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Sidney Hecht

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TOP 3
Rumit Maini; Dan T Nguyen; Rafael Alcala-Torano; Shengxi Chen; Sandipan Roy Chowdhury; Larisa M Dedkova; Sidney Hecht
Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center.
Omar M Khdour; Jun Lu; Sidney Hecht
An acetate prodrug of a pyridinol-based vitamin E analogue.
Ryan C Nangreave; Shengxi Chen; Larisa M Dedkova; Sidney Hecht
A new strategy for the synthesis of bisaminoacylated tRNAs.

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All Publications

2013: Rumit Maini; Dan T Nguyen; Rafael Alcala-Torano; Shengxi Chen; Sandipan Roy Chowdhury; Larisa M Dedkova; Sidney Hecht
Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center.
Bioorganic & medicinal chemistry 2013;21(5):1088-96.
2011: Omar M Khdour; Jun Lu; Sidney Hecht
An acetate prodrug of a pyridinol-based vitamin E analogue.
Pharmaceutical research 2011;28(11):2896-909.
2011: Ryan C Nangreave; Shengxi Chen; Larisa M Dedkova; Sidney Hecht
A new strategy for the synthesis of bisaminoacylated tRNAs.
Organic letters 2011;13(18):4906-9.
2011: Maria Duca; Carl O Trindle; Sidney Hecht
Structural basis for the exceptional stability of bisaminoacylated nucleotides and transfer RNAs.
Journal of the American Chemical Society 2011;133(29):11368-77.
2011: Xiaoqing Cai; Ali Cagir; Paul A Zaleski; Sidney Hecht
Deglycobleomycin A6 analogues modified in the methylvalerate moiety.
Bioorganic & medicinal chemistry 2011;19(12):3831-44.
2010: Rachel A Giroux; Sidney Hecht
Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs.
Journal of the American Chemical Society 2010;132(47):16987-96.
2010: Jun Lu; Xiaoqing Cai; Sidney Hecht
Concise synthesis of bicyclic pyridinol antioxidants.
Organic letters 2010;12(22):5189-91.
2010: Jun Lu; Omar M Khdour; Jeffrey S Armstrong; Sidney Hecht
Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant.
Bioorganic & medicinal chemistry 2010;18(21):7628-38.
2010: Damien Y Duveau; Pablo M Arce; Robert A Schoenfeld; Nidhi Raghav; Gino A Cortopassi; Sidney Hecht
Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria.
Bioorganic & medicinal chemistry 2010;18(17):6429-41.
2010: Jeffrey S Armstrong; Omar Khdour; Sidney Hecht
Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2152-63.
2010: Simon J Leiris; Omar M Khdour; Zachary J Segerman; Krystal S Tsosie; Jean-Charles Chapuis; Sidney Hecht
Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors.
Bioorganic & medicinal chemistry 2010;18(10):3481-93.
2009: Samantha Kendrick; Yoshitsugu Akiyama; Sidney Hecht; Laurence H Hurley
The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.
Journal of the American Chemical Society 2009;131(48):17667-76.
2009: Qasim A Khan; Jun Lu; Sidney Hecht
Calothrixins, a new class of human DNA topoisomerase I poisons.
Journal of natural products 2009;72(3):438-42.
2009: Sidney Hecht
Nucleic acids: expanding the structural and functional horizons.
Journal of the American Chemical Society 2009;131(11):3791-3.
2009: Jean-Charles Chapuis; Omar Khdour; Xiaoqing Cai; Jun Lu; Sidney Hecht
Synthesis and characterization of Deltalac-acetogenins that potently inhibit mitochondrial complex I.
Bioorganic & medicinal chemistry 2009;17(6):2204-9.
2009: Jean-Charles Chapuis; Ryan M Schmaltz; Krystal S Tsosie; Marek Belohlavek; Sidney Hecht
Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates.
Journal of the American Chemical Society 2009;131(7):2438-9.
2009: Qian Ma; Yoshitsugu Akiyama; Zhidong Xu; Kazuhide Konishi; Sidney Hecht
Identification and cleavage site analysis of DNA sequences bound strongly by bleomycin.
Journal of the American Chemical Society 2009;131(5):2013-22.
2008: Shengxi Chen; Sidney Hecht
Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine.
Bioorganic & medicinal chemistry 2008;16(19):9023-31.
2008: Qasim A Khan; Mark A Elban; Sidney Hecht
The topopyrones poison human DNA topoisomerases I and II.
Journal of the American Chemical Society 2008;130(39):12888-9.
2008: Maria Duca; Shengxi Chen; Sidney Hecht
Modeling the reactive properties of tandemly activated tRNAs.
Organic & biomolecular chemistry 2008;6(18):3292-9.
2008: Yoshitsugu Akiyama; Qian Ma; Erin Edgar; Andrei Laikhter; Sidney Hecht
Identification of strong DNA binding motifs for bleomycin.
Journal of the American Chemical Society 2008;130(30):9650-1.
2008: Lyudmila Yakovleva; Shengxi Chen; Sidney Hecht; Stewart Shuman
Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.
The Journal of biological chemistry 2008;283(23):16093-103.
2008: Yoshitsugu Akiyama; Qian Ma; Erin Edgar; Andrei Laikhter; Sidney Hecht
A novel DNA hairpin substrate for bleomycin.
Organic letters 2008;10(11):2127-30.
2008: Zhijie Gao; David J Maloney; Larisa M Dedkova; Sidney Hecht
Inhibitors of DNA polymerase beta: activity and mechanism.
Bioorganic & medicinal chemistry 2008;16(8):4331-40.
2008: Maria Duca; Shengxi Chen; Sidney Hecht
Aminoacylation of transfer RNAs with one and two amino acids.
Methods (San Diego, Calif.) 2008;44(2):87-99.
2008: Mark A Elban; Sidney Hecht
Total synthesis of the topopyrones: a new class of topoisomerase I poisons.
The Journal of organic chemistry 2008;73(3):785-93.
2007: Qian Ma; Zhidong Xu; Benjamin R Schroeder; Wenyue Sun; Fang Wei; Shigeki Hashimoto; Kazuhide Konishi; Christopher J Leitheiser; Sidney Hecht
Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties.
Journal of the American Chemical Society 2007;129(41):12439-52.
2007: David J Maloney; Noha Ghanem; Jia Zhou; Sidney Hecht
Positional assignment of differentially substituted bisaminoacylated pdCpAs.
Organic & biomolecular chemistry 2007;5(19):3135-8.
2007: Mark A Elban; Jean C Chapuis; Mei Li; Sidney Hecht
Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines.
Bioorganic & medicinal chemistry 2007;15(18):6119-25.
2007: Vladimir A Karginov; Ekaterina M Nestorovich; Frank Schmidtmann; Tanisha M Robinson; Adiamseged Yohannes; Nour Eddine Fahmi; Sergey M Bezrukov; Sidney Hecht
Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives.
Bioorganic & medicinal chemistry 2007;15(16):5424-31.
2007: jeffrey smith; David J Maloney; Sidney Hecht; Deborah A Lannigan
Structural basis for the activity of the RSK-specific inhibitor, SL0101.
Bioorganic & medicinal chemistry 2007;15(14):5018-34.
2007: Maria Duca; David J Maloney; Michiel Lodder; Bixun Wang; Sidney Hecht
Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs.
Bioorganic & medicinal chemistry 2007;15(13):4629-42.
2007: Ambar K Choudhury; Serguei Y Golovine; Larisa M Dedkova; Sidney Hecht
Synthesis of proteins containing modified arginine residues.
Biochemistry 2007;46(13):4066-76.
