FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Lawrence J. Manderino

Research Profile

Chemicals & Drugs

Disorders

Anatomy

Physiology

Concepts & Ideas

Reference Values

Living Beings

Rats

Co-author Network

Publications

TOP 3
Paul Langlais; M Luo; Elena A De Filippis; J Finlayson; R Mapes; M Mattern; C Meyer; E Plummer; P Tongchinsub; Zhengping Yi; Lawrence J. Manderino
Global IRS-1 phosphorylation analysis in insulin resistance.
Sangeeta Ghosh; Joaquin Joya-Galeana; Natalie Lefort; Raweewan Lertwattanarak; Lawrence J. Manderino; Marjorie Molina-Carrion; Muhammad Abdul-Ghani; Benjamin P Bowen; Ralph DeFronzo; Jose de Jesus Garduno-Garcia; Arlan G Richardson; Holly Van Remmen; Nicolas Musi
Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance.
R M Holmes; H Hwang; Lawrence J. Manderino; C Meyer; P Sathyanarayana; S Shahani; V Sherman; Z Yi; Rachele Berria; Christine Y Christ-Roberts; Elena A De Filippis; Lily Dong; J Finlayson; K Fujiwara; Mandeep Bajaj
Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Lawrence J. Manderino (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: Paul Langlais; M Luo; Elena A De Filippis; J Finlayson; R Mapes; M Mattern; C Meyer; E Plummer; P Tongchinsub; Zhengping Yi; Lawrence J. Manderino
Global IRS-1 phosphorylation analysis in insulin resistance.
Diabetologia 2011;54(11):2878-89.
2011: Sangeeta Ghosh; Joaquin Joya-Galeana; Natalie Lefort; Raweewan Lertwattanarak; Lawrence J. Manderino; Marjorie Molina-Carrion; Muhammad Abdul-Ghani; Benjamin P Bowen; Ralph DeFronzo; Jose de Jesus Garduno-Garcia; Arlan G Richardson; Holly Van Remmen; Nicolas Musi
Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance.
Diabetes 2011;60(8):2051-60.
2011: R M Holmes; H Hwang; Lawrence J. Manderino; C Meyer; P Sathyanarayana; S Shahani; V Sherman; Z Yi; Rachele Berria; Christine Y Christ-Roberts; Elena A De Filippis; Lily Dong; J Finlayson; K Fujiwara; Mandeep Bajaj
Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling.
Diabetologia 2011;54(8):2122-31.
2011: Guilherme M Puga; Sarah Everman; Lawrence J. Manderino; Christian Meyer; Christos S Katsanos
Postprandial lipemia in the elderly involves increased incorporation of ingested fat in plasma free fatty acids and small (Sf 20-400) triglyceride-rich lipoproteins.
American journal of physiology. Endocrinology and metabolism 2011;301(2):E356-61.
2011: Paul Langlais; Zhengping Yi; Lawrence J. Manderino
The identification of raptor as a substrate for p44/42 MAPK.
Endocrinology 2011;152(4):1264-73.
2011: Thangiah Geetha; Paul Langlais; Moulun Luo; Rebekka Mapes; Natalie Lefort; Shu-Chuan Chen; Lawrence J. Manderino; Zhengping Yi
Label-free proteomic identification of endogenous, insulin-stimulated interaction partners of insulin receptor substrate-1.
Journal of the American Society for Mass Spectrometry 2011;22(3):457-66.
2011: Christos S Katsanos; Lawrence J. Manderino
Protein metabolism in human obesity: a shift in focus from whole-body to skeletal muscle.
Obesity (Silver Spring, Md.) 2011;19(3):469-75.
2010: Sangeeta R Kashyap; Linda Roman; Lawrence J. Manderino; Ralph DeFronzo; Mandeep Bajaj
Hypoadiponectinemia is closely associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.
Metabolic syndrome and related disorders 2010;8(5):459-63.
2010: Natalie Lefort; Brian Glancy; Benjamin Bowen; Wayne T Willis; Zachary Bailowitz; Elena A De Filippis; Colleen Brophy; Christian Meyer; Kurt Højlund; Zhengping Yi; Lawrence J. Manderino
Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle.
