Huda Akil

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Akil Huda; Watson Stanley J; Dalack Gregory W; Greden John F; Zubieta Jon-Kar
In memory of Elizabeth Young.
Evans Simon J; Akil Huda; Watson Stanley J
Analyzing gene expression in depression.
Perez Javier A; Clinton Sarah M; Turner Cortney A; Watson Stanley J; Akil Huda
A new role for FGF2 as an endogenous inhibitor of anxiety.

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All Publications

2009: Akil Huda; Watson Stanley J; Dalack Gregory W; Greden John F; Zubieta Jon-Kar
In memory of Elizabeth Young.
Biological psychiatry 2009;66(11):e25-6.
2009: Evans Simon J; Akil Huda; Watson Stanley J
Analyzing gene expression in depression.
The American journal of psychiatry 2009;166(9):961-3.
2009: Perez Javier A; Clinton Sarah M; Turner Cortney A; Watson Stanley J; Akil Huda
A new role for FGF2 as an endogenous inhibitor of anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(19):6379-87.
2009: García-Fuster María-Julia; Clinton Sarah M; Watson Stanley J; Akil Huda
Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(5):1123-34.
2009: Bernard René; Kerman Ilan A; Meng Fan; Evans Simon J; Amrein Irmgard; Jones Edward G; Bunney William E; Akil Huda; Watson Stanley J; Thompson Robert C
Gene expression profiling of neurochemically defined regions of the human brain by in situ hybridization-guided laser capture microdissection.
Journal of neuroscience methods 2009;178(1):46-54.
2009: Turner Cortney A; Capriles Nancy; Flagel Shelly B; Perez Javier A; Clinton Sarah M; Watson Stanley J; Akil Huda
Neonatal FGF2 alters cocaine self-administration in the adult rat.
Pharmacology, biochemistry, and behavior 2009;92(1):100-4.
2009: Martin Maureen V; Rollins Brandi; Sequeira P Adolfo; Mesén Andrea; Byerley William; Stein Richard; Moon Emily A; Akil Huda; Jones Edward G; Watson Stanley J; Barchas Jack; DeLisi Lynn E; Myers Richard M; Schatzberg Alan; Bunney William E; Vawter Marquis P
Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation.
BMC medical genomics 2009;2():62.
2009: Rollins Brandi; Martin Maureen V; Sequeira P Adolfo; Moon Emily A; Morgan Ling Z; Watson Stanley J; Schatzberg Alan; Akil Huda; Myers Richard M; Jones Edward G; Wallace Douglas C; Bunney William E; Vawter Marquis P
Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder.
PloS one 2009;4(3):e4913.
2009: Wright Sara L; Langenecker Scott A; Deldin Patricia J; Rapport Lisa J; Nielson Kristy A; Kade Allison M; Own Lawrence S; Akil Huda; Young Elizabeth A; Zubieta Jon-Kar
Gender-specific disruptions in emotion processing in younger adults with depression.
Depression and anxiety 2009;26(2):182-9.
2009: Flagel Shelly B; Akil Huda; Robinson Terry E
Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction.
Neuropharmacology 2009;56 Suppl 1():139-48.
2008: Turner Cortney A; Flagel Shelly B; Clinton Sarah M; Akil Huda; Watson Stanley J
Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the rat.
Neuroscience letters 2008;446(2-3):105-7.
2008: Cecchi M; Capriles N; Watson S J; Akil H
Differential responses to morphine-induced analgesia in the tail-flick test.
Behavioural brain research 2008;194(2):146-51.
2008: Briand Lisa A; Flagel Shelly B; Garcia-Fuster M Julia; Watson Stanley J; Akil Huda; Sarter Martin; Robinson Terry E
Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(12):2969-80.
2008: Gardner Daniel; Akil Huda; Ascoli Giorgio A; Bowden Douglas M; Bug William; Donohue Duncan E; Goldberg David H; Grafstein Bernice; Grethe Jeffrey S; Gupta Amarnath; Halavi Maryam; Kennedy David N; Marenco Luis; Martone Maryann E; Miller Perry L; Müller Hans-Michael; Robert Adrian; Shepherd Gordon M; Sternberg Paul W; Van Essen David C; Williams Robert W
The neuroscience information framework: a data and knowledge environment for neuroscience.
Neuroinformatics 2008;6(3):149-60.
2008: Davis Brooke A; Clinton Sarah M; Akil Huda; Becker Jill B
The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred High-Responder and Low-Responder rats.
Pharmacology, biochemistry, and behavior 2008;90(3):331-8.
2008: Turner Cortney A; Gula Edny L; Taylor Larry P; Watson Stanley J; Akil Huda
Antidepressant-like effects of intracerebroventricular FGF2 in rats.
Brain research 2008;1224():63-8.
2008: Day Heidi E W; Kryskow Elisa M; Watson Stanley J; Akil Huda; Campeau Serge
Regulation of hippocampal alpha1d adrenergic receptor mRNA by corticosterone in adrenalectomized rats.
Brain research 2008;1218():132-40.
2008: Jama A; Cecchi M; Calvo N; Watson S J; Akil H
Inter-individual differences in novelty-seeking behavior in rats predict differential responses to desipramine in the forced swim test.
Psychopharmacology 2008;198(3):333-40.
2008: Ballaz Santiago J; Akil Huda; Watson Stanley J
The CCK-system underpins novelty-seeking behavior in the rat: gene expression and pharmacological analyses.
Neuropeptides 2008;42(3):245-53.
2008: Sequeira A; Meng F; Rollins B; Myers R M; Jones E G; Watson S J; Akil H; Schatzberg A F; Barchas J; Bunney W E; Vawter M P
Coding SNPs included in exon arrays for the study of psychiatric disorders.
Molecular psychiatry 2008;13(4):363-5.
2008: McKinney B C; Schneider J S; Schafer G L; Lowing J L; Mohan S; Zhao M X; Heng M Y; Albin R L; Seasholtz A F; Akil H; Murphy G G
Decreased locomotor activity in mice expressing tTA under control of the CaMKII alpha promoter.
Genes, brain, and behavior 2008;7(2):203-13.
2008: Clinton Sarah; Miller Sue; Watson Stanley J; Akil Huda
Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity.
Psychoneuroendocrinology 2008;33(2):162-77.
2008: Turner Cortney A; Calvo Nelson; Frost Douglas O; Akil Huda; Watson Stanley J
The fibroblast growth factor system is downregulated following social defeat.
Neuroscience letters 2008;430(2):147-50.
2008: Flagel Shelly B; Watson Stanley J; Akil Huda; Robinson Terry E
Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization.
Behavioural brain research 2008;186(1):48-56.
2008: Akil H; Evans S J; Turner C A; Perez J; Myers R M; Bunney W E; Jones E G; Watson S J;
The fibroblast growth factor family and mood disorders.
Novartis Foundation symposium 2008;289():94-6; discussion 97-100, 193-5.
2008: Shao Ling; Martin Maureen V; Watson Stanley J; Schatzberg Alan; Akil Huda; Myers Richard M; Jones Edward G; Bunney William E; Vawter Marquis P
Mitochondrial involvement in psychiatric disorders.
Annals of medicine 2008;40(4):281-95.
2007: Hebda-Bauer E K; Luo J; Watson S J; Akil H
Female CREBalphadelta- deficient mice show earlier age-related cognitive deficits than males.
Neuroscience 2007;150(2):260-72.
2007: Kerman Ilan A; Bernard René; Rosenthal Devin; Beals James; Akil Huda; Watson Stanley J
Distinct populations of presympathetic-premotor neurons express orexin or melanin-concentrating hormone in the rat lateral hypothalamus.
The Journal of comparative neurology 2007;505(5):586-601.
2007: Karssen A M; Her S; Li J Z; Patel P D; Meng F; Bunney W E; Jones E G; Watson S J; Akil H; Myers R M; Schatzberg A F; Lyons D M
Stress-induced changes in primate prefrontal profiles of gene expression.
Molecular psychiatry 2007;12(12):1089-102.
2007: Langenecker Scott A; Kennedy Susan E; Guidotti Leslie M; Briceno Emily M; Own Lawrence S; Hooven Thomas; Young Elizabeth A; Akil Huda; Noll Douglas C; Zubieta Jon-Kar
Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder.
Biological psychiatry 2007;62(11):1272-80.
2007: Ballaz Santiago J; Akil Huda; Watson Stanley J
The CCK-system mediates adaptation to novelty-induced stress in the rat: a pharmacological evidence.
Neuroscience letters 2007;428(1):27-32.
2007: Langenecker Scott A; Zubieta Jon-Kar; Young Elizabeth A; Akil Huda; Nielson Kristy A
A task to manipulate attentional load, set-shifting, and inhibitory control: convergent validity and test-retest reliability of the Parametric Go/No-Go Test.
Journal of clinical and experimental neuropsychology 2007;29(8):842-53.
2007: Ballaz Santiago J; Akil Huda; Watson Stanley J
Previous experience affects subsequent anxiety-like responses in rats bred for novelty seeking.
Behavioral neuroscience 2007;121(5):1113-8.
2007: Ballaz S J; Akil H; Watson S J
The 5-HT7 receptor: role in novel object discrimination and relation to novelty-seeking behavior.
Neuroscience 2007;149(1):192-202.
2007: Wei Qiang; Hebda-Bauer Elaine K; Pletsch Amy; Luo Jie; Hoversten Mary T; Osetek Andrew J; Evans Simon J; Watson Stanley J; Seasholtz Audrey F; Akil Huda
Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(33):8836-44.
2007: Atz Mary; Walsh David; Cartagena Preston; Li Jun; Evans Simon; Choudary Prabhakara; Overman Kevin; Stein Richard; Tomita Hiro; Potkin Steven; Myers Rick; Watson Stanley J; Jones E G; Akil Huda; Bunney William E; Vawter Marquis P;
Methodological considerations for gene expression profiling of human brain.
Journal of neuroscience methods 2007;163(2):295-309.