2007: Nour Eddine Fahmi; Larisa M Dedkova; Bixun Wang; Serguei Y Golovine; Sidney Hecht
Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins.
Journal of the American Chemical Society 2007;129(12):3586-97.
2007: George J Klarmann; Brian M Eisenhauer; Yi Zhang; Matthias Gotte; Janice D Pata; Deb K Chatterjee; Sidney Hecht; Stuart F J Le Grice
Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids.
Biochemistry 2007;46(8):2118-26.
2006: Larisa M Dedkova; Nour Eddine Fahmi; Serguei Y Golovine; Sidney Hecht
Construction of modified ribosomes for incorporation of D-amino acids into proteins.
Biochemistry 2006;45(51):15541-51.
2006: Zhi-Fu Tao; Kazuhide Konishi; Gérard Keith; Sidney Hecht
An efficient mammalian transfer RNA target for bleomycin.
Journal of the American Chemical Society 2006;128(46):14806-7.
2006: Vladimir A Karginov; Ekaterina M Nestorovich; Adiamseged Yohannes; Tanisha M Robinson; Nour Eddine Fahmi; Frank Schmidtmann; Sidney Hecht; Sergey M Bezrukov
Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities.
Antimicrobial agents and chemotherapy 2006;50(11):3740-53.
2006: Tam L Nguyen; Rick Gussio; jeffrey smith; Deborah A Lannigan; Sidney Hecht; Dominic A Scudiero; Robert H Shoemaker; Daniel W Zaharevitz
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.
Bioorganic & medicinal chemistry 2006;14(17):6097-105.
2006: jeffrey smith; David J Maloney; David E Clark; Yaming Xu; Sidney Hecht; Deborah A Lannigan
Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.
Bioorganic & medicinal chemistry 2006;14(17):6034-42.
2006: Mark A Elban; Wenyue Sun; Brian M Eisenhauer; Rong Gao; Sidney Hecht
Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin.
Organic letters 2006;8(16):3513-6.
2006: Rong Gao; Yi Zhang; Larisa M Dedkova; Ambar K Choudhury; Nicolas J Rahier; Sidney Hecht
Effects of modification of the active site tyrosine of human DNA topoisomerase I.
Biochemistry 2006;45(27):8402-10.
2006: Ya-ming Xu; jeffrey smith; Deborah A Lannigan; Sidney Hecht
Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.
Bioorganic & medicinal chemistry 2006;14(11):3974-7.
2006: Bixun Wang; Jia Zhou; Michiel Lodder; Raymond D Anderson; Sidney Hecht
Tandemly activated tRNAs as participants in protein synthesis.
The Journal of biological chemistry 2006;281(20):13865-8.
2006: David J Maloney; Shengxi Chen; Sidney Hecht
Stereoselective synthesis of the atropisomers of myristinin B/C.
Organic letters 2006;8(9):1925-7.
2006: Jason A Clement; Mei Li; Sidney Hecht; David G I Kingston
Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA.
Journal of natural products 2006;69(3):373-6.
2006: Paola B Arimondo; Craig J Thomas; Kahina Oussedik; Brigitte Baldeyrou; Christine Mahieu; Ludovic Halby; Dominique Guianvarc'h; Amélie Lansiaux; Sidney Hecht; Christian Bailly; Carine Giovannangeli
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates.
Molecular and cellular biology 2006;26(1):324-33.
2006: Vladimir A Karginov; Adiamseged Yohannes; Tanisha M Robinson; Nour Eddine Fahmi; Ken Alibek; Sidney Hecht
Beta-cyclodextrin derivatives that inhibit anthrax lethal toxin.
Bioorganic & medicinal chemistry 2006;14(1):33-40.
2005: Jing-Zhen Deng; Shelley R Starck; Shisheng Li; Sidney Hecht
(+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA.
Journal of natural products 2005;68(11):1625-8.
2005: Ikuo Nakanishi; Chiho Nishizawa; Kei Ohkubo; Keizo Takeshita; Kazuo T Suzuki; Toshihiko Ozawa; Sidney Hecht; Masayuki Tanno; Shoko Sueyoshi; Naoki Miyata; Haruhiro Okuda; Shunichi Fukuzumi; Nobuo Ikota; Kiyoshi Fukuhara
Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue.
Organic & biomolecular chemistry 2005;3(18):3263-5.
2005: David J Maloney; Sidney Hecht
A stereocontrolled synthesis of delta-trans-tocotrienoloic acid.
Organic letters 2005;7(19):4297-300.
2005: Van Cuong Pham; Ji Ma; Shannon J Thomas; Zhidong Xu; Sidney Hecht
Alkaloids from Alangium javanicum and Alangium grisolleoides that mediate Cu2+-dependent DNA strand scission.
Journal of natural products 2005;68(8):1147-52.
2005: Sidney Hecht
Camptothecin: roles of the D and E rings in binding to the topoisomerase I-DNA covalent binary complex.
Current medicinal chemistry. Anti-cancer agents 2005;5(4):353-62.
2005: Michiel Lodder; Bixun Wang; Sidney Hecht
The N-pentenoyl protecting group for aminoacyl-tRNAs.
Methods (San Diego, Calif.) 2005;36(3):245-51.
2005: Ligeng Tian; Christopher D Claeboe; Sidney Hecht; Stewart Shuman
Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine.
Structure (London, England : 1993) 2005;13(4):513-20.
2005: David J Maloney; Jing-Zhen Deng; Shelley R Starck; Zhijie Gao; Sidney Hecht
(+)-Myristinin A, a naturally occurring DNA polymerase beta inhibitor and potent DNA-damaging agent.
Journal of the American Chemical Society 2005;127(12):4140-1.
2005: Paola B Arimondo; Gary S Laco; Craig J Thomas; Ludovic Halby; Didier Pez; Philippe Schmitt; Alexandre S Boutorine; Thérèse Garestier; Yves Pommier; Sidney Hecht; Jian-Sheng Sun; Christian Bailly
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides.
Biochemistry 2005;44(11):4171-80.
2005: David J Maloney; Sidney Hecht
Synthesis of a potent and selective inhibitor of p90 Rsk.
Organic letters 2005;7(6):1097-9.
2005: Rong Gao; Yi Zhang; Ambar K Choudhury; Larisa M Dedkova; Sidney Hecht
Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine.
Journal of the American Chemical Society 2005;127(10):3321-31.
2005: Nicolas J Rahier; Kejun Cheng; Rong Gao; Brian M Eisenhauer; Sidney Hecht
Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison.
Organic letters 2005;7(5):835-7.
2005: Jing-Zhen Deng; David Newman; Sidney Hecht
Umbelactonyl cinnamate derivatives from Crypteronia paniculata that mediate DNA strand scission.
Journal of natural products 2005;68(3):465-7.
2005: Nicolas J Rahier; Brian M Eisenhauer; Rong Gao; Shannon J Thomas; Sidney Hecht
On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I-DNA covalent binary complex.
Bioorganic & medicinal chemistry 2005;13(4):1381-6.
2005: jeffrey smith; Celeste E Poteet-Smith; Yaming Xu; Timothy M Errington; Sidney Hecht; Deborah A Lannigan
Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.
Cancer research 2005;65(3):1027-34.
2005: Ji Ma; Shannon H Jones; Rebekah Marshall; Xihan Wu; Sidney Hecht
DNA topoisomerase I inhibitors from Rinorea anguifera.
Bioorganic & medicinal chemistry letters 2005;15(3):813-6.
2005: Ya-ming Xu; Randall K Johnson; Sidney Hecht
Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase.
Bioorganic & medicinal chemistry 2005;13(3):657-9.
