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Ronald J. Lukas

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Lifang Yu; Han-Kun Zhang; Ronald J. Lukas; Dani Brunner; J Brek Eaton; Allison Fedolak; Taleen Hanania; Alan P Kozikowski
Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
Han-Kun Zhang; Vadim Alexandrov; Daniela Brunner; J Brek Eaton; Allison Fedolak; Taleen Hanania; Ronald J. Lukas; Angelica Mazzolari; Mieke Nys; Emily Sabath; August B Smit; Chris Ulens; René Van Elk; Giulio Vistoli; Lifang Yu; Alan P Kozikowski
Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.
Die Zhang; Dan Xu; Ming Gao; Boris S Gutkin; Ronald J. Lukas; Wei-Xing Shi; Scott C Steffensen; Jie Wu
Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized rats.

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2012: Lifang Yu; Han-Kun Zhang; Ronald J. Lukas; Dani Brunner; J Brek Eaton; Allison Fedolak; Taleen Hanania; Alan P Kozikowski
Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
Journal of medicinal chemistry 2012;55(22):9998-10009.
2012: Han-Kun Zhang; Vadim Alexandrov; Daniela Brunner; J Brek Eaton; Allison Fedolak; Taleen Hanania; Ronald J. Lukas; Angelica Mazzolari; Mieke Nys; Emily Sabath; August B Smit; Chris Ulens; René Van Elk; Giulio Vistoli; Lifang Yu; Alan P Kozikowski
Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.
Journal of medicinal chemistry 2012;55(18):8028-37.
2012: Die Zhang; Dan Xu; Ming Gao; Boris S Gutkin; Ronald J. Lukas; Wei-Xing Shi; Scott C Steffensen; Jie Wu
Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(36):12366-75.
2012: Hankun Zhang; Krishna Mohan Bajjuri; Daniela Brunner; Barbara Caldarone; J Brek Eaton; Allison Fedolak; Afshin Ghavami; David A Lowe; Ronald J. Lukas; Neil E Paterson; Werner Tückmantel; Daguang Wang; Lifang Yu; Po-wai Yuen; Alan P Kozikowski
Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.
Journal of medicinal chemistry 2012;55(2):717-24.
2012: Lifang Yu; Ronald J. Lukas; Werner Tückmantel; Dani Brunner; Barbara Caldarone; J Brek Eaton; Allison Fedolak; Taleen Hanania; Alan P Kozikowski
Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
Journal of medicinal chemistry 2012;55(2):812-23.
2011: Jianhua Liu; David A Lowe; Ronald J. Lukas; Christina Ruiz; Matthew Terry; Daguang Wang; Lifang Yu; Dani Brunner; Barbara Caldarone; Katie Cavino; J Brek Eaton; Allison Fedolak; Afshin Ghavami; Alan P Kozikowski
Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.
Journal of medicinal chemistry 2011;54(20):7280-8.
2011: Jie Wu; Ronald J. Lukas
Naturally-expressed nicotinic acetylcholine receptor subtypes.
Biochemical pharmacology 2011;82(8):800-7.
2011: Jianliang Zhang; Yao Huang; Chaokun Li; Ronald J. Lukas; Benchang Shen; Paul Whiteaker; Wen Wu; Fenqin Xue; Yongchang Chang
Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness.
The Journal of biological chemistry 2011;286(28):25331-40.
2011: F Ivy Carroll; Ana Z Muresan; Bruce E Blough; Hernán A Navarro; Wayne Mascarella; J Brek Eaton; Xiaodong Huang; M Imad Damaj; Ronald J. Lukas
Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.
Journal of medicinal chemistry 2011;54(5):1441-8.
2011: Kechun Yang; Lori Buhlman; Ghous M Khan; Robert A Nichols; Guozhang Jin; J Michael McIntosh; Paul Whiteaker; Ronald J. Lukas; Jie Wu
Functional nicotinic acetylcholine receptors containing α6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(7):2537-48.
2011: Junwei Hao; Alain R Simard; Gregory H Turner; Jie Wu; Paul Whiteaker; Ronald J. Lukas; Fu-Dong Shi
Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors.
Experimental neurology 2011;227(1):110-9.
