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Rudi Beyaert

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
46
Fiers, Walter
31
Heyninck, Karen
26
Vandenabeele, Peter
19
Schotte, Peter
17
van Roy, Frans
14
De Valck, D
14
Declercq, Wim
12
Van Loo, Geert
11
van Criekinge, Wim
10
Van de Craen, M
10
Cornelis, Sigrid
9
Wullaert, Andy
8
Carpentier, Isabelle
8
Denecker, Geertrui
8
Janssens, Sophie

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Publications

TOP 3
Huang Lieven; De Baetselier Patrick; Beyaert Rudi
Targeting the EGF receptor ectodomain in the context of cancer.
Müller Andreas J; Hoffmann Claudia; Galle Marlies; Van Den Broeke Aeke; Heikenwalder Mathias; Falter Laura; Misselwitz Benjamin; Kremer Marcus; Beyaert Rudi; Hardt Wolf-Dietrich
The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation.
Vereecke Lars; Beyaert Rudi; van Loo Geert
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology.

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All Publications

2009: Huang Lieven; De Baetselier Patrick; Beyaert Rudi
Targeting the EGF receptor ectodomain in the context of cancer.
Expert opinion on therapeutic targets 2009;13(11):1347-61.
2009: Müller Andreas J; Hoffmann Claudia; Galle Marlies; Van Den Broeke Aeke; Heikenwalder Mathias; Falter Laura; Misselwitz Benjamin; Kremer Marcus; Beyaert Rudi; Hardt Wolf-Dietrich
The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation.
Cell host & microbe 2009;6(2):125-36.
2009: Vereecke Lars; Beyaert Rudi; van Loo Geert
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology.
Trends in immunology 2009;30(8):383-91.
2009: Van Der Kelen Katrien; Beyaert Rudi; Inzé Dirk; De Veylder Lieven
Translational control of eukaryotic gene expression.
Critical reviews in biochemistry and molecular biology 2009;44(4):143-68.
2009: Verstrepen Lynn; Carpentier Isabelle; Verhelst Kelly; Beyaert Rudi
ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.
Biochemical pharmacology 2009;78(2):105-14.
2009: Coornaert Beatrice; Carpentier Isabelle; Beyaert Rudi
A20: central gatekeeper in inflammation and immunity.
The Journal of biological chemistry 2009;284(13):8217-21.
2009: Breckpot Karine; Aerts-Toegaert Cindy; Heirman Carlo; Peeters Uschi; Beyaert Rudi; Aerts Joeri L; Thielemans Kris
Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):860-70.
2009: Verhelst Kelly; Verstrepen Lynn; Coornaert Beatrice; Carpentier Isabelle; Beyaert Rudi
Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation.
Methods in molecular biology (Clifton, N.J.) 2009;517():205-15.
2009: Ulrichts Peter; Lemmens Irma; Lavens Delphine; Beyaert Rudi; Tavernier Jan
MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling.
Methods in molecular biology (Clifton, N.J.) 2009;517():133-44.
2008: Maelfait Jonathan; Beyaert Rudi
Non-apoptotic functions of caspase-8.
Biochemical pharmacology 2008;76(11):1365-73.
2008: Carpentier Isabelle; Coornaert Beatrice; Beyaert Rudi
Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation.
Biochemical and biophysical research communications 2008;374(4):752-7.
2008: Huang L; Verstrepen L; Heyninck K; Wullaert A; Revets H; De Baetselier P; Beyaert R
ABINs inhibit EGF receptor-mediated NF-kappaB activation and growth of EGF receptor-overexpressing tumour cells.
Oncogene 2008;27(47):6131-40.
2008: Verstrepen L; Bekaert T; Chau T-L; Tavernier J; Chariot A; Beyaert R
TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme.
Cellular and molecular life sciences : CMLS 2008;65(19):2964-78.
2008: Maelfait Jonathan; Vercammen Elisabeth; Janssens Sophie; Schotte Peter; Haegman Mira; Magez Stefan; Beyaert Rudi
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.
The Journal of experimental medicine 2008;205(9):1967-73.
2008: Galle M; Schotte P; Haegman M; Wullaert A; Yang H J; Jin S; Beyaert R
The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation.
