: M Van de Craen; Peter Vandenabeele; Wim Declercq; I Van den Brande; Geert Van Loo; F Molemans; Peter Schotte; Wim van Criekinge; Rudi Beyaert; Walter Fiers
Characterization of seven murine caspase family members.
FEBS letters 1997;403(1):61-9.
1996: Wim van Criekinge; Rudi Beyaert; M Van de Craen; Peter Vandenabeele; Peter Schotte; D De Valck; Walter Fiers
Functional characterization of the prodomain of interleukin-1beta-converting enzyme.
The Journal of biological chemistry 1996;271(44):27245-8.
1996: Toshiro Niki; Detlef Schuppan; Pieter De Bleser; R Vrijsen; M Pipeleers-Marichal; Rudi Beyaert; Eddie Wisse; Albert Geerts
Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells.
Hepatology (Baltimore, Md.) 1996;23(6):1673-81.
1996: Rudi Beyaert; A Cuenda; Wim Vanden Berghe; Stephane Plaisance; J C Lee; Guy Haegeman; P Cohen; Walter Fiers
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.
The EMBO journal 1996;15(8):1914-23.
1996: D De Valck; Karen Heyninck; Wim van Criekinge; Roland Contreras; Rudi Beyaert; Walter Fiers
A20, an inhibitor of cell death, self-associates by its zinc finger domain.
FEBS letters 1996;384(1):61-4.
1995: Rudi Beyaert; B Vanhaesebroeck; Wim Declercq; Johan Van Lint; P Vandenabele; Patrizia Agostinis; Jackie R Vandenheede; Walter Fiers
Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis.
The Journal of biological chemistry 1995;270(40):23293-9.
1995: Peter Vandenabeele; Wim Declercq; Rudi Beyaert; W Fiers
Two tumour necrosis factor receptors: structure and function.
Trends in cell biology 1995;5(10):392-9.
1995: Walter Fiers; Rudi Beyaert; Elke Boone; Sigrid Cornelis; Wim Declercq; E Decoster; Geertrui Denecker; B Depuydt; D De Valck; G De Wilde; Vera Goossens; Johan Grooten; Guy Haegeman; Karen Heyninck; Louis C Penning; Stephane Plaisance; Katia Vancompernolle; Wim van Criekinge; Peter Vandenabeele; Wim Vanden Berghe; M Van de Craen; V Vandevoorde; Dominique Vercammen
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Journal of inflammation 1995;47(1-2):67-75.
1994: Peter Vandenabeele; Vera Goossens; Rudi Beyaert; Wim Declercq; Johan Grooten; B Vanhaesebroeck; M Van de Craen; Dominique Vercammen; B Depuydt; Geertrui Denecker
Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity.
Circulatory shock 1994;44(4):196-200.
1994: Rudi Beyaert; Walter Fiers
Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not.
FEBS letters 1994;340(1-2):9-16.
1993: K Schulze-Osthoff; Rudi Beyaert; V Vandevoorde; Guy Haegeman; Walter Fiers
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
The EMBO journal 1993;12(8):3095-104.
1993: Rudi Beyaert; Karen Heyninck; D De Valck; F Boeykens; Frans van Roy; Walter Fiers
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):291-300.
1993: Rudi Beyaert; B Vanhaesebroeck; Karen Heyninck; Elke Boone; D De Valck; K Schulze-Osthoff; Guy Haegeman; Frans van Roy; Walter Fiers
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
Cancer research 1993;53(11):2623-30.
1993: B Vanhaesebroeck; J C Reed; D De Valck; Johan Grooten; T Miyashita; S Tanaka; Rudi Beyaert; Frans van Roy; Walter Fiers
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.
Oncogene 1993;8(4):1075-81.
1993: D De Valck; Rudi Beyaert; Frans van Roy; Walter Fiers
Tumor necrosis factor cytotoxicity is associated with phospholipase D activation.
European journal of biochemistry / FEBS 1993;212(2):491-7.
1992: Rudi Beyaert; K Schulze-Osthoff; Frans van Roy; Walter Fiers
Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: possible role in the triggering and exacerbation of psoriasis by lithium treatment.
European journal of immunology 1992;22(8):2181-4.
1992: K Schulze-Osthoff; A C Bakker; B Vanhaesebroeck; Rudi Beyaert; W A Jacob; Walter Fiers
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
The Journal of biological chemistry 1992;267(8):5317-23.
1991: Rudi Beyaert; K Schulze-Osthoff; Frans van Roy; Walter Fiers
Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression.
Cytokine 1991;3(4):284-91.
1991: B Vanhaesebroeck; S Van Bladel; A Lenaerts; P Suffys; Rudi Beyaert; Rudolf Lucas; Frans van Roy; Walter Fiers
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.
Cancer research 1991;51(9):2469-77.
1991: Rudi Beyaert; Christian R De Potter; B Vanhaesebroeck; Frans van Roy; Walter Fiers
Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride.
The American journal of pathology 1991;138(3):727-39.
1991: P Suffys; Rudi Beyaert; D De Valck; B Vanhaesebroeck; Frans van Roy; Walter Fiers
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.
European journal of biochemistry / FEBS 1991;195(2):465-75.
1990: Frans van Roy; Marc Mareel; K Vleminckx; Rudi Beyaert; Walter Fiers; N Devleeschouwer; C Muquardt; N Legros; Marc Bracke; G Leclercq
Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives.
International journal of cancer. Journal international du cancer 1990;46(3):522-32.
1990: Rudi Beyaert; P Suffys; Frans van Roy; Walter Fiers
Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement.
FEBS letters 1990;262(1):93-6.
1990: B Vanhaesebroeck; E J Cragoe; J Pouysségur; Rudi Beyaert; Frans van Roy; Walter Fiers
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter.
FEBS letters 1990;261(2):319-22.
1990: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaerdt; Johan Grooten; A Lenaerts; Claude Libert; P Suffys; N Takahashi; Jan Tavernier
Tumour necrosis factor: mechanism of action at the molecular, cellular and in vivo level.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1990;202():159.
1989: Rudi Beyaert; B Vanhaesebroeck; P Suffys; Frans van Roy; Walter Fiers
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9494-8.
1989: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells.
Anticancer research 1989;9(1):167-71.
1988: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity.
European journal of biochemistry / FEBS 1988;178(1):257-65.
1988: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaerdt; C Haegeman; P Suffys; Jan Tavernier; B Vanhaesebroeck
TNF: its potential as an antitumour agent.
Developments in biological standardization 1988;69():143-51.
1987: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism.
Biochemical and biophysical research communications 1987;149(2):735-43.
1987: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaerdt; Guy Haegeman; P Suffys; Jan Tavernier; Peter Vandenabeele; B Vanhaesebroeck; X Van Ostade
Gene cloning and structure--function relationship of cytokines such as TNF and interleukins.
Immunology letters 1987;16(3-4):219-26.
1987: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaert; P Suffys; Jan Tavernier; B Van Haesebroeck; Frans van Roy
Tumor necrosis factor: a potential antitumor agent?
Journal of interferon research 1987;7(5):627-34.