FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Howard Federoff

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Procedures

Devices

Gene Transfer Techniques

Disorders

Physiology

Co-author Network

Publications

TOP 3
Amanda Dudak; Jinsook Kim; Bryan Cheong; Howard Federoff; Seung T Lim
Membrane palmitoylated proteins regulate trafficking and processing of nectins.
Salim Shah; Howard Federoff
Therapeutic potential of vaccines for Alzheimer's disease.
Polyxeni Philippidou; Gregorio Valdez; Wendy Akmentin; William J Bowers; Howard Federoff; Simon Halegoua
Trk retrograde signaling requires persistent, Pincher-directed endosomes.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Howard Federoff (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: Amanda Dudak; Jinsook Kim; Bryan Cheong; Howard Federoff; Seung T Lim
Membrane palmitoylated proteins regulate trafficking and processing of nectins.
European journal of cell biology 2011;90(5):365-75.
2011: Salim Shah; Howard Federoff
Therapeutic potential of vaccines for Alzheimer's disease.
Immunotherapy 2011;3(2):287-98.
2011: Polyxeni Philippidou; Gregorio Valdez; Wendy Akmentin; William J Bowers; Howard Federoff; Simon Halegoua
Trk retrograde signaling requires persistent, Pincher-directed endosomes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(2):852-7.
2010: Bin Zheng; Zhixiang Liao; Joseph J Locascio; Kristen A Lesniak; Sarah S Roderick; Marla L Watt; Aron C Eklund; Yanli Zhang-James; Peter D Kim; Michael A Hauser; Edna Grünblatt; Linda B Moran; Silvia A Mandel; Peter Riederer; Renee M Miller; Howard Federoff; Ullrich Wüllner; Spyridon Papapetropoulos; Moussa B Youdim; Ippolita Cantuti-Castelvetri; Anne B Young; Jeffery Vance; Richard L Davis; John C Hedreen; Charles H Adler; Thomas Beach; Manuel B Graeber; Frank A Middleton; Jean-Christophe Rochet; Clemens R Scherzer
PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.
Science translational medicine 2010;2(52):52ra73.
2010: Howard Federoff; Elaine R Rubin
A new research and development policy framework for the biomedical research enterprise.
JAMA : the journal of the American Medical Association 2010;304(9):1003-4.
2010: Shyrl I Sistrunk; Princy Kumar; Jeanne Walther; Linda Gwinn; Joy Williams; Eileen S Moore; Irma Frank; Peg Weissinger; L Whitman Brown; Stephen Ray Mitchell; Howard Federoff
Georgetown University School of Medicine.
Academic medicine : journal of the Association of American Medical Colleges 2010;85(9 Suppl):S131-5.
2010: Byoung Dae Lee; Joo-Ho Shin; Jackalina VanKampen; Leonard Petrucelli; Andrew B West; Han Seok Ko; Yun-Il Lee; Kathleen A Maguire-Zeiss; William J Bowers; Howard Federoff; Valina Dawson; Ted M Dawson
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Nature medicine 2010;16(9):998-1000.
2010: Deborah A Ryan; Michael A Mastrangelo; Wade C Narrow; Mark A Sullivan; Howard Federoff; William J Bowers
Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(8):1471-81.
2010: Kathleen A Maguire-Zeiss; Howard Federoff
Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2010;117(8):1019-25.
2010: Jinsook Kim; Christina Lilliehook; Amanda Dudak; Johannes Prox; Paul Saftig; Howard Federoff; Seung T Lim
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).
The Journal of biological chemistry 2010;285(30):22919-26.
2010: Deborah A Ryan; Wade C Narrow; Howard Federoff; William J Bowers
An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies.
Journal of neuroscience methods 2010;190(2):171-9.
2010: Adrian P Kells; Jamie L Eberling; Xiaomin Su; Phillip Pivirotto; John Bringas; Piotr Hadaczek; Wade C Narrow; William J Bowers; Howard Federoff; John R Forsayeth; Krystof S Bankiewicz
Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(28):9567-77.
2010: Marc W Halterman; Molly Gill; Chris DeJesus; Mitsunori Ogihara; Nina F Schor; Howard Federoff
The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death.
The Journal of biological chemistry 2010;285(28):21329-40.
2010: Li Rebekah Feng; Howard Federoff; Stefano Vicini; Kathleen A Maguire-Zeiss
Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability.
The European journal of neuroscience 2010;32(1):10-7.
2010: S de Silva; Michael A Mastrangelo; L T Lotta; C A Burris; Howard Federoff; William J Bowers
Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform.
Gene therapy 2010;17(3):424-31.
2010: Anup Sharma; Linda M Callahan; Jai-Yoon Sul; Tae Kyung Kim; Lindy Barrett; Minsun Kim; James M Powers; Howard Federoff; james eberwine
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.
PloS one 2010;5(2):e9002.
2009: Yu Luo; Sara Arezou Sarabi; Cristina Backman; Lufei Shan; Barry Hoffer; Howard Federoff
Expression pattern of NuIP gene in adult mouse brain.
Brain research 2009;1302():42-53.
2009: Xiaomin Su; Adrian P Kells; Eric J Huang; Han S Lee; Piotr Hadaczek; Janine Beyer; John Bringas; Phillip Pivirotto; Janine Penticuff; Jamie L Eberling; Howard Federoff; John R Forsayeth; Krystof S Bankiewicz
Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.
Human gene therapy 2009;20(12):1627-40.
2009: Kelly L Sudol; Michael A Mastrangelo; Wade C Narrow; Maria E Frazer; Yona R Levites; todd golde; Howard Federoff; William J Bowers
Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(12):2031-40.
2009: Salim Shah; Howard Federoff
Drug discovery dilemma and Cura quartet collaboration.
Drug discovery today 2009;14(21-22):1006-10.
