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Toshihiro Akihisa

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Toshihiro Akihisa; Makoto Fukatsu; Takashi Kikuchi; Kazuo Koike; Masahiro Matsumoto; Yasuhiro Nakamura; Eri Ogihara; Xin Pan; Nami Takahashi; Harukuni Tokuda
Limonoids from the fruits of Melia azedarach and their cytotoxic activities.
Toshihiro Akihisa; Hiroyuki Akazawa; Makoto Fukatsu; Kohta Kawashima; Masahiro Matsumoto; Eri Ogihara; Masashi Orido; Harukuni Tokuda; Ayako Yamamoto; Jizaemon Fuji
Antioxidative and melanogenesis-inhibitory activities of caffeoylquinic acids and other compounds from moxa.
Motohiko Ukiya; Makoto Fukatsu; Takashi Kikuchi; Yasunori Kushi; Shingo Sawada; Toshihiro Akihisa
Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines.

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2013: Toshihiro Akihisa; Makoto Fukatsu; Takashi Kikuchi; Kazuo Koike; Masahiro Matsumoto; Yasuhiro Nakamura; Eri Ogihara; Xin Pan; Nami Takahashi; Harukuni Tokuda
Limonoids from the fruits of Melia azedarach and their cytotoxic activities.
Phytochemistry 2013;89():59-70.
2013: Toshihiro Akihisa; Hiroyuki Akazawa; Makoto Fukatsu; Kohta Kawashima; Masahiro Matsumoto; Eri Ogihara; Masashi Orido; Harukuni Tokuda; Ayako Yamamoto; Jizaemon Fuji
Antioxidative and melanogenesis-inhibitory activities of caffeoylquinic acids and other compounds from moxa.
Chemistry & biodiversity 2013;10(3):313-27.
2013: Motohiko Ukiya; Makoto Fukatsu; Takashi Kikuchi; Yasunori Kushi; Shingo Sawada; Toshihiro Akihisa
Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines.
Chemistry & biodiversity 2013;10(2):177-88.
2013: Toshihiro Akihisa; Hiroyuki Akazawa; Eri Ogihara; Masashi Orido; Akitomo Takahashi; Ayako Yamamoto; Makoto Fukatsu
Melanogenesis-inhibitory activity of aromatic glycosides from the stem bark of Acer buergerianum.
Chemistry & biodiversity 2013;10(2):167-76.
2013: Takashi Kikuchi; Kazuo Koike; Yasuhiro Nakamura; Eri Ogihara; Xin Pan; Reiko Tanaka; Koichi Ishii; Toshihiro Akihisa
Cytotoxic and apoptosis-inducing activities of 12-O-Acetylazedarachin B from the fruits of Melia azedarach in human cancer cell lines.
Biological & pharmaceutical bulletin 2013;36(1):135-9.
2012: Keiichi Tabata; Toshihiro Akihisa; Aoi Hamano; Takashi Suzuki
Kuguaglycoside C, a constituent of Momordica charantia, induces caspase-independent cell death of neuroblastoma cells.
Cancer science 2012;103(12):2153-8.
2012: Takashi Kikuchi; Reiko Tanaka; Yuichi Tochigi; Kensuke Watanabe; Ayako Yamamoto; Yoichiro Ezaki; Makoto Fukatsu; Toshihiro Akihisa
Melanogenesis inhibitory activity of sesquiterpenes from Canarium ovatum resin in mouse B16 melanoma cells.
Chemistry & biodiversity 2012;9(8):1500-7.
2012: Toshihiro Akihisa; Masahiro Matsumoto; Kensuke Watanabe; Ayako Yamamoto; Jie Zhang; Makoto Fukatsu
Melanogenesis inhibitory activity of monoterpene glycosides from Gardeniae Fructus.
Chemistry & biodiversity 2012;9(8):1490-9.
2012: Toshihiro Akihisa; Makoto Fukatsu; Takashi Kikuchi; Ayano Takeda; Motohiko Ukiya; Hiroyuki Akazawa; Satoru Yokokawa; Kensuke Watanabe
Melanogenesis-inhibitory and cytotoxic activities of diarylheptanoids from Acer nikoense bark and their derivatives.
Chemistry & biodiversity 2012;9(8):1475-89.
