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Jian Li

Research Profile

Chemicals & Drugs

Physiology

Drug Resistance, Multiple, Bacterial

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Publications

TOP 3
Stephanie J Wallace; Jian Li; Roger L Nation; Ben J Boyd
Physicochemical aspects of the coformulation of colistin and azithromycin using liposomes for combination antibiotic therapies.
Jennifer H Moffatt; Roger L Nation; Ben Adler; Bethany Crane; Timothy C Fitzsimons; Marina Harper; Jian Li; Ashley Mansell; John D Boyce
Lipopolysaccharide-deficient Acinetobacter baumannii shows altered signaling through host Toll-like receptors and increased susceptibility to the host antimicrobial peptide LL-37.
Tony Velkov; Mohammad Ak Azad; Mark A Baker; Pei L Chong; Abigail Clements; Matthew A Cooper; Johnny X Huang; Roger L Nation; Kade Roberts; Rachel L Soon; Richard A Strugnell; Philip E Thompson; Jian Li
Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.

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All Publications

2013: Stephanie J Wallace; Jian Li; Roger L Nation; Ben J Boyd
Physicochemical aspects of the coformulation of colistin and azithromycin using liposomes for combination antibiotic therapies.
Journal of pharmaceutical sciences 2013;102(5):1578-87.
2013: Jennifer H Moffatt; Roger L Nation; Ben Adler; Bethany Crane; Timothy C Fitzsimons; Marina Harper; Jian Li; Ashley Mansell; John D Boyce
Lipopolysaccharide-deficient Acinetobacter baumannii shows altered signaling through host Toll-like receptors and increased susceptibility to the host antimicrobial peptide LL-37.
Infection and immunity 2013;81(3):684-9.
2013: Tony Velkov; Mohammad Ak Azad; Mark A Baker; Pei L Chong; Abigail Clements; Matthew A Cooper; Johnny X Huang; Roger L Nation; Kade Roberts; Rachel L Soon; Richard A Strugnell; Philip E Thompson; Jian Li
Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.
Innate immunity 2013;19(3):265-77.
2012: Phillip J Bergen; Cornelia B Landersdorfer; Hee Ji Lee; Jian Li; Roger L Nation
'Old' antibiotics for emerging multidrug-resistant bacteria.
Current opinion in infectious diseases 2012;25(6):626-33.
2012: Liang Jin; Jian Li; Roger L Nation; Joseph A Nicolazzo
Effect of systemic infection induced by Pseudomonas aeruginosa on the brain uptake of colistin in mice.
Antimicrobial agents and chemotherapy 2012;56(10):5240-6.
2012: Zakuan Z Deris; Alan Forrest; Jovan Jacob; Caron K Ku; Jian Li; David L Paterson; Anima Poudyal; Rachel L Soon; Brian T Tsuji; Tony Velkov; Heidi H Yu; Phillip J Bergen; Jürgen Bulitta; Kathryn Davis; Roger L Nation
The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model.
Antimicrobial agents and chemotherapy 2012;56(10):5103-12.
2012: R L Soon; Ben Adler; John D Boyce; Marina Harper; Ian Larson; Jian Li; Roger L Nation
Cell surface hydrophobicity of colistin-susceptible vs resistant Acinetobacter baumannii determined by contact angles: methodological considerations and implications.
Journal of applied microbiology 2012;113(4):940-51.
2012: Stephanie J Wallace; Jian Li; Roger L Nation; Richard J Prankerd; Ben J Boyd
Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation.
Journal of pharmaceutical sciences 2012;101(9):3347-59.
2012: Mohammad A K Azad; Matthew A Cooper; Johnny X Huang; Jian Li; Roger L Nation; Kade D Roberts; Philip E Thompson; Tony Velkov
Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.
Biochemical pharmacology 2012;84(3):278-91.
2012: Chin Fen Neoh; Angela Stathopoulos; Kay Stewart; Jovan Jacob; Lok Leung; Jian Li; David C M Kong
Stability of extemporaneously prepared 0.5-percent caspofungin eye drops: a potential cost-savings exercise.
Antimicrobial agents and chemotherapy 2012;56(6):3435-7.
2011: Rachel L Soon; Chun-Hong Tan; Jian Li; Roger L Nation; Ben Adler; John D Boyce; Marina Harper; Ian Larson
Effect of colistin exposure and growth phase on the surface properties of live Acinetobacter baumannii cells examined by atomic force microscopy.