2009: John A Zaia; Howard Federoff
Death in a gene-therapy trial.
The New England journal of medicine 2009;361(18):1811.
2009: Xiaomin Su; Howard Federoff; Kathleen A Maguire-Zeiss
Mutant alpha-synuclein overexpression mediates early proinflammatory activity.
Neurotoxicity research 2009;16(3):238-54.
2009: Howard Federoff
Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease.
Neurotoxicity research 2009;16(3):261-70.
2009: Howard Federoff; Lawrence O Gostin
Evolving from reductionism to holism: is there a future for systems medicine?
JAMA : the journal of the American Medical Association 2009;302(9):994-6.
2009: Kathleen A Maguire-Zeiss; Howard Federoff
Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009;4(3):298-308.
2009: Massimo Fiandaca; Vanja Varenika; Jamie L Eberling; Tracy R McKnight; John Bringas; Phillip Pivirotto; Janine Beyer; Piotr Hadaczek; William J Bowers; John Park; Howard Federoff; John R Forsayeth; Krystof S Bankiewicz
Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.
NeuroImage 2009;47 Suppl 2():T27-35.
2009: Howard Federoff
Development of vaccination approaches for the treatment of neurological diseases.
The Journal of comparative neurology 2009;515(1):4-14.
2009: Yan Li; Seung Lim; David Hoffman; Pontus Aspenstrom; Howard Federoff; David A Rempe
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.
The Journal of cell biology 2009;185(6):1065-81.
2009: Jamie L Eberling; Adrian P Kells; Phillip Pivirotto; Janine Beyer; John Bringas; Howard Federoff; John Forsayeth; Krystof S Bankiewicz
Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys.
Human gene therapy 2009;20(5):511-8.
2009: Deborah A Ryan; Howard Federoff
Immune responses to herpesviral vectors.
Human gene therapy 2009;20(5):434-41.
2009: Louisa C Johnston; Jamie L Eberling; Phillip Pivirotto; Piotr Hadaczek; Howard Federoff; John R Forsayeth; Krystof S Bankiewicz
Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys.
Human gene therapy 2009;20(5):497-510.
2009: Yahui Grace Chiu; William J Bowers; Seung T Lim; Deborah A Ryan; Howard Federoff
Effects of herpes simplex virus amplicon transduction on murine dendritic cells.
Human gene therapy 2009;20(5):442-52.
2009: sandrine daubeuf; Divyendu Singh; Yaohong Tan; Hongiu Liu; Howard Federoff; William J Bowers; Khaled A Tolba
HSV ICP0 recruits USP7 to modulate TLR-mediated innate response.
Blood 2009;113(14):3264-75.
2008: Michelle C Janelsins; Michael A Mastrangelo; Keigan M Park; Kelly L Sudol; Wade C Narrow; Salvatore Oddo; Frank M LaFerla; Linda M Callahan; Howard Federoff; William J Bowers
Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice.
The American journal of pathology 2008;173(6):1768-82.
2008: Xiaomin Su; Kathleen A Maguire-Zeiss; Rita Giuliano; Landa Prifti; Karthik Venkatesh; Howard Federoff
Synuclein activates microglia in a model of Parkinson's disease.
Neurobiology of aging 2008;29(11):1690-701.
2008: Timothy R Mhyre; Rebekah Loy; Pierre N. Tariot; Louis A Profenno; Kathleen A Maguire-Zeiss; Dabao Zhang; Paul D. Coleman; Howard Federoff
Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium.
Neurobiology of aging 2008;29(11):1631-43.
2008: C M Dekeyser; E Zuyderhoff; R E Giuliano; Howard Federoff; Ch C Dupont-Gillain; Paul G Rouxhet
A rough morphology of the adsorbed fibronectin layer favors adhesion of neuronal cells.
Journal of biomedical materials research. Part A 2008;87(1):116-28.
2008: Yu Luo; Feng Xing; Rita Guiliano; Howard Federoff
Identification of a novel nurr1-interacting protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(37):9277-86.
2008: Louisa C Johnston; Xiaomin Su; Kathleen Maguire-Zeiss; Karen Horovitz; Irina Ankoudinova; Dmitry Guschin; Piotr Hadaczek; Howard Federoff; Krystof S Bankiewicz; John R Forsayeth
Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(8):1392-9.
2008: Marc W Halterman; Christopher De Jesus; David A Rempe; Nina F Schor; Howard Federoff
Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons.
Molecular and cellular neurosciences 2008;38(2):125-37.
2008: Maria E Frazer; Jennifer E Hughes; Michael A Mastrangelo; Jennifer L Tibbens; Howard Federoff; William J Bowers
Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(5):845-53.
2008: hovav nechushtan; Dien Pham; Yu Zhang; Daniel Morgensztern; Kyung H Yi; Seung-Uon Shin; Howard Federoff; William J Bowers; Khaled A Tolba; Joseph D Rosenblatt
Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction.
Cancer immunology, immunotherapy : CII 2008;57(5):663-75.
2008: Manfred Schubert; Xandra Breakefield; Howard Federoff; Robert M Frederickson; Pedro R Lowenstein
Gene delivery to the nervous system.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(4):640-6.
2008: Seung T Lim; Kuei-Cheng Lim; Rita E Giuliano; Howard Federoff
Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons.
The Journal of comparative neurology 2008;507(2):1228-44.
2008: Charles A Wuertzer; Mark A Sullivan; Xing Qiu; Howard Federoff
CNS delivery of vectored prion-specific single-chain antibodies delays disease onset.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):481-6.
2008: Grace Vangeison; Dan Carr; Howard Federoff; David A Rempe
The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(8):1988-93.
2008: Clark A Burris; Suresh de Silva; Wade C Narrow; Ann E Casey; Louis T Lotta; Howard Federoff; William J Bowers
Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0.
