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Eric Sobie

Research Profile

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Publications

TOP 3
Eva Poláková; Eric Sobie
Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses.
Young-Seon Lee; Ona Z Liu; Eric Sobie
Decoding myocardial Ca(2+) signals across multiple spatial scales: A role for sensitivity analysis.
Young-Seon Lee; Ona Z Liu; Hyun Seok Hwang; Bjorn C Knollmann; Eric Sobie
Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.

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All Publications

2013: Eva Poláková; Eric Sobie
Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses.
Cardiovascular research 2013;98(2):233-9.
2013: Young-Seon Lee; Ona Z Liu; Eric Sobie
Decoding myocardial Ca(2+) signals across multiple spatial scales: A role for sensitivity analysis.
Journal of molecular and cellular cardiology 2013;58():92-9.
2013: Young-Seon Lee; Ona Z Liu; Hyun Seok Hwang; Bjorn C Knollmann; Eric Sobie
Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.
Biophysical journal 2013;104(5):1142-50.
2012: Thomas J LaRocca; Daniel Benhayon; Jiqiu Chen; Joseph Y Cheung; Frank Fabris; Roger J Hajjar; LaTronya McCollum; Alison D Schecter; Eric Sobie; Shihong Zhang; Djamel Lebeche
Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway.
American journal of physiology. Heart and circulatory physiology 2012;303(3):H353-67.
2012: Amrita X Sarkar; David J Christini; Eric Sobie
Exploiting mathematical models to illuminate electrophysiological variability between individuals.
The Journal of physiology 2012;590(Pt 11):2555-67.
2012: Eric Sobie; William Lederer
Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.
Journal of molecular and cellular cardiology 2012;52(2):304-11.
2011: Amrita X Sarkar; Eric Sobie
Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(11):1749-55.
2011: Eric Sobie
Computational modeling of the cell cycle.
Science signaling 2011;4(192):tr11.
2011: Eric Sobie
Bistability in biochemical signaling models.
Science signaling 2011;4(192):tr10.
2011: George S B Williams; Aristide C Chikando; William Lederer; Eric Sobie; Hoang-Trong M Tuan; M Saleet Jafri
Dynamics of calcium sparks and calcium leak in the heart.
Biophysical journal 2011;101(6):1287-96.
2011: Eric Sobie
An introduction to MATLAB.
Science signaling 2011;4(191):tr7.
2011: Eric Sobie
An introduction to dynamical systems.
Science signaling 2011;4(191):tr6.
2011: Eric Sobie; Sherry L Jenkins; Young-Seon Lee; Ravi Iyengar
Systems biology--biomedical modeling.
Science signaling 2011;4(190):tr2.
2011: Hena R Ramay; Ona Z Liu; Eric Sobie
Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity.
Cardiovascular research 2011;91(4):598-605.
2011: Perundurai S Dhandapany; Frank Fabris; Rahul Tonk; Ardo Illaste; Ioannis Karakikes; Mehran Sorourian; Jipo Sheng; Roger J Hajjar; Marco Tartaglia; Eric Sobie; Djamel Lebeche; Bruce D Gelb
Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes.
Journal of molecular and cellular cardiology 2011;51(1):4-15.
2011: Young-Seon Lee; Wen Dun; Penelope A Boyden; Eric Sobie
Complex and rate-dependent beat-to-beat variations in Ca2+ transients of canine Purkinje cells.
Journal of molecular and cellular cardiology 2011;50(4):662-9.
2011: Hoang-Trong Minh Tuan; George S B Williams; Aristide C Chikando; W Jonathan Lederer; Eric Sobie; M Saleet Jafri
Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2011;2011():4677-80.
2011: Eric Sobie; Amrita X Sarkar
Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2011;2011():4657-60.
2010: Jana M Hartman; Eric Sobie; Gregory D Smith
