Luis Blanco

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Andrade Paula; Martín María José; Juárez Raquel; López de Saro Francisco; Blanco Luis
Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ.
Lucas Daniel; Escudero Beatriz; Ligos José Manuel; Segovia Jose Carlos; Estrada Juan Camilo; Terrados Gloria; Blanco Luis; Samper Enrique; Bernad Antonio
Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair.
Terrados Gloria; Capp Jean-Pascal; Canitrot Yvan; García-Díaz Miguel; Bebenek Katarzyna; Kirchhoff Tomas; Villanueva Alberto; Boudsocq François; Bergoglio Valérie; Cazaux Christophe; Kunkel Thomas A; Hoffmann Jean-Sébastien; Blanco Luis
Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ.

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All Publications

2009: Andrade Paula; Martín María José; Juárez Raquel; López de Saro Francisco; Blanco Luis
Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16203-8.
2009: Lucas Daniel; Escudero Beatriz; Ligos José Manuel; Segovia Jose Carlos; Estrada Juan Camilo; Terrados Gloria; Blanco Luis; Samper Enrique; Bernad Antonio
Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair.
PLoS genetics 2009;5(2):e1000389.
2009: Terrados Gloria; Capp Jean-Pascal; Canitrot Yvan; García-Díaz Miguel; Bebenek Katarzyna; Kirchhoff Tomas; Villanueva Alberto; Boudsocq François; Bergoglio Valérie; Cazaux Christophe; Kunkel Thomas A; Hoffmann Jean-Sébastien; Blanco Luis
Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ.
PloS one 2009;4(10):e7290.
2008: Zhou Rui-Zhe; Blanco Luis; Garcia-Diaz Miguel; Bebenek Katarzyna; Kunkel Thomas A; Povirk Lawrence F
Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts.
Nucleic acids research 2008;36(9):2895-905.
2008: Salas Margarita; Blanco Luis; Lázaro José M; de Vega Miguel
The bacteriophage phi29 DNA polymerase.
IUBMB life 2008;60(1):82-5.
2007: Picher Angel J; Blanco Luis
Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine.
DNA repair 2007;6(12):1749-56.
2007: Brissett Nigel C; Pitcher Robert S; Juarez Raquel; Picher Angel J; Green Andrew J; Dafforn Timothy R; Fox Gavin C; Blanco Luis; Doherty Aidan J
Structure of a NHEJ polymerase-mediated DNA synaptic complex.
Science (New York, N.Y.) 2007;318(5849):456-9.
2007: Berman Andrea J; Kamtekar Satwik; Goodman Jessica L; Lázaro José M; de Vega Miguel; Blanco Luis; Salas Margarita; Steitz Thomas A
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases.
The EMBO journal 2007;26(14):3494-505.
2007: Pitcher Robert S; Brissett Nigel C; Picher Angel J; Andrade Paula; Juarez Raquel; Thompson Darren; Fox Gavin C; Blanco Luis; Doherty Aidan J
Structure and function of a mycobacterial NHEJ DNA repair polymerase.
Journal of molecular biology 2007;366(2):391-405.
2006: Kamtekar Satwik; Berman Andrea J; Wang Jimin; Lázaro José M; de Vega Miguel; Blanco Luis; Salas Margarita; Steitz Thomas A
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition.
The EMBO journal 2006;25(6):1335-43.
2006: Alonso Ana; Terrados Gloria; Picher Angel J; Giraldo Rafael; Blanco Luis; Larraga Vicente
An intrinsic 5'-deoxyribose-5-phosphate lyase activity in DNA polymerase beta from Leishmania infantum supports a role in DNA repair.
DNA repair 2006;5(1):89-101.
2006: Juárez Raquel; Ruiz José F; Nick McElhinny Stephanie A; Ramsden Dale; Blanco Luis
A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis.
Nucleic acids research 2006;34(16):4572-82.
2006: Picher Angel J; García-Díaz Miguel; Bebenek Katarzyna; Pedersen Lars C; Kunkel Thomas A; Blanco Luis
Promiscuous mismatch extension by human DNA polymerase lambda.
