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Victor Hruby

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
108
Yamamura, Henry
54
Porreca, Frank
53
Hadley, Mac
44
Trivedi, Dev
41
Davis, Peg
28
Knapp, Richard
28
Lai, Josephine
25
Cai, Minying
23
Davis, Thomas
23
Misicka, Aleksandra
23
Vanderah, Todd
21
Lipkowski, Andrzej
20
al-Obeidi, FA
19
Ma, Shou-wu
19
Roeske, William

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Publications

TOP 3
Yamamoto Takashi; Nair Padma; Ma Shou-wu; Davis Peg; Yamamura Henry I; Vanderah Todd W; Porreca Frank; Lai Josephine; Hruby Victor J
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Vardanyan Ruben; Vijay Gokhale; Nichol Gary S; Liu Lu; Kumarasinghe Isuru; Davis Peg; Vanderah Todd; Porreca Frank; Lai Josephine; Hruby Victor J
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
Kumarasinghe Isuru R; Hruby Victor J; Nichol Gary S
3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl ether-water (2/0.72/1/1).

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All Publications

2009: Yamamoto Takashi; Nair Padma; Ma Shou-wu; Davis Peg; Yamamura Henry I; Vanderah Todd W; Porreca Frank; Lai Josephine; Hruby Victor J
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Bioorganic & medicinal chemistry 2009;17(20):7337-43.
2009: Vardanyan Ruben; Vijay Gokhale; Nichol Gary S; Liu Lu; Kumarasinghe Isuru; Davis Peg; Vanderah Todd; Porreca Frank; Lai Josephine; Hruby Victor J
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
Bioorganic & medicinal chemistry 2009;17(14):5044-53.
2009: Kumarasinghe Isuru R; Hruby Victor J; Nichol Gary S
3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl ether-water (2/0.72/1/1).
Acta crystallographica. Section C, Crystal structure communications 2009;65(Pt 6):o296-9.
2009: Qu Hongchang; Cai Minying; Mayorov Alexander V; Grieco Paolo; Zingsheim Morgan; Trivedi Dev; Hruby Victor J
Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.
Journal of medicinal chemistry 2009;52(12):3627-35.
2009: Josan Jatinder S; Morse David L; Xu Liping; Trissal Maria; Baggett Brenda; Davis Peg; Vagner Josef; Gillies Robert J; Hruby Victor J
Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging.
Organic letters 2009;11(12):2479-82.
2009: Kumarasinghe Isuru R; Hruby Victor J; Nichol Gary S
3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propionic acid and the corresponding methyl ester.
Acta crystallographica. Section C, Crystal structure communications 2009;65(Pt 4):o163-6.
2009: Zhang Wenjun; Gardell Shannon; Zhang Dongqin; Xie Jennifer Y; Agnes Richard S; Badghisi Hamid; Hruby Victor J; Rance Naomi; Ossipov Michael H; Vanderah Todd W; Porreca Frank; Lai Josephine
Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors.
Brain : a journal of neurology 2009;132(Pt 3):778-87.
2009: Cai Minying; Nyberg Joel; Hruby Victor J
Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems.
Current topics in medicinal chemistry 2009;9(6):554-63.
2009: Nair Padma; Yamamoto Takashi; Kulkarni Vinod; Moye Sharif; Navratilova Edita; Davis Peg; Largent Tally; Ma Shou-Wu; Yamamura Henry I; Vanderah Todd; Lai Josephine; Porreca Frank; Hruby Victor J
Novel bifunctional peptides as opioid agonists and NK-1 antagonists.
Advances in experimental medicine and biology 2009;611():537-8.
2009: Lee YeonSun; Petrov Ravil; Kulkarni Vinod; Min Byoung J; Ma Shou-Wu; Davis Peg; Oyarzo Janice; Vanderah Todd; Lai Josephine; Porreca Frank; Vardanyan Ruben; Hruby Victor J
Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.
Advances in experimental medicine and biology 2009;611():517-8.
2009: Fernandes Steve M; Sankaranarayanan Rajesh; Xu Liping; Josan Jatinder; Vagner Josef; Gillies Robert; Hruby Victor J
Synthesis of bivalent MSH ligands and evaluation of their binding to hMC4R using MSH lanthaligand.
Advances in experimental medicine and biology 2009;611():433-4.
2009: Josan Jatinder S; Sankaranarayanan Rajesh; Handl Heather L; Fernandes Steve; Xu Liping; Vagner Josef; Gillies Robert J; Hruby Victor J
Heterobivalent ligands crosslink multiple cell-surface receptors--a step towards personal medicine.
Advances in experimental medicine and biology 2009;611():413-4.
2009: Hruby Victor J; Cai Minying; Dedek Matt; Qu Hongchang; Palmer Erin; Mayorov Alexander; Trivedi Dev; Tsaprailis George; Yang Yingqui
Peptide and non-peptide mimetics utilize different pathways for signal transduction.
Advances in experimental medicine and biology 2009;611():305-7.
2009: Kulkarni Vinod V; Lee Yeon Sun; Salibay Christine; Davis Peg; Ma Shou-Wu; Porreca Frank; Hruby Victor J
Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor.
Advances in experimental medicine and biology 2009;611():195-6.
2008: Yamamoto Takashi; Nair Padma; Jacobsen Neil E; Davis Peg; Ma Shou-wu; Navratilova Edita; Moye Sharif; Lai Josephine; Yamamura Henry I; Vanderah Todd W; Porreca Frank; Hruby Victor J
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6334-47.
2008: Balagurunathan Yoganand; Morse David L; Hostetter Galen; Shanmugam Vijayalakshmi; Stafford Phillip; Shack Sonsoles; Pearson John; Trissal Maria; Demeure Michael J; Von Hoff Daniel D; Hruby Victor J; Gillies Robert J; Han Haiyong
Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer.
Molecular cancer therapeutics 2008;7(9):3071-80.
2008: Liu Zhihua; Qu Hongchang; Gu Xuyuan; Min Byoung J; Nichol Gary S; Nyberg Joel; Hruby Victor J
Enantioselective synthesis of anti-beta-substituted gamma,delta-unsaturated amino acids: a highly selective asymmetric thio-Claisen rearrangement.
Organic letters 2008;10(18):4105-8.
2008: Agnes Richard S; Ying Jinfa; Kövér Katalin E; Lee Yeon Sun; Davis Peg; Ma Shou-wu; Badghisi Hamid; Porreca Frank; Lai Josephine; Hruby Victor J
Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Peptides 2008;29(8):1413-23.
2008: Vagner Josef; Qu Hongchang; Hruby Victor J
Peptidomimetics, a synthetic tool of drug discovery.
Current opinion in chemical biology 2008;12(3):292-6.
2008: Grieco Paolo; Cai Minying; Liu Lu; Mayorov Alexander; Chandler Kevin; Trivedi Dev; Lin Guangxin; Campiglia Pietro; Novellino Ettore; Hruby Victor J
Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.
Journal of medicinal chemistry 2008;51(9):2701-7.
2008: Yamamoto Takashi; Nair Padma; Vagner Josef; Largent-Milnes Tally; Davis Peg; Ma Shou-Wu; Navratilova Edita; Moye Sharif; Tumati Suneeta; Lai Josephine; Yamamura Henry I; Vanderah Todd W; Porreca Frank; Hruby Victor J
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(5):1369-76.
2008: Georgieva Teodora; Devanathan Savitha; Stropova Dagmar; Park Chad K; Salamon Zdzislaw; Tollin Gordon; Hruby Victor J; Roeske William R; Yamamura Henry I; Varga Eva
Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.
European journal of pharmacology 2008;581(1-2):19-29.
2008: Mayorov Alexander V; Cai Minying; Palmer Erin S; Dedek Matthew M; Cain James P; Van Scoy April R; Tan Bahar; Vagner Josef; Trivedi Dev; Hruby Victor J
Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.
Journal of medicinal chemistry 2008;51(2):187-95.
2008: Vagner Josef; Xu Liping; Handl Heather L; Josan Jatinder S; Morse David L; Mash Eugene A; Gillies Robert J; Hruby Victor J
Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors.
Angewandte Chemie (International ed. in English) 2008;47(9):1685-8.
2008: Lee Yeon Sun; Agnes Richard S; Cain James P; Kulkarni Vinod; Cai Minying; Salibay Christine; Ciano Kathy; Petrov Ravil; Mayorov Alexander; Vagner Josef; Trivedi Dev; Davis Peg; Ma Shou-wu; Lai Josephine; Porreca Frank; Vardanyan Ruben; Hruby Victor J
Opioid and melanocortin receptors: do they have overlapping pharmacophores?
Biopolymers 2008;90(3):433-8.
2007: Lee Yeon Sun; Petrov Ravil; Park Chad K; Ma Shou-wu; Davis Peg; Lai Josephine; Porreca Frank; Vardanyan Ruben; Hruby Victor J
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
Journal of medicinal chemistry 2007;50(22):5528-32.
2007: Hruby Victor J; Tollin Gordon
Plasmon-waveguide resonance (PWR) spectroscopy for directly viewing rates of GPCR/G-protein interactions and quantifying affinities.
Current opinion in pharmacology 2007;7(5):507-14.
2007: Qu Hongchang; Gu Xuyuan; Liu Zhihua; Min Byoung J; Hruby Victor J
Asymmetric Eschenmoser-Claisen rearrangement for anti-beta-substituted gamma,delta-unsaturated amino acids.
Organic letters 2007;9(20):3997-4000.
2007: Handl Heather L; Sankaranarayanan Rajesh; Josan Jatinder S; Vagner Josef; Mash Eugene A; Gillies Robert J; Hruby Victor J
Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R).
Bioconjugate chemistry 2007;18(4):1101-9.
2007: Mollica Adriano; Guardiani Giovanni; Davis Peg; Ma Shou-Wu; Porreca Frank; Lai Josephine; Mannina Luisa; Sobolev Anatoli P; Hruby Victor J
Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.
Journal of medicinal chemistry 2007;50(13):3138-42.
2007: Yamamoto Takashi; Nair Padma; Davis Peg; Ma Shou-wu; Navratilova Edita; Moye Sharif; Tumati Suneeta; Lai Josephine; Vanderah Todd W; Yamamura Henry I; Porreca Frank; Hruby Victor J
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Journal of medicinal chemistry 2007;50(12):2779-86.
2007: Grieco Paolo; Cai Minying; Han Guoxia; Trivedi Dev; Campiglia Pietro; Novellino Ettore; Hruby Victor J
Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
Peptides 2007;28(6):1191-6.
2007: Jagadish Bhumasamudram; Sankaranarayanan Rajesh; Xu Liping; Richards Reyniak; Vagner Josef; Hruby Victor J; Gillies Robert J; Mash Eugene A
Squalene-derived flexible linkers for bioactive peptides.
Bioorganic & medicinal chemistry letters 2007;17(12):3310-3.
2007: Hruby Victor J
Professor Mac E. Hadley: creative scientist, superb teacher, dynamic collaborator and wonderful friend.
General and comparative endocrinology 2007;151(3):358-60.
2007: Navratilova Edita; Waite Sue; Stropova Dagmar; Eaton Miriam C; Alves Isabel D; Hruby Victor J; Roeske William R; Yamamura Henry I; Varga Eva V
Quantitative evaluation of human delta opioid receptor desensitization using the operational model of drug action.
Molecular pharmacology 2007;71(5):1416-26.
2007: Ballet Steven; Mayorov Alexander V; Cai Minying; Tymecka Dagmara; Chandler Kevin B; Palmer Erin S; Rompaey Karolien Van; Misicka Aleksandra; Tourwé Dirk; Hruby Victor J
Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold.
Bioorganic & medicinal chemistry letters 2007;17(9):2492-8.
2007: Lee Yeon Sun; Nyberg Joel; Moye Sharif; Agnes Richard S; Davis Peg; Ma Shou-wu; Lai Josephine; Porreca Frank; Vardanyan Ruben; Hruby Victor J
Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.
Bioorganic & medicinal chemistry letters 2007;17(8):2161-5.
2007: Zhou Min; Nakatani Eri; Gronenberg Luisa S; Tokimoto Takahira; Wirth Mary J; Hruby Victor J; Roberts Amber; Lynch Ronald M; Ghosh Indraneel
Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules.
Bioconjugate chemistry 2007;18(2):323-32.
2007: Bowen Martina E; Monguchi Yasunari; Sankaranarayanan Rajesh; Vagner Josef; Begay Lucinda J; Xu Liping; Jagadish Bhumasamudram; Hruby Victor J; Gillies Robert J; Mash Eugene A
Design, synthesis, and validation of a branched flexible linker for bioactive peptides.
The Journal of organic chemistry 2007;72(5):1675-80.
2007: Lee Yeon Sun; Agnes Richard S; Davis Peg; Ma Shou-wu; Badghisi Hamid; Lai Josephine; Porreca Frank; Hruby Victor J
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Journal of medicinal chemistry 2007;50(1):165-8.
