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Alex Roher

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Roher Alex E; Maarouf Chera L; Sue Lucia I; Hu Yiran; Wilson Jeffrey; Beach Thomas G
Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease.
Kokjohn Tyler A; Roher Alex E
Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions.
Kokjohn Tyler A; Roher Alex E
Antibody responses, amyloid-beta peptide remnants and clinical effects of AN-1792 immunization in patients with AD in an interrupted trial.

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All Publications

2009: Roher Alex E; Maarouf Chera L; Sue Lucia I; Hu Yiran; Wilson Jeffrey; Beach Thomas G
Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2009;14(7):493-501.
2009: Kokjohn Tyler A; Roher Alex E
Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(4):340-7.
2009: Kokjohn Tyler A; Roher Alex E
Antibody responses, amyloid-beta peptide remnants and clinical effects of AN-1792 immunization in patients with AD in an interrupted trial.
CNS & neurological disorders drug targets 2009;8(2):88-97.
2009: Roher Alex E; Esh Chera L; Kokjohn Tyler A; Castaño Eduardo M; Van Vickle Gregory D; Kalback Walter M; Patton R Lyle; Luehrs Dean C; Daugs Ian D; Kuo Yu-Min; Emmerling Mark R; Soares Holly; Quinn Joseph F; Kaye Jeffrey; Connor Donald J; Silverberg Nina B; Adler Charles H; Seward James D; Beach Thomas G; Sabbagh Marwan N
Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(1):18-29.
2008: Beach Thomas G; Sue Lucia I; Walker Douglas G; Roher Alex E; Lue LihFen; Vedders Linda; Connor Donald J; Sabbagh Marwan N; Rogers Joseph
The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007.
Cell and tissue banking 2008;9(3):229-45.
2008: Van Vickle Gregory D; Esh Chera L; Daugs Ian D; Kokjohn Tyler A; Kalback Walter M; Patton R Lyle; Luehrs Dean C; Walker Douglas G; Lue Lih-Fen; Beach Thomas G; Davis Judianne; Van Nostrand William E; Castaño Eduardo M; Roher Alex E
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
The American journal of pathology 2008;173(2):483-93.
2008: Llovera Ramiro E; de Tullio Matías; Alonso Leonardo G; Leissring Malcolm A; Kaufman Sergio B; Roher Alex E; de Prat Gay Gonzalo; Morelli Laura; Castaño Eduardo M
The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis.
The Journal of biological chemistry 2008;283(25):17039-48.
2008: Van Vickle Gregory D; Esh Chera L; Kokjohn Tyler A; Patton R Lyle; Kalback Walter M; Luehrs Dean C; Beach Thomas G; Newel Amanda J; Lopera Francisco; Ghetti Bernardino; Vidal Ruben; Castaño Eduardo M; Roher Alex E
Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease.
Molecular medicine (Cambridge, Mass.) 2008;14(3-4):184-94.
2008: Maarouf Chera L; Daugs Ian D; Spina Salvatore; Vidal Ruben; Kokjohn Tyler A; Patton R Lyle; Kalback Walter M; Luehrs Dean C; Walker Douglas G; Castaño Eduardo M; Beach Thomas G; Ghetti Bernardino; Roher Alex E
Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations.
Molecular neurodegeneration 2008;3():20.
2007: Van Vickle Gregory D; Esh Chera L; Kalback Walter M; Patton R Lyle; Luehrs Dean C; Kokjohn Tyler A; Fifield Frederick G; Fraser Paul E; Westaway David; McLaurin Joanne; Lopez John; Brune Daniel; Newel Amanda J; Poston Marissa; Beach Thomas G; Roher Alex E
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Biochemistry 2007;46(36):10317-27.
2007: Beach Thomas G; Wilson Jeffrey R; Sue Lucia I; Newell Amanda; Poston Marissa; Cisneros Raquel; Pandya Yoga; Esh Chera; Connor Donald J; Sabbagh Marwan; Walker Douglas G; Roher Alex E
Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles.
Acta neuropathologica 2007;113(1):13-21.
2006: Dudkin K N; Chueva I V; Makarov F N; Bich T G; Roher A E
Disorders of learning and memory processes in a monkey model of Alzheimer's disease: the role of the associative area of the cerebral cortex.
