FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Martijn Brugman

Research Profile

Living Beings

Chemicals & Drugs

Anatomy

Disorders

Physiology

Procedures

Phenomena

Virus Integration

Co-author Network

Publications

TOP 3
Martijn Brugman; Olga S Kustikova; Ute Modlich; Michael Rothe; Axel Schambach; Sebastian Suerbaum; Julia D Suerth; Christopher Baum
Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.
Olga S Kustikova; Zhixiong Li; T Neumann; Ingo Roeder; Axel Schambach; Brigitte Schlegelberger; A Schwarzer; M Stahlhut; Doris Steinemann; M Yang; Martijn Brugman; S Gerdes; T C Ha; N Heinz; Christopher Baum
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.
Marshall W Huston; Andrew Stubbs; Peter van der Spek; Martijn Brugman; Sebastiaan Horsman; Gerard Wagemaker
Comprehensive investigation of parameter choice in viral integration site analysis and its effects on the gene annotations produced.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Martijn Brugman (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Martijn Brugman; Olga S Kustikova; Ute Modlich; Michael Rothe; Axel Schambach; Sebastian Suerbaum; Julia D Suerth; Christopher Baum
Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.
Human gene therapy methods 2013;24(2):68-79.
2013: Olga S Kustikova; Zhixiong Li; T Neumann; Ingo Roeder; Axel Schambach; Brigitte Schlegelberger; A Schwarzer; M Stahlhut; Doris Steinemann; M Yang; Martijn Brugman; S Gerdes; T C Ha; N Heinz; Christopher Baum
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.
Leukemia 2013;27(5):1127-38.
2012: Marshall W Huston; Andrew Stubbs; Peter van der Spek; Martijn Brugman; Sebastiaan Horsman; Gerard Wagemaker
Comprehensive investigation of parameter choice in viral integration site analysis and its effects on the gene annotations produced.
Human gene therapy 2012;23(11):1209-19.
2012: Paul P C Roozen; Martijn Brugman; Frank Staal
Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches.
Annals of the New York Academy of Sciences 2012;1266():78-93.
2012: Julia D Suerth; Manfred Schmidt; Jens-Uwe Appelt; Christopher Baum; Martijn Brugman; Manuel Grez; Niels Heinz; Kerstin B Kaufmann; Tobias Maetzig; Ute Modlich; Axel Schambach
Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):1022-32.
2012: Tiago C Luis; Martijn Brugman; M Ichii; P Kincade; Frank Staal
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development.
Leukemia 2012;26(3):414-21.
2012: Machteld M Tiemessen; Jacques J M van Dongen; Miranda R M Baert; Martijn Brugman; Hans Clevers; Farbod Famili; Jules P P Meijerink; Ugur Ozbek; Daniela C F Salvatori; Tom Schonewille; Frank J T Staal
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.
PLoS biology 2012;10(11):e1001430.
2011: Annette Deichmann; Cynthia E Dunbar; Alain Fischer; Richard Gabriel; H Bobby Gaspar; Hanno Glimm; Manuel Grez; Salima Hacein-Bey-Abina; Dieter Hoelzer; Steven J Howe; Fulvio Mavilio; Marion G Ott; Anna Paruzynski; Manfred Schmidt; Kerstin Schwarzwaelder; Reinhard Seger; Adrian J Thrasher; Monique M A Verstegen; Christof von Kalle; Ulrich Abel; Alessandro Aiuti; Anne Arens; Cynthia C Bartholomae; Christopher Baum; Martijn Brugman; Barbara Cassani; Claudia Cattoglio; Marina Cavazzana-Calvo; Gerard Wagemaker
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(11):2031-9.
2011: Tiago C Luis; Brigitta A E Naber; Paul P C Roozen; Martijn Brugman; Edwin F E de Haas; Willem E Fibbe; Riccardo Fodde; Mehrnaz Ghazvini; Jacques J M van Dongen; Frank Staal
