Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Alan Fairlamb

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
16
Hunter, William
13
Ariyanayagam, Mark
12
Tetaud, Emmanuel
11
Oza, Sandra
10
Wyllie, Susan
9
Douglas, Kenneth
9
Bond, Charles
8
Vickers, Tim
8
McKie, JH
6
Saravanamuthu, Ahilan
6
Garforth, J
5
Greig, Neil
5
Alphey, Magnus
5
Croft, Simon
5
Yin, H

Sign-in to see all Coauthors

Publications

TOP 3
Perez-Pineiro Rolando; Burgos Asdrubal; Jones Deuan C; Andrew Lena C; Rodriguez Hortensia; Suarez Margarita; Fairlamb Alan H; Wishart David S
Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.
Greig Neil; Wyllie Susan; Patterson Stephen; Fairlamb Alan H
A comparative study of methylglyoxal metabolism in trypanosomatids.
Oza Sandra L; Chen Shoujun; Wyllie Susan; Coward James K; Fairlamb Alan H
ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Alan Fairlamb (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Perez-Pineiro Rolando; Burgos Asdrubal; Jones Deuan C; Andrew Lena C; Rodriguez Hortensia; Suarez Margarita; Fairlamb Alan H; Wishart David S
Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.
Journal of medicinal chemistry 2009;52(6):1670-80.
2009: Greig Neil; Wyllie Susan; Patterson Stephen; Fairlamb Alan H
A comparative study of methylglyoxal metabolism in trypanosomatids.
The FEBS journal 2009;276(2):376-86.
2008: Oza Sandra L; Chen Shoujun; Wyllie Susan; Coward James K; Fairlamb Alan H
ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.
The FEBS journal 2008;275(21):5408-21.
2008: Alphey Magnus S; König Janine; Fairlamb Alan H
Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases.
The Biochemical journal 2008;414(3):375-81.
2008: Sienkiewicz Natasha; Jaroslawski Szymon; Wyllie Susan; Fairlamb Alan H
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.
Molecular microbiology 2008;69(2):520-33.
2008: Fyfe Paul K; Oza Sandra L; Fairlamb Alan H; Hunter William N
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities.
The Journal of biological chemistry 2008;283(25):17672-80.
2008: Gallo Margareth B C; Marques Anna Sylvia F; Vieira Paulo C; da Silva Maria Fátima das G F; Fernandes João B; Silva Márcio; Guido Rafael V; Oliva Glaucius; Thiemann Otávio H; Albuquerque Sérgio; Fairlamb Alan H
Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.
Zeitschrift für Naturforschung. C, Journal of biosciences 2008;63(5-6):371-82.
2008: Stuart Ken; Brun Reto; Croft Simon; Fairlamb Alan; Gürtler Ricardo E; McKerrow Jim; Reed Steve; Tarleton Rick
Kinetoplastids: related protozoan pathogens, different diseases.
The Journal of clinical investigation 2008;118(4):1301-10.
2008: Wyllie Susan; Vickers Tim J; Fairlamb Alan H
Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials.
Antimicrobial agents and chemotherapy 2008;52(4):1359-65.
2007: Frearson Julie A; Wyatt Paul G; Gilbert Ian H; Fairlamb Alan H
Target assessment for antiparasitic drug discovery.
Trends in parasitology 2007;23(12):589-95.
2007: König Janine; Fairlamb Alan H
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
The FEBS journal 2007;274(21):5643-58.
2007: Mandal G; Wyllie S; Singh N; Sundar S; Fairlamb A H; Chatterjee M
Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony.
Parasitology 2007;134(Pt 12):1679-87.
2007: Caffrey Conor R; Steverding Dietmar; Swenerton Ryan K; Kelly Ben; Walshe Deirdre; Debnath Anjan; Zhou Yuan-Min; Doyle Patricia S; Fafarman Aaron T; Zorn Julie A; Land Kirkwood M; Beauchene Jessica; Schreiber Kimberly; Moll Heidrun; Ponte-Sucre Alicia; Schirmeister Tanja; Saravanamuthu Ahilan; Fairlamb Alan H; Cohen Fred E; McKerrow James H; Weisman Jennifer L; May Barnaby C H
Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Antimicrobial agents and chemotherapy 2007;51(6):2164-72.
2007: Martyn Derek C; Jones Deuan C; Fairlamb Alan H; Clardy Jon
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Bioorganic & medicinal chemistry letters 2007;17(5):1280-3.
2007: Holloway Georgina A; Baell Jonathan B; Fairlamb Alan H; Novello Patrizia M; Parisot John P; Richardson John; Watson Keith G; Street Ian P
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.
Bioorganic & medicinal chemistry letters 2007;17(5):1422-7.
