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petra nederlof

Research Profile

Disorders

Chemicals & Drugs

Phenomena

Nucleic Acid Hybridization

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Genes & Molecular Sequences

BRCA1 Genes

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Florentine S Hilbers; Nicoline Hoogerbrugge; Jeroen F J Laros; Carel Meijers; petra nederlof; Christi J van Asperen; Michiel van Galen; Hans F A Vasen; Juul T Wijnen; Peter Devilee
Exome sequencing of germline DNA from non-BRCA1/2 familial breast cancer cases selected on the basis of aCGH tumor profiling.
Simon A Joosse; Kim I M Brandwijk; Peter Devilee; Frans B L Hogervorst; Senno Verhoef; Jelle Wesseling; petra nederlof
Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH.
E H Lips; I A M Mandjes; L Mulder; petra nederlof; A Vincent; M T F D Vrancken Peeters; J Wesseling; J J de Ronde; S Rodenhuis
Neoadjuvant chemotherapy in ER+ HER2- breast cancer: response prediction based on immunohistochemical and molecular characteristics.

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2013: Florentine S Hilbers; Nicoline Hoogerbrugge; Jeroen F J Laros; Carel Meijers; petra nederlof; Christi J van Asperen; Michiel van Galen; Hans F A Vasen; Juul T Wijnen; Peter Devilee
Exome sequencing of germline DNA from non-BRCA1/2 familial breast cancer cases selected on the basis of aCGH tumor profiling.
PloS one 2013;8(1):e55734.
2012: Simon A Joosse; Kim I M Brandwijk; Peter Devilee; Frans B L Hogervorst; Senno Verhoef; Jelle Wesseling; petra nederlof
Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH.
Breast cancer research and treatment 2012;132(2):379-89.
2012: E H Lips; I A M Mandjes; L Mulder; petra nederlof; A Vincent; M T F D Vrancken Peeters; J Wesseling; J J de Ronde; S Rodenhuis
Neoadjuvant chemotherapy in ER+ HER2- breast cancer: response prediction based on immunohistochemical and molecular characteristics.
Breast cancer research and treatment 2012;131(3):827-36.
2011: Sybren L Meijer; petra nederlof; Henrique Ruijter; Vincent T Smit; Lotus Sterk; Jan Willem Arends; Gerrit K J Hooijer; Mike Kliffen; Joost M van Gorp; Jelle Wesseling; Marc J van de Vijver
HER2 gene amplification in patients with breast cancer with equivocal IHC results.
Journal of clinical pathology 2011;64(12):1069-72.
2011: M A Didraga; Frans B L Hogervorst; Nicoline Hoogerbrugge; S A Joosse; M J L Ligtenberg; Rogier A Oldenburg; E H van Beers; Senno Verhoef; Lodewyk F A Wessels; K I M Brandwijk; Peter Devilee; petra nederlof
A non-BRCA1/2 hereditary breast cancer sub-group defined by aCGH profiling of genetically related patients.
Breast cancer research and treatment 2011;130(2):425-36.
2011: Quan Zhu; Fred H Gage; Alexis M Huynh; petra nederlof; Gerald M Pao; Hoonkyo Suh; Nina Tonnu; Inder M Verma
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.
Nature 2011;477(7363):179-84.
2011: M A Vollebergh; Jelle Wesseling; L F A Wessels; S Cornelissen; M de Bruin; E G E de Vries; F E Froklage; M Hauptmann; M Holtkamp; E H Lips; petra nederlof; S Rodenhuis; Marjanka K Schmidt; J G Schrama; E H van Beers; Marc J van de Vijver; Harm van Tinteren; Sabine C Linn
An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2011;22(7):1561-70.
2011: E H Lips; L Mulder; J Hannemann; N Laddach; M T F D Vrancken Peeters; M J van de Vijver; J Wesseling; petra nederlof; S Rodenhuis
Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2011;22(4):870-6.
2011: Ronald S A de Vreeze; Daphne de Jong; Wim Koops; petra nederlof; Aafke Ariaens; Rick L M Haas; Frits van Coevorden
Oncogenesis and classification of mixed-type liposarcoma: a radiological, histopathological and molecular biological analysis.
