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Sidney Hecht

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
12
Deng, Jing-Zhen
12
Gao, Rong
12
Jones, Shannon
10
Eisenhauer, Brian
10
Starck, Shelley
9
Leitheiser, Christopher
9
Ma, Ji
9
Maloney, David
8
Kingston, David
8
Tao, Zhi-Fu
7
Thomas, Craig
7
Wang, Bixun
7
Dedkova, Larisa
6
Claeboe, Christopher
6
Golovine, Serguei

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Publications

TOP 3
Hecht Sidney M
Nucleic acids: expanding the structural and functional horizons.
Chapuis Jean-Charles; Khdour Omar; Cai Xiaoqing; Lu Jun; Hecht Sidney M
Synthesis and characterization of Deltalac-acetogenins that potently inhibit mitochondrial complex I.
Chapuis Jean-Charles; Schmaltz Ryan M; Tsosie Krystal S; Belohlavek Marek; Hecht Sidney M
Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates.

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All Publications

2009: Hecht Sidney M
Nucleic acids: expanding the structural and functional horizons.
Journal of the American Chemical Society 2009;131(11):3791-3.
2009: Chapuis Jean-Charles; Khdour Omar; Cai Xiaoqing; Lu Jun; Hecht Sidney M
Synthesis and characterization of Deltalac-acetogenins that potently inhibit mitochondrial complex I.
Bioorganic & medicinal chemistry 2009;17(6):2204-9.
2009: Chapuis Jean-Charles; Schmaltz Ryan M; Tsosie Krystal S; Belohlavek Marek; Hecht Sidney M
Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates.
Journal of the American Chemical Society 2009;131(7):2438-9.
2009: Ma Qian; Akiyama Yoshitsugu; Xu Zhidong; Konishi Kazuhide; Hecht Sidney M
Identification and cleavage site analysis of DNA sequences bound strongly by bleomycin.
Journal of the American Chemical Society 2009;131(5):2013-22.
2008: Chen Shengxi; Hecht Sidney M
Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine.
Bioorganic & medicinal chemistry 2008;16(19):9023-31.
2008: Khan Qasim A; Elban Mark A; Hecht Sidney M
The topopyrones poison human DNA topoisomerases I and II.
Journal of the American Chemical Society 2008;130(39):12888-9.
2008: Duca Maria; Chen Shengxi; Hecht Sidney M
Modeling the reactive properties of tandemly activated tRNAs.
Organic & biomolecular chemistry 2008;6(18):3292-9.
2008: Akiyama Yoshitsugu; Ma Qian; Edgar Erin; Laikhter Andrei; Hecht Sidney M
Identification of strong DNA binding motifs for bleomycin.
Journal of the American Chemical Society 2008;130(30):9650-1.
2008: Akiyama Yoshitsugu; Ma Qian; Edgar Erin; Laikhter Andrei; Hecht Sidney M
A novel DNA hairpin substrate for bleomycin.
Organic letters 2008;10(11):2127-30.
2008: Yakovleva Lyudmila; Chen Shengxi; Hecht Sidney M; Shuman Stewart
Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.
The Journal of biological chemistry 2008;283(23):16093-103.
2008: Gao Zhijie; Maloney David J; Dedkova Larisa M; Hecht Sidney M
Inhibitors of DNA polymerase beta: activity and mechanism.
Bioorganic & medicinal chemistry 2008;16(8):4331-40.
2008: Duca Maria; Chen Shengxi; Hecht Sidney M
Aminoacylation of transfer RNAs with one and two amino acids.
Methods (San Diego, Calif.) 2008;44(2):87-99.
2008: Elban Mark A; Hecht Sidney M
Total synthesis of the topopyrones: a new class of topoisomerase I poisons.
The Journal of organic chemistry 2008;73(3):785-93.
2007: Ma Qian; Xu Zhidong; Schroeder Benjamin R; Sun Wenyue; Wei Fang; Hashimoto Shigeki; Konishi Kazuhide; Leitheiser Christopher J; Hecht Sidney M
Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties.
Journal of the American Chemical Society 2007;129(41):12439-52.
2007: Maloney David J; Ghanem Noha; Zhou Jia; Hecht Sidney M
Positional assignment of differentially substituted bisaminoacylated pdCpAs.
Organic & biomolecular chemistry 2007;5(19):3135-8.
2007: Elban Mark A; Chapuis Jean C; Li Mei; Hecht Sidney M
Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines.
Bioorganic & medicinal chemistry 2007;15(18):6119-25.
2007: Karginov Vladimir A; Nestorovich Ekaterina M; Schmidtmann Frank; Robinson Tanisha M; Yohannes Adiamseged; Fahmi Nour Eddine; Bezrukov Sergey M; Hecht Sidney M
Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives.
Bioorganic & medicinal chemistry 2007;15(16):5424-31.
2007: Smith Jeffrey A; Maloney David J; Hecht Sidney M; Lannigan Deborah A
Structural basis for the activity of the RSK-specific inhibitor, SL0101.
Bioorganic & medicinal chemistry 2007;15(14):5018-34.
2007: Duca Maria; Maloney David J; Lodder Michiel; Wang Bixun; Hecht Sidney M
Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs.
Bioorganic & medicinal chemistry 2007;15(13):4629-42.
2007: Choudhury Ambar K; Golovine Serguei Y; Dedkova Larisa M; Hecht Sidney M
Synthesis of proteins containing modified arginine residues.
Biochemistry 2007;46(13):4066-76.
2007: Fahmi Nour Eddine; Dedkova Larisa; Wang Bixun; Golovine Serguei; Hecht Sidney M
Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins.
Journal of the American Chemical Society 2007;129(12):3586-97.
2007: Klarmann George J; Eisenhauer Brian M; Zhang Yi; Gotte Matthias; Pata Janice D; Chatterjee Deb K; Hecht Sidney M; Le Grice Stuart F J
Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids.
Biochemistry 2007;46(8):2118-26.
2006: Dedkova Larisa M; Fahmi Nour Eddine; Golovine Serguei Y; Hecht Sidney M
Construction of modified ribosomes for incorporation of D-amino acids into proteins.
Biochemistry 2006;45(51):15541-51.
2006: Tao Zhi-Fu; Konishi Kazuhide; Keith Gérard; Hecht Sidney M
An efficient mammalian transfer RNA target for bleomycin.
Journal of the American Chemical Society 2006;128(46):14806-7.
2006: Karginov Vladimir A; Nestorovich Ekaterina M; Yohannes Adiamseged; Robinson Tanisha M; Fahmi Nour Eddine; Schmidtmann Frank; Hecht Sidney M; Bezrukov Sergey M
Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities.
Antimicrobial agents and chemotherapy 2006;50(11):3740-53.
2006: Nguyen Tam Luong; Gussio Rick; Smith Jeffrey A; Lannigan Deborah A; Hecht Sidney M; Scudiero Dominic A; Shoemaker Robert H; Zaharevitz Daniel W
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.
Bioorganic & medicinal chemistry 2006;14(17):6097-105.
