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Jeffrey Conn

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Karen J Gregory; Craig W Lindsley; Jens Meiler; Elizabeth D Nguyen; Sean D Reiff; Emma F Squire; Shaun R Stauffer; P Jeffrey Conn
Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a "Molecular Switch" in PAM Pharmacology.
M J Noetzel; S R Stauffer; P N Vinson; Zixiu Xiang; K J Gregory; Craig W Lindsley; J T Manka; Colleen M Niswender; P Jeffrey Conn
A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.
Michael S Poslusney; Douglas J Sheffler; Thomas J Utley; Thomas M Bridges; P Jeffrey Conn; J Scott Daniels; Patrick R Gentry; Craig W Lindsley; Bruce J Melancon; Colleen M Niswender; Michael R Wood
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.

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All Publications

2013: Karen J Gregory; Craig W Lindsley; Jens Meiler; Elizabeth D Nguyen; Sean D Reiff; Emma F Squire; Shaun R Stauffer; P Jeffrey Conn
Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a "Molecular Switch" in PAM Pharmacology.
Molecular pharmacology 2013;83(5):991-1006.
2013: M J Noetzel; S R Stauffer; P N Vinson; Zixiu Xiang; K J Gregory; Craig W Lindsley; J T Manka; Colleen M Niswender; P Jeffrey Conn
A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.
Molecular pharmacology 2013;83(4):835-47.
2013: Michael S Poslusney; Douglas J Sheffler; Thomas J Utley; Thomas M Bridges; P Jeffrey Conn; J Scott Daniels; Patrick R Gentry; Craig W Lindsley; Bruce J Melancon; Colleen M Niswender; Michael R Wood
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.
Bioorganic & medicinal chemistry letters 2013;23(6):1860-4.
2013: Jerri M Rook; Shaun R Stauffer; Paige N Vinson; Zixiu Xiang; Ya Zhou; Thomas M Bridges; Hyekyung P Cho; J Scott Daniels; F Edward Dudek; Rocco D Gogliotti; Karen J Gregory; Carrie K Jones; Craig W Lindsley; Jason T Manka; Colleen M Niswender; Meredith J Noetzel; Wendy A Pouliot; P Jeffrey Conn
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.
Biological psychiatry 2013;73(6):501-9.
2013: Kari A Johnson; Carrie K Jones; Marketa Marvanova; M Sib Ansari; Ronald M Baldwin; Michael Bubser; P Jeffrey Conn; Mohammed N Tantawy; Colleen M Niswender
The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.
Neuropharmacology 2013;66():187-95.
2013: Takaki Kiritoshi; Craig W Lindsley; Wenjie Ren; Shaun R Stauffer; Hao Sun; P Jeffrey Conn; Volker Neugebauer
Modulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1.
Neuropharmacology 2013;66():170-8.
2013: Shen Yin; Rocio Zamorano; P Jeffrey Conn; Colleen M Niswender
Functional selectivity induced by mGlu₄ receptor positive allosteric modulation and concomitant activation of Gq coupled receptors.
Neuropharmacology 2013;66():122-32.
2013: Bruce J Melancon; Colleen M Niswender; Michael S Poslusney; Douglas J Sheffler; James C Tarr; Thomas J Utley; Thomas M Bridges; P Jeffrey Conn; J Scott Daniels; Patrick R Gentry; Craig W Lindsley; Margrith E Mattmann; Michael R Wood
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.
Bioorganic & medicinal chemistry letters 2013;23(2):412-6.
2013: Frank S Menniti; Jayvardhan Pandit; P Jeffrey Conn; Craig W Lindsley; Panayiotis Zagouras; Robert A Volkmann
Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks.
Current topics in medicinal chemistry 2013;13(1):26-54.
2013: Douglas J Sheffler; James C Tarr; Michael R Wood; Kimberly M Lovell; Colleen M Niswender; Christian Sevel; Sheridan J S Carrington; Hyekyung P Cho; P Jeffrey Conn; Gregory J Digby; Corey R Hopkins; Uyen M Le; Craig W Lindsley
Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.
Bioorganic & medicinal chemistry letters 2013;23(1):223-7.
2013: Uyen M Le; Craig W Lindsley; Bruce J Melancon; Colleen M Niswender; Alice L Rodriguez; Douglas J Sheffler; Thomas J Utley; Daryl Venable; Paige N Vinson; Michael R Wood; Anna L Blobaum; Thomas M Bridges; P Jeffrey Conn; J Scott Daniels; Carrie K Jones; Atin Lamsal; Corey R Hopkins
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Bioorganic & medicinal chemistry letters 2013;23(1):346-50.
2012: Gregory J Digby; Atin Lamsal; Evan P Lebois; Craig W Lindsley; Colleen M Niswender; Christian Sevel; Douglas J Sheffler; Thomas J Utley; Michael R Wood; Thomas M Bridges; P Jeffrey Conn
Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.
ACS chemical neuroscience 2012;3(12):1025-36.
2012: Daniel J Foster; Carrie K Jones; P Jeffrey Conn
Emerging approaches for treatment of schizophrenia: modulation of cholinergic signaling.
Discovery medicine 2012;14(79):413-20.
2012: Shyama Sidique; Layton H Smith; Li Yang; P Jeffrey Conn; Russell Dahl; Raveendra-Panickar Dhanya; Manoranjan S D'Souza; Arianna Mangravita-Novo; Athina Markou; Hilary Highfield Nickols; Svetlana Semenova; Douglas J Sheffler; Nicholas D P Cosford
Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.
Journal of medicinal chemistry 2012;55(22):9434-45.
2012: James C Tarr; Mark L Turlington; Thomas J Utley; Michael R Wood; Zixui Xiang; Ryan D Morrison; Colleen M Niswender; Tristano Pancani; Paul R Reid; Douglas J Sheffler; Anna L Blobaum; Thomas M Bridges; Hyekyung P Cho; P Jeffrey Conn; J Scott Daniels; Rebecca Klar; Michael T Klein; Craig W Lindsley
Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.
ACS chemical neuroscience 2012;3(11):884-95.
2012: Michael S Poslusney; Christian Sevel; Douglas J Sheffler; Thomas J Utley; Thomas M Bridges; P Jeffrey Conn; J S Daniels; Nathan R Kett; Craig W Lindsley; Ryan D Morrison; Colleen M Niswender; Michael R Wood
Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists.
Bioorganic & medicinal chemistry letters 2012;22(22):6923-8.
2012: Meredith J Noetzel; Carrie K Jones; P Jeffrey Conn
Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signaling.
Discovery medicine 2012;14(78):335-43.
2012: Karen J Gregory; Craig W Lindsley; Colleen M Niswender; Meredith J Noetzel; Alice L Rodriguez; Jerri M Rook; Shaun R Stauffer; Paige N Vinson; Ya Zhou; Brian A Chauder; Aspen C Chun; Kyle A Emmitte; Andrew S Felts; P Jeffrey Conn
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.