International journal of cancer. Journal international du cancer 2011;128(4):778-86.
2011: Simon A Joosse; Kim I M Brandwijk; Lennart Mulder; Jelle Wesseling; Juliane Hannemann; petra nederlof
Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors.
Genes, chromosomes & cancer 2011;50(2):71-81.
2011: Esther H Lips; petra nederlof; Anne M M Oonk; Suvi P Savola; Marieke A Vollebergh; Jelle Wesseling; Lodewyk F A Wessels; Alex L T Imholz; Nadja Laddach; Sjoerd Rodenhuis
Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness.
Breast cancer research : BCR 2011;13(5):R107.
2011: Ronald S A de Vreeze; Frits van Coevorden; Lucie Boerrigter; petra nederlof; Rick L M Haas; Johannes Bras; Andreas Rosenwald; Thomas Mentzel; Daphne de Jong
Delineation of chondroid lipoma: an immunohistochemical and molecular biological analysis.
Sarcoma 2011;2011():638403.
2011: Erik Thunnissen; petra nederlof; Egbert F Smit; Anne-Marie C Dingemans
[EGFR-mutation in non-small cell lung carcinoma. Treatment with tyrosine kinase inhibitors possible].
Nederlands tijdschrift voor geneeskunde 2011;155():A2554.
2011: Ronald van Eijk; Jappe Licht; Melanie Schrumpf; Mehrdad Talebian Yazdi; Dina Ruano; Giusi I Forte; petra nederlof; Maud Veselic; Klaus F Rabe; Jouke T Annema; Vincent Smit; Hans Morreau; Tom van Wezel
Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.
PloS one 2011;6(3):e17791.
2010: Renske Fles; Wilhelmina E Hoogendoorn; Inge Platteel; Caroline E Scheerman; Gerie de Leeuw-Mantel; Marian J E Mourits; Harry Hollema; Flora E van Leeuwen; Hester Van Boven; petra nederlof
Genomic profile of endometrial tumors depends on morphological subtype, not on tamoxifen exposure.
Genes, chromosomes & cancer 2010;49(8):699-710.
2010: Ronald S A de Vreeze; Daphne de Jong; petra nederlof; Aafke Ariaens; Ivon H G Tielen; Luc Frenken; Rick L M Haas; Frits van Coevorden
Added Value of Molecular Biological Analysis in Diagnosis and Clinical Management of Liposarcoma: A 30-Year Single-Institution Experience.
Annals of surgical oncology 2010;17(3):686-93.
2010: Ronald de Vreeze; Daphne de Jong; petra nederlof; Henrique J Ruijter; Lucie Boerrigter; Rick Haas; Frits van Coevorden
Multifocal myxoid liposarcoma--metastasis or second primary tumor?: a molecular biological analysis.
The Journal of molecular diagnostics : JMD 2010;12(2):238-43.
2010: Hugo M Horlings; Carmen Lai; Dimitry S A Nuyten; Hans Halfwerk; Petra M P Kristel; erik van beers; Simon A Joosse; Christiaan Klijn; petra nederlof; Marcel J T Reinders; Lodewyk F A Wessels; Marc J van de Vijver
Integration of DNA copy number alterations and prognostic gene expression signatures in breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(2):651-63.
2010: Henne Holstege; Hugo M Horlings; Arno Velds; Anita Langerød; Anne-Lise Børresen-Dale; Marc J van de Vijver; petra nederlof; Jos Jonkers
BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations.
BMC cancer 2010;10():654.
2010: Henne Holstege; erik van beers; Arno Velds; Xiaoling Liu; Simon A Joosse; Sjoerd Klarenbeek; Eva Schut; Ron Kerkhoven; Christiaan N Klijn; Lodewyk F A Wessels; petra nederlof; Jos Jonkers
Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.
BMC cancer 2010;10():455.
2009: Simon A Joosse; Erik H van Beers; Ivon H G Tielen; Hugo Horlings; Johannes L Peterse; Nicoline Hoogerbrugge; M J L Ligtenberg; Lodewyk F A Wessels; Priscilla Axwijk; Senno Verhoef; Frans B L Hogervorst; petra nederlof
Prediction of BRCA1-association in hereditary non-BRCA1/2 breast carcinomas with array-CGH.
Breast cancer research and treatment 2009;116(3):479-89.
2009: Taru A Koski; Heli J Lehtonen; Kowan J Jee; Shinsuke Ninomiya; Simon A Joosse; Pia Vahteristo; Maija Kiuru; Auli Karhu; Heli Sammalkorpi; Sakari Vanharanta; Rainer Lehtonen; Henrik Edgren; petra nederlof; Marja Hietala; Kristiina Aittomäki; Riitta Herva; Sakari Knuutila; Lauri A Aaltonen; Virpi Launonen
Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer.
Genes, chromosomes & cancer 2009;48(7):544-51.
2009: Ans M W van den Ouweland; Winand N M Dinjens; Lambert C J Dorssers; Monique M van Veghel-Plandsoen; Hennie T Brüggenwirth; Caroline J Withagen-Hermans; Johanna Margriet Collée; Simon A Joosse; Joan N R Terlouw-Kromosoeto; petra nederlof
Deletion of exons 1a-2 of BRCA1: a rather frequent pathogenic abnormality.
Genetic testing and molecular biomarkers 2009;13(3):399-406.
2009: Henne Holstege; Simon A Joosse; Conny Th M van Oostrom; petra nederlof; Annemieke de Vries; Jos Jonkers
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.
Cancer research 2009;69(8):3625-33.
2009: T W Geurts; Marie-Louise F Van Velthuysen; F Broekman; T Hooft van Huysduynen; Michiel van den Brekel; nico van zandwijk; Harm van Tinteren; petra nederlof; A J M Balm; R H Brakenhoff
Differential diagnosis of pulmonary carcinoma following head and neck cancer by genetic analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):980-5.
2009: Ronald S A de Vreeze; Daphne de Jong; Ivon H G Tielen; Henrique J Ruijter; petra nederlof; Rick L M Haas; Frits van Coevorden
Primary retroperitoneal myxoid/round cell liposarcoma is a nonexisting disease: an immunohistochemical and molecular biological analysis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(2):223-31.
2009: Julian Puppe; Rinske Drost; Xiaoling Liu; Simon A Joosse; Bastiaan Evers; Paulien Cornelissen-Steijger; petra nederlof; Qiang Yu; Jos Jonkers; Maarten van Lohuizen; Alexandra M Pietersen
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.
Breast cancer research : BCR 2009;11(4):R63.
2008: Rogier A Oldenburg; Karin H G Kroeze-Jansema; Jeanine J Houwing-Duistermaat; Jean-Pierre Bayley; Cheryl Dambrot; Christi J van Asperen; Ans M W van den Ouweland; Bert Bakker; erik van beers; petra nederlof; H F A Vasen; Nicoline Hoogerbrugge; Cees J Cornelisse; Hanne Meijers-Heijboer; Peter Devilee
Genome-wide linkage scan in Dutch hereditary non-BRCA1/2 breast cancer families identifies 9q21-22 as a putative breast cancer susceptibility locus.
Genes, chromosomes & cancer 2008;47(11):947-56.
2008: Wilhelmina E Hoogendoorn; Harry Hollema; Hester H van Boven; Elisabeth Bergman; Geri de Leeuw-Mantel; Inge Platteel; Renske Fles; petra nederlof; Marian J E Mourits; Flora E van Leeuwen
Prognosis of uterine corpus cancer after tamoxifen treatment for breast cancer.
Breast cancer research and treatment 2008;112(1):99-108.
2008: Marc Tischkowitz; Nancy Hamel; Marcelo A Carvalho; Gabriel Birrane; Aditi Soni; erik van beers; Simon A Joosse; Nora Wong; David Novak; Louise A Quenneville; Scott Grist; petra nederlof; David E Goldgar; Sean V Tavtigian; Alvaro Monteiro; John A A Ladias; William D Foulkes
Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.
European journal of human genetics : EJHG 2008;16(7):820-32.
2007: Susanne Van Eeden; G Johan A Offerhaus; Augustinus A M Hart; Lucie Boerrigter; petra nederlof; E Porter; Marie-Louise F Van Velthuysen
Goblet cell carcinoid of the appendix: a specific type of carcinoma.
Histopathology 2007;51(6):763-73.
2007: Marc Tischkowitz; Bing Xia; Nelly Sabbaghian; Jorge S Reis-Filho; Nancy Hamel; Guilan Li; erik van beers; Lili Li; Tayma Khalil; Louise A Quenneville; Atilla Omeroglu; Aletta Poll; Pierre Lepage; Nora Wong; petra nederlof; Alan Ashworth; Patricia N Tonin; Steven A Narod; David M Livingston; William D Foulkes
Analysis of PALB2/FANCN-associated breast cancer families.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6788-93.