Nucleic acids research 2006;34(11):3259-66.
2005: Nick McElhinny Stephanie A; Havener Jody M; Garcia-Diaz Miguel; Juárez Raquel; Bebenek Katarzyna; Kee Barbara L; Blanco Luis; Kunkel Thomas A; Ramsden Dale A
A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.
Molecular cell 2005;19(3):357-66.
2005: Lebedeva Natalia A; Rechkunova Nadejda I; Dezhurov Sergey V; Khodyreva Svetlana N; Favre Alain; Blanco Luis; Lavrik Olga I
Comparison of functional properties of mammalian DNA polymerase lambda and DNA polymerase beta in reactions of DNA synthesis related to DNA repair.
Biochimica et biophysica acta 2005;1751(2):150-8.
2005: Rodríguez Irene; Lázaro José M; Blanco Luis; Kamtekar Satwik; Berman Andrea J; Wang Jimin; Steitz Thomas A; Salas Margarita; de Vega Miguel
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6407-12.
2005: Lucas Daniel; Laín de Lera Teresa; González Manuel A; Ruiz Jose F; Domínguez Orlando; Casanova Jesús C; Martínez-A Carlos; Blanco Luis; Bernad Antonio
Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts.
European journal of immunology 2005;35(5):1601-11.
2005: González-Barrera Sergio; Sánchez Arancha; Ruiz José F; Juárez Raquel; Picher Angel J; Terrados Gloria; Andrade Paula; Blanco Luis
Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe.
Nucleic acids research 2005;33(15):4762-74.
2004: Kamtekar Satwik; Berman Andrea J; Wang Jimin; Lázaro José M; de Vega Miguel; Blanco Luis; Salas Margarita; Steitz Thomas A
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29.
Molecular cell 2004;16(4):609-18.
2004: Parlanti Eleonora; Pascucci Barbara; Terrados Gloria; Blanco Luis; Dogliotti Eugenia
Aphidicolin-resistant and -sensitive base excision repair in wild-type and DNA polymerase beta-defective mouse cells.
DNA repair 2004;3(7):703-10.
2004: Garcia-Diaz Miguel; Bebenek Katarzyna; Krahn Joseph M; Blanco Luis; Kunkel Thomas A; Pedersen Lars C
A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology.
Molecular cell 2004;13(4):561-72.
2004: Covo Shay; Blanco Luis; Livneh Zvi
Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity.
The Journal of biological chemistry 2004;279(2):859-65.
2004: Lee Jae Wan; Blanco Luis; Zhou Tong; Garcia-Diaz Miguel; Bebenek Katarzyna; Kunkel Thomas A; Wang Zhigang; Povirk Lawrence F
Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.
The Journal of biological chemistry 2004;279(1):805-11.
2004: Ruiz José F; Lucas Daniel; García-Palomero Esther; Saez Ana I; González Manuel A; Piris Miguel A; Bernad Antonio; Blanco Luis
Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate.
Nucleic acids research 2004;32(19):5861-73.
2003: Bebenek Katarzyna; Garcia-Diaz Miguel; Blanco Luis; Kunkel Thomas A
The frameshift infidelity of human DNA polymerase lambda. Implications for function.
The Journal of biological chemistry 2003;278(36):34685-90.
2003: DeRose Eugene F; Kirby Thomas W; Mueller Geoffrey A; Bebenek Katarzyna; Garcia-Diaz Miguel; Blanco Luis; Kunkel Thomas A; London Robert E
Solution structure of the lyase domain of human DNA polymerase lambda.
Biochemistry 2003;42(32):9564-74.
2003: Ruiz José F; Juárez Raquel; García-Díaz Miguel; Terrados Gloria; Picher Angel J; González-Barrera Sergio; Fernández de Henestrosa Antonio R; Blanco Luis
Lack of sugar discrimination by human Pol mu requires a single glycine residue.
Nucleic acids research 2003;31(15):4441-9.