2007: King Stephen H; Mayorov Alexander V; Balse-Srinivasan Preeti; Hruby Victor J; Vanderah Todd W; Wessells Hunter
Melanocortin receptors, melanotropic peptides and penile erection.
Current topics in medicinal chemistry 2007;7(11):1098-1106.
2007: Hruby Victor J; Cai Minying; Cain James P; Mayorov Alexander V; Dedek Matthew M; Trivedi Devendra
Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor.
Current topics in medicinal chemistry 2007;7(11):1107-19.
2006: Ying Jinfa; Gu Xuyuan; Cai Minying; Dedek Matthew; Vagner Josef; Trivedi Dev B; Hruby Victor J
Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor.
Journal of medicinal chemistry 2006;49(23):6888-96.
2006: Vagner Josef; Handl Heather L; Monguchi Yasunari; Jana Umasish; Begay Lucinda J; Mash Eugene A; Hruby Victor J; Gillies Robert J
Rigid linkers for bioactive peptides.
Bioconjugate chemistry 2006;17(6):1545-50.
2006: Cai Minying; Varga Eva V; Stankova Magda; Mayorov Alexander; Perry Joseph W; Yamamura Henry I; Trivedi Dev; Hruby Victor J
Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists.
Chemical biology & drug design 2006;68(4):183-93.
2006: Cain James P; Mayorov Alexander V; Cai Minying; Wang Hui; Tan Bahar; Chandler Kevin; Lee YeonSun; Petrov Ravil R; Trivedi Dev; Hruby Victor J
Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors.
Bioorganic & medicinal chemistry letters 2006;16(20):5462-7.
2006: Qu Hongchang; Gu Xuyuan; Min Byoung J; Liu Zhihua; Hruby Victor J
Synthesis of Anti-beta-substituted gamma,delta-unsaturated amino acids via Eschenmoser-Claisen rearrangement.
Organic letters 2006;8(19):4215-8.
2006: Petrov Ravil R; Vardanyan Ruben S; Lee Yeon S; Ma Shou-wu; Davis Peg; Begay Lucinda J; Lai Josephine Y; Porreca Frank; Hruby Victor J
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.
Bioorganic & medicinal chemistry letters 2006;16(18):4946-50.
2006: Mayorov Alexander V; Han So-Yeop; Cai Minying; Hammer Matthew R; Trivedi Dev; Hruby Victor J
Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs.
Chemical biology & drug design 2006;67(5):329-35.
2006: Agnes Richard S; Lee Yeon Sun; Davis Peg; Ma Shou-Wu; Badghisi Hamid; Porreca Frank; Lai Josephine; Hruby Victor J
Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Journal of medicinal chemistry 2006;49(10):2868-75.
2006: Alves Isabel D; Delaroche Diane; Mouillac Bernard; Salamon Zdzislaw; Tollin Gordon; Hruby Victor J; Lavielle Solange; Sagan Sandrine
The two NK-1 binding sites correspond to distinct, independent, and non-interconvertible receptor conformational states as confirmed by plasmon-waveguide resonance spectroscopy.
Biochemistry 2006;45(16):5309-18.
2006: Mayorov Alexander V; Cai Minying; Chandler Kevin B; Petrov Ravil R; Van Scoy April R; Yu Zerui; Tanaka Dustin K; Trivedi Dev; Hruby Victor J
Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.
Journal of medicinal chemistry 2006;49(6):1946-52.
2006: Lee Yeon Sun; Agnes Richard S; Badghisi Hamid; Davis Peg; Ma Shou-wu; Lai Josephine; Porreca Frank; Hruby Victor J
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
Journal of medicinal chemistry 2006;49(5):1773-80.
2006: Grieco Paolo; Cai Minying; Mayorov Alexander V; Trivedi Dev; Hruby Victor J
Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position.
Peptides 2006;27(2):472-81.
2006: Mollica Adriano; Davis Peg; Ma Shou-Wu; Porreca Frank; Lai Josephine; Hruby Victor J
Synthesis and biological activity of the first cyclic biphalin analogues.
Bioorganic & medicinal chemistry letters 2006;16(2):367-72.
2006: Hruby Victor J; Porreca Frank; Yamamura Henry I; Tollin Gordon; Agnes Richard S; Lee Yeon Sun; Cai Minying; Alves Isabel; Cowell Scott; Varga Eva; Davis Peg; Salamon Zdzislaw; Roeske William; Vanderah Todd; Lai Josephine
New paradigms and tools in drug design for pain and addiction.
The AAPS journal 2006;8(3):E450-60.
2005: Soloshonok Vadim A; Cai Chaozhong; Yamada Takeshi; Ueki Hisanori; Ohfune Yasufumi; Hruby Victor J
Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity.
Journal of the American Chemical Society 2005;127(43):15296-303.
2005: Smith Emily A; Coym Jason W; Cowell Scott M; Tokimoto Takahira; Hruby Victor J; Yamamura Henry I; Wirth Mary J
Lipid bilayers on polyacrylamide brushes for inclusion of membrane proteins.
Langmuir : the ACS journal of surfaces and colloids 2005;21(21):9644-50.
2005: Alves I D; Park C K; Hruby V J
Plasmon resonance methods in GPCR signaling and other membrane events.
Current protein & peptide science 2005;6(4):293-312.
2005: Fung Selena; Hruby Victor J
Design of cyclic and other templates for potent and selective peptide alpha-MSH analogues.
Current opinion in chemical biology 2005;9(4):352-8.
2005: Handl Heather L; Vagner Josef; Yamamura Henry I; Hruby Victor J; Gillies Robert J
Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor.
Analytical biochemistry 2005;343(2):299-307.
2005: King Tamara; Gardell Luis R; Wang Ruizhong; Vardanyan Anna; Ossipov Michael H; Malan T Philip; Vanderah Todd W; Hunt Stephen P; Hruby Victor J; Lai Josephine; Porreca Frank
Role of NK-1 neurotransmission in opioid-induced hyperalgesia.
Pain 2005;116(3):276-88.
2005: Cai Minying; Mayorov Alexander V; Ying Jinfa; Stankova Magda; Trivedi Dev; Cabello Chris; Hruby Victor J
Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors.
Peptides 2005;26(8):1481-5.
2005: Alves Isabel D; Salamon Zdzislaw; Hruby Victor J; Tollin Gordon
Ligand modulation of lateral segregation of a G-protein-coupled receptor into lipid microdomains in sphingomyelin/phosphatidylcholine solid-supported bilayers.
Biochemistry 2005;44(25):9168-78.
2005: Mollica Adriano; Davis Peg; Ma Shou-Wu; Lai Josephine; Porreca Frank; Hruby Victor J
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.
Bioorganic & medicinal chemistry letters 2005;15(10):2471-5.
2005: Devanathan Savitha; Salamon Zdzislaw; Nagar Anoop; Narang Subhash; Schleich Donald; Darman Paul; Hruby Victor; Tollin Gordon
Subpicomolar sensing of delta-opioid receptor ligands by molecular-imprinted polymers using plasmon-waveguide resonance spectroscopy.
Analytical chemistry 2005;77(8):2569-74.
2005: Dhanasekaran Muthu; Palian Michael M; Alves Isabel; Yeomans Larisa; Keyari Charles M; Davis Peg; Bilsky Edward J; Egleton Richard D; Yamamura Henry I; Jacobsen Neil E; Tollin Gordon; Hruby Victor J; Porreca Frank; Polt Robin
Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers.
Journal of the American Chemical Society 2005;127(15):5435-48.
2005: Subramaniam Varuni; Alves Isabel D; Salgado Gilmar F J; Lau Pick-Wei; Wysocki Ronald J; Salamon Zdzislaw; Tollin Gordon; Hruby Victor J; Brown Michael F; Saavedra S Scott
Rhodopsin reconstituted into a planar-supported lipid bilayer retains photoactivity after cross-linking polymerization of lipid monomers.
Journal of the American Chemical Society 2005;127(15):5320-1.
2005: Cai Minying; Mayorov Alexander V; Cabello Christopher; Stankova Magda; Trivedi Dev; Hruby Victor J
Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues.
Journal of medicinal chemistry 2005;48(6):1839-48.
2005: Lin J; Liao S; Hruby V J
Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-amino-3, 3-diarylpropionic acids.
The journal of peptide research : official journal of the American Peptide Society 2005;65(1):105-12.
2005: Alves Isabel D; Salgado Gilmar F J; Salamon Zdzislaw; Brown Michael F; Tollin Gordon; Hruby Victor J
Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy.
Biophysical journal 2005;88(1):198-210.
2005: Gu Xuyuan; Ying Jinfa; Min Byoung; Cain James P; Davis Peg; Willey Patrick; Navratilova Edita; Yamamura Henry I; Porreca Frank; Hruby Victor J
Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues.
Biopolymers 2005;80(2-3):151-63.
2004: Handl Heather L; Vagner Josef; Han Haiyong; Mash Eugene; Hruby Victor J; Gillies Robert J
Hitting multiple targets with multimeric ligands.
Expert opinion on therapeutic targets 2004;8(6):565-86.
2004: Cowell S M; Lee Y S; Cain J P; Hruby V J
Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands.
Current medicinal chemistry 2004;11(21):2785-98.
2004: Ossipov Michael H; Lai Josephine; King Tamara; Vanderah Todd W; Malan T Philip; Hruby Victor J; Porreca Frank
Antinociceptive and nociceptive actions of opioids.
Journal of neurobiology 2004;61(1):126-48.
2004: Alves Isabel D; Ciano Kathy A; Boguslavski Valentina; Varga Eva; Salamon Zdzislaw; Yamamura Henry I; Hruby Victor J; Tollin Gordon
Selectivity, cooperativity, and reciprocity in the interactions between the delta-opioid receptor, its ligands, and G-proteins.
The Journal of biological chemistry 2004;279(43):44673-82.
2004: Elmagbari Nura O; Egleton Richard D; Palian Michael M; Lowery John J; Schmid Wendi R; Davis Peg; Navratilova Edita; Dhanasekaran Muthu; Keyari Charles M; Yamamura Henry I; Porreca Frank; Hruby Victor J; Polt Robin; Bilsky Edward J
Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides.
The Journal of pharmacology and experimental therapeutics 2004;311(1):290-7.
2004: Gu Xuyuan; Ying Jinfa; Agnes Richard S; Navratilova Edita; Davis Peg; Stahl Gannon; Porreca Frank; Yamamura Henry I; Hruby Victor J
Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues.
Organic letters 2004;6(19):3285-8.
2004: Soloshonok Vadim A; Ueki Hisanori; Tiwari Rohit; Cai Chaozhong; Hruby Victor J
Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines.
The Journal of organic chemistry 2004;69(15):4984-90.
2004: Handl Heather L; Vagner Josef; Yamamura Henry I; Hruby Victor J; Gillies Robert J
Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions.
Analytical biochemistry 2004;330(2):242-50.
2004: Cai Minying; Stankova Magda; Pond Stephanie J K; Mayorov Alexander V; Perry Joseph W; Yamamura Henry I; Trivedi Dev; Hruby Victor J
Real time differentiation of G-protein coupled receptor (GPCR) agonist and antagonist by two photon fluorescence laser microscopy.
Journal of the American Chemical Society 2004;126(23):7160-1.
2004: Alves Isabel; Cowell Scott; Lee Yeon Sun; Tang Xuejun; Davis Peg; Porreca Frank; Hruby Victor J
A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands.
Biochemical and biophysical research communications 2004;318(2):335-40.
2004: Alves Isabel D; Cowell Scott M; Salamon Zdzislaw; Devanathan Savitha; Tollin Gordon; Hruby Victor J
Different structural states of the proteolipid membrane are produced by ligand binding to the human delta-opioid receptor as shown by plasmon-waveguide resonance spectroscopy.
Molecular pharmacology 2004;65(5):1248-57.
2004: Han Guoxia; Haskell-Luevano Carrie; Kendall Laura; Bonner Gregg; Hadley Mac E; Cone Roger D; Hruby Victor J
De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.
Journal of medicinal chemistry 2004;47(6):1514-26.
2004: Cai M; Cai C; Mayorov A V; Xiong C; Cabello C M; Soloshonok V A; Swift J R; Trivedi D; Hruby V J
Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity.
The journal of peptide research : official journal of the American Peptide Society 2004;63(2):116-31.
2004: Vagner Josef; Handl Heather L; Gillies Robert J; Hruby Victor J
Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH.
Bioorganic & medicinal chemistry letters 2004;14(1):211-5.
2003: Tollin Gordon; Salamon Zdzislaw; Hruby Victor J
Techniques: plasmon-waveguide resonance (PWR) spectroscopy as a tool to study ligand-GPCR interactions.
Trends in pharmacological sciences 2003;24(12):655-9.