Molecular pharmacology 2012;82(5):860-75.
2012: Jason T Manka; Colleen M Niswender; Thomas Steckler; Paige N Vinson; C David Weaver; Richard Williams; Ya Zhou; José M Bartolomé; P Jeffrey Conn; J Scott Daniels; Emily Days; Kiran Gogi; Karen J Gregory; Elizabeth J Herman; Satya Jadhav; Carrie K Jones; Hilde Lavreysen; Craig W Lindsley; Gregor J Macdonald; Claire Mackie; Shaun R Stauffer
Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.
Bioorganic & medicinal chemistry letters 2012;22(20):6481-5.
2012: Ryan D Morrison; Colleen M Niswender; Alice L Rodriguez; Roger Rush; Raymundo Sanchez-Ponce; Tammy S Santomango; Donald Stec; Daryl F Venable; Brittney S Bates; Anna L Blobaum; Katrina A Brewer; Thomas M Bridges; Frank W Byers; P Jeffrey Conn; Melany M Corlew; Kyle A Emmitte; Andrew S Felts; Carrie K Jones; Craig W Lindsley; Jason Manka; J Scott Daniels
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(9):1834-45.
2012: Ralf Mueller; Colleen M Niswender; C David Weaver; Mariusz Butkiewicz; P Jeffrey Conn; Eric S Dawson; Corey R Hopkins; Craig W Lindsley; Jens Meiler
Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators.
Journal of molecular modeling 2012;18(9):4437-46.
2012: Gregory J Digby; Kimberly Italiano; Carrie K Jones; Evan P Lebois; Craig W Lindsley; Sarah E Mennenga; Ryan Morrison; Natali E Nemirovsky; Colleen M Niswender; Meredith J Noetzel; M Foster Olive; Douglas J Sheffler; Thomas J Utley; Adam G Walker; Zixiu Xiang; Heather A Bimonte-Nelson; Jacob Bode; Michael Bubser; Nellie E Byun; Bryan W Camp; Hyekyung P Cho; J Scott Daniels; Albert A Davis; P Jeffrey Conn
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(25):8532-44.
2012: Bruce J Melancon; Ryan D Morrison; Colleen M Niswender; Sam A Saleh; Douglas J Sheffler; James C Tarr; Thomas J Utley; Thomas M Bridges; Brian A Chauder; Hyekyung P Cho; P Jeffrey Conn; J Scott Daniels; Rocco D Gogliotti; Evan P Lebois; Craig W Lindsley; Michael R Wood
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.
Bioorganic & medicinal chemistry letters 2012;22(10):3467-72.
2012: Morgane Thomsen; Jürgen Wess; Jeffrey E Wessell; P Jeffrey Conn; Brian S Fulton; Craig W Lindsley; S Barak Caine
Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice.
Psychopharmacology 2012;220(4):673-85.
2012: Ralf Mueller; Colleen M Niswender; Christopher M Olsen; Alice L Rodriguez; Danny G Winder; Jens Meiler; Usha N Menon; Brittney S Bates; Brian A Chauder; P Jeffrey Conn; Eric S Dawson; Kyle A Emmitte; Andrew S Felts; Karen J Gregory; Sataywan B Jadhav; Carrie K Jones; Alexander S Kane; Jeffrey P Lamb; Craig W Lindsley
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound.
ChemMedChem 2012;7(3):406-14.
2012: P Jeffrey Conn
An interview with P. Jeffrey Conn.
Trends in pharmacological sciences 2012;33(3):119-21.
2012: Zixiu Xiang; Carrie K Jones; Craig W Lindsley; Analisa D Thompson; P Jeffrey Conn
Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics 2012;340(3):595-603.
2012: Paige N Vinson; P Jeffrey Conn
Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
Neuropharmacology 2012;62(3):1461-72.
2012: Bruce J Melancon; Colleen M Niswender; Michael R Wood; Arthur Christopoulos; P Jeffrey Conn; Kyle A Emmitte; Corey R Hopkins; Craig W Lindsley
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.
Journal of medicinal chemistry 2012;55(4):1445-64.
2012: Carrie K Jones; Craig W Lindsley; Ryan D Morrison; Analisa D Thompson; Nathalie Turle-Lorenzo; Marianne Amalric; Anna L Blobaum; Jacob Bode; Thomas M Bridges; Michael Bubser; P Jeffrey Conn; J Scott Daniels; Jonathan W Dickerson; Darren W Engers; Corey R Hopkins; Kimberly Italiano; Satyawan Jadhav; Colleen M Niswender
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics 2012;340(2):404-21.
2012: Meredith J Noetzel; Alice L Rodriguez; Jerri M Rook; Shaun R Stauffer; Paige N Vinson; C David Weaver; Zixiu Xiang; Y Zhou; J Scott Daniels; Emily Days; Carrie K Jones; Hilde Lavreysen; Craig W Lindsley; Colleen M Niswender; Hyekyung P Cho; P Jeffrey Conn
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.
Molecular pharmacology 2012;81(2):120-33.
2011: Julie R Field; Adam G Walker; P Jeffrey Conn
Targeting glutamate synapses in schizophrenia.
Trends in molecular medicine 2011;17(12):689-98.
2011: Carrie K Jones; Craig W Lindsley; Stacey R Lindsley; Ryan Morrison; Colleen M Niswender; Yoland Smith; Analisa D Thompson; C David Weaver; Rocio Zamorano; Ya Zhou; Anna L Blobaum; Jim Bogenpohl; P Jeffrey Conn; J Scott Daniels; Darren W Engers; Julie R Field; Rocco D Gogliotti; Satyawan Jadhav; Corey R Hopkins
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model.
Journal of medicinal chemistry 2011;54(21):7639-47.
2011: Mohammed N Tantawy; Todd E Peterson; Jerri M Rook; M Sib Ansari; Ronald M Baldwin; P Jeffrey Conn; Kari Johnson; Carrie K Jones; Robert M Kessler
Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot.
Synapse (New York, N.Y.) 2011;65(11):1173-80.
2011: Kari A Johnson; Colleen M Niswender; P Jeffrey Conn; Zixiu Xiang
Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
Neuroscience letters 2011;504(2):102-6.
2011: Stephen R Marder; Bita Moghaddam; Eric J Nestler; Bryan Roth; Akira Saw; Edward M Scolnick; Patrick F Sullivan; Daniel R Welnberger; Akira Sawa; Schahram Akbarian; John A Allen; Robert W Buchanan; Brian Campbell; Marc G Caron; P Jeffrey Conn; Susan R George; Mark A Geyer; Jay A Gingrich; Alessandro Guidotti; Stephen J Haggarty; Maria Karayiorgou; John H Krystal; Amanda J Law; Jeffrey A Lieberman; Michelle Solis
Advancing drug discovery for schizophrenia.
Annals of the New York Academy of Sciences 2011;1236():30-43.