2003: Truniger Verónica; Lázaro José M; de Vega Miguel; Blanco Luis; Salas Margarita
phi 29 DNA polymerase residue Leu384, highly conserved in motif B of eukaryotic type DNA replicases, is involved in nucleotide insertion fidelity.
The Journal of biological chemistry 2003;278(35):33482-91.
2003: García-Díaz Miguel; Ruiz José F; Juárez Raquel; Terrados Gloria; Blanco Luis
Are there mutator polymerases?
TheScientificWorldJournal 2003;3():422-31.
2003: Ramadan Kristijan; Maga Giovanni; Shevelev Igor V; Villani Giuseppe; Blanco Luis; Hübscher Ulrich
Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions.
Journal of molecular biology 2003;328(1):63-72.
2003: García-Escudero Ramón; García-Díaz Miguel; Salas María L; Blanco Luis; Salas José
DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA.
Journal of molecular biology 2003;326(5):1403-12.
2002: Maga Giovanni; Villani Giuseppe; Ramadan Kristijan; Shevelev Igor; Tanguy Le Gac Nicolas; Blanco Luis; Blanca Giuseppina; Spadari Silvio; Hübscher Ulrich
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.
The Journal of biological chemistry 2002;277(50):48434-40.
2002: Duvauchelle Jean-Baptiste; Blanco Luis; Fuchs Robert P P; Cordonnier Agnes M
Human DNA polymerase mu (Pol mu) exhibits an unusual replication slippage ability at AAF lesion.
Nucleic acids research 2002;30(9):2061-7.
2002: Truniger Verónica; Lázaro José M; Blanco Luis; Salas Margarita
A highly conserved lysine residue in phi29 DNA polymerase is important for correct binding of the templating nucleotide during initiation of phi29 DNA replication.
Journal of molecular biology 2002;318(1):83-96.
2002: Truniger Verónica; Lázaro José M; Esteban Francisco J; Blanco Luis; Salas Margarita
A positively charged residue of phi29 DNA polymerase, highly conserved in DNA polymerases from families A and B, is involved in binding the incoming nucleotide.
Nucleic acids research 2002;30(7):1483-92.
2002: García-Díaz Miguel; Bebenek Katarzyna; Sabariegos Rosario; Domínguez Orlando; Rodríguez Josana; Kirchhoff Tomas; García-Palomero Esther; Picher Angel J; Juárez Raquel; Ruiz Jose F; Kunkel Thomas A; Blanco Luis
DNA polymerase lambda, a novel DNA repair enzyme in human cells.
The Journal of biological chemistry 2002;277(15):13184-91.
2001: Burgers P M; Koonin E V; Bruford E; Blanco L; Burtis K C; Christman M F; Copeland W C; Friedberg E C; Hanaoka F; Hinkle D C; Lawrence C W; Nakanishi M; Ohmori H; Prakash L; Prakash S; Reynaud C A; Sugino A; Todo T; Wang Z; Weill J C; Woodgate R
Eukaryotic DNA polymerases: proposal for a revised nomenclature.
The Journal of biological chemistry 2001;276(47):43487-90.
2001: Taladriz S; Hanke T; Ramiro M J; García-Díaz M; García De Lacoba M; Blanco L; Larraga V
Nuclear DNA polymerase beta from Leishmania infantum. Cloning, molecular analysis and developmental regulation.
Nucleic acids research 2001;29(18):3822-34.
2001: García-Díaz M; Bebenek K; Kunkel T A; Blanco L
Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair.
The Journal of biological chemistry 2001;276(37):34659-63.
2001: Ruiz J F; Domínguez O; Laín de Lera T; Garcia-Díaz M; Bernad A; Blanco L
DNA polymerase mu, a candidate hypermutase?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1405):99-109.
2000: Dufour E; Méndez J; Lázaro J M; de Vega M; Blanco L; Salas M
An aspartic acid residue in TPR-1, a specific region of protein-priming DNA polymerases, is required for the functional interaction with primer terminal protein.
Journal of molecular biology 2000;304(3):289-300.
