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Kevin Pavelko

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Kevin Pavelko; Kathleen S Allen; Michael P Bell; Michael J Hansen; Lavakumar Karyampudi; Keith L Knutson; Larry R Pease
The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine.
Kevin Pavelko; Moses Rodriguez; Michael P Bell; Chella S David; Michael J Hansen; Aaron J Johnson; Yanice V Mendez-Fernandez; Larry R Pease
Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.
Istvan Pirko; Kathleen S Allen; Yi Chen; R Scott Dunn; Jeff Gamez; Diana M Lindquist; Anne K Lohrey; Slobodan Macura; Jeremiah McDole; Kevin Pavelko; Aaron J Johnson
Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation.

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All Publications

2013: Kevin Pavelko; Kathleen S Allen; Michael P Bell; Michael J Hansen; Lavakumar Karyampudi; Keith L Knutson; Larry R Pease
The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(5):1087-95.
2012: Kevin Pavelko; Moses Rodriguez; Michael P Bell; Chella S David; Michael J Hansen; Aaron J Johnson; Yanice V Mendez-Fernandez; Larry R Pease
Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.
PLoS pathogens 2012;8(2):e1002541.
2012: Istvan Pirko; Kathleen S Allen; Yi Chen; R Scott Dunn; Jeff Gamez; Diana M Lindquist; Anne K Lohrey; Slobodan Macura; Jeremiah McDole; Kevin Pavelko; Aaron J Johnson
Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation.
PloS one 2012;7(2):e31459.
2011: Kevin Pavelko; Megan A Girtman; Yoshihiro Mitsunaga; Yanice V Mendez-Fernandez; Michael P Bell; Michael J Hansen; Kathleen S Allen; Moses Rodriguez; Larry R Pease
Theiler's murine encephalomyelitis virus as a vaccine candidate for immunotherapy.
PloS one 2011;6(5):e20217.
2009: Kevin Pavelko; Michael J Hansen; Larry R Pease
CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection.
Cancer research 2009;69(7):3114-20.
2008: Kevin Pavelko; Karin L Heckman; Michael J Hansen; Larry R Pease
An effective vaccine strategy protective against antigenically distinct tumor variants.
Cancer research 2008;68(7):2471-8.
2008: Moses Rodriguez; Laurie J Zoecklein; Jason G Kerkvliet; Kevin Pavelko; Louisa M Papke; Charles Howe; Larry R Pease; Chella S David
Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination.
Journal of virology 2008;82(7):3369-80.
2007: Karin L Heckman; Erin L Schenk; Suresh Radhakrishnan; Kevin Pavelko; Michael J Hansen; Larry R Pease
Fast-tracked CTL: rapid induction of potent anti-tumor killer T cells in situ.
European journal of immunology 2007;37(7):1827-35.
2007: Kevin Pavelko; Larry R Pease; Chella S David; Moses Rodriguez
Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination.
Brain pathology (Zurich, Switzerland) 2007;17(2):184-96.
2006: Moses Rodriguez; Laurie J Zoecklein; Jeff Gamez; Kevin Pavelko; Louisa M Papke; Shunya Nakane; Charles Howe; Suresh Radhakrishnan; Michael J Hansen; Chella S David; Arthur E Warrington; Larry R Pease
STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):343-5.
2003: Moses Rodriguez; Laurie J Zoecklein; Charles Howe; Kevin Pavelko; Jeff Gamez; Shunya Nakane; Louisa M Papke
Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection.
Journal of virology 2003;77(22):12252-65.
2003: Shunya Nakane; Laurie J Zoecklein; Jeff Gamez; Louisa M Papke; Kevin Pavelko; Jean-François Bureau; Michel Brahic; Larry R Pease; Moses Rodriguez
A 40-cM region on chromosome 14 plays a critical role in the development of virus persistence, demyelination, brain pathology and neurologic deficits in a murine viral model of multiple sclerosis.
Brain pathology (Zurich, Switzerland) 2003;13(4):519-33.
2003: Laurie J Zoecklein; Kevin Pavelko; Jeff Gamez; Louisa M Papke; Dorian B McGavern; Daren R Ure; M Kariuki Njenga; Aaron J Johnson; Shunya Nakane; Moses Rodriguez
Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus.
Brain pathology (Zurich, Switzerland) 2003;13(3):291-308.
2003: Kevin Pavelko; Charles Howe; Kristen Drescher; Jeff Gamez; Aaron J Johnson; Tao Wei; Richard M Ransohoff; Moses Rodriguez
Interleukin-6 protects anterior horn neurons from lethal virus-induced injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(2):481-92.
2002: Xiaoqi Lin; M Kariuki Njenga; Aaron J Johnson; Kevin Pavelko; Chella S David; Larry R Pease; Moses Rodriguez
Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelination.
Journal of virology 2002;76(15):7799-811.
2002: Richard M Ransohoff; Tao Wei; Kevin Pavelko; J-C Lee; Paul D Murray; Moses Rodriguez
Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: roles of CD4+ and CD8+ T cells and viral persistence.
Journal of virology 2002;76(5):2217-24.
2001: Aaron J Johnson; J Upshaw; Kevin Pavelko; M Rodriguez; Larry R Pease
Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2760-2.
2000: Moses Rodriguez; Raymond P Roos; Dorian B McGavern; Laurie J Zoecklein; Kevin Pavelko; H Sang; Xiaoqi Lin
The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations.
Virology 2000;275(1):9-19.
2000: Kevin Pavelko; Kristen Drescher; Dorian B McGavern; Chella S David; Moses Rodriguez
HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis.
Molecular and cellular neurosciences 2000;15(6):495-509.
2000: Kristen Drescher; Laurie J Zoecklein; Kevin Pavelko; C Rivera-Quinones; D Hollenbaugh; Moses Rodriguez
CD40L is critical for protection from demyelinating disease and development of spontaneous remyelination in a mouse model of multiple sclerosis.
Brain pathology (Zurich, Switzerland) 2000;10(1):1-15.
1998: Paul D Murray; Kevin Pavelko; J Leibowitz; Xiaoqi Lin; Moses Rodriguez
CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.
Journal of virology 1998;72(9):7320-9.
1998: Kevin Pavelko; B G van Engelen; Moses Rodriguez
Acceleration in the rate of CNS remyelination in lysolecithin-induced demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(7):2498-505.
1997: Claudia F Lucchinetti; D W Kimmel; Kevin Pavelko; Moses Rodriguez
5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus.
Experimental neurology 1997;147(1):123-9.
1997: B G van Engelen; Kevin Pavelko; Moses Rodriguez
Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination.
Multiple sclerosis (Houndmills, Basingstoke, England) 1997;3(2):76-9.
1996: Moses Rodriguez; Kevin Pavelko; M Kariuki Njenga; W C Logan; Peter J Wettstein
The balance between persistent virus infection and immune cells determines demyelination.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5699-709.
1996: M Kariuki Njenga; Kevin Pavelko; J Baisch; Xiaoqi Lin; Chella S David; J Leibowitz; Moses Rodriguez
Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice.
Journal of virology 1996;70(3):1729-37.
1995: Moses Rodriguez; Kevin Pavelko; R L Coffman
Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.
Journal of virology 1995;69(11):7286-90.
1994: B G M van Engelen; David Miller; Kevin Pavelko; Otto R Hommes; Moses Rodriguez
Promotion of remyelination by polyclonal immunoglobulin in Theiler's virus-induced demyelination and in multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 1994;57 Suppl():65-8.
1994: Moses Rodriguez; Kevin Pavelko; C W McKinney; J L Leibowitz
Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3811-21.