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John Guy

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Hong Yu; Shannon E Boye; Sanford L Boye; Vince A Chiodo; Tsung-Han Chou; William W Hauswirth; Rajeshwari D Koilkonda; Alfred S Lewin; Sacide S Ozdemir; Vittorio porciatti; John Guy
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.
Fawzi Abukhalil; Byron Lam; John Guy
Visual observations of an American patient with Leber hereditary optic neuropathy after purported injections of stem cells in China.
Hong Yu; Sanford L Boye; Vince A Chiodo; Tsung-Han Chou; William W Hauswirth; Rajeshwari D Koilkonda; Alfred S Lewin; Sacide S Ozdemir; Vittorio porciatti; John Guy
Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice.

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All Publications

2012: Hong Yu; Shannon E Boye; Sanford L Boye; Vince A Chiodo; Tsung-Han Chou; William W Hauswirth; Rajeshwari D Koilkonda; Alfred S Lewin; Sacide S Ozdemir; Vittorio porciatti; John Guy
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(20):E1238-47.
2012: Fawzi Abukhalil; Byron Lam; John Guy
Visual observations of an American patient with Leber hereditary optic neuropathy after purported injections of stem cells in China.
Archives of ophthalmology 2012;130(4):532-4.
2012: Hong Yu; Sanford L Boye; Vince A Chiodo; Tsung-Han Chou; William W Hauswirth; Rajeshwari D Koilkonda; Alfred S Lewin; Sacide S Ozdemir; Vittorio porciatti; John Guy
Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice.
Molecular vision 2012;18():1668-83.
2011: Rajeshwari D Koilkonda; John Guy
Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside.
Journal of ophthalmology 2011;2011():179412.
2010: Byron Lam; William J Feuer; Fawzi Abukhalil; Vittorio porciatti; William W Hauswirth; John Guy
Leber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1.
Archives of ophthalmology 2010;128(9):1129-35.
2010: Rajeshwari D Koilkonda; Tsung-Han Chou; Vittorio porciatti; William W Hauswirth; John Guy
Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus.
Archives of ophthalmology 2010;128(7):876-83.
2010: Joshua Pasol; Gerry Shaw; Cui Yang; William Feuer; Randy Kardon; John Guy
Phosphorylated neurofilament heavy chain correlations to visual function, optical coherence tomography, and treatment.
Multiple sclerosis international 2010;2010():542691.
2009: John Guy; Xiaoping Qi; Rajeshwari D Koilkonda; Tania Arguello; Tsung-Han Chou; Marco Ruggeri; Vittorio porciatti; Alfred S Lewin; William W Hauswirth
Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system.
Investigative ophthalmology & visual science 2009;50(9):4205-14.
2009: Rajeshwari D Koilkonda; William W Hauswirth; John Guy
Efficient expression of self-complementary AAV in ganglion cells of the ex vivo primate retina.
Molecular vision 2009;15():2796-802.
2008: John Guy
MRI in experimental inflammatory and mitochondrial optic neuropathies.
NMR in biomedicine 2008;21(9):968-77.
2008: Qiuhong Li; Adrian M Timmers; John Guy; Jijing Pang; William W Hauswirth
Cone-specific expression using a human red opsin promoter in recombinant AAV.
Vision research 2008;48(3):332-8.
2008: John Guy; Gerry Shaw; Fred N Ross-Cisneros; Peter Quiros; Solange R Salomao; Adriana Berezovsky; Valerio Carelli; William J Feuer; Alfredo Sadun
Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON).
Molecular vision 2008;14():2443-50.
2008: John Guy
Optic nerve degeneration in experimental autoimmune encephalomyelitis.
Ophthalmic research 2008;40(3-4):212-6.
2007: Clinton Sheets; Marc Peden; John Guy
Idiopathic intracranial hypertension in a transgender man.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2007;27(4):313-5.
2007: Xiaoping Qi; Liang Sun; Alfred S Lewin; William W Hauswirth; John Guy
Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy.
Investigative ophthalmology & visual science 2007;48(12):5360-70.
2007: Xiaoping Qi; Liang Sun; William W Hauswirth; Alfred S Lewin; John Guy
Use of mitochondrial antioxidant defenses for rescue of cells with a Leber hereditary optic neuropathy-causing mutation.
Archives of ophthalmology 2007;125(2):268-72.
2007: Xiaoping Qi; Alfred S Lewin; Liang Sun; William W Hauswirth; John Guy
Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis.
Investigative ophthalmology & visual science 2007;48(2):681-91.
2007: Hee-Jung Park; John Guy
Sixth nerve palsy post intravitreal bevacizumab for AMD: a new possibly causal relationship and complication?
Binocular vision & strabismus quarterly 2007;22(4):209.