Neuroscience and behavioral physiology 2006;36(8):789-99.
2006: Roher Alex E; Garami Zsolt; Alexandrov Andrei V; Kokjohn Tyler A; Esh Chera L; Kalback Walter M; Vedders Linda J; Wilson Jeffrey R; Sabbagh Marwan N; Beach Thomas G
Interaction of cardiovascular disease and neurodegeneration: transcranial Doppler ultrasonography and Alzheimer's disease.
Neurological research 2006;28(6):672-8.
2006: Patton R Lyle; Kalback Walter M; Esh Chera L; Kokjohn Tyler A; Van Vickle Gregory D; Luehrs Dean C; Kuo Yu-Min; Lopez John; Brune Daniel; Ferrer Isidro; Masliah Eliezer; Newel Amanda J; Beach Thomas G; Castaño Eduardo M; Roher Alex E
Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis.
The American journal of pathology 2006;169(3):1048-63.
2006: Castaño Eduardo M; Roher Alex E; Esh Chera L; Kokjohn Tyler A; Beach Thomas
Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects.
Neurological research 2006;28(2):155-63.
2006: Roher Alex E; Kokjohn Tyler A; Beach Thomas G
An association with great implications: vascular pathology and Alzheimer disease.
Alzheimer disease and associated disorders 2006;20(1):73-5.
2005: Watson Desiree; Castaño Eduardo; Kokjohn Tyler A; Kuo Yu-Min; Lyubchenko Yuri; Pinsky David; Connolly E Sander; Esh Chera; Luehrs Dean C; Stine W Blaine; Rowse Linda M; Emmerling Mark R; Roher Alex E
Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.
Neurological research 2005;27(8):869-81.
2005: Esh Chera; Patton Lyle; Kalback Walter; Kokjohn Tyler A; Lopez John; Brune Daniel; Newell Amanda J; Beach Thomas; Schenk Dale; Games Dora; Paul Steven; Bales Kelly; Ghetti Bernardino; Castaño Eduardo M; Roher Alex E
Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides.
Biochemistry 2005;44(42):13807-19.
2005: Roher A E; Esh C; Kokjohn T; Sue L; Beach T
Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center.
Neurology 2005;65(6):974; author reply 974.
2005: Dudkin K N; Chueva I V; Makarov F N; Bich T G; Roher A E
[Disorders in learning and memory processes in the monkey model of Alzheimer's disease: the role of the cerebral cortex associative areas]
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk 2005;91(8):857-71.
2005: Miravalle Leticia; Calero Miguel; Takao Masaki; Roher Alex E; Ghetti Bernardino; Vidal Ruben
Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques.
Biochemistry 2005;44(32):10810-21.
2005: Chaney Michael O; Stine W Blaine; Kokjohn Tyler A; Kuo Yu-Min; Esh Chera; Rahman Afroza; Luehrs Dean C; Schmidt Ann Marie; Stern David; Yan Shi Du; Roher Alex E
RAGE and amyloid beta interactions: atomic force microscopy and molecular modeling.
Biochimica et biophysica acta 2005;1741(1-2):199-205.
2004: Roher Alex E; Esh Chera; Rahman Afroza; Kokjohn Tyler A; Beach Thomas G
Atherosclerosis of cerebral arteries in Alzheimer disease.
Stroke; a journal of cerebral circulation 2004;35(11 Suppl 1):2623-7.
2004: Arancio Ottavio; Zhang Hui Ping; Chen Xi; Lin Chang; Trinchese Fabrizio; Puzzo Daniela; Liu Shumin; Hegde Ashok; Yan Shi Fang; Stern Alan; Luddy John S; Lue Lih-Fen; Walker Douglas G; Roher Alex; Buttini Manuel; Mucke Lennart; Li Weiying; Schmidt Ann Marie; Kindy Mark; Hyslop Paul A; Stern David M; Du Yan Shirley Shi
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
The EMBO journal 2004;23(20):4096-105.
2004: Kalback Walter; Esh Chera; Castaño Eduardo M; Rahman Afroza; Kokjohn Tyler; Luehrs Dean C; Sue Lucia; Cisneros Raquel; Gerber Francoise; Richardson Claudia; Bohrmann Bernd; Walker Douglas G; Beach Thomas G; Roher Alex E
Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease.