2007: Ballaz S J; Akil H; Watson S J
Analysis of 5-HT6 and 5-HT7 receptor gene expression in rats showing differences in novelty-seeking behavior.
Neuroscience 2007;147(2):428-38.
2007: Buck Bradley J; Kerman Ilan A; Burghardt Paul R; Koch Lauren G; Britton Steven L; Akil Huda; Watson Stanley J
Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome.
Neuroscience letters 2007;419(2):178-83.
2007: Clinton Sarah M; Vázquez Delia M; Kabbaj Mohammed; Kabbaj Marie-Helen; Watson Stanley J; Akil Huda
Individual differences in novelty-seeking and emotional reactivity correlate with variation in maternal behavior.
Hormones and behavior 2007;51(5):655-64.
2007: Flagel Shelly B; Watson Stanley J; Robinson Terry E; Akil Huda
Individual differences in the propensity to approach signals vs goals promote different adaptations in the dopamine system of rats.
Psychopharmacology 2007;191(3):599-607.
2007: Rozeboom Aaron M; Akil Huda; Seasholtz Audrey F
Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4688-93.
2007: Cecchi Marco; Capriles Nancy; Watson Stanley J; Akil Huda
Beta1 adrenergic receptors in the bed nucleus of stria terminalis mediate differential responses to opiate withdrawal.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(3):589-99.
2007: Sliwerska Elzbieta; Meng Fan; Speed Terence P; Jones Edward G; Bunney William E; Akil Huda; Watson Stanley J; Burmeister Margit
SNPs on chips: the hidden genetic code in expression arrays.
Biological psychiatry 2007;61(1):13-6.
2007: Li Jun Z; Meng Fan; Tsavaler Larisa; Evans Simon J; Choudary Prabhakara V; Tomita Hiroaki; Vawter Marquis P; Walsh David; Shokoohi Vida; Chung Tisha; Bunney William E; Jones Edward G; Akil Huda; Watson Stanley J; Myers Richard M
Sample matching by inferred agonal stress in gene expression analyses of the brain.
BMC genomics 2007;8():336.
2006: Kerman Ilan A; Shabrang Cyrus; Taylor Larry; Akil Huda; Watson Stanley J
Relationship of presympathetic-premotor neurons to the serotonergic transmitter system in the rat brainstem.
The Journal of comparative neurology 2006;499(6):882-96.
2006: Stead John D H; Clinton Sarah; Neal Charles; Schneider Johanna; Jama Abas; Miller Sue; Vazquez Delia M; Watson Stanley J; Akil Huda
Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors.
Behavior genetics 2006;36(5):697-712.
2006: Vawter M P; Tomita H; Meng F; Bolstad B; Li J; Evans S; Choudary P; Atz M; Shao L; Neal C; Walsh D M; Burmeister M; Speed T; Myers R; Jones E G; Watson S J; Akil H; Bunney W E
Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders.
Molecular psychiatry 2006;11(7):615, 663-79.
2006: Turner Cortney A; Akil Huda; Watson Stanley J; Evans Simon J
The fibroblast growth factor system and mood disorders.
Biological psychiatry 2006;59(12):1128-35.
2006: Kerman Ilan A; Buck Bradley J; Evans Simon J; Akil Huda; Watson Stanley J
Combining laser capture microdissection with quantitative real-time PCR: effects of tissue manipulation on RNA quality and gene expression.
Journal of neuroscience methods 2006;153(1):71-85.
2006: Kerman Ilan A; Akil Huda; Watson Stanley J
Rostral elements of sympatho-motor circuitry: a virally mediated transsynaptic tracing study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(13):3423-33.
2006: Karssen Adriaan M; Li Jun Z; Her Song; Patel Paresh D; Meng Fan; Evans Simon J; Vawter Marquis P; Tomita Hiroaki; Choudary Prabhakara V; Bunney William E; Jones Edward G; Watson Stanley J; Akil Huda; Myers Richard M; Schatzberg Alan F; Lyons David M
Application of microarray technology in primate behavioral neuroscience research.
Methods (San Diego, Calif.) 2006;38(3):227-34.
2006: Stead John D H; Neal Charles; Meng Fan; Wang Yongjia; Evans Simon; Vazquez Delia M; Watson Stanley J; Akil Huda
Transcriptional profiling of the developing rat brain reveals that the most dramatic regional differentiation in gene expression occurs postpartum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(1):345-53.
2005: Choudary P V; Molnar M; Evans S J; Tomita H; Li J Z; Vawter M P; Myers R M; Bunney W E; Akil H; Watson S J; Jones E G
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(43):15653-8.
2005: Hebda-Bauer Elaine K; Watson Stanley J; Akil Huda
Cognitive performance is highly sensitive to prior experience in mice with a learning and memory deficit: failure leads to more failure.
Learning & memory (Cold Spring Harbor, N.Y.) 2005;12(5):461-71.
2005: Akil Huda
Stressed and depressed.
Nature medicine 2005;11(2):116-8.
2005: Dai Manhong; Wang Pinglang; Boyd Andrew D; Kostov Georgi; Athey Brian; Jones Edward G; Bunney William E; Myers Richard M; Speed Terry P; Akil Huda; Watson Stanley J; Meng Fan
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data.
Nucleic acids research 2005;33(20):e175.
2005: Helmreich Dana L; Parfitt D B; Lu X-Y; Akil H; Watson S J
Relation between the hypothalamic-pituitary-thyroid (HPT) axis and the hypothalamic-pituitary-adrenal (HPA) axis during repeated stress.
Neuroendocrinology 2005;81(3):183-92.
2005: Shieh Kun-Ruey; Yang Shu-Chuan; Lu Xin-Yun; Akil Huda; Watson Stanley J
Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain.
Journal of biomedical science 2005;12(1):209-17.
2004: Evans S J; Choudary P V; Neal C R; Li J Z; Vawter M P; Tomita H; Lopez J F; Thompson R C; Meng F; Stead J D; Walsh D M; Myers R M; Bunney W E; Watson S J; Jones E G; Akil H
Dysregulation of the fibroblast growth factor system in major depression.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15506-11.
2004: Wei Qiang; Lu Xin-Yun; Liu Li; Schafer Gwen; Shieh Kun-Ruey; Burke Sharon; Robinson Terry E; Watson Stanley J; Seasholtz Audrey F; Akil Huda
Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11851-6.
2004: Hebda-Bauer Elaine K; Watson Stanley J; Akil Huda
CREB deficient mice show inhibition and low activity in novel environments without changes in stress reactivity.
The European journal of neuroscience 2004;20(2):503-13.
2004: Li Jun Z; Vawter Marquis P; Walsh David M; Tomita Hiroaki; Evans Simon J; Choudary Prabhakara V; Lopez Juan F; Avelar Abigail; Shokoohi Vida; Chung Tisha; Mesarwi Omar; Jones Edward G; Watson Stanley J; Akil Huda; Bunney William E; Myers Richard M
Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions.
Human molecular genetics 2004;13(6):609-16.
2004: Tomita Hiroaki; Vawter Marquis P; Walsh David M; Evans Simon J; Choudary Prabhakara V; Li Jun; Overman Kevin M; Atz Mary E; Myers Richard M; Jones Edward G; Watson Stanley J; Akil Huda; Bunney William E
Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain.
Biological psychiatry 2004;55(4):346-52.
2004: López-Figueroa Antonio L; Norton Camille S; López-Figueroa Manuel O; Armellini-Dodel Denise; Burke Sharon; Akil Huda; López Juan F; Watson Stanley J
Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.
Biological psychiatry 2004;55(3):225-33.
2004: Vawter Marquis P; Evans Simon; Choudary Prabhakara; Tomita Hiroaki; Meador-Woodruff Jim; Molnar Margherita; Li Jun; Lopez Juan F; Myers Rick; Cox David; Watson Stanley J; Akil Huda; Jones Edward G; Bunney William E
Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(2):373-84.
2004: Kabbaj M; Evans S; Watson S J; Akil H
The search for the neurobiological basis of vulnerability to drug abuse: using microarrays to investigate the role of stress and individual differences.
Neuropharmacology 2004;47 Suppl 1():111-22.
2004: Isgor Ceylan; Kabbaj Mohamed; Akil Huda; Watson Stanley J
Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats.
Hippocampus 2004;14(5):636-48.
2004: Erb S; Funk D; Borkowski S; Watson S J; Akil H
Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis.
Neuroscience 2004;123(4):1003-9.
2003: Evans S J; Choudary P V; Vawter M P; Li J; Meador-Woodruff J H; Lopez J F; Burke S M; Thompson R C; Myers R M; Jones E G; Bunney W E; Watson S J; Akil H
DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles.
Neurobiology of disease 2003;14(2):240-50.
2003: Morgan Caurnel; Urbanski Henryk F; Fan Wei; Akil Huda; Cone Roger D
Pheromone-induced anorexia in male Syrian hamsters.
American journal of physiology. Endocrinology and metabolism 2003;285(5):E1028-38.
2003: McNally Gavan P; Akil Huda
Selective down-regulation of hippocampal glucocorticoid receptors during opiate withdrawal.
Brain research. Molecular brain research 2003;118(1-2):152-5.
2003: Morgan Caurnel; Thompson Robert C; Watson Stanley J; Akil Huda
Syrian hamster proopiomelanocortin cDNA cloning and early seasonal changes in testicular expression.
General and comparative endocrinology 2003;133(3):353-7.
2003: Lu Xin-Yun; Barsh Gregory S; Akil Huda; Watson Stanley J
Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(21):7863-72.
2003: Neal Charles R; Owens Constance E; Taylor Larry P; Hoversten Mary T; Akil Huda; Watson Stanley J
Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors.
Journal of chemical neuroanatomy 2003;25(4):233-47.
2003: Ferguson Susan M; Norton Camille S; Watson Stanley J; Akil Huda; Robinson Terry E
Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context.
Journal of neurochemistry 2003;86(1):33-44.
