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Bernd Bukau

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Physiology

Protein Folding

Living Beings

Escherichia coli

Phenomena

Protein Binding

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

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Co-Publications
Name
39
Mogk, Axel
25
Mayer, Matthias
22
Deuerling, Elke
13
Rüdiger, Stefan
13
dougan, david
12
Kramer, Günter
12
Tomoyasu, Toshifumi
11
Schlieker, Christian
11
Schneider-Mergener, Jens
9
Patzelt, Holger
8
Rist, Wolfgang
8
Vorderwülbecke, Sonja
7
Merz, Frieder
7
Weibezahn, Jimena
7
Turgay, Kürsad

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Publications

TOP 3
Hoffmann Anja; Bukau Bernd; Kramer Günter
Structure and function of the molecular chaperone Trigger Factor.
Andréasson Claes; Rampelt Heike; Fiaux Jocelyne; Druffel-Augustin Silke; Bukau Bernd
The endoplasmic reticulum Grp170 acts as a nucleotide exchange factor of Hsp70 via a mechanism similar to that of the cytosolic Hsp110.
Winkler Juliane; Seybert Anja; König Lars; Pruggnaller Sabine; Haselmann Uta; Sourjik Victor; Weiss Matthias; Frangakis Achilleas S; Mogk Axel; Bukau Bernd
Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing.