2010: Nicholas C Bambakidis; Xukui Wang; Ronald J. Lukas; Robert F Spetzler; Volker K H Sonntag; Mark C Preul
Intravenous hedgehog agonist induces proliferation of neural and oligodendrocyte precursors in rodent spinal cord injury.
Neurosurgery 2010;67(6):1709-15; discussion 1715.
2010: Chao Zheng; Kechun Yang; Qiang Liu; Meng-Ya Wang; Jianxin Shen; A Sofía Vallés; Ronald J. Lukas; Francisco J Barrantes; Jie Wu
The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 2010;335(2):401-8.
2010: Jianhua Liu; J Brek Eaton; Barbara Caldarone; Ronald J. Lukas; Alan P Kozikowski
Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists.
Journal of medicinal chemistry 2010;53(19):6973-85.
2010: Hui Zhen Nie; Sha Shi; Ronald J. Lukas; Wen Juan Zhao; Yong Ning Sun; Ming Yin
Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells.
Brain research 2010;1356():112-20.
2010: Ming Gao; Yu Jin; Kechun Yang; Die Zhang; Ronald J. Lukas; Jie Wu
Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(41):13814-25.
2010: M Imad Damaj; Sheri D Grabus; Hernán A Navarro; Robert Vann; Jonathan A Warner; Lindsey S King; Jenny L Wiley; Bruce E Blough; Ronald J. Lukas; F Ivy Carroll
Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice.
The Journal of pharmacology and experimental therapeutics 2010;334(3):1087-95.
2010: Ronald J. Lukas; Ana Z Muresan; M Imad Damaj; Bruce E Blough; Xiaodong Huang; Hernán A Navarro; S Wayne Mascarella; J Brek Eaton; Syndia K Marxer-Miller; F Ivy Carroll
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.
Journal of medicinal chemistry 2010;53(12):4731-48.
2010: F Ivy Carroll; Bruce E Blough; Wayne Mascarella; Hernán A Navarro; J Brek Eaton; Ronald J. Lukas; M Imad Damaj
Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.
Journal of medicinal chemistry 2010;53(5):2204-14.
2010: B Blair Braden; Joshua S Talboom; Ian D Crain; Alain R Simard; Ronald J. Lukas; Laszlo Prokai; Melissa R Scheldrup; Bronson L Bowman; Heather A Bimonte-Nelson
Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats.
Neurobiology of learning and memory 2010;93(3):444-53.
2009: Alan P Kozikowski; J Brek Eaton; Krishna Mohan Bajjuri; Sheela K Chellappan; Yihua Chen; Sudhakar Karadi; Rong He; Barbara Caldarone; Michael Manzano; Po-wai Yuen; Ronald J. Lukas
Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression.
ChemMedChem 2009;4(8):1279-91.
2009: Teresa Murray; Qiang Liu; Paul Whiteaker; Jie Wu; Ronald J. Lukas
Nicotinic acetylcholine receptor alpha7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors.
Acta pharmacologica Sinica 2009;30(6):828-41.
2009: Kewei D Yu; Qiang Liu; Jie Wu; Ronald J. Lukas
Kinetics of desensitization and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cells.
Acta pharmacologica Sinica 2009;30(6):805-17.
2009: Wen-Hua Piao; Denise Campagnolo; Carlos Dayao; Ronald J. Lukas; Jie Wu; Fu-Dong Shi
Nicotine and inflammatory neurological disorders.
Acta pharmacologica Sinica 2009;30(6):715-22.
2009: Chao Zheng; Meng-Ya Wang; Qiang Liu; Makoto Wakui; Paul Whiteaker; Ronald J. Lukas; Jie Wu
U18666A, a cholesterol-inhibition agent, modulates human neuronal nicotinic acetylcholine receptors heterologously expressed in SH-EP1 cell line.
Journal of neurochemistry 2009;108(6):1526-38.
2009: Fu-Dong Shi; Wen-Hua Piao; Yen-Ping Kuo; Denise I Campagnolo; Timothy L Vollmer; Ronald J. Lukas
Nicotinic attenuation of central nervous system inflammation and autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1730-9.