2003: Alves Isabel D; Salamon Zdzislaw; Varga Eva; Yamamura Henry I; Tollin Gordon; Hruby Victor J
Direct observation of G-protein binding to the human delta-opioid receptor using plasmon-waveguide resonance spectroscopy.
The Journal of biological chemistry 2003;278(49):48890-7.
2003: Balse-Srinivasan Preeti; Grieco Paolo; Cai Minying; Trivedi Dev; Hruby Victor J
Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues.
Journal of medicinal chemistry 2003;46(23):4965-73.
2003: Tollin Gordon; Salamon Zdzislaw; Cowell Scott; Hruby Victor J
Plasmon-waveguide resonance spectroscopy: a new tool for investigating signal transduction by G-protein coupled receptors.
Life sciences 2003;73(26):3307-11.
2003: Grieco P; Balse-Srinivasan P; Han G; Weinberg D; MacNeil T; Van der Ploeg L H T; Hruby V J
Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
The journal of peptide research : official journal of the American Peptide Society 2003;62(5):199-206.
2003: Hruby Victor J
Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes.
Journal of medicinal chemistry 2003;46(20):4215-31.
2003: Zhang Junyi; Xiong Chiyi; Ying Jinfa; Wang Wei; Hruby Victor J
Stereoselective synthesis of novel dipeptide beta-turn mimetics targeting melanocortin peptide receptors.
Organic letters 2003;5(17):3115-8.
2003: Balse-Srinivasan Preeti; Grieco Paolo; Cai Minying; Trivedi Dev; Hruby Victor J
Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R.
Journal of medicinal chemistry 2003;46(17):3728-33.
2003: Xiong Chiyi; Zhang Junyi; Davis Peg; Wang Wei; Ying Jinfa; Porreca Frank; Hruby Victor J
Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics.
Chemical communications (Cambridge, England) 2003;(13):1598-9.
2003: Varga Eva V; Rubenzik Marc K; Stropova Dagmar; Sugiyama Masano; Grife Vanessa; Hruby Victor J; Rice Kenner C; Roeske William R; Yamamura Henry I
Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment.
The Journal of pharmacology and experimental therapeutics 2003;306(1):109-15.
2003: Wessells Hunter; Hruby Victor J; Hackett John; Han Guoxia; Balse-Srinivasan Preeti; Vanderah Todd W
MT-II induces penile erection via brain and spinal mechanisms.
Annals of the New York Academy of Sciences 2003;994():90-5.
2003: Hruby Victor J; Cai Minying; Grieco Paolo; Han Guoxia; Kavarana Malcolm; Trivedi Dev
Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors.
Annals of the New York Academy of Sciences 2003;994():12-20.
2003: Hruby V J; Agnes R S; Davis P; Ma S-W; Lee Y S; Vanderah T W; Lai J; Porreca F
Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.
Life sciences 2003;73(6):699-704.
2003: Boguslavsky V; Hruby V J; O'Brien D F; Misicka A; Lipkowski A W
Effect of peptide conformation on membrane permeability.
The journal of peptide research : official journal of the American Peptide Society 2003;61(6):287-97.
2003: Mogil Jeffrey S; Wilson Sonya G; Chesler Elissa J; Rankin Andrew L; Nemmani Kumar V S; Lariviere William R; Groce M Kristina; Wallace Margaret R; Kaplan Lee; Staud Roland; Ness Timothy J; Glover Toni L; Stankova Magda; Mayorov Alexander; Hruby Victor J; Grisel Judith E; Fillingim Roger B
The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4867-72.
2003: Ying Jinfa; Ahn Jung-Mo; Jacobsen Neil E; Brown Michael F; Hruby Victor J
NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles.
Biochemistry 2003;42(10):2825-35.
2003: Han G; Quillan J M; Carlson K; Sadée W; Hruby V J
Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist.
Journal of medicinal chemistry 2003;46(5):810-9.
2003: Hosohata Keiko; Varga Eva V; Alfaro-Lopez Josue; Tang Xuejun; Vanderah Todd W; Porreca Frank; Hruby Victor J; Roeske William R; Yamamura Henry I
(2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain.
The Journal of pharmacology and experimental therapeutics 2003;304(2):683-8.
2003: Okura Takashi; Varga Eva V; Hosohata Yoshiaki; Navratilova Edita; Cowell Scott M; Rice Kenner; Nagase Hiroshi; Hruby Victor J; Roeske William R; Yamamura Henry I
Agonist-specific down-regulation of the human delta-opioid receptor.
European journal of pharmacology 2003;459(1):9-16.
2003: Ying Jinfa; Kövér Katalin E; Gu Xuyuan; Han Guoxia; Trivedi Dev B; Kavarana Malcolm J; Hruby Victor J
Solution structures of cyclic melanocortin agonists and antagonists by NMR.
Biopolymers 2003;71(6):696-716.
2003: Cowell Scott M; Gu Xuyuan; Vagner Josef; Hruby Victor J
Intelligent design in combinatorial chemistry: use of designed peptide libraries to explore secondary and tertiary structures in peptides and proteins.
Methods in enzymology 2003;369():288-97.
2003: Wessells H; Hruby V J; Hackett J; Han G; Balse-Srinivasan P; Vanderah T W
Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors.
Neuroscience 2003;118(3):755-62.
2002: Salamon Z; Hruby V J; Tollin G; Cowell S
Binding of agonists, antagonists and inverse agonists to the human delta-opioid receptor produces distinctly different conformational states distinguishable by plasmon-waveguide resonance spectroscopy.
The journal of peptide research : official journal of the American Peptide Society 2002;60(6):322-8.
2002: Grieco Paolo; Lavecchia Antonio; Cai Minying; Trivedi Devendra; Weinberg David; MacNeil Tanya; Van der Ploeg L H T; Hruby Victor J
Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.
Journal of medicinal chemistry 2002;45(24):5287-94.
2002: Zhang Junyi; Xiong Chiyi; Wang Wei; Ying Jinfa; Hruby Victor J
Stereoselective bromination-suzuki cross-coupling of dehydroamino acids to form novel reverse-turn peptidomimetics: substituted unsaturated and saturated indolizidinone amino acids.
Organic letters 2002;4(23):4029-32.
2002: Hruby Victor J
Designing peptide receptor agonists and antagonists.
Nature reviews. Drug discovery 2002;1(11):847-58.
2002: Wang Wei; Yang Jianqing; Ying Jinfa; Xiong Chiyi; Zhang Junyi; Cai Chaozhong; Hruby Victor J
Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters.
The Journal of organic chemistry 2002;67(18):6353-60.
2002: Kavarana Malcolm J; Trivedi Dev; Cai Minying; Ying Jinfa; Hammer Matthew; Cabello Christopher; Grieco Paolo; Han Guoxia; Hruby Victor J
Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors.
Journal of medicinal chemistry 2002;45(12):2644-50.
2002: Xiong Chiyi; Wang Wei; Hruby Victor J
A general asymmetric synthesis of syn- and anti-beta-substituted cysteine and serine derivatives.
The Journal of organic chemistry 2002;67(10):3514-7.
2002: Grieco P; Balse-Srinivasan P; Han G; Weinberg D; MacNeil T; Van der Ploeg L H T; Hruby V J
Synthesis and biological evaluation on hMC3, hMC4 and hMC5 receptors of gamma-MSH analogs substituted with L-alanine.
The journal of peptide research : official journal of the American Peptide Society 2002;59(5):203-10.
2002: Grieco Paolo; Han Guoxia; Weinberg David; Van der Ploeg L H T; Hruby Victor J
Design and synthesis of highly potent and selective melanotropin analogues of SHU9119 modified at position 6.
Biochemical and biophysical research communications 2002;292(4):1075-80.
2002: Xiong Chiyi; Wang Wei; Cai Chaozhong; Hruby Victor J
Regioselective and stereoselective nucleophilic ring opening reactions of a phenyl-substituted aziridine: enantioselective synthesis of beta-substituted tryptophan, cysteine, and serine derivatives.
The Journal of organic chemistry 2002;67(4):1399-402.
2002: Lipkowski Andrzej W; Misicka Aleksandra; Kosson Dariusz; Kosson Piotr; Lachwa-From Magdalena; Brodzik-Bienkowska Agnieszka; Hruby Victor J
Biological properties of a new fluorescent biphalin fragment analogue.
Life sciences 2002;70(8):893-7.
2002: Romanowski Marek; Zhu Xiaoyun; Kim Kathy; Hruby Victor J; O'Brien David F
Interaction of enkephalin peptides with anionic model membranes.
Biochimica et biophysica acta 2002;1558(1):45-53.
2002: Hruby Victor J; Qui Wei; Okayama Toru; Soloshonok Vadim A
Design of nonpeptides from peptide ligands for peptide receptors.
Methods in enzymology 2002;343():91-123.
2002: Hruby Victor J; Agnes Richard S; Cai Chaozhong
Design of peptide agonists.
Methods in enzymology 2002;343():73-91.
2002: Cowell Scott M; Balse-Srinivasan Preeti M; Ahn Jung-Mo; Hruby Victor J
Design and synthesis of peptide antagonists and inverse agonists for G protein-coupled receptors.
Methods in enzymology 2002;343():49-72.
2001: Han G; Tamaki M; Hruby V J
Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m).
The journal of peptide research : official journal of the American Peptide Society 2001;58(4):338-41.
2001: Ahn J M; Gitu P M; Medeiros M; Swift J R; Trivedi D; Hruby V J
A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning.
Journal of medicinal chemistry 2001;44(19):3109-16.
2001: Ahn J M; Medeiros M; Trivedi D; Hruby V J
Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4.
The journal of peptide research : official journal of the American Peptide Society 2001;58(2):151-8.
2001: Hruby V J
Design in topographical space of peptide and peptidomimetic ligands that affect behavior. A chemist's glimpse at the mind--body problem.
Accounts of chemical research 2001;34(5):389-97.
2001: Tamaki M; Han G; Hruby V J
Synthesis of 4-cis-phenyl-L-proline via hydrogenolysis.
The Journal of organic chemistry 2001;66(10):3593-6.
2001: Hosohata Y; Varga E V; Stropova D; Li X; Knapp R J; Hruby V J; Rice K C; Nagase H; Roeske W R; Yamamura H I
Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation.
Life sciences 2001;68(19-20):2233-42.
2001: Ahn J M; Medeiros M; Trivedi D; Hruby V J
Development of potent truncated glucagon antagonists.
Journal of medicinal chemistry 2001;44(9):1372-9.
2001: Mitchell S A; Pratt M R; Hruby V J; Polt R
Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin.
The Journal of organic chemistry 2001;66(7):2327-42.
2001: Grieco P; Gitu P M; Hruby V J
Preparation of 'side-chain-to-side-chain' cyclic peptides by Allyl and Alloc strategy: potential for library synthesis.
The journal of peptide research : official journal of the American Peptide Society 2001;57(3):250-6.
2001: Wang Z; Gardell L R; Ossipov M H; Vanderah T W; Brennan M B; Hochgeschwender U; Hruby V J; Malan T P; Lai J; Porreca F
Pronociceptive actions of dynorphin maintain chronic neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1779-86.
2001: Tamaki M; Han G; Hruby V J
Practical and efficient synthesis of orthogonally protected constrained 4-guanidinoprolines.
The Journal of organic chemistry 2001;66(3):1038-42.
2001: Soloshonok V A; Tang X; Hruby V J; Van Meervelt L
Asymmetric synthesis of alpha,beta-dialkyl-alpha-phenylalanines via direct alkylation of a chiral alanine derivative with racemic alpha-alkylbenzyl bromides. A case of high enantiomer differentiation at room temperature.
Organic letters 2001;3(3):341-3.
2001: Cai C; Soloshonok V A; Hruby V J
Michael addition reactions between chiral Ni(II) complex of glycine and 3-(trans-enoyl)oxazolidin-2-ones. A case of electron donor-acceptor attractive interaction-controlled face diastereoselectivity.
The Journal of organic chemistry 2001;66(4):1339-50.
2001: Lipkowski A W; Misicka A; Hosohata K; Davis P; Yamamura H I; Porreca F; Hruby V J
Biological properties of Phe(o)-opioid peptide analogues.
Life sciences 2001;68(8):969-72.
2000: Grieco P; Balse P M; Weinberg D; MacNeil T; Hruby V J
D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.
Journal of medicinal chemistry 2000;43(26):4998-5002.
2000: Salamon Z; Cowell S; Varga E; Yamamura H I; Hruby V J; Tollin G
Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.
Biophysical journal 2000;79(5):2463-74.
2000: Soloshonok V A; Cai C; Hruby V J; Van Meervelt L; Yamazaki T
Rational design of highly diastereoselective, organic base-catalyzed, room-temperature Michael addition reactions.
The Journal of organic chemistry 2000;65(20):6688-96.