International journal of antimicrobial agents 2011;38(6):493-501.
2011: Phillip J Bergen; Jürgen Bulitta; Alan Forrest; Jovan Jacob; Roger L Nation; David L Paterson; Hanna E Sidjabat; Brian T Tsuji; Jian Li
Synergistic killing of multidrug-resistant Pseudomonas aeruginosa at multiple inocula by colistin combined with doripenem in an in vitro pharmacokinetic/pharmacodynamic model.
Antimicrobial agents and chemotherapy 2011;55(12):5685-95.
2011: Phillip J Bergen; Jürgen Bulitta; Alan Forrest; Jian Li; David L Paterson; Hanna E Sidjabat; Brian T Tsuji; Roger L Nation
Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula.
Antimicrobial agents and chemotherapy 2011;55(11):5134-42.
2011: Phillip J Bergen; Jian Li; Roger L Nation
Dosing of colistin-back to basic PK/PD.
Current opinion in pharmacology 2011;11(5):464-9.
2011: Jumana M Yousef; Roger L Nation; Gong Chen; Prue A Hill; Jian Li
Melatonin attenuates colistin-induced nephrotoxicity in rats.
Antimicrobial agents and chemotherapy 2011;55(9):4044-9.
2011: S M Garonzik; J Jacob; Jian Li; David L Paterson; S Shoham; F P Silveira; V Thamlikitkul; A Forrest; Roger L Nation
Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients.
Antimicrobial agents and chemotherapy 2011;55(7):3284-94.
2011: Jennifer H Moffatt; Marina Harper; Ben Adler; Roger L Nation; Jian Li; John D Boyce
Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii.
Antimicrobial agents and chemotherapy 2011;55(6):3022-4.
2011: Rachel L Soon; Tony Velkov; Francis Chiu; Philip E Thompson; Rashmi Kancharla; Kade Roberts; Ian Larson; Roger L Nation; Jian Li
Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions.
Analytical biochemistry 2011;409(2):273-83.
2011: Liang Jin; Jian Li; Roger L Nation; Joseph A Nicolazzo
Impact of p-glycoprotein inhibition and lipopolysaccharide administration on blood-brain barrier transport of colistin in mice.
Antimicrobial agents and chemotherapy 2011;55(2):502-7.
2011: Rachel L Soon; Roger L Nation; Stewart Cockram; Jennifer H Moffatt; Marina Harper; Ben Adler; John D Boyce; Ian Larson; Jian Li
Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment.
The Journal of antimicrobial chemotherapy 2011;66(1):126-33.
2010: Jennifer H Moffatt; Marina Harper; Paul Harrison; John D F Hale; Evgeny Vinogradov; Torsten Seemann; Rebekah Henry; Bethany Crane; Frank St Michael; Andrew D Cox; Ben Adler; Roger L Nation; Jian Li; John D Boyce
Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production.
Antimicrobial agents and chemotherapy 2010;54(12):4971-7.
2010: Phillip J Bergen; Jurgen B Bulitta; Alan Forrest; Brian T Tsuji; Jian Li; Roger L Nation
Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model.
Antimicrobial agents and chemotherapy 2010;54(9):3783-9.
2010: Rajesh V Dudhani; John D Turnidge; Roger L Nation; Jian Li
fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.
The Journal of antimicrobial chemotherapy 2010;65(9):1984-90.
2010: Rajesh V Dudhani; Roger L Nation; Jian Li
Evaluating the stability of colistin and colistin methanesulphonate in human plasma under different conditions of storage.
The Journal of antimicrobial chemotherapy 2010;65(7):1412-5.
2010: Stephanie J Wallace; Jian Li; Roger L Nation; Richard J Prankerd; Tony Velkov; Ben J Boyd
Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization.
The journal of physical chemistry. B 2010;114(14):4836-40.
2010: Rajesh V Dudhani; John D Turnidge; Kingsley Coulthard; Robert W Milne; Craig R Rayner; Jian Li; Roger L Nation
Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models.
Antimicrobial agents and chemotherapy 2010;54(3):1117-24.
2009: Roger L Nation; Jian Li
Colistin in the 21st century.
Current opinion in infectious diseases 2009;22(6):535-43.
2009: Rachel L Soon; Roger L Nation; Patrick G Hartley; Ian Larson; Jian Li
Atomic force microscopy investigation of the morphology and topography of colistin-heteroresistant Acinetobacter baumannii strains as a function of growth phase and in response to colistin treatment.
