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Frank Porreca

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Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Edita Navratilova; Tamara King; Jennifer Y Xie; Frank Porreca
Evaluation of reward from pain relief.
Alysia N Lozano-Ondoua; Patrick W Mantyh; Mark A Nelson; Tijana Nikolich-Zugich; Mabel Owusu-Ankomah; Frank Porreca; Ashley M Symons-Liguori; Aaron P Bloom; Anupama Chandramouli; Henry L Ferland; Katherine E Hanlon; Josh J Havelin; Juan Miguel Jimenez-Andrade; Tamara King; Tally M Largent-Milnes; Todd W Vanderah
Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.

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All Publications

2013: Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Bioorganic & medicinal chemistry letters 2013;23(11):3434-7.
2013: Edita Navratilova; Tamara King; Jennifer Y Xie; Frank Porreca
Evaluation of reward from pain relief.
Annals of the New York Academy of Sciences 2013;1282(1):1-11.
2013: Alysia N Lozano-Ondoua; Patrick W Mantyh; Mark A Nelson; Tijana Nikolich-Zugich; Mabel Owusu-Ankomah; Frank Porreca; Ashley M Symons-Liguori; Aaron P Bloom; Anupama Chandramouli; Henry L Ferland; Katherine E Hanlon; Josh J Havelin; Juan Miguel Jimenez-Andrade; Tamara King; Tally M Largent-Milnes; Todd W Vanderah
Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(1):92-107.
2012: Edita Navratilova; Alec Okun; Michael H Ossipov; Shuang Ci; Nathan Eyde; Howard L Fields; Tamara King; Chaoling Qu; Jennifer Y Xie; Frank Porreca
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):20709-13.
2012: Frank Porreca
Holiday message from Life Sciences.
Life sciences 2012;91(23-24):1139.
2012: Rebecca Edelmayer; Pierangelo Geppetti; Larry N Le; Serena Materazzi; Romina Nassini; Frank Porreca; Delia Preti; Todd W Vanderah; Xiaomei Wei; Jin Yan; Giovanni Appendino; David W Dodick; G Dussor
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.
Pain 2012;153(9):1949-58.
2012: Milena De Felice; Pietro Melchiorri; Michael H Ossipov; Frank Porreca; Todd W Vanderah; Lucia Negri
Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression.
Neuroscience letters 2012;521(1):40-5.
2012: Tamara King; Edward K Mandell; Irina Y Maskaykina; Ohannes K Melemedjian; Edita Navratilova; Alec Okun; G Dussor; Sourav Ghosh; Theodore Price; Chaoling Qu; Frank Porreca
Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain.
Pain 2012;153(6):1263-73.
2012: Alec Okun; Michael H Ossipov; Bethany Remeniuk; Jiyang Ren; Jennifer Xie; Triza Brion; Peg Davis; G Dussor; Tamara King; Ping Liu; Frank Porreca
Afferent drive elicits ongoing pain in a model of advanced osteoarthritis.
Pain 2012;153(4):924-33.
2012: Rebecca Edelmayer; Michael H Ossipov; Frank Porreca
An experimental model of headache-related pain.
Methods in molecular biology (Clifton, N.J.) 2012;851():109-20.
2011: Milena De Felice; G Dussor; Howard L Fields; Tamara King; Josephine Lai; Michael H Ossipov; Janice Oyarzo; Theodore Price; Raul Sanoja; Todd W Vanderah; Louis Vera-Portocarrero; Ruizhong Wang; Frank Porreca
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain.
Pain 2011;152(12):2701-9.
2011: Ruben Vardanyan; Eva Varga; Peg Davis; Vlad K Kumirov; Josephine Lai; Erika Liktor-Busa; Gary S Nichol; Frank Porreca; David Rankin; Todd W Vanderah; Victor J Hruby
Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.
Bioorganic & medicinal chemistry 2011;19(20):6135-42.
2011: Xu Yue; Leslie A Zuniga; Lajos Szabò; Torsten Falk; Robin Polt; Frank Porreca; Scott J Sherman
Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease.
Brain research 2011;1413():72-83.
2011: Tamara King; Josephine Lai; Ramon Mercado; Alec Okun; Chaoling Qu; Jiyang Ren; Triza Brion; Frank Porreca
Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity.
Pain 2011;152(9):1997-2005.
2011: Beatriz Fioravanti; Edward D French; Jed A Hartings; Aimen Kasasbeh; Frank Porreca; David P Skinner; Ryan D Burklund; Milena De Felice; David W Dodick; G Dussor; Rebecca Edelmayer; Todd W Vanderah
Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats.
Cephalalgia : an international journal of headache 2011;31(10):1090-100.
2011: Chaoling Qu; Howard L Fields; Tamara King; Josephine Lai; Alec Okun; Frank Porreca
Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy.
Pain 2011;152(7):1641-8.
2011: Katherine E Hanlon; Dave S Herman; Richard S Agnes; Tally M Largent-Milnes; Isuru R Kumarasinghe; Shou-wu Ma; Wenhong Guo; Yeon-Sun Lee; Michael H Ossipov; Victor J Hruby; Josephine Lai; Frank Porreca; Todd W Vanderah
Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.
Brain research 2011;1395():1-11.
2011: Milena De Felice; Michael H Ossipov; Frank Porreca
Persistent medication-induced neural adaptations, descending facilitation, and medication overuse headache.
Current opinion in neurology 2011;24(3):193-6.
2011: Louis P Vera-Portocarrero; Tamara King; Josephine Lai; Michael H Ossipov; Frank Porreca
Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats.
The journal of pain : official journal of the American Pain Society 2011;12(6):667-76.
2011: Marina N Asiedu; Dipti V Tillu; Ohannes K Melemedjian; Adia Shy; Raul Sanoja; Bryce Bodell; Sourav Ghosh; Frank Porreca; Theodore J Price
Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(18):6646-53.
2011: Ian D Meng; David Dodick; Michael H Ossipov; Frank Porreca
Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies.
Cephalalgia : an international journal of headache 2011;31(7):851-60.