2003: Isgor Ceylan; Shieh Kun-Ruey; Akil Huda; Watson Stanley J
Colocalization of estrogen beta-receptor messenger RNA with orphanin FQ, vasopressin and oxytocin in the rat hypothalamic paraventricular and supraoptic nuclei.
Anatomy and embryology 2003;206(6):461-9.
2003: Gordon Nakia S; Burke Sharon; Akil Huda; Watson Stanley J; Panksepp Jaak
Socially-induced brain 'fertilization': play promotes brain derived neurotrophic factor transcription in the amygdala and dorsolateral frontal cortex in juvenile rats.
Neuroscience letters 2003;341(1):17-20.
2003: Bunney William E; Bunney Blynn G; Vawter Marquis P; Tomita Hiroaki; Li Jun; Evans Simon J; Choudary Prabhakara V; Myers Richard M; Jones Edward G; Watson Stanley J; Akil Huda
Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders.
The American journal of psychiatry 2003;160(4):657-66.
2003: Uslaner Jason M; Norton Camille S; Watson Stanley J; Akil Huda; Robinson Terry E
Amphetamine-induced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between dose, environment, and neuronal phenotype.
Journal of neurochemistry 2003;85(1):105-14.
2003: Devine D P; Hoversten M T; Ueda Y; Akil H
Nociceptin/orphanin FQ content is decreased in forebrain neurones during acute stress.
Journal of neuroendocrinology 2003;15(1):69-74.
2003: Young Elizabeth A; Lopez Juan F; Murphy-Weinberg Virginia; Watson Stanley J; Akil Huda
Mineralocorticoid receptor function in major depression.
Archives of general psychiatry 2003;60(1):24-8.
2003: Isgor C; Cecchi M; Kabbaj M; Akil H; Watson S J
Estrogen receptor beta in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone.
Neuroscience 2003;121(4):837-45.
2003: Ostrander M M; Badiani A; Day H E W; Norton C S; Watson S J; Akil H; Robinson T E
Environmental context and drug history modulate amphetamine-induced c-fos mRNA expression in the basal ganglia, central extended amygdala, and associated limbic forebrain.
Neuroscience 2003;120(2):551-71.
2002: Isgor Ceylan; Huang Grace C; Akil Huda; Watson Stanley J
Correlation of estrogen beta-receptor messenger RNA with endogenous levels of plasma estradiol and progesterone in the female rat hypothalamus, the bed nucleus of stria terminalis and the medial amygdala.
Brain research. Molecular brain research 2002;106(1-2):30-41.
2002: Lu Xin-Yun; Shieh Kun-Ruey; Kabbaj Mohamed; Barsh Gregory S; Akil Huda; Watson Stanley J
Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake.
Endocrinology 2002;143(10):3905-15.
2002: Evans Simon J; Datson Nicole A; Kabbaj Mohamed; Thompson Robert C; Vreugdenhil Erno; De Kloet E Ronald; Watson Stanley J; Akil Huda
Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression.
The European journal of neuroscience 2002;16(3):409-13.
2002: Day Heidi E W; Vittoz Nicole M; Oates Matthew M; Badiani Aldo; Watson Stanley J; Robinson Terry E; Akil Huda
A 6-hydroxydopamine lesion of the mesostriatal dopamine system decreases the expression of corticotropin releasing hormone and neurotensin mRNAs in the amygdala and bed nucleus of the stria terminalis.
Brain research 2002;945(2):151-9.
2002: Campeau Serge; Dolan David; Akil Huda; Watson Stanley J
c-fos mRNA induction in acute and chronic audiogenic stress: possible role of the orbitofrontal cortex in habituation.
Stress (Amsterdam, Netherlands) 2002;5(2):121-30.
2002: Gordon Nakia S; Kollack-Walker Sara; Akil Huda; Panksepp Jaak
Expression of c-fos gene activation during rough and tumble play in juvenile rats.
Brain research bulletin 2002;57(5):651-9.
2002: Norton Camille S; Neal Charles R; Kumar Suneel; Akil Huda; Watson Stanley J
Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems.
The Journal of comparative neurology 2002;444(4):358-68.
2002: Klebaur Jennifer E; Ostrander Michelle M; Norton Camille S; Watson Stanley J; Akil Huda; Robinson Terry E
The ability of amphetamine to evoke arc (Arg 3.1) mRNA expression in the caudate, nucleus accumbens and neocortex is modulated by environmental context.
Brain research 2002;930(1-2):30-6.
2002: Owens Constance E; Akil Huda
Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor.
The Journal of pharmacology and experimental therapeutics 2002;300(3):992-9.
2002: Nicholson J R; Akil H; Watson S J
Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors.
Neuroscience 2002;115(2):637-43.
2002: Kabbaj M; Isgor C; Watson S J; Akil H
Stress during adolescence alters behavioral sensitization to amphetamine.
Neuroscience 2002;113(2):395-400.
2002: López-Figueroa Manuel O; Caamaño Claudio A; Morano M Inés; Akil Huda; Watson Stanley J
Fluorescent imaging of mitochondrial nitric oxide in living cells.
Methods in enzymology 2002;352():296-303.
2002: McNally G P; Akil H
Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal.
Neuroscience 2002;112(3):605-17.
2001: Kabbaj M; Norton C S; Kollack-Walker S; Watson S J; Robinson T E; Akil H
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior.
Psychopharmacology 2001;158(4):382-7.
2001: Neal C R; Akil H; Watson S J
Expression of orphanin FQ and the opioid receptor-like (ORL1) receptor in the developing human and rat brain.
Journal of chemical neuroanatomy 2001;22(4):219-49.
2001: Uslaner J; Badiani A; Day H E; Watson S J; Akil H; Robinson T E
Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens.
Brain research 2001;920(1-2):106-16.
2001: López-Figueroa M O; Caamaño C; Marin R; Guerra B; Alonso R; Morano M I; Akil H; Watson S J
Characterization of basal nitric oxide production in living cells.
Biochimica et biophysica acta 2001;1540(3):253-64.
2001: McNally G P; Akil H
Effects of contextual or olfactory cues previously paired with morphine withdrawal on behavior and pain sensitivity in the rat.
Psychopharmacology 2001;156(4):381-7.
2001: Danielson P B; Hoversten M T; Fitzpatrick M; Schreck C; Akil H; Dores R M
Sturgeon orphanin, a molecular "fossil" that bridges the gap between the opioids and orphanin FQ/nociceptin.
The Journal of biological chemistry 2001;276(25):22114-9.
2001: Uslaner J; Badiani A; Norton C S; Day H E; Watson S J; Akil H; Robinson T E
Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context.
The European journal of neuroscience 2001;13(10):1977-83.
2001: Lu X Y; Nicholson J R; Akil H; Watson S J
Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132).
Neuroreport 2001;12(6):1281-4.
2001: Helmreich D L; Itoi K; Lopez-Figueroa M O; Akil H; Watson S J
Norepinephrine-induced CRH and AVP gene transcription within the hypothalamus: differential regulation by corticosterone.
Brain research. Molecular brain research 2001;88(1-2):62-73.
2001: Day H E; Badiani A; Uslaner J M; Oates M M; Vittoz N M; Robinson T E; Watson S J; Akil H
Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(2):732-40.
2001: Caamaño C A; Morano M I; Akil H
Corticosteroid receptors: a dynamic interplay between protein folding and homeostatic control. Possible implications in psychiatric disorders.
Psychopharmacology bulletin 2001;35(1):6-23.
2001: Kabbaj M; Akil H
Individual differences in novelty-seeking behavior in rats: a c-fos study.
Neuroscience 2001;106(3):535-45.
2001: Devine D P; Watson S J; Akil H
Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis.
Neuroscience 2001;102(3):541-53.
2000: Watson S J; Meng F; Thompson R C; Akil H
The "chip" as a specific genetic tool.
Biological psychiatry 2000;48(12):1147-56.
2000: Young E A; Lopez J F; Murphy-Weinberg V; Watson S J; Akil H
Hormonal evidence for altered responsiveness to social stress in major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;23(4):411-8.
2000: Kabbaj M; Devine D P; Savage V R; Akil H
Neurobiological correlates of individual differences in novelty-seeking behavior in the rat: differential expression of stress-related molecules.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):6983-8.
2000: Bonner G; Meng F; Akil H
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
European journal of pharmacology 2000;403(1-2):37-44.
2000: Lee S P; O'Dowd B F; Ng G Y; Varghese G; Akil H; Mansour A; Nguyen T; George S R
Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell.
Molecular pharmacology 2000;58(1):120-8.
2000: Meng F; Wei Q; Hoversten M T; Taylor L P; Akil H
Switching agonist/antagonist properties of opiate alkaloids at the delta opioid receptor using mutations based on the structure of the orphanin FQ receptor.
The Journal of biological chemistry 2000;275(29):21939-45.
2000: Lu X Y; Bagnol D; Burke S; Akil H; Watson S J
Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting.
Hormones and behavior 2000;37(4):335-44.
2000: López-Figueroa M O; Caamaño C; Morano M I; Rønn L C; Akil H; Watson S J
Direct evidence of nitric oxide presence within mitochondria.
Biochemical and biophysical research communications 2000;272(1):129-33.
2000: López-Figueroa M O; Day H E; Lee S; Rivier C; Akil H; Watson S J
Temporal and anatomical distribution of nitric oxide synthase mRNA expression and nitric oxide production during central nervous system inflammation.
Brain research 2000;852(1):239-46.
2000: Akil H; Watson S J
Science and the future of psychiatry.
Archives of general psychiatry 2000;57(1):86-7.
1999: López J F; Akil H; Watson S J
Neural circuits mediating stress.
Biological psychiatry 1999;46(11):1461-71.
1999: Lu X y; Gunn T M; Shieh K r; Barsh G S; Akil H; Watson S J
Distribution of Mahogany/Attractin mRNA in the rat central nervous system.
FEBS letters 1999;462(1-2):101-7.
1999: Day H E; Campeau S; Watson S J; Akil H
Expression of alpha(1b) adrenoceptor mRNA in corticotropin-releasing hormone-containing cells of the rat hypothalamus and its regulation by corticosterone.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(22):10098-106.