2000: García-Díaz M; Domínguez O; López-Fernández L A; de Lera L T; Saníger M L; Ruiz J F; Párraga M; García-Ortiz M J; Kirchhoff T; del Mazo J; Bernad A; Blanco L
DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis.
Journal of molecular biology 2000;301(4):851-67.
2000: Domínguez O; Ruiz J F; Laín de Lera T; García-Díaz M; González M A; Kirchhoff T; Martínez-A C; Bernad A; Blanco L
DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.
The EMBO journal 2000;19(7):1731-42.
2000: Truniger V; Blanco L; Salas M
Analysis of O29 DNA polymerase by partial proteolysis: binding of terminal protein in the double-stranded DNA channel.
Journal of molecular biology 2000;295(3):441-53.
1999: de Vega M; Blanco L; Salas M
Processive proofreading and the spatial relationship between polymerase and exonuclease active sites of bacteriophage phi29 DNA polymerase.
Journal of molecular biology 1999;292(1):39-51.
1999: Bonnin A; Lázaro J M; Blanco L; Salas M
A single tyrosine prevents insertion of ribonucleotides in the eukaryotic-type phi29 DNA polymerase.
Journal of molecular biology 1999;290(1):241-51.
1999: Illana B; Lázaro J M; Gutiérrez C; Meijer W J; Blanco L; Salas M
Phage phi29 terminal protein residues Asn80 and Tyr82 are recognition elements of the replication origins.
The Journal of biological chemistry 1999;274(21):15073-9.
1999: Truniger V; Blanco L; Salas M
Role of the "YxGG/A" motif of Phi29 DNA polymerase in protein-primed replication.
Journal of molecular biology 1999;286(1):57-69.
1998: de Vega M; Blanco L; Salas M
phi29 DNA polymerase residue Ser122, a single-stranded DNA ligand for 3'-5' exonucleolysis, is required to interact with the terminal protein.
The Journal of biological chemistry 1998;273(44):28966-77.
1998: Saturno J; Lázaro J M; Blanco L; Salas M
Role of the first aspartate residue of the "YxDTDS" motif of phi29 DNA polymerase as a metal ligand during both TP-primed and DNA-primed DNA synthesis.
Journal of molecular biology 1998;283(3):633-42.
1998: Murthy V; Meijer W J; Blanco L; Salas M
DNA polymerase template switching at specific sites on the phi29 genome causes the in vivo accumulation of subgenomic phi29 DNA molecules.
Molecular microbiology 1998;29(3):787-98.
1998: Illana B; Zaballos A; Blanco L; Salas M
The RGD sequence in phage phi29 terminal protein is required for interaction with phi29 DNA polymerase.
Virology 1998;248(1):12-9.
1998: de Vega M; Lázaro J M; Salas M; Blanco L
Mutational analysis of phi29 DNA polymerase residues acting as ssDNA ligands for 3'-5' exonucleolysis.
Journal of molecular biology 1998;279(4):807-22.
1998: Truniger V; Lázaro J M; Salas M; Blanco L
Phi 29 DNA polymerase requires the N-terminal domain to bind terminal protein and DNA primer substrates.
Journal of molecular biology 1998;278(4):741-55.
1997: Oliveros M; Yáñez R J; Salas M L; Salas J; Viñuela E; Blanco L
Characterization of an African swine fever virus 20-kDa DNA polymerase involved in DNA repair.
The Journal of biological chemistry 1997;272(49):30899-910.
1997: de Vega M; Ilyina T; Lázaro J M; Salas M; Blanco L
An invariant lysine residue is involved in catalysis at the 3'-5' exonuclease active site of eukaryotic-type DNA polymerases.
Journal of molecular biology 1997;270(1):65-78.
1997: Saturno J; Lázaro J M; Esteban F J; Blanco L; Salas M
ø29 DNA polymerase residue Lys383, invariant at motif B of DNA-dependent polymerases, is involved in dNTP binding.
Journal of molecular biology 1997;269(3):313-25.
1997: Mendez J; Blanco L; Salas M
Protein-primed DNA replication: a transition between two modes of priming by a unique DNA polymerase.
The EMBO journal 1997;16(9):2519-27.