2011: Ping Liu; Alec Okun; Jiyang Ren; Rui-Chen Guo; Michael H Ossipov; Jennifer Xie; Tamara King; Frank Porreca
Ongoing pain in the MIA model of osteoarthritis.
Neuroscience letters 2011;493(3):72-5.
2011: Takashi Yamamoto; Padma Nair; Tally M Largent-Milnes; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Journal of medicinal chemistry 2011;54(7):2029-38.
2011: Nicola J Stagg; Heriberto P Mata; Mohab M Ibrahim; Erik J Henriksen; Frank Porreca; Todd W Vanderah; T Philip Malan
Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids.
Anesthesiology 2011;114(4):940-8.
2011: Milena De Felice; Michael H Ossipov; Frank Porreca
Update on medication-overuse headache.
Current pain and headache reports 2011;15(1):79-83.
2011: Yeon Sun Lee; Shou-wu Ma; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Scott M Cowell; Peg Davis; Katherine E Hanlon; Vinod Kulkarani; Josephine Lai; Victor J Hruby
Development of potent μ and δ opioid agonists with high lipophilicity.
Journal of medicinal chemistry 2011;54(1):382-6.
2011: Devki Sukhtankar; Todd W Vanderah; Anupama Chandramouli; Anne E Cress; Mark A Nelson; Alec Okun; Frank Porreca; Tamara King
Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.
Molecular pain 2011;7():81.
2011: Alec Okun; Milena DeFelice; Nathan Eyde; Jiyang Ren; Ramon Mercado; Tamara King; Frank Porreca
Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents.
Molecular pain 2011;7():4.
2011: Jin Yan; Rebecca M Edelmayer; Xiaomei Wei; Milena De Felice; Frank Porreca; G Dussor
Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache.
Pain 2011;152(1):106-13.
2010: T M Largent-Milnes; T Yamamoto; P Nair; J W Moulton; V J Hruby; Josephine Lai; Frank Porreca; T W Vanderah
Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.
British journal of pharmacology 2010;161(5):986-1001.
2010: Marina Vardanyan; Ohannes K Melemedjian; Theodore J Price; Michael H Ossipov; Josephine Lai; Ed Roberts; Terrence L Boos; Jeffrey R Deschamps; Arthur E Jacobson; Kenner C Rice; Frank Porreca
Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist.
Pain 2010;151(2):257-65.
2010: Qingmin Chen; Louis P Vera-Portocarrero; Michael H Ossipov; Marina Vardanyan; Josephine Lai; Frank Porreca
Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist.
Pancreas 2010;39(8):1220-5.
2010: Milena De Felice; Michael H Ossipov; Ruizhong Wang; G Dussor; Josephine Lai; Ian D Meng; Juliana Chichorro; John S Andrews; Suman Rakhit; Shawn Maddaford; David Dodick; Frank Porreca
Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers.
Brain : a journal of neurology 2010;133(Pt 8):2475-88.
2010: Yeon Sun Lee; Steve Fernandes; Vinod Kulkarani; Alexander V Mayorov; Peg Davis; Shou-wu Ma; Kathy Brown; Robert J Gillies; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.
Bioorganic & medicinal chemistry letters 2010;20(14):4080-4.
2010: Milena De Felice; Michael H Ossipov; Ruizhong Wang; Josephine Lai; Juliana Chichorro; Ian Meng; David W Dodick; Todd W Vanderah; G Dussor; Frank Porreca
Triptan-induced latent sensitization: a possible basis for medication overuse headache.
Annals of neurology 2010;67(3):325-37.
2009: Milena De Felice; Frank Porreca
Opiate-induced persistent pronociceptive trigeminal neural adaptations: potential relevance to opiate-induced medication overuse headache.
Cephalalgia : an international journal of headache 2009;29(12):1277-84.
2009: Tamara King; Louis Vera-Portocarrero; Tannia Gutierrez; Todd W Vanderah; G Dussor; Josephine Lai; Howard Fields; Frank Porreca
Unmasking the tonic-aversive state in neuropathic pain.
Nature neuroscience 2009;12(11):1364-6.
2009: Takashi Yamamoto; Padma Nair; Shou-wu Ma; Peg Davis; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Bioorganic & medicinal chemistry 2009;17(20):7337-43.
2009: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Josef Vagner; Vinod Kulkarni; Peg Davis; Shou-wu Ma; Edita Navratilova; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2009;52(16):5164-75.
2009: Ruben Vardanyan; Gokhale Vijay; Gary S Nichol; Lu Liu; Isuru Kumarasinghe; Peg Davis; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
Bioorganic & medicinal chemistry 2009;17(14):5044-53.
2009: Jill Roberts; Michael H Ossipov; Frank Porreca
Glial activation in the rostroventromedial medulla promotes descending facilitation to mediate inflammatory hypersensitivity.
The European journal of neuroscience 2009;30(2):229-41.
2009: Frank Porreca; Michael H Ossipov
Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options.
Pain medicine (Malden, Mass.) 2009;10(4):654-62.
2009: Frank Porreca; Todd W Vanderah
Spring pain research conference 2008.
Brain research reviews 2009;60(1):1.
2009: Wenjun Zhang; Shannon Gardell; Dongqin Zhang; Jennifer Y Xie; Richard S Agnes; Hamid Badghisi; Victor J Hruby; Naomi Rance; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors.
Brain : a journal of neurology 2009;132(Pt 3):778-87.
2009: Anna Vardanyan; Ruizhong Wang; Todd W Vanderah; Michael H Ossipov; Josephine Lai; Frank Porreca; Tamara King
TRPV1 receptor in expression of opioid-induced hyperalgesia.
The journal of pain : official journal of the American Pain Society 2009;10(3):243-52.
2009: Rebecca Edelmayer; Todd W Vanderah; Lisa Majuta; En-Tan Zhang; Beatriz Fioravanti; Milena De Felice; Juliana G Chichorro; Michael H Ossipov; Tamara King; Josephine Lai; Shashi H Kori; Andrew C Nelsen; Keri E Cannon; Mary M Heinricher; Frank Porreca
Medullary pain facilitating neurons mediate allodynia in headache-related pain.
Annals of neurology 2009;65(2):184-93.