The journal of gene medicine 2008;10(2):152-64.
2008: Kathleen A Maguire-Zeiss; Timothy R Mhyre; Howard Federoff
Gazing into the future: Parkinson's disease gene therapeutics to modify natural history.
Experimental neurology 2008;209(1):101-13.
2008: Renee M Miller; Howard Federoff
Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency.
Neurobiology of aging 2008;29(1):71-7.
2007: Cindy M P Duke; Casey A Maguire; Michael C Keefer; Howard Federoff; William J Bowers; Stephen Dewhurst
HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime.
Vaccine 2007;25(42):7410-21.
2007: Kyung H Yi; hovav nechushtan; William J Bowers; Gail R. Walker; Yu Zhang; Dien G Pham; Eckhard R Podack; Howard Federoff; Khaled A Tolba; Joseph D Rosenblatt
Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo.
Cancer research 2007;67(20):10027-37.
2007: Elise B Peterson; Michael A Mastrangelo; Howard Federoff; William J Bowers
Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(10):1848-55.
2007: Kathlyn Santos; Christine M Sanfilippo; Wade C Narrow; Ann E Casey; Sol Rodriguez-Colon; Michael P McDermott; Howard Federoff; William J Bowers; Stephen Dewhurst
Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging.
Journal of virological methods 2007;145(1):37-46.
2007: Kuei-Cheng Lim; Carolyn M Tyler; Seung T Lim; Rita Giuliano; Howard Federoff
Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.
Biochemical and biophysical research communications 2007;361(3):599-604.
2007: Jill M Weimer; Jared W Benedict; Yasser Elshatory; Douglas W Short; Denia Ramirez-Montealegre; Deborah A Ryan; Noreen A Alexander; Howard Federoff; Jonathan D Cooper; David A Pearce
Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis.
Brain research 2007;1162():98-112.
2007: David A Rempe; Katherine M Lelli; Grace Vangeison; Randall S Johnson; Howard Federoff
In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage.
The Journal of biological chemistry 2007;282(22):16187-201.
2007: Deborah A Ryan; Howard Federoff
Translational considerations for CNS gene therapy.
Expert opinion on biological therapy 2007;7(3):305-18.
2007: Renee M Miller; Gretchen Kiser; Tamma Kaysser-Kranich; Cindy Casaceli; Emanuela Colla; Michael K Lee; Chockalingam Palaniappan; Howard Federoff
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.
Experimental neurology 2007;204(1):421-32.
2007: Caryl E Sortwell; William J Bowers; Scott E Counts; Mark R Pitzer; Matthew F Fleming; Susan McGuire; Kathleen A Maguire-Zeiss; Howard Federoff; Timothy J Collier
Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival.
Brain research 2007;1134(1):33-44.
2007: Kathlyn Santos; Cindy M P Duke; Sol Rodriguez-Colon; Anthony Dakwar; Shongshan Fan; Michael C Keefer; Howard Federoff; john frelinger; William J Bowers; Stephen Dewhurst
Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag.
Vaccine 2007;25(9):1634-46.
2007: Kathlyn Santos; David A L Simon; Erin Conway; William J Bowers; Soumya Mitra; Thomas H Foster; Amit A Lugade; Edith M Lord; Howard Federoff; Stephen Dewhurst; john frelinger
Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors.
Human gene therapy 2007;18(2):93-105.
2007: Howard Federoff; Timothy R Mhyre
Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene.
Neuron 2007;53(3):315-7.
2007: Yu Luo; Leigh A Henricksen; Rita E Giuliano; Llanda Prifti; Linda M Callahan; Howard Federoff
VIP is a transcriptional target of Nurr1 in dopaminergic cells.
Experimental neurology 2007;203(1):221-32.
2006: Kathleen A Maguire-Zeiss; Charlotte I Wang; Eric Yehling; Mark A Sullivan; Douglas W Short; Xiaomin Su; Geraldine Gouzer; Leigh A Henricksen; Charles A Wuertzer; Howard Federoff
Identification of human alpha-synuclein specific single chain antibodies.
Biochemical and biophysical research communications 2006;349(4):1198-205.
2006: Marc W Halterman; Rita E Giuliano; William J Bowers; Howard Federoff
Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity.
The journal of gene medicine 2006;8(11):1320-8.
2006: Renee M Miller; Howard Federoff
Microarrays in Parkinson's disease: a systematic approach.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006;3(3):319-26.
2006: Howard Federoff; Timothy R Mhyre
Systems biology: a primer.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006;3(3):293-4.
2006: Carolyn M Tyler; Charles A Wuertzer; William J Bowers; Howard Federoff
HSV amplicons: neuro applications.
Current gene therapy 2006;6(3):337-50.
2006: Jill M Weimer; Andrew W Custer; Jared W Benedict; Noreen A Alexander; Evan Kingsley; Howard Federoff; Jonathan D Cooper; David A Pearce
Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons.
Neurobiology of disease 2006;22(2):284-93.
2006: William J Bowers; Michael A Mastrangelo; Darlene F Howard; Hilary A Southerland; Kathleen A Maguire-Zeiss; Howard Federoff
Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(3):580-8.
2006: Victor L Arvanian; William J Bowers; Aileen Anderson; Philip J Horner; Howard Federoff; Lorne Mendell
Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat.
Experimental neurology 2006;197(2):347-52.
2006: Renee M Miller; Gretchen Kiser; Tamma Kaysser-Kranich; Randall J Lockner; Chockalingam Palaniappan; Howard Federoff
Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease.
Neurobiology of disease 2006;21(2):305-13.
2006: Carolyn M Tyler; Howard Federoff
CNS gene therapy and a nexus of complexity: systems and biology at a crossroads.
Cell transplantation 2006;15(3):267-73.
2006: D Rempe; G Vangeison; J Hamilton; Y Li; M Jepson; Howard Federoff
Synapsin I Cre transgene expression in male mice produces germline recombination in progeny.