2000: Dorr R T; Dvorakova K; Brooks C; Lines R; Levine N; Schram K; Miketova P; Hruby V; Alberts D S
Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-alpha-MSH in humans.
Photochemistry and photobiology 2000;72(4):526-32.
2000: Wessells H; Levine N; Hadley M E; Dorr R; Hruby V
Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.
International journal of impotence research 2000;12 Suppl 4():S74-9.
2000: Egleton R D; Mitchell S A; Huber J D; Janders J; Stropova D; Polt R; Yamamura H I; Hruby V J; Davis T P
Improved bioavailability to the brain of glycosylated Met-enkephalin analogs.
Brain research 2000;881(1):37-46.
2000: Wessells H; Gralnek D; Dorr R; Hruby V J; Hadley M E; Levine N
Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.
Urology 2000;56(4):641-6.
2000: Hruby V J; Balse P M
Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads.
Current medicinal chemistry 2000;7(9):945-70.
2000: Balse P M; Kim H J; Han G; Hruby V J
Evaluation of new base-labile 2-(4-nitrophenylsulfonyl) ethoxycarbonyl (Nsc)-amino acids for solid-phase peptide synthesis.
The journal of peptide research : official journal of the American Peptide Society 2000;56(2):70-9.
2000: Ko M C; Willmont K J; Burritt A; Hruby V J; Woods J H
Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys.
European journal of pharmacology 2000;402(1-2):69-76.
2000: Witt K A; Slate C A; Egleton R D; Huber J D; Yamamura H I; Hruby V J; Davis T P
Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin.
Journal of neurochemistry 2000;75(1):424-35.
2000: Okayama T; Burritt A; Hruby V J
4-Alkoxy-2-hydroxybenzaldehyde (AHB): a versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics.
Organic letters 2000;2(13):1787-90.
2000: Bilsky E J; Egleton R D; Mitchell S A; Palian M M; Davis P; Huber J D; Jones H; Yamamura H I; Janders J; Davis T P; Porreca F; Hruby V J; Polt R
Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.
Journal of medicinal chemistry 2000;43(13):2586-90.
2000: Shenderovich M D; Liao S; Qian X; Hruby V J
A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands.
Biopolymers 2000;53(7):565-80.
2000: Trivedi D; Lin Y; Ahn J M; Siegel M; Mollova N N; Schram K H; Hruby V J
Design and synthesis of conformationally constrained glucagon analogues.
Journal of medicinal chemistry 2000;43(9):1714-22.
2000: Bilsky E J; Qian X; Hruby V J; Porreca F
Antinociceptive activity of [beta-methyl-2', 6'-dimethyltyrosine(1)]-substituted cyclic [D-Pen(2), D-Pen(5)]Enkephalin and [D-Ala(2),Asp(4)]Deltorphin analogs.
The Journal of pharmacology and experimental therapeutics 2000;293(1):151-8.
2000: Hosohata K; Logan J K; Varga E; Burkey T H; Vanderah T W; Porreca F; Hruby V J; Roeske W R; Yamamura H I
The role of the G protein gamma(2) subunit in opioid antinociception in mice.
European journal of pharmacology 2000;392(3):R9-R11.
2000: Soloshonok V A; Cai C; Hruby V J
(S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives.
Organic letters 2000;2(6):747-50.
2000: Bonner G G; Davis P; Stropova D; Edsall S; Yamamura H I; Porreca F; Hruby V J
Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays.
Journal of medicinal chemistry 2000;43(4):569-80.
2000: Hosohata Y; Vanderah T W; Burkey T H; Ossipov M H; Kovelowski C J; Sora I; Uhl G R; Zhang X; Rice K C; Roeske W R; Hruby V J; Yamamura H I; Lai J; Porreca F
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
European journal of pharmacology 2000;388(3):241-8.
2000: Okura T; Cowell S M; Varga E; Burkey T H; Roeske W R; Hruby V J; Yamamura H I
Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin.
European journal of pharmacology 2000;387(2):R11-3.
1999: Alfaro-Lopez J; Okayama T; Hosohata K; Davis P; Porreca F; Yamamura H I; Hruby V J
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.
Journal of medicinal chemistry 1999;42(26):5359-68.
1999: Kovelowski C J; Ossipov M H; Hruby V J; Porreca F
Lesions of the dorsolateral funiculus block supraspinal opioid delta receptor mediated antinociception in the rat.
Pain 1999;83(2):115-22.
1999: Tang Q; Gandhoke R; Burritt A; Hruby V J; Porreca F; Lai J
High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors.
The Journal of pharmacology and experimental therapeutics 1999;291(2):760-5.
1999: Kovelowski C J; Bian D; Hruby V J; Lai J; Ossipov M H; Porreca F
Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat.
Brain research 1999;843(1-2):12-7.
1999: Hosohata K; Burkey T H; Alfaro-Lopez J; Hruby V J; Roeske W R; Yamamura H I
(2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor.
European journal of pharmacology 1999;380(1):R9-10.
1999: Lipkowski A W; Misicka A; Davis P; Stropova D; Janders J; Lachwa M; Porreca F; Yamamura H I; Hruby V J
Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin.
Bioorganic & medicinal chemistry letters 1999;9(18):2763-6.
1999: Bartosz-Bechowski H; Davis P; Slaninova J; Malatynska E; Stropova D; Porreca F; Yamamura H I; Hruby V J
Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.
The journal of peptide research : official journal of the American Peptide Society 1999;53(3):329-36.
1999: Hruby V J; Agnes R S
Conformation-activity relationships of opioid peptides with selective activities at opioid receptors.
Biopolymers 1999;51(6):391-410.
1999: Gentry C L; Egleton R D; Gillespie T; Abbruscato T J; Bechowski H B; Hruby V J; Davis T P
The effect of halogenation on blood-brain barrier permeability of a novel peptide drug.
Peptides 1999;20(10):1229-38.
1998: Liao S; Alfaro-Lopez J; Shenderovich M D; Hosohata K; Lin J; Li X; Stropova D; Davis P; Jernigan K A; Porreca F; Yamamura H I; Hruby V J
De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.
Journal of medicinal chemistry 1998;41(24):4767-76.
1998: Nikiforovich G V; Sharma S D; Hadley M E; Hruby V J
Studies of conformational isomerism in alpha-melanocyte stimulating hormone by design of cyclic analogues.
Biopolymers 1998;46(3):155-67.
1998: Wessells H; Fuciarelli K; Hansen J; Hadley M E; Hruby V J; Dorr R; Levine N
Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.
The Journal of urology 1998;160(2):389-93.
1998: Sturm N S; Lin Y; Burley S K; Krstenansky J L; Ahn J M; Azizeh B Y; Trivedi D; Hruby V J
Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.
Journal of medicinal chemistry 1998;41(15):2693-700.
1998: al-Obeidi F; Hruby V J; Sawyer T K
Peptide and peptidomimetic libraries. Molecular diversity and drug design.
Molecular biotechnology 1998;9(3):205-23.
1998: Al-Obeidi F; O'Connor S D; Job C; Hruby V J; Pettitt B M
NMR and quenched molecular dynamics studies of superpotent linear and cyclic alpha-melanotropins.
The journal of peptide research : official journal of the American Peptide Society 1998;51(6):420-31.
1998: Alfaro-Lopez J; Yuan W; Phan B C; Kamath J; Lou Q; Lam K S; Hruby V J
Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design.
Journal of medicinal chemistry 1998;41(13):2252-60.
1998: Hosohata K; Burkey T H; Alfaro-Lopez J; Varga E; Hruby V J; Roeske W R; Yamamura H I
Endomorphin-1 and endomorphin-2 are partial agonists at the human mu-opioid receptor.
European journal of pharmacology 1998;346(1):111-4.
1998: Li G; Haq W; Xiang L; Lou B S; Hughes R; De Leon I A; Davis P; Gillespie T J; Romanowski M; Zhu X; Misicka A; Lipkowski A W; Porreca F; Davis T P; Yamamura H I; O'Brien D F; Hruby V J
Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.
Bioorganic & medicinal chemistry letters 1998;8(5):555-60.
1998: Vanderah T W; Raffa R B; Lashbrook J; Burritt A; Hruby V; Porreca F
Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats.
European journal of pain (London, England) 1998;2(3):267-78.
1998: Hadley M E; Hruby V J; Blanchard J; Dorr R T; Levine N; Dawson B V; al-Obeidi F; Sawyer T K
Discovery and development of novel melanogenic drugs. Melanotan-I and -II.
Pharmaceutical biotechnology 1998;11():575-95.
1998: Burkey T H; Ehlert F J; Hosohata Y; Quock R M; Cowell S; Hosohata K; Varga E; Stropova D; Li X; Slate C; Nagase H; Porreca F; Hruby V J; Roeske W R; Yamamura H I
The efficacy of delta-opioid receptor-selective drugs.
Life sciences 1998;62(17-18):1531-6.
1998: Slaninova J; Appleyard S M; Misicka A; Lipkowski A W; Knapp R J; Weber S J; Davis T P; Yamamura H I; Hruby V J
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.
Life sciences 1998;62(14):PL199-204.
1997: Hruby V J; Bartosz-Bechowski H; Davis P; Slaninova J; Zalewska T; Stropova D; Porreca F; Yamamura H I
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.
Journal of medicinal chemistry 1997;40(24):3957-62.
1997: Romanowski M; Zhu X; Ramaswami V; Misicka A; Lipkowski A W; Hruby V J; O'Brien D F
Interaction of a highly potent dimeric enkephalin analog, biphalin, with model membranes.
Biochimica et biophysica acta 1997;1329(2):245-58.
1997: Haaseth R C; Zalewska T; Davis P; Yamamura H I; Porreca F; Hruby V J
Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands.
The journal of peptide research : official journal of the American Peptide Society 1997;50(3):171-7.
1997: Abbruscato T J; Thomas S A; Hruby V J; Davis T P
Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry.
Journal of neurochemistry 1997;69(3):1236-45.
1997: Haskell-Luevano C; Toth K; Boteju L; Job C; Castrucci A M; Hadley M E; Hruby V J
beta-Methylation of the Phe7 and Trp9 melanotropin side chain pharmacophores affects ligand-receptor interactions and prolonged biological activity.
Journal of medicinal chemistry 1997;40(17):2740-9.
1997: Azizeh B Y; Ahn J M; Caspari R; Shenderovich M D; Trivedi D; Hruby V J
The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon.
Journal of medicinal chemistry 1997;40(16):2555-62.
1997: Misicka A; Cavagnero S; Horvath R; Davis P; Porreca F; Yamamura H I; Hruby V J
Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors.
The journal of peptide research : official journal of the American Peptide Society 1997;50(1):48-54.
1997: Haskell-Luevano C; Hendrata S; North C; Sawyer T K; Hadley M E; Hruby V J; Dickinson C; Gantz I
Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.
Journal of medicinal chemistry 1997;40(14):2133-9.
1997: Hruby V J; Ahn J M; Liao S
Synthesis of oligopeptide and peptidomimetic libraries.
Current opinion in chemical biology 1997;1(1):114-9.
1997: Quock R M; Hosohata Y; Knapp R J; Burkey T H; Hosohata K; Zhang X; Rice K C; Nagase H; Hruby V J; Porreca F; Roeske W R; Yamamura H I
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.
European journal of pharmacology 1997;326(1):101-4.
1997: Patel D; McKinley B D; Davis T P; Porreca F; Yamamura H I; Hruby V J
Peptide targeting and delivery across the blood-brain barrier utilizing synthetic triglyceride esters: design, synthesis, and bioactivity.
Bioconjugate chemistry 1997;8(3):434-41.
1997: Haskell-Luevano C; Nikiforovich G; Sharma S D; Yang Y K; Dickinson C; Hruby V J; Gantz I
Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Journal of medicinal chemistry 1997;40(11):1738-48.
1997: Thomas S A; Abbruscato T J; Hau V S; Gillespie T J; Zsigo J; Hruby V J; Davis T P
Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability.
The Journal of pharmacology and experimental therapeutics 1997;281(2):817-25.
1997: Sturm N S; Hutzler A M; David C S; Azizeh B Y; Trivedi D; Hruby V J
Structure-activity studies of hydrophobic amino acid replacements at positions 9, 11 and 16 of glucagon.
The journal of peptide research : official journal of the American Peptide Society 1997;49(4):293-9.
1997: Ugwu S O; Blanchard J; Dorr R T; Levine N; Brooks C; Hadley M E; Aickin M; Hruby V J
Skin pigmentation and pharmacokinetics of melanotan-I in humans.
Biopharmaceutics & drug disposition 1997;18(3):259-69.
1997: Castrucci A M; Almeida A L; al-Obeidi F A; Hadley M E; Hruby V J; Staples D J; Sawyer T K
Comparative biological activities of alpha-MSH antagonists in vertebrate pigment cells.
General and comparative endocrinology 1997;105(3):410-6.