1997: King A J; Teertstra W R; Blanco L; Salas M; van der Vliet P C
Processive proofreading by the adenovirus DNA polymerase. Association with the priming protein reduces exonucleolytic degradation.
Nucleic acids research 1997;25(9):1745-52.
1997: Esteban J A; Blanco L; Villar L; Salas M
In vitro evolution of terminal protein-containing genomes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2921-6.
1996: Illana B; Blanco L; Salas M
Functional characterization of the genes coding for the terminal protein and DNA polymerase from bacteriophage GA-1. Evidence for a sliding-back mechanism during protein-primed GA-1 DNA replication.
Journal of molecular biology 1996;264(3):453-64.
1996: Martín A C; Blanco L; García P; Salas M; Méndez J
In vitro protein-primed initiation of pneumococcal phage Cp-1 DNA replication occurs at the third 3' nucleotide of the linear template: a stepwise sliding-back mechanism.
Journal of molecular biology 1996;260(3):369-77.
1996: Truniger V; Lázaro J M; Salas M; Blanco L
A DNA binding motif coordinating synthesis and degradation in proofreading DNA polymerases.
The EMBO journal 1996;15(13):3430-41.
1996: Blanco L; Salas M
Relating structure to function in phi29 DNA polymerase.
The Journal of biological chemistry 1996;271(15):8509-12.
1996: de Vega M; Lazaro J M; Salas M; Blanco L
Primer-terminus stabilization at the 3'-5' exonuclease active site of phi29 DNA polymerase. Involvement of two amino acid residues highly conserved in proofreading DNA polymerases.
The EMBO journal 1996;15(5):1182-92.
1995: Saturno J; Blanco L; Salas M; Esteban J A
A novel kinetic analysis to calculate nucleotide affinity of proofreading DNA polymerases. Application to phi 29 DNA polymerase fidelity mutants.
The Journal of biological chemistry 1995;270(52):31235-43.
1995: Salas M; Freire R; Soengas M S; Esteban J A; Méndez J; Bravo A; Serrano M; Blasco M A; Lázaro J M; Blanco L
Protein-nucleic acid interactions in bacteriophage phi 29 DNA replication.
FEMS microbiology reviews 1995;17(1-2):73-82.
1995: Blasco M A; Méndez J; Lázaro J M; Blanco L; Salas M
Primer terminus stabilization at the phi 29 DNA polymerase active site. Mutational analysis of conserved motif KXY.
The Journal of biological chemistry 1995;270(6):2735-40.
1995: Lázaro J M; Blanco L; Salas M
Purification of bacteriophage phi 29 DNA polymerase.
Methods in enzymology 1995;262():42-9.
1995: Blanco L; Salas M
Mutational analysis of bacteriophage phi 29 DNA polymerase.
Methods in enzymology 1995;262():283-94.
1994: Blanco L; Lázaro J M; de Vega M; Bonnin A; Salas M
Terminal protein-primed DNA amplification.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12198-202.
1994: Esteban J A; Soengas M S; Salas M; Blanco L
3'-->5' exonuclease active site of phi 29 DNA polymerase. Evidence favoring a metal ion-assisted reaction mechanism.
The Journal of biological chemistry 1994;269(50):31946-54.
1994: Méndez J; Blanco L; Lázaro J M; Salas M
Primer-terminus stabilization at the psi 29 DNA polymerase active site. Mutational analysis of conserved motif TX2GR.
The Journal of biological chemistry 1994;269(47):30030-8.
1994: Alconada A; Flores A I; Blanco L; Cuezva J M
Antibodies against F1-ATPase alpha-subunit recognize mitochondrial chaperones. Evidence for an evolutionary relationship between chaperonin and ATPase protein families.
The Journal of biological chemistry 1994;269(18):13670-9.
1993: Blasco M A; Lázaro J M; Blanco L; Salas M
Phi 29 DNA polymerase active site. Residue ASP249 of conserved amino acid motif "Dx2SLYP" is critical for synthetic activities.
The Journal of biological chemistry 1993;268(32):24106-13.