Diabetes 2010;59(10):2444-52.
2010: Xitao Xie; Zhengping Yi; Benjamin Bowen; Cassandra Wolf; Charles R Flynn; Sandeep Sinha; Lawrence J. Manderino; Christian Meyer
Characterization of the Human Adipocyte Proteome and Reproducibility of Protein Abundance by One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS.
Journal of proteome research 2010;9(9):4521-34.
2010: Paul Langlais; Lawrence J. Manderino; Zhengping Yi
Label-free relative quantification of co-eluting isobaric phosphopeptides of insulin receptor substrate-1 by HPLC-ESI-MS/MS.
Journal of the American Society for Mass Spectrometry 2010;21(9):1490-9.
2010: Anthony E Civitarese; Paul S MacLean; Stacy Carling; Lyndal Kerr-Bayles; Ryan P McMillan; Anson Pierce; Thomas C Becker; Cedric Moro; Jean Finlayson; Natalie Lefort; Christopher B Newgard; Lawrence J. Manderino; William Cefalu; Ken Walder; Greg R Collier; Matthew W Hulver; Steven R Smith; Eric Ravussin
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.
Cell metabolism 2010;11(5):412-26.
2010: Kurt Højlund; Z Yi; N Lefort; P Langlais; B Bowen; K Levin; H Beck-Nielsen; Lawrence J. Manderino
Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle.
Diabetologia 2010;53(3):541-51.
2010: Hyonson Hwang; Benjamin P Bowen; Natalie Lefort; Charles R Flynn; Elena A De Filippis; Christine Roberts; Christopher C Smoke; Christian Meyer; Kurt Højlund; Zhengping Yi; Lawrence J. Manderino
Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes.
Diabetes 2010;59(1):33-42.
2009: Kurt Højlund; Benjamin P Bowen; Hyonson Hwang; Charles R Flynn; Lohith Madireddy; Thangiah Geetha; Paul Langlais; Christian Meyer; Lawrence J. Manderino; Zhengping Yi
In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS.
Journal of proteome research 2009;8(11):4954-65.
2009: Natalie Lefort; Zhengping Yi; Benjamin Bowen; Brian Glancy; Elena A De Filippis; Rebekka Mapes; Hyonson Hwang; Charles R Flynn; Wayne T Willis; Anthony Civitarese; Kurt Højlund; Lawrence J. Manderino
Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.
Journal of proteomics 2009;72(6):1046-60.
2008: Zhengping Yi; Benjamin P Bowen; Hyonson Hwang; Christopher Jenkinson; Dawn K Coletta; Natalie Lefort; Mandeep Bajaj; Sangeeta Kashyap; Rachele Berria; Elena A De Filippis; Lawrence J. Manderino
Global relationship between the proteome and transcriptome of human skeletal muscle.
Journal of proteome research 2008;7(8):3230-41.
2008: Dawn K Coletta; Bogdan Balas; Alberto O Chavez; Muhammad Baig; Muhammad Abdul-Ghani; Sangeeta Kashyap; Franco Folli; Devjit Tripathy; Lawrence J. Manderino; John Cornell; Ralph DeFronzo; Christopher Jenkinson
Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E910-7.
2008: Elena A De Filippis; Guy Alvarez; Rachele Berria; Kenneth Cusi; Sarah Everman; Christian Meyer; Lawrence J. Manderino
Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise.
American journal of physiology. Endocrinology and metabolism 2008;294(3):E607-14.
2008: Kurt Højlund; Zhengping Yi; Hyonson Hwang; Benjamin Bowen; Natalie Lefort; Charles R Flynn; Paul Langlais; Susan Weintraub; Lawrence J. Manderino
Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.
Molecular & cellular proteomics : MCP 2008;7(2):257-67.
2007: Moulun Luo; Paul Langlais; Zhengping Yi; Natalie Lefort; Elena A De Filippis; Hyonson Hwang; Christine Y Christ-Roberts; Lawrence J. Manderino
Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling.
Endocrinology 2007;148(10):4895-905.
2007: Torben Østergård; Niels Jessen; Ole Schmitz; Lawrence J. Manderino
The effect of exercise, training, and inactivity on insulin sensitivity in diabetics and their relatives: what is new?