1997: Thomas S A; Abbruscato T J; Hruby V J; Davis T P
The entry of [D-penicillamine2,5]enkephalin into the central nervous system: saturation kinetics and specificity.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1235-40.
1997: Jiang J; Sharma S D; Hruby V J; Fink J L; Hadley M E
Human epidermal melanocyte and keratinocyte melanotropin receptors: visualization by melanotropic peptide conjugated macrospheres (polyamide beads).
Experimental dermatology 1997;6(1):6-12.
1997: Abbruscato T J; Thomas S A; Hruby V J; Davis T P
Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: comparison with morphine.
The Journal of pharmacology and experimental therapeutics 1997;280(1):402-9.
1997: Hruby V J; Li G; Haskell-Luevano C; Shenderovich M
Design of peptides, proteins, and peptidomimetics in chi space.
Biopolymers 1997;43(3):219-66.
1997: Azizeh B Y; Van Tine B A; Trivedi D; Hruby V J
Pure glucagon antagonists: biological activities and cAMP accumulation using phosphodiesterase inhibitors.
Peptides 1997;18(5):633-41.
1997: Bonner G G; Davis P; Stropova D; Ferguson R; Yamamura H I; Porreca F; Hruby V J
Opioid peptides: simultaneous delta agonism and mu antagonism in somatostatin analogues.
Peptides 1997;18(1):93-100.
1997: Misicka A; Lipkowski A W; Horvath R; Davis P; Porreca F; Yamamura H I; Hruby V J
Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.
Life sciences 1997;60(15):1263-9.
1996: Bilsky E J; Inturrisi C E; Sadée W; Hruby V J; Porreca F
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.
Pain 1996;68(2-3):229-37.
1996: Jiang J; Sharma S D; Fink J L; Hadley M E; Hruby V J
Melanotropic peptide receptors: membrane markers of human melanoma cells.
Experimental dermatology 1996;5(6):325-33.
1996: Haskell-Luevano C; Sawyer T K; Trumpp-Kallmeyer S; Bikker J A; Humblet C; Gantz I; Hruby V J
Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists.
Drug design and discovery 1996;14(3):197-211.
1996: Varga E V; Li X; Stropova D; Zalewska T; Landsman R S; Knapp R J; Malatynska E; Kawai K; Mizusura A; Nagase H; Calderon S N; Rice K; Hruby V J; Roeske W R; Yamamura H I
The third extracellular loop of the human delta-opioid receptor determines the selectivity of delta-opioid agonists.
Molecular pharmacology 1996;50(6):1619-24.
1996: Sharma S D; Jiang J; Hadley M E; Bentley D L; Hruby V J
Melanotropic peptide-conjugated beads for microscopic visualization and characterization of melanoma melanotropin receptors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13715-20.
1996: Hruby V J; Shenderovich M; Lam K S; Lebl M
Design considerations and computer modeling related to the development of molecular scaffolds and peptide mimetics for combinatorial chemistry.
Molecular diversity 1996;2(1-2):46-56.
1996: Jiang J; Sharma S D; Hruby V J; Bentley D L; Fink J L; Hadley M E
Human epidermal melanocyte and keratinocyte melanocortin receptors: visualization by melanotropic peptide conjugated microspheres (latex beads).
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1996;9(5):240-7.
1996: Hadley M E; Hruby V J; Jiang J; Sharma S D; Fink J L; Haskell-Luevano C; Bentley D L; al-Obeidi F; Sawyer T K
Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1996;9(5):213-34.
1996: Boteju L W; Nikiforovich G V; Haskell-Luevano C; Fang S N; Zalewska T; Stropova D; Yamamura H I; Hruby V J
The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors.
Journal of medicinal chemistry 1996;39(20):4120-4.
1996: Malatynska E; Wang Y; Knapp R J; Waite S; Calderon S; Rice K; Hruby V J; Yamamura H I; Roeske W R
Human delta opioid receptor: functional studies on stably transfected Chinese hamster ovary cells after acute and chronic treatment with the selective nonpeptidic agonist SNC-80.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1083-9.
1996: Qian X; Liao S; Stropova D; Yamamura H I; Hruby V J
Novel scaffolds for non-peptide mimetics of delta opioid receptor agonists based on peptide leads.
Regulatory peptides 1996;65(1):79-82.
1996: Li S J; Varga K; Archer P; Hruby V J; Sharma S D; Kesterson R A; Cone R D; Kunos G
Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(16):5182-8.
1996: Van Tine B A; Azizeh B Y; Trivedi D; Phelps J R; Houslay M D; Johnson D G; Hruby V J
Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists.
Endocrinology 1996;137(8):3316-22.
1996: Ramaswami V; Zhu X; Romanowski M; Haaseth R C; Misicka A; Lipkowski A W; Hruby V J; O'Brien D F
Lipid membrane permeability of modified c[D-Pen2, D-Pen5]enkephalin peptides.
International journal of peptide and protein research 1996;48(1):87-94.
1996: Vanderah T W; Bernstein R N; Yamamura H I; Hruby V J; Porreca F
Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors.
The Journal of pharmacology and experimental therapeutics 1996;278(1):212-9.
1996: Lung F D; Meyer J P; Lou B S; Xiang L; Li G; Davis P; DeLeon I A; Yamamura H I; Porreca F; Hruby V J
Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.
Journal of medicinal chemistry 1996;39(13):2456-60.
1996: Azizeh B Y; Shenderovich M D; Trivedi D; Li G; Sturm N S; Hruby V J
Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences.
Journal of medicinal chemistry 1996;39(13):2449-55.
1996: Greene D L; Hau V S; Abbruscato T J; Bartosz H; Misicka A; Lipkowski A W; Hom S; Gillespie T J; Hruby V J; Davis T P
Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1366-75.
1996: Bilsky E J; Bernstein R N; Hruby V J; Rothman R B; Lai J; Porreca F
Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated "knock-down" of opioid receptor in vivo.
The Journal of pharmacology and experimental therapeutics 1996;277(1):491-501.
1996: Abbruscato T J; Williams S A; Misicka A; Lipkowski A W; Hruby V J; Davis T P
Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives.
The Journal of pharmacology and experimental therapeutics 1996;276(3):1049-57.
1996: Williams S A; Abbruscato T J; Hruby V J; Davis T P
Passage of a delta-opioid receptor selective enkephalin, [D-penicillamine2,5] enkephalin, across the blood-brain and the blood-cerebrospinal fluid barriers.
Journal of neurochemistry 1996;66(3):1289-99.
1996: Lung F D; Collins N; Stropova D; Davis P; Yamamura H I; Porreca F; Hruby V J
Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.
Journal of medicinal chemistry 1996;39(5):1136-41.
1996: Shenderovich M D; Kövér K E; Nikiforovich G V; Jiao D; Hruby V J
Conformational analysis of beta-methyl-para-nitrophenylalanine stereoisomers of cyclo[D-Pen2, D-Pen5]enkephalin by NMR spectroscopy and conformational energy calculations.
Biopolymers 1996;38(2):141-56.
1996: Haskell-Luevano C; Miwa H; Dickinson C; Hadley M E; Hruby V J; Yamada T; Gantz I
Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.
Journal of medicinal chemistry 1996;39(2):432-5.
1996: Haskell-Luevano C; Sawyer T K; Hendrata S; North C; Panahinia L; Stum M; Staples D J; Castrucci A M; Hadley M F; Hruby V J
Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity.
Peptides 1996;17(6):995-1002.
1996: Dorr R T; Lines R; Levine N; Brooks C; Xiang L; Hruby V J; Hadley M E
Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.
Life sciences 1996;58(20):1777-84.
1995: Jiang J; Sharma S D; Nakamura S; Lai J Y; Fink J L; Hruby V J; Hadley M E
The melanotropic peptide, [Nle4,D-Phe7] alpha-MSH, stimulates human melanoma tyrosinase activity and inhibits cell proliferation.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1995;8(6):314-23.
1995: Craft R M; Henley S R; Haaseth R C; Hruby V J; Porreca F
Opioid antinociception in a rat model of visceral pain: systemic versus local drug administration.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1535-42.
1995: Haskell-Luevano C; Boteju L W; Miwa H; Dickinson C; Gantz I; Yamada T; Hadley M E; Hruby V J
Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities.
Journal of medicinal chemistry 1995;38(23):4720-9.
1995: Knapp R J; Landsman R; Waite S; Malatynska E; Varga E; Haq W; Hruby V J; Roeske W R; Nagase H; Yamamura H I
Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors.
European journal of pharmacology 1995;291(2):129-34.
1995: Ossipov M H; Kovelowski C J; Nichols M L; Hruby V J; Porreca F
Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat.
Pain 1995;62(3):287-93.
1995: Kazmierski W M; Ferguson R D; Lipkowski A W; Hruby V J
A topographical model of mu-opioid and brain somatostatin receptor selective ligands. NMR and molecular dynamics studies.
International journal of peptide and protein research 1995;46(3-4):265-78.
1995: Meyer J P; Davis P; Lee K B; Porreca F; Yamamura H I; Hruby V J
Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1.
Journal of medicinal chemistry 1995;38(18):3462-8.
1995: Hruby V J; Lu D; Sharma S D; Castrucci A L; Kesterson R A; al-Obeidi F A; Hadley M E; Cone R D
Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.
Journal of medicinal chemistry 1995;38(18):3454-61.
1995: Haskell-Luevano C; Shenderovich M D; Sharma S D; Nikiforovich G V; Hadley M E; Hruby V J
Design, synthesis, biology, and conformations of bicyclic alpha-melanotropin analogues.
Journal of medicinal chemistry 1995;38(10):1736-50.
1995: Hruby V J; Yamamura H I; Porreca F
Molecular organization of receptors. Efficacy, agonists, and antagonists.
Annals of the New York Academy of Sciences 1995;757():7-22.
1995: Knapp R J; Malatynska E; Collins N; Fang L; Wang J Y; Hruby V J; Roeske W R; Yamamura H I
Molecular biology and pharmacology of cloned opioid receptors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(7):516-25.
1995: Bilsky E J; Calderon S N; Wang T; Bernstein R N; Davis P; Hruby V J; McNutt R W; Rothman R B; Rice K C; Porreca F
SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.
The Journal of pharmacology and experimental therapeutics 1995;273(1):359-66.
1995: Lung F D; Meyer J P; Li G; Lou B S; Stropova D; Davis P; Yamamura H I; Porreca F; Hruby V J
Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2.
Journal of medicinal chemistry 1995;38(4):585-6.
1995: Davis T P; Abbruscato T J; Brownson E; Hruby V J
Conformationally constrained peptide drugs targeted at the blood-brain barrier.
NIDA research monograph 1995;154():47-60.
1995: Meyer J P; Gillespie T J; Hom S; Hruby V J; Davis T P
In vitro stability of some reduced peptide bond pseudopeptide analogues of dynorphin A.
Peptides 1995;16(7):1215-9.
1995: Slaninova J; Knapp R J; Weber S J; Davis T P; Fang S N; Hruby V J; Yamamura H I
[125I]SNF 8702: a selective radioligand for CCKB receptors.
Peptides 1995;16(2):221-4.
1995: Misicka A; Lipkowski A W; Slaninova J; Davis P; Yamamura H I; Porreca F; Hruby V J
The synthesis and opioid receptor binding affinities of analogues of dermorphin and its N-terminal tetrapeptide fragment with dibasic acids in position 2.
Life sciences 1995;57(18):1633-40.
1994: Misicka A; Lipkowski A W; Horvath R; Davis P; Porreca F; Yamamura H I; Hruby V J
Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues.
International journal of peptide and protein research 1994;44(6):607.
1994: Haskell-Luevano C; Miwa H; Dickinson C; Hruby V J; Yamada T; Gantz I
Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.
Biochemical and biophysical research communications 1994;204(3):1137-42.
1994: Meyer J P; Collins N; Lung F D; Davis P; Zalewska T; Porreca F; Yamamura H I; Hruby V J
Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11.
Journal of medicinal chemistry 1994;37(23):3910-7.
1994: Johnson P D; Dawson B V; Dorr R T; Hadley M E; Levine N; Hruby V J
Coat color darkening in a dog in response to a potent melanotropic peptide.
American journal of veterinary research 1994;55(11):1593-6.
1994: Sharma S D; Granberry M E; Jiang J; Leong S P; Hadley M E; Hruby V J
Multivalent melanotropic peptide and fluorescent macromolecular conjugates: new reagents for characterization of melanotropin receptors.
Bioconjugate chemistry 1994;5(6):591-601.
1994: Knapp R J; Malatynska E; Peterson P; Zalewska T; Fang S; Hruby V J; Smith T L; Yamamura H I
[N-methylnorleucine-(28,31)]cholecystokinin-(26-33) (SNF 8702) activity at a cloned rat CCKB receptor.
European journal of pharmacology 1994;269(2):133-8.