Neurological research 2004;26(5):525-39.
2004: Roher Alex E; Kokjohn Tyler A; Esh Chera; Weiss Nicole; Childress Jennifer; Kalback Walter; Luehrs Dean C; Lopez John; Brune Daniel; Kuo Yu-Min; Farlow Martin; Murrell Jill; Vidal Ruben; Ghetti Bernardino
The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.
The Journal of biological chemistry 2004;279(7):5829-36.
2003: Roher Alex E; Esh Chera; Kokjohn Tyler A; Kalback Walter; Luehrs Dean C; Seward James D; Sue Lucia I; Beach Thomas G
Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):2055-62.
2003: Chaney Michael O; Baudry Jerome; Esh Chera; Childress Jennifer; Luehrs Dean C; Kokjohn Tyler A; Roher Alex E
A beta, aging, and Alzheimer's disease: a tale, models, and hypotheses.
Neurological research 2003;25(6):581-9.
2003: Roher Alex E; Kuo Yu-Min; Esh Chera; Knebel Carmen; Weiss Nicole; Kalback Walter; Luehrs Dean C; Childress Jennifer L; Beach Thomas G; Weller Roy O; Kokjohn Tyler A
Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease.
Molecular medicine (Cambridge, Mass.) 2003;9(3-4):112-22.
2003: Dudkin K N; Chueva I V; Makarov F N; Beach T G; Roher A E
Alterations of the sensory and cognitive components of operative memory in a monkey model of Alzheimer's disease.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian 2003;389():99-101.
2002: Roher Alex E; Kokjohn Tyler A
Of mice and men: The relevance of transgenic mice Abeta immunizations to Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2002;4(5):431-4.
2002: Opazo Carlos; Huang Xudong; Cherny Robert A; Moir Robert D; Roher Alex E; White Anthony R; Cappai Roberto; Masters Colin L; Tanzi Rudolph E; Inestrosa Nibaldo C; Bush Ashley I
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
The Journal of biological chemistry 2002;277(43):40302-8.
2002: Roher Alex E; Weiss Nicole; Kokjohn Tyler A; Kuo Yu-Min; Kalback Walter; Anthony Jacqueline; Watson Desiree; Luehrs Dean C; Sue Lucia; Walker Douglas; Emmerling Mark; Goux Warren; Beach Thomas
Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease.
Biochemistry 2002;41(37):11080-90.
2002: Walker Lary C; Callahan Michael J; Bian Feng; Durham Robert A; Roher Alex E; Lipinski William J
Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice.
Peptides 2002;23(7):1241-7.
2002: Dudkin K N; Chueva I V; Makarov F N; Beach T G; Roher A
Impaired processes of working memory in the monkey model of Alzheimer's disease.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian 2002;383():106-8.
2002: Kalback Walter; Watson M Desiree; Kokjohn Tyler A; Kuo Yu-Min; Weiss Nicole; Luehrs Dean C; Lopez John; Brune Daniel; Sisodia Sangram S; Staufenbiel Matthias; Emmerling Mark; Roher Alex E
APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
Biochemistry 2002;41(3):922-8.
2001: Kuo Y M; Beach T G; Sue L I; Scott S; Layne K J; Kokjohn T A; Kalback W M; Luehrs D C; Vishnivetskaya T A; Abramowski D; Sturchler-Pierrat C; Staufenbiel M; Weller R O; Roher A E
The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease.
Molecular medicine (Cambridge, Mass.) 2001;7(9):609-18.
2001: Beach T G; Kuo Y M; Schwab C; Walker D G; Roher A E
Reduction of cortical amyloid beta levels in guinea pig brain after systemic administration of physostigmine.
Neuroscience letters 2001;310(1):21-4.
2001: Shen Y; Lue L; Yang L; Roher A; Kuo Y; Strohmeyer R; Goux W J; Lee V; Johnson G V; Webster S D; Cooper N R; Bradt B; Rogers J
Complement activation by neurofibrillary tangles in Alzheimer's disease.
Neuroscience letters 2001;305(3):165-8.