Journal of cellular and molecular medicine 2008;12(5A):1767-76.
2008: Vercammen E; Staal J; Van Den Broeke A; Haegman M; Vereecke L; Schotte P; Beyaert R
Prolonged exposure to IL-1beta and IFNgamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappaB/NO-dependent mechanism.
Oncogene 2008;27(27):3780-8.
2008: Wagner S; Carpentier I; Rogov V; Kreike M; Ikeda F; Löhr F; Wu C-J; Ashwell J D; Dötsch V; Dikic I; Beyaert R
Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.
Oncogene 2008;27(26):3739-45.
2008: Chau Tieu-Lan; Gioia Romain; Gatot Jean-Stéphane; Patrascu Félicia; Carpentier Isabelle; Chapelle Jean-Paul; O'Neill Luke; Beyaert Rudi; Piette Jacques; Chariot Alain
Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?
Trends in biochemical sciences 2008;33(4):171-80.
2008: Coornaert Beatrice; Baens Mathijs; Heyninck Karen; Bekaert Tine; Haegman Mira; Staal Jens; Sun Lijun; Chen Zhijian J; Marynen Peter; Beyaert Rudi
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
Nature immunology 2008;9(3):263-71.
2008: Iha Hidekatsu; Peloponese Jean-Marie; Verstrepen Lynn; Zapart Grzegorz; Ikeda Fumiyo; Smith C Dahlem; Starost Matthew F; Yedavalli Venkat; Heyninck Karen; Dikic Ivan; Beyaert Rudi; Jeang Kuan-Teh
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.
The EMBO journal 2008;27(4):629-41.
2008: De Boever S; Beyaert R; Vandemaele F; Baert K; Duchateau L; Goddeeris B; De Backer P; Croubels S
The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens.
Avian pathology : journal of the W.V.P.A 2008;37(1):39-44.
2008: Vercammen Elisabeth; Staal Jens; Beyaert Rudi
Sensing of viral infection and activation of innate immunity by toll-like receptor 3.
Clinical microbiology reviews 2008;21(1):13-25.
2008: Verstrepen Lynn; Adib-Conquy Minou; Kreike Marja; Carpentier Isabelle; Adrie Christophe; Cavaillon Jean-Marc; Beyaert Rudi
Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB.
Journal of cellular and molecular medicine 2008;12(1):316-29.
2007: Papeleu P; Wullaert A; Elaut G; Henkens T; Vinken M; Laus G; Tourwé D; Beyaert R; Rogiers V; Vanhaecke T
Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes.
Cell proliferation 2007;40(5):640-55.
2007: Wullaert Andy; van Loo Geert; Heyninck Karen; Beyaert Rudi
Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond.
Endocrine reviews 2007;28(4):365-86.
2007: Schauvliege Reinout; Janssens Sophie; Beyaert Rudi
Pellino proteins: novel players in TLR and IL-1R signalling.
Journal of cellular and molecular medicine 2007;11(3):453-61.
2007: Noels Heidi; van Loo Geert; Hagens Sofie; Broeckx Vicky; Beyaert Rudi; Marynen Peter; Baens Mathijs
A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions.
The Journal of biological chemistry 2007;282(14):10180-9.
2007: Ulrichts Peter; Peelman Frank; Beyaert Rudi; Tavernier Jan
MAPPIT analysis of TLR adaptor complexes.
FEBS letters 2007;581(4):629-36.
2007: Schepens Bert; Tinton Sandrine A; Bruynooghe Yanik; Parthoens Eef; Haegman Mira; Beyaert Rudi; Cornelis Sigrid
A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis.
The EMBO journal 2007;26(1):158-69.
2007: Wullaert Andy; Verstrepen Lynn; Van Huffel Sofie; Adib-Conquy Minou; Cornelis Sigrid; Kreike Marja; Haegman Mira; El Bakkouri Karim; Sanders Matthew; Verhelst Kelly; Carpentier Isabelle; Cavaillon Jean-Marc; Heyninck Karen; Beyaert Rudi
LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation.
The Journal of biological chemistry 2007;282(1):81-90.
2006: Wullaert Andy; Heyninck Karen; Janssens Sophie; Beyaert Rudi
Ubiquitin: tool and target for intracellular NF-kappaB inhibitors.