2011: Paul R Reid; Thomas M Bridges; Douglas J Sheffler; Hyekyung P Cho; L Michelle Lewis; Emily Days; J Scott Daniels; Carrie K Jones; Colleen M Niswender; C David Weaver; P Jeffrey Conn; Craig W Lindsley; Michael R Wood
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.
Bioorganic & medicinal chemistry letters 2011;21(9):2697-701.
2011: Michael R Wood; Corey R Hopkins; John T Brogan; P Jeffrey Conn; Craig W Lindsley
"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.
Biochemistry 2011;50(13):2403-10.
2011: Yiu-Yin Cheung; Rocio Zamorano; Anna L Blobaum; C David Weaver; P Jeffrey Conn; Craig W Lindsley; Colleen M Niswender; Corey R Hopkins
Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄.
ACS combinatorial science 2011;13(2):159-65.
2011: Richard Williams; Jason T Manka; Alice L Rodriguez; Paige N Vinson; Colleen M Niswender; C David Weaver; Carrie K Jones; P Jeffrey Conn; Craig W Lindsley; Shaun R Stauffer
Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.
Bioorganic & medicinal chemistry letters 2011;21(5):1350-3.
2011: Darren W Engers; Julie R Field; Uyen Le; Ya Zhou; Julie D Bolinger; Rocio Zamorano; Anna L Blobaum; Carrie K Jones; Satyawan Jadhav; C David Weaver; P Jeffrey Conn; Craig W Lindsley; Colleen M Niswender; Corey R Hopkins
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.
Journal of medicinal chemistry 2011;54(4):1106-10.
2011: Raveendra-Panickar Dhanya; Ananda Herath; Athina Markou; Hilary Highfield Nickols; Svetlana Semenova; Douglas J Sheffler; Shyama Sidique; Li Yang; Robert Ardecky; P Jeffrey Conn; Russell Dahl; Nicholas D P Cosford
Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats.
Journal of medicinal chemistry 2011;54(1):342-53.
2011: Douglas J Sheffler; Karen J Gregory; Jerri M Rook; P Jeffrey Conn
Allosteric modulation of metabotropic glutamate receptors.
Advances in pharmacology (San Diego, Calif.) 2011;62():37-77.
2011: Karen J Gregory; Elizabeth N Dong; Jens Meiler; P Jeffrey Conn
Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.
Neuropharmacology 2011;60(1):66-81.
2010: Alice L Rodriguez; Mark D Grier; Carrie K Jones; Elizabeth J Herman; Alexander S Kane; Randy L Smith; Richard Williams; Ya Zhou; Joy E Marlo; Emily L Days; Tasha N Blatt; Satyawan Jadhav; Usha N Menon; Paige N Vinson; Jerri M Rook; Shaun R Stauffer; Colleen M Niswender; Craig W Lindsley; C David Weaver; P Jeffrey Conn
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
Molecular pharmacology 2010;78(6):1105-23.
2010: Thomas M Bridges; J Phillip Kennedy; Corey R Hopkins; P Jeffrey Conn; Craig W Lindsley
Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.
Bioorganic & medicinal chemistry letters 2010;20(19):5617-22.
2010: Edward W Lowe; Alysia Ferrebee; Alice L Rodriguez; P Jeffrey Conn; Jens Meiler
3D-QSAR CoMFA study of benzoxazepine derivatives as mGluR5 positive allosteric modulators.
Bioorganic & medicinal chemistry letters 2010;20(19):5922-4.
2010: Darren W Engers; Patrick R Gentry; Richard Williams; Julie D Bolinger; C David Weaver; Usha N Menon; P Jeffrey Conn; Craig W Lindsley; Colleen M Niswender; Corey R Hopkins
Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).
Bioorganic & medicinal chemistry letters 2010;20(17):5175-8.
2010: Xinchun Jin; Svetlana Semenova; Li Yang; Robert Ardecky; Douglas J Sheffler; Russell Dahl; P Jeffrey Conn; Nicholas D P Cosford; Athina Markou
The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(10):2021-36.
2010: Andrew S Felts; Stacey R Lindsley; Jeffrey P Lamb; Alice L Rodriguez; Usha N Menon; Satyawan Jadhav; Carrie K Jones; P Jeffrey Conn; Craig W Lindsley; Kyle A Emmitte
3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.
Bioorganic & medicinal chemistry letters 2010;20(15):4390-4.
2010: Gregory J Digby; Jana K Shirey; P Jeffrey Conn
Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.
Molecular bioSystems 2010;6(8):1345-54.
2010: Elizabeth A Hackler; N E Byun; C K Jones; Jason Williams; R Baheza; S Sengupta; M D Grier; Malcolm J Avison; P Jeffrey Conn; John C Gore
Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation.
Neuroscience 2010;168(1):209-18.
2010: Thomas M Bridges; Evan P LeBois; Corey R Hopkins; Michael R Wood; Carrie K Jones; P Jeffrey Conn; Craig W Lindsley
The antipsychotic potential of muscarinic allosteric modulation.
Drug news & perspectives 2010;23(4):229-40.
2010: Peng Zhang; Mu-Fa Zou; Alice L Rodriguez; P Jeffrey Conn; Amy Hauck Newman
Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.
Bioorganic & medicinal chemistry 2010;18(9):3026-35.
2010: Nicole R Miller; R Nathan Daniels; David Lee; P Jeffrey Conn; Craig W Lindsley
Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists.
Bioorganic & medicinal chemistry letters 2010;20(7):2174-7.
2010: Colleen M Niswender; Kari A Johnson; Nicole R Miller; Jennifer E Ayala; Qingwei Luo; Richard Williams; Samir Saleh; Darren Orton; C David Weaver; P Jeffrey Conn
Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.
Molecular pharmacology 2010;77(3):459-68.
2010: Morgane Thomsen; P Jeffrey Conn; Craig Lindsley; Jürgen Wess; Joon Y Boon; Brian S Fulton; Anders Fink-Jensen; S Barak Caine
Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation.
The Journal of pharmacology and experimental therapeutics 2010;332(3):959-69.
2010: Thomas M Bridges; J Phillip Kennedy; Hyekyung P Cho; Micah L Breininger; Patrick R Gentry; Corey R Hopkins; P Jeffrey Conn; Craig W Lindsley
Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.
Bioorganic & medicinal chemistry letters 2010;20(2):558-62.
2010: Colleen M Niswender; P Jeffrey Conn
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Annual review of pharmacology and toxicology 2010;50():295-322.
2009: Ya Zhou; Alice L Rodriguez; Richard Williams; C David Weaver; P Jeffrey Conn; Craig W Lindsley
Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS.
Bioorganic & medicinal chemistry letters 2009;19(23):6502-6.
2009: Andrew S Felts; Sam A Saleh; Uyen Le; Alice L Rodriguez; C David Weaver; P Jeffrey Conn; Craig W Lindsley; Kyle A Emmitte
Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
Bioorganic & medicinal chemistry letters 2009;19(23):6623-6.