Genesis (New York, N.Y. : 2000) 2006;44(1):44-9.
2005: Renee M Miller; Howard Federoff
Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2005;11(6):539-49.
2005: Maura Reinblatt; Richard H Pin; William J Bowers; Howard Federoff; Yuman Fong
Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma.
Annals of surgical oncology 2005;12(12):1025-36.
2005: Howard Federoff; William J Bowers
Immune shaping and the development of Alzheimer's disease vaccines.
Science of aging knowledge environment : SAGE KE 2005;2005(46):pe35.
2005: Michelle C Janelsins; Michael A Mastrangelo; Salvatore Oddo; Frank M LaFerla; Howard Federoff; William J Bowers
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice.
Journal of neuroinflammation 2005;2():23.
2005: Mara H de Pina-Benabou; Vanessa Szostak; Andreas Kyrozis; David Rempe; Daniela Uziel; Marcia Urban-Maldonado; Salomon Benabou; david spray; Howard Federoff; Patric Stanton; Renato Rozental
Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia.
Stroke; a journal of cerebral circulation 2005;36(10):2232-7.
2005: Howard Federoff
Alzheimer's disease: reducing the burden with ApoE2.
Gene therapy 2005;12(13):1019-29.
2005: Renee M Miller; L L Chen; Gretchen Kiser; Theresa L Giesler; Tamma Kaysser-Kranich; Chockalingam Palaniappan; Howard Federoff
Temporal evolution of mouse striatal gene expression following MPTP injury.
Neurobiology of aging 2005;26(5):765-75.
2005: William J Bowers; Michael A Mastrangelo; Hilary A Stanley; Ann E Casey; Lawrence Milo; Howard Federoff
HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses.
Neurobiology of aging 2005;26(4):393-407.
2005: Kathleen A Maguire-Zeiss; Douglas W Short; Howard Federoff
Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?
Brain research. Molecular brain research 2005;134(1):18-23.
2005: Stephanos Kyrkanides; Jennie H Miller; Sabine M Brouxhon; John A Olschowka; Howard Federoff
beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration.
Brain research. Molecular brain research 2005;133(2):286-98.
2005: Santhi Gorantla; Kathlyn Santos; Vakara Meyer; Stephen Dewhurst; William J Bowers; Howard Federoff; Howard E Gendelman; Larisa Poluektova
Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge.
Journal of virology 2005;79(4):2124-32.
2005: Kathleen A Maguire-Zeiss; Howard Federoff
Novel gene therapeutic strategies for neurodegenerative diseases.
Ernst Schering Research Foundation workshop 2005;(53):147-71.
2004: L A Henricksen; Howard Federoff
Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism.
Journal of Alzheimer's disease : JAD 2004;6(6 Suppl):S43-6.
2004: Hongmin Wang; Seong-Woon Yu; David W Koh; Jasmine Lew; Carmen Coombs; William J Bowers; Howard Federoff; Guy G Poirier; Ted M Dawson; Valina Dawson
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(48):10963-73.
2004: Richard H Pin; Maura Reinblatt; William J Bowers; Howard Federoff; Yuman Fong
Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2004;8(7):812-22; discussion 822-3.
2004: Paul D. Coleman; Howard Federoff; Roger Kurlan
A focus on the synapse for neuroprotection in Alzheimer disease and other dementias.
Neurology 2004;63(7):1155-62.
2004: Kathleen A Maguire-Zeiss; Howard Federoff
Safety of viral vectors for neurological gene therapies.
Current opinion in molecular therapeutics 2004;6(5):473-81.
2004: Victor L Arvanian; William J Bowers; Jeffrey C Petruska; Vladimir Motin; Honeyleen Manuzon; Wade C Narrow; Howard Federoff; Lorne Mendell
Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons.
Journal of neurophysiology 2004;92(4):2394-404.
2004: Renee M Miller; Linda M Callahan; Cindy Casaceli; Linlin Chen; Gretchen Kiser; Buena Chui; Tamma Kaysser-Kranich; Timothy J Sendera; Chockalingam Palaniappan; Howard Federoff
Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(34):7445-54.
2004: Maura Reinblatt; Richard H Pin; Howard Federoff; Yuman Fong
Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases.
Annals of surgery 2004;239(6):892-9; discussion 899-902.
2004: Masaki Ieda; Keiichi Fukuda; Yasuyo Hisaka; Kensuke Kimura; Haruko Kawaguchi; Jun Fujita; Kouji Shimoda; Eiko Takeshita; Hideyuki Okano; Yukiko Kurihara; Hiroki Kurihara; Junji Ishida; Akiyoshi Fukamizu; Howard Federoff; Satoshi Ogawa
Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression.
The Journal of clinical investigation 2004;113(6):876-84.
2004: Harindra R Abeysinghe; Stephen J Pollock; Nedra L Guckert; Yana Veyberman; Peter C Keng; Marc Halterman; Howard Federoff; Joseph D Rosenblatt; Nancy Wang
The role of the THY1 gene in human ovarian cancer suppression based on transfection studies.
Cancer genetics and cytogenetics 2004;149(1):1-10.
2003: Kuei-Cheng Lim; Seung T Lim; Howard Federoff
Neurotrophin secretory pathways and synaptic plasticity.
Neurobiology of aging 2003;24(8):1135-45.
2003: Stephanos Kyrkanides; Jennie H Miller; Howard Federoff
Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons.
Brain research. Molecular brain research 2003;119(1):1-9.
2003: Stephanos Kyrkanides; Jen nie H Miller; William J Bowers; Howard Federoff
Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(5):790-5.
2003: Brandon K Harvey; Chen-Fu Chang; Yung-Hsiao Chiang; William J Bowers; Marisela Morales; Barry Hoffer; Yun Wang; Howard Federoff
HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury.