2009: Cyril Rivat; Louis P Vera-Portocarrero; Mohab M Ibrahim; Heriberto P Mata; Nicola J Stagg; Milena De Felice; Frank Porreca; T Philip Malan
Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.
The European journal of neuroscience 2009;29(4):727-37.
2009: Padma Nair; Takashi Yamamoto; Vinod Kulkarni; Sharif Moye; Edita Navratilova; Peg Davis; Tally Largent; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Josephine Lai; Frank Porreca; Victor J Hruby
Novel bifunctional peptides as opioid agonists and NK-1 antagonists.
Advances in experimental medicine and biology 2009;611():537-8.
2009: YeonSun Lee; Ravil Petrov; Vinod Kulkarni; Byoung J Min; Shou-wu Ma; Peg Davis; Janice Oyarzo; Todd W Vanderah; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.
Advances in experimental medicine and biology 2009;611():517-8.
2009: Vinod V Kulkarni; Yeon Sun Lee; Christine Salibay; Peg Davis; Shou-wu Ma; Frank Porreca; Victor J Hruby
Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor.
Advances in experimental medicine and biology 2009;611():195-6.
2008: Miaw-Chyi Luo; Qingmin Chen; Michael H Ossipov; David R Rankin; Frank Porreca; Josephine Lai
Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia.
The journal of pain : official journal of the American Pain Society 2008;9(12):1096-105.
2008: Beatriz Fioravanti; Milena De Felice; Cheryl L Stucky; Karen A Medler; Miaw-Chyi Luo; Luis R Gardell; mukwaya Ibrahim; T Philip Malan; Henry I Yamamura; Michael H Ossipov; Tamara King; Josephine Lai; Frank Porreca; Todd W Vanderah
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(45):11593-602.
2008: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6334-47.
2008: Louis P Vera-Portocarrero; Michael H Ossipov; Tamara King; Frank Porreca
Reversal of inflammatory and noninflammatory visceral pain by central or peripheral actions of sumatriptan.
Gastroenterology 2008;135(4):1369-78.
2008: Richard S Agnes; Jinfa Ying; Katalin E Kövér; Yeon Sun Lee; Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J Hruby
Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Peptides 2008;29(8):1413-23.
2008: Josephine Lai; Miaw-chyi Luo; Qingmin Chen; Frank Porreca
Pronociceptive actions of dynorphin via bradykinin receptors.
Neuroscience letters 2008;437(3):175-9.
2008: Ruizhong Wang; Tamara King; Michael H Ossipov; Anthony J Rossomando; Todd W Vanderah; Pamela Harvey; Peter Cariani; Eric Frank; Dinah W Y Sah; Frank Porreca
Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury.
Nature neuroscience 2008;11(4):488-96.
2008: Todd W Vanderah; Tally Largent-Milnes; Josephine Lai; Frank Porreca; Richard A Houghten; Frédérique Menzaghi; Kazimierz Wisniewski; Jacek Stalewski; Javier Sueiras-Diaz; Robert Galyean; Claudio D Schteingart; Jean-Louis Junien; Jerzy Trojnar; PJ Rivière
Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors.
European journal of pharmacology 2008;583(1):62-72.
2008: Takashi Yamamoto; Padma Nair; Josef Vagner; Tally Largent-Milnes; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(5):1369-76.
2008: Tamara E King; Sangita C Pawar; Lisa Majuta; Isis C Sroka; Danyel Wynn; Manolis C Demetriou; Raymond B Nagle; Frank Porreca; Anne E Cress
The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model.
PloS one 2008;3(10):e3535.
2008: Yeon Sun Lee; Richard S Agnes; James P Cain; Vinod Kulkarni; Minying Cai; Christine Salibay; Kathy Ciano; Ravil R Petrov; Alexander V Mayorov; Josef Vagner; Dev Trivedi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Opioid and melanocortin receptors: do they have overlapping pharmacophores?
Biopolymers 2008;90(3):433-8.
2007: Yeon Sun Lee; Ravil R Petrov; chad park; Shou-wu Ma; Peg Davis; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
Journal of medicinal chemistry 2007;50(22):5528-32.
2007: Tamara King; Anna Vardanyan; Lisa Majuta; Ohannes Melemedjian; Raymond B Nagle; Anne E Cress; Todd W Vanderah; Josephine Lai; Frank Porreca
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer.
Pain 2007;132(1-2):154-68.
2007: Michael H Ossipov; Igor Bazov; Luis R Gardell; Justin Kowal; Tatiana Yakovleva; Ivan Usynin; Tomas J Ekström; Frank Porreca; Georgy Bakalkin
Control of chronic pain by the ubiquitin proteasome system in the spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(31):8226-37.
2007: Adriano Mollica; Giovanni Guardiani; Peg Davis; Shou-wu Ma; Frank Porreca; Josephine Lai; Luisa Mannina; Anatoli P Sobolev; Victor J Hruby
Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.
Journal of medicinal chemistry 2007;50(13):3138-42.
2007: Takashi Yamamoto; Padma Nair; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Todd W Vanderah; Henry I Yamamura; Frank Porreca; Victor J Hruby
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Journal of medicinal chemistry 2007;50(12):2779-86.
2007: En-Tan Zhang; Michael H Ossipov; Dong-Qin Zhang; Josephine Lai; Frank Porreca
Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons.
Pain 2007;129(1-2):143-54.
2007: Louis P Vera-Portocarrero; En-Tan Zhang; Tamara King; Michael H Ossipov; Todd W Vanderah; Josephine Lai; Frank Porreca
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.
Pain 2007;129(1-2):35-45.
2007: Yeon Sun Lee; Joel Nyberg; Sharif Moye; Richard S Agnes; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.
Bioorganic & medicinal chemistry letters 2007;17(8):2161-5.
2007: Ahmet Dogrul; S Ezgi Gülmez; Mustafa Deveci; Husamettin Gul; Michael H Ossipov; Frank Porreca; F Cankat Tulunay
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.
Anesthesia and analgesia 2007;104(4):927-35.