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2007;32(3):541-8.
2007: Zhengping Yi; Paul Langlais; Elena A De Filippis; Moulun Luo; Charles R Flynn; Stefanie Schroeder; Susan Weintraub; Rebekka Mapes; Lawrence J. Manderino
Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle.
Diabetes 2007;56(6):1508-16.
2007: Mandeep Bajaj; Rafael Medina-Navarro; Swangjit Suraamornkul; Christian Meyer; Ralph DeFronzo; Lawrence J. Manderino
Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration.
Diabetes 2007;56(3):743-52.
2007: Charles R Flynn; Christopher C Smoke; Elizabeth J Furnish; Padmini Komalavilas; Jeffrey S Thresher; Zhengping Yi; Lawrence J. Manderino; Colleen M Brophy
Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli.
Protein expression and purification 2007;52(1):50-8.
2007: Merri L Pendergrass; Alessandra Bertoldo; Riccardo Bonadonna; Gianluca Nucci; Lawrence J. Manderino; Claudio Cobelli; Ralph DeFronzo
Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E92-100.
2006: Elena A De Filippis; Kenneth Cusi; Gloria Ocampo; Rachele Berria; Susan Buck; agostino consoli; Lawrence J. Manderino
Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2006;91(12):4903-10.
2006: Anthony E Civitarese; Barbara Ukropcova; Stacy Carling; Matthew W Hulver; Ralph DeFronzo; Lawrence J. Manderino; Eric Ravussin; Steven R Smith
Role of adiponectin in human skeletal muscle bioenergetics.
Cell metabolism 2006;4(1):75-87.
2006: Betty A Maddux; Adelene Chan; Elena A De Filippis; Lawrence J. Manderino; Ira D Goldfine
IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance.
Diabetes care 2006;29(7):1535-7.
2006: Apiradee Sriwijitkamol; John L Ivy; Christine Y Christ-Roberts; Ralph DeFronzo; Lawrence J. Manderino; Nicolas Musi
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E925-32.
2006: Zhengping Yi; Moulun Luo; Lawrence J. Manderino; Sara M Reyna; Christopher A Carroll; Susan Weintraub
Quantification of phosphorylation of insulin receptor substrate-1 by HPLC-ESI-MS/MS.
Journal of the American Society for Mass Spectrometry 2006;17(4):562-7.
2006: Apiradee Sriwijitkamol; Christine Y Christ-Roberts; Rachele Berria; Phyllis A Eagan; Thongchai Pratipanawatr; Ralph DeFronzo; Lawrence J. Manderino; Nicolas Musi
Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training.
Diabetes 2006;55(3):760-7.
2006: Rachele Berria; Lishan Wang; Dawn K Richardson; Jean Finlayson; Renata Belfort; Thongchai Pratipanawatr; Elena A De Filippis; Sangeeta Kashyap; Lawrence J. Manderino
Increased collagen content in insulin-resistant skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2006;290(3):E560-5.
2005: Mandeep Bajaj; Swangjit Suraamornkul; Anthony Romanelli; Gary W Cline; Lawrence J. Manderino; Gerald I Shulman; Ralph DeFronzo
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes 2005;54(11):3148-53.
2005: Moulun Luo; Sara M Reyna; Lishan Wang; Zhengping Yi; Christopher Carroll; Lily Dong; Paul Langlais; Susan Weintraub; Lawrence J. Manderino
Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.
Endocrinology 2005;146(10):4410-6.
2005: Zhengping Yi; Moulun Luo; Christopher A Carroll; Susan Weintraub; Lawrence J. Manderino
Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Analytical chemistry 2005;77(17):5693-9.
2005: Renata Belfort; Lawrence J. Manderino; Sangeeta Kashyap; Kelly Wirfel; Thongchai Pratipanawatr; Rachele Berria; Ralph DeFronzo; Kenneth Cusi
Dose-response effect of elevated plasma free fatty acid on insulin signaling.
Diabetes 2005;54(6):1640-8.
2005: Dawn K Richardson; Sangeeta Kashyap; Mandeep Bajaj; Kenneth Cusi; Steven J Mandarino; Jean Finlayson; Ralph DeFronzo; Christopher Jenkinson; Lawrence J. Manderino
Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.