1994: Collins N; Hruby V J
Prediction of the conformational requirements for binding to the kappa-opioid receptor and its subtypes. I. Novel alpha-helical cyclic peptides and their role in receptor selectivity.
Biopolymers 1994;34(9):1231-41.
1994: Lan E L; Ugwu S O; Blanchard J; Fang X; Hruby V J; Sharma S
Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide.
Journal of pharmaceutical sciences 1994;83(8):1081-4.
1994: Brownson E A; Abbruscato T J; Gillespie T J; Hruby V J; Davis T P
Effect of peptidases at the blood brain barrier on the permeability of enkephalin.
The Journal of pharmacology and experimental therapeutics 1994;270(2):675-80.
1994: Polt R; Porreca F; Szabò L Z; Bilsky E J; Davis P; Abbruscato T J; Davis T P; Harvath R; Yamamura H I; Hruby V J
Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7114-8.
1994: Misicka A; Lipkowski A W; Horvath R; Davis P; Porreca F; Yamamura H I; Hruby V J
Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues.
International journal of peptide and protein research 1994;44(1):80-4.
1994: Knapp R J; Malatynska E; Hashimoto S; Fang S; Hunt M; Wamsley J K; Peterson P; Zalewska T; Hruby V J; Yamamura H I
[3H]SNF8702 autoradiography of CCK-B receptors in guinea pig brain and studies with a cloned rat CCK-B receptor.
Annals of the New York Academy of Sciences 1994;713():380-3.
1994: Rao R K; Levenson S; Fang S N; Hruby V J; Yamamura H I; Porreca F
Role of substance P in the regulation of ion transport by CCKA and CCKB receptors in mouse ileum.
Annals of the New York Academy of Sciences 1994;713():420-1.
1994: Vanderah T; Takemori A E; Sultana M; Portoghese P S; Mosberg H I; Hruby V J; Haaseth R C; Matsunaga T O; Porreca F
Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo.
European journal of pharmacology 1994;252(2):133-7.
1994: Fang L; Knapp R J; Horvath R; Matsunaga T O; Haaseth R C; Hruby V J; Porreca F; Yamamura H I
Characterization of [3H]naltrindole binding to delta opioid receptors in mouse brain and mouse vas deferens: evidence for delta opioid receptor heterogeneity.
The Journal of pharmacology and experimental therapeutics 1994;268(2):836-46.
1994: Rao R K; Levenson S; Fang S N; Hruby V J; Yamamura H I; Porreca F
Characterization of SNF 9007, a novel cholecystokinin/opoid ligand in mouse ileum in vitro: evidence for involvement of cholecystokininA and cholecystokininB receptors in regulation of ion transport.
The Journal of pharmacology and experimental therapeutics 1994;268(2):1003-9.
1994: Bartosz-Bechowski H; Davis P; Zalewska T; Slaninova J; Porreca F; Yamamura H I; Hruby V J
Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.
Journal of medicinal chemistry 1994;37(1):146-50.
1994: Misicka A; Lipkowski A W; Horvath R; Davis P; Yamamura H I; Porreca F; Hruby V J
Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
Journal of medicinal chemistry 1994;37(1):141-5.
1994: Knapp R J; Malatynska E; Fang L; Li X; Babin E; Nguyen M; Santoro G; Varga E V; Hruby V J; Roeske W R
Identification of a human delta opioid receptor: cloning and expression.
Life sciences 1994;54(25):PL463-9.
1994: Bilsky E J; Bernstein R N; Pasternak G W; Hruby V J; Patel D; Porreca F; Lai J
Selective inhibition of [D-Ala2, Glu4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor.
Life sciences 1994;55(2):PL37-43.
1994: Hruby V J; Qian X
Approaches to the asymmetric synthesis of unusual amino acids.
Methods in molecular biology (Clifton, N.J.) 1994;35():249-86.
1994: Hruby V J; Bonner G G
Design of novel synthetic peptides including cyclic conformationally and topographically constrained analogs.
Methods in molecular biology (Clifton, N.J.) 1994;35():201-40.
1993: Matsunaga T O; Collins N; Ramaswami V; Yamamura S H; O'Brien D F; Hruby V J
Comparison of the membrane-bound states of two structurally similar delta-selective opioid peptides by transferred nuclear Overhauser effect spectroscopy and molecular modeling.
Biochemistry 1993;32(48):13180-9.
1993: Kawasaki A M; Knapp R J; Walton A; Wire W S; Zalewska T; Yamamura H I; Porreca F; Burks T F; Hruby V J
Syntheses, opioid binding affinities, and potencies of dynorphin A analogues substituted in positions, 1, 6, 7, 8 and 10.
International journal of peptide and protein research 1993;42(5):411-9.
1993: Vanderah T W; Wild K D; Takemori A E; Sultana M; Portoghese P S; Bowen W D; Hruby V J; Mosberg H I; Porreca F
Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors.
The Journal of pharmacology and experimental therapeutics 1993;267(1):449-55.
1993: Weber S J; Abbruscato T J; Brownson E A; Lipkowski A W; Polt R; Misicka A; Haaseth R C; Bartosz H; Hruby V J; Davis T P
Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1649-55.
1993: Horan P J; de Costa B R; Rice K; Haaseth R C; Hruby V J; Porreca F
Differential antagonism of bremazocine- and U69,593-induced antinociception by quadazocine: further functional evidence of opioid kappa receptor multiplicity in the mouse.
The Journal of pharmacology and experimental therapeutics 1993;266(2):926-33.
1993: Kramer T H; Davis P; Hruby V J; Burks T F; Porreca F
In vitro potency, affinity and agonist efficacy of highly selective delta opioid receptor ligands.
The Journal of pharmacology and experimental therapeutics 1993;266(2):577-84.
1993: Dharanipragada R; Trivedi D; Bannister A; Siegel M; Tourwe D; Mollova N; Schram K; Hruby V J
Synthetic linear and cyclic glucagon antagonists.
International journal of peptide and protein research 1993;42(1):68-77.
1993: Nikiforovich G V; Hruby V J
Models for the A- and B-receptor-bound conformations of CCK-8.
Biochemical and biophysical research communications 1993;194(1):9-16.
1993: Hruby V J
Conformational and topographical considerations in the design of biologically active peptides.
Biopolymers 1993;33(7):1073-82.
1993: Wild K D; Horan P J; Misicka A; Lipkowski A; Haaseth R C; Matsunaga T O; Hruby V J; Toth G; Borsodi A; Yamamura H I
Pseudoirreversible binding characteristics of [D-Ala2,Glu4]deltorphin and its Cys4 substituted derivative to delta-opioid receptors.
European journal of pharmacology 1993;246(1):25-31.
1993: Mollova N N; Schram K H; Lin Y; Dharanipragada R; Hruby V J
Characterization of linear and cyclic glucagon analogs by fast atom bombardment mass spectrometry.
Biological mass spectrometry 1993;22(5):267-76.
1993: Sawyer T K; Castrucci A M; Staples D J; Affholter J A; De Vaux A; Hruby V J; Hadley M E
Structure-activity relationships of [Nle4, D-Phe7]alpha-MSH. Discovery of a tripeptidyl agonist exhibiting sustained bioactivity.
Annals of the New York Academy of Sciences 1993;680():597-9.
1993: Hruby V J; Sharma S D; Toth K; Jaw J Y; al-Obeidi F; Sawyer T K; Hadley M E
Design, synthesis, and conformation of superpotent and prolonged acting melanotropins.
Annals of the New York Academy of Sciences 1993;680():51-63.
1993: Hadley M E; Sharma S D; Hruby V J; Levine N; Dorr R T
Melanotropic peptides for therapeutic and cosmetic tanning of the skin.
Annals of the New York Academy of Sciences 1993;680():424-39.
1993: Horan P J; Wild K D; Misicka A; Lipkowski A; Haaseth R C; Hruby V J; Weber S J; Davis T P; Yamamura H I; Porreca F
Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity.
The Journal of pharmacology and experimental therapeutics 1993;265(2):896-902.
1993: Nikiforovich G V; Prakash O M; Gehrig C A; Hruby V J
Solution conformations of the peptide backbone for DPDPE and its beta-MePhe4-substituted analogs.
International journal of peptide and protein research 1993;41(4):347-61.
1993: Horan P J; Wild K D; Kazmierski W M; Ferguson R; Hruby V J; Weber S J; Davis T P; Fang L; Knapp R J; Yamamura H I
Unexpected antinociceptive potency of cyclic [D-Tca1]CTAP: potential for a novel mechanism of action.
European journal of pharmacology 1993;233(1):53-62.
1993: Kawasaki A M; Knapp R J; Kramer T H; Walton A; Wire W S; Hashimoto S; Yamamura H I; Porreca F; Burks T F; Hruby V J
Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
Journal of medicinal chemistry 1993;36(6):750-7.
1993: Wild K D; Carlisi V J; Mosberg H I; Bowen W D; Portoghese P S; Sultana M; Takemori A E; Hruby V J; Porreca F
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens.
The Journal of pharmacology and experimental therapeutics 1993;264(2):831-8.
1993: Hruby V J; Gysin B; Trivedi D; Johnson D G
New glucagon analogues with conformational restrictions and altered amphiphilicity: effects on binding, adenylate cyclase and glycogenolytic activities.
Life sciences 1993;52(10):845-55.
1993: Hruby V J; Lam K S; Lebl M; Kazmierski W; Hersh E M; Salmon S E
Preparation of large peptide libraries with one peptide per bead and their use for the discovery of peptides that bind to acceptors.
NIDA research monograph 1993;134():75-83.
1992: Weber S J; Greene D L; Hruby V J; Yamamura H I; Porreca F; Davis T P
Whole body and brain distribution of [3H]cyclic [D-Pen2,D-Pen5] enkephalin after intraperitoneal, intravenous, oral and subcutaneous administration.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1308-16.
1992: Ramaswami V; Haaseth R C; Matsunaga T O; Hruby V J; O'Brien D F
Opioid peptide interactions with lipid bilayer membranes.
Biochimica et biophysica acta 1992;1109(2):195-202.
1992: Lebl M; Toth G; Slaninová J; Hruby V J
Conformationally biased analogs of oxytocin.
International journal of peptide and protein research 1992;40(2):148-51.
1992: Dharanipragada R; Bruck M; Hruby V J
The absolute configuration of an intermediate in the asymmetric synthesis of unusual amino acids.
Acta crystallographica. Section C, Crystal structure communications 1992;48 ( Pt 7)():1239-41.
1992: Toth G; Russell K C; Landis G; Kramer T H; Fang L; Knapp R; Davis P; Burks T F; Yamamura H I; Hruby V J
Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity.
Journal of medicinal chemistry 1992;35(13):2384-91.
1992: Smith D D; Slaninova J; Hruby V J
Structure-activity studies of a novel bicyclic oxytocin antagonist.
Journal of medicinal chemistry 1992;35(9):1558-63.
1992: Kazmierski W M; Ferguson R D; Knapp R J; Lui G K; Yamamura H I; Hruby V J
Reduced peptide bond cyclic somatostatin based opioid octapeptides. Synthesis, conformational properties and pharmacological characterization.
International journal of peptide and protein research 1992;39(5):401-14.
1992: al-Obeidi F; Hruby V J; Yaghoubi N; Marwan M M; Hadley M E
Synthesis and biological activities of fatty acid conjugates of a cyclic lactam alpha-melanotropin.
Journal of medicinal chemistry 1992;35(1):118-23.
1992: Matsunaga T O; Hruby V J; Lebl M; Castrucci A M; Hadley M E
Synthesis and bioactivity studies of two isosteric acyclic analogues of melanin concentrating hormone.
Life sciences 1992;51(9):679-85.
1992: Hruby V J
Strategies in the development of peptide antagonists.
Progress in brain research 1992;92():215-24.
1992: Fang L; Knapp R J; Matsunaga T; Weber S J; Davis T; Hruby V J; Yamamura H I
Synthesis of [D-Ala2,4'-125I-Phe3,Glu4]deltorphin and characterization of its delta opioid receptor binding properties.
Life sciences 1992;51(20):PL189-93.
1992: Misicka A; Lipkowski A W; Horvath R; Davis P; Kramer T H; Yamamura H I; Hruby V J
Topographical requirements for delta opioid ligands: common structural features of dermenkephalin and deltorphin.
Life sciences 1992;51(13):1025-32.
1992: Horan P; Tallarida R J; Haaseth R C; Matsunaga T O; Hruby V J; Porreca F
Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity.
Life sciences 1992;50(20):1535-41.
1992: Yamamura M S; Horvath R; Toth G; Otvos F; Malatynska E; Knapp R J; Porreca F; Hruby V J; Yamamura H I
Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain.
Life sciences 1992;50(16):PL119-24.
1991: Weber S J; Greene D L; Sharma S D; Yamamura H I; Kramer T H; Burks T F; Hruby V J; Hersh L B; Davis T P
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1109-17.