2006: Greig Neil; Wyllie Susan; Vickers Tim J; Fairlamb Alan H
Trypanothione-dependent glyoxalase I in Trypanosoma cruzi.
The Biochemical journal 2006;400(2):217-23.
2006: Dawson Alice; Gibellini Federica; Sienkiewicz Natasha; Tulloch Lindsay B; Fyfe Paul K; McLuskey Karen; Fairlamb Alan H; Hunter William N
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.
Molecular microbiology 2006;61(6):1457-68.
2006: Oza Sandra L; Wyllie Susan; Fairlamb Alan H
Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major.
Molecular and biochemical parasitology 2006;149(1):117-20.
2006: Hamilton Chris J; Saravanamuthu Ahilan; Poupat Christiane; Fairlamb Alan H; Eggleston Ian M
Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products.
Bioorganic & medicinal chemistry 2006;14(7):2266-78.
2006: Wyllie Susan; Fairlamb Alan H
Refinement of techniques for the propagation of Leishmania donovani in hamsters.
Acta tropica 2006;97(3):364-9.
2006: Ariza Antonio; Vickers Tim J; Greig Neil; Armour Kirsten A; Dixon Mark J; Eggleston Ian M; Fairlamb Alan H; Bond Charles S
Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme.
Molecular microbiology 2006;59(4):1239-48.
2006: Croft Simon L; Sundar Shyam; Fairlamb Alan H
Drug resistance in leishmaniasis.
Clinical microbiology reviews 2006;19(1):111-26.
2006: Wyllie Susan; Fairlamb Alan H
Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line.
Biochemical pharmacology 2006;71(3):257-67.
2006: Wickramasinghe Sasala R; Inglis Kirstine A; Urch Jonathan E; Müller Sylke; van Aalten Daan M F; Fairlamb Alan H
Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis.
The Biochemical journal 2006;393(Pt 2):447-57.
2005: Smith Aaron T; Tucker-Samaras Samantha D; Fairlamb Alan H; Sullivan William J
MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii.
Eukaryotic cell 2005;4(12):2057-65.
2005: Ariyanayagam Mark R; Oza Sandra L; Guther Maria Lucia S; Fairlamb Alan H
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome.
The Biochemical journal 2005;391(Pt 2):425-32.
2005: Ariza Antonio; Vickers Tim J; Greig Neil; Fairlamb Alan H; Bond Charles S
Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 8):769-72.
2005: Berriman Matthew; Ghedin Elodie; Hertz-Fowler Christiane; Blandin Gaëlle; Renauld Hubert; Bartholomeu Daniella C; Lennard Nicola J; Caler Elisabet; Hamlin Nancy E; Haas Brian; Böhme Ulrike; Hannick Linda; Aslett Martin A; Shallom Joshua; Marcello Lucio; Hou Lihua; Wickstead Bill; Alsmark U Cecilia M; Arrowsmith Claire; Atkin Rebecca J; Barron Andrew J; Bringaud Frederic; Brooks Karen; Carrington Mark; Cherevach Inna; Chillingworth Tracey-Jane; Churcher Carol; Clark Louise N; Corton Craig H; Cronin Ann; Davies Rob M; Doggett Jonathon; Djikeng Appolinaire; Feldblyum Tamara; Field Mark C; Fraser Audrey; Goodhead Ian; Hance Zahra; Harper David; Harris Barbara R; Hauser Heidi; Hostetler Jessica; Ivens Al; Jagels Kay; Johnson David; Johnson Justin; Jones Kristine; Kerhornou Arnaud X; Koo Hean; Larke Natasha; Landfear Scott; Larkin Christopher; Leech Vanessa; Line Alexandra; Lord Angela; Macleod Annette; Mooney Paul J; Moule Sharon; Martin David M A; Morgan Gareth W; Mungall Karen; Norbertczak Halina; Ormond Doug; Pai Grace; Peacock Chris S; Peterson Jeremy; Quail Michael A; Rabbinowitsch Ester; Rajandream Marie-Adele; Reitter Chris; Salzberg Steven L; Sanders Mandy; Schobel Seth; Sharp Sarah; Simmonds Mark; Simpson Anjana J; Tallon Luke; Turner C Michael R; Tait Andrew; Tivey Adrian R; Van Aken Susan; Walker Danielle; Wanless David; Wang Shiliang; White Brian; White Owen; Whitehead Sally; Woodward John; Wortman Jennifer; Adams Mark D; Embley T Martin; Gull Keith; Ullu Elisabetta; Barry J David; Fairlamb Alan H; Opperdoes Fred; Barrell Barclay G; Donelson John E; Hall Neil; Fraser Claire M; Melville Sara E; El-Sayed Najib M
The genome of the African trypanosome Trypanosoma brucei.