2006: Smith Jeffrey A; Maloney David J; Clark David E; Xu Yaming; Hecht Sidney M; Lannigan Deborah A
Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.
Bioorganic & medicinal chemistry 2006;14(17):6034-42.
2006: Elban Mark A; Sun Wenyue; Eisenhauer Brian M; Gao Rong; Hecht Sidney M
Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin.
Organic letters 2006;8(16):3513-6.
2006: Gao Rong; Zhang Yi; Dedkova Larisa; Choudhury Ambar K; Rahier Nicolas J; Hecht Sidney M
Effects of modification of the active site tyrosine of human DNA topoisomerase I.
Biochemistry 2006;45(27):8402-10.
2006: Xu Ya-Ming; Smith Jeffrey A; Lannigan Deborah A; Hecht Sidney M
Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.
Bioorganic & medicinal chemistry 2006;14(11):3974-7.
2006: Wang Bixun; Zhou Jia; Lodder Michiel; Anderson Raymond D; Hecht Sidney M
Tandemly activated tRNAs as participants in protein synthesis.
The Journal of biological chemistry 2006;281(20):13865-8.
2006: Maloney David J; Chen Shengxi; Hecht Sidney M
Stereoselective synthesis of the atropisomers of myristinin B/C.
Organic letters 2006;8(9):1925-7.
2006: Clement Jason A; Li Mei; Hecht Sidney M; Kingston David G I
Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA.
Journal of natural products 2006;69(3):373-6.
2006: Arimondo Paola B; Thomas Craig J; Oussedik Kahina; Baldeyrou Brigitte; Mahieu Christine; Halby Ludovic; Guianvarc'h Dominique; Lansiaux Amélie; Hecht Sidney M; Bailly Christian; Giovannangeli Carine
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates.
Molecular and cellular biology 2006;26(1):324-33.
2006: Karginov Vladimir A; Yohannes Adiamseged; Robinson Tanisha M; Fahmi Nour Eddine; Alibek Kenneth; Hecht Sidney M
Beta-cyclodextrin derivatives that inhibit anthrax lethal toxin.
Bioorganic & medicinal chemistry 2006;14(1):33-40.
2005: Deng Jing-Zhen; Starck Shelley R; Li Shisheng; Hecht Sidney M
(+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA.
Journal of natural products 2005;68(11):1625-8.
2005: Maloney David J; Hecht Sidney M
A stereocontrolled synthesis of delta-trans-tocotrienoloic acid.
Organic letters 2005;7(19):4297-300.
2005: Nakanishi Ikuo; Nishizawa Chiho; Ohkubo Kei; Takeshita Keizo; Suzuki Kazuo T; Ozawa Toshihiko; Hecht Sidney M; Tanno Masayuki; Sueyoshi Shoko; Miyata Naoki; Okuda Haruhiro; Fukuzumi Shunichi; Ikota Nobuo; Fukuhara Kiyoshi
Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue.
Organic & biomolecular chemistry 2005;3(18):3263-5.
2005: Pham Van Cuong; Ma Ji; Thomas Shannon J; Xu Zhidong; Hecht Sidney M
Alkaloids from Alangium javanicum and Alangium grisolleoides that mediate Cu2+-dependent DNA strand scission.
Journal of natural products 2005;68(8):1147-52.
2005: Hecht Sidney M
Camptothecin: roles of the D and E rings in binding to the topoisomerase I-DNA covalent binary complex.
Current medicinal chemistry. Anti-cancer agents 2005;5(4):353-62.
2005: Lodder Michiel; Wang Bixun; Hecht Sidney M
The N-pentenoyl protecting group for aminoacyl-tRNAs.
Methods (San Diego, Calif.) 2005;36(3):245-51.
2005: Tian Ligeng; Claeboe Christopher D; Hecht Sidney M; Shuman Stewart
Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine.
Structure (London, England : 1993) 2005;13(4):513-20.
2005: Deng Jing-Zhen; Newman David J; Hecht Sidney M
Umbelactonyl cinnamate derivatives from Crypteronia paniculata that mediate DNA strand scission.
Journal of natural products 2005;68(3):465-7.
2005: Maloney David J; Deng Jing-Zhen; Starck Shelley R; Gao Zhijie; Hecht Sidney M
(+)-Myristinin A, a naturally occurring DNA polymerase beta inhibitor and potent DNA-damaging agent.
Journal of the American Chemical Society 2005;127(12):4140-1.
2005: Arimondo Paola B; Laco Gary S; Thomas Craig J; Halby Ludovic; Pez Didier; Schmitt Philippe; Boutorine Alexandre; Garestier Thérèse; Pommier Yves; Hecht Sidney M; Sun Jian-Sheng; Bailly Christian
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides.
Biochemistry 2005;44(11):4171-80.
2005: Maloney David J; Hecht Sidney M
Synthesis of a potent and selective inhibitor of p90 Rsk.
Organic letters 2005;7(6):1097-9.
2005: Gao Rong; Zhang Yi; Choudhury Ambar K; Dedkova Larisa M; Hecht Sidney M
Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine.
Journal of the American Chemical Society 2005;127(10):3321-31.
2005: Rahier Nicolas J; Cheng Kejun; Gao Rong; Eisenhauer Brian M; Hecht Sidney M
Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison.
Organic letters 2005;7(5):835-7.
2005: Smith Jeffrey A; Poteet-Smith Celeste E; Xu Yaming; Errington Timothy M; Hecht Sidney M; Lannigan Deborah A
Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.
Cancer research 2005;65(3):1027-34.
2005: Rahier Nicolas J; Eisenhauer Brian M; Gao Rong; Thomas Shannon J; Hecht Sidney M
On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I-DNA covalent binary complex.
Bioorganic & medicinal chemistry 2005;13(4):1381-6.
2005: Ma Ji; Jones Shannon H; Marshall Rebekah; Wu Xihan; Hecht Sidney M
DNA topoisomerase I inhibitors from Rinorea anguifera.
Bioorganic & medicinal chemistry letters 2005;15(3):813-6.
2005: Xu Ya-ming; Johnson Randall K; Hecht Sidney M
Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase.
Bioorganic & medicinal chemistry 2005;13(3):657-9.
2005: Ma Ji; Jones Shannon H; Hecht Sidney M
A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission.
Journal of natural products 2005;68(1):115-7.
2005: Cheng Kejun; Rahier Nicolas J; Eisenhauer Brian M; Gao Rong; Thomas S J; Hecht Sidney M
14-azacamptothecin: a potent water-soluble topoisomerase I poison.
Journal of the American Chemical Society 2005;127(3):838-9.
2004: Cagir Ali; Eisenhauer Brian M; Gao Rong; Thomas Shannon J; Hecht Sidney M
Synthesis and topoisomerase I inhibitory properties of luotonin A analogues.
Bioorganic & medicinal chemistry 2004;12(23):6287-99.
2004: Chaturvedula V S Prakash; Zhou Bing-Nan; Gao Zhijie; Thomas Shannon J; Hecht Sidney M; Kingston David G I
New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta.
Bioorganic & medicinal chemistry 2004;12(23):6271-5.