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All Publications

2010: Hoffmann Anja; Bukau Bernd; Kramer Günter
Structure and function of the molecular chaperone Trigger Factor.
Biochimica et biophysica acta 2010;1803(6):650-61.
2010: Andréasson Claes; Rampelt Heike; Fiaux Jocelyne; Druffel-Augustin Silke; Bukau Bernd
The endoplasmic reticulum Grp170 acts as a nucleotide exchange factor of Hsp70 via a mechanism similar to that of the cytosolic Hsp110.
The Journal of biological chemistry 2010;285(16):12445-53.
2010: Winkler Juliane; Seybert Anja; König Lars; Pruggnaller Sabine; Haselmann Uta; Sourjik Victor; Weiss Matthias; Frangakis Achilleas S; Mogk Axel; Bukau Bernd
Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing.
The EMBO journal 2010;29(5):910-23.
2010: Mogk Axel; Bukau Bernd
Cell biology. When the beginning marks the end.
Science (New York, N.Y.) 2010;327(5968):966-7.
2010: Haslberger Tobias; Bukau Bernd; Mogk Axel
Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2010;88(1):63-75.
2010: Fiaux Jocelyne; Horst Janina; Scior Annika; Preissler Steffen; Koplin Ansgar; Bukau Bernd; Deuerling Elke
Structural analysis of the ribosome-associated complex (RAC) reveals an unusual Hsp70/Hsp40 interaction.
The Journal of biological chemistry 2010;285(5):3227-34.
2009: Schmidt Ronny; Bukau Bernd; Mogk Axel
Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli.
Research in microbiology 2009;160(9):629-36.
2009: Hoffmann Anja; Bukau Bernd
Trigger factor finds new jobs and contacts.
Nature structural & molecular biology 2009;16(10):1006-8.
2009: Rutkowska Anna; Beerbaum Monika; Rajagopalan Nandhakishore; Fiaux Jocelyne; Schmieder Peter; Kramer Günter; Oschkinat Hartmut; Bukau Bernd
Large-scale purification of ribosome-nascent chain complexes for biochemical and structural studies.
FEBS letters 2009;583(14):2407-13.
2009: Tessarz Peter; Schwarz Michael; Mogk Axel; Bukau Bernd
The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins.
Molecular and cellular biology 2009;29(13):3738-45.
2009: Kramer Günter; Boehringer Daniel; Ban Nenad; Bukau Bernd
The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins.
Nature structural & molecular biology 2009;16(6):589-97.
2009: Andersson Fredrik I; Tryggvesson Anders; Sharon Michal; Diemand Alexander V; Classen Mirjam; Best Christoph; Schmidt Ronny; Schelin Jenny; Stanne Tara M; Bukau Bernd; Robinson Carol V; Witt Susanne; Mogk Axel; Clarke Adrian K
Structure and function of a novel type of ATP-dependent Clp protease.
The Journal of biological chemistry 2009;284(20):13519-32.
2009: Schmidt Ronny; Zahn Regina; Bukau Bernd; Mogk Axel
ClpS is the recognition component for Escherichia coli substrates of the N-end rule degradation pathway.
Molecular microbiology 2009;72(2):506-17.
2008: Rodriguez Fernanda; Arsène-Ploetze Florence; Rist Wolfgang; Rüdiger Stefan; Schneider-Mergener Jens; Mayer Matthias P; Bukau Bernd
Molecular basis for regulation of the heat shock transcription factor sigma32 by the DnaK and DnaJ chaperones.
Molecular cell 2008;32(3):347-58.
2008: Andréasson Claes; Fiaux Jocelyne; Rampelt Heike; Druffel-Augustin Silke; Bukau Bernd
Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16519-24.
2008: Huber Damon; Bukau Bernd
DegP: a Protein "Death Star".
Structure (London, England : 1993) 2008;16(7):989-90.
2008: Merz Frieder; Boehringer Daniel; Schaffitzel Christiane; Preissler Steffen; Hoffmann Anja; Maier Timm; Rutkowska Anna; Lozza Jasmin; Ban Nenad; Bukau Bernd; Deuerling Elke
Molecular mechanism and structure of Trigger Factor bound to the translating ribosome.
The EMBO journal 2008;27(11):1622-32.
2008: Haslberger Tobias; Zdanowicz Agnieszka; Brand Ingo; Kirstein Janine; Turgay Kürsad; Mogk Axel; Bukau Bernd
Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.
Nature structural & molecular biology 2008;15(6):641-50.
2008: Tessarz Peter; Mogk Axel; Bukau Bernd
Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation.
Molecular microbiology 2008;68(1):87-97.
2008: Erbse Annette H; Wagner Judith N; Truscott Kaye N; Spall Sukhdeep K; Kirstein Janine; Zeth Kornelius; Turgay Kürsad; Mogk Axel; Bukau Bernd; Dougan David A
Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding.
The FEBS journal 2008;275(7):1400-10.
2008: Andréasson Claes; Fiaux Jocelyne; Rampelt Heike; Mayer Matthias P; Bukau Bernd
Hsp110 is a nucleotide-activated exchange factor for Hsp70.
The Journal of biological chemistry 2008;283(14):8877-84.
2008: Bingel-Erlenmeyer Rouven; Kohler Rebecca; Kramer Günter; Sandikci Arzu; Antolic Snjezana; Maier Timm; Schaffitzel Christiane; Wiedmann Brigitte; Bukau Bernd; Ban Nenad
A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing.
Nature 2008;452(7183):108-11.
2008: Mogk Axel; Haslberger Tobias; Tessarz Peter; Bukau Bernd
Common and specific mechanisms of AAA+ proteins involved in protein quality control.
Biochemical Society transactions 2008;36(Pt 1):120-5.
2008: Rutkowska Anna; Mayer Matthias P; Hoffmann Anja; Merz Frieder; Zachmann-Brand Beate; Schaffitzel Christiane; Ban Nenad; Deuerling Elke; Bukau Bernd
Dynamics of trigger factor interaction with translating ribosomes.
The Journal of biological chemistry 2008;283(7):4124-32.
2008: Sadlish Heather; Rampelt Heike; Shorter James; Wegrzyn Renee D; Andréasson Claes; Lindquist Susan; Bukau Bernd
Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities.
PloS one 2008;3(3):e1763.
2007: Mogk Axel; Schmidt Ronny; Bukau Bernd
The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies.
Trends in cell biology 2007;17(4):165-72.
2007: Haslberger Tobias; Weibezahn Jimena; Zahn Regina; Lee Sukyeong; Tsai Francis T F; Bukau Bernd; Mogk Axel
M domains couple the ClpB threading motor with the DnaK chaperone activity.
Molecular cell 2007;25(2):247-60.
2007: de Marco Ario; Deuerling Elke; Mogk Axel; Tomoyasu Toshifumi; Bukau Bernd
Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli.
BMC biotechnology 2007;7():32.
2006: Vogel Markus; Mayer Matthias P; Bukau Bernd
Allosteric regulation of Hsp70 chaperones involves a conserved interdomain linker.
The Journal of biological chemistry 2006;281(50):38705-11.
2006: Merz Frieder; Hoffmann Anja; Rutkowska Anna; Zachmann-Brand Beate; Bukau Bernd; Deuerling Elke
The C-terminal domain of Escherichia coli trigger factor represents the central module of its chaperone activity.
The Journal of biological chemistry 2006;281(42):31963-71.
2006: Raviol Holger; Sadlish Heather; Rodriguez Fernanda; Mayer Matthias P; Bukau Bernd
Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor.
The EMBO journal 2006;25(11):2510-8.
2006: Rist Wolfgang; Graf Christian; Bukau Bernd; Mayer Matthias P
Amide hydrogen exchange reveals conformational changes in hsp70 chaperones important for allosteric regulation.
The Journal of biological chemistry 2006;281(24):16493-501.
2006: Pastore Chiara; Adinolfi Salvatore; Huynen Martjin A; Rybin Vladimir; Martin Stephen; Mayer Mathias; Bukau Bernd; Pastore Annalisa
YfhJ, a molecular adaptor in iron-sulfur cluster formation or a frataxin-like protein?
Structure (London, England : 1993) 2006;14(5):857-67.
2006: Bukau Bernd; Weissman Jonathan; Horwich Arthur
Molecular chaperones and protein quality control.
Cell 2006;125(3):443-51.
2006: Kirstein Janine; Schlothauer Tilman; Dougan David A; Lilie Hauke; Tischendorf Gilbert; Mogk Axel; Bukau Bernd; Turgay Kürsad
Adaptor protein controlled oligomerization activates the AAA+ protein ClpC.
The EMBO journal 2006;25(7):1481-91.
2006: Hoffmann Anja; Merz Frieder; Rutkowska Anna; Zachmann-Brand Beate; Deuerling Elke; Bukau Bernd
Trigger factor forms a protective shield for nascent polypeptides at the ribosome.
The Journal of biological chemistry 2006;281(10):6539-45.
2006: Andersson Fredrik I; Blakytny Robert; Kirstein Janine; Turgay Kürsad; Bukau Bernd; Mogk Axel; Clarke Adrian K
Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity.
The Journal of biological chemistry 2006;281(9):5468-75.
2006: Erbse A; Schmidt R; Bornemann T; Schneider-Mergener J; Mogk A; Zahn R; Dougan D A; Bukau B
ClpS is an essential component of the N-end rule pathway in Escherichia coli.
Nature 2006;439(7077):753-6.
2006: Vogel Markus; Bukau Bernd; Mayer Matthias P
Allosteric regulation of Hsp70 chaperones by a proline switch.
Molecular cell 2006;21(3):359-67.