Trends in immunology 2006;27(11):533-40.
2006: Wullaert Andy; Heyninck Karen; Beyaert Rudi
Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.
Biochemical pharmacology 2006;72(9):1090-101.
2006: Adib-Conquy Minou; Adrie Christophe; Fitting Catherine; Gattolliat Olivier; Beyaert Rudi; Cavaillon Jean-Marc
Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients.
Critical care medicine 2006;34(9):2377-85.
2006: Schauvliege Reinout; Janssens Sophie; Beyaert Rudi
Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.
FEBS letters 2006;580(19):4697-702.
2006: Bonif Marianne; Meuwis Marie-Alice; Close Pierre; Benoit Valérie; Heyninck Karen; Chapelle Jean-Paul; Bours Vincent; Merville Marie-Paule; Piette Jacques; Beyaert Rudi; Chariot Alain
TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation.
The Biochemical journal 2006;394(Pt 3):593-603.
2006: Heyninck K; Beyaert R
A novel link between Lck, Bak expression and chemosensitivity.
Oncogene 2006;25(12):1693-5.
2005: Wullaert Andy; Wielockx Ben; Van Huffel Sofie; Bogaert Veerle; De Geest Bart; Papeleu Peggy; Schotte Peter; El Bakkouri Karim; Heyninck Karen; Libert Claude; Beyaert Rudi
Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality.
Hepatology (Baltimore, Md.) 2005;42(2):381-9.
2005: El Bakkouri Karim; Wullaert Andy; Haegman Mira; Heyninck Karen; Beyaert Rudi
Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model.
The Journal of biological chemistry 2005;280(18):17938-44.
2005: Cornelis Sigrid; Bruynooghe Yanik; Van Loo Geert; Saelens Xavier; Vandenabeele Peter; Beyaert Rudi
Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1.
Oncogene 2005;24(9):1552-62.
2005: Heyninck Karen; Beyaert Rudi
A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions.
Trends in biochemical sciences 2005;30(1):1-4.
2005: Tinton Sandrine A; Schepens Bert; Bruynooghe Yanik; Beyaert Rudi; Cornelis Sigrid
Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
The Biochemical journal 2005;385(Pt 1):155-63.
2005: Schepens Bert; Tinton Sandrine A; Bruynooghe Yanik; Beyaert Rudi; Cornelis Sigrid
The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia.
Nucleic acids research 2005;33(21):6884-94.
2005: Cornelis Sigrid; Tinton Sandrine A; Schepens Bert; Bruynooghe Yanik; Beyaert Rudi
UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein.
Nucleic acids research 2005;33(10):3095-108.
2004: Carpentier I; Coornaert B; Beyaert R
Function and regulation of tumor necrosis factor type 2.
Current medicinal chemistry 2004;11(16):2205-12.
2004: Schotte Peter; Denecker Geertrui; Van Den Broeke Aeke; Vandenabeele Peter; Cornelis Guy R; Beyaert Rudi
Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta.
The Journal of biological chemistry 2004;279(24):25134-42.
2004: De Klerck Bert; Carpentier Isabelle; Lories Rik J; Habraken Yvette; Piette Jacques; Carmeliet Geert; Beyaert Rudi; Billiau Alfons; Matthys Patrick
Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis.
Arthritis research & therapy 2004;6(3):R220-31.
2004: van Criekinge Wim; Schotte Peter; Heyninck Karen; Beyaert Rudi
The yeast three-hybrid system as a tool to study caspases.
Methods in molecular biology (Clifton, N.J.) 2004;282():243-54.
2004: Heyninck Karen; Van Huffel Sofie; Kreike Marja; Beyaert Rudi
Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20.
Methods in molecular biology (Clifton, N.J.) 2004;282():223-41.
2003: Janssens S; Beyaert R
Role of Toll-like receptors in pathogen recognition.
Clinical microbiology reviews 2003;16(4):637-46.
2003: Heyninck Karen; Wullaert Andy; Beyaert Rudi
Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease.
Biochemical pharmacology 2003;66(8):1409-15.
2003: Janssens Sophie; Burns Kim; Vercammen Elisabeth; Tschopp Jurg; Beyaert Rudi
MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression.