The Journal of biological chemistry 2005;280(11):10290-7.
2005: Ken Walder; Lyndal Kerr-Bayles; Anthony E Civitarese; Jeremy B M Jowett; Joanne E Curran; K Elliott; James Trevaskis; Natalie Bishara; Paul Zimmet; Lawrence J. Manderino; Eric Ravussin; John C Blangero; Ahmed H Kissebah; Greg R Collier
The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes.
Diabetologia 2005;48(3):459-68.
2004: Mandeep Bajaj; Swangjit Suraamornkul; Sangeeta Kashyap; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2004;89(9):4649-55.
2004: Yoshinori Miyazaki; Archana Mahankali; Estela Wajcberg; Mandeep Bajaj; Lawrence J. Manderino; Ralph DeFronzo
Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2004;89(9):4312-9.
2004: Christine Y Christ-Roberts; Thongchai Pratipanawatr; Wilailak Pratipanawatr; Rachele Berria; Renata Belfort; Sangeeta Kashyap; Lawrence J. Manderino
Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects.
Metabolism: clinical and experimental 2004;53(9):1233-42.
2004: Sangeeta Kashyap; Renata Belfort; Rachele Berria; Swangjit Suraamornkul; Thongchai Pratipranawatr; Jean Finlayson; Andrea Barrentine; Mandeep Bajaj; Lawrence J. Manderino; Ralph DeFronzo; Kenneth Cusi
Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2004;287(3):E537-46.
2004: Christine Y Christ-Roberts; Lawrence J. Manderino
Glycogen synthase: key effect of exercise on insulin action.
Exercise and sport sciences reviews 2004;32(3):90-4.
2004: Mandeep Bajaj; Lawrence J. Manderino
Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes.
The New England journal of medicine 2004;350(23):2419-21; author reply 2419-21.
2004: Anthony E Civitarese; Christopher Jenkinson; D Richardson; Mandeep Bajaj; Kenneth Cusi; Sangeeta Kashyap; Rachele Berria; R Belfort; Ralph DeFronzo; Lawrence J. Manderino; Eric Ravussin
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Diabetologia 2004;47(5):816-20.
2004: Harold Bays; Lawrence J. Manderino; Ralph DeFronzo
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach.
The Journal of clinical endocrinology and metabolism 2004;89(2):463-78.
2004: John M Adams; Thongchai Pratipanawatr; Rachele Berria; Elaine Wang; Ralph DeFronzo; M Cameron Sullards; Lawrence J. Manderino
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
Diabetes 2004;53(1):25-31.
2003: Christine Y Christ-Roberts; Thongchai Pratipanawatr; Wilailak Pratipanawatr; Rachele Berria; Renata Belfort; Lawrence J. Manderino
Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(6):2519-29.
2003: Sangeeta Kashyap; Renata Belfort; Amalia Gastaldelli; Thongchai Pratipanawatr; Rachele Berria; Wilailak Pratipanawatr; Mandeep Bajaj; Lawrence J. Manderino; Ralph DeFronzo; Kenneth Cusi
A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.
Diabetes 2003;52(10):2461-74.
2003: Yoshinori Miyazaki; Helen He; Lawrence J. Manderino; Ralph DeFronzo
Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients.
Diabetes 2003;52(8):1943-50.
2003: Mary-Elizabeth Patti; Atul Butte; Sarah Crunkhorn; Kenneth Cusi; Rachele Berria; Sangeeta Kashyap; Yoshinori Miyazaki; Isaac Kohane; Maura Costello; Robert Saccone; Edwin J Landaker; Allison B Goldfine; Edward C Mun; Ralph DeFronzo; Jean Finlayson; C Ronald Kahn; Lawrence J. Manderino
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8466-71.
2003: Yoshinori Miyazaki; R Pipek; Lawrence J. Manderino; Ralph DeFronzo
Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(1):88-94.
2002: Yoshinori Miyazaki; Leonard Glass; Curtis Triplitt; Estela Wajcberg; Lawrence J. Manderino; Ralph DeFronzo
Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus.
American journal of physiology. Endocrinology and metabolism 2002;283(6):E1135-43.
2002: Mandeep Bajaj; Thongchai Pratipanawatr; Rachele Berria; Wilailak Pratipanawatr; Sangeeta Kashyap; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes.