2007: Xiaoping Qi; William W Hauswirth; John Guy
Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis.
Molecular vision 2007;13():1-11.
2007: Xiaoping Qi; Liang Sun; Alfred S Lewin; William W Hauswirth; John Guy
The mutant human ND4 subunit of complex I induces optic neuropathy in the mouse.
Investigative ophthalmology & visual science 2007;48(1):1-10.
2006: Xiaoping Qi; Alfred S Lewin; Liang Sun; William W Hauswirth; John Guy
Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis.
The Journal of biological chemistry 2006;281(42):31950-62.
2006: M Tariq Bhatti; Stephen Eisenschenk; Steven N Roper; John Guy
Superior divisional third cranial nerve paresis: clinical and anatomical observations of 2 unique cases.
Archives of neurology 2006;63(5):771-6.
2004: Xiaoping Qi; Alfred S Lewin; Liang Sun; William W Hauswirth; John Guy
SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I.
Annals of neurology 2004;56(2):182-91.
2003: John Guy
127th annual meeting of the American Neurological Association, New York, New York, October 13-16, 2002.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2003;23(3):236-9.
2003: Xiaoping Qi; Alfred S Lewin; William W Hauswirth; John Guy
Optic neuropathy induced by reductions in mitochondrial superoxide dismutase.
Investigative ophthalmology & visual science 2003;44(3):1088-96.
2003: Xiaoping Qi; Alfred S Lewin; William W Hauswirth; John Guy
Suppression of complex I gene expression induces optic neuropathy.
Annals of neurology 2003;53(2):198-205.
2002: John Guy; Xiaoping Qi; Francesco Pallotti; Eric A Schon; Giovanni Manfredi; Valerio Carelli; Andrea Martinuzzi; William W Hauswirth; Alfred S Lewin
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
Annals of neurology 2002;52(5):534-42.
2002: Giovanni Manfredi; Jin Fu; Joseline Ojaimi; James E Sadlock; Jennifer Q Kwong; John Guy; Eric A Schon
Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.
Nature genetics 2002;30(4):394-9.
2000: John Guy
New therapies for optic neuropathies: development in experimental models.
Current opinion in ophthalmology 2000;11(6):421-9.
2000: I V Owen R; A P Lewin; AL Peel; Jianming Wang; John Guy; William W Hauswirth; Peter W Stacpoole; Terence R Flotte
Recombinant adeno-associated virus vector-based gene transfer for defects in oxidative metabolism.
Human gene therapy 2000;11(15):2067-78.
1999: John Guy; Xiaoping Qi; H Wang; William W Hauswirth
Adenoviral gene therapy with catalase suppresses experimental optic neuritis.
Archives of ophthalmology 1999;117(11):1533-9.
1999: John Guy; Xiaoping Qi; Nicholas Muzyczka; William W Hauswirth
Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve.
Archives of ophthalmology 1999;117(7):929-37.
1999: J P Harmon; V A Purvin; John Guy; N Aptsiauri; GP Sutton
Cancer-associated retinopathy in a patient with advanced epithelial ovarian carcinoma.
Gynecologic oncology 1999;73(3):430-2.
1999: John Guy; N Aptsiauri
Treatment of paraneoplastic visual loss with intravenous immunoglobulin: report of 3 cases.
Archives of ophthalmology 1999;117(4):471-7.
1998: John Guy; Xiaoping Qi; William W Hauswirth
Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13847-52.
1997: Xiaoping Qi; John Guy; H Nick; John Valentine; N Rao
Increase of manganese superoxide dismutase, but not of Cu/Zn-SOD, in experimental optic neuritis.
Investigative ophthalmology & visual science 1997;38(6):1203-12.
1996: Xiaoping Qi; John Guy
Localization of NADPH diaphorase/nitric oxide synthase in the optic nerve of the normal guinea pig: a light and electron microscopic study.
The Journal of comparative neurology 1996;370(3):396-404.
1996: Sergei Zolotukhin; Mark Potter; William W Hauswirth; John Guy; Nicholas Muzyczka
A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells.
Journal of virology 1996;70(7):4646-54.
1996: Grazyna Adamus; N Aptsiauri; John Guy; John R Heckenlively; J Flannery; Paul A Hargrave
The occurrence of serum autoantibodies against enolase in cancer-associated retinopathy.
Clinical immunology and immunopathology 1996;78(2):120-9.
1994: Suresh K Mukherji; R P Tart; J Fitzsimmons; CJ Belden; Susan P McGorray; John Guy; Anthony A Mancuso
Fat-suppressed MR of the orbit and cavernous sinus: comparison of fast spin-echo and conventional spin-echo.
AJNR. American journal of neuroradiology 1994;15(9):1707-14.
