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Thomas Bugge

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Constantinos M Mikelis; Yoh-suke Mukouyama; Todd R Palmby; May Simaan; Roman Szabo; Hiroshi Yagi; Thomas H Bugge; Hiroki Chikumi; Shigetomo Fukuhara; Rebeca Galisteo; Wenling Li; Ruth Lyons; Daniel Martin; J Silvio Gutkind
PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation.
Brian R Larsen; Chen-Yong Lin; Nis V L Nielsen; Annika W Nonboe; Steen S Poulsen; Hanne Skovbjerg; Christoffer Soendergaard; Simon D R Steffensen; Roman Szabo; Martin N Andersen; Jette Bornholdt; Thomas H Bugge; Stine Friis; Sine Godiksen; Jan K Jensen; Lotte K Vogel
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase.
P Kosa; Alfredo A Molinolo; Roman Szabo; Thomas H Bugge
Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis.

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2013: Constantinos M Mikelis; Yoh-suke Mukouyama; Todd R Palmby; May Simaan; Roman Szabo; Hiroshi Yagi; Thomas H Bugge; Hiroki Chikumi; Shigetomo Fukuhara; Rebeca Galisteo; Wenling Li; Ruth Lyons; Daniel Martin; J Silvio Gutkind
PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation.
The Journal of biological chemistry 2013;288(17):12232-43.
2013: Brian R Larsen; Chen-Yong Lin; Nis V L Nielsen; Annika W Nonboe; Steen S Poulsen; Hanne Skovbjerg; Christoffer Soendergaard; Simon D R Steffensen; Roman Szabo; Martin N Andersen; Jette Bornholdt; Thomas H Bugge; Stine Friis; Sine Godiksen; Jan K Jensen; Lotte K Vogel
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase.
Experimental cell research 2013;319(6):918-29.
2012: P Kosa; Alfredo A Molinolo; Roman Szabo; Thomas H Bugge
Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis.
Oncogene 2012;31(32):3679-95.
2012: Sarah Netzel-Arnett; Terez Shea-Donohue; Thomas H Bugge; Marguerite S Buzza; Antoine Désilets; Alessio Fasano; Richard Leduc; Toni M Antalis
Matriptase protects against experimental colitis and promotes intestinal barrier recovery.
Inflammatory bowel diseases 2012;18(7):1303-14.
2012: Diane E Peters; Roman Szabo; Yi Zhang; Thomas H Bugge; Stephen H Leppla; Sharmina Miller-Randolph; Alfredo A Molinolo; Shihui Liu
Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis.
Biochemical and biophysical research communications 2012;422(3):393-7.
2012: Daniel H Madsen; Maria C Melander; Birgitte Rønø; Ben Vainer; Thomas H Bugge; Kristoffer Lihme Egerod; Lars H Engelholm; Andreas Hald; Signe Ingvarsen; Henrik J Jürgensen; Charlotte A Madsen; Niels Behrendt
Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis.
The Journal of pathology 2012;227(1):94-105.
2012: Nisan Bhattacharyya; Thomas H Bugge; Natasha Cherman; Monique Cho; Brian M Connolly; Claudia Dumitrescu; Rachel I Gafni; Gordon L Hager; Himatkumar V Patel; Malgorzata Wiench; Michael T Collins
Mechanism of FGF23 processing in fibrous dysplasia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(5):1132-41.
2012: Roman Szabo; Katiuchia Uzzun Sales; Lotte K Vogel; Eric Camerer; Stine Friis; Sine Godiksen; J Silvio Gutkind; Karina K Hansen; Edith Hummler; Peter Kosa; Natalia A Shylo; Thomas H Bugge
Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.
PLoS genetics 2012;8(8):e1002937.
2011: Andrius Masedunskas; Laura Parente; Katiuchia Uzzun Sales; Monika Sramkova; Panomwat Amornphimoltham; Thomas H Bugge; Roberto Weigert
Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13552-7.