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.
Cell stem cell 2011;9(4):345-56.
2011: Marshall W Huston; Yuedan Li; Fulvio Mavilio; Ali Nowrouzi; Axel Schambach; Manfred Schmidt; Adrian J Thrasher; Niek P van Til; Monique M A Verstegen; Trudi P Visser; Christof von Kalle; Shazia Arshad; Christopher Baum; Mike P Blundell; Martijn Brugman; Claudia Cattoglio; Fang Zhang; Gerard Wagemaker
Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1867-77.
2011: Melanie Galla; Gudrun Göhring; Niels Heinz; Zoltán Ivics; Zsuzsanna Izsvák; Johannes Kuehle; Kathrin Lange; Tobias Maetzig; Axel Schambach; Daniela Zychlinski; Martijn Brugman; Christine S Falk; Christopher Baum
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.
Nucleic acids research 2011;39(16):7147-60.
2011: M Pincha; G Salguero; B S Sundarasetty; D Wedekind; Martijn Brugman; Guntram Büsche; A Ganser; Ralf Gutzmer; A C Jirmo; N Kasahara; A Lin; Ute Modlich; Renata Stripecke
Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.
Gene therapy 2011;18(8):750-64.
2011: Dirk Heckl; Daniel C Wicke; Martijn Brugman; Johann Meyer; Axel Schambach; Guntram Büsche; Matthias Ballmaier; Christopher Baum; Ute Modlich
Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.
Blood 2011;117(14):3737-47.
2011: Eva Warlich; Johannes Kuehle; Tobias Cantz; Martijn Brugman; Tobias Maetzig; Melanie Galla; Adam A Filipczyk; Stephan Halle; Hannes Klump; Hans R Schöler; Christopher Baum; Timm Schroeder; Axel Schambach
Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(4):782-9.
2011: Tobias Maetzig; Martijn Brugman; Stefan Bartels; Niels Heinz; Olga S Kustikova; Ute Modlich; Zhixiong Li; Melanie Galla; Bernhard Schiedlmeier; Axel Schambach; Christopher Baum
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood 2011;117(11):3053-64.
2011: Mathias Rhein; Adrian Schwarzer; Min Yang; Volkhard Kaever; Martijn Brugman; Johann Meyer; Arnold Ganser; Christopher Baum; Zhixiong Li
Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models.
Annals of hematology 2011;90(3):283-92.
2010: Yuk Yin Ng; M R M Baert; Karin Pike-Overzet; M Rodijk; Martijn Brugman; A Schambach; C Baum; Rudolf W Hendriks; J J M van Dongen; Frank Staal
Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.
Leukemia 2010;24(9):1617-30.
2010: Olga S Kustikova; Martijn Brugman; Christopher Baum
The genomic risk of somatic gene therapy.
Seminars in cancer biology 2010;20(4):269-78.
2010: T Maetzig; Melanie Galla; Martijn Brugman; R Loew; Christopher Baum; Axel Schambach
Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.
Gene therapy 2010;17(3):400-11.
2009: Ute Modlich; Susana Navarro; Daniela Zychlinski; Tobias Maetzig; Sabine Knoess; Martijn Brugman; Axel Schambach; Sabine Charrier; Anne Galy; Adrian J Thrasher; Juan Bueren; Christopher Baum
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1919-28.
2009: Olga S Kustikova; Bernhard Schiedlmeier; Martijn Brugman; Maike Stahlhut; Stefan Bartels; Zhixiong Li; Christopher Baum
Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(9):1537-47.
2009: Kerstin Cornils; Claudia Lange; Axel Schambach; Martijn Brugman; Regine Nowak; Michael Lioznov; Christopher Baum; Boris Fehse
Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(1):131-43.
2008: Sebastian Newrzela; Kerstin Cornils; Zhixiong Li; Christopher Baum; Martijn Brugman; Marianne Hartmann; Johann Meyer; Sylvia Hartmann; Martin-Leo Hansmann; Boris Fehse; Dorothee von Laer
Resistance of mature T cells to oncogene transformation.
Blood 2008;112(6):2278-86.