1993: Caldentey J; Blanco L; Bamford D H; Salas M
In vitro replication of bacteriophage PRD1 DNA. Characterization of the protein-primed initiation site.
Nucleic acids research 1993;21(16):3725-30.
1993: Blasco M A; Lázaro J M; Blanco L; Salas M
Phi 29 DNA polymerase active site. The conserved amino acid motif "Kx3NSxYG" is involved in template-primer binding and dNTP selection.
The Journal of biological chemistry 1993;268(22):16763-70.
1993: Esteban J A; Salas M; Blanco L
Fidelity of phi 29 DNA polymerase. Comparison between protein-primed initiation and DNA polymerization.
The Journal of biological chemistry 1993;268(4):2719-26.
1992: Soengas M S; Esteban J A; Lázaro J M; Bernad A; Blasco M A; Salas M; Blanco L
Site-directed mutagenesis at the Exo III motif of phi 29 DNA polymerase; overlapping structural domains for the 3'-5' exonuclease and strand-displacement activities.
The EMBO journal 1992;11(11):4227-37.
1992: Méndez J; Blanco L; Esteban J A; Bernad A; Salas M
Initiation of phi 29 DNA replication occurs at the second 3' nucleotide of the linear template: a sliding-back mechanism for protein-primed DNA replication.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9579-83.
1992: Blasco M A; Lázaro J M; Bernad A; Blanco L; Salas M
Phi 29 DNA polymerase active site. Mutants in conserved residues Tyr254 and Tyr390 are affected in dNTP binding.
The Journal of biological chemistry 1992;267(27):19427-34.
1992: Esteban J A; Salas M; Blanco L
Activation of S1 nuclease at neutral pH.
Nucleic acids research 1992;20(18):4932.
1992: Caldentey J; Blanco L; Savilahti H; Bamford D H; Salas M
In vitro replication of bacteriophage PRD1 DNA. Metal activation of protein-primed initiation and DNA elongation.
Nucleic acids research 1992;20(15):3971-6.
1992: Blanco L; Bernad A; Salas M
Evidence favouring the hypothesis of a conserved 3'-5' exonuclease active site in DNA-dependent DNA polymerases.
Gene 1992;112(1):139-44.
1992: Garmendia C; Bernad A; Esteban J A; Blanco L; Salas M
The bacteriophage phi 29 DNA polymerase, a proofreading enzyme.
The Journal of biological chemistry 1992;267(4):2594-9.
1992: Blanco L; Bernad A; Esteban J A; Salas M
DNA-independent deoxynucleotidylation of the phi 29 terminal protein by the phi 29 DNA polymerase.
The Journal of biological chemistry 1992;267(2):1225-30.
1992: Esteban J A; Bernad A; Salas M; Blanco L
Metal activation of synthetic and degradative activities of phi 29 DNA polymerase, a model enzyme for protein-primed DNA replication.
Biochemistry 1992;31(2):350-9.
1992: Blasco M A; Esteban J A; Méndez J; Blanco L; Salas M
Structural and functional studies on phi 29 DNA polymerase.
Chromosoma 1992;102(1 Suppl):S32-8.
1991: Blanco L; Bernad A; Blasco M A; Salas M
A general structure for DNA-dependent DNA polymerases.
Gene 1991;100():27-38.
1991: Blasco M A; Bernad A; Blanco L; Salas M
Characterization and mapping of the pyrophosphorolytic activity of the phage phi 29 DNA polymerase. Involvement of amino acid motifs highly conserved in alpha-like DNA polymerases.
The Journal of biological chemistry 1991;266(12):7904-9.
1991: Blanco L; Bernad A; Salas M
MIP1 DNA polymerase of S. cerevisiae: structural similarity with the E. coli DNA polymerase I-type enzymes.
Nucleic acids research 1991;19(4):955.
1990: Bernad A; Blanco L; Salas M
Site-directed mutagenesis of the YCDTDS amino acid motif of the phi 29 DNA polymerase.
Gene 1990;94(1):45-51.