2005: Kejun Cheng; Nicolas J Rahier; Brian M Eisenhauer; Rong Gao; Shannon J Thomas; Sidney Hecht
14-azacamptothecin: a potent water-soluble topoisomerase I poison.
Journal of the American Chemical Society 2005;127(3):838-9.
2005: Ji Ma; Shannon H Jones; Sidney Hecht
A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission.
Journal of natural products 2005;68(1):115-7.
2004: Ali Cagir; Brian M Eisenhauer; Rong Gao; Shannon J Thomas; Sidney Hecht
Synthesis and topoisomerase I inhibitory properties of luotonin A analogues.
Bioorganic & medicinal chemistry 2004;12(23):6287-99.
2004: V S Prakash Chaturvedula; Bing-Nan Zhou; Zhijie Gao; Shannon J Thomas; Sidney Hecht; David G I Kingston
New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta.
Bioorganic & medicinal chemistry 2004;12(23):6271-5.
2004: George J Klarmann; Brian M Eisenhauer; Yi Zhang; Kalavathy Sitaraman; Deb K Chatterjee; Sidney Hecht; Stuart F J Le Grice
Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase.
Protein expression and purification 2004;38(1):37-44.
2004: Xizhi Feng; Zhijie Gao; Shisheng Li; Shannon H Jones; Sidney Hecht
DNA polymerase beta lyase inhibitors from Maytenus putterlickoides.
Journal of natural products 2004;67(10):1744-7.
2004: Shugeng Cao; Zhijie Gao; Shannon J Thomas; Sidney Hecht; John Lazo; David G I Kingston
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
Journal of natural products 2004;67(10):1716-8.
2004: Hong-Yu Hu; Julie K Horton; Michael R Gryk; Rajendra Prasad; Jana M Naron; Di-An Sun; Sidney Hecht; Samuel H Wilson; Gregory P Mullen
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping.
The Journal of biological chemistry 2004;279(38):39736-44.
2004: Ji Ma; Shannon H Jones; Sidney Hecht
A coumarin from Mallotus resinosus that mediates DNA cleavage.
Journal of natural products 2004;67(9):1614-6.
2004: Shi-Sheng Li; Zhijie Gao; Xizhi Feng; Sidney Hecht
Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta.
Journal of natural products 2004;67(9):1608-10.
2004: Shi-Sheng Li; Zhijie Gao; Xizhi Feng; Shannon H Jones; Sidney Hecht
Plant sterols as selective DNA polymerase beta lyase inhibitors and potentiators of bleomycin cytotoxicity.
Bioorganic & medicinal chemistry 2004;12(15):4253-8.
2004: Ji Ma; Shannon H Jones; Sidney Hecht
Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum.
Bioorganic & medicinal chemistry 2004;12(14):3885-9.
2004: Ji Ma; Shannon H Jones; Rebekah Marshall; Randall K Johnson; Sidney Hecht
A DNA-damaging oxoaporphine alkaloid from Piper caninum.
Journal of natural products 2004;67(7):1162-4.
2004: VS Prakash Chaturvedula; Sidney Hecht; Zhijie Gao; Shannon H Jones; Xizhi Feng; David G I Kingston
New neolignans that inhibit DNA polymerase beta lyase.
Journal of natural products 2004;67(6):964-7.
2004: Rong Gao; Christopher D Claeboe; Brian M Eisenhauer; Sidney Hecht
Identification of specific nonbridging phosphate oxygens important for DNA cleavage by human topoisomerase I.
Biochemistry 2004;43(20):6167-81.
2004: Ji Ma; Sidney Hecht
Javaniside, a novel DNA cleavage agent from Alangium javanicum having an unusual oxindole skeleton.
Chemical communications (Cambridge, England) 2004;(10):1190-1.
2004: Ali Cagir; Shannon H Jones; Brian M Eisenhauer; Rong Gao; Sidney Hecht
Synthesis and biochemical properties of E-ring modified luotonin A derivatives.
Bioorganic & medicinal chemistry letters 2004;14(9):2051-4.
2004: V S Prakash Chaturvedula; Zhijie Gao; Shannon H Jones; Xizhi Feng; Sidney Hecht; David G I Kingston
A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase.
Journal of natural products 2004;67(5):899-901.
2004: Craig J Thomas; Nicolas J Rahier; Sidney Hecht
Camptothecin: current perspectives.
Bioorganic & medicinal chemistry 2004;12(7):1585-604.
2004: Nicolas J Rahier; Brian M Eisenhauer; Rong Gao; Shannon H Jones; Sidney Hecht
Water-soluble camptothecin derivatives that are intrinsic topoisomerase I poisons.
Organic letters 2004;6(3):321-4.
2004: Ligeng Tian; Christopher D Claeboe; Sidney Hecht; Stewart Shuman
Remote phosphate contacts trigger assembly of the active site of DNA topoisomerase IB.
Structure (London, England : 1993) 2004;12(1):31-40.
2003: Ali Cagir; Zhi-Fu Tao; Steven J Sucheck; Sidney Hecht
Solid-phase synthesis and biochemical evaluation of conformationally constrained analogues of deglycobleomycin A5.
Bioorganic & medicinal chemistry 2003;11(23):5179-87.
2003: Ali Cagir; Shannon H Jones; Rong Gao; Brian M Eisenhauer; Sidney Hecht
Luotonin A. A naturally occurring human DNA topoisomerase I poison.
Journal of the American Chemical Society 2003;125(45):13628-9.
2003: Christopher J Leitheiser; Sidney Hecht
Solid-phase synthesis of deglycobleomycin and bleomycin.
Current opinion in drug discovery & development 2003;6(6):827-37.
2003: VS Prakash Chaturvedula; Zhijie Gao; Sidney Hecht; Shannon H Jones; David G I Kingston
A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.
Journal of natural products 2003;66(11):1463-5.
2003: Christopher D Claeboe; Rong Gao; Sidney Hecht
3'-modified oligonucleotides by reverse DNA synthesis.
Nucleic acids research 2003;31(19):5685-91.
2003: Michael J Rishel; Craig J Thomas; Zhi-Fu Tao; Corine Vialas; Christopher J Leitheiser; Sidney Hecht
Conformationally constrained analogues of bleomycin A5.
Journal of the American Chemical Society 2003;125(34):10194-205.
2003: Christopher J Leitheiser; Kenneth Smith; Michael J Rishel; Shigeki Hashimoto; Kazuhide Konishi; Craig J Thomas; Chunhong Li; Michael M McCormick; Sidney Hecht
Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library.
Journal of the American Chemical Society 2003;125(27):8218-27.
2003: Ligeng Tian; Christopher D Claeboe; Sidney Hecht; Stewart Shuman
Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB.
Molecular cell 2003;12(1):199-208.
2003: Larisa M Dedkova; Nour Eddine Fahmi; Serguei Y Golovine; Sidney Hecht
Enhanced D-amino acid incorporation into protein by modified ribosomes.
Journal of the American Chemical Society 2003;125(22):6616-7.
2003: Ya-ming Xu; Jing-Zhen Deng; Ji Ma; Shao-Nong Chen; Rebekah Marshall; Shannon H Jones; Randall K Johnson; Sidney Hecht
DNA damaging activity of ellagic acid derivatives.
Bioorganic & medicinal chemistry 2003;11(7):1593-6.
2003: Anil T Abraham; Jih-Jing Lin; Dianne L Newton; Susanna M Rybak; Sidney Hecht
RNA cleavage and inhibition of protein synthesis by bleomycin.
Chemistry & biology 2003;10(1):45-52.