2004: Klarmann George J; Eisenhauer Brian M; Zhang Yi; Sitaraman Kalavathy; Chatterjee Deb K; Hecht Sidney M; Le Grice Stuart F J
Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase.
Protein expression and purification 2004;38(1):37-44.
2004: Feng Xizhi; Gao Zhijie; Li Shisheng; Jones Shannon H; Hecht Sidney M
DNA polymerase beta lyase inhibitors from Maytenus putterlickoides.
Journal of natural products 2004;67(10):1744-7.
2004: Cao Shugeng; Gao Zhijie; Thomas Shannon J; Hecht Sidney M; Lazo John S; Kingston David G I
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
Journal of natural products 2004;67(10):1716-8.
2004: Ma Ji; Jones Shannon H; Hecht Sidney M
A coumarin from Mallotus resinosus that mediates DNA cleavage.
Journal of natural products 2004;67(9):1614-6.
2004: Li Shi-Sheng; Gao Zhijie; Feng Xizhi; Hecht Sidney M
Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta.
Journal of natural products 2004;67(9):1608-10.
2004: Hu Hong-Yu; Horton Julie K; Gryk Michael R; Prasad Rajendra; Naron Jana M; Sun Di-An; Hecht Sidney M; Wilson Samuel H; Mullen Gregory P
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping.
The Journal of biological chemistry 2004;279(38):39736-44.
2004: Li Shi-Sheng; Gao Zhijie; Feng Xizhi; Jones Shannon H; Hecht Sidney M
Plant sterols as selective DNA polymerase beta lyase inhibitors and potentiators of bleomycin cytotoxicity.
Bioorganic & medicinal chemistry 2004;12(15):4253-8.
2004: Ma Ji; Jones Shannon H; Marshall Rebekah; Johnson Randall K; Hecht Sidney M
A DNA-damaging oxoaporphine alkaloid from Piper caninum.
Journal of natural products 2004;67(7):1162-4.
2004: Ma Ji; Jones Shannon H; Hecht Sidney M
Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum.
Bioorganic & medicinal chemistry 2004;12(14):3885-9.
2004: Prakash Chaturvedula V S; Hecht Sidney M; Gao Zhijie; Jones Shannon H; Feng Xizhi; Kingston David G I
New neolignans that inhibit DNA polymerase beta lyase.
Journal of natural products 2004;67(6):964-7.
2004: Chaturvedula V S Prakash; Gao Zhijie; Jones Shannon H; Feng Xizhi; Hecht Sidney M; Kingston David G I
A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase.
Journal of natural products 2004;67(5):899-901.
2004: Gao Rong; Claeboe Christopher D; Eisenhauer Brian M; Hecht Sidney M
Identification of specific nonbridging phosphate oxygens important for DNA cleavage by human topoisomerase I.
Biochemistry 2004;43(20):6167-81.
2004: Ma Ji; Hecht Sidney M
Javaniside, a novel DNA cleavage agent from Alangium javanicum having an unusual oxindole skeleton.
Chemical communications (Cambridge, England) 2004;(10):1190-1.
2004: Cagir Ali; Jones Shannon H; Eisenhauer Brian M; Gao Rong; Hecht Sidney M
Synthesis and biochemical properties of E-ring modified luotonin A derivatives.
Bioorganic & medicinal chemistry letters 2004;14(9):2051-4.
2004: Thomas Craig J; Rahier Nicolas J; Hecht Sidney M
Camptothecin: current perspectives.
Bioorganic & medicinal chemistry 2004;12(7):1585-604.
2004: Rahier Nicolas J; Eisenhauer Brian M; Gao Rong; Jones Shannon H; Hecht Sidney M
Water-soluble camptothecin derivatives that are intrinsic topoisomerase I poisons.
Organic letters 2004;6(3):321-4.
2004: Tian Ligeng; Claeboe Christopher D; Hecht Sidney M; Shuman Stewart
Remote phosphate contacts trigger assembly of the active site of DNA topoisomerase IB.
Structure (London, England : 1993) 2004;12(1):31-40.
2003: Leitheiser Christopher J; Hecht Sidney M
Solid-phase synthesis of deglycobleomycin and bleomycin.
Current opinion in drug discovery & development 2003;6(6):827-37.
2003: Prakash Chaturvedula V S; Gao Zhijie; Hecht Sidney M; Jones Shannon H; Kingston David G I
A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.
Journal of natural products 2003;66(11):1463-5.
2003: Cagir Ali; Tao Zhi-Fu; Sucheck Steven J; Hecht Sidney M
Solid-phase synthesis and biochemical evaluation of conformationally constrained analogues of deglycobleomycin A5.
Bioorganic & medicinal chemistry 2003;11(23):5179-87.
2003: Cagir Ali; Jones Shannon H; Gao Rong; Eisenhauer Brian M; Hecht Sidney M
Luotonin A. A naturally occurring human DNA topoisomerase I poison.
Journal of the American Chemical Society 2003;125(45):13628-9.
2003: Claeboe Christopher D; Gao Rong; Hecht Sidney M
3'-modified oligonucleotides by reverse DNA synthesis.
Nucleic acids research 2003;31(19):5685-91.
2003: Rishel Michael J; Thomas Craig J; Tao Zhi-Fu; Vialas Corine; Leitheiser Christopher J; Hecht Sidney M
Conformationally constrained analogues of bleomycin A5.
Journal of the American Chemical Society 2003;125(34):10194-205.
2003: Tian Ligeng; Claeboe Christopher D; Hecht Sidney M; Shuman Stewart
Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB.
Molecular cell 2003;12(1):199-208.
2003: Leitheiser Christopher J; Smith Kenneth L; Rishel Michael J; Hashimoto Shigeki; Konishi Kazuhide; Thomas Craig J; Li Chunhong; McCormick Michael M; Hecht Sidney M
Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library.
Journal of the American Chemical Society 2003;125(27):8218-27.
2003: Dedkova Larisa M; Fahmi Nour Eddine; Golovine Serguei Y; Hecht Sidney M
Enhanced D-amino acid incorporation into protein by modified ribosomes.
Journal of the American Chemical Society 2003;125(22):6616-7.
2003: Xu Ya-ming; Deng Jing-Zhen; Ma Ji; Chen Shao-Nong; Marshall Rebekah; Jones Shannon H; Johnson Randall K; Hecht Sidney M
DNA damaging activity of ellagic acid derivatives.
Bioorganic & medicinal chemistry 2003;11(7):1593-6.
2003: Abraham Anil T; Lin Jih-Jing; Newton Dianne L; Rybak Susanna; Hecht Sidney M
RNA cleavage and inhibition of protein synthesis by bleomycin.
Chemistry & biology 2003;10(1):45-52.
2002: Deng Jing-Zhen; Marshall Rebekah; Jones Shannon H; Johnson Randall K; Hecht Sidney M
DNA-damaging agents from Crypteronia paniculata.
Journal of natural products 2002;65(12):1930-2.