2001: Kuo Y M; Kokjohn T A; Beach T G; Sue L I; Brune D; Lopez J C; Kalback W M; Abramowski D; Sturchler-Pierrat C; Staufenbiel M; Roher A E
Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains.
The Journal of biological chemistry 2001;276(16):12991-8.
2000: Munson G W; Roher A E; Kuo Y M; Gilligan S M; Reardon C A; Getz G S; LaDu M J
SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptides.
Biochemistry 2000;39(51):16119-24.
2000: Yan S D; Roher A; Chaney M; Zlokovic B; Schmidt A M; Stern D
Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide.
Biochimica et biophysica acta 2000;1502(1):145-57.
2000: Roher A E; Baudry J; Chaney M O; Kuo Y M; Stine W B; Emmerling M R
Oligomerizaiton and fibril asssembly of the amyloid-beta protein.
Biochimica et biophysica acta 2000;1502(1):31-43.
2000: Atwood C S; Huang X; Khatri A; Scarpa R C; Kim Y S; Moir R D; Tanzi R E; Roher A E; Bush A I
Copper catalyzed oxidation of Alzheimer Abeta.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):777-83.
2000: Yan S D; Zhu H; Zhu A; Golabek A; Du H; Roher A; Yu J; Soto C; Schmidt A M; Stern D; Kindy M
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
Nature medicine 2000;6(6):643-51.
2000: Kuo Y M; Crawford F; Mullan M; Kokjohn T A; Emmerling M R; Weller R O; Roher A E
Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease.
Molecular medicine (Cambridge, Mass.) 2000;6(5):430-9.
2000: Kane M D; Lipinski W J; Callahan M J; Bian F; Durham R A; Schwarz R D; Roher A E; Walker L C
Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(10):3606-11.
2000: Roher A E; Kuo Y M; Potter P E; Emmerling M R; Durham R A; Walker D G; Sue L I; Honer W G; Beach T G
Cortical cholinergic denervation elicits vascular A beta deposition.
Annals of the New York Academy of Sciences 2000;903():366-73.
2000: Sparks D L; Kuo Y M; Roher A; Martin T; Lukas R J
Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations.
Annals of the New York Academy of Sciences 2000;903():335-44.
2000: Emmerling M R; Morganti-Kossmann M C; Kossmann T; Stahel P F; Watson M D; Evans L M; Mehta P D; Spiegel K; Kuo Y M; Roher A E; Raby C A
Traumatic brain injury elevates the Alzheimer's amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury.
Annals of the New York Academy of Sciences 2000;903():118-22.
2000: Weller R O; Massey A; Kuo Y M; Roher A E
Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;903():110-7.
2000: Beach T G; Kuo Y M; Spiegel K; Emmerling M R; Sue L I; Kokjohn K; Roher A E
The cholinergic deficit coincides with Abeta deposition at the earliest histopathologic stages of Alzheimer disease.
Journal of neuropathology and experimental neurology 2000;59(4):308-13.
2000: Beach T G; Potter P E; Kuo Y M; Emmerling M R; Durham R A; Webster S D; Walker D G; Sue L I; Scott S; Layne K J; Roher A E
Cholinergic deafferentation of the rabbit cortex: a new animal model of Abeta deposition.
Neuroscience letters 2000;283(1):9-12.
2000: Kuo Y M; Kokjohn T A; Watson M D; Woods A S; Cotter R J; Sue L I; Kalback W M; Emmerling M R; Beach T G; Roher A E
Elevated abeta42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AbetaPP metabolism.
The American journal of pathology 2000;156(3):797-805.
2000: Kuo Y M; Kokjohn T A; Kalback W; Luehrs D; Galasko D R; Chevallier N; Koo E H; Emmerling M R; Roher A E
Amyloid-beta peptides interact with plasma proteins and erythrocytes: implications for their quantitation in plasma.
Biochemical and biophysical research communications 2000;268(3):750-6.
1999: Yan S D; Roher A; Schmidt A M; Stern D M
Cellular cofactors for amyloid beta-peptide-induced cell stress. Moving from cell culture to in vivo.
The American journal of pathology 1999;155(5):1403-11.
1999: Lue L F; Kuo Y M; Roher A E; Brachova L; Shen Y; Sue L; Beach T; Kurth J H; Rydel R E; Rogers J
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease.