2002: Jing-Zhen Deng; Rebekah Marshall; Shannon H Jones; Randall K Johnson; Sidney Hecht
DNA-damaging agents from Crypteronia paniculata.
Journal of natural products 2002;65(12):1930-2.
2002: Craig J Thomas; Alexander O Chizhov; Christopher J Leitheiser; Michael J Rishel; Kazuhide Konishi; Zhi-Fu Tao; Sidney Hecht
Solid-phase synthesis of bleomycin A(5) and three monosaccharide analogues: exploring the role of the carbohydrate moiety in RNA cleavage.
Journal of the American Chemical Society 2002;124(44):12926-7.
2002: Brian M Eisenhauer; Sidney Hecht
Site-specific incorporation of (aminooxy)acetic acid into proteins.
Biochemistry 2002;41(38):11472-8.
2002: Raymond D Anderson; Jia Zhou; Sidney Hecht
Fluorescence resonance energy transfer between unnatural amino acids in a structurally modified dihydrofolate reductase.
Journal of the American Chemical Society 2002;124(33):9674-5.
2002: Ying Zou; Nour Eddine Fahmi; Corine Vialas; Guy M Miller; Sidney Hecht
Total synthesis of deamido bleomycin a(2), the major catabolite of the antitumor agent bleomycin.
Journal of the American Chemical Society 2002;124(32):9476-88.
2002: Zhi-Fu Tao; Christopher J Leitheiser; Kenneth Smith; Shigeki Hashimoto; Sidney Hecht
Solid-phase synthesis of deglycobleomycins: a C-terminal tetraamine linker that permits direct evaluation of resin-bound bleomycins.
Bioconjugate chemistry 2002;13(3):426-34.
2002: Craig J Thomas; Michael M McCormick; Corine Vialas; Zhi-Fu Tao; Christopher J Leitheiser; Michael J Rishel; Xihan Wu; Sidney Hecht
Alteration of the selectivity of DNA cleavage by a deglycobleomycin analogue containing a trithiazole moiety.
Journal of the American Chemical Society 2002;124(15):3875-84.
2002: Kenneth Smith; Zhi-Fu Tao; Shigeki Hashimoto; Christopher J Leitheiser; Xihan Wu; Sidney Hecht
Deglycobleomycin: solid-phase synthesis and DNA cleavage by the resin-bound ligand.
Organic letters 2002;4(7):1079-82.
2002: Bixun Wang; Kathlynn Brown; Michiel Lodder; Charles S Craik; Sidney Hecht
Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction.
Biochemistry 2002;41(8):2805-13.
2002: Paola B Arimondo; Alexandre S Boutorine; Brigitte Baldeyrou; Christian Bailly; Masayasu Kuwahara; Sidney Hecht; Jian-Sheng Sun; Thérèse Garestier; Claude Hélène
Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I.
The Journal of biological chemistry 2002;277(5):3132-40.
2001: M V Keck; R A Manderville; Sidney Hecht
Chemical and structural characterization of the interaction of bleomycin A2 with d(CGCGAATTCGCG)2. efficient, double-strand DNA cleavage accessible without structural reorganization.
Journal of the American Chemical Society 2001;123(36):8690-700.
2001: Michael J Rishel; Sidney Hecht
Analogues of bleomycin: synthesis of conformationally rigid methylvalerates.
Organic letters 2001;3(18):2867-9.
2001: M L Sznaidman; Sidney Hecht
Studies on the total synthesis of tallysomycin. Synthesis of the threonylbithiazole moiety containing a structurally unique glycosylcarbinolamide.
Organic letters 2001;3(18):2811-4.
2001: J C Quada; D Boturyn; Sidney Hecht
Photoactivated DNA cleavage by compounds structurally related to the bithiazole moiety of bleomycin.
Bioorganic & medicinal chemistry 2001;9(9):2303-14.
2001: Shigeki Hashimoto; Bixun Wang; Sidney Hecht
Kinetics of DNA cleavage by Fe(II).bleomycins.
Journal of the American Chemical Society 2001;123(30):7437-8.
2001: Berit Olsen Krogh; Christopher D Claeboe; Sidney Hecht; Stewart Shuman
Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase.
The Journal of biological chemistry 2001;276(24):20907-12.
2001: Anil T Abraham; X Zhou; Sidney Hecht
Metallobleomycin-mediated cleavage of DNA not involving a threading-intercalation mechanism.
Journal of the American Chemical Society 2001;123(22):5167-75.
2001: Ambar K Choudhury; Zhi-Fu Tao; Sidney Hecht
Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate.
Organic letters 2001;3(9):1291-4.
2001: Nour Eddine Fahmi; Serguei Y Golovine; Bixun Wang; Sidney Hecht
Studies toward the site specific incorporation of sugars into proteins: synthesis of glycosylated aminoacyl-tRNAs.
Carbohydrate research 2001;330(2):149-64.
2000: Christopher J Leitheiser; Michael J Rishel; Xihan Wu; Sidney Hecht
Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5).
Organic letters 2000;2(21):3397-9.
2000: Jing-Zhen Deng; Shelley R Starck; D A Sun; M Sabat; Sidney Hecht
A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta.
Journal of natural products 2000;63(10):1356-60.
2000: Bing-Nan Zhou; Jeannine M Hoch; Randall K Johnson; Michael R Mattern; W K Eng; J Ma; Sidney Hecht; David Newman; David G I Kingston
Use of COMPARE analysis to discover new natural product drugs: isolation of camptothecin and 9-methoxycamptothecin from a new source.
Journal of natural products 2000;63(9):1273-6.
2000: Jing-Zhen Deng; David Newman; Sidney Hecht
Use of COMPARE analysis to discover functional analogues of bleomycin.
Journal of natural products 2000;63(9):1269-72.
2000: GF Short; A L Laikhter; Michiel Lodder; Y Shayo; T Arslan; Sidney Hecht
Probing the S1/S1' substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues.
Biochemistry 2000;39(30):8768-81.
2000: Shelley R Starck; Jing-Zhen Deng; Sidney Hecht
Naturally occurring alkylresorcinols that mediate DNA damage and inhibit its repair.
Biochemistry 2000;39(9):2413-9.
2000: Bing-Nan Zhou; Randall K Johnson; Michael R Mattern; X Wang; Sidney Hecht; H T Beck; A Ortiz; David G I Kingston
Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon.
Journal of natural products 2000;63(2):217-21.
2000: Sidney Hecht
Camptothecins as probes of the microenvironments of topoisomerase I--DNA complexes.
Annals of the New York Academy of Sciences 2000;922():76-91.
2000: Jing-Zhen Deng; Shelley R Starck; Sidney Hecht
Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase beta.
Bioorganic & medicinal chemistry 2000;8(1):247-50.
2000: Sidney Hecht
Bleomycin: new perspectives on the mechanism of action.
Journal of natural products 2000;63(1):158-68.
1999: Ji Ma; Shelley R Starck; Sidney Hecht
DNA polymerase beta inhibitors from Tetracera boiviniana.
Journal of natural products 1999;62(12):1660-3.
1999: Jing-Zhen Deng; Shelley R Starck; Sidney Hecht
DNA polymerase beta inhibitors from Baeckea gunniana.
Journal of natural products 1999;62(12):1624-6.
1999: Andrei Karginov; Michiel Lodder; Sidney Hecht
Facile characterization of translation initiation via nonsense codon suppression.
Nucleic acids research 1999;27(16):3283-90.
1999: D A Sun; Shelley R Starck; E P Locke; Sidney Hecht
DNA polymerase beta inhibitors from Sandoricum koetjape.
Journal of natural products 1999;62(8):1110-3.