2002: Thomas Craig J; Chizhov Alexander O; Leitheiser Christopher J; Rishel Michael J; Konishi Kazuhide; Tao Zhi-Fu; Hecht Sidney M
Solid-phase synthesis of bleomycin A(5) and three monosaccharide analogues: exploring the role of the carbohydrate moiety in RNA cleavage.
Journal of the American Chemical Society 2002;124(44):12926-7.
2002: Eisenhauer Brian M; Hecht Sidney M
Site-specific incorporation of (aminooxy)acetic acid into proteins.
Biochemistry 2002;41(38):11472-8.
2002: Anderson Raymond D; Zhou Jia; Hecht Sidney M
Fluorescence resonance energy transfer between unnatural amino acids in a structurally modified dihydrofolate reductase.
Journal of the American Chemical Society 2002;124(33):9674-5.
2002: Zou Ying; Fahmi Nour Eddine; Vialas Corine; Miller Guy M; Hecht Sidney M
Total synthesis of deamido bleomycin a(2), the major catabolite of the antitumor agent bleomycin.
Journal of the American Chemical Society 2002;124(32):9476-88.
2002: Tao Zhi-Fu; Leitheiser Christopher J; Smith Kenneth L; Hashimoto Shigeki; Hecht Sidney M
Solid-phase synthesis of deglycobleomycins: a C-terminal tetraamine linker that permits direct evaluation of resin-bound bleomycins.
Bioconjugate chemistry 2002;13(3):426-34.
2002: Thomas Craig J; McCormick Michael M; Vialas Corine; Tao Zhi-Fu; Leitheiser Christopher J; Rishel Michael J; Wu Xihan; Hecht Sidney M
Alteration of the selectivity of DNA cleavage by a deglycobleomycin analogue containing a trithiazole moiety.
Journal of the American Chemical Society 2002;124(15):3875-84.
2002: Smith Kenneth L; Tao Zhi-Fu; Hashimoto Shigeki; Leitheiser Christopher J; Wu Xihan; Hecht Sidney M
Deglycobleomycin: solid-phase synthesis and DNA cleavage by the resin-bound ligand.
Organic letters 2002;4(7):1079-82.
2002: Wang Bixun; Brown Kathlynn C; Lodder Michiel; Craik Charles S; Hecht Sidney M
Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction.
Biochemistry 2002;41(8):2805-13.
2002: Arimondo Paola B; Boutorine Alexandre; Baldeyrou Brigitte; Bailly Christian; Kuwahara Masayasu; Hecht Sidney M; Sun Jian-Sheng; Garestier Thérèse; Hélène Claude
Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I.
The Journal of biological chemistry 2002;277(5):3132-40.
2001: Quada J C; Boturyn D; Hecht S M
Photoactivated DNA cleavage by compounds structurally related to the bithiazole moiety of bleomycin.
Bioorganic & medicinal chemistry 2001;9(9):2303-14.
2001: Keck M V; Manderville R A; Hecht S M
Chemical and structural characterization of the interaction of bleomycin A2 with d(CGCGAATTCGCG)2. efficient, double-strand DNA cleavage accessible without structural reorganization.
Journal of the American Chemical Society 2001;123(36):8690-700.
2001: Rishel M J; Hecht S M
Analogues of bleomycin: synthesis of conformationally rigid methylvalerates.
Organic letters 2001;3(18):2867-9.
2001: Sznaidman M L; Hecht S M
Studies on the total synthesis of tallysomycin. Synthesis of the threonylbithiazole moiety containing a structurally unique glycosylcarbinolamide.
Organic letters 2001;3(18):2811-4.
2001: Hashimoto S; Wang B; Hecht S M
Kinetics of DNA cleavage by Fe(II).bleomycins.
Journal of the American Chemical Society 2001;123(30):7437-8.
2001: Abraham A T; Zhou X; Hecht S M
Metallobleomycin-mediated cleavage of DNA not involving a threading-intercalation mechanism.
Journal of the American Chemical Society 2001;123(22):5167-75.
2001: Krogh B O; Claeboe C D; Hecht S M; Shuman S
Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase.
The Journal of biological chemistry 2001;276(24):20907-12.
2001: Choudhury A K; Tao Z F; Hecht S M
Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate.
Organic letters 2001;3(9):1291-4.
2001: Fahmi N E; Golovine S; Wang B; Hecht S M
Studies toward the site specific incorporation of sugars into proteins: synthesis of glycosylated aminoacyl-tRNAs.
Carbohydrate research 2001;330(2):149-64.
2000: Deng J Z; Starck S R; Sun D A; Sabat M; Hecht S M
A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta.
Journal of natural products 2000;63(10):1356-60.
2000: Leitheiser C J; Rishel M J; Wu X; Hecht S M
Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5).
Organic letters 2000;2(21):3397-9.
2000: Zhou B N; Hoch J M; Johnson R K; Mattern M R; Eng W K; Ma J; Hecht S M; Newman D J; Kingston D G
Use of COMPARE analysis to discover new natural product drugs: isolation of camptothecin and 9-methoxycamptothecin from a new source.
Journal of natural products 2000;63(9):1273-6.
2000: Deng J Z; Newman D J; Hecht S M
Use of COMPARE analysis to discover functional analogues of bleomycin.
Journal of natural products 2000;63(9):1269-72.
2000: Short G F; Laikhter A L; Lodder M; Shayo Y; Arslan T; Hecht S M
Probing the S1/S1' substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues.
Biochemistry 2000;39(30):8768-81.
2000: Starck S R; Deng J Z; Hecht S M
Naturally occurring alkylresorcinols that mediate DNA damage and inhibit its repair.
Biochemistry 2000;39(9):2413-9.
2000: Zhou B N; Johnson R K; Mattern M R; Wang X; Hecht S M; Beck H T; Ortiz A; Kingston D G
Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon.
Journal of natural products 2000;63(2):217-21.
2000: Deng J Z; Starck S R; Hecht S M
Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase beta.
Bioorganic & medicinal chemistry 2000;8(1):247-50.
2000: Hecht S M
Bleomycin: new perspectives on the mechanism of action.
Journal of natural products 2000;63(1):158-68.
2000: Hecht S M
Camptothecins as probes of the microenvironments of topoisomerase I--DNA complexes.
Annals of the New York Academy of Sciences 2000;922():76-91.
1999: Ma J; Starck S R; Hecht S M
DNA polymerase beta inhibitors from Tetracera boiviniana.
Journal of natural products 1999;62(12):1660-3.
1999: Deng J Z; Starck S R; Hecht S M
DNA polymerase beta inhibitors from Baeckea gunniana.
Journal of natural products 1999;62(12):1624-6.
1999: Sun D A; Starck S R; Locke E P; Hecht S M
DNA polymerase beta inhibitors from Sandoricum koetjape.
Journal of natural products 1999;62(8):1110-3.
1999: Karginov A V; Lodder M; Hecht S M
Facile characterization of translation initiation via nonsense codon suppression.
Nucleic acids research 1999;27(16):3283-90.
1999: Deng J Z; Starck S R; Hecht S M; Ijames C F; Hemling M E
Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata.
Journal of natural products 1999;62(7):1000-2.