Science (New York, N.Y.) 2005;309(5733):416-22.
2005: Oza Sandra L; Shaw Matthew P; Wyllie Susan; Fairlamb Alan H
Trypanothione biosynthesis in Leishmania major.
Molecular and biochemical parasitology 2005;139(1):107-16.
2004: Vickers Tim J; Wyllie Susan; Fairlamb Alan H
Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activity.
The Journal of biological chemistry 2004;279(47):49003-9.
2004: Vickers Tim J; Greig Neil; Fairlamb Alan H
A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13186-91.
2004: Wyllie Susan; Cunningham Mark L; Fairlamb Alan H
Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani.
The Journal of biological chemistry 2004;279(38):39925-32.
2004: Saravanamuthu Ahilan; Vickers Tim J; Bond Charles S; Peterson Mark R; Hunter William N; Fairlamb Alan H
Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design.
The Journal of biological chemistry 2004;279(28):29493-500.
2004: Vickers Tim J; Fairlamb Alan H
Trypanothione S-transferase activity in a trypanosomatid ribosomal elongation factor 1B.
The Journal of biological chemistry 2004;279(26):27246-56.
2003: Fairlamb Alan H
Chemotherapy of human African trypanosomiasis: current and future prospects.
Trends in parasitology 2003;19(11):488-94.
2003: Oza Sandra L; Ariyanayagam Mark R; Aitcheson Niall; Fairlamb Alan H
Properties of trypanothione synthetase from Trypanosoma brucei.
Molecular and biochemical parasitology 2003;131(1):25-33.
2003: Hamilton Chris J; Saravanamuthu Ahilan; Fairlamb Alan H; Eggleston Ian M
Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase.
Bioorganic & medicinal chemistry 2003;11(17):3683-93.
2003: Ariyanayagam Mark R; Oza Sandra L; Mehlert Angela; Fairlamb Alan H
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
The Journal of biological chemistry 2003;278(30):27612-9.
2003: Alphey Magnus S; Gabrielsen Mads; Micossi Elena; Leonard Gordon A; McSweeney Sean M; Ravelli Raimond B G; Tetaud Emmanuel; Fairlamb Alan H; Bond Charles S; Hunter William N
Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function.
The Journal of biological chemistry 2003;278(28):25919-25.
2003: Zani Carlos L; Fairlamb Alan H
8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase.
Memórias do Instituto Oswaldo Cruz 2003;98(4):565-8.
2003: Sarkar Mitali; Hamilton Christopher J; Fairlamb Alan H
Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi.
The Journal of biological chemistry 2003;278(25):22703-8.
2003: Aliberti Julio; Valenzuela Jesus G; Carruthers Vern B; Hieny Sara; Andersen John; Charest Hugues; Reis e Sousa Caetano; Fairlamb Alan; Ribeiro Jose M; Sher Alan
Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells.
Nature immunology 2003;4(5):485-90.
2003: Hamilton Chris J; Saravanamuthu Ahilan; Eggleston Ian M; Fairlamb Alan H
Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase.
The Biochemical journal 2003;369(Pt 3):529-37.
2002: Gardner Malcolm J; Hall Neil; Fung Eula; White Owen; Berriman Matthew; Hyman Richard W; Carlton Jane M; Pain Arnab; Nelson Karen E; Bowman Sharen; Paulsen Ian T; James Keith; Eisen Jonathan A; Rutherford Kim; Salzberg Steven L; Craig Alister; Kyes Sue; Chan Man-Suen; Nene Vishvanath; Shallom Shamira J; Suh Bernard; Peterson Jeremy; Angiuoli Sam; Pertea Mihaela; Allen Jonathan; Selengut Jeremy; Haft Daniel; Mather Michael W; Vaidya Akhil B; Martin David M A; Fairlamb Alan H; Fraunholz Martin J; Roos David S; Ralph Stuart A; McFadden Geoffrey I; Cummings Leda M; Subramanian G Mani; Mungall Chris; Venter J Craig; Carucci Daniel J; Hoffman Stephen L; Newbold Chris; Davis Ronald W; Fraser Claire M; Barrell Bart
Genome sequence of the human malaria parasite Plasmodium falciparum.
Nature 2002;419(6906):498-511.
2002: Amssoms Katie; Oza Sandra L; Augustyns Koen; Yamani Abdellah; Lambeir Anne-Marie; Bal Gunther; Van der Veken Pieter; Fairlamb Alan H; Haemers Achiel
Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part.
Bioorganic & medicinal chemistry letters 2002;12(19):2703-5.
2002: Amssoms Katie; Oza Sandra L; Ravaschino Esteban; Yamani Abdellah; Lambeir Anne; Rajan Padinchare; Bal Gunther; Rodriguez Juan; Fairlamb Alan H; Augustyns Koen; Haemers Achiel
Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group.