1999: GF Short; Serguei Y Golovine; Sidney Hecht
Effects of release factor 1 on in vitro protein translation and the elaboration of proteins containing unnatural amino acids.
Biochemistry 1999;38(27):8808-19.
1999: Jing-Zhen Deng; Shelley R Starck; Sidney Hecht; C F Ijames; M E Hemling
Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata.
Journal of natural products 1999;62(7):1000-2.
1999: X Wang; X Zhou; Sidney Hecht
Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex.
Biochemistry 1999;38(14):4374-81.
1999: Jing-Zhen Deng; Shelley R Starck; Sidney Hecht
bis-5-Alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase beta.
Journal of natural products 1999;62(3):477-80.
1998: X Wang; GF Short; W D Kingsbury; R K Johnson; Sidney Hecht
Effects of camptothecin analogues on DNA transformations mediated by calf thymus and human DNA topoisomerases I.
Chemical research in toxicology 1998;11(11):1352-60.
1998: X Wang; L K Wang; W D Kingsbury; R K Johnson; Sidney Hecht
Differential effects of camptothecin derivatives on topoisomerase I-mediated DNA structure modification.
Biochemistry 1998;37(26):9399-408.
1998: T Arslan; Anil T Abraham; Sidney Hecht
DNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation.
The Journal of biological chemistry 1998;273(20):12383-90.
1998: X Wang; K A Henningfeld; Sidney Hecht
DNA topoisomerase I-mediated formation of structurally modified DNA duplexes. Effects of metal ions and topoisomerase I inhibitors.
Biochemistry 1998;37(8):2691-700.
1998: T Arslan; Anil T Abraham; Sidney Hecht
Structurally altered substrates for DNA topoisomerase I. Effects of inclusion of a single 3'-deoxynucleotide within the scissile strand.
Nucleosides & nucleotides 1998;17(1-3):515-30.
1997: V A Karginov; S V Mamaev; Sidney Hecht
In vitro suppression as a tool for the investigation of translation initiation.
Nucleic acids research 1997;25(19):3912-6.
1997: Chris E Holmes; R J Duff; G A van der Marel; J van Boom; Sidney Hecht
On the chemistry of RNA degradation by Fe.bleomycin.
Bioorganic & medicinal chemistry 1997;5(6):1235-48.
1996: Chris E Holmes; Anil T Abraham; Sidney Hecht; C Florentz; Richard Giegé
Fe.bleomycin as a probe of RNA conformation.
Nucleic acids research 1996;24(17):3399-406.
1996: L K Wang; B D Rogers; Sidney Hecht
Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne.
Chemical research in toxicology 1996;9(1):75-83.
1995: S A Kane; Sidney Hecht; J S Sun; T Garestier; C Hélène
Specific cleavage of a DNA triple helix by FeII.bleomycin.
Biochemistry 1995;34(51):16715-24.
1995: M A Morgan; S A Kazakov; Sidney Hecht
Phosphoryl migration during the chemical synthesis of RNA.
Nucleic acids research 1995;23(19):3949-53.
1995: M V Keck; Sidney Hecht
Sequence-specific hydrolysis of yeast tRNA(Phe) mediated by metal-free bleomycin.
Biochemistry 1995;34(37):12029-37.
1995: K A Henningfeld; Sidney Hecht
A model for topoisomerase I-mediated insertions and deletions with duplex DNA substrates containing branches, nicks, and gaps.
Biochemistry 1995;34(18):6120-9.
1994: Sidney Hecht
RNA degradation by bleomycin, a naturally occurring bioconjugate.
Bioconjugate chemistry 1994;5(6):513-26.
1994: M A Morgan; Sidney Hecht
Iron(II) bleomycin-mediated degradation of a DNA-RNA heteroduplex.
Biochemistry 1994;33(34):10286-93.
1994: S A Kane; A Natrajan; Sidney Hecht
On the role of the bithiazole moiety in sequence-selective DNA cleavage by Fe.bleomycin.
The Journal of biological chemistry 1994;269(14):10899-904.
1994: S A Kane; Sidney Hecht
Polynucleotide recognition and degradation by bleomycin.
Progress in nucleic acid research and molecular biology 1994;49():313-52.
1994: R B Van Atta; Sidney Hecht
A ribozyme model: site-specific cleavage of an RNA substrate by Mn2+.
Advances in inorganic biochemistry 1994;9():1-40.
1993: Chris E Holmes; Sidney Hecht
Fe.bleomycin cleaves a transfer RNA precursor and its "transfer DNA" analog at the same major site.
The Journal of biological chemistry 1993;268(34):25909-13.
1993: L K Wang; Randall K Johnson; Sidney Hecht
Inhibition of topoisomerase I function by nitidine and fagaronine.
Chemical research in toxicology 1993;6(6):813-8.
1993: Chris E Holmes; B J Carter; Sidney Hecht
Characterization of iron (II).bleomycin-mediated RNA strand scission.
Biochemistry 1993;32(16):4293-307.
1992: E Resto; A Iida; M D Van Cleve; Sidney Hecht
Amplification of protein expression in a cell free system.
Nucleic acids research 1992;20(22):5979-83.
1992: Sidney Hecht; D E Berry; L J MacKenzie; R W Busby; C A Nasuti
A strategy for identifying novel, mechanistically unique inhibitors of topoisomerase I.
Journal of natural products 1992;55(4):401-13.
1991: K Nagai; Sidney Hecht
Site-specific DNA cleavage by antisense oligonucleotides covalently linked to phenazine di-N-oxide.
The Journal of biological chemistry 1991;266(35):23994-4002.
1991: D E Berry; J A Chan; L MacKenzie; Sidney Hecht
9-Octadecynoic acid: a novel DNA binding agent.
Chemical research in toxicology 1991;4(2):195-8.
1991: W D Kingsbury; Jeffrey C Boehm; Dalia R Jakas; K G Holden; Sidney Hecht; G Gallagher; M J Caranfa; F L McCabe; L F Faucette; Randall K Johnson
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Journal of medicinal chemistry 1991;34(1):98-107.
1990: C K Surratt; B J Carter; R C Payne; Sidney Hecht
Metal ion and substrate structure dependence of the processing of tRNA precursors by RNase P and M1 RNA.
The Journal of biological chemistry 1990;265(36):22513-9.
1990: C K Surratt; Z Lesnikowski; A L Schifman; F J Schmidt; Sidney Hecht
Construction and processing of transfer RNA precursor models.
The Journal of biological chemistry 1990;265(36):22506-12.
1990: B J Carter; E de Vroom; E C Long; G A van der Marel; J H van Boom; Sidney Hecht
Site-specific cleavage of RNA by Fe(II).bleomycin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9373-7.
1990: R P Hertzberg; R W Busby; M J Caranfa; K G Holden; Randall K Johnson; Sidney Hecht; W D Kingsbury
Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site.
The Journal of biological chemistry 1990;265(31):19287-95.
1990: R B Van Atta; J Bernadou; Bernard MEUNIER; Sidney Hecht
On the chemical nature of DNA and RNA modification by a hemin model system.
Biochemistry 1990;29(20):4783-9.
1990: B J Carter; B S Vold; Sidney Hecht
Control of the position of RNase P-mediated transfer RNA precursor processing.
The Journal of biological chemistry 1990;265(13):7100-3.
1990: V Dange; R B Van Atta; Sidney Hecht
A Mn2(+)-dependent ribozyme.
Science (New York, N.Y.) 1990;248(4955):585-8.
1990: B J Carter; V S Murty; K S Reddy; S N Wang; Sidney Hecht
A role for the metal binding domain in determining the DNA sequence selectivity of Fe-bleomycin.