2009: Kari A Johnson; P Jeffrey Conn; Colleen M Niswender
Glutamate receptors as therapeutic targets for Parkinson's disease.
CNS & neurological disorders drug targets 2009;8(6):475-91.
2009: Jana K Shirey; Ashley E Brady; Paulianda J Jones; Albert A Davis; Thomas M Bridges; J Phillip Kennedy; Satyawan B Jadhav; Usha N Menon; Zixiu Xiang; Mona L Watson; Edward P Christian; James J Doherty; Michael C Quirk; Dean H Snyder; James J Lah; Allan Levey; Michelle M Nicolle; Craig W Lindsley; P Jeffrey Conn
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(45):14271-86.
2009: Mohammed N Tantawy; Carrie K Jones; Ronald M Baldwin; M Sib Ansari; P Jeffrey Conn; Robert M Kessler; Todd E Peterson
[(18)F]Fallypride dopamine D2 receptor studies using delayed microPET scans and a modified Logan plot.
Nuclear medicine and biology 2009;36(8):931-40.
2009: J Phillip Kennedy; Thomas M Bridges; Patrick R Gentry; John T Brogan; Alexander S Kane; Carrie K Jones; Ashley E Brady; Jana K Shirey; P Jeffrey Conn; Craig W Lindsley
Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor.
ChemMedChem 2009;4(10):1600-7.
2009: Richard Williams; Kari A Johnson; Patrick R Gentry; Colleen M Niswender; Charles D Weaver; P Jeffrey Conn; Craig W Lindsley; Corey R Hopkins
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
Bioorganic & medicinal chemistry letters 2009;19(17):4967-70.
2009: Douglas J Sheffler; Richard Williams; Thomas M Bridges; Zixiu Xiang; Alexander S Kane; Nellie E Byun; Satyawan Jadhav; Mathew M Mock; Fang Zheng; L Michelle Lewis; Carrie K Jones; Colleen M Niswender; Charles D Weaver; Craig W Lindsley; P Jeffrey Conn
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.
Molecular pharmacology 2009;76(2):356-68.
2009: Jennifer E Ayala; Yelin Chen; Jessica L Banko; Douglas J Sheffler; Richard Williams; Alexandra N Telk; Noreen L Watson; Zixiu Xiang; Yongqin Zhang; Paulianda J Jones; Craig W Lindsley; M Foster Olive; P Jeffrey Conn
mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(9):2057-71.
2009: Sameer Sharma; Jeffrey Kedrowski; Jerri M Rook; Randy L Smith; Carrie K Jones; Alice L Rodriguez; P Jeffrey Conn; Craig W Lindsley
Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines.
Journal of medicinal chemistry 2009;52(14):4103-6.
2009: Darren W Engers; Colleen M Niswender; C David Weaver; Satyawan Jadhav; Usha N Menon; Rocio Zamorano; P Jeffrey Conn; Craig W Lindsley; Corey R Hopkins
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).
Journal of medicinal chemistry 2009;52(14):4115-8.
2009: Alice L Rodriguez; Richard Williams; Ya Zhou; Stacey R Lindsley; Uyen Le; Mark D Grier; C David Weaver; P Jeffrey Conn; Craig W Lindsley
Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.
Bioorganic & medicinal chemistry letters 2009;19(12):3209-13.
2009: J Phillip Kennedy; P Jeffrey Conn; Craig W Lindsley
A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin.
Bioorganic & medicinal chemistry letters 2009;19(12):3204-8.
2009: Darren W Engers; Alice L Rodriguez; Richard Williams; Alexis S Hammond; Daryl Venable; Oluwatomi Oluwatola; Gary A Sulikowski; P Jeffrey Conn; Craig W Lindsley
Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273.
ChemMedChem 2009;4(4):505-11.
2009: P Jeffrey Conn; Carrie K Jones; Craig W Lindsley
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders.
Trends in pharmacological sciences 2009;30(3):148-55.
2009: Joy E Marlo; Colleen M Niswender; Emily L Days; Thomas M Bridges; Yun Xiang; Alice L Rodriguez; Jana K Shirey; Ashley E Brady; Tasha Nalywajko; Qingwei Luo; Cheryl A Austin; Michael Baxter Williams; Kwangho Kim; Richard Williams; Darren Orton; H Alex Brown; Craig W Lindsley; C David Weaver; P Jeffrey Conn
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.
Molecular pharmacology 2009;75(3):577-88.
2009: Richard Williams; Colleen M Niswender; Qingwei Luo; Uyen Le; P Jeffrey Conn; Craig W Lindsley
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead.
Bioorganic & medicinal chemistry letters 2009;19(3):962-6.
2009: C David Weaver; Douglas J Sheffler; L Michelle Lewis; Thomas M Bridges; Richard Williams; Natalia T Nalywajko; J Phillip Kennedy; Matthew M Mulder; Satyawan Jadhav; Leslie A Aldrich; Carrie K Jones; Joy E Marlo; Colleen M Niswender; Matthew M Mock; Fang Zheng; P Jeffrey Conn; Craig W Lindsley
Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe.
Current topics in medicinal chemistry 2009;9(13):1217-26.
2009: P Jeffrey Conn; Arthur Christopoulos; Craig W Lindsley
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
Nature reviews. Drug discovery 2009;8(1):41-54.
2009: P Jeffrey Conn; Craig W Lindsley; Carrie K Jones
Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.
Trends in pharmacological sciences 2009;30(1):25-31.
2008: Ashley E Brady; Carrie K Jones; Thomas M Bridges; J Phillip Kennedy; Analisa D Thompson; Justin U Heiman; Micah L Breininger; Patrick R Gentry; Huiyong Yin; Satyawan B Jadhav; Jana K Shirey; P Jeffrey Conn; Craig W Lindsley
Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats.
The Journal of pharmacology and experimental therapeutics 2008;327(3):941-53.
2008: Colleen M Niswender; Kari A Johnson; C David Weaver; Carrie K Jones; Zixiu Xiang; Qingwei Luo; Alice L Rodriguez; Joy E Marlo; Tomas de Paulis; Analisa D Thompson; Emily L Days; Tasha Nalywajko; Cheryl A Austin; Michael Baxter Williams; Jennifer E Ayala; Richard Williams; Craig W Lindsley; P Jeffrey Conn
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Molecular pharmacology 2008;74(5):1345-58.
2008: Nicole R Miller; R Nathan Daniels; Thomas M Bridges; Ashley E Brady; P Jeffrey Conn; Craig W Lindsley
Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen.
Bioorganic & medicinal chemistry letters 2008;18(20):5443-7.
2008: Thomas M Bridges; Ashley E Brady; J Phillip Kennedy; R Nathan Daniels; Nicole R Miller; Kwango Kim; Micah L Breininger; Patrick R Gentry; John T Brogan; Carrie K Jones; P Jeffrey Conn; Craig W Lindsley
Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.
Bioorganic & medicinal chemistry letters 2008;18(20):5439-42.