2008: Steven J Howe; Marc R Mansour; Kerstin Schwarzwaelder; Cynthia Bartholomae; Michael Hubank; Helena Kempski; Martijn Brugman; Karin Pike-Overzet; Stephen J Chatters; Dick de Ridder; Kimberly C Gilmour; Stuart Adams; Susannah I Thornhill; Kathryn L Parsley; Frank Staal; Rosemary E Gale; David C Linch; Jinhua Bayford; Lucie Brown; Michelle Quaye; Christine Kinnon; Philip Ancliff; David K Webb; Manfred Schmidt; Christof von Kalle; H Bobby Gaspar; Adrian J Thrasher
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
The Journal of clinical investigation 2008;118(9):3143-50.
2008: Ute Modlich; Axel Schambach; Martijn Brugman; D C Wicke; S Knoess; Zhixiong Li; T Maetzig; Cornelia Rudolph; Brigitte Schlegelberger; Christopher Baum
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16.
Leukemia 2008;22(8):1519-28.
2007: Kerstin Schwarzwaelder; Steven J Howe; Manfred Schmidt; Martijn Brugman; Annette Deichmann; Hanno Glimm; Sonja Schmidt; Claudia Prinz; Manuela Wissler; Douglas J S King; Fang Zhang; Kathryn L Parsley; Kimberly C Gilmour; Joanna Sinclair; Jinhua Bayford; Rachel Peraj; Karin Pike-Overzet; Frank Staal; Dick de Ridder; Christine Kinnon; Ulrich Abel; Gerard Wagemaker; H Bobby Gaspar; Adrian J Thrasher; Christof von Kalle
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.
The Journal of clinical investigation 2007;117(8):2241-9.
2007: Annette Deichmann; Salima Hacein-Bey-Abina; Manfred Schmidt; Alexandrine Garrigue; Martijn Brugman; Jingqiong Hu; Hanno Glimm; Gabor Gyapay; Bernard Prum; Christopher C Fraser; Nicolas Fischer; Kerstin Schwarzwaelder; Maria-Luise Siegler; Dick de Ridder; Karin Pike-Overzet; Steven J Howe; Adrian J Thrasher; Gerard Wagemaker; Ulrich Abel; Frank Staal; Eric Delabesse; Jean-Luc Villeval; Bruce Aronow; Christophe Hue; Claudia Prinz; Manuela Wissler; Chuck Klanke; Jean Weissenbach; Ian Alexander; Alain Fischer; Christof von Kalle; Marina Cavazzana-Calvo
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.
The Journal of clinical investigation 2007;117(8):2225-32.
2007: Karin Pike-Overzet; Dick de Ridder; Floor Weerkamp; Miranda Baert; M M A Verstegen; Martijn Brugman; Steven J Howe; Marcel J T Reinders; Adrian J Thrasher; Gerard Wagemaker; Jacques J M van Dongen; Frank Staal
Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.
Leukemia 2007;21(4):754-63.
2007: Olga S Kustikova; Hartmut Geiger; Zhixiong Li; Martijn Brugman; Stuart M Chambers; Chad A Shaw; Karin Pike-Overzet; Dick de Ridder; Frank Staal; Gottfried von Keudell; Kerstin Cornils; Kalpana J Nattamai; Ute Modlich; Gerard Wagemaker; Margaret A Goodell; Boris Fehse; Christopher Baum
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.
Blood 2007;109(5):1897-907.
2006: Karin Pike-Overzet; Dick de Ridder; Floor Weerkamp; Miranda Baert; Monique M Verstegen; Martijn Brugman; Steven J Howe; Marcel J T Reinders; Adrian J Thrasher; Gerard Wagemaker; Jacques J M van Dongen; Frank Staal
Gene therapy: is IL2RG oncogenic in T-cell development?
Nature 2006;443(7109):E5; discussion E6-7.
2006: Floor Weerkamp; Miranda Baert; Martijn Brugman; Willem A Dik; Edwin F E de Haas; Trudi P Visser; Christianne J M De Groot; Gerard Wagemaker; Jacques J M van Dongen; Frank Staal
Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.
Blood 2006;107(8):3131-7.
2002: Martijn Brugman; Marie-José Goumans; Alexander Rosendahl; Martijn Brugman; Susumu Itoh; Franck Lebrin; Paschalis Sideras; Peter ten Dijke
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells.
Circulation 2002;106(17):2263-70.