Spontaneous Ca2+ sparks and Ca2+ homeostasis in a minimal model of permeabilized ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2010;299(6):H1996-2008.
2010: Eric Sobie; S L Jenkins; Ravi Iyengar; T A Krulwich
Training in systems pharmacology: predoctoral program in pharmacology and systems biology at Mount Sinai School of Medicine.
Clinical pharmacology and therapeutics 2010;88(1):19-22.
2010: Hena R Ramay; M Saleet Jafri; William Lederer; Eric Sobie
Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes.
Biophysical journal 2010;98(11):2515-23.
2010: Amrita X Sarkar; Eric Sobie
Regression analysis for constraining free parameters in electrophysiological models of cardiac cells.
PLoS computational biology 2010;6(9):e1000914.
2009: Eric Sobie; Hena R Ramay
Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model.
The Journal of physiology 2009;587(Pt 6):1293-9.
2009: Eric Sobie
Parameter sensitivity analysis in electrophysiological models using multivariable regression.
Biophysical journal 2009;96(4):1264-74.
2008: John H B Bridge; Natalia S Torres; Eric Sobie
New insights into the structure and function of couplons.
The Journal of physiology 2008;586(16):3735.
2008: George S B Williams; Marco A Huertas; Eric Sobie; M Saleet Jafri; Gregory D Smith
Moment closure for local control models of calcium-induced calcium release in cardiac myocytes.
Biophysical journal 2008;95(4):1689-703.
2008: Rachele Lipsky; Essie M Potts; Sima T Tarzami; Akil A Puckerin; Joanne Stocks; Alison D Schecter; Eric Sobie; Fadi G Akar; María A Diversé-Pierluissi
beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway.
The Journal of biological chemistry 2008;283(25):17221-6.
2008: Linda J Wang; Eric Sobie
Mathematical model of the neonatal mouse ventricular action potential.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2565-75.
2008: Eric Sobie; Mark Cannell; John H B Bridge
Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes.
Biophysical journal 2008;94(7):L54-6.
2008: Ravi Iyengar; Maria A Diverse-Pierluissi; Sherry L Jenkins; Andrew M Chan; Lakshmi A Devi; Eric Sobie; Adrian T Ting; Daniel C Weinstein
Inquiry learning. Integrating content detail and critical reasoning by peer review.
Science (New York, N.Y.) 2008;319(5867):1189-90.
2008: Sherry L Jenkins; Ravi Iyengar; Maria A Diverse-Pierluissi; Andrew M Chan; Lakshmi A Devi; Eric Sobie; Adrian T Ting; Daniel C Weinstein
Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment.
Science signaling 2008;1(9):tr2.
2007: Eric Sobie; Joseph Kao; William Lederer
Novel approach to real-time flash photolysis and confocal [Ca2+] imaging.
Pflügers Archiv : European journal of physiology 2007;454(4):663-73.
2007: Jiahong Ni; Darryl A Auston; David A Freilich; Sukumaran Muralidharan; Eric Sobie; Joseph Kao
Photochemical gating of intracellular Ca2+ release channels.
Journal of the American Chemical Society 2007;129(17):5316-7.
2007: George S B Williams; Marco A Huertas; Eric Sobie; M Saleet Jafri; Gregory D Smith
A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes.
Biophysical journal 2007;92(7):2311-28.
2007: Leon Collis; Marian B Meyers; Jie Zhang; Colin Phoon; Eric Sobie; William A Coetzee; Glenn I Fishman
Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(2):475-87.
2006: Eric Sobie; Long-Sheng Song; William Lederer
Restitution of Ca(2+) release and vulnerability to arrhythmias.
Journal of cardiovascular electrophysiology 2006;17 Suppl 1():S64-S70.
2006: Long-Sheng Song; Eric Sobie; Stacey L McCulle; William Lederer; C William Balke; Heping Cheng
Orphaned ryanodine receptors in the failing heart.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4305-10.