2008: Colleen M Niswender; Evan P Lebois; Qingwei Luo; Kwangho Kim; Hubert Muchalski; Huiyong Yin; P Jeffrey Conn; Craig W Lindsley
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators.
Bioorganic & medicinal chemistry letters 2008;18(20):5626-30.
2008: Carrie K Jones; Ashley E Brady; Albert A Davis; Zixiu Xiang; Michael Bubser; Mohammed Noor Tantawy; Alexander S Kane; Thomas M Bridges; J Phillip Kennedy; Stefania R Bradley; Todd E Peterson; M Sib Ansari; Ronald M Baldwin; Robert M Kessler; Ariel Deutch; James J Lah; Allan Levey; Craig W Lindsley; P Jeffrey Conn
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(41):10422-33.
2008: Douglas J Sheffler; P Jeffrey Conn
Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells.
Neuropharmacology 2008;55(4):419-27.
2008: Paulianda J Jones; Zixiu Xiang; P Jeffrey Conn
Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synapse.
Neuropharmacology 2008;55(4):440-6.
2008: P Jeffrey Conn; Bryan L Roth
Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(9):2048-60.
2008: Sameer Sharma; Alice L Rodriguez; P Jeffrey Conn; Craig W Lindsley
Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.
Bioorganic & medicinal chemistry letters 2008;18(14):4098-101.
2008: P Jeffrey Conn; Carol A Tamminga; Darryle D Schoepp; Craig W Lindsley
Schizophrenia: moving beyond monoamine antagonists.
Molecular interventions 2008;8(2):99-107.
2008: Jennifer E Ayala; Colleen M Niswender; Qingwei Luo; Jessica L Banko; P Jeffrey Conn
Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated.
Neuropharmacology 2008;54(5):804-14.
2008: Colleen M Niswender; Kari A Johnson; Qingwei Luo; Jennifer E Ayala; Caroline Kim; P Jeffrey Conn; C David Weaver
A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors.
Molecular pharmacology 2008;73(4):1213-24.
2008: Yelin Chen; Cyril Goudet; Jean-Philippe Pin; P Jeffrey Conn
N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
Molecular pharmacology 2008;73(3):909-18.
2008: L Michelle Lewis; Douglas Sheffler; Richard Williams; Thomas M Bridges; J Phillip Kennedy; J T Brogan; Matthew J Mulder; Lyndsey Williams; Natalia T Nalywajko; Colleen M Niswender; Charles D Weaver; P Jeffrey Conn; Craig W Lindsley
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.
Bioorganic & medicinal chemistry letters 2008;18(3):885-90.
2008: Jana K Shirey; Zixiu Xiang; Darren Orton; Ashley E Brady; Kari A Johnson; Richard Williams; Jennifer E Ayala; Alice L Rodriguez; Jürgen Wess; David Weaver; Colleen M Niswender; P Jeffrey Conn
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.
Nature chemical biology 2008;4(1):42-50.
2007: Olga V Poisik; Yoland Smith; P Jeffrey Conn
D1- and D2-like dopamine receptors regulate signaling properties of group I metabotropic glutamate receptors in the rat globus pallidus.
The European journal of neuroscience 2007;26(4):852-62.
2007: Michael A Benneyworth; Zixiu Xiang; Randy L Smith; Efrain E Garcia; P Jeffrey Conn; Elaine Sanders-Bush
A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.
Molecular pharmacology 2007;72(2):477-84.
2007: Kamondanai Hemstapat; Herve Da Costa; Yi Nong; Ashley E Brady; Qingwei Luo; Colleen M Niswender; Gilles Tamagnan; P Jeffrey Conn
A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.
The Journal of pharmacology and experimental therapeutics 2007;322(1):254-64.
2007: Yelin Chen; Yi Nong; Cyril Goudet; Kamondanai Hemstapat; Tomas de Paulis; Jean-Philippe Pin; P Jeffrey Conn
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Molecular pharmacology 2007;71(5):1389-98.
2007: Zhijian Zhao; David D Wisnoski; Julie A O'Brien; Wei Lemaire; David L Williams; Marlene A Jacobson; Marion Wittman; Sookhee N Ha; Hervé Schaffhauser; Cyrille Sur; Douglas J Pettibone; Mark E Duggan; P Jeffrey Conn; George D Hartman; Craig W Lindsley
Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
Bioorganic & medicinal chemistry letters 2007;17(5):1386-91.
2007: Craig W Lindsley; David Weaver; Carrie Jones; Lawrence J Marnett; P Jeffrey Conn
Preclinical drug discovery research and training at Vanderbilt.
ACS chemical biology 2007;2(1):17-20.
2006: Craig W Lindsley; Zhijian Zhao; William H Leister; Julie O'Brien; Wei Lemaire; David L Williams; Tsing-Bau Chen; Raymond S L Chang; Maryann Burno; Marlene A Jacobson; Cyrille Sur; Gene G Kinney; Douglas J Pettibone; Philip R Tiller; Sheri Smith; Nancy N Tsou; Mark E Duggan; P Jeffrey Conn; George D Hartman
Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.
ChemMedChem 2006;1(8):807-11.
2006: Kamondanai Hemstapat; Tomas de Paulis; Yelin Chen; Ashley E Brady; Vandana K Grover; David Alagille; Gilles Tamagnan; P Jeffrey Conn
A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Molecular pharmacology 2006;70(2):616-26.
2006: Ruggero Galici; Carrie K Jones; Kamondanai Hemstapat; Yi Nong; Nicholas G Echemendia; Lilly C Williams; Tomas de Paulis; P Jeffrey Conn
Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
The Journal of pharmacology and experimental therapeutics 2006;318(1):173-85.
2006: Tomas de Paulis; Kamondanai Hemstapat; Yelin Chen; Yongqin Zhang; Samir Saleh; David Alagille; Ronald M Baldwin; Gilles Tamagnan; P Jeffrey Conn
Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.
Journal of medicinal chemistry 2006;49(11):3332-44.
2006: Michael J Marino; P Jeffrey Conn
Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors.
Current opinion in pharmacology 2006;6(1):98-102.
2006: P Jeffrey Conn; Colleen M Niswender
mGluR7's lucky number.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(2):251-2.
2005: Alice L Rodriguez; Yi Nong; Nishant K Sekaran; David Alagille; Gilles Tamagnan; P Jeffrey Conn
A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators.
Molecular pharmacology 2005;68(6):1793-802.
2005: Yongqin Zhang; Alice L Rodriguez; P Jeffrey Conn
Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1212-9.
2005: Ruggero Galici; Nicholas G Echemendia; Alice L Rodriguez; P Jeffrey Conn
A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1181-7.
2005: P Jeffrey Conn; Giuseppe Battaglia; Michael J Marino; Ferdinando Nicoletti
Metabotropic glutamate receptors in the basal ganglia motor circuit.
Nature reviews. Neuroscience 2005;6(10):787-98.