Experimental neurology 2003;183(1):47-55.
2003: Yan Zhang; Yanguo Hong; Younes Bounhar; Megan Blacker; Xavier Roucou; Omar Tounekti; Emily Vereker; William J Bowers; Howard Federoff; Cynthia G Goodyer; Andréa LeBlanc
p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(19):7385-94.
2003: Pierre N. Tariot; Howard Federoff
Current treatment for Alzheimer disease and future prospects.
Alzheimer disease and associated disorders 2003;17 Suppl 4():S105-13.
2003: Xiuqing Wang; Rebecca D Wiley; Thomas G Evans; William J Bowers; Howard Federoff; Stephen Dewhurst
Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming.
Vaccine 2003;21(19-20):2288-97.
2003: Kathleen A Maguire-Zeiss; Howard Federoff
Convergent pathobiologic model of Parkinson's disease.
Annals of the New York Academy of Sciences 2003;991():152-66.
2003: William J Bowers; John A Olschowka; Howard Federoff
Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy.
Gene therapy 2003;10(11):941-5.
2003: William R Jarnagin; Jonathan S Zager; David S Klimstra; Keith A Delman; Sandeep Malhotra; Michael I Ebright; S Little; BG Derubertis; Stephen F Stanziale; Michael Hezel; Howard Federoff; Yuman Fong
Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection.
Cancer gene therapy 2003;10(3):215-23.
2003: John A Olschowka; William J Bowers; Sean D Hurley; Michael A Mastrangelo; Howard Federoff
Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):218-27.
2003: Jennifer E Snyder; William J Bowers; Alexandra M Livingstone; F Eun-Hyung Lee; Howard Federoff; Tim R Mosmann
Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing.
Nature medicine 2003;9(2):231-5.
2003: Howard Federoff
CNS diseases amenable to gene therapy.
Ernst Schering Research Foundation workshop 2003;(43):117-58.
2002: Khaled A Tolba; William J Bowers; Jacquelyn Muller; Vickie Housekneckt; Rita E Giuliano; Howard Federoff; Joseph D Rosenblatt
Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity.
Cancer research 2002;62(22):6545-51.
2002: Joseph J Bennett; Keith A Delman; Bryan M Burt; Adam Mariotti; Sandeep Malhotra; Jonathan S Zager; Henrik Petrowsky; Stephen Mastorides; Howard Federoff; Yuman Fong
Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer.
Cancer gene therapy 2002;9(11):935-45.
2002: Khaled A Tolba; William J Bowers; David J Eling; Ann E Casey; Thomas Kipps; Howard Federoff; Joseph D Rosenblatt
HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(4):455-63.
2002: Kathleen A Maguire-Zeiss; William J Bowers; Howard Federoff
Somatic mosaic approaches and the aging brain.
Neurobiology of aging 2002;23(5):977-84.
2002: William J Bowers; Howard Federoff
Amyloid immunotherapy-engendered CNS inflammation.
Neurobiology of aging 2002;23(5):675-6; discussion 683-4.
2002: Keith A Delman; Jonathan S Zager; Joseph J Bennett; Sandeep Malhotra; Michael I Ebright; Priscilla F McAuliffe; Marc W Halterman; Howard Federoff; Yuman Fong
Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer.
Annals of surgery 2002;236(3):337-42; discussion 342-3.
2002: Seong-Woon Yu; Hongmin Wang; Marc F Poitras; Carmen Coombs; William J Bowers; Howard Federoff; Guy G Poirier; Ted M Dawson; Valina Dawson
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.
Science (New York, N.Y.) 2002;297(5579):259-63.
2002: William J Bowers; Xiaowei Chen; Huang Guo; D Robert Frisina; Howard Federoff; Robert D Frisina
Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(1):12-8.
2002: Eric R Detrait; William J Bowers; Marc W Halterman; Rita E Giuliano; Lisa Bennice; Howard Federoff; Eric K Richfield
Reporter gene transfer induces apoptosis in primary cortical neurons.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):723-30.
2002: Peter K Hocknell; Rebecca D Wiley; Xiuqing Wang; Thomas G Evans; William J Bowers; Tomas Hanke; Howard Federoff; Stephen Dewhurst
Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses.
Journal of virology 2002;76(11):5565-80.
2002: Eric K Richfield; Mona Thiruchelvam; Deborah A Cory-Slechta; Charles A Wuertzer; Raul R Gainetdinov; Marc G Caron; Donato A Di Monte; Howard Federoff
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.
Experimental neurology 2002;175(1):35-48.
2002: Andrew I Brooks; Colleen S Stein; Stephanie Hughes; Jason A Heth; Paul M McCray; Sybille L Sauter; Julie C Johnston; Deborah A Cory-Slechta; Howard Federoff; Beverly L Davidson
Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6216-21.
2002: Issam A Halaby; Sean P Lyden; Mark G Davies; Elisa Roztocil; Linda J Salamone; Andrew I Brooks; Richard M Green; Howard Federoff; William J Bowers
Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):300-6.
2002: Diana Casper; Samara J Engstrom; Gautam R Mirchandani; Ann Pidel; David Palencia; Paul H Cho; Michael Brownlee; Diane Edelstein; Howard Federoff; William J Sonstein
Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer.
Cell transplantation 2002;11(4):331-49.
2002: Steven W Wang; Xiuqian Mu; William J Bowers; Dong-Seob Kim; Daniel J Plas; Michael C Crair; Howard Federoff; Lin Gan; William H Klein
Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.
Development (Cambridge, England) 2002;129(2):467-77.
2001: Richard A Willis; William J Bowers; Michael J Turner; Terrence L Fisher; C Siddiq Abdul Alim; Darlene F Howard; Howard Federoff; Edith M Lord; john frelinger
Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice.
Human gene therapy 2001;12(15):1867-79.