2012: Takashi Kikuchi; Reiko Tanaka; Kensuke Watanabe; Ayako Yamamoto; Jie Zhang; Makoto Fukatsu; Yan Huang; Kenta Ishii; Toshihiro Akihisa
Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia.
Chemistry & biodiversity 2012;9(7):1221-30.
2012: Toshihiro Akihisa; Makoto Fukatsu; Takashi Kikuchi; Nami Takahashi; Shun Tochizawa; Harukuni Tokuda; Ayako Yamamoto; Jie Zhang; Nobutaka Suzuki
Melanogenesis-inhibitory saccharide fatty acid esters and other constituents of the fruits of Morinda citrifolia (noni).
Chemistry & biodiversity 2012;9(6):1172-87.
2012: Hiroyuki Akazawa; Yumiko Kimura; Hideki Kohno; Aranya Manosroi; Jiradej Manosroi; Nobutaka Suzuki; Harukuni Tokuda; Ken Yasukawa; Toshihiro Akihisa
Anti-inflammatory and anti-tumor-promoting effects of 5-deprenyllupulonol C and other compounds from Hop (Humulus lupulus L.).
Chemistry & biodiversity 2012;9(6):1045-54.
2012: Jie Zhang; Yan Huang; Kei-ichiro Inafuku; Takashi Kikuchi; Motofumi Miura; Shigeyasu Motohashi; Nobutaka Suzuki; Takashi Suzuki; Harukuni Tokuda; Toshihiro Akihisa
Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities.
Chemistry & biodiversity 2012;9(2):428-40.
2012: Toshihiro Akihisa; Makoto Fukatsu; Takashi Kikuchi; Toshihiro Motoi; Akihito Seki; Nobutaka Suzuki; Harukuni Tokuda; Yumiko Kimura
Cytotoxic activities and anti-tumor-promoting effects of microbial transformation products of prenylated chalcones from Angelica keiskei.
Chemistry & biodiversity 2012;9(2):318-30.
2011: Aranya Manosroi; Toshihiro Akihisa; Pensak Jantrawut; Worapaka Manosroi; Jiradej Manosroi
In vitro and in vivo skin anti-aging evaluation of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from Terminalia chebula galls.
Pharmaceutical biology 2011;49(11):1190-203.
2011: Takayuki Yonezawa; Ji-Won Lee; Hiroyuki Akazawa; Masahiko Inagaki; Byung-Yoon Cha; Kazuo Nagai; Kazumi Yagasaki; Toshihiro Akihisa; Je-Tae Woo
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
Bioorganic & medicinal chemistry letters 2011;21(11):3248-51.
2011: Aranya Manosroi; Pensak Jantrawut; Hiroyuki Akazawa; Toshihiro Akihisa; Worapaka Manosroi; Jiradej Manosroi
Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls.
Pharmaceutical biology 2011;49(6):553-62.
2011: Takashi Kikuchi; Koichi Ishii; Taisuke Noto; Akitomo Takahashi; Keiichi Tabata; Takashi Suzuki; Toshihiro Akihisa
Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).
Journal of natural products 2011;74(4):866-70.
2011: Tasuku Kihara; Saki Ichikawa; Takayuki Yonezawa; Ji-Won Lee; Toshihiro Akihisa; Je-Tae Woo; Yasuyuki Michi; Teruo Amagasa; Akira Yamaguchi
Acerogenin A, a natural compound isolated from Acer nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action.
Biochemical and biophysical research communications 2011;406(2):211-7.
2011: Takashi Kikuchi; Emiko Uchiyama; Motohiko Ukiya; Keiichi Tabata; Yumiko Kimura; Takashi Suzuki; Toshihiro Akihisa
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
Journal of natural products 2011;74(2):137-44.
2011: Toshihiro Akihisa; Makoto Fukatsu; Naoko Katoh; Takashi Kikuchi; Nobuo Kojima; Naoto Shimizu; Eliot T Masters
Triacylglycerol and triterpene ester composition of shea nuts from seven African countries.
Journal of oleo science 2011;60(8):385-91.
2011: Takashi Kikuchi; Hiroyuki Akazawa; Keiichi Tabata; Aranya Manosroi; Jiradej Manosroi; Takashi Suzuki; Toshihiro Akihisa
3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line.
Chemical & pharmaceutical bulletin 2011;59(3):378-81.