1999: Short G F; Golovine S Y; Hecht S M
Effects of release factor 1 on in vitro protein translation and the elaboration of proteins containing unnatural amino acids.
Biochemistry 1999;38(27):8808-19.
1999: Wang X; Zhou X; Hecht S M
Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex.
Biochemistry 1999;38(14):4374-81.
1999: Deng J Z; Starck S R; Hecht S M
bis-5-Alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase beta.
Journal of natural products 1999;62(3):477-80.
1998: Wang X; Short G F; Kingsbury W D; Johnson R K; Hecht S M
Effects of camptothecin analogues on DNA transformations mediated by calf thymus and human DNA topoisomerases I.
Chemical research in toxicology 1998;11(11):1352-60.
1998: Wang X; Wang L K; Kingsbury W D; Johnson R K; Hecht S M
Differential effects of camptothecin derivatives on topoisomerase I-mediated DNA structure modification.
Biochemistry 1998;37(26):9399-408.
1998: Arslan T; Abraham A T; Hecht S M
DNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation.
The Journal of biological chemistry 1998;273(20):12383-90.
1998: Wang X; Henningfeld K A; Hecht S M
DNA topoisomerase I-mediated formation of structurally modified DNA duplexes. Effects of metal ions and topoisomerase I inhibitors.
Biochemistry 1998;37(8):2691-700.
1998: Arslan T; Abraham A T; Hecht S M
Structurally altered substrates for DNA topoisomerase I. Effects of inclusion of a single 3'-deoxynucleotide within the scissile strand.
Nucleosides & nucleotides 1998;17(1-3):515-30.
1997: Karginov V A; Mamaev S V; Hecht S M
In vitro suppression as a tool for the investigation of translation initiation.
Nucleic acids research 1997;25(19):3912-6.
1997: Holmes C E; Duff R J; van der Marel G A; van Boom J; Hecht S M
On the chemistry of RNA degradation by Fe.bleomycin.
Bioorganic & medicinal chemistry 1997;5(6):1235-48.
1996: Holmes C E; Abraham A T; Hecht S M; Florentz C; Giegé R
Fe.bleomycin as a probe of RNA conformation.
Nucleic acids research 1996;24(17):3399-406.
1996: Wang L K; Rogers B D; Hecht S M
Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne.
Chemical research in toxicology 1996;9(1):75-83.
1995: Kane S A; Hecht S M; Sun J S; Garestier T; Hélène C
Specific cleavage of a DNA triple helix by FeII.bleomycin.
Biochemistry 1995;34(51):16715-24.
1995: Morgan M A; Kazakov S A; Hecht S M
Phosphoryl migration during the chemical synthesis of RNA.
Nucleic acids research 1995;23(19):3949-53.
1995: Keck M V; Hecht S M
Sequence-specific hydrolysis of yeast tRNA(Phe) mediated by metal-free bleomycin.
Biochemistry 1995;34(37):12029-37.
1995: Henningfeld K A; Hecht S M
A model for topoisomerase I-mediated insertions and deletions with duplex DNA substrates containing branches, nicks, and gaps.
Biochemistry 1995;34(18):6120-9.
1994: Hecht S M
RNA degradation by bleomycin, a naturally occurring bioconjugate.
Bioconjugate chemistry 1994;5(6):513-26.
1994: Morgan M A; Hecht S M
Iron(II) bleomycin-mediated degradation of a DNA-RNA heteroduplex.
Biochemistry 1994;33(34):10286-93.
1994: Kane S A; Natrajan A; Hecht S M
On the role of the bithiazole moiety in sequence-selective DNA cleavage by Fe.bleomycin.
The Journal of biological chemistry 1994;269(14):10899-904.
1994: Kane S A; Hecht S M
Polynucleotide recognition and degradation by bleomycin.
Progress in nucleic acid research and molecular biology 1994;49():313-52.
1994: Van Atta R B; Hecht S M
A ribozyme model: site-specific cleavage of an RNA substrate by Mn2+.
Advances in inorganic biochemistry 1994;9():1-40.
1993: Holmes C E; Hecht S M
Fe.bleomycin cleaves a transfer RNA precursor and its "transfer DNA" analog at the same major site.
The Journal of biological chemistry 1993;268(34):25909-13.
1993: Wang L K; Johnson R K; Hecht S M
Inhibition of topoisomerase I function by nitidine and fagaronine.
Chemical research in toxicology 1993;6(6):813-8.
1993: Holmes C E; Carter B J; Hecht S M
Characterization of iron (II).bleomycin-mediated RNA strand scission.
Biochemistry 1993;32(16):4293-307.
1992: Resto E; Iida A; Van Cleve M D; Hecht S M
Amplification of protein expression in a cell free system.
Nucleic acids research 1992;20(22):5979-83.
1992: Hecht S M; Berry D E; MacKenzie L J; Busby R W; Nasuti C A
A strategy for identifying novel, mechanistically unique inhibitors of topoisomerase I.
Journal of natural products 1992;55(4):401-13.
1991: Nagai K; Hecht S M
Site-specific DNA cleavage by antisense oligonucleotides covalently linked to phenazine di-N-oxide.
The Journal of biological chemistry 1991;266(35):23994-4002.
1991: Berry D E; Chan J A; MacKenzie L; Hecht S M
9-Octadecynoic acid: a novel DNA binding agent.
Chemical research in toxicology 1991;4(2):195-8.
1991: Kingsbury W D; Boehm J C; Jakas D R; Holden K G; Hecht S M; Gallagher G; Caranfa M J; McCabe F L; Faucette L F; Johnson R K
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Journal of medicinal chemistry 1991;34(1):98-107.
1990: Surratt C K; Carter B J; Payne R C; Hecht S M
Metal ion and substrate structure dependence of the processing of tRNA precursors by RNase P and M1 RNA.
The Journal of biological chemistry 1990;265(36):22513-9.
1990: Surratt C K; Lesnikowski Z; Schifman A L; Schmidt F J; Hecht S M
Construction and processing of transfer RNA precursor models.
The Journal of biological chemistry 1990;265(36):22506-12.
1990: Carter B J; de Vroom E; Long E C; van der Marel G A; van Boom J H; Hecht S M
Site-specific cleavage of RNA by Fe(II).bleomycin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9373-7.
1990: Hertzberg R P; Busby R W; Caranfa M J; Holden K G; Johnson R K; Hecht S M; Kingsbury W D
Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site.
The Journal of biological chemistry 1990;265(31):19287-95.
1990: Dange V; Van Atta R B; Hecht S M
A Mn2(+)-dependent ribozyme.
Science (New York, N.Y.) 1990;248(4955):585-8.
1990: Carter B J; Vold B S; Hecht S M
Control of the position of RNase P-mediated transfer RNA precursor processing.
The Journal of biological chemistry 1990;265(13):7100-3.
1990: Van Atta R B; Bernadou J; Meunier B; Hecht S M
On the chemical nature of DNA and RNA modification by a hemin model system.
Biochemistry 1990;29(20):4783-9.
1990: Carter B J; Murty V S; Reddy K S; Wang S N; Hecht S M
A role for the metal binding domain in determining the DNA sequence selectivity of Fe-bleomycin.