1991: Lebl M; Fang S A; Hruby V J
High-performance liquid chromatography of peptides at reduced temperatures: separation of isomers.
Journal of chromatography 1991;586(1):145-8.
1991: Misicka A; Lipkowski A W; Fang L; Knapp R J; Davis P; Kramer T; Burks T F; Yamamura H I; Carr D B; Hruby V J
Topographical requirements for delta opioid ligands: presence of a carboxyl group in position 4 is not critical for deltorphin high delta receptor affinity and analgesic activity.
Biochemical and biophysical research communications 1991;180(3):1290-7.
1991: Levine N; Sheftel S N; Eytan T; Dorr R T; Hadley M E; Weinrach J C; Ertl G A; Toth K; McGee D L; Hruby V J
Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin.
JAMA : the journal of the American Medical Association 1991;266(19):2730-6.
1991: Hadley M E; al-Obeidi F; Hruby V J; Weinrach J C; Freedberg D; Jiang J W; Stover R S
Biological activities of melanotropic peptide fatty acid conjugates.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1991;4(4):180-5.
1991: Zechel C; Trivedi D; Hruby V J
Synthetic glucagon antagonists and partial agonists.
International journal of peptide and protein research 1991;38(2):131-8.
1991: Nikiforovich G V; Hruby V J; Prakash O; Gehrig C A
Topographical requirements for delta-selective opioid peptides.
Biopolymers 1991;31(8):941-55.
1991: Slaninova J; Knapp R J; Wu J J; Fang S N; Kramer T; Burks T F; Hruby V J; Yamamura H I
Opioid receptor binding properties of analgesic analogues of cholecystokinin octapeptide.
European journal of pharmacology 1991;200(1):195-8.
1991: Hill P S; Chan W Y; Hruby V J
Oxytocin antagonists with changes in the Asn5 position shed light on hormone-oxytocin receptor interactions.
International journal of peptide and protein research 1991;38(1):32-7.
1991: Hruby V J; Toth G; Gehrig C A; Kao L F; Knapp R; Lui G K; Yamamura H I; Kramer T H; Davis P; Burks T F
Topographically designed analogues of [D-Pen,D-Pen5]enkephalin.
Journal of medicinal chemistry 1991;34(6):1823-30.
1991: Kramer T H; Toth G; Haaseth R C; Matsunaga T O; Davis P; Hruby V J; Burks T F
Influence of peptidase inhibitors on the apparent agonist potency of delta selective opioid peptides in vitro.
Life sciences 1991;48(9):881-6.
1991: Ayres E A; Parkhurst D N; Fang S; Kramer T H; Hruby V J; Burks T F
Antinociceptive and gastrointestinal transit effects of cholecystokinin (CCK-8) and related analogs of CCK-8 in the mouse.
Proceedings of the Western Pharmacology Society 1991;34():477-84.
1991: Wire W S; Fang S N; Hruby V J; Finch S T; Kramer T H; Burks T F
The effects of a centrally selective cholecystokinin analog on male, Sprague Dawley rats in the non-fasted food intake model.
Proceedings of the Western Pharmacology Society 1991;34():453-9.
1991: Hruby V J; Prakash O; Kazmierski W; Gehrig C; Matsunaga T O
Conformational analysis of opioid receptor-selective peptides using nuclear magnetic resonance and theoretical calculations.
NIDA research monograph 1991;112():198-217.
1991: Cavagnero S; Misicka A; Knapp R J; Davis P; Fang L; Burks T F; Yamamura H I; Hruby V J
Delta opioid receptor-selective ligands: [D-Pen2,D-Pen5]enkephalin-dermenkephalin chimeric peptides.
Life sciences 1991;49(7):495-503.
1990: Knapp R J; Vaughn L K; Fang S N; Bogert C L; Yamamura M S; Hruby V J; Yamamura H I
A new, highly selective CCK-B receptor radioligand ([3H][N-methyl-Nle28,31]CCK26-33): evidence for CCK-B receptor heterogeneity.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1278-86.
1990: Nikiforovich G V; Hruby V J
Examination of the conformational meaning of "delta-address" in the dermenkephalin sequence.
Biochemical and biophysical research communications 1990;173(2):521-7.
1990: Lebl M; Hill P; Kazmierski W; Kárászová L; Slaninová J; Fric I; Hruby V J
Conformationally restricted analogs of oxytocin; stabilization of inhibitory conformation.
International journal of peptide and protein research 1990;36(4):321-30.
1990: Benson B; Ebels I; Hruby V J
Isolation and structure elucidation of bovine pineal arginine vasopressin: arginine vasotocin not identified.
International journal of peptide and protein research 1990;36(2):109-21.
1990: Kawasaki A M; Knapp R J; Kramer T H; Wire W S; Vasquez O S; Yamamura H I; Burks T F; Hruby V J
Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
Journal of medicinal chemistry 1990;33(7):1874-9.
1990: Hruby V J; Fang S A; Knapp R; Kazmierski W; Lui G K; Yamamura H I
Cholecystokinin analogues with high affinity and selectivity for brain membrane receptors.
International journal of peptide and protein research 1990;35(6):566-73.
1990: al-Obeidi F; Mulcahy M; Pitt V S; Begay V; Hadley M E; Hruby V J
Synthesis and actions of a melanotropin conjugate, Ac-[Nle4, Glu(gamma-4'-hydroxyanilide)5, D-Phe7]alpha-MSH4-10-NH2, on melanocytes and melanoma cells in vitro.
Journal of pharmaceutical sciences 1990;79(6):500-4.
1990: Hruby V J; al-Obeidi F; Kazmierski W
Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations.
The Biochemical journal 1990;268(2):249-62.
1990: Dawson B V; Hadley M E; Levine N; Kreutzfeld K L; Don S; Eytan T; Hruby V J
In vitro transdermal delivery of a melanotropic peptide through human skin.
The Journal of investigative dermatology 1990;94(4):432-5.
1990: al-Obeidi F; Hruby V J; Hadley M E; Sawyer T K; Castrucci A M
Design, synthesis, and biological activities of a potent and selective alpha-melanotropin antagonist.
International journal of peptide and protein research 1990;35(3):228-34.
1990: al-Obeidi F; Sanderson D G; Hruby V J
Synthesis of beta- and gamma-fluorenylmethyl esters of respectively N alpha-Boc-L-aspartic acid and N alpha-Boc-L-glutamic acid.
International journal of peptide and protein research 1990;35(3):215-8.
1990: Fric I; Hlavacek J; Rockway T W; Chan W Y; Hruby V J
Effects of conformational constraint in 2- and 8-cycloleucine analogues of oxytocin and [1-penicillamine] oxytocin examined by circular dichroism and bioassay.
Journal of protein chemistry 1990;9(1):9-15.
1990: Spencer R L; Hruby V J; Burks T F
Alteration of thermoregulatory set point with opioid agonists.
The Journal of pharmacology and experimental therapeutics 1990;252(2):696-705.
1990: Vaughn L K; Wire W S; Davis P; Shimohigashi Y; Toth G; Knapp R J; Hruby V J; Burks T F; Yamamura H I
Differentiation between rat brain and mouse vas deferens delta opioid receptors.
European journal of pharmacology 1990;177(1-2):99-101.
1990: Toth G; Kramer T H; Knapp R; Lui G; Davis P; Burks T F; Yamamura H I; Hruby V J
[D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors.
Journal of medicinal chemistry 1990;33(1):249-53.
1990: Wire W S; Fang S N; Hruby V J; Farmer S C; Riviere P; Kramer T H; Burks T F
Evaluation of a food intake model as a tool for studying cholecystokinin (CCK) and derivatives of CCK in male Sprague-Dawley rats.
Proceedings of the Western Pharmacology Society 1990;33():65-8.
1990: Hruby V J; Chow M S; Smith D D
Conformational and structural considerations in oxytocin-receptor binding and biological activity.
Annual review of pharmacology and toxicology 1990;30():501-34.
1990: Kramer T H; Toth G; Ayres E A; Hruby V J; Burks T F
Antinociceptive actions of novel delta opioid receptor agonists in the mouse.
Progress in clinical and biological research 1990;328():473-6.
1990: Matsunaga T O; Gehrig C A; Hruby V J
1H-NMR assignments and conformational studies of melanin concentrating hormone in water using two-dimensional NMR.
Biopolymers 1990;30(13-14):1291-5.
1990: Gehrig C A; Prakash O; Toth G; Hruby V J
Design and synthesis of opioid receptor selective enkephalin analogues.
NIDA research monograph 1990;105():378-9.
1989: Al-Obeidi F; Castrucci A M; Hadley M E; Hruby V J
Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
Journal of medicinal chemistry 1989;32(12):2555-61.
1989: Wynants C; Tourwe D; Kazmierski W; Hruby V J; Van Binst G
Conformation of two somatostatin analogues in aqueous solution. Study by NMR methods and circular dichroism.
European journal of biochemistry / FEBS 1989;185(2):371-81.
1989: Hadley M E; Marwan M M; al-Obeidi F; Hruby V J; Castrucci A M
Linear and cyclic alpha-melanotropin [4-10]-fragment analogues that exhibit superpotency and residual activity.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(6):478-84.
1989: Matsunaga T O; Hruby V J; Lebl M; Castrucci A M; Hadley M E
Melanin concentrating hormone (MCH): structure-function aspects of its melanocyte stimulating hormone-like (MSH-like) activity.
Peptides 1989;10(4):773-8.
1989: Hruby V J; Gehrig C A
Recent developments in the design of receptor specific opioid peptides.
Medicinal research reviews 1989;9(3):343-401.
1989: Kramer T H; Shook J E; Kazmierski W; Ayres E A; Wire W S; Hruby V J; Burks T F
Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 1989;249(2):544-51.
1989: Shook J E; Lemcke P K; Gehrig C A; Hruby V J; Burks T F
Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.
The Journal of pharmacology and experimental therapeutics 1989;249(1):83-90.
1989: Matsunaga T O; Castrucci A M; Hadley M E; Hruby V J
Melanin concentrating hormone (MCH): synthesis and bioactivity studies of MCH fragment analogues.
Peptides 1989;10(2):349-54.
1989: Beckwith B E; Tinius T P; Hruby V J; al-Obeidi F; Sawyer T K; Affholter J A
The effects of structure-conformation modifications of melanotropin analogs on learning and memory: D-amino acid substituted linear and cyclic analogs.
Peptides 1989;10(2):361-8.
1989: Landis G; Lui G; Shook J E; Yamamura H I; Burks T F; Hruby V J
Synthesis of highly mu and delta opioid receptor selective peptides containing a photoaffinity group.
Journal of medicinal chemistry 1989;32(3):638-43.
1989: Hawkins K N; Knapp R J; Lui G K; Gulya K; Kazmierski W; Wan Y P; Pelton J T; Hruby V J; Yamamura H I
[3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain.
The Journal of pharmacology and experimental therapeutics 1989;248(1):73-80.
1989: Al-Obeidi F; Hruby V J; Castrucci A M; Hadley M E
Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10.
Journal of medicinal chemistry 1989;32(1):174-9.
1989: Castrucci A M; Lebl M; Hruby V J; Matsunaga T O; Hadley M E
Melanin concentrating hormone. III. Melanin concentrating hormone (MCH): the message sequence.
Life sciences 1989;45(13):1141-8.
1989: Lebl M; Hruby V J; Castrucci A M; Hadley M E
Melanin concentrating hormone analogues: contraction of the cyclic structure. II. Antagonist activity.
Life sciences 1989;44(7):451-7.
1989: Burks T F; Kramer T H; Davis P; Toth G; Hruby V J
Novel [D-Pen2, D-Pen5]enkephalin derivatives with increased sigma receptor potency and selectivity: potential tools for opioid pharmacology.
NIDA research monograph 1989;95():291-2.
1989: Hruby V J
Designing molecules: specific peptides for specific receptors.
Epilepsia 1989;30 Suppl 1():S42-50; discussion S64-8.
1989: Vaughn L K; Knapp R J; Toth G; Wan Y P; Hruby V J; Yamamura H I
A high affinity, highly selective ligand for the delta opioid receptor: [3H]-[D-Pen2, pCl-Phe4, d-Pen5]enkephalin.
Life sciences 1989;45(11):1001-8.
1989: Ayres E A; Lemcke P K; Kramer T H; Toth G; Hruby V J; Burks T F
A comparison among antinociceptive bioassays for mu and delta agonists.
Proceedings of the Western Pharmacology Society 1989;32():167-71.
1988: Krstenansky J L; Zechel C; Trivedi D; Hruby V J
Importance of the C-terminal alpha-helical structure for glucagon's biological activity.
International journal of peptide and protein research 1988;32(6):468-75.