2005: Ornella Valenti; Guido Mannaioni; Guy R Seabrook; P Jeffrey Conn; Michael J Marino
Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1296-304.
2005: Marion Wittmann; Michael J Marino; Darrell A Henze; Guy R Seabrook; P Jeffrey Conn
Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases.
The Journal of pharmacology and experimental therapeutics 2005;313(2):594-603.
2005: Gene G Kinney; Julie A O'Brien; Wei Lemaire; Maryann Burno; Denise J Bickel; Michelle K Clements; Tsing-Bau Chen; David D Wisnoski; Craig W Lindsley; Philip R Tiller; Sheri Smith; Marlene A Jacobson; Cyrille Sur; Mark E Duggan; Douglas J Pettibone; P Jeffrey Conn; David L Williams
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
The Journal of pharmacology and experimental therapeutics 2005;313(1):199-206.
2005: Colleen M Niswender; Carrie K Jones; P Jeffrey Conn
New therapeutic frontiers for metabotropic glutamate receptors.
Current topics in medicinal chemistry 2005;5(9):847-57.
2005: Sudar Alagarsamy; Julie A Saugstad; Lee Warren; Isabelle M Mansuy; Robert W Gereau; P Jeffrey Conn
NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin.
Neuropharmacology 2005;49 Suppl 1():135-45.
2005: Olga V Poisik; nitin raju; Marc Verreault; Alice Rodriguez; Oluseyi A Abeniyi; P Jeffrey Conn; Yoland Smith
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.
Neuropharmacology 2005;49 Suppl 1():57-69.
2004: James J Doherty; Sudar Alagarsamy; Kristopher Bough; P Jeffrey Conn; ray dingledine; David D Mott
Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus.
The Journal of physiology 2004;561(Pt 2):395-401.
2004: Craig W Lindsley; David D Wisnoski; William H Leister; Julie A O'Brien; Wei Lemaire; David L Williams; Maryann Burno; Cyrille Sur; Gene G Kinney; Douglas J Pettibone; Philip R Tiller; Sheri Smith; Mark E Duggan; George D Hartman; P Jeffrey Conn; Joel R Huff
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
Journal of medicinal chemistry 2004;47(24):5825-8.
2004: Una C Campbell; Kush Lalwani; Lisa Hernandez; Gene G Kinney; P Jeffrey Conn; Linda J Bristow
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.
Psychopharmacology 2004;175(3):310-8.
2004: Julie A O'Brien; Wei Lemaire; Marion Wittmann; Marlene A Jacobson; Sookhee N Ha; David D Wisnoski; Craig W Lindsley; Hervé Schaffhauser; Blake Rowe; Cyrille Sur; Mark E Duggan; Douglas J Pettibone; P Jeffrey Conn; David L Williams
A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.
The Journal of pharmacology and experimental therapeutics 2004;309(2):568-77.
2003: Cyrille Sur; Pierre J Mallorga; Marion Wittmann; Marlene A Jacobson; Danette Pascarella; Jacinta B Williams; Philip E Brandish; Douglas J Pettibone; Edward M Scolnick; P Jeffrey Conn
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13674-9.
2003: Michael J Marino; David L Williams; Julie A O'Brien; Ornella Valenti; Terrence P McDonald; Michelle K Clements; Ruiping Wang; Anthony G DiLella; J Fred Hess; Gene G Kinney; P Jeffrey Conn
Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13668-73.
2003: David L Williams; Julie A O'Brien; Wei Lemaire; Tsing-Bau Chen; Raymond S L Chang; Marlene A Jacobson; Sookhee N Ha; David D Wisnoski; Craig W Lindsley; Cyrille Sur; Mark E Duggan; Douglas J Pettibone; P Jeffrey Conn
Difference in mGluR5 interaction between positive allosteric modulators from two structural classes.
Annals of the New York Academy of Sciences 2003;1003():481-4.
2003: Ornella Valenti; Michael J Marino; P Jeffrey Conn
Modulation of excitatory transmission onto midbrain dopaminergic neurons of the rat by activation of group III metabotropic glutamate receptors.
Annals of the New York Academy of Sciences 2003;1003():479-80.
2003: Michael J Marino; Ornella Valenti; Julie A O'Brien; David L Williams; P Jeffrey Conn
Modulation of inhibitory transmission in the rat globus pallidus by activation of mGluR4.
Annals of the New York Academy of Sciences 2003;1003():435-7.
2003: P Jeffrey Conn
Physiological roles and therapeutic potential of metabotropic glutamate receptors.
Annals of the New York Academy of Sciences 2003;1003():12-21.
2003: Candice E Junge; Taku Sugawara; Guido Mannaioni; Sudar Alagarsamy; P Jeffrey Conn; Daniel J Brat; Pak H Chan; Stephen F Traynelis
The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13019-24.
2003: Pierre J Mallorga; Jacinta B Williams; Marlene Jacobson; Rosemary Marques; Ashok Chaudhary; P Jeffrey Conn; Douglas J Pettibone; Cyrille Sur
Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.
Neuropharmacology 2003;45(5):585-93.
2003: Julie A O'Brien; Wei Lemaire; Tsing-Bau Chen; Raymond S L Chang; Marlene A Jacobson; Sookhee N Ha; Craig W Lindsley; Hervé Schaffhauser; Cyrille Sur; Douglas J Pettibone; P Jeffrey Conn; David L Williams
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
Molecular pharmacology 2003;64(3):731-40.
2003: Gene G Kinney; Cyrille Sur; Maryann Burno; Pierre J Mallorga; Jacinta B Williams; David Figueroa; Marion Wittmann; Wei Lemaire; P Jeffrey Conn
The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(20):7586-91.
2003: Ornella Valenti; Michael J Marino; Marion Wittmann; Edward V Lis; Anthony G DiLella; Gene G Kinney; P Jeffrey Conn
Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(18):7218-26.
2003: Gene G Kinney; Maryann Burno; Una C Campbell; Lisa M Hernandez; Dana Rodriguez; Linda J Bristow; P Jeffrey Conn
Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents.
The Journal of pharmacology and experimental therapeutics 2003;306(1):116-23.
2003: Scott D Sorensen; P Jeffrey Conn
G protein-coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression.
Neuropharmacology 2003;44(6):699-706.
2003: Michael J Marino; Ornella Valenti; P Jeffrey Conn
Glutamate receptors and Parkinson's disease: opportunities for intervention.
Drugs & aging 2003;20(5):377-97.
2003: Olga V Poisik; Guido Mannaioni; Stephen F Traynelis; Yoland Smith; P Jeffrey Conn
Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(1):122-30.
2002: D D Schoepp; P Jeffrey Conn
Metabotropic glutamate receptors.
Pharmacology, biochemistry, and behavior 2002;74(1):255-6.
2002: Richard D Peavy; Scott D Sorensen; P Jeffrey Conn
Differential regulation of metabotropic glutamate receptor 5-mediated phosphoinositide hydrolysis and extracellular signal-regulated kinase responses by protein kinase C in cultured astrocytes.