2011: Daniel H Madsen; Maria C Melander; Amanda Moyer; Niels Behrendt; Thomas H Bugge; Sven Burgdorf; Peter Garred; Christian Honoré; Signe Ingvarsen; Henrik J Jürgensen; Lars Kjøller; Charlotte A Madsen; Lars H Engelholm
The non-phagocytic route of collagen uptake: a distinct degradation pathway.
The Journal of biological chemistry 2011;286(30):26996-7010.
2011: Roman Szabo; A L Rasmussen; A B Moyer; P Kosa; J M Schafer; Alfredo A Molinolo; J Silvio Gutkind; Thomas H Bugge
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase.
Oncogene 2011;30(17):2003-16.
2011: Stine Friis; Sine Godiksen; Jette Bornholdt; Joanna Selzer-Plon; Hanne B Rasmussen; Thomas H Bugge; Chen-Yong Lin; Lotte K Vogel
Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase.
The Journal of biological chemistry 2011;286(7):5793-802.
2011: Katiuchia Uzzun Sales; Maham F Shah; Roman Szabo; Rebecca Wagenaar-Miller; Alexandra Bey; John P Hobson; Alfredo A Molinolo; Amber L Rasmussen; Thomas H Bugge
Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.
PloS one 2011;6(8):e23261.
2011: Roman Szabo; Thomas H Bugge
Membrane-anchored serine proteases in vertebrate cell and developmental biology.
Annual review of cell and developmental biology 2011;27():213-35.
2011: Jeffrey M Schafer; Stephen H Leppla; Shihui Liu; Alfredo A Molinolo; Thomas Morley; Diane E Peters; Thomas H Bugge
Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin.
PloS one 2011;6(5):e20532.
2011: Toni M Antalis; Thomas H Bugge; Qingyu Wu
Membrane-anchored serine proteases in health and disease.
Progress in molecular biology and translational science 2011;99():1-50.
2010: Brian M Connolly; Eun Young Choi; Henrik Gårdsvoll; Alexandra L Bey; Brooke M Currie; Triantafyllos Chavakis; Shihui Liu; Alfredo A Molinolo; Michael Ploug; Stephen H Leppla; Thomas H Bugge
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation.
Blood 2010;116(9):1593-603.
2010: Katiuchia Uzzun Sales; Andrius Masedunskas; Alexandra L Bey; Amber L Rasmussen; Roberto Weigert; Karin List; Roman Szabo; Paul A Overbeek; Thomas H Bugge
Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome.
Nature genetics 2010;42(8):676-83.
2010: Marguerite S Buzza; Sarah Netzel-Arnett; Terez Shea-Donohue; Aiping Zhao; Chen-Yong Lin; Karin List; Roman Szabo; Alessio Fasano; Thomas H Bugge; Toni M Antalis
Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4200-5.
2010: Cristiane Helena Squarize; Rogerio M Castilho; Thomas H Bugge; J Silvio Gutkind
Accelerated wound healing by mTOR activation in genetically defined mouse models.
PloS one 2010;5(5):e10643.
2010: Satoru Takahashi; Toshio Ohshima; Motoyuki Hirasawa; Tej K Pareek; Thomas H Bugge; Alexei Morozov; Kenji Fujieda; Roscoe O Brady; Ashok Kulkarni
Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.
The American journal of pathology 2010;176(1):320-9.
2009: Sarah Netzel-Arnett; Thomas H Bugge; Rex Allen Hess; Kay Carnes; Brett W Stringer; Anthony L Scarman; John D Hooper; Ian D Tonks; Graham F Kay; Toni M Antalis
The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability.
Biology of reproduction 2009;81(5):921-32.
2009: Karin List; Peter Kosa; Roman Szabo; Alexandra L Bey; Chao Becky Wang; Alfredo A Molinolo; Thomas H Bugge
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.
The American journal of pathology 2009;175(4):1453-63.
2009: Thomas H Bugge; Toni M Antalis; Qingyu Wu
Type II transmembrane serine proteases.
The Journal of biological chemistry 2009;284(35):23177-81.
2009: Roman Szabo; John P Hobson; Kristina Christoph; Peter Kosa; Karin List; Thomas H Bugge
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.