Antimicrobial agents and chemotherapy 2009;53(12):4979-86.
2009: Feda' Emad Atta Ali; Guoying Cao; Anima Poudyal; Timo Vaara; Roger L Nation; Martti Vaara; Jian Li
Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration.
The Journal of antimicrobial chemotherapy 2009;64(5):1067-70.
2009: Liang Jin; Jian Li; Roger L Nation; Joseph A Nicolazzo
Brain penetration of colistin in mice assessed by a novel high-performance liquid chromatographic technique.
Antimicrobial agents and chemotherapy 2009;53(10):4247-51.
2009: Daoud Al-Badriyeh; Jian Li; Kay Stewart; David C M Kong; Lok Leung; Geoffrey E Davies; Robert Fullinfaw
Stability of extemporaneously prepared voriconazole ophthalmic solution.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2009;66(16):1478-83.
2009: Zheng Ma; Jiping Wang; Roger L Nation; Jian Li; John D Turnidge; Kingsley Coulthard; Robert W Milne
Renal disposition of colistin in the isolated perfused rat kidney.
Antimicrobial agents and chemotherapy 2009;53(7):2857-64.
2009: Wing Yau; Roxanne J Owen; Anima Poudyal; Jan M Bell; John D Turnidge; Heidi H Yu; Roger L Nation; Jian Li
Colistin hetero-resistance in multidrug-resistant Acinetobacter baumannii clinical isolates from the Western Pacific region in the SENTRY antimicrobial surveillance programme.
The Journal of infection 2009;58(2):138-44.
2008: Anima Poudyal; Benjamin P Howden; Jan M Bell; Wei Gao; Roxanne J Owen; John D Turnidge; Roger L Nation; Jian Li
In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae.
The Journal of antimicrobial chemotherapy 2008;62(6):1311-8.
2008: Guoying Cao; Feda' Emad Atta Ali; Francis Chiu; Alexandre P Zavascki; Roger L Nation; Jian Li
Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma.
The Journal of antimicrobial chemotherapy 2008;62(5):1009-14.
2008: Stephanie J Wallace; Jian Li; craig rayner; Kingsley Coulthard; Roger L Nation
Stability of colistin methanesulfonate in pharmaceutical products and solutions for administration to patients.
Antimicrobial agents and chemotherapy 2008;52(9):3047-51.
2008: Sreeja Sudhakaran; craig rayner; Jian Li; David C M Kong; Neil M Gude; Roger L Nation
Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus.
British journal of clinical pharmacology 2008;65(5):667-73.
2008: Phillip J Bergen; Jian Li; Roger L Nation; John D Turnidge; Kingsley Coulthard; Robert W Milne
Comparison of once-, twice- and thrice-daily dosing of colistin on antibacterial effect and emergence of resistance: studies with Pseudomonas aeruginosa in an in vitro pharmacodynamic model.
The Journal of antimicrobial chemotherapy 2008;61(3):636-42.
2008: Stephanie J Wallace; Jian Li; Roger L Nation; craig rayner; David Taylor; Deborah Middleton; Robert W Milne; Kingsley Coulthard; John D Turnidge
Subacute toxicity of colistin methanesulfonate in rats: comparison of various intravenous dosage regimens.
Antimicrobial agents and chemotherapy 2008;52(3):1159-61.
2007: Roger L Nation; Jian Li
Optimizing use of colistin and polymyxin B in the critically ill.
Seminars in respiratory and critical care medicine 2007;28(6):604-14.
2007: Jian Li; Roger L Nation; Roxanne J Owen; Stephanie Wong; Denis Spelman; Clare Franklin
Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45(5):594-8.
2007: Chun-Hong Tan; Jian Li; Roger L Nation
Activity of colistin against heteroresistant Acinetobacter baumannii and emergence of resistance in an in vitro pharmacokinetic/pharmacodynamic model.
Antimicrobial agents and chemotherapy 2007;51(9):3413-5.
2007: Lauren M Boak; Jian Li; craig rayner; Roger L Nation
Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model.
Antimicrobial agents and chemotherapy 2007;51(4):1287-92.
2007: Roxanne J Owen; Jian Li; Roger L Nation; Denis Spelman
In vitro pharmacodynamics of colistin against Acinetobacter baumannii clinical isolates.
The Journal of antimicrobial chemotherapy 2007;59(3):473-7.