Journal of neurochemistry 2002;83(1):110-8.
2002: Sudar Alagarsamy; Susan T Rouse; Candice E Junge; George W Hubert; David Gutman; Yoland Smith; P Jeffrey Conn
NMDA-induced phosphorylation and regulation of mGluR5.
Pharmacology, biochemistry, and behavior 2002;73(2):299-306.
2002: Michael J Marino; H Awad-Granko; K J Ciombor; P Jeffrey Conn
Haloperidol-induced alteration in the physiological actions of group I mGlus in the subthalamic nucleus and the substantia nigra pars reticulata.
Neuropharmacology 2002;43(2):147-59.
2002: Marion Wittmann; Michael J Marino; P Jeffrey Conn
Dopamine modulates the function of group II and group III metabotropic glutamate receptors in the substantia nigra pars reticulata.
The Journal of pharmacology and experimental therapeutics 2002;302(2):433-41.
2002: Gilbert Besong; Giuseppe Battaglia; Mara D'Onofrio; Roberto Di Marco; Richard Teke Ngomba; marianna storto; Marzia Castiglione; Katia Mangano; Carla L Busceti; Ferdinando R Nicoletti; Kevin Bacon; Michael Tusche; Ornella Valenti; P Jeffrey Conn; Valeria Bruno; Ferdinando Nicoletti
Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(13):5403-11.
2002: Scott D Sorensen; Thomas A Macek; Zhaohui Cai; Julie A Saugstad; P Jeffrey Conn
Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function.
Molecular pharmacology 2002;61(6):1303-12.
2002: Ornella Valenti; P Jeffrey Conn; Michael J Marino
Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors Co-expressed in the same neuronal populations.
Journal of cellular physiology 2002;191(2):125-37.
2002: Julie A Saugstad; Sufang Yang; jan pohl; Randy A Hall; P Jeffrey Conn
Interaction between metabotropic glutamate receptor 7 and alpha tubulin.
Journal of neurochemistry 2002;80(6):980-8.
2002: Michael J Marino; P Jeffrey Conn
Direct and indirect modulation of the N-methyl D-aspartate receptor.
Current drug targets. CNS and neurological disorders 2002;1(1):1-16.
2002: Michael J Marino; H Awad; Olga V Poisik; Marion Wittmann; P Jeffrey Conn
Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia.
Amino acids 2002;23(1-3):185-91.
2001: Richard D Peavy; M S Chang; E Sanders-Bush; P Jeffrey Conn
Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(24):9619-28.
2001: Michael J Marino; Marion Wittmann; SR Bradley; George W Hubert; Yoland Smith; P Jeffrey Conn
Activation of group I metabotropic glutamate receptors produces a direct excitation and disinhibition of GABAergic projection neurons in the substantia nigra pars reticulata.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(18):7001-12.
2001: F Zheng; Kevin Erreger; Chian-Ming Low; Tue G Banke; C Justin Lee; P Jeffrey Conn; Stephen F Traynelis
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A.
Nature neuroscience 2001;4(9):894-901.
2001: Guido Mannaioni; Michael J Marino; Ornella Valenti; Stephen F Traynelis; P Jeffrey Conn
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(16):5925-34.
2001: Zhaohui Cai; Julie A Saugstad; Scott D Sorensen; K J Ciombor; C Zhang; H Schaffhauser; Frantisek Hubalek; jan pohl; Robert M Duvoisin; P Jeffrey Conn
Cyclic AMP-dependent protein kinase phosphorylates group III metabotropic glutamate receptors and inhibits their function as presynaptic receptors.
Journal of neurochemistry 2001;78(4):756-66.
2001: H Awad-Granko; P Jeffrey Conn
Activation of groups I or III metabotropic glutamate receptors inhibits excitatory transmission in the rat subthalamic nucleus.
Neuropharmacology 2001;41(1):32-41.
2001: Sudar Alagarsamy; Scott D Sorensen; P Jeffrey Conn
Coordinate regulation of metabotropic glutamate receptors.
Current opinion in neurobiology 2001;11(3):357-62.
2001: Marion Wittmann; Michael J Marino; SR Bradley; P Jeffrey Conn
Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata.
Journal of neurophysiology 2001;85(5):1960-8.
2001: Marion Wittmann; George W Hubert; Yoland Smith; P Jeffrey Conn
Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata.
Neuroscience 2001;105(4):881-9.
2000: H C Prince; A V Tzingounis; Allan Levey; P Jeffrey Conn
Functional downregulation of GluR2 in piriform cortex of kindled animals.
Synapse (New York, N.Y.) 2000;38(4):489-98.
2000: Susan T Rouse; Michael J Marino; SR Bradley; H Awad; Marion Wittmann; P Jeffrey Conn
Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders.
Pharmacology & therapeutics 2000;88(3):427-35.
2000: H Awad; George W Hubert; Yoland Smith; Allan Levey; P Jeffrey Conn
Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(21):7871-9.
2000: H Schaffhauser; Zhaohui Cai; Frantisek Hubalek; Thomas A Macek; jan pohl; Thomas J Murphy; P Jeffrey Conn
cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(15):5663-70.
2000: SR Bradley; Michael J Marino; Marion Wittmann; Susan T Rouse; H Awad; Allan Levey; P Jeffrey Conn
Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of the substantia Nigra pars reticulata.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3085-94.
2000: ray dingledine; P Jeffrey Conn
Peripheral glutamate receptors: molecular biology and role in taste sensation.
The Journal of nutrition 2000;130(4S Suppl):1039S-42S.
2000: Susan T Rouse; Susan E Hamilton; LT Potter; Neil M Nathanson; P Jeffrey Conn
Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors.
Neuroscience letters 2000;278(1-2):61-4.
1999: Thomas A Macek; H Schaffhauser; P Jeffrey Conn
Activation of PKC disrupts presynaptic inhibition by group II and group III metabotropic glutamate receptors and uncouples the receptor from GTP-binding proteins.
Annals of the New York Academy of Sciences 1999;868():554-7.
1999: SR Bradley; David G Standaert; Allan Levey; P Jeffrey Conn
Distribution of group III mGluRs in rat basal ganglia with subtype-specific antibodies.
Annals of the New York Academy of Sciences 1999;868():531-4.
1999: Sudar Alagarsamy; Susan T Rouse; Robert W Gereau; Stephen F Heinemann; Yoland Smith; P Jeffrey Conn
Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems.
Annals of the New York Academy of Sciences 1999;868():526-30.
1999: SR Bradley; David G Standaert; K J Rhodes; Howard D Rees; C M Testa; Allan Levey; P Jeffrey Conn
Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia.
The Journal of comparative neurology 1999;407(1):33-46.
1999: Sudar Alagarsamy; Michael J Marino; Susan T Rouse; Robert W Gereau; Stephen F Heinemann; P Jeffrey Conn
Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems.