Development (Cambridge, England) 2009;136(15):2653-63.
2009: Roman Szabo; Peter Kosa; Karin List; Thomas H Bugge
Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality.
The American journal of pathology 2009;174(6):2015-22.
2009: Shihui Liu; Thomas H Bugge; Arthur E Frankel; Stephen H Leppla
Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.
Methods in molecular biology (Clifton, N.J.) 2009;539():175-90.
2008: Roman Szabo; John P Hobson; Karin List; Alfredo A Molinolo; Chen-Yong Lin; Thomas H Bugge
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity.
The Journal of biological chemistry 2008;283(43):29495-504.
2008: Kirsty A Green; Kasper Almholt; Michael Ploug; Birgitte Rønø; Francis J Castellino; Morten Johnsen; Thomas H Bugge; John Rømer; Leif R Lund
Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.
The Journal of investigative dermatology 2008;128(8):2092-101.
2008: Sine Godiksen; Joanna Selzer-Plon; Esben D K Pedersen; Kathrine Abell; Hanne B Rasmussen; Roman Szabo; Thomas H Bugge; Lotte K Vogel
Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary.
The Biochemical journal 2008;413(2):251-9.
2008: Shihui Liu; Hailun Wang; Brooke M Currie; Alfredo A Molinolo; Howard J Leung; Mahtab Moayeri; John Basile; Randall W Alfano; J Silvio Gutkind; Arthur E Frankel; Thomas H Bugge; Stephen H Leppla
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature.
The Journal of biological chemistry 2008;283(1):529-40.
2008: Roman Szabo; Thomas H Bugge
Type II transmembrane serine proteases in development and disease.
The international journal of biochemistry & cell biology 2008;40(6-7):1297-316.
2007: Karin List; Brooke Currie; Tiffany C Scharschmidt; Roman Szabo; Jessica Shireman; Alfredo A Molinolo; Benjamin F Cravatt; Julia A Segre; Thomas H Bugge
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.
The Journal of biological chemistry 2007;282(50):36714-23.
2007: Karin List; John P Hobson; Alfredo A Molinolo; Thomas H Bugge
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.
Journal of cellular physiology 2007;213(1):237-45.
2007: Daniel H Madsen; Lars H Engelholm; Signe Ingvarsen; Thore Hillig; Rebecca Wagenaar-Miller; Lars Kjøller; Henrik Gårdsvoll; Gunilla Høyer-Hansen; Kenn Holmbeck; Thomas H Bugge; Niels Behrendt
Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.
The Journal of biological chemistry 2007;282(37):27037-45.
2007: Rebecca Wagenaar-Miller; Lars H Engelholm; Julie Gavard; Susan S Yamada; J Silvio Gutkind; Niels Behrendt; Thomas H Bugge; Kenn Holmbeck
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.
Molecular and cellular biology 2007;27(18):6309-22.
2007: Jay L Degen; Thomas H Bugge; Jon Goguen
Fibrin and fibrinolysis in infection and host defense.
Journal of thrombosis and haemostasis : JTH 2007;5 Suppl 1():24-31.
2007: Jay Sulek; Rebecca Wagenaar-Miller; Jessica Shireman; Alfredo A Molinolo; Daniel H Madsen; Lars H Engelholm; Niels Behrendt; Thomas H Bugge
Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(4):347-53.
2007: Roman Szabo; Alfredo A Molinolo; Karin List; Thomas H Bugge
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development.
Oncogene 2007;26(11):1546-56.
2007: John Basile; Kenn Holmbeck; Thomas H Bugge; J Silvio Gutkind
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.
The Journal of biological chemistry 2007;282(9):6899-905.
2007: Thomas H Bugge; Karin List; Roman Szabo
Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis.
Frontiers in bioscience : a journal and virtual library 2007;12():5060-70.
2006: Sarah Netzel-Arnett; Brooke M Currie; Roman Szabo; Chen-Yong Lin; Li-Mei Chen; Karl X Chai; Toni M Antalis; Thomas H Bugge; Karin List
Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation.