1994: John Guy; Susan P McGorray; J Fitzsimmons; B Beck; A Mancuso; N A Rao; LM Hamed
Reversals of blood-brain barrier disruption by catalase: a serial magnetic resonance imaging study of experimental optic neuritis.
Investigative ophthalmology & visual science 1994;35(9):3456-65.
1994: Curtis E Margo; R N Mames; John Guy
Endogenous Klebsiella endophthalmitis. Report of two cases and review of the literature.
Ophthalmology 1994;101(7):1298-301.
1994: John Guy; Susan P McGorray; J Fitzsimmons; B Beck; N A Rao
Disruption of the blood-brain barrier in experimental optic neuritis: immunocytochemical co-localization of H2O2 and extravasated serum albumin.
Investigative ophthalmology & visual science 1994;35(3):1114-23.
1994: John Guy; Susan P McGorray; Xiaoping Qi; J Fitzsimmons; A Mancuso; N Rao
Conjugated deferoxamine reduces blood-brain barrier disruption in experimental optic neuritis.
Ophthalmic research 1994;26(5):310-23.
1993: Maria B Grant; R N Mames; C Fitzgerald; E Ann Ellis; Sergio Caballero; N Chegini; John Guy
Insulin-like growth factor I as an angiogenic agent. In vivo and in vitro studies.
Annals of the New York Academy of Sciences 1993;692():230-42.
1993: Grazyna Adamus; John Guy; J L Schmied; Anatol Arendt; Paul A Hargrave
Role of anti-recoverin autoantibodies in cancer-associated retinopathy.
Investigative ophthalmology & visual science 1993;34(9):2626-33.
1993: LM Hamed; J Silbiger; M Silbiger; R Quisling; M Fanous; JA Arrington; John Guy
Magnetic resonance angiography of vascular lesions causing neuro-ophthalmic deficits.
Survey of ophthalmology 1993;37(6):425-34.
1993: Maria B Grant; R N Mames; C Fitzgerald; E Ann Ellis; M Aboufriekha; John Guy
Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor.
Diabetologia 1993;36(4):282-91.
1993: LM Hamed; J Silbiger; John Guy; J Parker Mickle; P Sibony; A Cossari; M Andriola
Parainfectious optic neuritis and encephalomyelitis. A report of two cases with thalamic involvement.
Journal of clinical neuro-ophthalmology 1993;13(1):18-23.
1993: John Guy; E Ann Ellis; R Mames; N A Rao
Role of hydrogen peroxide in experimental optic neuritis. A serial quantitative ultrastructural study.
Ophthalmic research 1993;25(4):253-64.
1992: LM Hamed; John Guy; M L Moster; Thomas Bosley
Giant cell arteritis in the ocular ischemic syndrome.
American journal of ophthalmology 1992;113(6):702-5.
1992: John Guy; J Fitzsimmons; E Ann Ellis; B Beck; A Mancuso
Intraorbital optic nerve and experimental optic neuritis. Correlation of fat suppression magnetic resonance imaging and electron microscopy.
Ophthalmology 1992;99(5):720-5.
1992: John Guy; J Mao; Willis Bidgood; A Mancuso; Ronald G Quisling
Enhancement and demyelination of the intraorbital optic nerve. Fat suppression magnetic resonance imaging.
Ophthalmology 1992;99(5):713-9.
1992: S A Strelow; Mark B Sherwood; L J Broncato; A Napier; William T Driebe; John Guy; F F Vickers; K Mellars
The effect of diclofenac sodium ophthalmic solution on intraocular pressure following cataract extraction.
Ophthalmic surgery 1992;23(3):170-5.
1991: R N Mames; L Snady-McCoy; John Guy
Central retinal and posterior ciliary artery occlusion after particle embolization of the external carotid artery system.
Ophthalmology 1991;98(4):527-31.
1991: John Guy; A Mancuso; R Beck; M L Moster; L A Sedwick; Ronald G Quisling; Albert L Rhoton; E E Protzko; J Schiffman
Radiation-induced optic neuropathy: a magnetic resonance imaging study.
Journal of neurosurgery 1991;74(3):426-32.
1991: John Guy; E Ann Ellis; G M Hope; Scott S Emerson
Maintenance of myelinated fibre g ratio in acute experimental allergic encephalomyelitis.
Brain : a journal of neurology 1991;114 ( Pt 1A)():281-94.
1990: John Guy; E Ann Ellis; N A Rao
Hydrogen peroxide localization in experimental optic neuritis.
Archives of ophthalmology 1990;108(11):1614-21.
1990: John Guy; N J Schatz
Effectiveness of hyperbaric oxygen in treating radiation injury to the optic nerves and chiasm.
Ophthalmology 1990;97(10):1246-7.