The American journal of pathology 1999;155(3):853-62.
1999: Roher A E; Kuo Y M; Kokjohn K M; Emmerling M R; Gracon S
Amyloid and lipids in the pathology of Alzheimer disease.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1999;6(2):136-45.
1999: Kuo Y M; Emmerling M R; Lampert H C; Hempelman S R; Kokjohn T A; Woods A S; Cotter R J; Roher A E
High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease.
Biochemical and biophysical research communications 1999;257(3):787-91.
1999: Yan S D; Shi Y; Zhu A; Fu J; Zhu H; Zhu Y; Gibson L; Stern E; Collison K; Al-Mohanna F; Ogawa S; Roher A; Clarke S G; Stern D M
Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity.
The Journal of biological chemistry 1999;274(4):2145-56.
1999: Lowenson J D; Clarke S; Roher A E
Chemical modifications of deposited amyloid-beta peptides.
Methods in enzymology 1999;309():89-105.
1999: Roher A E; Kuo Y M
Isolation of amyloid deposits from brain.
Methods in enzymology 1999;309():58-67.
1998: Raby C A; Morganti-Kossmann M C; Kossmann T; Stahel P F; Watson M D; Evans L M; Mehta P D; Spiegel K; Kuo Y M; Roher A E; Emmerling M R
Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid.
Journal of neurochemistry 1998;71(6):2505-9.
1998: Kuo Y M; Emmerling M R; Bisgaier C L; Essenburg A D; Lampert H C; Drumm D; Roher A E
Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.
Biochemical and biophysical research communications 1998;252(3):711-5.
1998: Giulian D; Haverkamp L J; Yu J; Karshin W; Tom D; Li J; Kazanskaia A; Kirkpatrick J; Roher A E
The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.
The Journal of biological chemistry 1998;273(45):29719-26.
1998: Chaney M O; Webster S D; Kuo Y M; Roher A E
Molecular modeling of the Abeta1-42 peptide from Alzheimer's disease.
Protein engineering 1998;11(9):761-7.
1998: Weller R O; Massey A; Newman T A; Hutchings M; Kuo Y M; Roher A E
Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease.
The American journal of pathology 1998;153(3):725-33.
1998: Fiala M; Zhang L; Gan X; Sherry B; Taub D; Graves M C; Hama S; Way D; Weinand M; Witte M; Lorton D; Kuo Y M; Roher A E
Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model.
Molecular medicine (Cambridge, Mass.) 1998;4(7):480-9.
1998: Yan S D; Stern D; Kane M D; Kuo Y M; Lampert H C; Roher A E
RAGE-Abeta interactions in the pathophysiology of Alzheimer's disease.
Restorative neurology and neuroscience 1998;12(2-3):167-73.
1998: Kuo Y M; Webster S; Emmerling M R; De Lima N; Roher A E
Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease.
Biochimica et biophysica acta 1998;1406(3):291-8.
1997: Yan S D; Fu J; Soto C; Chen X; Zhu H; Al-Mohanna F; Collison K; Zhu A; Stern E; Saido T; Tohyama M; Ogawa S; Roher A; Stern D
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
Nature 1997;389(6652):689-95.
1997: Kuo Y M; Emmerling M R; Woods A S; Cotter R J; Roher A E
Isolation, chemical characterization, and quantitation of A beta 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits.
Biochemical and biophysical research communications 1997;237(1):188-91.
1997: Du Yan S; Zhu H; Fu J; Yan S F; Roher A; Tourtellotte W W; Rajavashisth T; Chen X; Godman G C; Stern D; Schmidt A M
Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5296-301.
1996: Giulian D; Haverkamp L J; Yu J H; Karshin W; Tom D; Li J; Kirkpatrick J; Kuo L M; Roher A E
Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(19):6021-37.
1996: Yan S D; Chen X; Fu J; Chen M; Zhu H; Roher A; Slattery T; Zhao L; Nagashima M; Morser J; Migheli A; Nawroth P; Stern D; Schmidt A M
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.
Nature 1996;382(6593):685-91.
1996: Roher A E; Chaney M O; Kuo Y M; Webster S D; Stine W B; Haverkamp L J; Woods A S; Cotter R J; Tuohy J M; Krafft G A; Bonnell B S; Emmerling M R
Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.