Diabetes 2002;51(10):3043-8.
2002: Mandeep Bajaj; Rachele Berria; Thongchai Pratipanawatr; Sangeeta Kashyap; Wilailak Pratipanawatr; Renata Belfort; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans.
American journal of physiology. Endocrinology and metabolism 2002;283(2):E346-52.
2002: Yoshinori Miyazaki; Archana Mahankali; Masafumi Matsuda; Srikanth Mahankali; Jean Hardies; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2002;87(6):2784-91.
2002: Thongchai Pratipanawatr; Wilailak Pratipanawatr; Clifford Rosen; Rachele Berria; Mandeep Bajaj; Kenneth Cusi; Lawrence J. Manderino; Sangeeta Kashyap; Renata Belfort; Ralph DeFronzo
Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1360-8.
2002: N A Lee; Masafumi Matsuda; Peter Bressler; Thongchai Pratipanawatr; Leonard Glass; Lawrence J. Manderino; Ralph DeFronzo
Effect of misoprostol (PGE1) on glucose metabolism in type-2-diabetic and control subjects.
Diabetes, obesity & metabolism 2002;4(3):195-200.
2002: Thongchai Pratipanawatr; Kenneth Cusi; Peter Ngo; Wilailak Pratipanawatr; Lawrence J. Manderino; Ralph DeFronzo
Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes.
Diabetes 2002;51(2):462-8.
2002: Christine Y Christ; Desmond Hunt; Joe Hancock; Rebeca Garcia-Macedo; Lawrence J. Manderino; John L Ivy
Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(2):736-44.
2001: Yoshinori Miyazaki; Leonard Glass; Curtis Triplitt; Masafumi Matsuda; Kenneth Cusi; Archana Mahankali; Srikanth Mahankali; Lawrence J. Manderino; Ralph DeFronzo
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients.
Diabetologia 2001;44(12):2210-9.
2001: Wilailak Pratipanawatr; Thongchai Pratipanawatr; Kenneth Cusi; Rachele Berria; J M Adams; Christopher Jenkinson; K Maezono; Ralph DeFronzo; Lawrence J. Manderino
Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.
Diabetes 2001;50(11):2572-8.
2001: Kenneth Cusi; Thongchai Pratipanawatr; JA Koval; Richard L Printz; Hossein Ardehali; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.
Metabolism: clinical and experimental 2001;50(5):602-6.
2001: Patricia Iozzo; Thongchai Pratipanawatr; H Pijl; C Vogt; V Kumar; R Pipek; Masafumi Matsuda; Lawrence J. Manderino; Kenneth Cusi; Ralph DeFronzo
Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.
American journal of physiology. Endocrinology and metabolism 2001;280(5):E712-9.
2001: Yoshinori Miyazaki; Archana Mahankali; Masafumi Matsuda; Leonard Glass; Srikanth Mahankali; Ele Ferrannini; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone.
Diabetes care 2001;24(4):710-9.
2001: A A Osman; Joe Hancock; Desmond G Hunt; John L Ivy; Lawrence J. Manderino
Exercise training increases ERK2 activity in skeletal muscle of obese Zucker rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;90(2):454-60.
2000: C Vogt; Hossein Ardehali; Patricia Iozzo; Hannele Yki-Järvinen; JA Koval; K Maezono; Merri L Pendergrass; Richard L Printz; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Regulation of hexokinase II expression in human skeletal muscle in vivo.
Metabolism: clinical and experimental 2000;49(6):814-8.
2000: A A Osman; Merri L Pendergrass; JA Koval; K Maezono; Kenneth Cusi; Thongchai Pratipanawatr; Lawrence J. Manderino
Regulation of MAP kinase pathway activity in vivo in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;278(6):E992-9.
2000: David E Kelley; Lawrence J. Manderino
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Diabetes 2000;49(5):677-83.
2000: Kenneth Cusi; K Maezono; A Osman; Merri L Pendergrass; Mary-Elizabeth Patti; Thongchai Pratipanawatr; Ralph DeFronzo; C R Kahn; Lawrence J. Manderino
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.
The Journal of clinical investigation 2000;105(3):311-20.