Bioorganic & medicinal chemistry letters 2002;12(18):2553-6.
2002: Oza Sandra L; Tetaud Emmanuel; Ariyanayagam Mark R; Warnon Stephanie S; Fairlamb Alan H
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
The Journal of biological chemistry 2002;277(39):35853-61.
2002: Chan C; Yin H; McKie J H; Fairlamb A H; Douglas K T
Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead.
Amino acids 2002;22(4):297-308.
2002: Oza Sandra L; Ariyanayagam Mark R; Fairlamb Alan H
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
The Biochemical journal 2002;364(Pt 3):679-86.
2002: Tetaud Emmanuel; Lecuix Isabelle; Sheldrake Tara; Baltz Théo; Fairlamb Alan H
A new expression vector for Crithidia fasciculata and Leishmania.
Molecular and biochemical parasitology 2002;120(2):195-204.
2002: Fairlamb Alan H
Metabolic pathway analysis in trypanosomes and malaria parasites.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2002;357(1417):101-7.
2001: Chibale K; Haupt H; Kendrick H; Yardley V; Saravanamuthu A; Fairlamb A H; Croft S L
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.
Bioorganic & medicinal chemistry letters 2001;11(19):2655-7.
2001: Tetaud E; Giroud C; Prescott A R; Parkin D W; Baltz D; Biteau N; Baltz T; Fairlamb A H
Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei.
Molecular and biochemical parasitology 2001;116(2):171-83.
2001: Ariyanayagam M R; Fairlamb A H
Ovothiol and trypanothione as antioxidants in trypanosomatids.
Molecular and biochemical parasitology 2001;115(2):189-98.
2001: Fairlamb A H
Brave new world of post-genomics!
Trends in parasitology 2001;17(6):255-6.
2001: Gutierrez-Correa J; Fairlamb A H; Stoppani A O
Trypanosoma cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals.
Free radical research 2001;34(4):363-78.
2001: Maldonado R A; Fairlamb A H
Cloning of a pyruvate phosphate dikinase from Trypanosoma cruzi.
Molecular and biochemical parasitology 2001;112(2):183-91.
2001: Gutierrez Correa J; Fairlamb A H; Stoppani A O
[Inactivation of Trypanosoma cruzi trypanothione reductase by phenothiazine cationic free radicals]
Revista Argentina de microbiología 2001;33(1):36-46.
2001: McKie J H; Garforth J; Jaouhari R; Chan C; Yin H; Besheya T; Fairlamb A H; Douglas K T
Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks.
Amino acids 2001;20(2):145-53.
2000: Robertson L; Robertson W M; Sobczak M; Helder J; Tetaud E; Ariyanayagam M R; Ferguson M A; Fairlamb A; Jones J T
Cloning, expression and functional characterisation of a peroxiredoxin from the potato cyst nematode Globodera rostochiensis.
Molecular and biochemical parasitology 2000;111(1):41-9.
2000: Alphey M S; Bond C S; Tetaud E; Fairlamb A H; Hunter W N
The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins.
Journal of molecular biology 2000;300(4):903-16.
2000: Chibale K; Visser M; Yardley V; Croft S L; Fairlamb A H
Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani.
Bioorganic & medicinal chemistry letters 2000;10(11):1147-50.
2000: Peterson M R; Hall D R; Berriman M; Nunes J A; Leonard G A; Fairlamb A H; Hunter W N
The three-dimensional structure of a Plasmodium falciparum cyclophilin in complex with the potent anti-malarial cyclosporin A.
Journal of molecular biology 2000;298(1):123-33.
2000: Barrett M P; Fairlamb A H; Rousseau B; Chauvière G; Perié J
Uptake of the nitroimidazole drug megazol by African trypanosomes.
Biochemical pharmacology 2000;59(6):615-20.
2000: Krieger S; Schwarz W; Ariyanayagam M R; Fairlamb A H; Krauth-Siegel R L; Clayton C
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress.
Molecular microbiology 2000;35(3):542-52.
1999: Vial H J; Traore M; Fairlamb A H; Ridley R G
Renewed strategies for drug development against parasitic diseases.
Parasitology today (Personal ed.) 1999;15(10):393-4.
1999: Ariyanayagam M R; Fairlamb A H
Entamoeba histolytica lacks trypanothione metabolism.
Molecular and biochemical parasitology 1999;103(1):61-9.
1999: Alphey M S; Leonard G A; Gourley D G; Tetaud E; Fairlamb A H; Hunter W N
The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I.
The Journal of biological chemistry 1999;274(36):25613-22.
1999: Alphey M S; Tetaud E; Gourley D G; Fairlamb A H; Hunter W N
Crystallization of recombinant Crithidia fasciculata tryparedoxin.