2011: Toshihiro Akihisa; Takashi Kikuchi; Hisashi Nagai; Koichi Ishii; Keiichi Tabata; Takashi Suzuki
4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.
Journal of oleo science 2011;60(2):71-7.
2011: Toshihiro Akihisa; Akitomo Takahashi; Takashi Kikuchi; Mio Takagi; Kensuke Watanabe; Makoto Fukatsu; Yukiko Fujita; Norihiro Banno; Harukuni Tokuda; Ken Yasukawa
The melanogenesis-inhibitory, anti-inflammatory, and chemopreventive effects of limonoids in n-hexane extract of Azadirachta indica A. Juss. (neem) seeds.
Journal of oleo science 2011;60(2):53-9.
2010: Aranya Manosroi; Pensak Jantrawut; Hiroyuki Akazawa; Toshihiro Akihisa; Jiradej Manosroi
Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae).
Natural product research 2010;24(20):1915-26.
2010: Motohiko Ukiya; Takashi Kikuchi; Harukuni Tokuda; Keiichi Tabata; Yumiko Kimura; Takanari Arai; Yoichiro Ezaki; Osamu Oseto; Takashi Suzuki; Toshihiro Akihisa
Antitumor-promoting effects and cytotoxic activities of dammar resin triterpenoids and their derivatives.
Chemistry & biodiversity 2010;7(8):1871-84.
2010: Jiradej Manosroi; Kanjana Rueanto; Korawinwich Boonpisuttinant; Worapaka Manosroi; Christophe Biot; Hiroyuki Akazawa; Toshihiro Akihisa; Witchapong Issarangporn; Aranya Manosroi
Novel ferrocenic steroidal drug derivatives and their bioactivities.
Journal of medicinal chemistry 2010;53(10):3937-43.
2010: Aranya Manosroi; Pensak Jantrawut; Toshihiro Akihisa; Worapaka Manosroi; Jiradej Manosroi
In vitro anti-aging activities of Terminalia chebula gall extract.
Pharmaceutical biology 2010;48(4):469-81.
2010: Shoujiro Ogawa; Yasuo Wakatsuki; Mitsuko Makino; Yasuo Fujimoto; Ken Yasukawa; Takashi Kikuchi; Motohiko Ukiya; Toshihiro Akihisa; Takashi Iida
Oxyfunctionalization of unactivated C-H bonds in triterpenoids with tert-butylhydroperoxide catalyzed by meso-5,10,15,20-tetramesitylporphyrinate osmium(II) carbonyl complex.
Chemistry and physics of lipids 2010;163(2):165-71.
2010: Toshihiro Akihisa; Nobuo Kojima; Naoko Katoh; Yuki Ichimura; Hirohisa Suzuki; Makoto Fukatsu; Steven Maranz; Eliot T Masters
Triterpene alcohol and fatty acid composition of shea nuts from seven African countries.
Journal of oleo science 2010;59(7):351-60.
2010: Toshihiro Akihisa; Nobuo Kojima; Takashi Kikuchi; Ken Yasukawa; Harukuni Tokuda; Eliot T Masters; Aranya Manosroi; Jiradej Manosroi
Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat.
Journal of oleo science 2010;59(6):273-80.
2010: Hiroyuki Akazawa; Yukiko Fujita; Norihiro Banno; Kensuke Watanabe; Yumiko Kimura; Aranya Manosroi; Jiradej Manosroi; Toshihiro Akihisa
Three new cyclic diarylheptanoids and other phenolic compounds from the bark of Myrica rubra and their melanogenesis inhibitory and radical scavenging activities.
Journal of oleo science 2010;59(4):213-21.
2010: Toshihiro Akihisa; Ken-ichi Seino; Etsuyo Kaneko; Kensuke Watanabe; Shun Tochizawa; Makoto Fukatsu; Norihiro Banno; Koichi Metori; Yumiko Kimura
Melanogenesis inhibitory activities of iridoid-, hemiterpene-, and fatty acid-glycosides from the fruits of Morinda citrifolia (Noni).
Journal of oleo science 2010;59(1):49-57.
2009: Toshihiro Akihisa; Emiko Uchiyama; Takashi Kikuchi; Harukuni Tokuda; Takashi Suzuki; Yumiko Kimura
Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos.
Journal of natural products 2009;72(10):1786-92.