1999: JA Koval; K Maezono; Mary-Elizabeth Patti; Merri L Pendergrass; Ralph DeFronzo; Lawrence J. Manderino
Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle.
Medicine and science in sports and exercise 1999;31(7):998-1004.
1999: Masafumi Matsuda; Lawrence J. Manderino; Ralph DeFronzo
Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats.
Metabolism: clinical and experimental 1999;48(6):725-31.
1998: Sietse Jan Koopmans; Lawrence J. Manderino; Ralph DeFronzo
Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats.
The American journal of physiology 1998;274(4 Pt 1):E642-50.
1998: Merri L Pendergrass; JA Koval; C Vogt; H Yki-Jarvinen; Patricia Iozzo; R Pipek; Hossein Ardehali; Richard L Printz; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Diabetes 1998;47(3):387-94.
1998: JA Koval; Ralph DeFronzo; RM O'Doherty; Richard L Printz; Hossein Ardehali; Daryl K Granner; Lawrence J. Manderino
Regulation of hexokinase II activity and expression in human muscle by moderate exercise.
The American journal of physiology 1998;274(2 Pt 1):E304-8.
1998: C Vogt; H Yki-Jarvinen; Patricia Iozzo; R Pipek; Merri L Pendergrass; JA Koval; Hossein Ardehali; Richard L Printz; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo.
The Journal of clinical endocrinology and metabolism 1998;83(1):230-4.
1997: Lily Dong; H Du; S G Porter; L F Kolakowski; A V Lee; Lawrence J. Manderino; J Fan; D Yee; Feng Liu; J Mandarino
Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.
The Journal of biological chemistry 1997;272(46):29104-12.
1997: Sietse Jan Koopmans; L Ohman; Joseph Roscoe Haywood; Lawrence J. Manderino; Ralph DeFronzo
Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats.
Diabetes 1997;46(10):1572-8.
1997: Hannele Yki-Järvinen; C Vogt; Patricia Iozzo; R Pipek; MC Daniels; Antti Virkamäki; Sari Mäkimattila; Lawrence J. Manderino; Ralph DeFronzo; Donald A McClain; W K Gottschalk
UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.
Diabetologia 1997;40(1):76-81.
1996: Lawrence J. Manderino; agostino consoli; A Jain; David E Kelley
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM.
The American journal of physiology 1996;270(3 Pt 1):E463-70.
1995: Lawrence J. Manderino; Richard L Printz; Kenneth Cusi; P Kinchington; R M O'Doherty; H Osawa; C Sewell; agostino consoli; Daryl K Granner; Ralph DeFronzo
Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle.
The American journal of physiology 1995;269(4 Pt 1):E701-8.
1994: Lawrence J. Manderino; J Finlayson; J R Hassell
High glucose downregulates glucose transport activity in retinal capillary pericytes but not endothelial cells.
Investigative ophthalmology & visual science 1994;35(3):964-72.
1993: Lawrence J. Manderino; agostino consoli; A Jain; David E Kelley
Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle.
The American journal of physiology 1993;265(6 Pt 1):E898-905.
1993: Lawrence J. Manderino; N Sundarraj; J Finlayson; H R Hassell
Regulation of fibronectin and laminin synthesis by retinal capillary endothelial cells and pericytes in vitro.
Experimental eye research 1993;57(5):609-21.
1993: David E Kelley; M Mokan; Lawrence J. Manderino
Metabolic pathways of glucose in skeletal muscle of lean NIDDM patients.
Diabetes care 1993;16(8):1158-66.
1993: David E Kelley; M Mokan; Jean-Aimé Simoneau; Lawrence J. Manderino
Interaction between glucose and free fatty acid metabolism in human skeletal muscle.
The Journal of clinical investigation 1993;92(1):91-8.
1993: M Ohji; Lawrence J. Manderino; Nirmala SundarRaj; R A Thoft
Corneal epithelial cell attachment with endogenous laminin and fibronectin.
Investigative ophthalmology & visual science 1993;34(8):2487-92.
1992: Lawrence J. Manderino
Current hypotheses for the biochemical basis of diabetic retinopathy.
Diabetes care 1992;15(12):1892-901.