2006: Raviol Holger; Bukau Bernd; Mayer Matthias P
Human and yeast Hsp110 chaperones exhibit functional differences.
FEBS letters 2006;580(1):168-74.
2005: Weibezahn Jimena; Schlieker Christian; Tessarz Peter; Mogk Axel; Bukau Bernd
Novel insights into the mechanism of chaperone-assisted protein disaggregation.
Biological chemistry 2005;386(8):739-44.
2005: Vorderwülbecke S; Kramer G; Merz F; Kurz T A; Rauch T; Zachmann-Brand B; Bukau B; Deuerling E
Low temperature of GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor DnaK.
FEBS letters 2005;579(15):181-7.
2005: Bukau Bernd
Ribosomes catch Hsp70s.
Nature structural & molecular biology 2005;12(6):472-3.
2005: Mayer M P; Bukau B
Hsp70 chaperones: cellular functions and molecular mechanism.
Cellular and molecular life sciences : CMLS 2005;62(6):670-84.
2004: Schlieker Christian; Tews Ivo; Bukau Bernd; Mogk Axel
Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides.
FEBS letters 2004;578(3):351-6.
2004: Weibezahn Jimena; Tessarz Peter; Schlieker Christian; Zahn Regina; Maglica Zeljka; Lee Sukyeong; Zentgraf Hanswalter; Weber-Ban Eilika U; Dougan David A; Tsai Francis T F; Mogk Axel; Bukau Bernd
Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.
Cell 2004;119(5):653-65.
2004: Becker Thomas; Hritz Jozef; Vogel Markus; Caliebe Alexander; Bukau Bernd; Soll Jürgen; Schleiff Enrico
Toc12, a novel subunit of the intermembrane space preprotein translocon of chloroplasts.
Molecular biology of the cell 2004;15(11):5130-44.
2004: Deuerling Elke; Bukau Bernd
Chaperone-assisted folding of newly synthesized proteins in the cytosol.
Critical reviews in biochemistry and molecular biology 2004;39(5-6):261-77.
2004: Ferbitz Lars; Maier Timm; Patzelt Holger; Bukau Bernd; Deuerling Elke; Ban Nenad
Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.
Nature 2004;431(7008):590-6.
2004: Erbse A; Mayer M P; Bukau B
Mechanism of substrate recognition by Hsp70 chaperones.
Biochemical Society transactions 2004;32(Pt 4):617-21.
2004: Schlieker Christian; Weibezahn Jimena; Patzelt Holger; Tessarz Peter; Strub Christine; Zeth Kornelius; Erbse Annette; Schneider-Mergener Jens; Chin Jason W; Schultz Peter G; Bukau Bernd; Mogk Axel
Substrate recognition by the AAA+ chaperone ClpB.
Nature structural & molecular biology 2004;11(7):607-15.
2004: Brehmer Dirk; Gässler Claudia; Rist Wolfgang; Mayer Matthias P; Bukau Bernd
Influence of GrpE on DnaK-substrate interactions.
The Journal of biological chemistry 2004;279(27):27957-64.
2004: Kramer G; Rutkowska A; Wegrzyn R D; Patzelt H; Kurz T A; Merz F; Rauch T; Vorderwülbecke S; Deuerling E; Bukau B
Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains.
Journal of bacteriology 2004;186(12):3777-84.
2004: Buskiewicz Iwona; Deuerling Elke; Gu Shan-Qing; Jöckel Johannes; Rodnina Marina V; Bukau Bernd; Wintermeyer Wolfgang
Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7902-6.
2004: Schlieker Christian; Mogk Axel; Bukau Bernd
A PDZ switch for a cellular stress response.
Cell 2004;117(4):417-9.
2004: Mogk Axel; Dougan David; Weibezahn Jimena; Schlieker Christian; Turgay Kursad; Bukau Bernd
Broad yet high substrate specificity: the challenge of AAA+ proteins.
Journal of structural biology 2004;146(1-2):90-8.
2004: Kramer Günter; Patzelt Holger; Rauch Thomas; Kurz Thorben A; Vorderwülbecke Sonja; Bukau Bernd; Deuerling Elke
Trigger factor peptidyl-prolyl cis/trans isomerase activity is not essential for the folding of cytosolic proteins in Escherichia coli.
The Journal of biological chemistry 2004;279(14):14165-70.
2004: Vorderwülbecke S; Kramer G; Merz F; Kurz T A; Rauch T; Zachmann-Brand B; Bukau B; Deuerling E
Low temperature or GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor and DnaK.
FEBS letters 2004;559(1-3):181-7.
2004: Mogk Axel; Bukau Bernd
Molecular chaperones: structure of a protein disaggregase.
Current biology : CB 2004;14(2):R78-80.
2004: Nikolay Rainer; Wiederkehr Thomas; Rist Wolfgang; Kramer Günter; Mayer Matthias P; Bukau Bernd
Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity.
The Journal of biological chemistry 2004;279(4):2673-8.