The Journal of biological chemistry 2006;281(44):32941-5.
2006: Karin List; Roman Szabo; Alfredo A Molinolo; Boye Nielsen; Thomas H Bugge
Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis.
The American journal of pathology 2006;168(5):1513-25.
2006: John P Hobson; Shihui Liu; Birgitte Rønø; Stephen H Leppla; Thomas H Bugge
Imaging specific cell-surface proteolytic activity in single living cells.
Nature methods 2006;3(4):259-61.
2006: Karin List; Thomas H Bugge; Roman Szabo
Matriptase: potent proteolysis on the cell surface.
Molecular medicine (Cambridge, Mass.) 2006;12(1-3):1-7.
2006: Birgitte Rønø; John Rømer; Shihui Liu; Thomas H Bugge; Stephen H Leppla; Paul E.G. Kristjansen
Antitumor efficacy of a urokinase activation-dependent anthrax toxin.
Molecular cancer therapeutics 2006;5(1):89-96.
2005: Sergey Filippov; Gerald C Koenig; Tae-Hwa Chun; Kevin B Hotary; Ichiro Ota; Thomas H Bugge; Joseph D Roberts; William P Fay; Henning Birkedal-Hansen; Kenn Holmbeck; Farideh Sabeh; Edward D Allen; Stephen J Weiss
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells.
The Journal of experimental medicine 2005;202(5):663-71.
2005: Karin List; Roman Szabo; Alfredo A Molinolo; Virote Sriuranpong; Vivien Redeye; Tricia Murdock; Beth Burke; Boye Nielsen; J Silvio Gutkind; Thomas H Bugge
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.
Genes & development 2005;19(16):1934-50.
2005: Roman Szabo; Sarah Netzel-Arnett; John P Hobson; Toni M Antalis; Thomas H Bugge
Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity.
The Biochemical journal 2005;390(Pt 1):231-42.
2005: Alejandro Curino; Lars H Engelholm; Susan S Yamada; Kenn Holmbeck; Leif R Lund; Alfredo A Molinolo; Niels Behrendt; Boye Nielsen; Thomas H Bugge
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.
The Journal of cell biology 2005;169(6):977-85.
2005: Shihui Liu; Vivien Redeye; Jeffrey G Kuremsky; Marissa Kuhnen; Alfredo A Molinolo; Thomas H Bugge; Stephen H Leppla
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin.
Nature biotechnology 2005;23(6):725-30.
2005: Toni M Antalis; Thomas H Bugge; Daniel Lawrence; Sarah Netzel-Arnett; Bradford S. Schwartz; Dudley K Strickland
Amalfi to Washington D. C.--twenty years of plasminogen activator research.
Thrombosis and haemostasis 2005;93(4):625-6.
2005: Benedict Law; Jong-Kai Hsiao; Thomas H Bugge; Ralph Weissleder; Ching-Hsuan Tung
Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples.
Analytical biochemistry 2005;338(1):151-8.
2004: John P Hobson; Sarah Netzel-Arnett; Roman Szabo; Sophie M Réhault; Frank Church; Dudley K Strickland; Daniel Lawrence; Toni M Antalis; Thomas H Bugge
Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes.
The Journal of biological chemistry 2004;279(45):46981-94.
2004: Alejandro Curino; Vyomesh Patel; Boye Nielsen; Andrew Iskander; John F Ensley; George H Yoo; F Christopher Holsinger; Jeffrey N Myers; Adel El-Nagaar; Robert M Kellman; Edward J Shillitoe; Alfredo A Molinolo; J Silvio Gutkind; Thomas H Bugge
Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography.
Oral oncology 2004;40(10):1026-32.
2004: Lars Kjøller; Lars H Engelholm; Maria Høyer-Hansen; Keld Danø; Thomas H Bugge; Niels Behrendt
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.
Experimental cell research 2004;293(1):106-16.
2004: Benedict Law; Alejandro Curino; Thomas H Bugge; Ralph Weissleder; Ching-Hsuan Tung
Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter.