1992: David E Kelley; M Mokan; Lawrence J. Manderino
Intracellular defects in glucose metabolism in obese patients with NIDDM.
Diabetes 1992;41(6):698-706.
1992: agostino consoli; N Nurjahan; J E Gerich; Lawrence J. Manderino
Skeletal muscle is a major site of lactate uptake and release during hyperinsulinemia.
Metabolism: clinical and experimental 1992;41(2):176-9.
1990: David E Kelley; Lawrence J. Manderino
Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus.
The Journal of clinical investigation 1990;86(6):1999-2007.
1990: Lawrence J. Manderino; agostino consoli; David E Kelley; J J Reilly; N Nurjhan
Fasting hyperglycemia normalizes oxidative and nonoxidative pathways of insulin-stimulated glucose metabolism in noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1990;71(6):1544-51.
1990: David E Kelley; J P Reilly; Thiemo F Veneman; Lawrence J. Manderino
Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans.
The American journal of physiology 1990;258(6 Pt 1):E923-9.
1990: J E Gerich; Asimina Mitrakou; D Kelley; Lawrence J. Manderino; N Nurjhan; J Reilly; Trond Jenssen; Thiemo F Veneman; agostino consoli
Contribution of impaired muscle glucose clearance to reduced postabsorptive systemic glucose clearance in NIDDM.
Diabetes 1990;39(2):211-6.
1989: Lawrence J. Manderino
Regulation of skeletal muscle pyruvate dehydrogenase and glycogen synthase in man.
Diabetes/metabolism reviews 1989;5(6):475-86.
1988: K S Wright; H Beck-Nielsen; O G Kolterman; Lawrence J. Manderino
Decreased activation of skeletal muscle glycogen synthase by mixed-meal ingestion in NIDDM.
Diabetes 1988;37(4):436-40.
1988: Peter J Campbell; Lawrence J. Manderino; J E Gerich
Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental 1988;37(1):15-21.
1987: Zecharia Madar; J M Bell; Lawrence J. Manderino
Glycogen synthase kinetics in isolated human adipocytes: an in vitro model for the effects of insulin on glycogen synthase.
Biochemical medicine and metabolic biology 1987;38(3):265-71.
1987: Lawrence J. Manderino; K S Wright; L S Verity; J Nichols; J M Bell; O G Kolterman; H Beck-Nielsen
Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism.
The Journal of clinical investigation 1987;80(3):655-63.
1986: Lawrence J. Manderino; Zecharia Madar; O G Kolterman; J M Bell; Jerrold M Olefsky
Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects.
The American journal of physiology 1986;251(4 Pt 1):E489-96.
1986: W F Schwenk; Robert A Rizza; Lawrence J. Manderino; J E Gerich; A B Hayles; M W Haymond
Familial insulin resistance and acanthosis nigricans. Presence of a postbinding defect.
Diabetes 1986;35(1):33-7.
1985: A D Baron; O G Kolterman; J Bell; Lawrence J. Manderino; Jerrold M Olefsky
Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects.
The Journal of clinical investigation 1985;76(5):1782-8.
1985: G Dimitriadis; B Baker; Harold Michael Marsh; Lawrence J. Manderino; Robert A Rizza; R Bergman; M Haymond; John E Gerich
Effect of thyroid hormone excess on action, secretion, and metabolism of insulin in humans.
The American journal of physiology 1985;248(5 Pt 1):E593-601.
1985: Robert A Rizza; Lawrence J. Manderino; J Genest; B A Baker; J E Gerich
Production of insulin resistance by hyperinsulinaemia in man.
Diabetologia 1985;28(2):70-5.
1984: Lawrence J. Manderino; Peter J Campbell; I S Gottesman; J E Gerich
Abnormal coupling of insulin receptor binding in noninsulin-dependent diabetes.
The American journal of physiology 1984;247(5 Pt 1):E688-92.
1984: Lawrence J. Manderino; E Tsalikian; S Bartold; Harold Michael Marsh; A Carney; E Buerklin; G Tutwiler; M Haymond; B Handwerger; Robert A Rizza
Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies.
The Journal of clinical endocrinology and metabolism 1984;59(4):658-64.