Journal of structural biology 1999;126(1):76-9.
1999: Dobson S; May T; Berriman M; Del Vecchio C; Fairlamb A H; Chakrabarti D; Barik S
Characterization of protein Ser/Thr phosphatases of the malaria parasite, Plasmodium falciparum: inhibition of the parasitic calcineurin by cyclophilin-cyclosporin complex.
Molecular and biochemical parasitology 1999;99(2):167-81.
1999: Barrett M P; Fairlamb A H
The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes.
Parasitology today (Personal ed.) 1999;15(4):136-40.
1999: Jiang Y; Roberts S C; Jardim A; Carter N S; Shih S; Ariyanayagam M; Fairlamb A H; Ullman B
Ornithine decarboxylase gene deletion mutants of Leishmania donovani.
The Journal of biological chemistry 1999;274(6):3781-8.
1999: Bond C S; Zhang Y; Berriman M; Cunningham M L; Fairlamb A H; Hunter W N
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
Structure (London, England : 1993) 1999;7(1):81-9.
1999: Fairlamb A H
Future prospects for the chemotherapy of Chagas' disease.
Medicina 1999;59 Suppl 2():179-87.
1999: Yuen C T; Garforth J; Besheya T; Jaouhari R; McKie J H; Fairlamb A H; Douglas K T
Synthesis and enzymology of modified N-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide++ + disulphides as alternative substrates for trypanothione reductase from Trypanosoma cruzi: Part 3.
Amino acids 1999;17(2):175-83.
1998: Bouma M J; Snowdon D; Fairlamb A H; Ackers J P
Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus.
The Journal of antimicrobial chemotherapy 1998;42(6):817-20.
1998: Ariyanayagam M R; Tetaud E; Fairlamb A H
Diamine auxotrophy in a eukaryotic parasite.
Biochemical Society transactions 1998;26(4):606-9.
1998: Levick M P; Tetaud E; Fairlamb A H; Blackwell J M
Identification and characterisation of a functional peroxidoxin from Leishmania major.
Molecular and biochemical parasitology 1998;96(1-2):125-37.
1998: Tetaud E; Fairlamb A H
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
Molecular and biochemical parasitology 1998;96(1-2):111-23.
1998: Berriman M; Fairlamb A H
Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum.
The Biochemical journal 1998;334 ( Pt 2)():437-45.
1998: Tovar J; Wilkinson S; Mottram J C; Fairlamb A H
Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus.
Molecular microbiology 1998;29(2):653-60.
1998: Tetaud E; Manai F; Barrett M P; Nadeau K; Walsh C T; Fairlamb A H
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
The Journal of biological chemistry 1998;273(31):19383-90.
1998: Tye C K; Kasinathan G; Barrett M P; Brun R; Doyle V E; Fairlamb A H; Weaver R; Gilbert I H
An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.
Bioorganic & medicinal chemistry letters 1998;8(7):811-6.
1998: Tovar J; Cunningham M L; Smith A C; Croft S L; Fairlamb A H
Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5311-6.
1998: Chan C; Yin H; Garforth J; McKie J H; Jaouhari R; Speers P; Douglas K T; Rock P J; Yardley V; Croft S L; Fairlamb A H
Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
Journal of medicinal chemistry 1998;41(2):148-56.
1998: Borst P; Fairlamb A H
Surface receptors and transporters of Trypanosoma brucei.
Annual review of microbiology 1998;52():745-78.
1998: Le Quesne S A; Fairlamb A H
Measurement of polyamine transport. Cells in suspension.
Methods in molecular biology (Clifton, N.J.) 1998;79():149-56.
1998: Hunter K J; Fairlamb A H
The determination of polyamines and amino acids by a fluorescamine-HPLC method.
Methods in molecular biology (Clifton, N.J.) 1998;79():125-30.
1997: Zani C L; Chiari E; Krettli A U; Murta S M; Cunningham M L; Fairlamb A H; Romanha A J
Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiopen-4,9-quinones.
Bioorganic & medicinal chemistry 1997;5(12):2185-92.
1997: Garforth J; Yin H; McKie J H; Douglas K T; Fairlamb A H
Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine.
Journal of enzyme inhibition 1997;12(3):161-73.
1997: Müller S; Gilberger T W; Fairlamb A H; Walter R D
Molecular characterization and expression of Onchocerca volvulus glutathione reductase.
The Biochemical journal 1997;325 ( Pt 3)():645-51.
1997: Dumas C; Ouellette M; Tovar J; Cunningham M L; Fairlamb A H; Tamar S; Olivier M; Papadopoulou B
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.
The EMBO journal 1997;16(10):2590-8.
1997: Ariyanayagam M R; Fairlamb A H
Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes.