The Journal of biological chemistry 1990;265(8):4193-6.
1989: J R Roesser; C Xu; R C Payne; C K Surratt; Sidney Hecht
Preparation of misacylated aminoacyl-tRNA(Phe)'s useful as probes of the ribosomal acceptor site.
Biochemistry 1989;28(12):5185-95.
1989: R P Hertzberg; M J Caranfa; Sidney Hecht
On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex.
Biochemistry 1989;28(11):4629-38.
1989: Said M Sebti; J C DeLeon; L T Ma; Sidney Hecht; John Lazo
Substrate specificity of bleomycin hydrolase.
Biochemical pharmacology 1989;38(1):141-7.
1988: A Jäger; M J Levy; Sidney Hecht
Oligonucleotide N-alkylphosphoramidates: synthesis and binding to polynucleotides.
Biochemistry 1988;27(19):7237-46.
1988: T G Heckler; J R Roesser; C Xu; P I Chang; Sidney Hecht
Ribosomal binding and dipeptide formation by misacylated tRNA(Phe),S.
Biochemistry 1988;27(19):7254-62.
1988: J R Barr; V S Murty; K Yamaguchi; S Singh; D H Smith; Sidney Hecht
5-Alkylresorcinols from Hakea amplexicaulis that cleave DNA.
Chemical research in toxicology 1988;1(4):204-7.
1988: R P Hertzberg; M J Caranfa; Sidney Hecht
Degradation of structurally modified DNAs by bleomycin group antibiotics.
Biochemistry 1988;27(9):3164-74.
1988: M J Levy; Sidney Hecht
Copper(II) facilitates bleomycin-mediated unwinding of plasmid DNA.
Biochemistry 1988;27(8):2647-50.
1988: H Sugiyama; C Xu; N Murugesan; Sidney Hecht; G A van der Marel; J H van Boom
Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG).
Biochemistry 1988;27(1):58-67.
1988: J B Shipley; Sidney Hecht
Bleomycin congeners exhibiting altered DNA cleavage specificity.
Chemical research in toxicology 1988;1(1):25-7.
1987: R C Payne; B P Nichols; Sidney Hecht
Escherichia coli tryptophan synthase: synthesis of catalytically competent alpha subunit in a cell-free system containing preacylated tRNAs.
Biochemistry 1987;26(11):3197-205.
1987: G M Ehrenfeld; J B Shipley; D C Heimbrook; Hiroshi Sugiyama; E C Long; J H van Boom; G A van der Marel; N J Oppenheimer; Sidney Hecht
Copper-dependent cleavage of DNA by bleomycin.
Biochemistry 1987;26(3):931-42.
1986: Sidney Hecht
DNA strand scission by activated bleomycin group antibiotics.
Federation proceedings 1986;45(12):2784-91.
1986: J R Roesser; M S Chorghade; Sidney Hecht
Ribosome-catalyzed formation of an abnormal peptide analogue.
Biochemistry 1986;25(21):6361-5.
1986: R P Hertzberg; Sidney Hecht; V L Reynolds; I J Molineux; Laurence H Hurley
DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs.
Biochemistry 1986;25(6):1249-58.
1986: Hiroshi Sugiyama; T Morii; I Saito; T Matsuura; Sidney Hecht
Structure and chemistry of alkali-labile product formed during Fe(II)-bleomycin-mediated DNA strand scission.
Nucleic acids symposium series 1986;(17):165-6.
1985: Y H Hsiang; R Hertzberg; Sidney Hecht; L F Liu
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
The Journal of biological chemistry 1985;260(27):14873-8.
1985: Hiroshi Sugiyama; G M Ehrenfeld; J B Shipley; R E Kilkuskie; L H Chang; Sidney Hecht
DNA strand scission by bleomycin group antibiotics.
Journal of natural products 1985;48(6):869-77.
1985: N Murugesan; C Xu; G M Ehrenfeld; Hiroshi Sugiyama; R E Kilkuskie; L O Rodriguez; L H Chang; Sidney Hecht
Analysis of products formed during bleomycin-mediated DNA degradation.
Biochemistry 1985;24(21):5735-44.
1985: R P Hertzberg; M J Caranfa; Sidney Hecht
DNA methylation diminishes bleomycin-mediated strand scission.
Biochemistry 1985;24(20):5286-9.
1985: D E Berry; R E Kilkuskie; Sidney Hecht
DNA damage induced by bleomycin in the presence of dibucaine is not predictive of cell growth inhibition.
Biochemistry 1985;24(13):3214-9.
1985: D E Berry; L H Chang; Sidney Hecht
DNA damage and growth inhibition in cultured human cells by bleomycin congeners.
Biochemistry 1985;24(13):3207-14.
1985: Chun-Tao Che; X D Fang; C H Phoebe; A D Kinghorn; Norman R Farnsworth; B Yellin; Sidney Hecht
High-field 1H-NMR spectral analysis of some cucurbitacins.
Journal of natural products 1985;48(3):429-34.
1985: G M Ehrenfeld; L O Rodriguez; Sidney Hecht; C Chang; V J Basus; N J Oppenheimer
Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission.
Biochemistry 1985;24(1):81-92.
1984: R E Kilkuskie; T L Macdonald; Sidney Hecht
Bleomycin may be activated for DNA cleavage by NADPH-cytochrome P-450 reductase.
Biochemistry 1984;23(25):6165-71.
1984: X Fang; C H Phoebe; J M Pezzuto; Harry H S Fong; Norman R Farnsworth; B Yellin; Sidney Hecht
Plant anticancer agents, XXXIV. Cucurbitacins from Elaeocarpus dolichostylus.
Journal of natural products 1984;47(6):988-93.
1984: T G Heckler; L H Chang; Y Zama; T Naka; M S Chorghade; Sidney Hecht
T4 RNA ligase mediated preparation of novel "chemically misacylated" tRNAPheS.
Biochemistry 1984;23(7):1468-73.
1983: G M Ehrenfeld; T A Francis; Sidney Hecht
Loss of positional specificity in the aminoacylation of Escherichia coli tRNAGly.
The Journal of biological chemistry 1983;258(19):11745-50.
1983: T G Heckler; Y Zama; T Naka; Sidney Hecht
Dipeptide formation with misacylated tRNAPhes.
The Journal of biological chemistry 1983;258(7):4492-5.
1983: T A Francis; G M Ehrenfeld; M R Gregory; Sidney Hecht
Transfer RNA pyrophosphorolysis with CTP(ATP):tRNA nucleotidyltransferase. A direct route to tRNAs modified at the 3' terminus.
The Journal of biological chemistry 1983;258(7):4279-84.
1983: J R Pellon; A J Sinskey; Sidney Hecht; R F Gomez
Kinetics of the bleomycin A2 damage in vivo to the folded chromosome of Escherichia coli.
Chemico-biological interactions 1983;43(2):245-51.
1983: W D Henner; L O Rodriguez; Sidney Hecht; W A Haseltine
gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.
The Journal of biological chemistry 1983;258(2):711-3.
1982: K Nishikawa; Sidney Hecht
A structurally modified yeast tRNAPhe with six nucleotides in the anticodon loop lacks significant phenylalanine acceptance.
The Journal of biological chemistry 1982;257(18):10536-9.
1982: J Kross; W D Henner; Sidney Hecht; W A Haseltine
Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin.
Biochemistry 1982;21(18):4310-8.
1982: N Murugesan; G M Ehrenfeld; Sidney Hecht
Oxygen transfer from bleomycin-metal complexes.