2007: Sreeja Sudhakaran; craig rayner; Jian Li; David C M Kong; Neil M Gude; Roger L Nation
Differential protein binding of indinavir and saquinavir in matched maternal and umbilical cord plasma.
British journal of clinical pharmacology 2007;63(3):315-21.
2006: Jian Li; craig rayner; Roger L Nation; Roxanne J Owen; Denis Spelman; Kar Eng Tan; Lisa Liolios
Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii.
Antimicrobial agents and chemotherapy 2006;50(9):2946-50.
2006: Jian Li; Roger L Nation; John D Turnidge; Robert W Milne; Kingsley Coulthard; craig rayner; David L Paterson
Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections.
The Lancet infectious diseases 2006;6(9):589-601.
2006: Lauren M Boak; Jian Li; Roger L Nation; craig rayner
High-performance liquid chromatographic method for simple and rapid determination of linezolid in human plasma.
Biomedical chromatography : BMC 2006;20(8):782-6.
2006: Lauren M Boak; Jian Li; Denis Spelman; Philipp du Cros; Roger L Nation; craig rayner
Successful treatment and cerebrospinal fluid penetration of oral linezolid in a patient with coagulase-negative Staphylococcus ventriculitis.
The Annals of pharmacotherapy 2006;40(7-8):1451-5.
2006: Phillip J Bergen; Jian Li; craig rayner; Roger L Nation
Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 2006;50(6):1953-8.
2006: Jiping Wang; Roger L Nation; Allan M Evans; Susan Cox; Jian Li
Determination of antiviral nucleoside analogues AM365 and AM188 in perfusate and bile of the isolated perfused rat liver using HPLC.
Biomedical chromatography : BMC 2006;20(3):244-50.
2005: Jian Li; Roger L Nation; Robert W Milne; John D Turnidge; Kingsley Coulthard
Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria.
International journal of antimicrobial agents 2005;25(1):11-25.
2004: Jian Li; craig rayner; Roger L Nation
Simple method for the assay of eperezolid in brain heart infusion broth by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis 2004;35(4):847-51.
2004: Jian Li; Robert W Milne; Roger L Nation; John D Turnidge; Timothy C Smeaton; Kingsley Coulthard
Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate.
The Journal of antimicrobial chemotherapy 2004;53(5):837-40.
2004: Jian Li; craig rayner; Shirley Dixson; Roger L Nation
Simple method for the assay of linezolid in Brain Heart Infusion broth by high-performance liquid chromatography.
Biomedical chromatography : BMC 2004;18(1):1-5.
2003: Jian Li; Kingsley Coulthard; Robert Milne; Roger L Nation; Steven Conway; Daniel G Peckham; Christine Etherington; John D Turnidge
Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis.
The Journal of antimicrobial chemotherapy 2003;52(6):987-92.
2003: Jian Li; Robert W Milne; Roger L Nation; John D Turnidge; Timothy C Smeaton; Kingsley Coulthard
Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration.
Antimicrobial agents and chemotherapy 2003;47(5):1766-70.
2003: Jian Li; Robert W Milne; Roger L Nation; John D Turnidge; Kingsley Coulthard
Stability of colistin and colistin methanesulfonate in aqueous media and plasma as determined by high-performance liquid chromatography.
Antimicrobial agents and chemotherapy 2003;47(4):1364-70.
2002: Jian Li; Robert W Milne; Roger L Nation; John D Turnidge; Kingsley Coulthard; Jason Valentine
Simple method for assaying colistin methanesulfonate in plasma and urine using high-performance liquid chromatography.
Antimicrobial agents and chemotherapy 2002;46(10):3304-7.
2001: Jian Li; Robert W Milne; Roger L Nation; John D Turnidge; Kingsley Coulthard; D W Johnson
A simple method for the assay of colistin in human plasma, using pre-column derivatization with 9-fluorenylmethyl chloroformate in solid-phase extraction cartridges and reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;761(2):167-75.
2001: Jian Li; John D Turnidge; R Milne; Roger L Nation; Kingsley Coulthard
In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Antimicrobial agents and chemotherapy 2001;45(3):781-5.