2007: Yeon Sun Lee; Richard S Agnes; Peg Davis; Shou-wu Ma; Hamid Badghisi; Josephine Lai; Frank Porreca; Victor J Hruby
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Journal of medicinal chemistry 2007;50(1):165-8.
2007: John J Lowery; Larisa Yeomans; Charles M Keyari; Peg Davis; Frank Porreca; Brian I Knapp; Jean M Bidlack; Edward J Bilsky; Robin Polt
Glycosylation improves the central effects of DAMGO.
Chemical biology & drug design 2007;69(1):41-7.
2006: Josephine Lai; Miaw-Chyi Luo; Qingmin Chen; Shouwu Ma; Luis R Gardell; Michael H Ossipov; Frank Porreca
Dynorphin A activates bradykinin receptors to maintain neuropathic pain.
Nature neuroscience 2006;9(12):1534-40.
2006: Ravil R Petrov; Ruben Vardanyan; Yeon S Lee; Shou-wu Ma; Peg Davis; Lucinda J Begay; Josephine Y Lai; Frank Porreca; Victor J Hruby
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.
Bioorganic & medicinal chemistry letters 2006;16(18):4946-50.
2006: Louis P Vera-Portocarrero; En-Tan Zhang; Michael H Ossipov; Jennifer Y Xie; Tamara King; Josephine Lai; Frank Porreca
Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization.
Neuroscience 2006;140(4):1311-20.
2006: Tamara King; Srinivas Rao; Todd W Vanderah; Qingmin Chen; Anna Vardanyan; Frank Porreca
Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran.
The journal of pain : official journal of the American Pain Society 2006;7(7):513-20.
2006: Frank Porreca; Todd W Vanderah; W Guo; M Barth; PR Dodey; V Peyrou; Jean-Michel Luccarini; Jean-Louis Junien; Didier Pruneau
Antinociceptive pharmacology of N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide, fumarate (LF22-0542), a novel nonpeptidic bradykinin B1 receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2006;318(1):195-205.
2006: Louis P Vera-Portocarrero; Jennifer Y Xie; Jennifer X Yie; Justin Kowal; Michael H Ossipov; Tamara King; Frank Porreca
Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis.
Gastroenterology 2006;130(7):2155-64.
2006: Richard S Agnes; Yeon Sun Lee; Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J Hruby
Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Journal of medicinal chemistry 2006;49(10):2868-75.
2006: Mohab M Ibrahim; Megan L Rude; Nicola J Stagg; Heriberto P Mata; Josephine Lai; Todd W Vanderah; Frank Porreca; Nancy E Buckley; Alexandros Makriyannis; T Philip Malan
CB2 cannabinoid receptor mediation of antinociception.
Pain 2006;122(1-2):36-42.
2006: Luis R Gardell; Tamara King; Michael H Ossipov; Kenner C Rice; Josephine Lai; Todd W Vanderah; Frank Porreca
Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery.
Neuroscience letters 2006;396(1):44-9.
2006: Yeon Sun Lee; Richard S Agnes; Hamid Badghisi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
Journal of medicinal chemistry 2006;49(5):1773-80.
2006: Adriano Mollica; Peg Davis; Shou-wu Ma; Frank Porreca; Josephine Lai; Victor J Hruby
Synthesis and biological activity of the first cyclic biphalin analogues.
Bioorganic & medicinal chemistry letters 2006;16(2):367-72.
2006: Victor J Hruby; Frank Porreca; Henry I Yamamura; Gordon Tollin; Richard S Agnes; Yeon Sun Lee; Minying Cai; Isabel D Alves; Scott M Cowell; Eva Varga; Peg Davis; Zdzislaw Salamon; William R Roeske; Todd W Vanderah; Josephine Lai
New paradigms and tools in drug design for pain and addiction.
The AAPS journal 2006;8(3):E450-60.
2005: Ahmet Dogrul; Edward J Bilsky; Michael H Ossipov; Josephine Lai; Frank Porreca
Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance.
Anesthesia and analgesia 2005;101(6):1730-5.
2005: Michael H Ossipov; Frank Porreca
Challenges in the development of novel treatment strategies for neuropathic pain.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(4):650-61.
2005: T Philip Malan; Frank Porreca
Lipid mediators regulating pain sensitivity.
Prostaglandins & other lipid mediators 2005;77(1-4):123-30.
2005: Tamara King; Luis R Gardell; Ruizhong Wang; Anna Vardanyan; Michael H Ossipov; T Philip Malan; Todd W Vanderah; Stephen P Hunt; Victor J Hruby; Josephine Lai; Frank Porreca
Role of NK-1 neurotransmission in opioid-induced hyperalgesia.
Pain 2005;116(3):276-88.
2005: Adriano Mollica; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.
Bioorganic & medicinal chemistry letters 2005;15(10):2471-5.
2005: Muthu Dhanasekaran; Michael M Palian; Isabel D Alves; Larisa Yeomans; Charles M Keyari; Peg Davis; Edward J Bilsky; Richard D Egleton; Henry I Yamamura; Neil E Jacobsen; Gordon Tollin; Victor J Hruby; Frank Porreca; Robin Polt
Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers.
Journal of the American Chemical Society 2005;127(15):5435-48.
2005: Mohab M Ibrahim; Frank Porreca; Josephine Lai; Phillip J Albrecht; Frank rice; Alla Khodorova; Gudarz Davar; Alexandros Makriyannis; Todd W Vanderah; Heriberto P Mata; T Philip Malan
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3093-8.
2005: Eva V Varga; Keiko Hosohata; Dariusz Borys; Edita Navratilova; Anders Nylen; Todd W Vanderah; Frank Porreca; William R Roeske; Henry I Yamamura
Antinociception depends on the presence of G protein gamma2-subunits in brain.
European journal of pharmacology 2005;508(1-3):93-8.
2005: Jennifer Y Xie; David Herman; Carl-Olav Stiller; Luis R Gardell; Michael H Ossipov; Josephine Lai; Frank Porreca; Todd W Vanderah
Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(2):409-16.
2005: Tamara King; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?
Neuro-Signals 2005;14(4):194-205.
2005: Miaw-Chyi Luo; Dong-Qin Zhang; Shou-wu Ma; Yuan-Yuan Huang; Sam J Shuster; Frank Porreca; Josephine Lai
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons.