1999: Neilan C L; Akil H; Woods J H; Traynor J R
Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists.
British journal of pharmacology 1999;128(3):556-62.
1999: Day H E; Curran E J; Watson S J; Akil H
Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: evidence for their selective activation by interleukin-1beta.
The Journal of comparative neurology 1999;413(1):113-28.
1999: Neal C R; Mansour A; Reinscheid R; Nothacker H P; Civelli O; Akil H; Watson S J
Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding.
The Journal of comparative neurology 1999;412(4):563-605.
1999: Badiani A; Oates M M; Day H E; Watson S J; Akil H; Robinson T E
Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons.
Behavioural brain research 1999;103(2):203-9.
1999: Bagnol D; Lu X Y; Kaelin C B; Day H E; Ollmann M; Gantz I; Akil H; Barsh G S; Watson S J
Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(18):RC26.
1999: Lee K O; Akil H; Woods J H; Traynor J R
Differential binding properties of oripavines at cloned mu- and delta-opioid receptors.
European journal of pharmacology 1999;378(3):323-30.
1999: Day H E; Akil H
Evidence that cholecystokinin receptors are not involved in the hypothalamic-pituitary-adrenal response to intraperitoneal administration of interleukin-1beta.
Journal of neuroendocrinology 1999;11(7):561-8.
1999: Kollack-Walker S; Don C; Watson S J; Akil H
Differential expression of c-fos mRNA within neurocircuits of male hamsters exposed to acute or chronic defeat.
Journal of neuroendocrinology 1999;11(7):547-59.
1999: Watson S J; Akil H
Gene chips and arrays revealed: a primer on their power and their uses.
Biological psychiatry 1999;45(5):533-43.
1999: Helmreich D L; Watkins L R; Deak T; Maier S F; Akil H; Watson S J
The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus.
Journal of neuroendocrinology 1999;11(2):121-8.
1999: Remmers A E; Clark M J; Mansour A; Akil H; Woods J H; Medzihradsky F
Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor.
The Journal of pharmacology and experimental therapeutics 1999;288(2):827-33.
1998: Badiani A; Oates M M; Day H E; Watson S J; Akil H; Robinson T E
Amphetamine-induced behavior, dopamine release, and c-fos mRNA expression: modulation by environmental novelty.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(24):10579-93.
1998: López-Figueroa M O; Day H E; Akil H; Watson S J
Nitric oxide in the stress axis.
Histology and histopathology 1998;13(4):1243-52.
1998: Young E A; Lopez J F; Murphy-Weinberg V; Watson S J; Akil H
The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans.
The Journal of clinical endocrinology and metabolism 1998;83(9):3339-45.
1998: Caamaño C A; Morano M I; Dalman F C; Pratt W B; Akil H
A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling.
The Journal of biological chemistry 1998;273(32):20473-80.
1998: Alt A; Mansour A; Akil H; Medzihradsky F; Traynor J R; Woods J H
Stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding by endogenous opioids acting at a cloned mu receptor.
The Journal of pharmacology and experimental therapeutics 1998;286(1):282-8.
1998: Vázquez D M; López J F; Morano M I; Kwak S P; Watson S J; Akil H
Alpha, beta, and gamma mineralocorticoid receptor messenger ribonucleic acid splice variants: differential expression and rapid regulation in the developing hippocampus.
Endocrinology 1998;139(7):3165-77.
1998: Akil H; Owens C; Gutstein H; Taylor L; Curran E; Watson S
Endogenous opioids: overview and current issues.
Drug and alcohol dependence 1998;51(1-2):127-40.
1998: Gutstein H B; Mansour A; Watson S J; Akil H; Fields H L
Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla.
Neuroreport 1998;9(8):1777-81.
1998: Meng F; Ueda Y; Hoversten M T; Taylor L P; Reinscheid R K; Monsma F J; Watson S J; Civelli O; Akil H
Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis.
Molecular pharmacology 1998;53(4):772-7.
1998: Gutstein H B; Thome J L; Fine J L; Watson S J; Akil H
Pattern of c-fos mRNA induction in rat brain by acute morphine.
Canadian journal of physiology and pharmacology 1998;76(3):294-303.
1998: Coward P; Wada H G; Falk M S; Chan S D; Meng F; Akil H; Conklin B R
Controlling signaling with a specifically designed Gi-coupled receptor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):352-7.
1997: Liberzon I; Trujillo K A; Akil H; Young E A
Motivational properties of oxytocin in the conditioned place preference paradigm.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;17(6):353-9.
1997: Emmerson P J; Archer S; El-Hamouly W; Mansour A; Akil H; Medzihradsky F
Synthesis and characterization of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-labeled fluorescent ligands for the mu opioid receptor.
Biochemical pharmacology 1997;54(12):1315-22.
1997: Gutstein H B; Rubie E A; Mansour A; Akil H; Woodgett J R
Opioid effects on mitogen-activated protein kinase signaling cascades.
Anesthesiology 1997;87(5):1118-26.
1997: Clark M J; Emmerson P J; Mansour A; Akil H; Woods J H; Portoghese P S; Remmers A E; Medzihradsky F
Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor.
The Journal of pharmacology and experimental therapeutics 1997;283(2):501-10.
1997: Kollack-Walker S; Watson S J; Akil H
Social stress in hamsters: defeat activates specific neurocircuits within the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(22):8842-55.
1997: Bagnol D; Mansour A; Akil H; Watson S J
Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract.
Neuroscience 1997;81(2):579-91.
1997: Campeau S; Akil H; Watson S J
Lesions of the medial geniculate nuclei specifically block corticosterone release and induction of c-fos mRNA in the forebrain associated with audiogenic stress in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(15):5979-92.
1997: Vázquez D M; Morano M I; Taylor L; Akil H
Kinetics of radiolabeled adrenocorticotropin hormone in infant and weanling rats.
Journal of neuroendocrinology 1997;9(7):529-36.
1997: Day H E; Campeau S; Watson S J; Akil H
Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord.
Journal of chemical neuroanatomy 1997;13(2):115-39.
1997: Ruzicka B B; Akil H
The interleukin-1beta-mediated regulation of proenkephalin and opioid receptor messenger RNA in primary astrocyte-enriched cultures.
Neuroscience 1997;79(2):517-24.
1997: Fickel J; Bagnol D; Watson S J; Akil H
Opioid receptor expression in the rat gastrointestinal tract: a quantitative study with comparison to the brain.
Brain research. Molecular brain research 1997;46(1-2):1-8.
1997: Young E A; Lopez J F; Murphy-Weinberg V; Watson S J; Akil H
Normal pituitary response to metyrapone in the morning in depressed patients: implications for circadian regulation of corticotropin-releasing hormone secretion.
Biological psychiatry 1997;41(12):1149-55.
1997: Mansour A; Taylor L P; Fine J L; Thompson R C; Hoversten M T; Mosberg H I; Watson S J; Akil H
Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study.
Journal of neurochemistry 1997;68(1):344-53.
1996: Meng F; Taylor L P; Hoversten M T; Ueda Y; Ardati A; Reinscheid R K; Monsma F J; Watson S J; Civelli O; Akil H
Moving from the orphanin FQ receptor to an opioid receptor using four point mutations.
The Journal of biological chemistry 1996;271(50):32016-20.
1996: Curran E J; Akil H; Watson S J
Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitized animals.
Neurochemical research 1996;21(11):1425-35.
1996: Devine D P; Taylor L; Reinscheid R K; Monsma F J; Civelli O; Akil H
Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ.
Neurochemical research 1996;21(11):1387-96.
1996: Akil H
Special issue dedicated to Dr. Eric J. Simon.
Neurochemical research 1996;21(11):1271-5.
1996: Cho W; Taylor L P; Akil H
Mutagenesis of residues adjacent to transmembrane prolines alters D1 dopamine receptor binding and signal transduction.
Molecular pharmacology 1996;50(5):1338-45.
1996: Meng F; Ueda Y; Hoversten M T; Thompson R C; Taylor L; Watson S J; Akil H
Mapping the receptor domains critical for the binding selectivity of delta-opioid receptor ligands.
European journal of pharmacology 1996;311(2-3):285-92.
1996: Emmerson P J; Clark M J; Mansour A; Akil H; Woods J H; Medzihradsky F
Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1121-7.
1996: Vázquez D M; Van Oers H; Levine S; Akil H
Regulation of glucocorticoid and mineralocorticoid receptor mRNAs in the hippocampus of the maternally deprived infant rat.
Brain research 1996;731(1-2):79-90.
1996: Devine D P; Reinscheid R K; Monsma F J; Civelli O; Akil H
The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion.
Brain research 1996;727(1-2):225-9.
1996: Mansour A; Burke S; Pavlic R J; Akil H; Watson S J
Immunohistochemical localization of the cloned kappa 1 receptor in the rat CNS and pituitary.
Neuroscience 1996;71(3):671-90.
1996: Day H E; Akil H
Differential pattern of c-fos mRNA in rat brain following central and systemic administration of interleukin-1-beta: implications for mechanism of action.
Neuroendocrinology 1996;63(3):207-18.
1996: Watson B; Meng F; Akil H
A chimeric analysis of the opioid receptor domains critical for the binding selectivity of mu opioid ligands.
Neurobiology of disease 1996;3(1):87-96.
1996: Ruzicka B B; Thompson R C; Watson S J; Akil H
Interleukin-1 beta-mediated regulation of mu-opioid receptor mRNA in primary astrocyte-enriched cultures.
Journal of neurochemistry 1996;66(1):425-8.
1996: Cucumel K; Garreau I; Mery J; Moinier D; Mansour A; Akil H; Cupo A
Production and characterization of site-directed antibodies against dermorphin and dermorphin-related peptides.
Peptides 1996;17(6):973-82.
1996: Akil H; Meng F; Mansour A; Thompson R; Xie G X; Watson S
Cloning and characterization of multiple opioid receptors.
NIDA research monograph 1996;161():127-40.