2001: Kathleen A Maguire-Zeiss; William J Bowers; Howard Federoff
HSV vector-mediated gene delivery to the central nervous system.
Current opinion in molecular therapeutics 2001;3(5):482-90.
2001: H H DeCory; KM Piech-Dumas; Shey-Shing Sheu; Howard Federoff; MW Anders
Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(10):1256-62.
2001: J F Carew; David A Kooby; Marc W Halterman; S H Kim; Howard Federoff; Yuman Fong
A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(3):250-6.
2001: Nurit Ballas; Elena Battaglioli; F Atouf; M E Andres; Josh Chenoweth; M E Anderson; C Burger; Mariko Moniwa; James Davie; William J Bowers; Howard Federoff; David W Rose; Michael G Rosenfeld; Paul Brehm; Gail Mandel
Regulation of neuronal traits by a novel transcriptional complex.
Neuron 2001;31(3):353-65.
2001: Jonathan S Zager; Keith A Delman; Sandeep Malhotra; Michael I Ebright; Joseph J Bennett; T Kates; Marc W Halterman; Howard Federoff; Yuman Fong
Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer.
Molecular medicine (Cambridge, Mass.) 2001;7(8):561-8.
2001: Henrik Petrowsky; Gretchen D Roberts; David A Kooby; Bryan M Burt; Joseph J Bennett; Keith A Delman; Stephen F Stanziale; TM Delohery; William P Tong; Howard Federoff; Yuman Fong
Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus.
Journal of virology 2001;75(15):7050-8.
2001: Khaled A Tolba; William J Bowers; Shannon P Hilchey; Marc W Halterman; Darlene F Howard; Rita E Giuliano; Howard Federoff; Joseph D Rosenblatt
Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia.
Blood 2001;98(2):287-95.
2001: Joseph J Bennett; Juri Gelovani Tjuvajev; P Johnson; Mikhail Doubrovin; Timothy Akhurst; S Malholtra; Trevor Hackman; Julius Balatoni; Ronald Finn; Steven M Larson; Howard Federoff; Ronald Blasberg; Yuman Fong
Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer.
Nature medicine 2001;7(7):859-63.
2001: X Chen; Robert D Frisina; William J Bowers; D Robert Frisina; Howard Federoff
HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(6):958-63.
2001: P J Cozzi; Sandeep Malhotra; Priscilla F McAuliffe; David A Kooby; Howard Federoff; B Huryk; P Johnson; Peter T Scardino; Warren D W Heston; Yuman Fong
Intravesical oncolytic viral therapy using attenuated, replication-competent herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(7):1306-8.
2001: Mandy Jackson; W Song; M Y Liu; Lin Jin; Margaret Dykes-Hoberg; Chien-liang Glenn Lin; William J Bowers; Howard Federoff; P C Sternweis; Jeffrey rothstein
Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins.
Nature 2001;410(6824):89-93.
2001: Ari D Brooks; B Ng; D Liu; Michael Brownlee; M Burt; Howard Federoff; Yuman Fong
Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy.
Surgery 2001;129(3):324-34.
2001: William J Bowers; Darlene F Howard; Andrew I Brooks; Marc W Halterman; Howard Federoff
Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers.
Gene therapy 2001;8(2):111-20.
2000: Andrew I Brooks; Deborah A Cory-Slechta; Howard Federoff
Gene-experience interaction alters the cholinergic septohippocampal pathway of mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13378-83.
2000: Andrew I Brooks; Deborah A Cory-Slechta; William J Bowers; S L Murg; Howard Federoff
Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus.
Human gene therapy 2000;11(17):2341-52.
2000: Priscilla F McAuliffe; William R Jarnagin; P Johnson; Keith A Delman; Howard Federoff; Yuman Fong
Effective treatment of pancreatic tumors with two multimutated herpes simplex oncolytic viruses.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2000;4(6):580-8.
2000: Andrew I Brooks; Deborah A Cory-Slechta; S L Murg; Howard Federoff
Repeated acquisition and performance chamber for mice: a paradigm for assessment of spatial learning and memory.
Neurobiology of learning and memory 2000;74(3):241-58.
2000: A E Telfeian; Howard Federoff; P Leone; Matthew J During; A Williamson
Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro.
Neurobiology of disease 2000;7(4):362-74.
2000: William R Jarnagin; Keith A Delman; David A Kooby; Stephen Mastorides; Jonathan S Zager; Murray F Brennan; Leslie H Blumgart; Howard Federoff; Yuman Fong
Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model.
Annals of surgery 2000;231(5):762-71.
2000: HM Karpoff; David A Kooby; Michael D'Angelica; J Mack; D H Presky; Michael Brownlee; Howard Federoff; Yuman Fong
Efficient cotransduction of tumors by multiple herpes simplex vectors: implications for tumor vaccine production.
Cancer gene therapy 2000;7(4):581-8.
2000: William J Bowers; Darlene F Howard; Howard Federoff
Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(3):294-9.
2000: Joseph J Bennett; David A Kooby; Keith A Delman; Priscilla F McAuliffe; Marc W Halterman; Howard Federoff; Yuman Fong
Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer.
Journal of molecular medicine (Berlin, Germany) 2000;78(3):166-74.
1999: Howard Federoff
Novel targets for CNS gene therapy.
Gene therapy 1999;6(12):1907-8.
1999: Thomas R Van De Water; Hinrich Staecker; M W Halterman; Howard Federoff
Gene therapy in the inner ear. Mechanisms and clinical implications.
Annals of the New York Academy of Sciences 1999;884():345-60.
1999: Michael D'Angelica; C Tung; Peter J Allen; Marc W Halterman; Keith A Delman; TM Delohery; David S Klimstra; Michael Brownlee; Howard Federoff; Yuman Fong
Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity.
Molecular medicine (Cambridge, Mass.) 1999;5(9):606-16.