FEBS letters 2003;548(1-3):103-7.
2003: Evans Paul C; Smith Trevor S; Lai Meng-Jiun; Williams Mark G; Burke David F; Heyninck Karen; Kreike Marja M; Beyaert Rudi; Blundell Tom L; Kilshaw Peter J
A novel type of deubiquitinating enzyme.
The Journal of biological chemistry 2003;278(25):23180-6.
2003: Janssens Sophie; Beyaert Rudi
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members.
Molecular cell 2003;11(2):293-302.
2003: Heyninck Karen; Kreike Marja M; Beyaert Rudi
Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1.
FEBS letters 2003;536(1-3):135-40.
2003: Burns Kimberly; Janssens Sophie; Brissoni Brian; Olivos Natalia; Beyaert Rudi; Tschopp Jürg
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.
The Journal of experimental medicine 2003;197(2):263-8.
2002: van Loo G; Saelens X; Matthijssens F; Schotte P; Beyaert R; Declercq W; Vandenabeele P
Caspases are not localized in mitochondria during life or death.
Cell death and differentiation 2002;9(11):1207-11.
2002: Schauvliege Reinout; Vanrobaeys Jill; Schotte Peter; Beyaert Rudi
Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1.
The Journal of biological chemistry 2002;277(44):41624-30.
2002: Janssens Sophie; Beyaert Rudi
A universal role for MyD88 in TLR/IL-1R-mediated signaling.
Trends in biochemical sciences 2002;27(9):474-82.
2002: van der Werff Ten Bosch Jutte; Schotte Peter; Ferster Alice; Azzi Nadira; Boehler Thomas; Laurey Geneviève; Arola Mikko; Demanet Christian; Beyaert Rudi; Thielemans Kris; Otten Jacques
Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations.
British journal of haematology 2002;117(1):176-88.
2002: Janssens Sophie; Burns Kim; Tschopp Jurg; Beyaert Rudi
Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88.
Current biology : CB 2002;12(6):467-71.
2002: Van Loo G; Demol H; van Gurp M; Hoorelbeke B; Schotte P; Beyaert R; Zhivotovsky B; Gevaert K; Declercq W; Vandekerckhove J; Vandenabeele P
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid.
Cell death and differentiation 2002;9(3):301-8.
2002: Beyaert Rudi; Van Loo Geert; Heyninck Karen; Vandenabeele Peter
Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.
International review of cytology 2002;214():225-72.
2001: van Loo G; Schotte P; van Gurp M; Demol H; Hoorelbeke B; Gevaert K; Rodriguez I; Ruiz-Carrillo A; Vandekerckhove J; Declercq W; Beyaert R; Vandenabeele P
Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation.
Cell death and differentiation 2001;8(12):1136-42.
2001: Heyninck K; Beyaert R
Crosstalk between NF-kappaB-activating and apoptosis-inducing proteins of the TNF-receptor complex.
Molecular cell biology research communications : MCBRC 2001;4(5):259-65.
2001: Evans P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J
Isolation and characterization of two novel A20-like proteins.
The Biochemical journal 2001;357(Pt 3):617-23.
2001: Van Huffel S; Delaei F; Heyninck K; De Valck D; Beyaert R
Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.
The Journal of biological chemistry 2001;276(32):30216-23.
2001: Schotte P; Van Loo G; Carpentier I; Vandenabeele P; Beyaert R
Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein.
The Journal of biological chemistry 2001;276(28):25939-45.
2001: Klinkenberg M; Van Huffel S; Heyninck K; Beyaert R
Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions.
FEBS letters 2001;498(1):93-7.
2001: Schotte P; Schauvliege R; Janssens S; Beyaert R
The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide.
The Journal of biological chemistry 2001;276(24):21153-7.
2001: Wieder T; Essmann F; Prokop A; Schmelz K; Schulze-Osthoff K; Beyaert R; Dörken B; Daniel P T
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.
Blood 2001;97(5):1378-87.
2001: Vandermeeren M; Janssens S; Wouters H; Borghmans I; Borgers M; Beyaert R; Geysen J
Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-kappa B1, but not RelA in normal human dermal fibroblast cells.
The Journal of investigative dermatology 2001;116(1):124-30.