1995: Ruzicka B B; Fox C A; Thompson R C; Meng F; Watson S J; Akil H
Primary astroglial cultures derived from several rat brain regions differentially express mu, delta and kappa opioid receptor mRNA.
Brain research. Molecular brain research 1995;34(2):209-20.
1995: Mansour A; Hoversten M T; Taylor L P; Watson S J; Akil H
The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores.
Brain research 1995;700(1-2):89-98.
1995: Trujillo K A; Bronstein D M; Sanchez I O; Akil H
Effects of chronic opiate and opioid antagonist treatment on striatal opioid peptides.
Brain research 1995;698(1-2):69-78.
1995: Cho W; Taylor L P; Mansour A; Akil H
Hydrophobic residues of the D2 dopamine receptor are important for binding and signal transduction.
Journal of neurochemistry 1995;65(5):2105-15.
1995: Caamaño C A; Morano M I; Dalman F C; Hoversten M T; Watson S J; Pratt W B; Akil H
Point mutations in the 90-kDa heat shock protein binding region of the glucocorticoid receptor affect the functional characteristics of the receptor.
Annals of the New York Academy of Sciences 1995;761():403-4.
1995: Herman J P; Cullinan W E; Morano M I; Akil H; Watson S J
Contribution of the ventral subiculum to inhibitory regulation of the hypothalamo-pituitary-adrenocortical axis.
Journal of neuroendocrinology 1995;7(6):475-82.
1995: Meng F; Hoversten M T; Thompson R C; Taylor L; Watson S J; Akil H
A chimeric study of the molecular basis of affinity and selectivity of the kappa and the delta opioid receptors. Potential role of extracellular domains.
The Journal of biological chemistry 1995;270(21):12730-6.
1995: Trujillo K A; Akil H
Excitatory amino acids and drugs of abuse: a role for N-methyl-D-aspartate receptors in drug tolerance, sensitization and physical dependence.
Drug and alcohol dependence 1995;38(2):139-54.
1995: Mansour A; Fox C A; Burke S; Akil H; Watson S J
Immunohistochemical localization of the cloned mu opioid receptor in the rat CNS.
Journal of chemical neuroanatomy 1995;8(4):283-305.
1995: Gutstein H B; Trujillo K A; Akil H
Does chronic nociceptive stimulation alter the development of morphine tolerance?
Brain research 1995;680(1-2):173-9.
1995: Young E A; Akil H; Haskett R F; Watson S J
Evidence against changes in corticotroph CRF receptors in depressed patients.
Biological psychiatry 1995;37(6):355-63.
1995: Badiani A; Morano M I; Akil H; Robinson T E
Circulating adrenal hormones are not necessary for the development of sensitization to the psychomotor activating effects of amphetamine.
Brain research 1995;673(1):13-24.
1995: Ruzicka B B; Akil H
Differential cellular regulation of pro-opiomelanocortin by interleukin-1-beta and corticotropin-releasing hormone.
Neuroendocrinology 1995;61(2):136-51.
1995: Mansour A; Watson S J; Akil H
Opioid receptors: past, present and future.
Trends in neurosciences 1995;18(2):69-70.
1995: Cullinan W E; Herman J P; Battaglia D F; Akil H; Watson S J
Pattern and time course of immediate early gene expression in rat brain following acute stress.
Neuroscience 1995;64(2):477-505.
1995: Mansour A; Fox C A; Akil H; Watson S J
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications.
Trends in neurosciences 1995;18(1):22-9.
1994: Mansour A; Fox C A; Burke S; Meng F; Thompson R C; Akil H; Watson S J
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study.
The Journal of comparative neurology 1994;350(3):412-38.
1994: Caamaño C A; Morano M I; Watson S J; Dalman F C; Pratt W B; Akil H
The functional relevance of the heteromeric structure of corticosteroid receptors.
Annals of the New York Academy of Sciences 1994;746():68-77; discussion 77-8, 131-3.
1994: Meng F; Xie G X; Chalmers D; Morgan C; Watson S J; Akil H
Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain.
Brain research. Molecular brain research 1994;26(1-2):143-55.
1994: Morano M I; Vázquez D M; Akil H
The role of the hippocampal mineralocorticoid and glucocorticoid receptors in the hypothalamo-pituitary-adrenal axis of the aged Fisher rat.
Molecular and cellular neurosciences 1994;5(5):400-12.
1994: Young E A; Haskett R F; Grunhaus L; Pande A; Weinberg V M; Watson S J; Akil H
Increased evening activation of the hypothalamic-pituitary-adrenal axis in depressed patients.
Archives of general psychiatry 1994;51(9):701-7.
1994: Meng F; Xie G X; Chalmers D; Morgan C; Watson S J; Akil H
Cloning and expression of the A2a adenosine receptor from guinea pig brain.
Neurochemical research 1994;19(5):613-21.
1994: Chalmers D T; López J F; Vázquez D M; Akil H; Watson S J
Regulation of hippocampal 5-HT1A receptor gene expression by dexamethasone.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994;10(3):215-22.
1994: Xie G X; Meng F; Mansour A; Thompson R C; Hoversten M T; Goldstein A; Watson S J; Akil H
Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3779-83.
1994: Mansour A; Fox C A; Thompson R C; Akil H; Watson S J
mu-Opioid receptor mRNA expression in the rat CNS: comparison to mu-receptor binding.
Brain research 1994;643(1-2):245-65.
1994: Mansour A; Fox C A; Meng F; Akil H; Watson S J
Kappa 1 receptor mRNA distribution in the rat CNS: comparison to kappa receptor binding and prodynorphin mRNA.
Molecular and cellular neurosciences 1994;5(2):124-44.
1994: López J F; Chalmers D T; Vázquez D M; Watson S J; Akil H
Serotonin transporter mRNA in rat brain is regulated by classical antidepressants.
Biological psychiatry 1994;35(4):287-90.
1994: Dupuy A; Lindberg I; Zhou Y; Akil H; Lazure C; Chrétien M; Seidah N G; Day R
Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue.
FEBS letters 1994;337(1):60-5.
1994: Trujillo K A; Akil H
Inhibition of opiate tolerance by non-competitive N-methyl-D-aspartate receptor antagonists.
Brain research 1994;633(1-2):178-88.
1994: Akil H; Watson S J
Cloning of kappa opioid receptors: functional significance and future directions.
Progress in brain research 1994;100():81-6.
1993: Day R; Schäfer M K; Collard M W; Weihe E; Akil H
Prodynorphin gene expression in the rat intermediate pituitary lobe: gender differences and postpartum regulation.
Endocrinology 1993;133(6):2652-9.
1993: Kwak S P; Patel P D; Thompson R C; Akil H; Watson S J
5'-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus.
Endocrinology 1993;133(5):2344-50.
1993: Thompson R C; Mansour A; Akil H; Watson S J
Cloning and pharmacological characterization of a rat mu opioid receptor.
Neuron 1993;11(5):903-13.
1993: Meng F; Xie G X; Thompson R C; Mansour A; Goldstein A; Watson S J; Akil H
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9954-8.
1993: Mansour A; Thompson R C; Akil H; Watson S J
Delta opioid receptor mRNA distribution in the brain: comparison to delta receptor binding and proenkephalin mRNA.
Journal of chemical neuroanatomy 1993;6(6):351-62.
1993: Vázquez D M; Morano M I; López J F; Watson S J; Akil H
Short-term adrenalectomy increases glucocorticoid and mineralocorticoid receptor mRNA in selective areas of the developing hippocampus.
Molecular and cellular neurosciences 1993;4(5):455-71.
1993: Young E A; Bronstein D; Akil H
Dopamine regulation of swim stress induction of the pituitary intermediate lobe proopiomelanocortin system.
Neuroendocrinology 1993;58(3):294-302.
1993: Caamaño C A; Morano M I; Patel P D; Watson S J; Akil H
A bacterially expressed mineralocorticoid receptor is associated in vitro with the 90-kilodalton heat shock protein and shows typical hormone- and DNA-binding characteristics.
Biochemistry 1993;32(33):8589-95.
1993: Lin H L; Day N C; Ueda Y; Martin D K; Dixon J E; Seidah N G; Akil H
Tissue-specific and substrate-specific endoproteolytic cleavage of monkey pro-opiomelanocortin in heterologous endocrine cells: processing at Lys-Lys dibasic pairs.
Neuroendocrinology 1993;58(1):94-105.
1993: Bronstein D M; Gutstein H B; Akil H
Effects of chronic morphine treatment on beta-endorphin-related peptides in the caudal medulla and spinal cord.
Journal of neurochemistry 1993;60(6):2304-7.
1993: Young E A; Kotun J; Haskett R F; Grunhaus L; Greden J F; Watson S J; Akil H
Dissociation between pituitary and adrenal suppression to dexamethasone in depression.
Archives of general psychiatry 1993;50(5):395-403.
1993: Day N C; Lin H; Ueda Y; Meador-Woodruff J H; Akil H
Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA.
Neuropeptides 1993;24(5):253-62.
1993: Chalmers D T; Kwak S P; Mansour A; Akil H; Watson S J
Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(3):914-23.
1993: Young E A; Przewlocki R; Patel P; Watson S J; Akil H
Altered ratios of beta-endorphin: beta-lipotropin released from anterior lobe corticotropes with increased secretory drive. I. Effects of diminished glucocorticoid secretion.
Journal of neuroendocrinology 1993;5(1):115-20.
1993: Young E A; Day R; Schafer M; Watson S J; Akil H
Altered ratios of beta-endorphin:beta-lipotropin released from anterior lobe corticotropes with increased secretory drive. II. Repeated stress.
Journal of neuroendocrinology 1993;5(1):121-6.
1993: Bronstein D M; Day N C; Gutstein H B; Trujillo K A; Akil H
Pre- and posttranslational regulation of beta-endorphin biosynthesis in the CNS: effects of chronic naltrexone treatment.
Journal of neurochemistry 1993;60(1):40-9.