2009: Qiang Liu; Yao Huang; Fenqin Xue; Alain Simard; Jamie DeChon; Guohui Li; Jianliang Zhang; Linda Lucero; Min Wang; Michael R Sierks; Gang Hu; Yongchang Chang; Ronald J. Lukas; Jie Wu
A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(4):918-29.
2009: Kechun Yang; Jun Hu; Linda Lucero; Qiang Liu; Chao Zheng; Xuechu Zhen; Guozhang Jin; Ronald J. Lukas; Jie Wu
Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons.
The Journal of physiology 2009;587(Pt 2):345-61.
2008: Qiang Liu; Ke-wei Yu; Yong-chang Chang; Ronald J. Lukas; Jie Wu
Agonist-induced hump current production in heterologously-expressed human alpha4beta2-nicotinic acetylcholine receptors.
Acta pharmacologica Sinica 2008;29(3):305-19.
2008: Huizhen Nie; Zuoqing Li; Ronald J. Lukas; Yinghua Shen; Li Song; Xin Wang; Ming Yin
Construction of SH-EP1-alpha4beta2-hAPP695 cell line and effects of nicotinic agonists on beta-amyloid in the cells.
Cellular and molecular neurobiology 2008;28(1):103-12.
2008: Jean-François Etter; Ronald J. Lukas; Neal L Benowitz; Robert West; Carolyn M Dresler
Cytisine for smoking cessation: a research agenda.
Drug and alcohol dependence 2008;92(1-3):3-8.
2007: Ginny G Farías; Ana S Vallés; Marcela Colombres; Juan A Godoy; Enrique M Toledo; Ronald J. Lukas; Francisco Barrantes; Nibaldo C Inestrosa
Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(20):5313-25.
2007: Shannon G Matta; David J K Balfour; Neal L Benowitz; R Thomas Boyd; Jerry J Buccafusco; Anthony R Caggiula; Caroline R Craig; Allan C Collins; M Imad Damaj; Eric C Donny; Phillip S Gardiner; Sharon R Grady; Ulrike Heberlein; Sherry S Leonard; Edward Levin; Ronald J. Lukas; Athina Markou; Michael J Marks; Sarah E McCallum; Neeraja Parameswaran; Kenneth A Perkins; Marina R Picciotto; Maryka Quik; Jed E Rose; Adrian Rothenfluh; William R Schafer; Ian P Stolerman; Rachel F Tyndale; Jeanne M Wehner; Jeffrey M Zirger
Guidelines on nicotine dose selection for in vivo research.
Psychopharmacology 2007;190(3):269-319.
2006: Travis Dunkley; Ronald J. Lukas
Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells.
Brain research 2006;1116(1):39-49.
2006: Jie Wu; Qiang Liu; Kewei Yu; Jun Hu; Yen-Ping Kuo; Marsha Segerberg; Paul S. St. John; Ronald J. Lukas
Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors.
The Journal of physiology 2006;576(Pt 1):103-18.
2006: Richard Exley; Mirko Moroni; Federica Sasdelli; Lee M Houlihan; Ronald J. Lukas; Emanuele Sher; Ruud Zwart; Isabel Bermudez
Chaperone protein 14-3-3 and protein kinase A increase the relative abundance of low agonist sensitivity human alpha 4 beta 2 nicotinic acetylcholine receptors in Xenopus oocytes.
Journal of neurochemistry 2006;98(3):876-85.
2006: Jun Hu; Kari Lindenberger; Gang Hu; Hai Wang; Ronald J. Lukas; Jie Wu
Iptakalim as a human nicotinic acetylcholine receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2006;316(2):914-25.
2005: Jukka S Pakkanen; Heli Nousiainen; Jari Yli-Kauhaluoma; Irene Kylänlahti; Tommi Möykkynen; Esa R Korpi; Jian-Hong Peng; Ronald J. Lukas; Liisa Ahtee; Raimo K Tuominen
Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors.
Journal of neurochemistry 2005;94(5):1329-41.
2005: Richard Exley; Patricio Iturriaga-Vásquez; Ronald J. Lukas; Emanuele Sher; Bruce K Cassels; Isabel Bermudez
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors.
British journal of pharmacology 2005;146(1):15-24.
2005: Yen-Ping Kuo; Lin Xu; J Brek Eaton; Lingke Zhao; Jie Wu; Ronald J. Lukas
Roles for nicotinic acetylcholine receptor subunit large cytoplasmic loop sequences in receptor expression and function.