Molecular and biochemical parasitology 1997;84(1):111-21.
1997: De Craecker S; Verbruggen C; Rajan P K; Smith K; Haemers A; Fairlamb A H
Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata.
Molecular and biochemical parasitology 1997;84(1):25-32.
1996: Tovar J; Fairlamb A H
Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi.
Nucleic acids research 1996;24(15):2942-9.
1996: Le Quesne S A; Fairlamb A H
Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes.
The Biochemical journal 1996;316 ( Pt 2)():481-6.
1996: Zhang Y; Bond C S; Bailey S; Cunningham M L; Fairlamb A H; Hunter W N
The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.
Protein science : a publication of the Protein Society 1996;5(1):52-61.
1995: Berger B J; Martiney J; Slater A F; Fairlamb A H; Cerami A
Chloroquine resistance is not associated with drug metabolism in Plasmodium falciparum.
The Journal of parasitology 1995;81(6):1004-8.
1995: Smith K; Borges A; Ariyanayagam M R; Fairlamb A H
Glutathionylspermidine metabolism in Escherichia coli.
The Biochemical journal 1995;312 ( Pt 2)():465-9.
1995: Chan C; Yin H; Garforth J; McKie J H; Jaouhari R A; Douglas K T; Fairlamb A H; Croft S L
Inhibitors of trypanothione reductase as potential antitrypanosomal drugs.
Biochemical Society transactions 1995;23(4):511S.
1995: Carter N S; Berger B J; Fairlamb A H
Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei.
The Journal of biological chemistry 1995;270(47):28153-7.
1995: Leonard G A; Hunter W N; Berger B J; Fairlamb A H
p-(4,6-Diamino-s-triazin-2-yl)aminophenylarsonic acid dihydrate.
Acta crystallographica. Section C, Crystal structure communications 1995;51(Pt 9):1953-5.
1995: Bond C S; Fairlamb A H; Hunter W N
A comparison of two independently determined structures of trypanothione reductase from Crithidia fasciculata.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 4):567-74.
1995: Rifkin M R; Strobos C A; Fairlamb A H
Specificity of ethanolamine transport and its further metabolism in Trypanosoma brucei.
The Journal of biological chemistry 1995;270(27):16160-6.
1995: Cunningham M L; Fairlamb A H
Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.
European journal of biochemistry / FEBS 1995;230(2):460-8.
1995: Müller S; Walter R D; Fairlamb A H
Differential susceptibility of filarial and human erythrocyte glutathione reductase to inhibition by the trivalent organic arsenical melarsen oxide.
Molecular and biochemical parasitology 1995;71(2):211-9.
1995: Borges A; Cunningham M L; Tovar J; Fairlamb A H
Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.
European journal of biochemistry / FEBS 1995;228(3):745-52.
1995: Berger B J; Carter N S; Fairlamb A H
Characterisation of pentamidine-resistant Trypanosoma brucei brucei.
Molecular and biochemical parasitology 1995;69(2):289-98.
1994: Hunter K J; Le Quesne S A; Fairlamb A H
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
European journal of biochemistry / FEBS 1994;226(3):1019-27.
1994: Berger B J; Fairlamb A H
Properties of melarsamine hydrochloride (Cymelarsan) in aqueous solution.
Antimicrobial agents and chemotherapy 1994;38(6):1298-302.
1994: Berger B J; Fairlamb A H
High-performance liquid chromatographic method for the separation and quantitative estimation of anti-parasitic melaminophenyl arsenical compounds.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88(3):357-9.
1994: Cunningham M L; Zvelebil M J; Fairlamb A H
Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals.
European journal of biochemistry / FEBS 1994;221(1):285-95.
1994: Taylor M C; Kelly J M; Chapman C J; Fairlamb A H; Miles M A
The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase.
Molecular and biochemical parasitology 1994;64(2):293-301.
1994: Bailey S; Fairlamb A H; Hunter W N
Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 2):139-54.
1994: Kairo A; Fairlamb A H; Gobright E; Nene V
A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially encoded proteins.
The EMBO journal 1994;13(4):898-905.
1993: Kelly J M; Taylor M C; Smith K; Hunter K J; Fairlamb A H
Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress.
European journal of biochemistry / FEBS 1993;218(1):29-37.
1993: el-Waer A F; Smith K; McKie J H; Benson T; Fairlamb A H; Douglas K T
The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues.
Biochimica et biophysica acta 1993;1203(1):93-8.
1993: Berger B J; Carter N S; Fairlamb A H
Polyamine and pentamidine metabolism in African trypanosomes.
Acta tropica 1993;54(3-4):215-24.
1993: Zhang Y; Bailey S; Naismith J H; Bond C S; Habash J; McLaughlin P; Papiz M Z; Borges A; Cunningham M; Fairlamb A H
Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution.