2006: Eric Sobie; Silvia Guatimosim; Leticia Gómez-Viquez; Long-Sheng Song; Hali Hartmann; M Saleet Jafri; William Lederer
The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice.
Progress in biophysics and molecular biology 2006;90(1-3):172-85.
2005: Long-Sheng Song; Silvia Guatimosim; Leticia Gómez-Viquez; Eric Sobie; Andrew P Ziman; Hali Hartmann; William Lederer
Calcium biology of the transverse tubules in heart.
Annals of the New York Academy of Sciences 2005;1047():99-111.
2005: Eric Sobie; Long-Sheng Song; William Lederer
Local recovery of Ca2+ release in rat ventricular myocytes.
The Journal of physiology 2005;565(Pt 2):441-7.
2005: Harry Knot; Ismail Laher; Eric Sobie; Silvia Guatimosim; Leticia Gomez-Viquez; Hali Hartmann; Long-Sheng Song; William Lederer; Wolfgang F. Graier; Roland Malli; Maud Frieden; Ole H Petersen
Twenty years of calcium imaging: cell physiology to dye for.
Molecular interventions 2005;5(2):112-27.
2004: W Jonathan Lederer; Silvia Gmosim; Long-Sheng Song; Eric Sobie; Hali Hartmann; Valeriy Lukyanenko
Ca2+ sparks in heart muscle.
Journal of muscle research and cell motility 2004;25(8):602-3.
2003: Eric Sobie; Silvia Guatimosim; Long-Sheng Song; William Lederer
The challenge of molecular medicine: complexity versus Occam's razor.
The Journal of clinical investigation 2003;111(6):801-3.
2002: Silvia Guatimosim; Keith Dilly; Luis F Santana; M Saleet Jafri; Eric Sobie; William Lederer
Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient.
Journal of molecular and cellular cardiology 2002;34(8):941-50.
2002: Eric Sobie; Keith Dilly; Jader dos Santos Cruz; William Lederer; M Saleet Jafri
Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.
Biophysical journal 2002;83(1):59-78.
2001: Silvia Guatimosim; Eric Sobie; Jader dos Santos Cruz; L A Martin; William Lederer
Molecular identification of a TTX-sensitive Ca(2+) current.
American journal of physiology. Cell physiology 2001;280(5):C1327-39.
1999: D K Cheng; Leslie Tung; Eric Sobie
Nonuniform responses of transmembrane potential during electric field stimulation of single cardiac cells.
The American journal of physiology 1999;277(1 Pt 2):H351-62.
1999: Robert C Susil; Eric Sobie; Leslie Tung
Separation between virtual sources modifies the response of cardiac tissue to field stimulation.
Journal of cardiovascular electrophysiology 1999;10(5):715-27.
1998: Tara L Riemer; Eric Sobie; Leslie Tung
Stretch-induced changes in arrhythmogenesis and excitability in experimentally based heart cell models.
The American journal of physiology 1998;275(2 Pt 2):H431-42.
1998: Eric Sobie; Leslie Tung
Postshock potential gradients and dispersion of repolarization in cells stimulated with monophasic and biphasic waveforms.
Journal of cardiovascular electrophysiology 1998;9(7):743-56.
1997: Eric Sobie; Robert C Susil; Leslie Tung
A generalized activating function for predicting virtual electrodes in cardiac tissue.
Biophysical journal 1997;73(3):1410-23.
1996: Matthew Fishler; Eric Sobie; Leslie Tung; Nitish V Thakor
Modeling the interaction between propagating cardiac waves and monophasic and biphasic field stimuli: the importance of the induced spatial excitatory response.
Journal of cardiovascular electrophysiology 1996;7(12):1183-96.
1996: Matthew Fishler; Eric Sobie; Nitish V Thakor; Leslie Tung
Mechanisms of cardiac cell excitation with premature monophasic and biphasic field stimuli: a model study.
Biophysical journal 1996;70(3):1347-62.
1995: Matthew Fishler; Eric Sobie; Leslie Tung; Nitish V Thakor
Cardiac responses to premature monophasic and biphasic field stimuli. Results from cell and tissue modeling studies.
Journal of electrocardiology 1995;28 Suppl():174-9.