The Journal of pharmacology and experimental therapeutics 2005;314(1):455-66.
2005: Chuanzhe Song; Teresa Murray; Ryoichi Kimura; Makoto Wakui; Kevin Ellsworth; Sam P Javedan; Syndia Marxer-Miller; Ronald J. Lukas; Jie Wu
Role of alpha7-nicotinic acetylcholine receptors in tetanic stimulation-induced gamma oscillations in rat hippocampal slices.
Neuropharmacology 2005;48(6):869-80.
2005: Jian-Hong Peng; John D Fryer; Raymond S Hurst; Katherine M Schroeder; Andrew A George; Steven Morrissy; Vincent E Groppi; Sherry S Leonard; Ronald J. Lukas
High-affinity epibatidine binding of functional, human alpha7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells.
The Journal of pharmacology and experimental therapeutics 2005;313(1):24-35.
2005: Vladimir P Grinevich; Sharon R Letchworth; Kari A Lindenberger; Jean Menager; Veronique Mary; Khalima A Sadieva; Lori M Buhlman; Georg Andrees Bohme; Laurent Pradier; Jesus Benavides; Ronald J. Lukas; Merouane Bencherif
Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit.
The Journal of pharmacology and experimental therapeutics 2005;312(2):619-26.
2004: Jie Wu; Andrew A George; Katherine M Schroeder; Lin Xu; Syndia Marxer-Miller; Linda Lucero; Ronald J. Lukas
Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons.
The Journal of pharmacology and experimental therapeutics 2004;311(1):80-91.
2004: Jie Wu; Yen-Ping Kuo; Andrew A George; Lin Xu; Jun Hu; Ronald J. Lukas
beta-Amyloid directly inhibits human alpha4beta2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells.
The Journal of biological chemistry 2004;279(36):37842-51.
2004: M Imad Damaj; Frank carroll; J Brek Eaton; Hernán A Navarro; Bruce E Blough; Sadiq Mirza; Ronald J. Lukas; Billy R Martin
Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors.
Molecular pharmacology 2004;66(3):675-82.
2003: J Brek Eaton; Jian-Hong Peng; Katherine M Schroeder; Andrew A George; John D Fryer; Chandra Krishnan; Lori Buhlman; Yen-Ping Kuo; Ortrud Steinlein; Ronald J. Lukas
Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells.
Molecular pharmacology 2003;64(6):1283-94.
2003: Lingke Zhao; Yen-Ping Kuo; Andrew A George; Jian-Hong Peng; Madhuri Singh Purandare; Katherine M Schroeder; Ronald J. Lukas; Jie Wu
Functional properties of homomeric, human alpha 7-nicotinic acetylcholine receptors heterologously expressed in the SH-EP1 human epithelial cell line.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1132-41.
2003: Travis Dunkley; Ronald J. Lukas
Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line.
The Journal of biological chemistry 2003;278(18):15633-40.
2003: Katherine M Schroeder; Jie Wu; Lingke Zhao; Ronald J. Lukas
Regulation by cycloheximide and lowered temperature of cell-surface alpha7-nicotinic acetylcholine receptor expression on transfected SH-EP1 cells.
Journal of neurochemistry 2003;85(3):581-91.
2003: Yvonne Slater; Lee M Houlihan; Peter D Maskell; Richard Exley; Isabel Bermúdez; Ronald J. Lukas; A C Valdivia; Bruce K Cassels
Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes.
Neuropharmacology 2003;44(4):503-15.
2003: Travis Dunkley; J Wu; L Zhao; Ronald J. Lukas
Mutational analysis of roles for extracellular cysteine residues in the assembly and function of human alpha 7-nicotinic acetylcholine receptors.
Biochemistry 2003;42(4):870-6.
2003: Cynthia L Gentry; Lincoln H Wilkins; Ronald J. Lukas
Effects of prolonged nicotinic ligand exposure on function of heterologously expressed, human alpha4beta2- and alpha4beta4-nicotinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 2003;304(1):206-16.