1993: Kwak S P; Morano M I; Young E A; Watson S J; Akil H
Diurnal CRH mRNA rhythm in the hypothalamus: decreased expression in the evening is not dependent on endogenous glucocorticoids.
Neuroendocrinology 1993;57(1):96-105.
1993: Akil H; Haskett R F; Young E A; Grunhaus L; Kotun J; Weinberg V; Greden J; Watson S J
Multiple HPA profiles in endogenous depression: effect of age and sex on cortisol and beta-endorphin.
Biological psychiatry 1993;33(2):73-85.
1992: Gutstein H B; Bronstein D M; Akil H
Beta-endorphin processing and cellular origins in rat spinal cord.
Pain 1992;51(2):241-7.
1992: Mansour A; Meng F; Meador-Woodruff J H; Taylor L P; Civelli O; Akil H
Site-directed mutagenesis of the human dopamine D2 receptor.
European journal of pharmacology 1992;227(2):205-14.
1992: López J F; Palkovits M; Arató M; Mansour A; Akil H; Watson S J
Localization and quantification of pro-opiomelanocortin mRNA and glucocorticoid receptor mRNA in pituitaries of suicide victims.
Neuroendocrinology 1992;56(4):491-501.
1992: Herman J P; Cullinan W E; Young E A; Akil H; Watson S J
Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression.
Brain research 1992;592(1-2):228-38.
1992: Vázquez D M; Akil H
Development of pituitary pro-opiomelanocortin gene and peptide expression: characterization and effect of repeated intermittent maternal isolation.
Neuroendocrinology 1992;56(3):320-30.
1992: Bronstein D M; Schafer M K; Watson S J; Akil H
Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA.
Brain research 1992;587(2):269-75.
1992: Kwak S P; Young E A; Morano I; Watson S J; Akil H
Diurnal corticotropin-releasing hormone mRNA variation in the hypothalamus exhibits a rhythm distinct from that of plasma corticosterone.
Neuroendocrinology 1992;55(1):74-83.
1992: Mansour A; Meador-Woodruff J H; Zhou Q; Civelli O; Akil H; Watson S J
A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques.
Neuroscience 1992;46(4):959-71.
1991: Meador-Woodruff J H; Mansour A; Healy D J; Kuehn R; Zhou Q Y; Bunzow J R; Akil H; Civelli O; Watson S J
Comparison of the distributions of D1 and D2 dopamine receptor mRNAs in rat brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1991;5(4):231-42.
1991: Trujillo K A; Akil H
Opiate tolerance and dependence: recent findings and synthesis.
The New biologist 1991;3(10):915-23.
1991: Young E A; Haskett R F; Murphy-Weinberg V; Watson S J; Akil H
Loss of glucocorticoid fast feedback in depression.
Archives of general psychiatry 1991;48(8):693-9.
1991: Young E A; Grunhaus L; Haskett R F; Pande A C; Murphy-Weinberg V; Akil H; Watson S J
Heterogeneity in the beta-endorphin immunoreactivity response to electroconvulsive therapy.
Archives of general psychiatry 1991;48(6):534-9.
1991: Trujillo K A; Akil H
The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality.
Pharmacology, biochemistry, and behavior 1991;38(3):673-5.
1991: Day R; Schafer M K; Collard M W; Watson S J; Akil H
Atypical prodynorphin gene expression in corticosteroid-producing cells of the rat adrenal gland.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1320-4.
1991: Dalman F C; Scherrer L C; Taylor L P; Akil H; Pratt W B
Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition.
The Journal of biological chemistry 1991;266(6):3482-90.
1991: Trujillo K A; Akil H
Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801.
Science (New York, N.Y.) 1991;251(4989):85-7.
1991: Nemeroff C B; Bissette G; Akil H; Fink M
Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotrophin-releasing factor, beta-endorphin and somatostatin.
The British journal of psychiatry : the journal of mental science 1991;158():59-63.
1991: Cullinan W E; Day N C; Schäfer M K; Day R; Seidah N G; Chrétien M; Akil H; Watson S J
Neuroanatomical and functional studies of peptide precursor-processing enzymes.
Enzyme 1991;45(5-6):285-300.
1991: Bronstein D M; Kelsey J E; Akil H
Regulation of beta-endorphin biosynthesis in the brain: different effects of morphine pelleting and repeated stress.
NIDA research monograph 1991;111():113-32.
1991: Mansour A; Meador-Woodruff J H; Zhou Q Y; Civelli O; Akil H; Watson S J
A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques.
Neuroscience 1991;45(2):359-71.
1990: Collard M W; Day R; Akil H; Uhler M D; Douglass J O
Sertoli cells are the primary site of prodynorphin gene expression in rat testis: regulation of mRNA and secreted peptide levels by cyclic adenosine 3' ,5'-monophosphate analogs in cultured cells.
Molecular endocrinology (Baltimore, Md.) 1990;4(10):1488-96.
1990: Mansour A; Meador-Woodruff J H; Bunzow J R; Civelli O; Akil H; Watson S J
Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(8):2587-600.
1990: Bronstein D M; Przewlocki R; Akil H
Effects of morphine treatment on pro-opiomelanocortin systems in rat brain.
Brain research 1990;519(1-2):102-11.
1990: Trujillo K A; Day R; Akil H
Regulation of striatonigral prodynorphin peptides by dopaminergic agents.
Brain research 1990;518(1-2):244-56.
1990: Bronstein D M; Akil H
In vitro release of hypothalamic beta-endorphin (beta E) by arginine vasopressin, corticotropin-releasing hormone and 5-hydroxytryptamine: evidence for release of opioid active and inactive beta E forms.
Neuropeptides 1990;16(1):33-40.
1990: Young E A; Watson S J; Kotun J; Haskett R F; Grunhaus L; Murphy-Weinberg V; Vale W; Rivier J; Akil H
Beta-lipotropin-beta-endorphin response to low-dose ovine corticotropin releasing factor in endogenous depression. Preliminary studies.
Archives of general psychiatry 1990;47(5):449-57.
1990: Schäfer M K; Day R; Ortega M R; Akil H; Watson S J
Proenkephalin messenger RNA is expressed both in the rat anterior and posterior pituitary.
Neuroendocrinology 1990;51(4):444-8.
1990: Meador-Woodruff J H; Pellerito B; Bronstein D; Lin H L; Ling N; Akil H
Differential effects of haloperidol on the rat pituitary: decreased biosynthesis, processing and release of anterior lobe pro-opiomelanocortin.
Neuroendocrinology 1990;51(3):294-303.
1990: Schafer M K; Day R; Akil H; Watson S J
Identification of prodynorphin and proenkephalin mRNA expressing cells in the neurointermediate lobe of the rat pituitary gland.
Progress in clinical and biological research 1990;328():231-4.
1990: Trujillo K A; Akil H
Pharmacological regulation of striatal prodynorphin peptides.
Progress in clinical and biological research 1990;328():223-6.
1990: Bronstein D; Akil H
Effects of electrical stimulation in the periaqueductal gray on POMC peptides and mRNA in the rat brain.
Progress in clinical and biological research 1990;328():219-22.
1990: Day R; Schafer M K; Watson S J; Akil H
Effect of hypophysectomy on dynorphin mRNA and peptide content in the rat adrenal gland.
Progress in clinical and biological research 1990;328():207-10.
1990: Trujillo K A; Akil H
Opioid and non-opioid behavioral actions of dynorphin A and the dynorphin analogue DAKLI.
NIDA research monograph 1990;105():397-8.
1989: Herman J P; Schäfer K H; Sladek C D; Day R; Young E A; Akil H; Watson S J
Chronic electroconvulsive shock treatment elicits up-regulation of CRF and AVP mRNA in select populations of neuroendocrine neurons.
Brain research 1989;501(2):235-46.
1989: Herman J P; Patel P D; Akil H; Watson S J
Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat.
Molecular endocrinology (Baltimore, Md.) 1989;3(11):1886-94.
1989: Herman J P; Schäfer M K; Young E A; Thompson R; Douglass J; Akil H; Watson S J
Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(9):3072-82.
1989: Young E A; Houghten R A; Akil H
Degradation of [3H]beta-endorphin in rat plasma is increased with chronic stress.
European journal of pharmacology 1989;167(2):229-36.
1989: Minth C D; Qiu H; Akil H; Watson S J; Dixon J E
Two precursors of melanin-concentrating hormone: DNA sequence analysis and in situ immunochemical localization.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4292-6.
1989: Day R; Akil H
The posttranslational processing of prodynorphin in the rat anterior pituitary.
Endocrinology 1989;124(5):2392-405.
1989: Meador-Woodruff J H; Silk K R; Kronfol Z; Watson S J; Akil H
Gamma-melanotropin and beta-endorphin after dexamethasone.
Biological psychiatry 1989;25(7):975-6.
1989: Trujillo K A; Akil H
Changes in prodynorphin peptide content following treatment with morphine or amphetamine: possible role in mechanisms of action of drug of abuse.
NIDA research monograph 1989;95():550-1.
1988: Sherman T G; Day R; Civelli O; Douglass J; Herbert E; Akil H; Watson S J
Regulation of hypothalamic magnocellular neuropeptides and their mRNAs in the Brattleboro rat: coordinate responses to further osmotic challenge.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(10):3785-96.
1988: Mosberg H I; Haaseth R C; Ramalingam K; Mansour A; Akil H; Woodard R W
Role of steric interactions in the delta opioid receptor selectivity of [D-Pen2, D-Pen5]enkephalin.
International journal of peptide and protein research 1988;32(1):1-8.
1988: Mansour A; Khachaturian H; Lewis M E; Akil H; Watson S J
Anatomy of CNS opioid receptors.
Trends in neurosciences 1988;11(7):308-14.
1988: Meador-Woodruff J H; Pellerito B; Vaudry H; Jégou S; Seidah N G; Watson S J; Akil H
Regional processing of the N- and C-terminal domains of proopiomelanocortin in monkey pituitary and brain.
Neuropeptides 1988;11(3):111-8.