The Journal of biological chemistry 1982;257(15):8600-3.
1982: J Kross; W D Henner; W A Haseltine; L Rodriguez; M D Levin; Sidney Hecht
Structural basis for the deoxyribonucleic acid affinity of bleomycins.
Biochemistry 1982;21(15):3711-21.
1982: L O Rodriguez; Sidney Hecht
Iron(II)-bleomycin. Biochemical and spectral properties in the presence of radical scavengers.
Biochemical and biophysical research communications 1982;104(4):1470-6.
1982: N J Oppenheimer; C Chang; L H Chang; G Ehrenfeld; L O Rodriguez; Sidney Hecht
Deglyco-bleomycin. Degradation of DNA and formation of a structurally unique Fe(II) . CO complex.
The Journal of biological chemistry 1982;257(4):1606-9.
1981: K M Rupprecht; N Sonenberg; A J Shatkin; Sidney Hecht
Design and preparation of affinity columns for the purification of eukaryotic messenger ribonucleic acid cap binding protein.
Biochemistry 1981;20(23):6570-7.
1981: A Dell; H R Morris; M D Levin; Sidney Hecht
Field desorption and fast atom bombardment mass spectrometry of bleomycins and their derivatives.
Biochemical and biophysical research communications 1981;102(2):730-8.
1981: J R Pellón; Sidney Hecht; R F Gómez
[Effect of the antitumor antibiotic bleomycin on nuclear structure: sedimentation studies].
Revista española de fisiología 1981;37(3):363-4.
1981: N J Oppenheimer; C Chang; L O Rodriguez; Sidney Hecht
Copper(I) . bleomycin. A structurally unique oxidation-reduction active complex.
The Journal of biological chemistry 1981;256(4):1514-7.
1981: J M Pezzuto; P D Moore; Sidney Hecht
Metabolic activation of 1-methyl-3-amino-5H-pyrido[4,3-b]indole and several structurally related mutagens.
Biochemistry 1981;20(2):298-305.
1980: A Dell; H R Morris; Sidney Hecht; M D Levin
Characterisation of guanidino-containing antibiotics: field desorption mass spectrometry of bleomycin B2 and phleomycins D1 and E.
Biochemical and biophysical research communications 1980;97(3):987-94.
1980: N J Oppenheimer; L O Rodriguez; Sidney Hecht
Metal binding to modified bleomycins. Zinc and ferrous complexes with an acetylated bleomycin.
Biochemistry 1980;19(17):4096-103.
1980: N Sonenberg; H Trachsel; Sidney Hecht; A J Shatkin
Differential stimulation of capped mRNA translation in vitro by cap binding protein.
Nature 1980;285(5763):331-3.
1980: J M Pezzuto; Paul Lau; Y Luh; P D Moore; G N Wogan; Sidney Hecht
There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1427-31.
1980: J M Pezzuto; Sidney Hecht
Amino acid substitutions in protein biosynthesis. Poly(A)-directed polyphenylalanine synthesis.
The Journal of biological chemistry 1980;255(3):865-9.
1979: N J Oppenheimer; L O Rodriguez; Sidney Hecht
Structural studies of of "active complex" of bleomycin: assignment of ligands to the ferrous ion in a ferrous-bleomycin-carbon monoxide complex.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5616-20.
1979: N Sonenberg; K M Rupprecht; Sidney Hecht; A J Shatkin
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(9):4345-9.
1979: B L Alford; J M Pezzuto; K H Tan; Sidney Hecht
Both positional isomers of aminoacyl-tRNA's are bound by elongation factor Tu.
The Journal of biological chemistry 1979;254(15):6894-903.
1979: B L Alford; Sidney Hecht
Transfer RNA control of the activation of isomeric tRNATrp's.
The Journal of biological chemistry 1979;254(15):6873-5.
1979: N J Oppenheimer; L O Rodriguez; Sidney Hecht
Proton nuclear magnetic resonance study of the structure of bleomycin and the zinc-bleomycin complex.
Biochemistry 1979;18(16):3439-45.
1979: B L Alford; A C Chinault; S O Jolly; Sidney Hecht
Preparation of tRNAs terminating in 2'- and 3'- deoxyadenosine.
Methods in enzymology 1979;59():121-34.
1978: P Arcari; Sidney Hecht
Isoenergetic hydride transfer. A reversible tRNA modification with concomitant alteration of biochemical properties.
The Journal of biological chemistry 1978;253(22):8278-84.
1978: B Alford; Sidney Hecht
2'-Versus 3'-OH specificity in tRNA aminoacylation. Further support for the "secondary cognition" proposal.
The Journal of biological chemistry 1978;253(14):4844-50.
1978: Sidney Hecht; B L Alford; Y Kuroda; S Kitano
"Chemical aminoacylation" of tRNA's.
The Journal of biological chemistry 1978;253(13):4517-20.
1978: B L Adams; M Morgan; S Muthukrishnan; Sidney Hecht; A J Shatkin
The effect of "cap" analogs on reovirus mRNA binding to wheat germ ribosomes. Evidence for enhancement of ribosomal binding via a preferred cap conformation.
The Journal of biological chemistry 1978;253(8):2589-95.
1977: Sidney Hecht; P Arcari; B L Adams
Isoenergetic hydride transfer. A reversible, phase transition mediated tRNA modification.
Journal of the American Chemical Society 1977;99(11):3890-2.
1977: A C Chinault; K H Tan; S M Hassur; Sidney Hecht
Initial position of aminoacylation of individual Escherichia coli, yeast, and calf liver transfer RNAs.
Biochemistry 1977;16(4):766-76.
1977: A C Chinault; J W Kozarich; Sidney Hecht; F J Schmidt; R M Bock
Preparation of Escherichia coli tRNAs terminating of modified nucleosides by the use of CTP(ATP):tRNA nucleotidyltransferase and polynucleotide phosphorylase.
Biochemistry 1977;16(4):756-65.
1977: Sidney Hecht; K H Tan; A C Chinault; P Arcari
Isomeric aminoacyl-tRNAs are both bound by elongation factor Tu.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(2):437-41.
1976: Sidney Hecht; B L Adams; J W Kozarich
Chemical transformations of 7,9-disubstituted purines and related heterocycles. Selective reduction of imines and immonium salts.
The Journal of organic chemistry 1976;41(13):2303-11.
1976: Sidney Hecht; R B Frye; D Werner; T Fukui; S D Hawrelak
Synthesis and biological activity of pyrazolo[3,4,-d]pyrimidine nucleosides and nucleotides related to tubercidin, toyocamycin, and sangivamycin.
Biochemistry 1976;15(5):1005-15.
1976: Sidney Hecht; A C Chinualt
Position of aminoacylation of individual Escherichia coli and yeast tRNAs.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(2):405-9.
1975: Sidney Hecht; R B Frye; D Werner; S D Hawrelak; F Skoog; R Y Schmitz
On the "activation" of cytokinins.
The Journal of biological chemistry 1975;250(18):7343-51.
1975: F Skoog; R Y Schmitz; Sidney Hecht; R B Frye
Anticytokinin activity of substituted pyrrolo[2,3-d]pyrimidines.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(9):3508-12.
1975: J W Kozarich; A C Chinault; Sidney Hecht
Ribonucleoside 3'-di- and -triphosphates. Synthesis of guanosine tetraphosphate (ppGpp).
Biochemistry 1975;14(5):981-8.
1975: Sidney Hecht; S D Hawrelak
Hydrolysis of ribonucleoside 3'-diphosphates by rye grass 3'-nucleotidase.
Biochemistry 1975;14(5):974-81.