1999: Marc W Halterman; Howard Federoff
HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia.
Experimental neurology 1999;159(1):65-72.
1999: Marc W Halterman; C C Miller; Howard Federoff
Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):6818-24.
1999: David A Kooby; J F Carew; Marc W Halterman; J E Mack; Joseph R Bertino; Leslie H Blumgart; Howard Federoff; Yuman Fong
Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(11):1325-34.
1999: Howard Federoff
An infectious conspiracy: the case for HSV-1 and APOEepsilon4 in Alzheimer's disease.
Neurobiology of aging 1999;20(4):467-8.
1999: J F Carew; David A Kooby; Marc W Halterman; Howard Federoff; Yuman Fong
Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207).
Human gene therapy 1999;10(10):1599-606.
1999: S M White; Matthew J Renda; N Y Nam; E Klimatcheva; Y Zhu; J Fisk; Marc W Halterman; BJ Rimel; Howard Federoff; Shree Pandya; Joseph D Rosenblatt; Vicente Planelles
Lentivirus vectors using human and simian immunodeficiency virus elements.
Journal of virology 1999;73(4):2832-40.
1999: Andrew I Brooks; C A Chadwick; Harris A Gelbard; Deborah A Cory-Slechta; Howard Federoff
Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.
Brain research 1999;823(1-2):1-10.
1999: J H Lee; Howard Federoff; L O Schoeniger
G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1999;3(2):127-31; discussion 132-3.
1999: Francis J Antonawich; Howard Federoff; JN Davis
BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia.
Experimental neurology 1999;156(1):130-7.
1999: Andrew I Brooks; Marc W Halterman; Howard Federoff
Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization.
Neuroreport 1999;10(2):337-44.
1999: M Kutubuddin; Howard Federoff; Pia M Challita-Eid; Marc W Halterman; B Day; Mark Atkinson; Vicente Planelles; Joseph D Rosenblatt
Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors.
Blood 1999;93(2):643-54.
1999: Michael D'Angelica; HM Karpoff; Marc W Halterman; J Ellis; David S Klimstra; Diane Edelstein; Michael Brownlee; Howard Federoff; Yuman Fong
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
Cancer immunology, immunotherapy : CII 1999;47(5):265-71.
1998: J F Carew; Howard Federoff; Marc W Halterman; Dennis H Kraus; Howard E Savage; Peter G Sacks; Stimson P Schantz; Jatin P Shah; Yuman Fong
Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector.
American journal of surgery 1998;176(5):404-8.
1998: BM Heath; J Xia; E Dong; R H An; A Brooks; C Liang; Howard Federoff; Robert Kass
Overexpression of nerve growth factor in the heart alters ion channel activity and beta-adrenergic signalling in an adult transgenic mouse.
The Journal of physiology 1998;512 ( Pt 3)():779-91.
1998: S X Deng; Nariman Panahian; HJ James; Harris A Gelbard; Howard Federoff; Stephen Dewhurst; Leon G Epstein
Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption.
Journal of neuroscience methods 1998;83(2):159-64.
1998: Hinrich Staecker; R Gabaizadeh; Howard Federoff; Thomas R Van De Water
Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1998;119(1):7-13.
1998: Samuel Parry; J Holder; Marc W Halterman; M D Weitzman; A R Davis; Howard Federoff; Jerome F Strauss
Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry.
The American journal of pathology 1998;152(6):1521-9.
1998: Andrew I Brooks; Marc W Halterman; C A Chadwick; B L Davidson; M Haak-Frendscho; C Radel; C Porter; Howard Federoff
Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector.
Journal of neuroscience methods 1998;80(2):137-47.
1998: Howard Federoff; M Atkinson
Towards gene therapy of neurodegenerative disease.
Progress in brain research 1998;117():503-10.
1997: B Lu; Howard Federoff; Y Wang; lowell goldsmith; Glynis Scott
Topical application of viral vectors for epidermal gene transfer.
The Journal of investigative dermatology 1997;108(5):803-8.
1997: William J Bowers; Darlene F Howard; Howard Federoff
Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease.
Experimental neurology 1997;144(1):58-68.
1997: HM Karpoff; Michael D'Angelica; S Blair; Michael Brownlee; Howard Federoff; Yuman Fong
Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon.
The Journal of clinical investigation 1997;99(4):799-804.
1997: Howard Federoff; A Brooks; B Muhkerjee; T Corden
Somatic gene transfer approaches to manipulate neural networks.
Journal of neuroscience methods 1997;71(1):133-42.
1997: Andrew I Brooks; B Muhkerjee; Nariman Panahian; Deborah A Cory-Slechta; Howard Federoff
Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase.
Nature biotechnology 1997;15(1):57-62.
1996: C Tung; Howard Federoff; Michael Brownlee; HM Karpoff; T Weigel; Murray F Brennan; Yuman Fong
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Human gene therapy 1996;7(18):2217-24.
1996: B K Jin; M Belloni; B Conti; Howard Federoff; R Starr; Jin H Son; H Baker; Tong H Joh
Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector.
Human gene therapy 1996;7(16):2015-24.
1996: Y Liu; Alex Rabinovitch; Wilma L Suarez-Pinzon; B Muhkerjee; Michael Brownlee; Diane Edelstein; Howard Federoff
Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis.
Human gene therapy 1996;7(14):1719-26.
1996: L J Goodman; J Valverde; F Lim; M D Geschwind; Howard Federoff; Alfred I Geller; F Hefti
Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons.
Molecular and cellular neurosciences 1996;7(3):222-38.
1996: M D Geschwind; C J Hartnick; W Liu; J Amat; Thomas R Van De Water; Howard Federoff
Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration.
Human gene therapy 1996;7(2):173-82.