1988: Watson S J; Lopez J F; Young E A; Vale W; Rivier J; Akil H
Effects of low dose ovine corticotropin-releasing hormone in humans: endocrine relationships and beta-endorphin/beta-lipotropin responses.
The Journal of clinical endocrinology and metabolism 1988;66(1):10-5.
1988: Bronstein D; Trujillio K; Akil H
Effects of morphine treatment on endogenous opioid biosynthesis.
NIDA research monograph 1988;90():256-65.
1988: Young E A; Akil H
Paradoxical effect of corticosteroids on pituitary ACTH/beta-endorphin release in stressed animals.
Psychoneuroendocrinology 1988;13(4):317-23.
1987: Lewis J W; Baldrighi G; Akil H
A possible interface between autonomic function and pain control: opioid analgesia and the nucleus tractus solitarius.
Brain research 1987;424(1):65-70.
1987: Meador-Woodruff J H; Haskett R F; Grunhaus L; Akil H; Watson S J; Greden J F
Postdexamethasone plasma cortisol and beta-endorphin levels in depression: relationship to severity of illness.
Biological psychiatry 1987;22(9):1137-50.
1987: Walker J M; Coy D H; Young E A; Baldrighi G; Siegel S F; Bowen W D; Akil H
[D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN): a potent analog of dynorphin 1-13.
Peptides 1987;8(5):811-7.
1987: Mansour A; Khachaturian H; Lewis M E; Akil H; Watson S J
Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(8):2445-64.
1987: Robinson T E; Becker J B; Young E A; Akil H; Castaneda E
The effects of footshock stress on regional brain dopamine metabolism and pituitary beta-endorphin release in rats previously sensitized to amphetamine.
Neuropharmacology 1987;26(7A):679-91.
1987: Young E A; Walker J M; Houghten R; Akil H
The degradation of dynorphin A in brain tissue in vivo and in vitro.
Peptides 1987;8(4):701-7.
1987: Meador-Woodruff J H; Watson S J; Murphy-Weinberg V; Jegou S; Vaudry H; Seidah N G; Rivier J; Vale W; Akil H
Gamma-melanotropin response to ovine corticotropin releasing factor in normal humans.
Neuropeptides 1987;9(4):269-82.
1987: Dores R M; Akil H
Species-specific processing of prodynorphin in the posterior pituitary of mammals.
Endocrinology 1987;120(1):230-8.
1987: Lewis J; Mansour A; Khachaturian H; Watson S J; Akil H
Opioids and pain regulation.
Pain and headache 1987;9():129-59.
1986: Mansour A; Lewis M E; Khachaturian H; Akil H; Watson S J
Pharmacological and anatomical evidence of selective mu, delta, and kappa opioid receptor binding in rat brain.
Brain research 1986;399(1):69-79.
1986: Shiomi H; Watson S J; Kelsey J E; Akil H
Pretranslational and posttranslational mechanisms for regulating beta-endorphin-adrenocorticotropin of the anterior pituitary lobe.
Endocrinology 1986;119(4):1793-9.
1986: Schteingart D E; Lloyd R V; Akil H; Chandler W F; Ibarra-Perez G; Rosen S G; Ogletree R
Cushing's syndrome secondary to ectopic corticotropin-releasing hormone-adrenocorticotropin secretion.
The Journal of clinical endocrinology and metabolism 1986;63(3):770-5.
1986: Khachaturian H; Sherman T G; Lloyd R V; Civelli O; Douglass J; Herbert E; Akil H; Watson S J
Pro-dynorphin is endogenous to the anterior pituitary and is co-localized with LH and FSH in the gonadotrophs.
Endocrinology 1986;119(3):1409-11.
1986: Lewis M E; Sherman T G; Burke S; Akil H; Davis L G; Arentzen R; Watson S J
Detection of proopiomelanocortin mRNA by in situ hybridization with an oligonucleotide probe.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(15):5419-23.
1986: Tsou K; Khachaturian H; Akil H; Watson S J
Immunocytochemical localization of pro-opiomelanocortin-derived peptides in the adult rat spinal cord.
Brain research 1986;378(1):28-35.
1986: Dores R M; Jain M; Akil H
Characterization of the forms of beta-endorphin and alpha-MSH in the caudal medulla of the rat and guinea pig.
Brain research 1986;377(2):251-60.
1986: Young E A; Lewis J; Akil H
The preferential release of beta-endorphin from the anterior pituitary lobe by corticotropin releasing factor (CRF).
Peptides 1986;7(4):603-7.
1986: Khachaturian H; Akil H; Brownstein M J; Olney J W; Voigt K H; Watson S J
Further characterization of the extra-arcuate alpha-melanocyte stimulating hormone-like material in hypothalamus: biochemical and anatomical studies.
Neuropeptides 1986;7(3):291-313.
1986: Matthews J; Akil H; Greden J; Charney D; Weinberg V; Rosenbaum A; Watson S J
beta-Endorphin/beta-lipotropin immunoreactivity in endogenous depression. Effect of dexamethasone.
Archives of general psychiatry 1986;43(4):374-81.
1986: Young E A; Walker J M; Lewis M E; Houghten R A; Woods J H; Akil H
[3H]dynorphin A binding and kappa selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain.
European journal of pharmacology 1986;121(3):355-65.
1986: Kelsey J E; Watson S J; Burke S; Akil H; Roberts J L
Characterization of proopiomelanocortin mRNA detected by in situ hybridization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(1):38-42.
1986: Saper C B; Akil H; Watson S J
Lateral hypothalamic innervation of the cerebral cortex: immunoreactive staining for a peptide resembling but immunochemically distinct from pituitary/arcuate alpha-melanocyte stimulating hormone.
Brain research bulletin 1986;16(1):107-20.
1986: Meador-Woodruff J; Knobloch M; Vaudry H; Seidah N G; Watson S J; Akil H
Gamma-3-MSH and beta-endorphin in monkey pituitary.
NIDA research monograph 1986;75():307-10.
1986: Day R; Akil H
Bridge peptide is a cleavage product of pro-dynorphin processing in the rat anterior pituitary.
NIDA research monograph 1986;75():244-6.
1986: Mansour A; Lewis M E; Khachaturian H; Akil H; Watson S J
Multiple opioid receptor subtypes in the pituitary-adrenal axis: a cross-species study.
NIDA research monograph 1986;75():311-4.
1986: Taylor L; Mansour A; Watson S J; Akil H
Anomalous binding of DPDPE as a result of batch variability.
NIDA research monograph 1986;75():201-4.
1985: Akil H; Richardson D E
Contrast medium cause the apparent increase in beta-endorphin levels in human CSF following brain stimulation.
Pain 1985;23(3):301-4.
1985: Young E A; Akil H
Corticotropin-releasing factor stimulation of adrenocorticotropin and beta-endorphin release: effects of acute and chronic stress.
Endocrinology 1985;117(1):23-30.
1985: Young E; Akil H
Changes in releasability of ACTH and beta-endorphin with chronic stress.
Neuropeptides 1985;5(4-6):545-8.
1985: Dores R M; Lewis M E; Khachaturian H; Watson S J; Akil H
Analysis of opioid and non-opioid end products of pro-dynorphin in the substantia nigra of the rat.
Neuropeptides 1985;5(4-6):501-4.
1985: Akil H; Shiomi H; Matthews J
Induction of the intermediate pituitary by stress: synthesis and release of a nonopioid form of beta-endorphin.
Science (New York, N.Y.) 1985;227(4685):424-6.
1985: Khachaturian H; Lewis M E; Haber S N; Houghten R A; Akil H; Watson S J
Prodynorphin peptide immunocytochemistry in rhesus monkey brain.
Peptides 1985;6 Suppl 2():155-66.
1985: Dores R M; Akil H
Steady state levels of pro-dynorphin-related end products in the striatum and substantia nigra of the adult rhesus monkey.
Peptides 1985;6 Suppl 2():143-8.
1984: Lewis M E; Khachaturian H; Akil H; Watson S J
Anatomical relationship between opioid peptides and receptors in rhesus monkey brain.
Brain research bulletin 1984;13(6):801-12.
1984: Khachaturian H; Lewis M E; Haber S N; Akil H; Watson S J
Proopiomelanocortin peptide immunocytochemistry in rhesus monkey brain.
Brain research bulletin 1984;13(6):785-800.
1984: Lewis J W; Lewis M E; Loomus D J; Akil H
Acute systemic administration of morphine selectively increases mu opioid receptor binding in the rat brain.
Neuropeptides 1984;5(1-3):117-20.
1984: Dores R M; Khachaturian H; Watson S J; Akil H
Localization of neurons containing pro-opiomelanocortin-related peptides in the hypothalamus and midbrain of the lizard, Anolis carolinensis: evidence for region-specific processing of beta-endorphin.
Brain research 1984;324(2):384-9.
1984: Khachaturian H; Dores R M; Watson S J; Akil H
Beta-endorphin/ACTH immunocytochemistry in the CNS of the lizard Anolis carolinensis: evidence for a major mesencephalic cell group.
The Journal of comparative neurology 1984;229(4):576-84.
1984: Lewis M E; Young E A; Houghten R A; Akil H; Watson S J
Binding of [3H]dynorphin A to apparent kappa opioid receptors in deep layers of guinea pig cerebral cortex.
European journal of pharmacology 1984;98(1):149-50.
1984: Dores R M; Akil H; Watson S J
Strategies for studying opioid peptide regulation at the gene, message and protein levels.
Peptides 1984;5 Suppl 1():9-17.
1983: Young E A; Walker J M; Houghten R; Akil H
[3H]Dynorphin A binds selectively to guinea pig brain.
European journal of pharmacology 1983;91(2-3):327-8.
1983: Young E; Olney J; Akil H
Selective alterations of opiate receptor subtypes in monosodium glutamate-treated rats.
Journal of neurochemistry 1983;40(6):1558-64.
1983: Cahill C A; Matthews J D; Akil H
Human plasma beta-endorphin-like peptides: a rapid, high recovery extraction technique and validation of radioimmunoassay.