Journal of molecular biology 1993;232(4):1217-20.
1993: Berger B J; Fairlamb A H
Cytochrome P450 in trypanosomatids.
Biochemical pharmacology 1993;46(1):149-57.
1993: Bailey S; Smith K; Fairlamb A H; Hunter W N
Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution.
European journal of biochemistry / FEBS 1993;213(1):67-75.
1993: Carter N S; Fairlamb A H
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
Nature 1993;361(6408):173-6.
1992: Aboagye-Kwarteng T; Smith K; Fairlamb A H
Molecular characterization of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei: comparison with other flavoprotein disulphide oxidoreductases with respect to substrate specificity and catalytic mechanism.
Molecular microbiology 1992;6(21):3089-99.
1992: Hunter W N; Bailey S; Habash J; Harrop S J; Helliwell J R; Aboagye-Kwarteng T; Smith K; Fairlamb A H
Active site of trypanothione reductase. A target for rational drug design.
Journal of molecular biology 1992;227(1):322-33.
1992: Benson T J; McKie J H; Garforth J; Borges A; Fairlamb A H; Douglas K T
Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.
The Biochemical journal 1992;286 ( Pt 1)():9-11.
1992: Fairlamb A H; Smith K; Hunter K J
The interaction of arsenical drugs with dihydrolipoamide and dihydrolipoamide dehydrogenase from arsenical resistant and sensitive strains of Trypanosoma brucei brucei.
Molecular and biochemical parasitology 1992;53(1-2):223-31.
1992: Fairlamb A H; Carter N S; Cunningham M; Smith K
Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism.
Molecular and biochemical parasitology 1992;53(1-2):213-22.
1992: Smith K; Nadeau K; Bradley M; Walsh C; Fairlamb A H
Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata.
Protein science : a publication of the Protein Society 1992;1(7):874-83.
1992: Komuniecki R; Bruchhaus I; Ilg T; Wilson K; Zhang Y; Fairlamb A H
Purification of glutathione reductase from muscle of the adult parasitic nematode Ascaris suum.
Molecular and biochemical parasitology 1992;51(2):331-3.
1992: Fairlamb A H; Cerami A
Metabolism and functions of trypanothione in the Kinetoplastida.
Annual review of microbiology 1992;46():695-729.
1992: Berger B J; Fairlamb A H
Interactions between immunity and chemotherapy in the treatment of the trypanosomiases and leishmaniases.
Parasitology 1992;105 Suppl():S71-8.
1991: el-Waer A; Douglas K T; Smith K; Fairlamb A H
Synthesis of N-benzyloxycarbonyl-L-cysteinylglycine 3-dimethylaminopropylamide disulfide: a cheap and convenient new assay for trypanothione reductase.
Analytical biochemistry 1991;198(1):212-6.
1991: Smith K; Opperdoes F R; Fairlamb A H
Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei.
Molecular and biochemical parasitology 1991;48(1):109-12.
1991: Hunter K J; Strobos C A; Fairlamb A H
Inhibition of polyamine biosynthesis in Crithidia fasciculata by D,L-alpha-difluoromethylornithine and D,L-alpha-difluoromethylarginine.
Molecular and biochemical parasitology 1991;46(1):35-43.
1990: Hunter K J; Strobos C A; Fairlamb A H
The interaction of trypanocidal drugs with polyamine and trypanothione metabolism.
Biochemical Society transactions 1990;18(6):1094-6.
1990: Hunter K J; Fairlamb A H
Separation and quantitation of the polyamine biosynthesis inhibitor D,L-alpha-difluoromethylarginine and other guanidine-containing compounds by high-performance liquid chromatography.
Analytical biochemistry 1990;190(2):281-5.
1990: Hunter W N; Smith K; Derewenda Z; Harrop S J; Habash J; Islam M S; Helliwell J R; Fairlamb A H
Initiating a crystallographic study of trypanothione reductase.
Journal of molecular biology 1990;216(2):235-7.
1990: Taylor M C; Kelly J M; Fairlamb A H; Miles M A
The trypanothione reductase gene of Leishmania donovani.
Biochemical Society transactions 1990;18(5):869-70.
1990: Fairlamb A H
Trypanothione metabolism and rational approaches to drug design.
Biochemical Society transactions 1990;18(5):717-20.
1990: Fairlamb A H
Future prospects for the chemotherapy of human trypanosomiasis. 1. Novel approaches to the chemotherapy of trypanosomiasis.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(5):613-7.
1990: Henderson G B; Yamaguchi M; Novoa L; Fairlamb A H; Cerami A
Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata.
Biochemistry 1990;29(16):3924-9.
1989: Fairlamb A H; Henderson G B; Cerami A
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2607-11.