1990: Blasco M A; Blanco L; Parés E; Salas M; Bernad A
Structural and functional analysis of temperature-sensitive mutants of the phage phi 29 DNA polymerase.
Nucleic acids research 1990;18(16):4763-70.
1990: Bernad A; Lázaro J M; Salas M; Blanco L
The highly conserved amino acid sequence motif Tyr-Gly-Asp-Thr-Asp-Ser in alpha-like DNA polymerases is required by phage phi 29 DNA polymerase for protein-primed initiation and polymerization.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4610-4.
1989: Bernad A; Blanco L; Lázaro J M; Martín G; Salas M
A conserved 3'----5' exonuclease active site in prokaryotic and eukaryotic DNA polymerases.
Cell 1989;59(1):219-28.
1989: Blanco L; Bernad A; Lázaro J M; Martín G; Garmendia C; Salas M
Highly efficient DNA synthesis by the phage phi 29 DNA polymerase. Symmetrical mode of DNA replication.
The Journal of biological chemistry 1989;264(15):8935-40.
1988: Blanco L; Bernad A; Salas M
Transition from initiation to elongation in protein-primed phi 29 DNA replication: salt-dependent stimulation by the viral protein p6.
Journal of virology 1988;62(11):4167-72.
1987: Blanco L; Prieto I; Gutiérrez J; Bernad A; Lázaro J M; Hermoso J M; Salas M
Effect of NH4+ ions on phi 29 DNA-protein p3 replication: formation of a complex between the terminal protein and the DNA polymerase.
Journal of virology 1987;61(12):3983-91.
1987: Bernad A; Zaballos A; Salas M; Blanco L
Structural and functional relationships between prokaryotic and eukaryotic DNA polymerases.
The EMBO journal 1987;6(13):4219-25.
1986: Blanco L; Salas M
Effect of aphidicolin and nucleotide analogs on the phage phi 29 DNA polymerase.
Virology 1986;153(2):179-87.
1986: Blanco L; Gutiérrez J; Lázaro J M; Bernad A; Salas M
Replication of phage phi 29 DNA in vitro: role of the viral protein p6 in initiation and elongation.
Nucleic acids research 1986;14(12):4923-37.
1986: Gutiérrez J; García J A; Blanco L; Salas M
Cloning and template activity of the origins of replication of phage phi 29 DNA.
Gene 1986;43(1-2):1-11.
1985: Pastrana R; Lázaro J M; Blanco L; García J A; Méndez E; Salas M
Overproduction and purification of protein P6 of Bacillus subtilis phage phi 29: role in the initiation of DNA replication.
Nucleic acids research 1985;13(9):3083-100.
1985: Blanco L; Salas M
Characterization of a 3'----5' exonuclease activity in the phage phi 29-encoded DNA polymerase.
Nucleic acids research 1985;13(4):1239-49.
1984: Blanco L; Salas M
Characterization and purification of a phage phi 29-encoded DNA polymerase required for the initiation of replication.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(17):5325-9.
1984: Blanco L; García J A; Salas M
Cloning and expression of gene 2, required for the protein-primed initiation of the Bacillus subtilis phage phi 29 DNA replication.
Gene 1984;29(1-2):33-40.
1984: García J A; Peñalva M A; Blanco L; Salas M
Template requirements for initiation of phage phi 29 DNA replication in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(1):80-4.
1984: Salas M; Blanco L; Prieto I; García J A; Mellado R P; Lázaro J M; Hermoso J M
In vitro replication of bacteriophage phi 29.
Advances in experimental medicine and biology 1984;179():35-44.
1984: Blanco L; García J A; Lázaro J M; Salas M
Overproduction and purification of the gene 2 product involved in the initiation of phage phi 29 replication.
Advances in experimental medicine and biology 1984;179():193-7.
1983: Blanco L; Garcìa J A; Peñalva M A; Salas M
Factors involved in the initiation of phage phi 29 DNA replication in vitro: requirement of the gene 2 product for the formation of the protein p3-dAMP complex.
Nucleic acids research 1983;11(5):1309-23.

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