Molecular pain 2005;1():29.
2005: Dinah W Y Sah; Michael H Ossipov; Anthony Rossomando; Laura Silvian; Frank Porreca
New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors.
Current topics in medicinal chemistry 2005;5(6):577-83.
2005: Michael H Ossipov; Josephine Lai; Tamara King; Todd W Vanderah; Frank Porreca
Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure.
Biopolymers 2005;80(2-3):319-24.
2005: Xuyuan Gu; Jinfa Ying; Byoung Min; James P Cain; Peg Davis; Patrick Willey; Edita Navratilova; Henry I Yamamura; Frank Porreca; Victor J Hruby
Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues.
Biopolymers 2005;80(2-3):151-63.
2004: Michael H Ossipov; Josephine Lai; Tamara King; Todd W Vanderah; T Philip Malan; Victor J Hruby; Frank Porreca
Antinociceptive and nociceptive actions of opioids.
Journal of neurobiology 2004;61(1):126-48.
2004: Nura O Elmagbari; Richard D Egleton; Michael M Palian; John J Lowery; Wendi R Schmid; Peg Davis; Edita Navratilova; Muthu Dhanasekaran; Charles M Keyari; Henry I Yamamura; Frank Porreca; Victor J Hruby; Robin Polt; Edward J Bilsky
Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides.
The Journal of pharmacology and experimental therapeutics 2004;311(1):290-7.
2004: Xuyuan Gu; Jinfa Ying; Richard S Agnes; Edita Navratilova; Peg Davis; Gannon Stahl; Frank Porreca; Henry I Yamamura; Victor J Hruby
Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues.
Organic letters 2004;6(19):3285-8.
2004: Qingmin Chen; Tamara King; Todd W Vanderah; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics.
The journal of pain : official journal of the American Pain Society 2004;5(5):281-9.
2004: Aline Quartilho; Heriberto P Mata; Mohab M Ibrahim; Todd W Vanderah; Michael H Ossipov; Josephine Lai; Frank Porreca; T Philip Malan
Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists.
Anesthesiology 2004;100(6):1538-44.
2004: Isabel D Alves; Scott M Cowell; Yeon Sun Lee; Xuejun Tang; Peg Davis; Frank Porreca; Victor J Hruby
A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands.
Biochemical and biophysical research communications 2004;318(2):335-40.
2004: Subramaniam Ananthan; Naveen K Khare; Surendra K Saini; Lainne E Seitz; Jeffrey L Bartlett; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman; Edward J Bilsky
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Journal of medicinal chemistry 2004;47(6):1400-12.
2004: Josephine Lai; Frank Porreca; John C Hunter; Michael S Gold
Voltage-gated sodium channels and hyperalgesia.
Annual review of pharmacology and toxicology 2004;44():371-97.
2004: Luis R Gardell; mukwaya Ibrahim; Ruizhong Wang; Zaijie Jim Wang; Michael H Ossipov; T Philip Malan; Frank Porreca; Josephine Lai
Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.
Neuroscience 2004;123(1):43-52.
2003: Luis R Gardell; Ruizhong Wang; Chris Ehrenfels; Michael H Ossipov; Anthony J Rossomando; Stephan Miller; Carolyn Buckley; Amber K Cai; Albert Tse; Susan F Foley; BangJian Gong; Lee Walus; Paul Carmillo; Dane Worley; Carol Huang; Thomas Engber; Blake Pepinsky; Richard L Cate; Todd W Vanderah; Josephine Lai; Dinah W Y Sah; Frank Porreca
Multiple actions of systemic artemin in experimental neuropathy.
Nature medicine 2003;9(11):1383-9.
2003: Aline Quartilho; Heriberto P Mata; Mohab M Ibrahim; Todd W Vanderah; Frank Porreca; Alexandros Makriyannis; T Philip Malan
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors.
Anesthesiology 2003;99(4):955-60.
2003: Luis R Gardell; Todd W Vanderah; S E Gardell; Ruizhong Wang; Michael H Ossipov; Josephine Lai; Frank Porreca
Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(23):8370-9.
2003: Mohab M Ibrahim; Hongfeng Deng; Alexander Zvonok; Debra A Cockayne; Joyce Kwan; Heriberto P Mata; Todd W Vanderah; Josephine Lai; Frank Porreca; Alexandros Makriyannis; T Philip Malan
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10529-33.
2003: Ahmet Dogrul; Luis R Gardell; Michael H Ossipov; F Cankat Tulunay; Josephine Lai; Frank Porreca
Reversal of experimental neuropathic pain by T-type calcium channel blockers.
Pain 2003;105(1-2):159-68.
2003: Subramaniam Ananthan; Naveen K Khare; Surendra K Saini; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman
Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.
Bioorganic & medicinal chemistry 2003;11(18):4143-54.
2003: Chiyi Xiong; Junyi Zhang; Peg Davis; Wei Wang; Jinfa Ying; Frank Porreca; Victor J Hruby
Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics.
Chemical communications (Cambridge, England) 2003;(13):1598-9.
2003: Michael H Ossipov; Josephine Lai; Todd W Vanderah; Frank Porreca
Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance.
Life sciences 2003;73(6):783-800.
2003: Victor J Hruby; Richard S Agnes; Peg Davis; Shou-wu Ma; Yeon Sun Lee; Todd W Vanderah; Josephine Lai; Frank Porreca
Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.
Life sciences 2003;73(6):699-704.
2003: Josephine Lai; John C Hunter; Frank Porreca
The role of voltage-gated sodium channels in neuropathic pain.
Current opinion in neurobiology 2003;13(3):291-7.
2003: Dinah W Y Sah; Michael H Ossipo; Frank Porreca
Neurotrophic factors as novel therapeutics for neuropathic pain.
Nature reviews. Drug discovery 2003;2(6):460-72.
2003: Subramaniam Ananthan; Hollis S Kezar; Surendra K Saini; Naveen K Khare; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.
Bioorganic & medicinal chemistry letters 2003;13(3):529-32.