2009: Toshihiro Akihisa; Taisuke Noto; Akitomo Takahashi; Yukiko Fujita; Norihiro Banno; Harukuni Tokuda; Kazuo Koike; Takashi Suzuki; Ken Yasukawa; Yumiko Kimura
Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indicia A. Juss. (neem).
Journal of oleo science 2009;58(11):581-94.
2008: Kou Motani; Keiichi Tabata; Yumiko Kimura; Soichiro Okano; Yasuko Shibata; Yoshimitsu Abiko; Hisashi Nagai; Toshihiro Akihisa; Takashi Suzuki
Proteomic analysis of apoptosis induced by xanthoangelol, a major constituent of Angelica keiskei, in neuroblastoma.
Biological & pharmaceutical bulletin 2008;31(4):618-26.
2008: Sachiko Kishiro; Satoshi Nunomura; Hisashi Nagai; Toshihiro Akihisa; Chisei Ra
Selinidin suppresses IgE-mediated mast cell activation by inhibiting multiple steps of Fc epsilonRI signaling.
Biological & pharmaceutical bulletin 2008;31(3):442-8.
2007: Reiko Nishimura; Keiichi Tabata; Motoki Arakawa; Yoshihisa Ito; Yumiko Kimura; Toshihiro Akihisa; Hisashi Nagai; Atsuko Sakuma; Hideki Kohno; Takashi Suzuki
Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.
Biological & pharmaceutical bulletin 2007;30(10):1878-83.
2007: Toshihiro Akihisa; Naoki Higo; Harukuni Tokuda; Motohiko Ukiya; Hiroyuki Akazawa; Yuichi Tochigi; Yumiko Kimura; Takashi Suzuki; Hoyoku Nishino
Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects.
Journal of natural products 2007;70(8):1233-9.
2007: Takashi Kikuchi; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Kenji Watanabe; Hoyoku Nishino
Cancer chemopreventive effects of cycloartane-type and related triterpenoids in in vitro and in vivo models.
Journal of natural products 2007;70(6):918-22.
2007: Toshihiro Akihisa; Yuji Nakamura; Harukuni Tokuda; Emiko Uchiyama; Takashi Suzuki; Yumiko Kimura; Kazuo Uchikura; Hoyoku Nishino
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
Journal of natural products 2007;70(6):948-53.
2007: Motohiko Ukiya; Toshihiro Akihisa; Ken Yasukawa; Kazuo Koike; Akitomo Takahashi; Takashi Suzuki; Yumiko Kimura
Triterpene glycosides from the flower petals of sunflower (Helianthus annuus) and their anti-inflammatory activity.
Journal of natural products 2007;70(5):813-6.
2007: Toshihiro Akihisa; Kazumi Matsumoto; Harukuni Tokuda; Ken Yasukawa; Ken-ichi Seino; Katsuo Nakamoto; Hideki Kuninaga; Takashi Suzuki; Yumiko Kimura
Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni).
Journal of natural products 2007;70(5):754-7.
2007: Toshihiro Akihisa; Yosuke Hayakawa; Harukuni Tokuda; Norihiro Banno; Naoto Shimizu; Takashi Suzuki; Yumiko Kimura
Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2007;70(5):783-8.
2007: Toshihiro Akihisa; Yuji Nakamura; Masaaki Tagata; Harukuni Tokuda; Ken Yasukawa; Emiko Uchiyama; Takashi Suzuki; Yumiko Kimura
Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum.
Chemistry & biodiversity 2007;4(2):224-31.
2006: Motohiko Ukiya; Toshihiro Akihisa; Ken Yasukawa; Harukuni Tokuda; Takashi Suzuki; Yumiko Kimura
Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers.
Journal of natural products 2006;69(12):1692-6.
2006: Norihiro Banno; Toshihiro Akihisa; Ken Yasukawa; Harukuni Tokuda; Keiichi Tabata; Yuji Nakamura; Reiko Nishimura; Yumiko Kimura; Takashi Suzuki
Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri.
Journal of ethnopharmacology 2006;107(2):249-53.
2006: Toshihiro Akihisa; Keiichi Tabata; Norihiro Banno; Harukuni Tokuda; Reiko Nishimura; Reiko Nishihara; Yuji Nakamura; Yumiko Kimura; Ken Yasukawa; Takashi Suzuki
Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri.