The Journal of biological chemistry 1996;271(34):20631-5.
1996: Bagchi M; Roher A E; Bannerjee A; Barrett R; Hazlett L D; Kasunic T; Maisel H
Identification of a ubiquitin-like protein in the mammalian vitreous humor.
Journal of cellular biochemistry 1996;61(1):26-30.
1996: Kuo Y M; Emmerling M R; Vigo-Pelfrey C; Kasunic T C; Kirkpatrick J B; Murdoch G H; Ball M J; Roher A E
Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.
The Journal of biological chemistry 1996;271(8):4077-81.
1995: Grammas P; Moore P; Botchlet T; Hanson-Painton O; Cooper D R; Ball M J; Roher A
Cerebral microvessels in Alzheimer's have reduced protein kinase C activity.
Neurobiology of aging 1995;16(4):563-9.
1995: Grammas P; Botchlet T; Fugate R; Ball M J; Roher A E
Alzheimer disease amyloid proteins inhibit brain endothelial cell proliferation in vitro.
Dementia (Basel, Switzerland) 1995;6(3):126-30.
1994: Roher A E; Kasunic T C; Woods A S; Cotter R J; Ball M J; Fridman R
Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A.
Biochemical and biophysical research communications 1994;205(3):1755-61.
1994: Stojanovic A; Roher A E; Ball M J
Quantitative analysis of lipofuscin and neurofibrillary tangles in the hippocampal neurons of Alzheimer disease brains.
Dementia (Basel, Switzerland) 1994;5(5):229-33.
1994: Gowing E; Roher A E; Woods A S; Cotter R J; Chaney M; Little S P; Ball M J
Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease.
The Journal of biological chemistry 1994;269(15):10987-90.
1994: Grammas P; Roher A E; Ball M J
Increased accumulation of cAMP in cerebral microvessels in Alzheimer's disease.
Neurobiology of aging 1994;15(1):113-6.
1993: Roher A E; Lowenson J D; Clarke S; Woods A S; Cotter R J; Gowing E; Ball M J
beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10836-40.
1993: Roher A E; Palmer K C; Yurewicz E C; Ball M J; Greenberg B D
Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue.
Journal of neurochemistry 1993;61(5):1916-26.
1993: Roher A E; Lowenson J D; Clarke S; Wolkow C; Wang R; Cotter R J; Reardon I M; Zürcher-Neely H A; Heinrikson R L; Ball M J
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.
The Journal of biological chemistry 1993;268(5):3072-83.
1991: Roher A E; Palmer K C; Capodilupo J; Wakade A R; Ball M J
New biochemical insights to unravel the pathogenesis of Alzheimer's lesions.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1991;18(3 Suppl):408-10.
1991: Roher A E; Ball M J; Bhave S V; Wakade A R
Beta-amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons.
Biochemical and biophysical research communications 1991;174(2):572-9.
1988: Roher A E; Palmer K C; Chau V; Ball M J
Isolation and chemical characterization of Alzheimer's disease paired helical filament cytoskeletons: differentiation from amyloid plaque core protein.
The Journal of cell biology 1988;107(6 Pt 2):2703-16.
1988: Roher A; Gray E G; Paula-Barbosa M
Alzheimer's disease: coated vesicles, coated pits and the amyloid-related cell.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1988;232(1269):367-73.
1987: Palutke M; KuKuruga D; Wolfe D; Roher A
Flow cytometric purification of Alzheimer's disease amyloid plaque core protein using thioflavin T.
Cytometry 1987;8(5):494-9.
1987: Gray E G; Paula-Barbosa M; Roher A
Alzheimer's disease: paired helical filaments and cytomembranes.
Neuropathology and applied neurobiology 1987;13(2):91-110.
1986: Roher A; Wolfe D; Palutke M; KuKuruga D
Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2662-6.
1986: Roher A; Lieska N; Spitz W
The amino acid sequence of human cardiac troponin-C.
Muscle & nerve 1986;9(1):73-7.
1985: Berk R S; Moon M; Higbee R; Cramer C; Roher A; Weis M; Hazlett L
Actinlike material in Pseudomonas aeruginosa.
Infection and immunity 1985;50(2):483-7.

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