Chemistry & biology 2004;11(1):99-106.
2003: Alexandra Makarova; Irina Mikhailenko; Thomas H Bugge; Karin List; Daniel Lawrence; Dudley K Strickland
The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes.
The Journal of biological chemistry 2003;278(50):50250-8.
2003: Karin List; Roman Szabo; Philip W Wertz; Julia A Segre; Christian Haudenschild; Soo-Youl Kim; Thomas H Bugge
Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.
The Journal of cell biology 2003;163(4):901-10.
2003: Manuel Yepes; maria sandkvist; Elizabeth G Moore; Thomas H Bugge; Dudley K Strickland; Daniel Lawrence
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.
The Journal of clinical investigation 2003;112(10):1533-40.
2003: Roman Szabo; Qingyu Wu; Robert B Dickson; Sarah Netzel-Arnett; Toni M Antalis; Thomas H Bugge
Type II transmembrane serine proteases.
Thrombosis and haemostasis 2003;90(2):185-93.
2003: Shihui Liu; Rebecca L Schubert; Thomas H Bugge; Stephen H Leppla
Anthrax toxin: structures, functions and tumour targeting.
Expert opinion on biological therapy 2003;3(5):843-53.
2003: Tanja Xenia Pedersen; Chidchanop Leethanakul; Vyomesh Patel; David J Mitola; Leif R Lund; Keld Danø; Morten Johnsen; J Silvio Gutkind; Thomas H Bugge
Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma.
Oncogene 2003;22(25):3964-76.
2003: Sarah Netzel-Arnett; John D Hooper; Roman Szabo; Edwin L Madison; James P Quigley; Thomas H Bugge; Toni M Antalis
Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer.
Cancer metastasis reviews 2003;22(2-3):237-58.
2003: Lars H Engelholm; Karin List; Sarah Netzel-Arnett; Edna Cukierman; David J Mitola; Hannah Aaronson; Lars Kjøller; Jørgen K Larsen; Kenneth M Yamada; Dudley K Strickland; Kenn Holmbeck; Keld Danø; Henning Birkedal-Hansen; Niels Behrendt; Thomas H Bugge
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.
The Journal of cell biology 2003;160(7):1009-15.
2003: Shihui Liu; Hannah Aaronson; David J Mitola; Stephen H Leppla; Thomas H Bugge
Potent antitumor activity of a urokinase-activated engineered anthrax toxin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):657-62.
2003: Silvia Montaner; Akrit S Sodhi; Alfredo A Molinolo; Thomas H Bugge; Earl T Sawai; Yunsheng He; Yi Li; Patricio E Ray; J Silvio Gutkind
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes.
Cancer cell 2003;3(1):23-36.
2002: Alejandro Curino; David J Mitola; Hannah Aaronson; Grainne A McMahon; Kamran Raja; Achsah D Keegan; Daniel Lawrence; Thomas H Bugge
Plasminogen promotes sarcoma growth and suppresses the accumulation of tumor-infiltrating macrophages.
Oncogene 2002;21(57):8830-42.
2002: Sarah Netzel-Arnett; David J Mitola; Susan S Yamada; Kali Chrysovergis; Kenn Holmbeck; Henning Birkedal-Hansen; Thomas H Bugge
Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity.
The Journal of biological chemistry 2002;277(47):45154-61.
2002: Manuel Yepes; maria sandkvist; Timothy A Coleman; Elizabeth Moore; Jiang-Young Wu; David J Mitola; Thomas H Bugge; Daniel Lawrence
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.
The Journal of clinical investigation 2002;109(12):1571-8.
2002: Karin List; Christian Haudenschild; Roman Szabo; WanJun Chen; Sharon M Wahl; William D Swaim; Lars H Engelholm; Niels Behrendt; Thomas H Bugge
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis.
Oncogene 2002;21(23):3765-79.
2001: Lars H Engelholm; Boye Nielsen; Sarah Netzel-Arnett; Helene Solberg; X D Chen; J M Lopez Garcia; Carlos Lopez-Otin; M F Young; Henning Birkedal-Hansen; Keld Danø; Leif R Lund; Niels Behrendt; Thomas H Bugge
The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis.