Biological & pharmaceutical bulletin 2006;29(9):1976-9.
2006: Hiroyuki Akazawa; Toshihiro Akihisa; Yosuke Taguchi; Norihiro Banno; Risa Yoneima; Ken Yasukawa
Melanogenesis inhibitory and free radical scavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense.
Biological & pharmaceutical bulletin 2006;29(9):1970-2.
2006: Toshihiro Akihisa; Yosuke Taguchi; Ken Yasukawa; Harukuni Tokuda; Hiroyuki Akazawa; Takashi Suzuki; Yumiko Kimura
Acerogenin M, a cyclic diarylheptanoid, and other phenolic compounds from Acer nikoense and their anti-inflammatory and anti-tumor-promoting effects.
Chemical & pharmaceutical bulletin 2006;54(5):735-9.
2006: Toshihiro Akihisa; Kenji Watanabe; Risa Yoneima; Takashi Suzuki; Yumiko Kimura
Biotransformation of cycloartane-type triterpenes by the fungus Glomerella fusarioides.
Journal of natural products 2006;69(4):604-7.
2006: Toshihiro Akihisa; Harukuni Tokuda; Daisuke Hasegawa; Motohiko Ukiya; Yumiko Kimura; Fumio Enjo; Takashi Suzuki; Hoyoku Nishino
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
Journal of natural products 2006;69(1):38-42.
2005: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Ayaka Kiyota; Ken Yasukawa; Naoyuki Sakamoto; Yumiko Kimura; Takashi Suzuki; Junko Takayasu; Hoyoku Nishino
Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice).
Chemistry & biodiversity 2005;2(10):1305-9.
2005: Norihiro Banno; Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Yosuke Taguchi; Hiroyuki Akazawa; Motohiko Ukiya; Yumiko Kimura; Takashi Suzuki; Hoyoku Nishino
Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica.
Biological & pharmaceutical bulletin 2005;28(10):1995-9.
2005: Yoshiyuki Mizushina; Toshihiro Akihisa; Motohiko Ukiya; Yusuke Hamasaki; Chikako Murakami-Nakai; Isoko Kuriyama; Toshifumi Takeuchi; Fumio Sugawara; Hiromi Yoshida
Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors.
Life sciences 2005;77(17):2127-40.
2005: Keiichi Tabata; Kou Motani; Noriya Takayanagi; Reiko Nishimura; Satoru Asami; Yumiko Kimura; Motohiko Ukiya; Daisuke Hasegawa; Toshihiro Akihisa; Takashi Suzuki
Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells.
Biological & pharmaceutical bulletin 2005;28(8):1404-7.
2005: Toshihiro Akihisa; Scott Franzblau; Harukuni Tokuda; Masaaki Tagata; Motohiko Ukiya; Tsunetomo Matsuzawa; Koichi Metori; Yumiko Kimura; Takashi Suzuki; Ken Yasukawa
Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizigus marmoreus.
Biological & pharmaceutical bulletin 2005;28(6):1117-9.
2005: Yumiko Kimura; Toshihiro Akihisa; Noriko Yuasa; Motohiko Ukiya; Takashi Suzuki; Masaharu Toriyama; Shigeyasu Motohashi; Harukuni Tokuda
Cucurbitane-type triterpenoids from the fruit of Momordica charantia.
Journal of natural products 2005;68(5):807-9.
2005: Toshihiro Akihisa; Masaaki Tagata; Motohiko Ukiya; Harukuni Tokuda; Takashi Suzuki; Yumiko Kimura
Oxygenated lanostane-type triterpenoids from the fungus ganodermalucidum.
Journal of natural products 2005;68(4):559-63.
2005: Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Motohiko Ukiya; Ayaka Kiyota; Naoyuki Sakamoto; Takashi Suzuki; Nobukazu Tanabe; Hoyoku Nishino
Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects.
Journal of agricultural and food chemistry 2005;53(3):562-5.
2005: Toshihiro Akihisa; Scott Franzblau; Motohiko Ukiya; Hiroki Okuda; Fangqiu Zhang; Ken Yasukawa; Takashi Suzuki; Yumiko Kimura
Antitubercular activity of triterpenoids from Asteraceae flowers.
Biological & pharmaceutical bulletin 2005;28(1):158-60.