1990: John Guy; J Fitzsimmons; E Ann Ellis; A Mancuso
Gadolinium-DTPA-enhanced magnetic resonance imaging in experimental optic neuritis.
Ophthalmology 1990;97(5):601-7.
1990: John Guy; A Mancuso; Ronald G Quisling; R Beck; M Moster
Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies.
Ophthalmology 1990;97(5):592-9; discussion 599-600.
1990: John Guy; P K Johnston; J J Corbett; A L Day; J S Glaser
Treatment of visual loss in pseudotumor cerebri associated with uremia.
Neurology 1990;40(1):28-32.
1989: John Guy; E Ann Ellis; K Kelley; G M Hope
Spectra of G ratio, myelin sheath thickness, and axon and fiber diameter in the guinea pig optic nerve.
The Journal of comparative neurology 1989;287(4):446-54.
1989: John Guy; E Ann Ellis; G M Hope; N A Rao
Antioxidant enzymes reduce loss of blood-brain barrier integrity in experimental optic neuritis.
Archives of ophthalmology 1989;107(9):1359-63.
1989: John Guy; H M Engel; A M Lessner
Acquired contralateral oculomotor synkinesis.
Archives of neurology 1989;46(9):1021-3.
1989: John Guy; Ronald G Quisling
Ectopic lacrimal gland presenting as an orbital mass in childhood.
AJNR. American journal of neuroradiology 1989;10(5 Suppl):S92.
1989: John Guy; Arthur L Day
Intracranial aneurysms with superior division paresis of the oculomotor nerve.
Ophthalmology 1989;96(7):1071-6.
1989: John Guy; S Fagien; J P Donovan; M L Rubin
Methylprednisolone pulse therapy in severe dysthyroid optic neuropathy.
Ophthalmology 1989;96(7):1048-52; discussion 1052-3.
1989: John Guy; N T Feldberg; P J Savino; N J Schatz; Robert Sergott
T-lymphocyte subpopulations in acute unilateral optic neuritis.
Ophthalmology 1989;96(7):1054-7.
1989: John Guy; W F Friedman; J Parker Mickle
Bilateral trochlear nerve paresis in hydrocephalus.
Journal of clinical neuro-ophthalmology 1989;9(2):105-11.
1989: John Guy; E Ann Ellis; G M Hope; N A Rao
Antioxidant enzyme suppression of demyelination in experimental optic neuritis.
Current eye research 1989;8(5):467-77.
1989: John Guy; M Sherwood; Arthur L Day
Surgical treatment of progressive visual loss in traumatic optic neuropathy. Report of two cases.
Journal of neurosurgery 1989;70(5):799-801.
1989: John Guy; E Ann Ellis; E F Tark; G M Hope; N A Rao
Axonal transport reductions in acute experimental allergic encephalomyelitis: qualitative analysis of the optic nerve.
Current eye research 1989;8(3):261-9.
1989: John Guy; E Ann Ellis; K Kelley; G M Hope; N A Rao
Quantitative analysis of labelled inner retinal proteins in experimental optic neuritis.
Current eye research 1989;8(3):253-60.
1989: John Guy; Arthur L Day; J Parker Mickle; N J Schatz
Contralateral trochlear nerve paresis and ipsilateral Horner's syndrome.
American journal of ophthalmology 1989;107(1):73-6.
1988: John Guy; N J Schatz
Paraneoplastic downbeating nystagmus. A sign of occult malignancy.
Journal of clinical neuro-ophthalmology 1988;8(4):269-72.
1986: John Guy; N J Schatz
Hyperbaric oxygen in the treatment of radiation-induced optic neuropathy.
Ophthalmology 1986;93(8):1083-8.
1986: John Guy; E Ann Ellis; G M Hope; N A Rao
Influence of antioxidant enzymes in reduction of optic disc edema in experimental optic neuritis.
Journal of free radicals in biology & medicine 1986;2(5-6):349-57.
1984: John Guy; N A Rao
Acute and chronic experimental optic neuritis. Alteration in the blood-optic nerve barrier.
Archives of ophthalmology 1984;102(3):450-4.
1981: N A Rao; John Guy; P S Sheffield
Effects of chronic demyelination on axonal transport in experimental allergic optic neuritis.
Investigative ophthalmology & visual science 1981;21(4):606-11.
1979: Harry A Quigley; John Guy; Douglas R Anderson
Blockade of rapid axonal transport. Effect of intraocular pressure elevation in primate optic nerve.
Archives of ophthalmology 1979;97(3):525-31.
1978: John Guy; Harry A Quigley; Douglas R Anderson
The effect of biogenic monomines on rapid axonal transport in the rabbit optic nerve.
Investigative ophthalmology & visual science 1978;17(3):296-300.