2002: Mary B Newman; Yen-Ping Kuo; Ronald J. Lukas; Paul Sanberg; R Douglas Shytle; Michael P McGrogan; Tanja Zigova
Nicotinic acetylcholine receptors on NT2 precursor cells and hNT (NT2-N) neurons.
Brain research. Developmental brain research 2002;139(1):73-86.
2002: Aaron J Middlebrook; Cherie Martina; Yung Chang; Ronald J. Lukas; Dominick DeLuca
Effects of nicotine exposure on T cell development in fetal thymus organ culture: arrest of T cell maturation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):2915-24.
2002: Yen Kuo; Linda Lucero; Jennifer Michaels; Dominick DeLuca; Ronald J. Lukas
Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.
Journal of neuroimmunology 2002;130(1-2):140-54.
2002: Yvonne Slater; Lee M Houlihan; Bruce K Cassels; Ronald J. Lukas; Isabel Bermúdez
Effects of the plant alkaloid tetrandrine on human nicotinic acetylcholine receptors.
European journal of pharmacology 2002;450(3):213-21.
2002: Cynthia L Gentry; Ronald J. Lukas
Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure.
Current drug targets. CNS and neurological disorders 2002;1(4):359-85.
2002: Marwan Sabbagh; Ronald J. Lukas; D Larry Sparks; Richard T Reid
The nicotinic acetylcholine receptor, smoking, and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2002;4(4):317-25.
2002: Ronald J. Lukas; Kemmons A. Tubbs; Arcadius V Krivoshein; Allan L Bieber; Randall W Nelson
Mass spectrometry of nicotinic acetylcholine receptors and associated proteins as models for complex transmembrane proteins.
Analytical biochemistry 2002;301(2):175-88.
2002: R Douglas Shytle; Archie A Silver; Ronald J. Lukas; Mary B Newman; David V Sheehan; Paul Sanberg
Nicotinic acetylcholine receptors as targets for antidepressants.
Molecular psychiatry 2002;7(6):525-35.
2001: Cynthia L Gentry; Ronald J. Lukas
Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes.
The Journal of pharmacology and experimental therapeutics 2001;299(3):1038-48.
2001: Lee M Houlihan; Yvonne Slater; D L Guerra; Jian-Hong Peng; Yen-Ping Kuo; Ronald J. Lukas; Bruce K Cassels; Isabel Bermudez
Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors.
Journal of neurochemistry 2001;78(5):1029-43.
2001: Mary A Pacheco; Tina E Pastoor; Ronald J. Lukas; Lynn Wecker
Characterization of human alpha4beta2 neuronal nicotinic receptors stably expressed in SH-EP1 cells.
Neurochemical research 2001;26(6):683-93.
2001: Ronald J. Lukas; Linda Lucero; B Buisson; Jean-Luc Galzi; E Puchacz; John D Fryer; Jean-Pierre Changeux; Daniel Bertrand
Neurotoxicity of channel mutations in heterologously expressed alpha7-nicotinic acetylcholine receptors.
The European journal of neuroscience 2001;13(10):1849-60.
2001: Pedro A Ferchmin; Ronald J. Lukas; Richard M Hann; John D Fryer; J Brek Eaton; One R Pagan; Abimael D Rodriguez; Y Nicolau; M Rosado; S Cortés; V A Eterović
Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function.
Journal of neuroscience research 2001;64(1):18-25.
2000: Lee M Houlihan; E Y Slater; David J Beadle; Ronald J. Lukas; Isabel Bermudez
Effects of diltiazem on human nicotinic acetylcholine and GABA(A) receptors.
Neuropharmacology 2000;39(13):2533-42.
2000: D Larry Sparks; Yu-Min Kuo; Alex Roher; T Martin; Ronald J. Lukas
Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations.
Annals of the New York Academy of Sciences 2000;903():335-44.
2000: Michael P Blanton; Elizabeth A McCardy; John D Fryer; M Liu; Ronald J. Lukas
5-hydroxytryptamine interaction with the nicotinic acetylcholine receptor.
European journal of pharmacology 2000;389(2-3):155-63.
1999: Ronald J. Lukas; Jean-Pierre Changeux; N Le Novère; Edson X Albuquerque; David J K Balfour; D K Berg; D Bertrand; V A Chiappinelli; P B Clarke; A C Collins; J A Dani; Sharon R Grady; K J Kellar; Jon M Lindstrom; M J Marks; Maryka Quik; P W Taylor; S Wonnacott
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.