2004: Yoshiyuki Mizushina; Toshihiro Akihisa; Motohiko Ukiya; Chikako Murakami; Isoko Kuriyama; Xianai Xu; Hiromi Yoshida; Kengo Sakaguchi
A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos.
Cancer science 2004;95(4):354-60.
2004: Toshihiro Akihisa; Harukuni Tokuda; Masakazu Ogata; Motohiko Ukiya; Masao Iizuka; Takashi Suzuki; Koichi Metori; Naoto Shimizu; Hoyoku Nishino
Cancer chemopreventive effects of polyunsaturated fatty acids.
Cancer letters 2004;205(1):9-13.
2004: Toshihiro Akihisa; Shoichi Mafune; Motohiko Ukiya; Yumiko Kimura; Ken Yasukawa; Takashi Suzuki; Harukuni Tokuda; Nobukazu Tanabe; Tadahiko Fukuoka
(+)- and (-)-syn-2-isobutyl-4-methylazetidine-2,4-dicarboxylic acids from the extract of Monascus pilosus-fermented rice (red-mold rice).
Journal of natural products 2004;67(3):479-80.
2004: Toshihiro Akihisa; Yusuke Hamasaki; Harukuni Tokuda; Motohiko Ukiya; Yumiko Kimura; Hoyoku Nishino
Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products.
Journal of natural products 2004;67(3):407-10.
2004: Toshihiro Akihisa; Yoshiyuki Mizushina; Motohiko Ukiya; Manabu Oshikubo; Seizo Kondo; Yumiko Kimura; Takashi Suzuki; Takaaki Tai
Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase alpha and beta.
Bioscience, biotechnology, and biochemistry 2004;68(2):448-50.
2004: Norihiro Banno; Toshihiro Akihisa; Harukuni Tokuda; Ken Yasukawa; Hiroshi Higashihara; Motohiko Ukiya; Kenji Watanabe; Yumiko Kimura; Jun-Ichi Hasegawa; Hoyoku Nishino
Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.
Bioscience, biotechnology, and biochemistry 2004;68(1):85-90.
2004: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Toshie Suzuki; Fumio Enjo; Kazuo Koike; Tamotsu Nikaido; Hoyoku Nishino
3-epicabraleahydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr virus activation.
Chemical & pharmaceutical bulletin 2004;52(1):153-6.
2003: Kenji Iwatsuki; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Manabu Oshikubo; Yumiko Kimura; Takeshi Asano; Atsushi Nomura; Hoyoku Nishino
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2003;66(12):1582-5.
2003: Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Masao Iizuka; Stefan Schneider; Kazuya Ogasawara; Teruo Mukainaka; Kenji Iwatsuki; Takashi Suzuki; Hoyoku Nishino
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects.
Cancer letters 2003;201(2):133-7.
2003: Kenji Iwatsuki; Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Hiroshi Higashihara; Teruo Mukainaka; Masao Iizuka; Yoshiharu Hayashi; Yumiko Kimura; Hoyoku Nishino
Sterol ferulates, sterols, and 5-alk(en)ylresorcinols from wheat, rye, and corn bran oils and their inhibitory effects on Epstein-Barr virus activation.
Journal of agricultural and food chemistry 2003;51(23):6683-8.
2003: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Kazuo Koike; Yumiko Kimura; Takeshi Asano; Shigeyasu Motohashi; Tamotsu Nikaido; Hoyoku Nishino
Sunpollenol and five other rearranged 3,4-seco-tirucallane-type triterpenoids from sunflower pollen and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2003;66(11):1476-9.
2003: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Kazuo Koike; Junko Takayasu; Hiroki Okuda; Yumiko Kimura; Tamotsu Nikaido; Hoyoku Nishino
Isolation, structural elucidation, and inhibitory effects of terpenoid and lipid constituents from sunflower pollen on Epstein-Barr virus early antigen induced by tumor promoter, TPA.
Journal of agricultural and food chemistry 2003;51(10):2949-57.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Masakazu Toriumi; Teruo Mukainaka; Norihiro Banno; Yumiko Kimura; Jun-Ichi Hasegawa; Hoyoku Nishino
Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Journal of agricultural and food chemistry 2002;50(23):6710-5.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Masaya Hirano; Manabu Oshikubo; Yoshitoshi Nobukuni; Yumiko Kimura; Takaaki Tai; Seizo Kondo; Hoyoku Nishino
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
Journal of natural products 2002;65(4):462-5.