2000: Beyaert R; Heyninck K; Van Huffel S
A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis.
Biochemical pharmacology 2000;60(8):1143-51.
2000: Cornelis S; Bruynooghe Y; Denecker G; Van Huffel S; Tinton S; Beyaert R
Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.
Molecular cell 2000;5(4):597-605.
2000: D'Herde K; De Prest B; Mussche S; Schotte P; Beyaert R; Coster R V; Roels F
Ultrastructural localization of cytochrome c in apoptosis demonstrates mitochondrial heterogeneity.
Cell death and differentiation 2000;7(4):331-7.
1999: Fiers W; Beyaert R; Declercq W; Vandenabeele P
More than one way to die: apoptosis, necrosis and reactive oxygen damage.
Oncogene 1999;18(54):7719-30.
1999: Carpentier I; Beyaert R
TRAF1 is a TNF inducible regulator of NF-kappaB activation.
FEBS letters 1999;460(2):246-50.
1999: Van Gassen G; De Jonghe C; Pype S; Van Criekinge W; Julliams A; Vanderhoeven I; Woodrow S; Beyaert R; Huylebroeck D; Van Broeckhoven C
Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome.
Neurobiology of disease 1999;6(5):376-91.
1999: Heyninck K; Denecker G; De Valck D; Fiers W; Beyaert R
Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20.
Anticancer research 1999;19(4B):2863-8.
1999: De Valck D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
Oncogene 1999;18(29):4182-90.
1999: Heyninck K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R
The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.
The Journal of cell biology 1999;145(7):1471-82.
1999: van Criekinge W; Cornelis S; Van De Craen M; Vandenabeele P; Fiers W; Beyaert R
GAL4 is a substrate for caspases: implications for two-hybrid screening and other GAL4-based assays.
Molecular cell biology research communications : MCBRC 1999;1(2):158-61.
1999: Rickers A; Peters N; Badock V; Beyaert R; Vandenabeele P; Dörken B; Bommert K
Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.
European journal of biochemistry / FEBS 1999;261(1):269-74.
1999: Heyninck K; Beyaert R
The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6.
FEBS letters 1999;442(2-3):147-50.
1999: Schotte P; Declercq W; Van Huffel S; Vandenabeele P; Beyaert R
Non-specific effects of methyl ketone peptide inhibitors of caspases.
FEBS letters 1999;442(1):117-21.
1999: Louagie H; Schotte P; Vral A; Cornelissen M; Thierens H; Beyaert R; De Ridder L; Philippe J
Apoptosis induced by gamma irradiation in peripheral blood mononuclear cells is not mediated by cytochrome-c release and only partially involves caspase-3-like proteases.
Cell biology international 1999;23(9):611-7.
1998: De Valck D; Vercammen D; Fiers W; Beyaert R
Differential activation of phospholipases during necrosis or apoptosis: a comparative study using tumor necrosis factor and anti-Fas antibodies.
Journal of cellular biochemistry 1998;71(3):392-9.
1998: Schotte P; Van Criekinge W; Van de Craen M; Van Loo G; Desmedt M; Grooten J; Cornelissen M; De Ridder L; Vandekerckhove J; Fiers W; Vandenabeele P; Beyaert R
Cathepsin B-mediated activation of the proinflammatory caspase-11.
Biochemical and biophysical research communications 1998;251(1):379-87.
1998: Van Criekinge W; van Gurp M; Decoster E; Schotte P; Van de Craen M; Fiers W; Vandenabeele P; Beyaert R
Use of the yeast three-hybrid system as a tool to study caspases.
Analytical biochemistry 1998;263(1):62-6.
1998: Penning L C; Schipper R G; Vercammen D; Verhofstad A A; Denecker T; Beyaert R; Vandenabeele P
Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.
Cytokine 1998;10(6):423-31.
1998: Vercammen D; Beyaert R; Denecker G; Goossens V; Van Loo G; Declercq W; Grooten J; Fiers W; Vandenabeele P
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.
The Journal of experimental medicine 1998;187(9):1477-85.
1998: Carpentier I; Declercq W; Malinin N L; Wallach D; Fiers W; Beyaert R
TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways.
FEBS letters 1998;425(2):195-8.