2003: T Philip Malan; Mohab M Ibrahim; Josephine Lai; Todd W Vanderah; Alexandros Makriyannis; Frank Porreca
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?
Current opinion in pharmacology 2003;3(1):62-7.
2003: Keiko Hosohata; Eva V Varga; Josue Alfaro-Lopez; Xuejun Tang; Todd W Vanderah; Frank Porreca; Victor J Hruby; William R Roeske; Henry I Yamamura
(2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain.
The Journal of pharmacology and experimental therapeutics 2003;304(2):683-8.
2003: Ruizhong Wang; W Guo; Michael H Ossipov; Todd W Vanderah; Frank Porreca; Josephine Lai
Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain.
Neuroscience 2003;121(3):815-24.
2002: T Philip Malan; Mohab M Ibrahim; Todd W Vanderah; Alexandros Makriyannis; Frank Porreca
Inhibition of pain responses by activation of CB(2) cannabinoid receptors.
Chemistry and physics of lipids 2002;121(1-2):191-200.
2002: Luis R Gardell; Michael H Ossipov; Todd W Vanderah; Josephine Lai; Frank Porreca
Dynorphin-independent spinal cannabinoid antinociception.
Pain 2002;100(3):243-8.
2002: Michael H Ossipov; En-Tan Zhang; Cristina Carvajal; Luis R Gardell; Rémi Quirion; Yvan Dumont; Josephine Lai; Frank Porreca
Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(22):9858-67.
2002: Ahmet Dogrul; Luis R Gardell; Shouwu Ma; Michael H Ossipov; Frank Porreca; Josephine Lai
'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice.
Pain 2002;100(1-2):203-9.
2002: Luis R Gardell; Ruizhong Wang; Shannon E Burgess; Michael H Ossipov; Todd W Vanderah; T Philip Malan; Josephine Lai; Frank Porreca
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6747-55.
2002: Luis R Gardell; Shannon E Burgess; Ahmet Dogrul; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Pronociceptive effects of spinal dynorphin promote cannabinoid-induced pain and antinociceptive tolerance.
Pain 2002;98(1-2):79-88.
2002: Shannon E Burgess; Luis R Gardell; Michael H Ossipov; T Philip Malan; Todd W Vanderah; Josephine Lai; Frank Porreca
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(12):5129-36.
2002: Frank Porreca; Michael H Ossipov; G F Gebhart
Chronic pain and medullary descending facilitation.
Trends in neurosciences 2002;25(6):319-25.
2002: T Philip Malan; Heriberto P Mata; Frank Porreca
Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain.
Anesthesiology 2002;96(5):1161-7.
2002: Josephine Lai; Michael S Gold; Chang Sook Kim; Di Bian; Michael H Ossipov; John C Hunter; Frank Porreca
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.
Pain 2002;95(1-2):143-52.
2001: T Philip Malan; Mohab M Ibrahim; Hongfeng Deng; Q Liu; Heriberto P Mata; Todd W Vanderah; Frank Porreca; Alexandros Makriyannis
CB2 cannabinoid receptor-mediated peripheral antinociception.
Pain 2001;93(3):239-45.
2001: Josephine Lai; Michael H Ossipov; Todd W Vanderah; T Philip Malan; Frank Porreca
Neuropathic pain: the paradox of dynorphin.
Molecular interventions 2001;1(3):160-7.
2001: Mohab M Ibrahim; Heriberto P Mata; M Chawla; Josephine Lai; Frank Porreca; T Philip Malan
Allodynia and hyperalgesia produced by specific inhibition of spinal c-fos expression: lack of correlation with dynorphin content.
The journal of pain : official journal of the American Pain Society 2001;2(4):241-9.
2001: Frank Porreca; Shannon E Burgess; Luis R Gardell; Todd W Vanderah; T Philip Malan; Michael H Ossipov; D A Lappi; Josephine Lai
Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):5281-8.
2001: I I Simoneau; M S Hamza; Heriberto P Mata; Erin M Siegel; Todd W Vanderah; Frank Porreca; Alexandros Makriyannis; T Philip Malan
The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.
Anesthesiology 2001;94(5):882-7.
2001: Todd W Vanderah; Michael H Ossipov; Josephine Lai; T Philip Malan; Frank Porreca
Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin.
Pain 2001;92(1-2):5-9.
2001: S Liao; MD Shenderovich; Katalin E Kövér; Z Zhang; Keiko Hosohata; Peg Davis; Frank Porreca; Henry I Yamamura; V J Hurby
Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I.
The journal of peptide research : official journal of the American Peptide Society 2001;57(4):257-76.
2001: Zaijie Jim Wang; Luis R Gardell; Michael H Ossipov; Todd W Vanderah; Miles B Brennan; Ute Hochgeschwender; Victor J Hruby; T Philip Malan; Josephine Lai; Frank Porreca
Pronociceptive actions of dynorphin maintain chronic neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1779-86.
2001: H Sun; K Ren; C M Zhong; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections.
Pain 2001;90(1-2):105-11.
2001: Andrzej W Lipkowski; Aleksandra Misicka; Keiko Hosohata; Peg Davis; Henry I Yamamura; Frank Porreca; Victor J Hruby
Biological properties of Phe(o)-opioid peptide analogues.
Life sciences 2001;68(8):969-72.
2001: Todd W Vanderah; N M Suenaga; Michael H Ossipov; T Philip Malan; Josephine Lai; Frank Porreca
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(1):279-86.
2000: Ahmet Dogrul; Michael H Ossipov; J Lai; T Philip Malan; Frank Porreca
Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats.
Neuroscience letters 2000;292(2):115-8.
2000: Todd W Vanderah; Luis R Gardell; Shannon E Burgess; mukwaya Ibrahim; Ahmet Dogrul; C M Zhong; En-Tan Zhang; T Philip Malan; Michael H Ossipov; Josephine Lai; Frank Porreca
Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):7074-9.
2000: CJ Kovelowski; Michael H Ossipov; H Sun; Josephine Lai; T Philip Malan; Frank Porreca
Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat.
Pain 2000;87(3):265-73.
2000: Michael H Ossipov; T Hong Sun; P Malan; Josephine Lai; Frank Porreca
Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats.