The Journal of biological chemistry 1990;265(8):4193-6.
1989: Roesser J R; Xu C; Payne R C; Surratt C K; Hecht S M
Preparation of misacylated aminoacyl-tRNA(Phe)'s useful as probes of the ribosomal acceptor site.
Biochemistry 1989;28(12):5185-95.
1989: Hertzberg R P; Caranfa M J; Hecht S M
On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex.
Biochemistry 1989;28(11):4629-38.
1989: Sebti S M; DeLeon J C; Ma L T; Hecht S M; Lazo J S
Substrate specificity of bleomycin hydrolase.
Biochemical pharmacology 1989;38(1):141-7.
1988: Jäger A; Levy M J; Hecht S M
Oligonucleotide N-alkylphosphoramidates: synthesis and binding to polynucleotides.
Biochemistry 1988;27(19):7237-46.
1988: Heckler T G; Roesser J R; Xu C; Chang P I; Hecht S M
Ribosomal binding and dipeptide formation by misacylated tRNA(Phe),S.
Biochemistry 1988;27(19):7254-62.
1988: Barr J R; Murty V S; Yamaguchi K; Singh S; Smith D H; Hecht S M
5-Alkylresorcinols from Hakea amplexicaulis that cleave DNA.
Chemical research in toxicology 1988;1(4):204-7.
1988: Hertzberg R P; Caranfa M J; Hecht S M
Degradation of structurally modified DNAs by bleomycin group antibiotics.
Biochemistry 1988;27(9):3164-74.
1988: Levy M J; Hecht S M
Copper(II) facilitates bleomycin-mediated unwinding of plasmid DNA.
Biochemistry 1988;27(8):2647-50.
1988: Shipley J B; Hecht S M
Bleomycin congeners exhibiting altered DNA cleavage specificity.
Chemical research in toxicology 1988;1(1):25-7.
1988: Sugiyama H; Xu C; Murugesan N; Hecht S M; van der Marel G A; van Boom J H
Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG).
Biochemistry 1988;27(1):58-67.
1987: Payne R C; Nichols B P; Hecht S M
Escherichia coli tryptophan synthase: synthesis of catalytically competent alpha subunit in a cell-free system containing preacylated tRNAs.
Biochemistry 1987;26(11):3197-205.
1987: Ehrenfeld G M; Shipley J B; Heimbrook D C; Sugiyama H; Long E C; van Boom J H; van der Marel G A; Oppenheimer N J; Hecht S M
Copper-dependent cleavage of DNA by bleomycin.
Biochemistry 1987;26(3):931-42.
1986: Hecht S M
DNA strand scission by activated bleomycin group antibiotics.
Federation proceedings 1986;45(12):2784-91.
1986: Roesser J R; Chorghade M S; Hecht S M
Ribosome-catalyzed formation of an abnormal peptide analogue.
Biochemistry 1986;25(21):6361-5.
1986: Hertzberg R P; Hecht S M; Reynolds V L; Molineux I J; Hurley L H
DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs.
Biochemistry 1986;25(6):1249-58.
1986: Sugiyama H; Morii T; Saito I; Matsuura T; Hecht S M
Structure and chemistry of alkali-labile product formed during Fe(II)-bleomycin-mediated DNA strand scission.
Nucleic acids symposium series 1986;(17):165-6.
1985: Hsiang Y H; Hertzberg R; Hecht S; Liu L F
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
The Journal of biological chemistry 1985;260(27):14873-8.
1985: Sugiyama H; Ehrenfeld G M; Shipley J B; Kilkuskie R E; Chang L H; Hecht S M
DNA strand scission by bleomycin group antibiotics.
Journal of natural products 1985;48(6):869-77.
1985: Murugesan N; Xu C; Ehrenfeld G M; Sugiyama H; Kilkuskie R E; Rodriguez L O; Chang L H; Hecht S M
Analysis of products formed during bleomycin-mediated DNA degradation.
Biochemistry 1985;24(21):5735-44.
1985: Hertzberg R P; Caranfa M J; Hecht S M
DNA methylation diminishes bleomycin-mediated strand scission.
Biochemistry 1985;24(20):5286-9.
1985: Berry D E; Kilkuskie R E; Hecht S M
DNA damage induced by bleomycin in the presence of dibucaine is not predictive of cell growth inhibition.
Biochemistry 1985;24(13):3214-9.
1985: Berry D E; Chang L H; Hecht S M
DNA damage and growth inhibition in cultured human cells by bleomycin congeners.
Biochemistry 1985;24(13):3207-14.
1985: Che C T; Fang X D; Phoebe C H; Kinghorn A D; Farnsworth N R; Yellin B; Hecht S M
High-field 1H-NMR spectral analysis of some cucurbitacins.
Journal of natural products 1985;48(3):429-34.
1985: Ehrenfeld G M; Rodriguez L O; Hecht S M; Chang C; Basus V J; Oppenheimer N J
Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission.
Biochemistry 1985;24(1):81-92.
1984: Kilkuskie R E; Macdonald T L; Hecht S M
Bleomycin may be activated for DNA cleavage by NADPH-cytochrome P-450 reductase.
Biochemistry 1984;23(25):6165-71.
1984: Fang X; Phoebe C H; Pezzuto J M; Fong H H; Farnsworth N R; Yellin B; Hecht S M
Plant anticancer agents, XXXIV. Cucurbitacins from Elaeocarpus dolichostylus.
Journal of natural products 1984;47(6):988-93.
1984: Heckler T G; Chang L H; Zama Y; Naka T; Chorghade M S; Hecht S M
T4 RNA ligase mediated preparation of novel "chemically misacylated" tRNAPheS.
Biochemistry 1984;23(7):1468-73.
1983: Ehrenfeld G M; Francis T A; Hecht S M
Loss of positional specificity in the aminoacylation of Escherichia coli tRNAGly.
The Journal of biological chemistry 1983;258(19):11745-50.
1983: Heckler T G; Zama Y; Naka T; Hecht S M
Dipeptide formation with misacylated tRNAPhes.
The Journal of biological chemistry 1983;258(7):4492-5.
1983: Francis T A; Ehrenfeld G M; Gregory M R; Hecht S M
Transfer RNA pyrophosphorolysis with CTP(ATP):tRNA nucleotidyltransferase. A direct route to tRNAs modified at the 3' terminus.
The Journal of biological chemistry 1983;258(7):4279-84.
1983: Pellon J R; Sinskey A J; Hecht S M; Gomez R F
Kinetics of the bleomycin A2 damage in vivo to the folded chromosome of Escherichia coli.
Chemico-biological interactions 1983;43(2):245-51.
1983: Henner W D; Rodriguez L O; Hecht S M; Haseltine W A
gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.
The Journal of biological chemistry 1983;258(2):711-3.
1982: Nishikawa K; Hecht S M
A structurally modified yeast tRNAPhe with six nucleotides in the anticodon loop lacks significant phenylalanine acceptance.
The Journal of biological chemistry 1982;257(18):10536-9.