Pharmacological reviews 1999;51(2):397-401.
1999: R Reitstetter; Ronald J. Lukas; Raphael Gruener
Dependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure.
The Journal of pharmacology and experimental therapeutics 1999;289(2):656-60.
1999: Jian-Hong Peng; Linda Lucero; J Fryer; J Herl; Sherry S Leonard; Ronald J. Lukas
Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line.
Brain research 1999;825(1-2):172-9.
1999: John D Fryer; Ronald J. Lukas
Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function.
Journal of neurochemistry 1999;72(3):1117-24.
1999: John D Fryer; Ronald J. Lukas
Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine.
The Journal of pharmacology and experimental therapeutics 1999;288(1):88-92.
1998: D Larry Sparks; Thomas Beach; Ronald J. Lukas
Immunohistochemical localization of nicotinic beta2 and alpha4 receptor subunits in normal human brain and individuals with Lewy body and Alzheimer's disease: preliminary observations.
Neuroscience letters 1998;256(3):151-4.
1998: L Ke; C M Eisenhour; Merouane Bencherif; Ronald J. Lukas
Effects of chronic nicotine treatment on expression of diverse nicotinic acetylcholine receptor subtypes. I. Dose- and time-dependent effects of nicotine treatment.
The Journal of pharmacology and experimental therapeutics 1998;286(2):825-40.
1996: Ronald J. Lukas; C M Eisenhour
Interactions between tachykinins and diverse, human nicotinic acetylcholine receptor subtypes.
Neurochemical research 1996;21(10):1245-57.
1996: L Ke; Ronald J. Lukas
Effects of steroid exposure on ligand binding and functional activities of diverse nicotinic acetylcholine receptor subtypes.
Journal of neurochemistry 1996;67(3):1100-12.
1996: M Quik; J Choremis; J Komourian; Ronald J. Lukas; E Puchacz
Similarity between rat brain nicotinic alpha-bungarotoxin receptors and stably expressed alpha-bungarotoxin binding sites.
Journal of neurochemistry 1996;67(1):145-54.
1995: Merouane Bencherif; C M Eisenhour; R J Prince; P M Lippiello; Ronald J. Lukas
The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester] is a potent, non-competitive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1418-26.
1995: Merouane Bencherif; K Fowler; Ronald J. Lukas; P M Lippiello
Mechanisms of up-regulation of neuronal nicotinic acetylcholine receptors in clonal cell lines and primary cultures of fetal rat brain.
The Journal of pharmacology and experimental therapeutics 1995;275(2):987-94.
1995: R A Cooper; J C de Freitas; F Porreca; C M Eisenhour; Ronald J. Lukas; RJ Huxtable
The sea anemone purine, caissarone: adenosine receptor antagonism.
Toxicon : official journal of the International Society on Toxinology 1995;33(8):1025-31.
1995: Ronald J. Lukas
Diversity and patterns of regulation of nicotinic receptor subtypes.
Annals of the New York Academy of Sciences 1995;757():153-68.
1994: E Puchacz; B Buisson; D Bertrand; Ronald J. Lukas
Functional expression of nicotinic acetylcholine receptors containing rat alpha 7 subunits in human SH-SY5Y neuroblastoma cells.
FEBS letters 1994;354(2):155-9.
1993: Ronald J. Lukas; L Lucero; T Audhya; G Goldstein
Notice of retraction.
Molecular pharmacology 1993;44(3):680.
1993: Merouane Bencherif; Ronald J. Lukas
Cytochalasin modulation of nicotinic cholinergic receptor expression and muscarinic receptor function in human TE671/RD cells: a possible functional role of the cytoskeleton.
Journal of neurochemistry 1993;61(3):852-64.
1993: E Puchacz; Ewa K Stachowiak; R Z Florkiewicz; Ronald J. Lukas; Michal K Stachowiak
Basic fibroblast growth factor (bFGF) regulates tyrosine hydroxylase and proenkephalin mRNA levels in adrenal chromaffin cells.
Brain research 1993;610(1):39-52.