Neuroscience letters 2000;290(2):129-32.
2000: Michael H Ossipov; T P Jerussi; K Ren; H Sun; Frank Porreca
Differential effects of spinal (R)-ketoprofen and (S)-ketoprofen against signs of neuropathic pain and tonic nociception: evidence for a novel mechanism of action of (R)-ketoprofen against tactile allodynia.
Pain 2000;87(2):193-9.
2000: SK Joshi; X Su; Frank Porreca; Gerald F Gebhart
kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(15):5874-9.
2000: Edward J Bilsky; Richard D Egleton; SA Mitchell; Michael M Palian; Peg Davis; Jason D Huber; H Jones; Henry I Yamamura; J Janders; Thomas P Davis; Frank Porreca; Victor J Hruby; Robin Polt
Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.
Journal of medicinal chemistry 2000;43(13):2586-90.
2000: Q Tang; Ronald M Lynch; Frank Porreca; Josephine Lai
Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism.
Journal of neurophysiology 2000;83(5):2610-5.
2000: T Philip Malan; Michael H Ossipov; Luis R Gardell; mukwaya Ibrahim; Di Bian; Josephine Lai; Frank Porreca
Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats.
Pain 2000;86(1-2):185-94.
2000: Edward J Bilsky; X Qian; Victor J Hruby; Frank Porreca
Antinociceptive activity of [beta-methyl-2', 6'-dimethyltyrosine(1)]-substituted cyclic [D-Pen(2), D-Pen(5)]Enkephalin and [D-Ala(2),Asp(4)]Deltorphin analogs.
The Journal of pharmacology and experimental therapeutics 2000;293(1):151-8.
2000: Keiko Hosohata; J K Logan; Eva Varga; TH Burkey; Todd W Vanderah; Frank Porreca; Victor J Hruby; William R Roeske; Henry I Yamamura
The role of the G protein gamma(2) subunit in opioid antinociception in mice.
European journal of pharmacology 2000;392(3):R9-R11.
2000: Gregg Bonner; Peg Davis; Dagmar Stropova; S Edsall; Henry I Yamamura; Frank Porreca; Victor J Hruby
Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays.
Journal of medicinal chemistry 2000;43(4):569-80.
2000: Yoshiaki Hosohata; Todd W Vanderah; TH Burkey; Michael H Ossipov; CJ Kovelowski; I Sora; George R. Uhl; X Zhang; Kenner C Rice; William R Roeske; Victor J Hruby; Henry I Yamamura; Josephine Lai; Frank Porreca
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
European journal of pharmacology 2000;388(3):241-8.
2000: Michael H Ossipov; Josephine Lai; T Philip Malan; Frank Porreca
Spinal and supraspinal mechanisms of neuropathic pain.
Annals of the New York Academy of Sciences 2000;909():12-24.
2000: Josephine Lai; John C Hunter; Michael H Ossipov; Frank Porreca
Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons.
Methods in enzymology 2000;314():201-13.
1999: Josue Alfaro-Lopez; Toru Okayama; Keiko Hosohata; Peg Davis; Frank Porreca; Henry I Yamamura; Victor J Hruby
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.
Journal of medicinal chemistry 1999;42(26):5359-68.
1999: CJ Kovelowski; Michael H Ossipov; Victor J Hruby; Frank Porreca
Lesions of the dorsolateral funiculus block supraspinal opioid delta receptor mediated antinociception in the rat.
Pain 1999;83(2):115-22.
1999: Q Tang; R Gandhoke; A Burritt; Victor J Hruby; Frank Porreca; Josephine Lai
High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors.
The Journal of pharmacology and experimental therapeutics 1999;291(2):760-5.
1999: CJ Kovelowski; Di Bian; Victor J Hruby; Josephine Lai; Michael H Ossipov; Frank Porreca
Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat.
Brain research 1999;843(1-2):12-7.
1999: Andrzej W Lipkowski; Aleksandra Misicka; Peg Davis; Dagmar Stropova; J Janders; M Lachwa; Frank Porreca; Henry I Yamamura; Victor J Hruby
Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin.
Bioorganic & medicinal chemistry letters 1999;9(18):2763-6.
1999: Subramaniam Ananthan; Hollis S Kezar; R L Carter; Surendra K Saini; Kenner C Rice; J L Wells; Peg Davis; Heng Xu; Christina M Dersch; Edward J Bilsky; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Journal of medicinal chemistry 1999;42(18):3527-38.
1999: Frank Porreca; Josephine Lai; Di Bian; S Wegert; Michael H Ossipov; R M Eglen; LC Kassotakis; SD Novakovic; Douglas Rabert; L Sangameswaran; John C Hunter
A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7640-4.
1999: JM Lashbrook; Michael H Ossipov; John C Hunter; Robert Raffa; Ronald J Tallarida; Frank Porreca
Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats.
Pain 1999;82(1):65-72.
1999: Di Bian; Michael H Ossipov; mukwaya Ibrahim; Robert Raffa; Ronald J Tallarida; T Philip Malan; Josephine Lai; Frank Porreca
Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: restoration by MK-801 or dynorphin antiserum.
Brain research 1999;831(1-2):55-63.
1999: J B Owolabi; G Rizkalla; Ashok Tehim; Gregory M Ross; Richard J Riopelle; Rajender K Kamboj; Michael H Ossipov; Di Bian; S Wegert; Frank Porreca; DK Lee
Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat.
The Journal of pharmacology and experimental therapeutics 1999;289(3):1271-6.
1999: Z Wang; Edward J Bilsky; Danxin Wang; Frank Porreca; Wolfgang Sadée
3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice.
European journal of pharmacology 1999;371(1):1-9.
1999: H Bartosz-Bechowski; Peg Davis; J Slaninova; Ewa Malatynska; Dagmar Stropova; Frank Porreca; Henry I Yamamura; Victor J Hruby
Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.
The journal of peptide research : official journal of the American Peptide Society 1999;53(3):329-36.
1999: Michael H Ossipov; Di Bian; T Philip Malan; Josephine Lai; Frank Porreca
Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats.