1997: Vercammen D; Vandenabeele P; Beyaert R; Declercq W; Fiers W
Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.
Cytokine 1997;9(11):801-8.
1997: Decoster E; Vandevoorde V; Beyaert R; Haegeman G; Fiers W
Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.
FEBS letters 1997;416(2):183-6.
1997: Denecker G; Vandenabeele P; Grooten J; Penning L C; Declercq W; Beyaert R; Buurman W A; Fiers W
Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.
Cytokine 1997;9(9):631-8.
1997: De Valck D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R
A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.
Biochemical and biophysical research communications 1997;238(2):590-4.
1997: Wallach D; Boldin M; Varfolomeev E; Beyaert R; Vandenabeele P; Fiers W
Cell death induction by receptors of the TNF family: towards a molecular understanding.
FEBS letters 1997;410(1):96-106.
1997: Barge R M; Willemze R; Vandenabeele P; Fiers W; Beyaert R
Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal.
FEBS letters 1997;409(2):207-10.
1997: Van de Craen M; Van den Brande I; Declercq W; Irmler M; Beyaert R; Tschopp J; Fiers W; Vandenabeele P
Cleavage of caspase family members by granzyme B: a comparative study in vitro.
European journal of immunology 1997;27(5):1296-9.
1997: Beyaert R; Kidd V J; Cornelis S; Van de Craen M; Denecker G; Lahti J M; Gururajan R; Vandenabeele P; Fiers W
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.
The Journal of biological chemistry 1997;272(18):11694-7.
1997: Van de Craen M; Vandenabeele P; Declercq W; Van den Brande I; Van Loo G; Molemans F; Schotte P; Van Criekinge W; Beyaert R; Fiers W
Characterization of seven murine caspase family members.
FEBS letters 1997;403(1):61-9.
1996: Van Criekinge W; Beyaert R; Van de Craen M; Vandenabeele P; Schotte P; De Valck D; Fiers W
Functional characterization of the prodomain of interleukin-1beta-converting enzyme.
The Journal of biological chemistry 1996;271(44):27245-8.
1996: Niki T; Schuppan D; de Bleser P J; Vrijsen R; Pipeleers-Marichal M; Beyaert R; Wisse E; Geerts A
Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells.
Hepatology (Baltimore, Md.) 1996;23(6):1673-81.
1996: De Valck D; Heyninck K; Van Criekinge W; Contreras R; Beyaert R; Fiers W
A20, an inhibitor of cell death, self-associates by its zinc finger domain.
FEBS letters 1996;384(1):61-4.
1996: Beyaert R; Cuenda A; Vanden Berghe W; Plaisance S; Lee J C; Haegeman G; Cohen P; Fiers W
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.
The EMBO journal 1996;15(8):1914-23.
1995: Vandenabeele P; Declercq W; Beyaert R; Fiers W
Two tumour necrosis factor receptors: structure and function.
Trends in cell biology 1995;5(10):392-9.
1995: Beyaert R; Vanhaesebroeck B; Declercq W; Van Lint J; Vandenabele P; Agostinis P; Vandenheede J R; Fiers W
Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis.
The Journal of biological chemistry 1995;270(40):23293-9.
1995: Fiers W; Beyaert R; Boone E; Cornelis S; Declercq W; Decoster E; Denecker G; Depuydt B; De Valck D; De Wilde G; Goossens V; Grooten J; Haegeman G; Heyninck K; Penning L; Plaisance S; Vancompernolle K; Van Criekinge W; Vandenabeele P; Vanden Berghe W; Van de Craen M; Vandevoorde V; Vercammen D
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Journal of inflammation 1995;47(1-2):67-75.
1994: Vandenabeele P; Goossens V; Beyaert R; Declercq W; Grooten J; Vanhaesebroeck B; Van de Craen M; Vercammen D; Depuydt B; Denecker G
Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity.
Circulatory shock 1994;44(4):196-200.
1994: Beyaert R; Fiers W
Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not.
FEBS letters 1994;340(1-2):9-16.
1993: Schulze-Osthoff K; Beyaert R; Vandevoorde V; Haegeman G; Fiers W
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
The EMBO journal 1993;12(8):3095-104.