1989: Fairlamb A H
Novel biochemical pathways in parasitic protozoa.
Parasitology 1989;99 Suppl():S93-112.
1988: Henderson G B; Ulrich P; Fairlamb A H; Rosenberg I; Pereira M; Sela M; Cerami A
"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5374-8.
1988: Shim H; Fairlamb A H
Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata.
Journal of general microbiology 1988;134(3):807-17.
1988: Fairlamb A H
The role of glutathionylspermidine and trypanothione in regulation of intracellular spermidine levels during growth of Crithidia fasciculata.
Advances in experimental medicine and biology 1988;250():667-74.
1987: Henderson G B; Fairlamb A H
Trypanothione metabolism: a chemotherapeutic target in trypanosomatids.
Parasitology today (Personal ed.) 1987;3(10):312-5.
1987: Bellofatto V; Fairlamb A H; Henderson G B; Cross G A
Biochemical changes associated with alpha-difluoromethylornithine uptake and resistance in Trypanosoma brucei.
Molecular and biochemical parasitology 1987;25(3):227-38.
1987: Henderson G B; Fairlamb A H; Ulrich P; Cerami A
Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata.
Biochemistry 1987;26(11):3023-7.
1987: Fairlamb A H; Henderson G B; Bacchi C J; Cerami A
In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.
Molecular and biochemical parasitology 1987;24(2):185-91.
1987: Henderson G B; Fairlamb A H; Cerami A
Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei.
Molecular and biochemical parasitology 1987;24(1):39-45.
1987: Krauth-Siegel R L; Enders B; Henderson G B; Fairlamb A H; Schirmer R H
Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.
European journal of biochemistry / FEBS 1987;164(1):123-8.
1986: Fairlamb A H; Henderson G B; Cerami A
The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata.
Molecular and biochemical parasitology 1986;21(3):247-57.
1986: Shames S L; Fairlamb A H; Cerami A; Walsh C T
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases.
Biochemistry 1986;25(12):3519-26.
1985: Fairlamb A H; Warhurst D C; Peters W
An improved technique for the cultivation of Plasmodium falciparum in vitro without daily medium change.
Annals of tropical medicine and parasitology 1985;79(4):379-84.
1985: Rifkin M R; Fairlamb A H
Transport of ethanolamine and its incorporation into the variant surface glycoprotein of bloodstream forms of Trypanosoma brucei.
Molecular and biochemical parasitology 1985;15(3):245-56.
1985: Fairlamb A H; Blackburn P; Ulrich P; Chait B T; Cerami A
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids.
Science (New York, N.Y.) 1985;227(4693):1485-7.
1985: Fairlamb A H; Cerami A
Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids.
Molecular and biochemical parasitology 1985;14(2):187-98.
1984: Fairlamb A H; Paul F; Warhurst D C
A simple magnetic method for the purification of malarial pigment.
Molecular and biochemical parasitology 1984;12(3):307-12.
1984: Hotez P J; Le Trang N; Fairlamb A H; Cerami A
Lipoprotein lipase suppression in 3T3-L1 cells by a haematoprotozoan-induced mediator from peritoneal exudate cells.
Parasite immunology 1984;6(3):203-9.
1980: Fairlamb A H; Bowman I B
Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo.
Molecular and biochemical parasitology 1980;1(6):315-33.
1980: Fairlamb A H; Bowman I B
An improved method for the estimation of suramin in plasma and trypanosome samples.
Molecular and biochemical parasitology 1980;1(6):307-13.
1980: Fairlamb A H; Bowman I B
Trypanosoma brucei: maintenance of concentrated suspensions of bloodstream trypomastigotes in vitro using continuous dialysis for measurement of endocytosis.
Experimental parasitology 1980;49(3):366-80.
1978: Fairlamb A H; Weislogel P O; Hoeijmakers J H; Borst P
Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei.
The Journal of cell biology 1978;76(2):293-309.
1977: Fairlamb A H; Bowman I B
Trypanosoma brucei: suramin and other trypanocidal compounds' effects on sn-glycerol-3-phosphate oxidase.
Experimental parasitology 1977;43(2):353-61.
1977: Weislogel P O; Hoeijmakers J H; Fairlamb A H; Kleisen C M; Borst P
Characterization of kinetoplast DNA networks from the insect trypanosome Crithidia luciliae.
Biochimica et biophysica acta 1977;478(2):167-79.
1977: Fairlamb A H; Opperdoes F R; Borst P
New approach to screening drugs for activity against African trypanosomes.
Nature 1977;265(5591):270-1.
1974: Fairlamb A H; Bowman I B
Cell disruption and subcellular fractionation of Trypanosoma brucei.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1974;68(4):275.

Sign-in to see more