The Journal of clinical endocrinology and metabolism 1983;56(5):992-7.
1983: Watson S J; Khachaturian H; Taylor L; Fischli W; Goldstein A; Akil H
Pro-dynorphin peptides are found in the same neurons throughout rat brain: immunocytochemical study.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(3):891-4.
1983: Akil H; Lin H L; Ueda Y; Knobloch M; Watson S J; Coy D
Some of the alpha-NH2-acetylated beta-endorphin-like material in rat and monkey pituitary and brain is acetylated alpha- and beta-endorphin.
Life sciences 1983;33 Suppl 1():9-12.
1983: Cahill C; Watson S J; Knobloch M; Akil H
POMC in rhesus anterior pituitary and plasma: evidence of N-acetylated beta-endorphin and alpha-MSH.
Life sciences 1983;33 Suppl 1():53-5.
1983: Alessi N E; Khachaturian H; Watson S; Akil H
Postnatal ontogeny of acetylated and non-acetylated B-endorphin in rat pituitary.
Life sciences 1983;33 Suppl 1():57-60.
1983: Young E; Walker J M; Houghten R; Akil H
[3H] dynorphin binding to guinea pig and rat brain.
Life sciences 1983;33 Suppl 1():287-90.
1982: Walker J M; Moises H C; Coy D H; Baldrighi G; Akil H
Nonopiate effects of dynorphin and des-Tyr-dynorphin.
Science (New York, N.Y.) 1982;218(4577):1136-8.
1982: Watson S J; Khachaturian H; Akil H; Coy D H; Goldstein A
Comparison of the distribution of dynorphin systems and enkephalin systems in brain.
Science (New York, N.Y.) 1982;218(4577):1134-6.
1982: Walker J M; Tucker D E; Coy D H; Walker B B; Akil H
Des-tyrosine-dynorphin antagonizes morphine analgesia.
European journal of pharmacology 1982;85(1):121-2.
1982: Shiomi H; Akil H
Pulse-chase studies of the POMC/beta-endorphin system in the pituitary of acutely and chronically stressed rats.
Life sciences 1982;31(20-21):2185-8.
1982: Akil H; Shiomi H; Thompson R; Lax S; Coy D; Watson S
The signal peptide of pro-opiomelancortin: validation of a specific radioimmunoassay.
Life sciences 1982;31(20-21):2271-3.
1982: Khachaturian H; Watson S J; Lewis M E; Coy D; Goldstein A; Akil H
Dynorphin immunocytochemistry in the rat central nervous system.
Peptides 1982;3(6):941-54.
1982: Alessi N; Taylor L; Akil H
Peptide F (pro-enkephalin fragment): radioimmunoassay, and stress-induced changes in adrenal.
Life sciences 1982;31(16-17):1875-8.
1982: Cahill C; Akil H
Plasma beta-endorphin-like immunoreactivity, self reported pain perception and anxiety levels in women during pregnancy and labor.
Life sciences 1982;31(16-17):1871-3.
1982: Matthews J; Akil H; Greden J; Watson S
Plasma measures of B-endorphin-like immunoreactivity in depressives and other psychiatric subjects.
Life sciences 1982;31(16-17):1867-70.
1982: Walker J M; Moises H C; Coy D H; Young E A; Watson S J; Akil H
Dynorphin (1-17): lack of analgesia but evidence for non-opiate electrophysiological and motor effects.
Life sciences 1982;31(16-17):1821-4.
1982: Watson S J; Khachaturian H; Coy D; Taylor L; Akil H
Dynorphin is located throughout the CNS and is often co-localized with alpha-neo-endorphin.
Life sciences 1982;31(16-17):1773-6.
1982: Young E; Olney J; Akil H
Increase in delta, but not mu, receptors in MSG-treated rats.
Life sciences 1982;31(12-13):1343-6.
1982: Watson S J; Akil H; Fischli W; Goldstein A; Zimmerman E; Nilaver G; van wimersma Griedanus T B
Dynorphin and vasopressin: common localization in magnocellular neurons.
Science (New York, N.Y.) 1982;216(4541):85-7.
1981: Berger P A; Watson S J; Akil H; Barchas J D
The effects of naloxone in chronic schizophrenia.
The American journal of psychiatry 1981;138(7):913-8.
1981: Watson S J; Akil H; Ghazarossian V E; Goldstein A
Dynorphin immunocytochemical localization in brain and peripheral nervous system: preliminary studies.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):1260-3.
1981: Walker J M; Berntson G G; Sandman C A; Kastin A J; Akil H
Induction of analgesia by central administration of ORG 2766, an analog of ACTH4--9.
European journal of pharmacology 1981;69(1):71-9.
1981: Akil H; Young E; Watson S J; Coy D H
Opiate binding properties of naturally occurring N- and C-terminus modified beta-endorphins.
Peptides 1981;2(3):289-92.
1980: Walker J M; Akil H; Watson S J
Evidence for homologous actions of pro-opiocortin products.
Science (New York, N.Y.) 1980;210(4475):1247-9.
1980: Berger P A; Watson S J; Akil H; Elliott G R; Rubin R T; Pfefferbaum A; Davis K L; Barchas J D; Li C H
beta-Endorphin and schizophrenia.
Archives of general psychiatry 1980;37(6):635-40.
1980: Akil H; Hewlett W A; Barchas J D; Li C H
Binding of 3H-beta-endorphin to rat brain membranes: characterization of opiate properties and interaction with ACTH.
European journal of pharmacology 1980;64(1):1-8.
1980: Watson S J; Akil H
alpha-MSH in rat brain: occurrence within and outside of beta-endorphin neurons.
Brain research 1980;182(1):217-23.
1980: Walker J M; Katz R J; Akil H
Behavioral effects of dynorphin 1-13 in the mouse and rat: initial observations.
Peptides 1980;1(4):341-5.
1980: Sullivan S; Akil H; Blacker D; Barchas J D
Enkephalinase: selective inhibitors and partial characterization.
Peptides 1980;1(1):31-5.
1979: Watson S J; Akil H
The presence of two alpha-MSH positive cell groups in rat hypothalamus.
European journal of pharmacology 1979;58(1):101-3.
1979: Berger P A; Watson S J; Akil H; Barchas J D
Prospects for the evaluation of endorphins as psychotropic agents.
Psychopharmacology bulletin 1979;15(3):33-5.
1979: Akil H; Watson S J; Barchas J D; Li C H
B-ETA-Endorphin immunoreactivity in rat and human blood: radioimmunoassay, comparative levels and physiological alterations.
Life sciences 1979;24(18):1659-65.
1979: Watson S J; Akil H; Berger P A; Barchas J D
Some observations on the opiate peptides and schizophrenia.
Archives of general psychiatry 1979;36(1):35-41.
1978: Akil H; Richardson D E; Barchas J D; Li C H
Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(10):5170-2.
1978: Watson S J; Akil H; Richard C W; Barchas J D
Evidence for two separate opiate peptide neuronal systems.
Nature 1978;275(5677):226-8.
1978: Akil H; Richardson D E; Hughes J; Barchas J D
Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation.
Science (New York, N.Y.) 1978;201(4354):463-5.
1978: Watson S J; Berger P A; Akil H; Mills M J; Barchas J D
Effects of naloxone on schizophrenia: reduction in hallucinations in a subpopulation of subjects.
Science (New York, N.Y.) 1978;201(4350):73-6.
1978: Akil H; Watson S J; Sullivan S; Barchas J D
Enkephalin-like material in normal human CSF: measurement and levels.
Life sciences 1978;23(2):121-5.
1978: Barchas J D; Akil H; Elliott G R; Holman R B; Watson S J
Behavioral neurochemistry: neuroregulators and behavioral states.
Science (New York, N.Y.) 1978;200(4344):964-73.
1978: Sullivan S; Akil H; Barchas J D
In vitro degradation of enkephalin: evidence for cleavage at the Gly-Phe bond.
Communications in psychopharmacology 1978;2(6):525-31.
1977: Watson S J; Akil H; Sullivan S; Barchas J D
Immunocytochemical localization of methionine enkephalin: preliminary observations.
Life sciences 1977;21(5):733-8.
1977: Richardson D E; Akil H
Pain reduction by electrical brain stimulation in man. Part 1: Acute administration in periaqueductal and periventricular sites.
Journal of neurosurgery 1977;47(2):178-83.
1977: Richardson D E; Akil H
Pain reduction by electrical brain stimulation in man. Part 2: Chronic self-administration in the periventricular gray matter.
Journal of neurosurgery 1977;47(2):184-94.
1977: Watson S J; Akil H; Barchas J D
A possible role for the dorsal periventricular catecholamine bundle in stimulation produced analgesia: a behavioral and histochemical study.
Brain research 1977;130(2):335-42.
1977: Madden J; Akil H; Patrick R L; Barchas J D
Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat.
Nature 1977;265(5592):358-60.
1977: Sullivan S; Akil H; Watson S J; Barchas J D
Antibodies to enkephalins: coupling of antigens and a specific methionine-enkephalin radioimmunoassay.
Communications in psychopharmacology 1977;1(6):605-10.
1976: Akil H; Mayer D J; Liebeskind J C
Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist.
Science (New York, N.Y.) 1976;191(4230):961-2.
1975: Akil H; Liebeskind J C
Monoaminergic mechanisms of stimulation-produced analgesia.
Brain research 1975;94(2):279-96.
1972: Akil H; Mayer D J; Liebeskind J C
[Monoaminergic mechanisms involved in analgesia caused by stimulation of the brain stem in rats]
Journal de physiologie 1972;65():Suppl:185A.
1972: Akil H; Mayer D J
Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor.
Brain research 1972;44(2):692-7.
1972: Akil H; Mayer D J; Liebeskind J C
[Comparison in the rat between analgesia induced by stimulation of periacqueducal gray matter and morphine analgesia]
Comptes rendus hebdomadaires des séances de l'Académie des sciences. Série D: Sciences naturelles 1972;274(26):3603-5.

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