Laboratory investigation; a journal of technical methods and pathology 2001;81(10):1403-14.
2001: S Liu; Thomas H Bugge; Stephen H Leppla
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin.
The Journal of biological chemistry 2001;276(21):17976-84.
2001: Jorge A Bezerra; A R Currier; Hector Melin-Aldana; Gregg E Sabla; Thomas H Bugge; Keith W Kombrinck; Jay L Degen
Plasminogen activators direct reorganization of the liver lobule after acute injury.
The American journal of pathology 2001;158(3):921-9.
2000: Joseph S Palumbo; Keith W Kombrinck; Angela F Drew; T S Grimes; J H Kiser; Jay L Degen; Thomas H Bugge
Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells.
Blood 2000;96(10):3302-9.
2000: Leif R Lund; SF Bjørn; Mark D Sternlicht; Boye Nielsen; Helene Solberg; Pernille Autzen Usher; Ruth Osterby; Ib Jarle Christensen; Ross W Stephens; Thomas H Bugge; Keld Danø; Zena Werb
Lactational competence and involution of the mouse mammary gland require plasminogen.
Development (Cambridge, England) 2000;127(20):4481-92.
2000: Angela F Drew; H L Tucker; Keith W Kombrinck; D I Simon; Thomas H Bugge; Jay L Degen
Plasminogen is a critical determinant of vascular remodeling in mice.
Circulation research 2000;87(2):133-9.
2000: Jon Goguen; Thomas H Bugge; Jay L Degen
Role of the pleiotropic effects of plasminogen deficiency in infection experiments with plasminogen-deficient mice.
Methods (San Diego, Calif.) 2000;21(2):179-83.
2000: Karin List; Ole N Jensen; Thomas H Bugge; Leif R Lund; Michael Ploug; Keld Danø; Niels Behrendt
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.
Biochemistry 2000;39(3):508-15.
2000: Angela F Drew; H L Schiman; Keith W Kombrinck; Thomas H Bugge; Jay L Degen; Adam H Kaufman
Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.
Investigative ophthalmology & visual science 2000;41(1):67-72.
1999: Jorge A Bezerra; Thomas H Bugge; Hector Melin-Aldana; Gregg E Sabla; Keith W Kombrinck; David P Witte; Jay L Degen
Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15143-8.
1999: Zu-Lin Chen; Justin A Indyk; Thomas H Bugge; Keith W Kombrinck; Jay L Degen; Sidney Strickland
Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(22):9813-20.
1999: Leif R Lund; J Romer; Thomas H Bugge; Boye Nielsen; Thomas L Frandsen; J L Degen; Ross W Stephens; Keld Danø
Functional overlap between two classes of matrix-degrading proteases in wound healing.
The EMBO journal 1999;18(17):4645-56.
1998: William Y Sun; David P Witte; Jay L Degen; Melissa C Colbert; MC Burkart; K Holmbäck; Q Xiao; Thomas H Bugge; Sandra J F Degen
Prothrombin deficiency results in embryonic and neonatal lethality in mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7597-602.
1998: Thomas H Bugge; Leif R Lund; K K Kombrinck; Boye Nielsen; K Holmbäck; Angela F Drew; Matthew J Flick; David P Witte; Keld Danø; Jay L Degen
Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.
Oncogene 1998;16(24):3097-104.
1998: Winston W-Y Kao; Candace W-C Kao; Adam H Kaufman; Keith W Kombrinck; Richard L Converse; William V Good; Thomas H Bugge; Jay L Degen
Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.
Investigative ophthalmology & visual science 1998;39(3):502-8.
1998: Angela F Drew; Adam H Kaufman; Keith W Kombrinck; Mary Jo Danton; CC Daugherty; Jay L Degen; Thomas H Bugge
Ligneous conjunctivitis in plasminogen-deficient mice.
Blood 1998;91(5):1616-24.
1997: Thomas H Bugge; Keith W Kombrinck; Q Xiao; K Holmbäck; CC Daugherty; David P Witte; Jay L Degen
Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice.