1988: Dorr R T; Dawson B V; al-Obeidi F; Hadley M E; Levine N; Hruby V J
Toxicologic studies of a superpotent alpha-melanotropin, [Nle4, D-Phe7]alpha-MSH.
Investigational new drugs 1988;6(4):251-8.
1988: Kazmierski W; Wire W S; Lui G K; Knapp R J; Shook J E; Burks T F; Yamamura H I; Hruby V J
Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors.
Journal of medicinal chemistry 1988;31(11):2170-7.
1988: Sugg E E; Castrucci A M; Hadley M E; van Binst G; Hruby V J
Cyclic lactam analogues of Ac-[Nle4]alpha-MSH4-11-NH2.
Biochemistry 1988;27(21):8181-8.
1988: Shook J E; Kazmierski W; Wire W S; Lemcke P K; Hruby V J; Burks T F
Opioid receptor selectivity of beta-endorphin in vitro and in vivo: mu, delta and epsilon receptors.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1018-25.
1988: McKee R L; Hruby V J; Trivedi D B; Johnson D G; Gandolfi A J; Krumdieck C L; Brendel K
Perifused precision-cut liver slice system for the study of hormone-regulated hepatic glucose metabolism.
Journal of pharmacological methods 1988;19(4):339-54.
1988: Spencer R L; Hruby V J; Burks T F
Body temperature response profiles for selective mu, delta and kappa opioid agonists in restrained and unrestrained rats.
The Journal of pharmacology and experimental therapeutics 1988;246(1):92-101.
1988: Sugg E E; Serra M; Shook J E; Yamamura H I; Burks T F; Korc M; Hruby V J
Cholecystokinic activity of N alpha-hydroxysulfonyl-[Nle28,31]CCK26-33 analogues modified at the C-terminal residue.
International journal of peptide and protein research 1988;31(6):514-9.
1988: Lebl M; Hruby V J; Castrucci A M; Visconti M A; Hadley M E
Melanin concentrating hormone analogues: contraction of the cyclic structure. 1. Agonist activity.
Journal of medicinal chemistry 1988;31(5):949-54.
1988: Hruby V J
In memoriam Choh Hao Li, April 21, 1913-November 28, 1987.
International journal of peptide and protein research 1988;31(3):253-4.
1988: Sugg E E; Tourwe D; Kazmierski W; Hruby V J; Van Binst G
Proton n.m.r. investigation of conformational influence of penicillamine residues on the disulfide ring system of opioid receptor selective somatostatin derivatives.
International journal of peptide and protein research 1988;31(2):192-200.
1988: Hadley M E; Castrucci A M; Hruby V J
Melanin concentrating hormone (MCH) mechanisms of action.
Progress in clinical and biological research 1988;256():531-45.
1988: Ayres E A; Villar R; Kramer T H; Kazmierski W; Hruby V J; Burks T F
Highly selective mu opioid antagonist peptides block spinal mu opioid inhibition of gastrointestinal transit.
Proceedings of the Western Pharmacology Society 1988;31():41-3.
1988: Shook J; Kazmierski W; Hruby V; Burks T
Precipitation of spinally mediated withdrawal signs by intrathecal administration of naloxone and the mu-receptor antagonist CTP in morphine-dependent mice.
NIDA research monograph 1988;81():143-8.
1988: Hawkins K N; Knapp R J; Gehlert D R; Lui G K; Yamamura M S; Roeske L C; Hruby V J; Yamamura H I
Quantitative autoradiography of [3H]CTOP binding to mu opioid receptors in rat brain.
Life sciences 1988;42(25):2541-51.
1988: Dawson B V; Hadley M E; Kreutzfeld K; Dorr R T; Hruby V J; Al-Obeidi F; Don S
Transdermal delivery of a melanotropic peptide hormone analogue.
Life sciences 1988;43(14):1111-7.
1988: Landis G C; Eckman D; Hruby V J; Kreulen D L
Temperature dependence of the effect of tachykinins on whole guinea-pig ileum in vitro.
Proceedings of the Western Pharmacology Society 1988;31():29-32.
1987: Shook J E; Pelton J T; Hruby V J; Burks T F
Peptide opioid antagonist separates peripheral and central opioid antitransit effects.
The Journal of pharmacology and experimental therapeutics 1987;243(2):492-500.
1987: Grady T; Fickova M; Tager H S; Trivedi D; Hruby V J
Stimulation and inhibition of cAMP accumulation by glucagon in canine hepatocytes.
The Journal of biological chemistry 1987;262(32):15514-20.
1987: Hagopian W A; Tager H S; Gysin B; Trivedi D; Hruby V J
Interactions of glucagon and glucagon analogs with isolated canine hepatocytes.
The Journal of biological chemistry 1987;262(32):15506-13.
1987: Hruby V J; Wilkes B C; Hadley M E; Al-Obeidi F; Sawyer T K; Staples D J; de Vaux A E; Dym O; Castrucci A M; Hintz M F
alpha-Melanotropin: the minimal active sequence in the frog skin bioassay.
Journal of medicinal chemistry 1987;30(11):2126-30.
1987: Wynants C; Sugg E; Hruby V J; Van Binst G
Conformational study of a somatostatin analogue by high-field n.m.r. spectroscopy, in aqueous solution.
International journal of peptide and protein research 1987;30(4):541-7.
1987: Lebl M; Sugg E E; van Binst G; Vander Elst P; Tourwé D; Slaninová J; Hruby V J
Analogs of oxytocin containing a modified peptide bond.
International journal of peptide and protein research 1987;30(3):318-22.
1987: Barth T; Slaninová J; Lebl M; Hruby V J
Effect of threonine in position 4 in oxytocin and vasotocin analogs on the time course of uterotonic response.
Endocrinologia experimentalis 1987;21(3):191-7.
1987: Gysin B; Johnson D G; Trivedi D; Hruby V J
Synthesis of two glucagon antagonists: receptor binding, adenylate cyclase, and effects on blood plasma glucose levels.
Journal of medicinal chemistry 1987;30(8):1409-15.
1987: Shook J E; Pelton J T; Lemcke P K; Porreca F; Hruby V J; Burks T F
Mu opioid antagonist properties of a cyclic somatostatin octapeptide in vivo: identification of mu receptor-related functions.
The Journal of pharmacology and experimental therapeutics 1987;242(1):1-7.
1987: Shook J E; Pelton J T; Wire W S; Hirning L D; Hruby V J; Burks T F
Pharmacologic evaluation of a cyclic somatostatin analog with antagonist activity at mu opioid receptors in vitro.
The Journal of pharmacology and experimental therapeutics 1987;240(3):772-7.
1987: Lebl M; Sugg E E; Hruby V J
Proton n.m.r. spectroscopic evidence for sulfur-aromatic interactions in peptides.
International journal of peptide and protein research 1987;29(1):40-5.
1987: Lemcke P K; Sugg E; Malarchik M; Lui G; Serra M; Yamamura H I; Hruby V J; Shook J E; Burks T F
N-terminal cyclization of a nonsulfated CCK analogue exhibits opioid antagonist activity in vitro.
Proceedings of the Western Pharmacology Society 1987;30():223-6.
1987: Brendel K; McKee R L; Hruby V J; Johnson D G; Gandolfi A J; Krumdieck C L
Precision cut tissue slices in culture: a new tool in pharmacology.
Proceedings of the Western Pharmacology Society 1987;30():291-3.
1987: Shook J E; Pelton J T; Kazmierski W; Lemcke P K; Villar R G; Hruby V J; Burks T F
A cyclic somatostatin analog that precipitates withdrawal in morphine-dependent mice.
NIDA research monograph 1987;76():295-301.
1987: Wire W S; Pelton J T; Kazmierski W; Hruby V J; Burks T F; Shook J E
Structure-activity analysis of five constrained somatostatin like peptides with opioid antagonist properties.
Proceedings of the Western Pharmacology Society 1987;30():237-41.
1987: Landis G C; Eckman D R; Hruby V J; Kreulen D L
A time dose-response desensitization study of substance P in the guinea-pig ileum.
Proceedings of the Western Pharmacology Society 1987;30():163-5.
1986: Gysin B; Trivedi D; Johnson D G; Hruby V J
Design and synthesis of glucagon partial agonists and antagonists.
Biochemistry 1986;25(25):8278-84.
1986: Smith P F; Krack G; McKee R L; Johnson D G; Gandolfi A J; Hruby V J; Krumdieck C L; Brendel K
Maintenance of adult rat liver slices in dynamic organ culture.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1986;22(12):706-12.
1986: Pelton J T; Kazmierski W; Gulya K; Yamamura H I; Hruby V J
Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors.
Journal of medicinal chemistry 1986;29(11):2370-5.
1986: Sugg E E; Shook J E; Serra M; Korc M; Yamamura H I; Burks T F; Hruby V J
Synthesis and biological evaluation of N alpha-hydroxysulfonyl-[Nle28,31]-CCK26-33.
Life sciences 1986;39(18):1623-9.
1986: Krstenansky J L; Trivedi D; Hruby V J
Importance of the 10-13 region of glucagon for its receptor interactions and activation of adenylate cyclase.
Biochemistry 1986;25(13):3833-9.
1986: Klemes D G; Kreutzfeld K L; Hadley M E; Cody W L; Hruby V J
Potent and prolonged melanotropic activities of the alpha-MSH fragment analog, Ac-[Nle4,D-Phe7]-alpha-MSH4-9-NH2.
Biochemical and biophysical research communications 1986;137(2):722-8.
1986: Gulya K; Pelton J T; Hruby V J; Yamamura H I
Cyclic somatostatin octapeptide analogues with high affinity and selectivity toward mu opioid receptors.
Life sciences 1986;38(24):2221-9.
1986: Abdel Malek Z A; Hadley M E; Bregman M D; Meyskens F L; Hruby V J
Actions of melanotropins on mouse melanoma cell growth in vitro.
Journal of the National Cancer Institute 1986;76(5):857-63.
1986: Abdel Malek Z A; Kreutzfeld K L; Hadley M E; Bregman M D; Hruby V J; Meyskens F L
Long-term and residual melanotropin-stimulated tyrosinase activity in S91 melanoma cells is density dependent.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1986;22(2):75-81.
1986: Hruby V J; Krstenansky J; Gysin B; Pelton J T; Trivedi D; Mckee R L
Conformational considerations in the design of glucagon agonists and antagonists: examination using synthetic analogs.
Biopolymers 1986;25 Suppl():S135-55.
1986: Gulya K; Lui G K; Pelton J T; Kazmierski W; Hruby V J; Yamamura H I
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2: a potent and selective antagonist opioid receptors.
NIDA research monograph 1986;75():209-12.
1986: Shook J E; Pelton J T; Kazmierski W; Lemcke P K; Wire W S; Hruby V J; Burks T F
Comparison of the opioid antagonist properties of a cyclic somatostatin analog in vitro and in vivo.
NIDA research monograph 1986;75():205-8.
1985: Abdel Malek Z A; Kreutzfeld K L; Marwan M M; Hadley M E; Hruby V J; Wilkes B C
Prolonged stimulation of S91 melanoma tyrosinase by [Nle4, D-Phe7]-substituted alpha-melanotropins.
Cancer research 1985;45(10):4735-40.
1985: Gulya K; Wamsley J K; Gehlert D; Pelton J T; Duckles S P; Hruby V J; Yamamura H I
Light microscopic autoradiographic localization of somatostatin receptors in the rat brain.
The Journal of pharmacology and experimental therapeutics 1985;235(1):254-8.
1985: Marwan M M; Abdel Malek Z A; Kreutzfeld K L; Hadley M E; Wilkes B C; Hruby V J; Castrucci A M
Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins.
Molecular and cellular endocrinology 1985;41(2-3):171-7.
1985: Chaturvedi D N; Hruby V J; Castrucci A M; Kreutzfeld K L; Hadley M E
Synthesis and biological evaluation of the superagonist [N alpha-chlorotriazinylaminofluorescein-Ser1,Nle4,D-Phe7]-al pha-MSH.
Journal of pharmaceutical sciences 1985;74(3):237-40.
1985: Pelton J T; Gulya K; Hruby V J; Duckles S P; Yamamura H I
Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(1):236-9.
1985: Hadley M E; Abdel Malek Z A; Marwan M M; Kreutzfeld K L; Hruby V J
[Nle4, D-Phe7]-alpha-MSH: a superpotent melanotropin that "irreversibly" activates melanoma tyrosinase.
Endocrine research 1985;11(3-4):157-70.
1985: Peterson L J; Hirning L D; Pelton J T; Hruby V J; Burks T F
A comparison of the opioid antagonist properties of novel somatostatin analogs in vitro.
Proceedings of the Western Pharmacology Society 1985;28():165-7.
1985: Pelton J T; Gulya K; Hruby V J; Duckles S; Yamamura H I
Somatostatin analogs with affinity for opiate receptors in rat brain binding assay.
Peptides 1985;6 Suppl 1():159-63.

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