Nature neuroscience 1999;2(3):234-40.
1999: Meredith Hay; H McKenzie; K Lindsley; N Dietz; SR Bradley; P Jeffrey Conn; Eileen M Hasser
Heterogeneity of metabotropic glutamate receptors in autonomic cell groups of the medulla oblongata of the rat.
The Journal of comparative neurology 1999;403(4):486-501.
1999: W Paradee; H E Melikian; D L Rasmussen; A Kenneson; P Jeffrey Conn; Stephen Warren
Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function.
Neuroscience 1999;94(1):185-92.
1999: Susan T Rouse; Michael J Marino; LT Potter; P Jeffrey Conn; Allan Levey
Muscarinic receptor subtypes involved in hippocampal circuits.
Life sciences 1999;64(6-7):501-9.
1999: Xavier Khawaja; Jin-Jun Liang; Julie A Saugstad; Philip G Jones; S Harnish; P Jeffrey Conn; Mark Cockett
Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Galphaq proteins in the adult rat brain.
Journal of neurochemistry 1999;72(1):174-84.
1998: Michael J Marino; Susan T Rouse; Allan Levey; LT Potter; P Jeffrey Conn
Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11465-70.
1998: Thomas A Macek; H Schaffhauser; P Jeffrey Conn
Protein kinase C and A3 adenosine receptor activation inhibit presynaptic metabotropic glutamate receptor (mGluR) function and uncouple mGluRs from GTP-binding proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(16):6138-46.
1998: SR Bradley; Howard D Rees; Hong Yi; Allan Levey; P Jeffrey Conn
Distribution and developmental regulation of metabotropic glutamate receptor 7a in rat brain.
Journal of neurochemistry 1998;71(2):636-45.
1998: Richard D Peavy; P Jeffrey Conn
Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors.
Journal of neurochemistry 1998;71(2):603-12.
1998: F Zheng; Melissa B Gingrich; Stephen F Traynelis; P Jeffrey Conn
Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition.
Nature neuroscience 1998;1(3):185-91.
1998: Julie A Saugstad; Michael J Marino; J A Folk; John R Hepler; P Jeffrey Conn
RGS4 inhibits signaling by group I metabotropic glutamate receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(3):905-13.
1997: D S Chung; Stephen F Traynelis; Thomas J Murphy; P Jeffrey Conn
4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis.
The Journal of pharmacology and experimental therapeutics 1997;283(2):742-9.
1997: H P Miller; Allan Levey; Jeffrey rothstein; A V Tzingounis; P Jeffrey Conn
Alterations in glutamate transporter protein levels in kindling-induced epilepsy.
Journal of neurochemistry 1997;68(4):1564-70.
1997: P Jeffrey Conn; J P Pin
Pharmacology and functions of metabotropic glutamate receptors.
Annual review of pharmacology and toxicology 1997;37():205-37.
1996: Thomas A Macek; D G Winder; Robert W Gereau; C O Ladd; P Jeffrey Conn
Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses.
Journal of neurophysiology 1996;76(6):3798-806.
1996: D G Winder; P Jeffrey Conn
Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication.
Journal of neuroscience research 1996;46(2):131-7.
1996: D G Winder; P S Ritch; Robert W Gereau; P Jeffrey Conn
Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus.
The Journal of physiology 1996;494 ( Pt 3)():743-55.
1996: SR Bradley; Allan Levey; Steven M Hersch; P Jeffrey Conn
Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(6):2044-56.
1995: Robert W Gereau; P Jeffrey Conn
Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(10):6879-89.
1995: Robert W Gereau; P Jeffrey Conn
Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability.
Journal of neurophysiology 1995;74(1):122-9.
1995: Robert W Gereau; D G Winder; P Jeffrey Conn
Pharmacological differentiation of the effects of co-activation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus.
Neuroscience letters 1995;186(2-3):119-22.
1995: D G Winder; P Jeffrey Conn
Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR.
Journal of neurochemistry 1995;64(2):592-9.
1995: H K Prince; P Jeffrey Conn; C D Blackstone; Richard Huganir; Allan Levey
Down-regulation of AMPA receptor subunit GluR2 in amygdaloid kindling.
Journal of neurochemistry 1995;64(1):462-5.
1994: M A Desai; C J McBain; Julie A Kauer; P Jeffrey Conn
Metabotropic glutamate receptor-induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells.
Neuroscience letters 1994;181(1-2):78-82.
1994: Robert W Gereau; P Jeffrey Conn
Presynaptic enhancement of excitatory synaptic transmission by beta-adrenergic receptor activation.
Journal of neurophysiology 1994;72(3):1438-42.
1994: D S Chung; D G Winder; P Jeffrey Conn
4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane-1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices.
Journal of neurochemistry 1994;63(1):133-9.
1994: Valerie Boss; K M Nutt; P Jeffrey Conn
L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.
Molecular pharmacology 1994;45(6):1177-82.
1994: Robert W Gereau; P Jeffrey Conn
Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism.
Neuron 1994;12(5):1121-9.
1994: Robert W Gereau; P Jeffrey Conn
A cyclic AMP-dependent form of associative synaptic plasticity induced by coactivation of beta-adrenergic receptors and metabotropic glutamate receptors in rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(5 Pt 2):3310-8.
1993: D G Winder; T Smith; P Jeffrey Conn
Pharmacological differentiation of metabotropic glutamate receptors coupled to potentiation of cyclic adenosine monophosphate responses and phosphoinositide hydrolysis.
The Journal of pharmacology and experimental therapeutics 1993;266(2):518-25.
1993: D G Winder; P Jeffrey Conn
Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(1):38-44.
1992: Valerie Boss; P Jeffrey Conn
Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices.
Journal of neurochemistry 1992;59(6):2340-3.
1992: S J Chen; M A Desai; Eric Klann; D G Winder; J David Sweatt; P Jeffrey Conn
Amygdala kindling alters protein kinase C activity in dentate gyrus.
Journal of neurochemistry 1992;59(5):1761-9.
1992: M A Desai; T S Smith; P Jeffrey Conn
Multiple metabotropic glutamate receptors regulate hippocampal function.
Synapse (New York, N.Y.) 1992;12(3):206-13.
1992: Valerie Boss; M A Desai; T S Smith; P Jeffrey Conn
Trans-ACPD-induced phosphoinositide hydrolysis and modulation of hippocampal pyramidal cell excitability do not undergo parallel developmental regulation.
Brain research 1992;594(2):181-8.
1992: D G Winder; P Jeffrey Conn
Activation of metabotropic glutamate receptors in the hippocampus increases cyclic AMP accumulation.
Journal of neurochemistry 1992;59(1):375-8.
1991: M A Desai; P Jeffrey Conn
Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition.
Journal of neurophysiology 1991;66(1):40-52.
1990: M A Desai; P Jeffrey Conn
Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate.
Neuroscience letters 1990;109(1-2):157-62.