Blood 1997;90(11):4522-31.
1997: Q Xiao; Mary Jo Danton; David P Witte; Mark C Kowala; Maria T Valentine; Thomas H Bugge; Jay L Degen
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10335-40.
1996: Thomas H Bugge; Keith W Kombrinck; M J Flick; C C Daugherty; Mary Jo Danton; Jay L Degen
Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.
Cell 1996;87(4):709-19.
1996: John Rømer; Thomas H Bugge; C Pyke; Leif R Lund; M J Flick; Jay L Degen; Keld Danø
Plasminogen and wound healing.
Nature medicine 1996;2(7):725.
1996: Thomas H Bugge; Q Xiao; Keith W Kombrinck; M J Flick; K Holmbäck; Mary Jo Danton; Melissa C Colbert; David P Witte; K Fujikawa; E W Davie; Jay L Degen
Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6258-63.
1996: Thomas H Bugge; M J Flick; Mary Jo Danton; C C Daugherty; J Romer; K Dano; P Carmeliet; D Collen; Jay L Degen
Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5899-904.
1996: J Romer; Thomas H Bugge; C Pyke; Leif R Lund; M J Flick; Jay L Degen; K Dano
Impaired wound healing in mice with a disrupted plasminogen gene.
Nature medicine 1996;2(3):287-92.
1995: Thomas H Bugge; T T Suh; M J Flick; C C Daugherty; John Rømer; H Solberg; V Ellis; Keld Danø; Jay L Degen
The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility.
The Journal of biological chemistry 1995;270(28):16886-94.
1995: Thomas H Bugge; M J Flick; C C Daugherty; Jay L Degen
Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.
Genes & development 1995;9(7):794-807.
1993: P Kusk; B O Lindhardt; Thomas H Bugge; K Holmbäck; E F Hulgaard
Mapping of a new immunodominant human linear B-cell epitope on the vpu protein of the human immunodeficiency virus type 1.
Journal of acquired immune deficiency syndromes 1993;6(4):334-8.
1993: K Holmbäck; P Kusk; E F Hulgaard; Thomas H Bugge; E Scheibel; B O Lindhardt
Autologous antibody response against the principal neutralizing domain of human immunodeficiency virus type 1 isolated from infected humans.
Journal of virology 1993;67(3):1612-9.
1992: P Kusk; K Holmbäck; B O Lindhardt; E F Hulgaard; Thomas H Bugge
Mapping of two new human B-cell epitopes on HIV-1 gp120.
AIDS (London, England) 1992;6(12):1451-6.
1992: P Kusk; Thomas H Bugge; B O Lindhardt; E F Hulgaard; K Holmbäck
Mapping of linear B-cell epitopes on the major core protein p24 of human immunodeficiency virus type 1 (HIV-1).
AIDS research and human retroviruses 1992;8(10):1789-94.
1991: Thomas H Bugge; L L Hansen; B O Lindhardt; B Kvinesdal; P Kusk; K Holmbäck; E Hulgaard; K Ulrich
Competition ELISA using a human monoclonal antibody for detection of antibodies against human immunodeficiency virus type 1.
Journal of virological methods 1991;32(1):1-10.
1990: Thomas H Bugge; B O Lindhardt; L L Hansen; P Kusk; E Hulgaard; K Holmbäck; P J Klasse; J Zeuthen; K Ulrich
Analysis of a highly immunodominant epitope in the human immunodeficiency virus type 1 transmembrane glycoprotein, gp41, defined by a human monoclonal antibody.
Journal of virology 1990;64(9):4123-9.
1990: H Andreassen; Henrik Bohr; J Bohr; Søren Brunak; Thomas H Bugge; R M Cotterill; C Jacobsen; P Kusk; B Lautrup; Steffen Petersen
Analysis of the secondary structure of the human immunodeficiency virus (HIV) proteins p17, gp120, and gp41 by computer modeling based on neural network methods.
Journal of acquired immune deficiency syndromes 1990;3(6):615-22.