Pain 1999;79(2-3):127-33.
1998: S Liao; Josue Alfaro-Lopez; MD Shenderovich; Keiko Hosohata; J Lin; X Li; Dagmar Stropova; Peg Davis; K A Jernigan; Frank Porreca; Henry I Yamamura; Victor J Hruby
De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.
Journal of medicinal chemistry 1998;41(24):4767-76.
1998: Subramaniam Ananthan; Cheryl A Johnson; R L Carter; S D Clayton; Kenner C Rice; Heng Xu; Peg Davis; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Journal of medicinal chemistry 1998;41(15):2872-81.
1998: Frank Porreca; Q B Tang; Di Bian; Maureen S Riedl; Robert Elde; Josephine Lai
Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury.
Brain research 1998;795(1-2):197-203.
1998: G Li; W Haq; L Xiang; B S Lou; R Hughes; I A De Leon; Peg Davis; TJ Gillespie; Marek Romanowski; Xiaoyun Zhu; Aleksandra Misicka; Andrzej W Lipkowski; Frank Porreca; Thomas P Davis; Henry I Yamamura; David F O'Brien; Victor J Hruby
Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.
Bioorganic & medicinal chemistry letters 1998;8(5):555-60.
1998: Yi-Feng Lu; Heng Xu; L Y Liu-Chen; C Chen; John S Partilla; G A Brine; Frank carroll; Kenner C Rice; J Lai; Frank Porreca; W Sadee; Richard B Rothman
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Synapse (New York, N.Y.) 1998;28(2):117-24.
1998: Di Bian; Michael H Ossipov; C Zhong; T Philip Malan; Frank Porreca
Tactile allodynia, but not thermal hyperalgesia, of the hindlimbs is blocked by spinal transection in rats with nerve injury.
Neuroscience letters 1998;241(2-3):79-82.
1998: Todd W Vanderah; Robert Raffa; JM Lashbrook; A Burritt; Victor J Hruby; Frank Porreca
Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats.
European journal of pain (London, England) 1998;2(3):267-78.
1998: CJ Kovelowski; Robert Raffa; Frank Porreca
Tramadol and its enantiomers differentially suppress c-fos-like immunoreactivity in rat brain and spinal cord following acute noxious stimulus.
European journal of pain (London, England) 1998;2(3):211-9.
1998: Q Ni; Heng Xu; John S Partilla; Kenner C Rice; Dorota Matecka; S N Calderon; Frank Porreca; J Lai; Helmut Schmidhammer; Roland Krassnig; Richard B Rothman
Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain.
Peptides 1998;19(6):1079-90.
1998: TH Burkey; Frederick J Ehlert; Yoshiaki Hosohata; Raymond M Quock; Scott M Cowell; Keiko Hosohata; Eva Varga; Dagmar Stropova; X Li; CA Slate; Hiroshi Nagase; Frank Porreca; Victor J Hruby; William R Roeske; Henry I Yamamura
The efficacy of delta-opioid receptor-selective drugs.
Life sciences 1998;62(17-18):1531-6.
1998: Heng Xu; Yi-Feng Lu; John S Partilla; J Pinto; S N Calderon; Dorota Matecka; Kenner C Rice; J Lai; Frank Porreca; Subramaniam Ananthan; Richard B Rothman
Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors.
Peptides 1998;19(2):343-50.
1997: Victor J Hruby; H Bartosz-Bechowski; Peg Davis; J Slaninova; Teresa Zalewska; Dagmar Stropova; Frank Porreca; Henry I Yamamura
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.
Journal of medicinal chemistry 1997;40(24):3957-62.
1997: R C Haaseth; Teresa Zalewska; Peg Davis; Henry I Yamamura; Frank Porreca; Victor J Hruby
Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands.
The journal of peptide research : official journal of the American Peptide Society 1997;50(3):171-7.
1997: Tinna M Laughlin; Todd W Vanderah; JM Lashbrook; ML Nichols; Michael H Ossipov; Frank Porreca; George L Wilcox
Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors.
Pain 1997;72(1-2):253-60.
1997: Aleksandra Misicka; S Cavagnero; R Horvath; Peg Davis; Frank Porreca; Henry I Yamamura; Victor J Hruby
Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors.
The journal of peptide research : official journal of the American Peptide Society 1997;50(1):48-54.
1997: Raymond M Quock; Yoshiaki Hosohata; Richard J Knapp; TH Burkey; Keiko Hosohata; X Zhang; Kenner C Rice; Hiroshi Nagase; Victor J Hruby; Frank Porreca; William R Roeske; Henry I Yamamura
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.
European journal of pharmacology 1997;326(1):101-4.
1997: S Wegert; Michael H Ossipov; ML Nichols; Di Bian; Todd W Vanderah; T Philip Malan; Frank Porreca
Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats.
Pain 1997;71(1):57-64.
1997: Josephine Lai; T J Crook; A Payne; Ronald M Lynch; Frank Porreca
Antisense targeting of delta opioid receptors in NG 108-15 cells: direct correlation between oligodeoxynucleotide uptake and receptor density.
The Journal of pharmacology and experimental therapeutics 1997;281(1):589-96.
1997: ML Nichols; Y Lopez; Michael H Ossipov; Di Bian; Frank Porreca
Enhancement of the antiallodynic and antinociceptive efficacy of spinal morphine by antisera to dynorphin A (1-13) or MK-801 in a nerve-ligation model of peripheral neuropathy.
Pain 1997;69(3):317-22.
1997: Gregg Bonner; Peg Davis; Dagmar Stropova; R Ferguson; Henry I Yamamura; Frank Porreca; Victor J Hruby
Opioid peptides: simultaneous delta agonism and mu antagonism in somatostatin analogues.
Peptides 1997;18(1):93-100.
1997: Aleksandra Misicka; Andrzej W Lipkowski; R Horvath; Peg Davis; Frank Porreca; Henry I Yamamura; Victor J Hruby
Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.
Life sciences 1997;60(15):1263-9.
1997: Michael H Ossipov; Y Lopez; Di Bian; ML Nichols; Frank Porreca
Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury.
Anesthesiology 1997;86(1):196-204.