1982: Kross J; Henner W D; Hecht S M; Haseltine W A
Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin.
Biochemistry 1982;21(18):4310-8.
1982: Murugesan N; Ehrenfeld G M; Hecht S M
Oxygen transfer from bleomycin-metal complexes.
The Journal of biological chemistry 1982;257(15):8600-3.
1982: Kross J; Henner W D; Haseltine W A; Rodriguez L; Levin M D; Hecht S M
Structural basis for the deoxyribonucleic acid affinity of bleomycins.
Biochemistry 1982;21(15):3711-21.
1982: Rodriguez L O; Hecht S M
Iron(II)-bleomycin. Biochemical and spectral properties in the presence of radical scavengers.
Biochemical and biophysical research communications 1982;104(4):1470-6.
1982: Oppenheimer N J; Chang C; Chang L H; Ehrenfeld G; Rodriguez L O; Hecht S M
Deglyco-bleomycin. Degradation of DNA and formation of a structurally unique Fe(II) . CO complex.
The Journal of biological chemistry 1982;257(4):1606-9.
1981: Rupprecht K M; Sonenberg N; Shatkin A J; Hecht S M
Design and preparation of affinity columns for the purification of eukaryotic messenger ribonucleic acid cap binding protein.
Biochemistry 1981;20(23):6570-7.
1981: Pellón J R; Hecht S M; Gómez R F
[Effect of the antitumor antibiotic bleomycin on nuclear structure: sedimentation studies]
Revista española de fisiología 1981;37(3):363-4.
1981: Dell A; Morris H R; Levin M D; Hecht S M
Field desorption and fast atom bombardment mass spectrometry of bleomycins and their derivatives.
Biochemical and biophysical research communications 1981;102(2):730-8.
1981: Oppenheimer N J; Chang C; Rodriguez L O; Hecht S M
Copper(I) . bleomycin. A structurally unique oxidation-reduction active complex.
The Journal of biological chemistry 1981;256(4):1514-7.
1981: Pezzuto J M; Moore P D; Hecht S M
Metabolic activation of 1-methyl-3-amino-5H-pyrido[4,3-b]indole and several structurally related mutagens.
Biochemistry 1981;20(2):298-305.
1980: Dell A; Morris H R; Hecht S M; Levin M D
Characterisation of guanidino-containing antibiotics: field desorption mass spectrometry of bleomycin B2 and phleomycins D1 and E.
Biochemical and biophysical research communications 1980;97(3):987-94.
1980: Oppenheimer N J; Rodriguez L O; Hecht S M
Metal binding to modified bleomycins. Zinc and ferrous complexes with an acetylated bleomycin.
Biochemistry 1980;19(17):4096-103.
1980: Sonenberg N; Trachsel H; Hecht S; Shatkin A J
Differential stimulation of capped mRNA translation in vitro by cap binding protein.
Nature 1980;285(5763):331-3.
1980: Pezzuto J M; Lau P P; Luh Y; Moore P D; Wogan G N; Hecht S M
There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1427-31.
1980: Pezzuto J M; Hecht S M
Amino acid substitutions in protein biosynthesis. Poly(A)-directed polyphenylalanine synthesis.
The Journal of biological chemistry 1980;255(3):865-9.
1979: Oppenheimer N J; Rodriguez L O; Hecht S M
Structural studies of of "active complex" of bleomycin: assignment of ligands to the ferrous ion in a ferrous-bleomycin-carbon monoxide complex.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5616-20.
1979: Sonenberg N; Rupprecht K M; Hecht S M; Shatkin A J
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(9):4345-9.
1979: Alford B L; Pezzuto J M; Tan K H; Hecht S M
Both positional isomers of aminoacyl-tRNA's are bound by elongation factor Tu.
The Journal of biological chemistry 1979;254(15):6894-903.
1979: Alford B L; Hecht S M
Transfer RNA control of the activation of isomeric tRNATrp's.
The Journal of biological chemistry 1979;254(15):6873-5.
1979: Oppenheimer N J; Rodriguez L O; Hecht S M
Proton nuclear magnetic resonance study of the structure of bleomycin and the zinc-bleomycin complex.
Biochemistry 1979;18(16):3439-45.
1979: Alford B L; Chinault A C; Jolly S O; Hecht S M
Preparation of tRNAs terminating in 2'- and 3'- deoxyadenosine.
Methods in enzymology 1979;59():121-34.
1978: Arcari P; Hecht S M
Isoenergetic hydride transfer. A reversible tRNA modification with concomitant alteration of biochemical properties.
The Journal of biological chemistry 1978;253(22):8278-84.
1978: Alford B; Hecht S M
2'-Versus 3'-OH specificity in tRNA aminoacylation. Further support for the "secondary cognition" proposal.
The Journal of biological chemistry 1978;253(14):4844-50.
1978: Hecht S M; Alford B L; Kuroda Y; Kitano S
"Chemical aminoacylation" of tRNA's.
The Journal of biological chemistry 1978;253(13):4517-20.
1978: Adams B L; Morgan M; Muthukrishnan S; Hecht S M; Shatkin A J
The effect of "cap" analogs on reovirus mRNA binding to wheat germ ribosomes. Evidence for enhancement of ribosomal binding via a preferred cap conformation.
The Journal of biological chemistry 1978;253(8):2589-95.
1977: Hecht S M; Arcari P; Adams B L
Isoenergetic hydride transfer. A reversible, phase transition mediated tRNA modification.
Journal of the American Chemical Society 1977;99(11):3890-2.
1977: Hecht S M; Tan K H; Chinault A C; Arcari P
Isomeric aminoacyl-tRNAs are both bound by elongation factor Tu.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(2):437-41.
1977: Chinault A C; Tan K H; Hassur S M; Hecht S M
Initial position of aminoacylation of individual Escherichia coli, yeast, and calf liver transfer RNAs.
Biochemistry 1977;16(4):766-76.
1977: Chinault A C; Kozarich J W; Hecht S M; Schmidt F J; Bock R M
Preparation of Escherichia coli tRNAs terminating of modified nucleosides by the use of CTP(ATP):tRNA nucleotidyltransferase and polynucleotide phosphorylase.
Biochemistry 1977;16(4):756-65.
1976: Hecht S M; Adams B L; Kozarich J W
Chemical transformations of 7,9-disubstituted purines and related heterocycles. Selective reduction of imines and immonium salts.
The Journal of organic chemistry 1976;41(13):2303-11.
1976: Hecht S M; Frye R B; Werner D; Fukui T; Hawrelak S D
Synthesis and biological activity of pyrazolo[3,4,-d]pyrimidine nucleosides and nucleotides related to tubercidin, toyocamycin, and sangivamycin.
Biochemistry 1976;15(5):1005-15.
1976: Hecht S M; Chinualt A C
Position of aminoacylation of individual Escherichia coli and yeast tRNAs.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(2):405-9.
1975: Hecht S M; Frye R B; Werner D; Hawrelak S D; Skoog F; Schmitz R Y
On the "activation" of cytokinins.
The Journal of biological chemistry 1975;250(18):7343-51.