1993: Ronald J. Lukas
Expression of ganglia-type nicotinic acetylcholine receptors and nicotinic ligand binding sites by cells of the IMR-32 human neuroblastoma clonal line.
The Journal of pharmacology and experimental therapeutics 1993;265(1):294-302.
1993: Ronald J. Lukas; S A Norman; Linda Lucero
Characterization of Nicotinic Acetylcholine Receptors Expressed by Cells of the SH-SY5Y Human Neuroblastoma Clonal Line.
Molecular and cellular neurosciences 1993;4(1):1-12.
1993: A M Joy; H N Siegel; Ronald J. Lukas
Photoaffinity labeling of muscle-type nicotinic acetylcholine receptors and neuronal/nicotinic alpha-bungarotoxin binding sites with a derivative of alpha-bungarotoxin.
Brain research. Molecular brain research 1993;17(1-2):95-100.
1992: A Goc; S A Norman; E Puchacz; E K Stachowiak; Ronald J. Lukas; M K Stachowiak
A 5'-flanking region of the bovine tyrosine hydroxylase gene is involved in cell-specific expression, activation of gene transcription by phorbol ester, and transactivation by c-Fos and c-Jun.
Molecular and cellular neurosciences 1992;3(5):383-94.
1992: Merouane Bencherif; Ronald J. Lukas
Vanadate amplifies receptor-mediated accumulation of inositol trisphosphates and inhibits inositol tris- and tetrakis-phosphatase activities.
Neuroscience letters 1992;134(2):157-60.
1992: Ronald J. Lukas; Merouane Bencherif
Heterogeneity and regulation of nicotinic acetylcholine receptors.
International review of neurobiology 1992;34():25-131.
1991: Merouane Bencherif; Ronald J. Lukas
Differential sensitivity of phosphoinositide metabolism to sodium fluoride and carbachol treatments in PC12 cells.
Molecular and cellular neurosciences 1991;2(5):377-83.
1991: Merouane Bencherif; Ronald J. Lukas
Ligand binding and functional characterization of muscarinic acetylcholine receptors on the TE671/RD human cell line.
The Journal of pharmacology and experimental therapeutics 1991;257(3):946-53.
1991: Ronald J. Lukas
Effects of chronic nicotinic ligand exposure on functional activity of nicotinic acetylcholine receptors expressed by cells of the PC12 rat pheochromocytoma or the TE671/RD human clonal line.
Journal of neurochemistry 1991;56(4):1134-45.
1991: Merouane Bencherif; Ronald J. Lukas
Differential regulation of nicotinic acetylcholine receptor expression by human TE671/RD cells following second messenger modulation and sodium butyrate treatments.
Molecular and cellular neurosciences 1991;2(1):52-65.
1990: Ronald J. Lukas; T Audhya; G Goldstein; L Lucero
Interactions of the thymic polypeptide hormone thymopoietin with neuronal nicotinic alpha-bungarotoxin binding sites and with muscle-type, but not ganglia-type, nicotinic acetylcholine receptor ligand-gated ion channels.
Molecular pharmacology 1990;38(6):887-94.
1990: Ronald J. Lukas
Heterogeneity of high-affinity nicotinic [3H]acetylcholine binding sites.
The Journal of pharmacology and experimental therapeutics 1990;253(1):51-7.
1989: Ronald J. Lukas
Pharmacological distinctions between functional nicotinic acetylcholine receptors on the PC12 rat pheochromocytoma and the TE671 human medulloblastoma.
The Journal of pharmacology and experimental therapeutics 1989;251(1):175-82.
1989: Robert E Oswald; R L Papke; Ronald J. Lukas
Characterization of nicotinic acetylcholine receptor channels of the TE671 human medulloblastoma clonal line.
Neuroscience letters 1989;96(2):207-12.
1989: Ronald J. Lukas
Nicotinic acetylcholine receptor diversity: agonist binding and functional potency.
Progress in brain research 1989;79():117-27.
1988: H N Siegel; Ronald J. Lukas
Morphological and biochemical differentiation of the human medulloblastoma cell line TE671.
Brain research. Developmental brain research 1988;44(2):269-80.
1988: Ronald J. Lukas; M J Cullen
An isotopic rubidium ion efflux assay for the functional characterization of nicotinic acetylcholine receptors on clonal cell lines.