2002: Motohiko Ukiya; Toshihiro Akihisa; Harukuni Tokuda; Hiroyuki Suzuki; Teruo Mukainaka; Eiichiro Ichiishi; Ken Yasukawa; Yoshimasa Kasahara; Hoyoku Nishino
Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.
Cancer letters 2002;177(1):7-12.
2002: Toshihiro Akihisa; Yoshio Takamine; Kazuo Yoshizumi; Harukuni Tokuda; Yumiko Kimura; Motohiko Ukiya; Toro Nakahara; Toshihiro Yokochi; Eiichiro Ichiishi; Hoyoku Nishino
Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation products.
Journal of natural products 2002;65(3):278-82.
2002: Motohiko Ukiya; Toshihiro Akihisa; Ken Yasukawa; Harukuni Tokuda; Masakazu Toriumi; Kazuo Koike; Yumiko Kimura; Tamotsu Nikaido; Wataru Aoi; Hoyoku Nishino; Michio Takido
Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica.
Journal of natural products 2002;65(2):179-83.
2002: Toshihiro Akihisa; E M Kithsiri Wijeratne; Harukuni Tokuda; Fumio Enjo; Masakazu Toriumi; Yumiko Kimura; Kazuo Koike; Tamotsu Nikaido; Yasuhiro Tezuka; Hoyoku Nishino
Eupha-7,9(11),24-trien-3beta-ol ("antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation.
Journal of natural products 2002;65(2):158-62.
2001: Toshihiro Akihisa; Harukuni Tokuda; Eiichiro Ichiishi; Teruo Mukainaka; Masakazu Toriumi; Motohiko Ukiya; Ken Yasukawa; Hoyoku Nishino
Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines.
Cancer letters 2001;173(1):9-14.
2001: A Rajic; Toshihiro Akihisa; Motohiko Ukiya; K Yasukawa; R Mark Sandeman; David S Chandler; GM Polya
Inhibition of trypsin and chymotrypsin by anti-inflammatory triterpenoids from Compositae flowers.
Planta medica 2001;67(7):599-604.
2001: Motohiko Ukiya; Toshihiro Akihisa; Ken Yasukawa; Yoshimasa Kasahara; Yumiko Kimura; Kazuo Koike; Tamotsu Nikaido; Michio Takido
Constituents of compositae plants. 2. Triterpene diols, triols, and their 3-o-fatty acid esters from edible chrysanthemum flower extract and their anti-inflammatory effects.
Journal of agricultural and food chemistry 2001;49(7):3187-97.
2001: Toshihiro Akihisa; Jun Ogihara; Jun Kato; Ken Yasukawa; Motohiko Ukiya; S Yamanouchi; K Oishi
Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase.
Lipids 2001;36(5):507-12.
2000: Motohiko Ukiya; Toshihiro Akihisa; Shigeyasu Motohashi; Ken Yasukawa; Yumiko Kimura; Yoshimasa Kasahara; Michio Takido; N Tokutake
6S,8R-Stereochemistry of the C27- and C29-alkane-6,8-diols isolated from three compositae flowers.
Chemical & pharmaceutical bulletin 2000;48(8):1187-9.
2000: Toshihiro Akihisa; Ken Yasukawa; M Yamaura; Motohiko Ukiya; Yumiko Kimura; N Shimizu; K Arai
Triterpene alcohol and sterol ferulates from rice bran and their anti-inflammatory effects.
Journal of agricultural and food chemistry 2000;48(6):2313-9.
2000: Ken Yasukawa; Toshihiro Akihisa; Z Y Yoshida; Michio Takido
Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
The Journal of pharmacy and pharmacology 2000;52(1):119-24.
1999: Toshihiro Akihisa; Kazuo Koike; Yumiko Kimura; N Sashida; T Matsumoto; Motohiko Ukiya; Tamotsu Nikaido
Acyclic and incompletely cyclized triterpene alcohols in the seed oils of theaceae and gramineae.
Lipids 1999;34(11):1151-7.
1998: Ken Yasukawa; Toshihiro Akihisa; Yumiko Kimura; T Tamura; Michio Takido
Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin.
Biological & pharmaceutical bulletin 1998;21(10):1072-6.