1975: Kozarich J W; Chinault A C; Hecht S M
Ribonucleoside 3'-di- and -triphosphates. Synthesis of guanosine tetraphosphate (ppGpp).
Biochemistry 1975;14(5):981-8.
1975: Hecht S M; Hawrelak S D
Hydrolysis of ribonucleoside 3'-diphosphates by rye grass 3'-nucleotidase.
Biochemistry 1975;14(5):974-81.
1974: Hecht S M; Faulkner R D; Hawrelak S D
Competitive inhibition of beef heart cyclic AMP phosphodiesterase by cytokinins and related compounds.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(12):4670-4.
1974: Hecht S M; Kozarich J W; Schmidt F J
Isomeric phenylalanyl-tRNAs. Position of the aminoacyl moiety during protein biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(11):4317-21.
1974: Hecht S M; Hawrelak S D
Interaction of glycyl-L-phenylalanine with Escherichia coli phenylalanyl-tRNA synthetase.
Biochemistry 1974;13(24):4967-75.
1973: Hecht S M; Kozarich J W
A chemical synthesis of adenosine 5'-(gamma-32P)triphosphate.
Biochimica et biophysica acta 1973;331(3):307-9.
1973: Kozarich J W; Chinault A C; Hecht S M
Ribonucleoside phosphates via phosphorimidazolidate intermediates. Synthesis of pseudoadenosine 5'-triphosphate.
Biochemistry 1973;12(22):4458-63.
1973: Hecht S M; Hawrelak S D; Kozarich J W; Schmidt F J; Bock R M
Chemical modifications of transfer RNA species. Transfer RNA's terminating in 2'- and 3'-O-methyladenosine.
Biochemical and biophysical research communications 1973;52(4):1341-7.
1973: Hecht S M; Werner D
A concise synthesis of substituted 4-alkylaminopyrazolo(3,40d)pyrimidines.
Journal of the Chemical Society. Perkin transactions 1 1973;17():1903-6.
1972: Gallo R C; Hecht S M; Whang-Peng J; O'Hopp S
N 6 -( 2 -Isopentenyl)adenosine: the regulatory effects of a cytokinin and modified nucleoside from tRNA on human lymphocytes.
Biochimica et biophysica acta 1972;281(4):488-500.
1972: Schmidt F J; Bock R M; Hecht S M
Chemical modifications of transfer rna species. Heavy atom derivatization of aminoacyl tRNA.
Biochemical and biophysical research communications 1972;48(2):451-6.
1972: Hecht S M; Sundaralingam M
Stereochemistry of of nucleic acids and their constituents. XXVI. The crystal and molecular structure of a 1:1 adduct of ethanol and 3'-deoxy-3'-(dihydroxyphosphinylmethyl)adenosine, an analog of adenosine 3'-monophosphate.
Journal of the American Chemical Society 1972;94(12):4314-9.
1972: Hecht S M; McDonald J J
Mass spectra of some 6-substituted ureidopurines and N 6 -acyladenines.
Analytical biochemistry 1972;47(1):157-73.
1971: Hecht S M
Mass spectra of some heterocycles related to N 6 -( 2 -isopentenyl)adenosine.
Analytical biochemistry 1971;44(1):262-75.
1971: Hecht S M; Bock R M; Schmitz R Y; Skoog F; Leonard N J; Occolowitz J L
Question of the ribosyl moiety in the promotion of callus growth by exogenously added cytokinins.
Biochemistry 1971;10(23):4224-8.
1971: Hecht S M; Bock R M; Schmitz R Y; Skoog F; Leonard N J
Cytokinins: development of a potent antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(10):2608-10.
1971: Hecht S M; Bock R M
Chemical modifications of transfer RNA species. Metal ion binding to monoperphthalate-treated tRNA.
Biochemical and biophysical research communications 1971;45(2):416-20.
1971: Hecht S M; Kirkegaard L H; Bock R M
Chemical modifications of transfer RNA species. Desulfurization with Raney nickel.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(1):48-51.
1970: Hecht S M; Gupta A S; Leonard N J
Mass spectra of ribonucleoside components of tRNA. II.
Analytical biochemistry 1970;38(1):230-51.
1970: Hecht S M; Bock R M; Leonard N J; Schmitz R Y
Cytokinin activity in tRNA-Phe.
Biochemical and biophysical research communications 1970;41(2):435-40.
1970: Hecht S M
Mass spectrometric identification of some prenylaminopurines.
Biochimica et biophysica acta 1970;213(2):269-72.
1970: Armstrong D J; Evans P K; Burrows W J; Skoog F; Petit J F; Dahl J L; Steward T; Strominger J L; Leonard N J; Hecht S M; Occolowitz J
Cytokinins. Activity and identification in Staphylococcus epidermidis transfer ribonucleic acid.
The Journal of biological chemistry 1970;245(11):2922-6.
1970: Burrows W J; Armstrong D J; Kaminek M; Skoog F; Bock R M; Hecht S M; Dammann L G; Leonard N J; Occolowitz J
Isolation and identification of four cytokinins from wheat germ transfer ribonucleic acid.
Biochemistry 1970;9(9):1867-72.
1969: Hecht S M; Leonard N J; Burrows W J; Armstrong D J; Skoog F; Occolowitz J
Cytokinin of wheat germ transfer RNA: 6-(4-hydroxy-3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuranosylpurine.
Science (New York, N.Y.) 1969;166(910):1272-4.
1969: Hecht S M; Gupta A S; Leonard N J
Mass spectra of nucleoside components of tRNA.
Analytical biochemistry 1969;30(2):249-70.
1969: Burrows W J; Armstrong D J; Skoog F; Hecht S M; Boyle J T; Leonard N J; Occolowitz J
The isolation and identification of two cytokinins from Escherichia coli transfer ribonucleic acids.
Biochemistry 1969;8(7):3071-6.
1969: Hecht S M; Gupta A S; Leonard N J
Position of uridine thiation: the identification of minor nucleosides from transfer RNA by mass spectrometry.
Biochimica et biophysica acta 1969;182(2):444-8.
1969: Hecht S M; Leonard N J
, Occolowitz J, Burrows WJ, Armstrong DJ, Skoog F, Bock RM, Gillam I, Tener GM: Cytokinins: isolation identification of 6-(3-methyl-2-butenylamino)-9-beta-D-ribyfuranosylpurine (2iPA) from yeast cysteine tRNA.
Biochemical and biophysical research communications 1969;35(2):205-9.
1968: Burrows W J; Armstrong D J; Skoog F; Hecht S M; Boyle J T; Leonard N J; Occolowitz J
Cytokinin from soluble RNA of Escherichia coli: 6-(3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuranosylpurine.
Science (New York, N.Y.) 1968;161(842):691-3.
1965: Brust D P; Tarbell D S; Hecht S M
STUDIES OF THE CYCLIZATIONS OF AN O-(alpha-METHYLALLYL)PHENOL AND THE CORRESPONDING METHYL ETHER INDUCED BY ELECTROPHILIC REAGENTS.
Proceedings of the National Academy of Sciences of the United States of America 1965;53(2):233-6.

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