2007: Carmen Lai; Hugo M Horlings; Marc J van de Vijver; erik van beers; petra nederlof; Lodewyk F A Wessels; Marcel J T Reinders
SIRAC: Supervised Identification of Regions of Aberration in aCGH datasets.
BMC bioinformatics 2007;8():422.
2007: Simon A Joosse; erik van beers; petra nederlof
Automated array-CGH optimized for archival formalin-fixed, paraffin-embedded tumor material.
BMC cancer 2007;7():43.
2007: nico van zandwijk; A Mathy; Lucie Boerrigter; H Ruijter; I Tielen; Daphne de Jong; Paul Baas; Sjaak A Burgers; petra nederlof
EGFR and KRAS mutations as criteria for treatment with tyrosine kinase inhibitors: retro- and prospective observations in non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(1):99-103.
2006: erik van beers; S A Joosse; M J L Ligtenberg; R Fles; Frans B L Hogervorst; Senno Verhoef; petra nederlof
A multiplex PCR predictor for aCGH success of FFPE samples.
British journal of cancer 2006;94(2):333-7.
2006: erik van beers; petra nederlof
Array-CGH and breast cancer.
Breast cancer research : BCR 2006;8(3):210.
2005: Tom W Geurts; petra nederlof; Michiel van den Brekel; Laura J van't Veer; Daphne de Jong; Augustinus A M Hart; nico van zandwijk; Houke Klomp; Alfons J M Balm; Marie-Louise F Van Velthuysen
Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: metastasis or second primary?
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(18):6608-14.
2005: erik van beers; Tibor van Welsem; Lodewyk F A Wessels; Yunlei Li; Rogier A Oldenburg; Peter Devilee; Cees J Cornelisse; Senno Verhoef; Frans B L Hogervorst; Laura J van't Veer; petra nederlof
Comparative genomic hybridization profiles in human BRCA1 and BRCA2 breast tumors highlight differential sets of genomic aberrations.
Cancer research 2005;65(3):822-7.
2004: Frederik B J M Thunnissen; M G J Tilanus; M J L Ligtenberg; petra nederlof; Winand N M Dinjens; E Meulemans; Adriaan J C van den Brule; Carel J M van Noesel; W J F de Leeuw; Ed Schuuring
Quality control in diagnostic molecular pathology in the Netherlands; proficiency testing for patient identification in tissue samples.
Journal of clinical pathology 2004;57(7):717-20.
2003: Els C Robanus-Maandag; Cathy A J Bosch; Petra M P Kristel; Augustinus A M Hart; Ian F Faneyte; petra nederlof; Johannes L Peterse; Marc J van de Vijver
Association of C-MYC amplification with progression from the in situ to the invasive stage in C-MYC-amplified breast carcinomas.
The Journal of pathology 2003;201(1):75-82.
2003: Daphne de Jong; Annuska M Glas; Lucie Boerrigter; Marie-Christine Hermus; Otilia Dalesio; Els Willemse; petra nederlof; Marie José Kersten
Very late relapse in diffuse large B-cell lymphoma represents clonally related disease and is marked by germinal center cell features.
Blood 2003;102(1):324-7.
2003: Frans B L Hogervorst; petra nederlof; Johan J P Gille; Cathal J McElgunn; Maartje Grippeling; Roelof Pruntel; Rein Regnerus; Tibor van Welsem; Rosalina Spaendonk; Fred H Menko; Irma Kluijt; Charlotte Dommering; Senno Verhoef; Jan P Schouten; Laura J van't Veer; Gerard Pals
Large genomic deletions and duplications in the BRCA1 gene identified by a novel quantitative method.
Cancer research 2003;63(7):1449-53.
2002: Lodewyk F A Wessels; Tibor van Welsem; Augustinus A M Hart; Laura J van't Veer; Marcel J T Reinders; petra nederlof
Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors.
Cancer research 2002;62(23):7110-7.
2002: Johan J P Gille; Frans B L Hogervorst; Gerard Pals; Juul Wijnen; R J van Schooten; Charlotte Dommering; Gerrit A Meijer; Mikael E Craanen; petra nederlof; Daphne de Jong; Cathal J McElgunn; Jan P Schouten; Fred H Menko
Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach.
British journal of cancer 2002;87(8):892-7.