Analytical biochemistry 1988;175(1):212-8.
1988: H N Siegel; Ronald J. Lukas
Nicotinic agonists regulate alpha-bungarotoxin binding sites of TE671 human medulloblastoma cells.
Journal of neurochemistry 1988;50(4):1272-8.
1986: Ronald J. Lukas
Characterization of curaremimetic neurotoxin binding sites on cellular membrane fragments derived from the rat pheochromocytoma PC12.
Journal of neurochemistry 1986;47(6):1768-73.
1986: Ronald J. Lukas
Interactions of anti-nicotinic acetylcholine receptor antibodies at alpha-bungarotoxin binding sites across species and tissues.
Brain research 1986;387(2):119-25.
1986: Ronald J. Lukas
Interactions of antinicotinic acetylcholine receptor antibodies with rat brain and muscle antigenic determinants.
Cellular and molecular neurobiology 1986;6(3):281-91.
1986: Ronald J. Lukas
Immunochemical and pharmacological distinctions between curaremimetic neurotoxin binding sites of central, autonomic, and peripheral origin.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(15):5741-5.
1986: H N Siegel; Ronald J. Lukas
Allosteric modification of alpha-bungarotoxin binding by the 'calcium channel antagonist' verapamil.
Brain research 1986;387(1):37-42.
1986: Ronald J. Lukas
Characterization of curaremimetic neurotoxin binding sites on membrane fractions derived from the human medulloblastoma clonal line, TE671.
Journal of neurochemistry 1986;46(6):1936-41.
1986: Ronald J. Lukas
Interactions of polyclonal anti-Electrophorus nicotinic receptor antisera with Torpedo nicotinic receptor.
The International journal of biochemistry 1986;18(7):609-15.
1984: Ronald J. Lukas
Monoclonal rat anti-Torpedo electroplax nicotinic acetylcholine receptor antibodies: immunochemical characterization.
Journal of immunological methods 1984;74(1):129-38.
1984: Ronald J. Lukas
Detection of low-affinity alpha-bungarotoxin binding sites in the rat central nervous system.
Biochemistry 1984;23(6):1160-4.
1984: Ronald J. Lukas
Properties of curaremimetic neurotoxin binding sites in the rat central nervous system.
Biochemistry 1984;23(6):1152-60.
1981: Ronald J. Lukas; H Morimoto; M R Hanley; E L Bennett
Radiolabeled alpha-bungarotoxin derivatives: kinetic interaction with nicotinic acetylcholine receptors.
Biochemistry 1981;20(26):7373-8.
1981: J W Walker; Ronald J. Lukas; M G McNamee
Effects of thio-group modifications on the ion permeability control and ligand binding properties of Torpedo californica acetylcholine receptor.
Biochemistry 1981;20(8):2191-9.
1980: Ronald J. Lukas; E L Bennett
Chemical modification and reactivity of sulfhydryls and disulfides of rat brain nicotinic-like acetylcholine receptors.
The Journal of biological chemistry 1980;255(12):5573-7.
1980: Ronald J. Lukas; E L Bennett
Interaction of nicotinic receptor affinity reagents with central nervous system alpha-bungarotoxin-binding entities.
Molecular pharmacology 1980;17(2):149-55.
1979: Ronald J. Lukas; E L Bennett
Effects of local anesthetics on cholinergic agonist binding affinity of central nervous system alpha-bungarotoxin receptors.
FEBS letters 1979;108(2):356-8.
1979: Ronald J. Lukas; E L Bennett
Agonist-induced affinity alterations of a central nervous system alpha-bungarotoxin receptor.
Journal of neurochemistry 1979;33(6):1151-7.
1979: Ronald J. Lukas; H Morimoto; E L Bennett
Effects of thio-group modification and Ca2+ on agonist-specific state transitions of a central nicotinic acetylcholine receptor.
Biochemistry 1979;18(11):2384-95.
1979: J V Miller; Ronald J. Lukas; E L Bennett
Effects of thiol modification and Ca++ on agonist-specific state transitions of nicotinic acetylcholine receptor from Torpedo californica electroplax.
Life sciences 1979;24(20):1893-9.