1974: Sidney Hecht; R D Faulkner; S D Hawrelak
Competitive inhibition of beef heart cyclic AMP phosphodiesterase by cytokinins and related compounds.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(12):4670-4.
1974: Sidney Hecht; S D Hawrelak
Interaction of glycyl-L-phenylalanine with Escherichia coli phenylalanyl-tRNA synthetase.
Biochemistry 1974;13(24):4967-75.
1974: Sidney Hecht; J W Kozarich; F J Schmidt
Isomeric phenylalanyl-tRNAs. Position of the aminoacyl moiety during protein biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(11):4317-21.
1973: Sidney Hecht; J W Kozarich
A chemical synthesis of adenosine 5'-(gamma-32P)triphosphate.
Biochimica et biophysica acta 1973;331(3):307-9.
1973: J W Kozarich; A C Chinault; Sidney Hecht
Ribonucleoside phosphates via phosphorimidazolidate intermediates. Synthesis of pseudoadenosine 5'-triphosphate.
Biochemistry 1973;12(22):4458-63.
1973: Sidney Hecht; S D Hawrelak; J W Kozarich; F J Schmidt; R M Bock
Chemical modifications of transfer RNA species. Transfer RNA's terminating in 2'- and 3'-O-methyladenosine.
Biochemical and biophysical research communications 1973;52(4):1341-7.
1973: Sidney Hecht; D Werner
A concise synthesis of substituted 4-alkylaminopyrazolo(3,40d)pyrimidines.
Journal of the Chemical Society. Perkin transactions 1 1973;17():1903-6.
1972: Robert C Gallo; Sidney Hecht; J Whang-Peng; S O'Hopp
N 6 -( 2 -Isopentenyl)adenosine: the regulatory effects of a cytokinin and modified nucleoside from tRNA on human lymphocytes.
Biochimica et biophysica acta 1972;281(4):488-500.
1972: F J Schmidt; R M Bock; Sidney Hecht
Chemical modifications of transfer rna species. Heavy atom derivatization of aminoacyl tRNA.
Biochemical and biophysical research communications 1972;48(2):451-6.
1972: Sidney Hecht; M Sundaralingam
Stereochemistry of of nucleic acids and their constituents. XXVI. The crystal and molecular structure of a 1:1 adduct of ethanol and 3'-deoxy-3'-(dihydroxyphosphinylmethyl)adenosine, an analog of adenosine 3'-monophosphate.
Journal of the American Chemical Society 1972;94(12):4314-9.
1972: Sidney Hecht; J J McDonald
Mass spectra of some 6-substituted ureidopurines and N 6 -acyladenines.
Analytical biochemistry 1972;47(1):157-73.
1971: Sidney Hecht
Mass spectra of some heterocycles related to N 6 -( 2 -isopentenyl)adenosine.
Analytical biochemistry 1971;44(1):262-75.
1971: Sidney Hecht; R M Bock; R Y Schmitz; F Skoog; N J Leonard; J L Occolowitz
Question of the ribosyl moiety in the promotion of callus growth by exogenously added cytokinins.
Biochemistry 1971;10(23):4224-8.
1971: Sidney Hecht; R M Bock
Chemical modifications of transfer RNA species. Metal ion binding to monoperphthalate-treated tRNA.
Biochemical and biophysical research communications 1971;45(2):416-20.
1971: Sidney Hecht; R M Bock; R Y Schmitz; F Skoog; N J Leonard
Cytokinins: development of a potent antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(10):2608-10.
1971: Sidney Hecht; L H Kirkegaard; R M Bock
Chemical modifications of transfer RNA species. Desulfurization with Raney nickel.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(1):48-51.
1970: Sidney Hecht; A S Gupta; N J Leonard
Mass spectra of ribonucleoside components of tRNA. II.
Analytical biochemistry 1970;38(1):230-51.
1970: Sidney Hecht; R M Bock; N J Leonard; R Y Schmitz
Cytokinin activity in tRNA-Phe.
Biochemical and biophysical research communications 1970;41(2):435-40.
1970: Sidney Hecht
Mass spectrometric identification of some prenylaminopurines.
Biochimica et biophysica acta 1970;213(2):269-72.
1970: D J Armstrong; P K Evans; W J Burrows; F Skoog; J F Petit; J L Dahl; T Steward; J L Strominger; N J Leonard; Sidney Hecht; J Occolowitz
Cytokinins. Activity and identification in Staphylococcus epidermidis transfer ribonucleic acid.
The Journal of biological chemistry 1970;245(11):2922-6.
1970: W J Burrows; D J Armstrong; M Kaminek; F Skoog; R M Bock; Sidney Hecht; L G Dammann; N J Leonard; J Occolowitz
Isolation and identification of four cytokinins from wheat germ transfer ribonucleic acid.
Biochemistry 1970;9(9):1867-72.
1969: Sidney Hecht; N J Leonard; W J Burrows; D J Armstrong; F Skoog; J Occolowitz
Cytokinin of wheat germ transfer RNA: 6-(4-hydroxy-3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuranosylpurine.
Science (New York, N.Y.) 1969;166(3910):1272-4.
1969: Sidney Hecht; A S Gupta; N J Leonard
Mass spectra of nucleoside components of tRNA.
Analytical biochemistry 1969;30(2):249-70.
1969: W J Burrows; D J Armstrong; F Skoog; Sidney Hecht; J T Boyle; N J Leonard; J Occolowitz
The isolation and identification of two cytokinins from Escherichia coli transfer ribonucleic acids.
Biochemistry 1969;8(7):3071-6.
1969: Sidney Hecht; A S Gupta; N J Leonard
Position of uridine thiation: the identification of minor nucleosides from transfer RNA by mass spectrometry.
Biochimica et biophysica acta 1969;182(2):444-8.
1969: N J Leonard; Sidney Hecht; F Skoog; R Y Schmitz
Cytokinins: synthesis, mass spectra, and biological activity of compounds related to zeatin.
Proceedings of the National Academy of Sciences of the United States of America 1969;63(1):175-82.
1969: Sidney Hecht; N J Leonard
, Occolowitz J, Burrows WJ, Armstrong DJ, Skoog F, Bock RM, Gillam I, Tener GM: Cytokinins: isolation identification of 6-(3-methyl-2-butenylamino)-9-beta-D-ribyfuranosylpurine (2iPA) from yeast cysteine tRNA.
Biochemical and biophysical research communications 1969;35(2):205-9.
1968: W J Burrows; D J Armstrong; F Skoog; Sidney Hecht; J T Boyle; N J Leonard; J Occolowitz
Cytokinin from soluble RNA of Escherichia coli: 6-(3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuranosylpurine.
Science (New York, N.Y.) 1968;161(3842):691-3.
1968: N J Leonard; Sidney Hecht; F Skoog; R Y Schmitz
CYTOKININS: SYNTHESIS OF 6-(3-METHYL-3-BUTENYLAMINO)-9-beta-D-RIBOFURANOSYLPURINE (3IPA), AND THE EFFECT OF SIDE-CHAIN UNSATURATION ON THE BIOLOGICAL ACTIVITY OF ISOPENTYLAMINOPURINES AND THEIR RIBOSIDES.
Proceedings of the National Academy of Sciences of the United States of America 1968;59(1):15-21.
1965: D P Brust; D S Tarbell; Sidney Hecht
STUDIES OF THE CYCLIZATIONS OF AN O-(alpha-METHYLALLYL)PHENOL AND THE CORRESPONDING METHYL ETHER INDUCED BY ELECTROPHILIC REAGENTS.
Proceedings of the National Academy of Sciences of the United States of America 1965;53(2):233-6.