1995: Yuman Fong; Howard Federoff; Michael Brownlee; D Blumberg; Leslie H Blumgart; Murray F Brennan
Rapid and efficient gene transfer in Human hepatocytes by herpes viral vectors.
Hepatology (Baltimore, Md.) 1995;22(3):723-9.
1995: M D Linnik; P Zahos; M D Geschwind; Howard Federoff
Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia.
Stroke; a journal of cerebral circulation 1995;26(9):1670-4; discussion 1675.
1995: Hans-Peter Hammes; Howard Federoff; Michael Brownlee
Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes.
Molecular medicine (Cambridge, Mass.) 1995;1(5):527-34.
1995: A F Andrade-Rozental; Renato Rozental; A Hassankhani; david spray; Howard Federoff
Characterization of two populations of ectopic cells isolated from the hearts of NGF transgenic mice.
Developmental biology 1995;169(2):533-46.
1995: P Casaccia-Bonnefil; A Stelzer; Howard Federoff; Peter Bergold
A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit.
Neuroscience letters 1995;191(1-2):67-70.
1995: A Hassankhani; M E Steinhelper; Mark H Soonpaa; Ellen B Katz; Doris Taylor; A Andrade-Rozental; Stephen M Factor; Jacob J Steinberg; Loren J Field; Howard Federoff
Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells.
Developmental biology 1995;169(1):309-21.
1995: B Lu; Howard Federoff
Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression.
Human gene therapy 1995;6(4):419-28.
1995: B Lu; Sanjeev Gupta; Howard Federoff
Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector.
Hepatology (Baltimore, Md.) 1995;21(3):752-9.
1995: Bruce T Volpe; T C Wessel; B Mukherjee; Howard Federoff
Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia.
Neuroscience letters 1995;186(2-3):157-60.
1995: Enrique Mesri; Howard Federoff; Michael Brownlee
Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice.
Circulation research 1995;76(2):161-7.
1994: M D Geschwind; John A Kessler; Alfred I Geller; Howard Federoff
Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector.
Brain research. Molecular brain research 1994;24(1-4):327-35.
1994: H Xu; Howard Federoff; J Maragos; Luis F Parada; John A Kessler
Viral transduction of trkA into cultured nodose and spinal motor neurons conveys NGF responsiveness.
Developmental biology 1994;163(1):152-61.
1994: R G Starr; B Lu; Howard Federoff
Functional characterization of the rat GAP-43 promoter.
Brain research 1994;638(1-2):211-20.
1994: J R De Leon; Howard Federoff; dennis dickson; Karen Lynn Vikstrom; Glenn I Fishman
Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):519-23.
1994: Stuart C Apfel; Joseph C Arezzo; Michael Brownlee; Howard Federoff; John A Kessler
Nerve growth factor administration protects against experimental diabetic sensory neuropathy.
Brain research 1994;634(1):7-12.
1994: M C Bohn; Q Lin; Howard Federoff
Stimulation of neurite growth rat adrenal chromaffin cells infected with a defective herpes simplex virus carrying an NGF minigene.
Gene therapy 1994;1 Suppl 1():S70.
1993: P Casaccia-Bonnefil; E Benedikz; H Shen; A Stelzer; Diane Edelstein; M Geschwind; Michael Brownlee; Howard Federoff; Peter Bergold
Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices.
Journal of neuroscience methods 1993;50(3):341-51.
1993: R H Lustig; P Hua; M C Wilson; Howard Federoff
Ontogeny, sex dimorphism, and neonatal sex hormone determination of synapse-associated messenger RNAs in rat brain.
Brain research. Molecular brain research 1993;20(1-2):101-10.
1993: Peter Bergold; P Casaccia-Bonnefil; X L Zeng; Howard Federoff
Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6165-9.
1993: Howard Federoff; D Lawrence; Michael Brownlee
Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth.
Diabetes 1993;42(4):509-13.
1992: Howard Federoff; M D Geschwind; Alfred I Geller; John A Kessler
Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1636-40.
1991: R H Lustig; Marius Sudol; Donald Pfaff; Howard Federoff
Estrogenic regulation and sex dimorphism of growth-associated protein 43 kDa (GAP-43) messenger RNA in the rat.
Brain research. Molecular brain research 1991;11(2):125-32.
1990: Beverly M K Biller; Howard Federoff; James I Koenig; Anne Klibanski
Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea.
The Journal of clinical endocrinology and metabolism 1990;70(2):311-7.
1989: Suzanne M de la Monte; Howard Federoff; S C Ng; E Grabczyk; Mark C Fishman
GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system.
Brain research. Developmental brain research 1989;46(2):161-8.
1988: Howard Federoff; E Grabczyk; Mark C Fishman
Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids.
The Journal of biological chemistry 1988;263(36):19290-5.
1983: Howard Federoff; T R Eccleshall; J Marmur
Carbon catabolite repression of maltase synthesis in Saccharomyces carlsbergensis.
Journal of bacteriology 1983;156(1):301-7.
1983: Howard Federoff; T R Eccleshall; J Marmur
Regulation of maltase synthesis in Saccharomyces carlsbergensis.
Journal of bacteriology 1983;154(3):1301-8.
1982: Howard Federoff; J D Cohen; T R Eccleshall; Richard Needleman; B A Buchferer; J Giacalone; J Marmur
Isolation of a maltase structural gene from Saccharomyces carlsbergensis.
Journal of bacteriology 1982;149(3):1064-70.
1980: J D Cohen; T R Eccleshall; Richard Needleman; Howard Federoff; B A Buchferer; J Marmur
Functional expression in yeast of the Escherichia coli plasmid gene coding for chloramphenicol acetyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(2):1078-82.
1978: Richard Needleman; Howard Federoff; T R Eccleshall; B Buchferer; J Marmur
Purification and characterization of an alpha-glucosidase from Saccharomyces carlsbergensis.
Biochemistry 1978;17(22):4657-61.