1993: Beyaert R; Heyninck K; De Valck D; Boeykens F; van Roy F; Fiers W
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):291-300.
1993: Beyaert R; Vanhaesebroeck B; Heyninck K; Boone E; De Valck D; Schulze-Osthoff K; Haegeman G; Van Roy F; Fiers W
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
Cancer research 1993;53(11):2623-30.
1993: Vanhaesebroeck B; Reed J C; De Valck D; Grooten J; Miyashita T; Tanaka S; Beyaert R; Van Roy F; Fiers W
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.
Oncogene 1993;8(4):1075-81.
1993: De Valck D; Beyaert R; Van Roy F; Fiers W
Tumor necrosis factor cytotoxicity is associated with phospholipase D activation.
European journal of biochemistry / FEBS 1993;212(2):491-7.
1992: Beyaert R; Schulze-Osthoff K; Van Roy F; Fiers W
Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: possible role in the triggering and exacerbation of psoriasis by lithium treatment.
European journal of immunology 1992;22(8):2181-4.
1992: Schulze-Osthoff K; Bakker A C; Vanhaesebroeck B; Beyaert R; Jacob W A; Fiers W
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
The Journal of biological chemistry 1992;267(8):5317-23.
1991: Beyaert R; Schulze-Osthoff K; Van Roy F; Fiers W
Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression.
Cytokine 1991;3(4):284-91.
1991: Vanhaesebroeck B; Van Bladel S; Lenaerts A; Suffys P; Beyaert R; Lucas R; Van Roy F; Fiers W
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.
Cancer research 1991;51(9):2469-77.
1991: Beyaert R; De Potter C; Vanhaesebroeck B; Van Roy F; Fiers W
Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride.
The American journal of pathology 1991;138(3):727-39.
1991: Suffys P; Beyaert R; De Valck D; Vanhaesebroeck B; Van Roy F; Fiers W
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.
European journal of biochemistry / FEBS 1991;195(2):465-75.
1990: Van Roy F; Mareel M; Vleminckx K; Beyaert R; Fiers W; Devleeschouwer N; Muquardt C; Legros N; Bracke M; Leclercq G
Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives.
International journal of cancer. Journal international du cancer 1990;46(3):522-32.
1990: Beyaert R; Suffys P; Van Roy F; Fiers W
Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement.
FEBS letters 1990;262(1):93-6.
1990: Vanhaesebroeck B; Cragoe E J; Pouysségur J; Beyaert R; Van Roy F; Fiers W
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter.
FEBS letters 1990;261(2):319-22.
1990: Fiers W; Beyaert R; Brouckaert P; Everaerdt B; Grooten J; Lenaerts A; Libert C; Suffys P; Takahashi N; Tavernier J
Tumour necrosis factor: mechanism of action at the molecular, cellular and in vivo level.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1990;202():159.
1989: Beyaert R; Vanhaesebroeck B; Suffys P; Van Roy F; Fiers W
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9494-8.
1989: Suffys P; Beyaert R; Van Roy F; Fiers W
TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells.
Anticancer research 1989;9(1):167-71.
1988: Suffys P; Beyaert R; Van Roy F; Fiers W
Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity.
European journal of biochemistry / FEBS 1988;178(1):257-65.
1988: Fiers W; Beyaert R; Brouckaert P; Everaerdt B; Haegeman C; Suffys P; Tavernier J; Vanhaesebroeck B
TNF: its potential as an antitumour agent.
Developments in biological standardization 1988;69():143-51.
1987: Fiers W; Beyaert R; Brouckaert P; Everaerdt B; Haegeman G; Suffys P; Tavernier J; Vandenabeele P; Vanhaesebroeck B; Van Ostade X
Gene cloning and structure--function relationship of cytokines such as TNF and interleukins.
Immunology letters 1987;16(3-4):219-26.
1987: Suffys P; Beyaert R; Van Roy F; Fiers W
Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism.
Biochemical and biophysical research communications 1987;149(2):735-43.
1987: Fiers W; Beyaert R; Brouckaert P; Everaert B; Suffys P; Tavernier J; Van Haesebroeck B; Van Roy F
Tumor necrosis factor: a potential antitumor agent?
Journal of interferon research 1987;7(5):627-34.

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