1984: Lawrence J. Manderino; B Baker; Robert A Rizza; J Genest; John E Gerich
Infusion of insulin impairs human adipocyte glucose metabolism in vitro without decreasing adipocyte insulin receptor binding.
Diabetologia 1984;27(3):358-63.
1984: Lawrence J. Manderino; J E Gerich
Prolonged sulfonylurea administration decreases insulin resistance and increases insulin secretion in non-insulin-dependent diabetes mellitus: evidence for improved insulin action at a postreceptor site in hepatic as well as extrahepatic tissues.
Diabetes care 1984;7 Suppl 1():89-99.
1984: B Baker; Lawrence J. Manderino; B Brick; Robert A Rizza; John E Gerich
Influence of changes in insulin receptor binding during insulin infusions on the shape of the insulin dose-response curve for glucose disposal in man.
The Journal of clinical endocrinology and metabolism 1984;58(2):392-6.
1984: I Gottesman; Lawrence J. Manderino; John E Gerich
Use of glucose uptake and glucose clearance for the evaluation of insulin action in vivo.
Diabetes 1984;33(2):184-91.
1984: Lawrence J. Manderino
Insulin and glucagon binding to isolated hepatocytes of Egyptian sand rats (Psammomys obesus): evidence for an insulin receptor defect.
Comparative biochemistry and physiology. A, Comparative physiology 1984;78(3):519-23.
1983: I Gottesman; Lawrence J. Manderino; John E Gerich
Estimation and kinetic analysis of insulin-independent glucose uptake in human subjects.
The American journal of physiology 1983;244(6):E632-5.
1982: I Gottesman; Lawrence J. Manderino; C Verdonk; Robert A Rizza; John E Gerich
Insulin increases the maximum velocity for glucose uptake without altering the Michaelis constant in man. Evidence that insulin increases glucose uptake merely by providing additional transport sites.
The Journal of clinical investigation 1982;70(6):1310-4.
1982: Robert A Rizza; Lawrence J. Manderino; J E Gerich
Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization.
Diabetes 1982;31(8 Pt 1):663-9.
1982: Robert A Rizza; Lawrence J. Manderino; J E Gerich
Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action.
The Journal of clinical endocrinology and metabolism 1982;54(1):131-8.
1982: I S Gottesman; Lawrence J. Manderino; J E Gerich
Somatostatin: its role in health and disease.
Special topics in endocrinology and metabolism 1982;4():177-243.
1981: Robert A Rizza; Lawrence J. Manderino; J E Gerich
Mechanism and significance of insulin resistance in non-insulin-dependent diabetes mellitus.
Diabetes 1981;30(12):990-5.
1981: Robert A Rizza; Lawrence J. Manderino; J E Gerich
Dose-response characteristics for effects of insulin on production and utilization of glucose in man.
The American journal of physiology 1981;240(6):E630-9.
1981: Lawrence J. Manderino; D Stenner; W Blanchard; S Nissen; J Gerich; N Ling; P Brazeau; P Bohlen; F Esch; Roger Guillemin
Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion.
Nature 1981;291(5810):76-7.
1981: Robert A Rizza; M W Haymond; C A Verdonk; Lawrence J. Manderino; J M Miles; F J Service; J E Gerich
Pathogenesis of hypoglycemia in insulinoma patients: suppression of hepatic glucose production by insulin.
Diabetes 1981;30(5):377-81.
1981: Robert A Rizza; Lawrence J. Manderino; J E Gerich
Mechanisms of insulin resistance in man. Assessment using the insulin dose-response curve in conjunction with insulin-receptor binding.
The American journal of medicine 1981;70(1):169-76.
1980: M Itoh; Lawrence J. Manderino; J E Gerich
Antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro: evidence for a physiologic role for endogenous somatostatin in the regulation of pancreatic A- and B-cell function.
Diabetes 1980;29(9):693-6.
1980: Lawrence J. Manderino; M Itoh; W Blanchard; G Patton; J Gerich
Stimulation of insulin release in the absence of extracellular calcium by isobutylmethylxanthine and its inhibition by somatostatin.
Endocrinology 1980;106(2):430-3.
1974: Lawrence J. Manderino; J D Cadien
Letter: Use of ranked migration estimates for detecting natural selection.
American journal of human genetics 1974;26(1):108-12.