2002: Susanne Van Eeden; petra nederlof; Babs G Taal; G Johan A Offerhaus; Marie-Louise F Van Velthuysen
A tumour with a neuroendocrine and papillary serous component: two or a pair?
Journal of clinical pathology 2002;55(9):710-4.
2000: Jacqueline J L Jacobs; P Keblusek; Els C Robanus-Maandag; Petra M P Kristel; Merel Lingbeek; petra nederlof; Tibor van Welsem; Marc J van de Vijver; Eugene Koh; George Q Daley; Maarten van Lohuizen
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.
Nature genetics 2000;26(3):291-9.
1999: J Mayr; H R Wang; petra nederlof; Wolfgang Baumeister
The import pathway of human and Thermoplasma 20S proteasomes into HeLa cell nuclei is different from that of classical NLS-bearing proteins.
Biological chemistry 1999;380(10):1183-92.
1997: H R Wang; M Kania; Wolfgang Baumeister; petra nederlof
Import of human and Thermoplasma 20S proteasomes into nuclei of HeLa cells requires functional NLS sequences.
European journal of cell biology 1997;73(2):105-13.
1996: D Stock; petra nederlof; Erika Seemüller; Wolfgang Baumeister; Robert Huber; Jan Löwe
Proteasome: from structure to function.
Current opinion in biotechnology 1996;7(4):376-85.
1995: petra nederlof; H R Wang; Wolfgang Baumeister
Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12060-4.
1995: J Wang; H S Basu; L Hu; Burt Feuerstein; petra nederlof; Dennis F Deen
Radiation-induced changes in nucleoid halo diameters of aerobic and hypoxic SF-126 human brain tumor cells.
Cytometry 1995;19(2):107-11.
1994: C T Thompson; P E LeBoit; petra nederlof; Joe Gray
Thick-section fluorescence in situ hybridization on formalin-fixed, paraffin-embedded archival tissue provides a histogenetic profile.
The American journal of pathology 1994;144(2):237-43.
1992: H Roelofs; petra nederlof; J G Tasseron-de Jong; P van de Putte; Micheline Giphart-Gassler
Gene amplification in human cells may involve interchromosomal transposition and persistence of the original DNA region.
The New biologist 1992;4(1):75-86.
1992: petra nederlof; S van der Flier; Nico P Verwoerd; J Vrolijk; Anton K Raap; Hans J Tanke
Quantification of fluorescence in situ hybridization signals by image cytometry.
Cytometry 1992;13(8):846-52.
1992: petra nederlof; S van der Flier; J Vrolijk; Hans J Tanke; Anton K Raap
Fluorescence ratio measurements of double-labeled probes for multiple in situ hybridization by digital imaging microscopy.
Cytometry 1992;13(8):839-45.
1992: petra nederlof; S van der Flier; Anton K Raap; Hans J Tanke
Quantification of inter- and intra-nuclear variation of fluorescence in situ hybridization signals.
Cytometry 1992;13(8):831-8.
1991: Joop Wiegant; T Ried; petra nederlof; M van der Ploeg; Hans J Tanke; Anton K Raap
In situ hybridization with fluoresceinated DNA.
Nucleic acids research 1991;19(12):3237-41.
1990: petra nederlof; S van der Flier; Joop Wiegant; Anton K Raap; Hans J Tanke; J S Ploem; M van der Ploeg
Multiple fluorescence in situ hybridization.
Cytometry 1990;11(1):126-31.
1990: M H Pieters; Joep P M Geraedts; H Meyer; John C M Dumoulin; Johannes Evers; R J Jongbloed; petra nederlof; S van der Flier
Human gametes and zygotes studied by nonradioactive in situ hybridization.
Cytogenetics and cell genetics 1990;53(1):15-9.
1989: petra nederlof; S van der Flier; Anton K Raap; Hans J Tanke; M van der Ploeg; F Kornips; Joep P M Geraedts
Detection of chromosome aberrations in interphase tumor nuclei by nonradioactive in situ hybridization.
Cancer genetics and cytogenetics 1989;42(1):87-98.
1989: petra nederlof; D Robinson; R Abuknesha; Joop Wiegant; Anton H N Hopman; Hans J Tanke; Anton K Raap
Three-color fluorescence in situ hybridization for the simultaneous detection of multiple nucleic acid sequences.
Cytometry 1989;10(1):20-7.