1998: Ken Yasukawa; T Tamura; Motohiko Ukiya; S Yamanouchi; Toshihiro Akihisa; Y Kasahara; K Kumaki; Michio Takido
Inhibitory effect of heliantriol C; a component of edible Chrysanthemum, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1998;5(3):215-8.
1998: Toshihiro Akihisa; Ken Yasukawa; Yumiko Kimura; S Yamanouchi; T Tamura
Sasanquol, a 3,4-seco-triterpene alcohol from sasanqua oil, and its anti-inflammatory effect.
Phytochemistry 1998;48(2):301-5.
1997: Toshihiro Akihisa; Ken Yasukawa; Yumiko Kimura; S Takase; S Yamanouchi; T Tamura
Triterpene alcohols from camellia and sasanqua oils and their anti-inflammatory effects.
Chemical & pharmaceutical bulletin 1997;45(12):2016-23.
1996: Toshihiro Akihisa; Ken Yasukawa; H Oinuma; Y Kasahara; S Yamanouchi; Michio Takido; K Kumaki; T Tamura
Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects.
Phytochemistry 1996;43(6):1255-60.
1996: Ken Yasukawa; Toshihiro Akihisa; H Oinuma; Y Kasahara; Yumiko Kimura; S Yamanouchi; K Kumaki; T Tamura; Michio Takido
Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.
Biological & pharmaceutical bulletin 1996;19(10):1329-31.
1996: Ken Yasukawa; Toshihiro Akihisa; H Oinuma; T Kaminaga; H Kanno; Y Kasahara; T Tamura; K Kumaki; S Yamanouchi; Michio Takido
Inhibitory effect of taraxastane-type triterpenes on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Oncology 1996;53(4):341-4.
1996: Ken Yasukawa; Toshihiro Akihisa; H Kanno; T Kaminaga; M Izumida; T Sakoh; T Tamura; Michio Takido
Inhibitory effects of sterols isolated from Chlorella vulgaris on 12-0-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin.
Biological & pharmaceutical bulletin 1996;19(4):573-6.
1996: Ken Yasukawa; Toshihiro Akihisa; Y Kasahara; T Kaminaga; H Kanno; K Kumaki; T Tamura; Michio Takido
Inhibitory effect of alkane-6,8-diols, the components of safflower, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Oncology 1996;53(2):133-6.
1995: Yumiko Kimura; Ken Yasukawa; Michio Takido; Toshihiro Akihisa; T Tamura
Inhibitory effect of some oxygenated stigmastane-type sterols on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.
Biological & pharmaceutical bulletin 1995;18(11):1617-9.
1995: S Motohashi; Toshihiro Akihisa; T Tamura; N Tokutake; Michio Takido; Ken Yasukawa
Alkane-6,8-diol: inhibitor of tumor promotion in two-stage carcinogenesis in mouse skin.
Journal of medicinal chemistry 1995;38(21):4155-6.
1995: Ken Yasukawa; S Yu; Toshihiro Akihisa; Michio Takido; S Yamanouchi; T Tamura
Some lupane-type triterpenes inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1995;1(4):309-13.
1994: Toshihiro Akihisa; Ken Yasukawa; Yumiko Kimura; Michio Takido; W C Kokke; T Tamura
Five D:C-friedo-oleanane triterpenes from the seeds of Trichosanthes kirilowii Maxim. and their anti-inflammatory effects.
Chemical & pharmaceutical bulletin 1994;42(5):1101-5.
1994: Ken Yasukawa; Toshihiro Akihisa; T Tamura; Michio Takido
Inhibitory effect of karounidiol on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion.
Biological & pharmaceutical bulletin 1994;17(3):460-2.
1992: Toshihiro Akihisa; W C Kokke; T Tamura; T Nambara
7-Oxodihydrokarounidiol [7-oxo-D:C-friedo-olean-8-ene-3 alpha,29-diol], a novel triterpene from Trichosanthes kirilowii.
Chemical & pharmaceutical bulletin 1992;40(5):1199-202.
1989: Toshihiro Akihisa; Y Matsubara; P Ghosh; S Thakur; T Tamura; T Matsumoto
Sterols of some Clerodendrum species (Verbenaceae): occurrence of the 24 alpha- and 24 beta-epimers of 24-ethylsterols lacking a delta 25-bond.
Steroids 1989;53(3-5):625-38.