2003: Rist Wolfgang; Jørgensen Thomas J D; Roepstorff Peter; Bukau Bernd; Mayer Matthias P
Mapping temperature-induced conformational changes in the Escherichia coli heat shock transcription factor sigma 32 by amide hydrogen exchange.
The Journal of biological chemistry 2003;278(51):51415-21.
2003: Mogk Axel; Deuerling Elke; Vorderwülbecke Sonja; Vierling Elizabeth; Bukau Bernd
Small heat shock proteins, ClpB and the DnaK system form a functional triade in reversing protein aggregation.
Molecular microbiology 2003;50(2):585-95.
2003: Strub Christine; Schlieker Christian; Bukau Bernd; Mogk Axel
Poly-L-lysine enhances the protein disaggregation activity of ClpB.
FEBS letters 2003;553(1-2):125-30.
2003: Hengge Regine; Bukau Bernd
Proteolysis in prokaryotes: protein quality control and regulatory principles.
Molecular microbiology 2003;49(6):1451-62.
2003: Dougan David A; Weber-Ban Eilika; Bukau Bernd
Targeted delivery of an ssrA-tagged substrate by the adaptor protein SspB to its cognate AAA+ protein ClpX.
Molecular cell 2003;12(2):373-80.
2003: Weibezahn Jimena; Schlieker Christian; Bukau Bernd; Mogk Axel
Characterization of a trap mutant of the AAA+ chaperone ClpB.
The Journal of biological chemistry 2003;278(35):32608-17.
2003: Mogk Axel; Schlieker Christian; Friedrich Kenneth L; Schönfeld Hans-Joachim; Vierling Elizabeth; Bukau Bernd
Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.
The Journal of biological chemistry 2003;278(33):31033-42.
2003: Mogk Axel; Schlieker Christian; Strub Christine; Rist Wolfgang; Weibezahn Jimena; Bukau Bernd
Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity.
The Journal of biological chemistry 2003;278(20):17615-24.
2003: Deuerling Elke; Patzelt Holger; Vorderwülbecke Sonja; Rauch Thomas; Kramer Günter; Schaffitzel Elke; Mogk Axel; Schulze-Specking Agnes; Langen Hanno; Bukau Bernd
Trigger Factor and DnaK possess overlapping substrate pools and binding specificities.
Molecular microbiology 2003;47(5):1317-28.
2003: Schlothauer Tilman; Mogk Axel; Dougan David A; Bukau Bernd; Turgay Kürsad
MecA, an adaptor protein necessary for ClpC chaperone activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2306-11.
2003: Erbse Annette; Dougan David A; Bukau Bernd
A folding machine for many but a master of none.
Nature structural biology 2003;10(2):84-6.
2002: Mayer Matthias P; Nikolay Rainer; Bukau Bernd
Aha, another regulator for hsp90 chaperones.
Molecular cell 2002;10(6):1255-6.
2002: Zeth Kornelius; Ravelli Raimond B; Paal Klaus; Cusack Stephen; Bukau Bernd; Dougan David A
Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA.
Nature structural biology 2002;9(12):906-11.
2002: Dougan D A; Mogk A; Bukau B
Protein folding and degradation in bacteria: to degrade or not to degrade? That is the question.
Cellular and molecular life sciences : CMLS 2002;59(10):1607-16.
2002: Patzelt Holger; Kramer Günter; Rauch Thomas; Schönfeld Hans-Joachim; Bukau Bernd; Deuerling Elke
Three-state equilibrium of Escherichia coli trigger factor.
Biological chemistry 2002;383(10):1611-9.
2002: Dougan David A; Mogk Axel; Zeth Kornelius; Turgay Kürsad; Bukau Bernd
AAA+ proteins and substrate recognition, it all depends on their partner in crime.
FEBS letters 2002;529(1):6-10.
2002: Kluck Christoph J; Patzelt Holger; Genevaux Pierre; Brehmer Dirk; Rist Wolfgang; Schneider-Mergener Jens; Bukau Bernd; Mayer Matthias P
Structure-function analysis of HscC, the Escherichia coli member of a novel subfamily of specialized Hsp70 chaperones.
The Journal of biological chemistry 2002;277(43):41060-9.
2002: Kramer Günter; Rauch Thomas; Rist Wolfgang; Vorderwülbecke Sonja; Patzelt Holger; Schulze-Specking Agnes; Ban Nenad; Deuerling Elke; Bukau Bernd
L23 protein functions as a chaperone docking site on the ribosome.
Nature 2002;419(6903):171-4.
2002: Mayer Matthias P; Tomoyasu Toshifumi; Bukau Bernd
[Molecular mechanism of Hsp70 chaperones]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(9):1189-95.
2002: Zeth Kornelius; Dougan David A; Cusack Stephen; Bukau Bernd; Ravelli Raimond B
Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 7):1207-10.
2002: Schlieker Christian; Bukau Bernd; Mogk Axel
Prevention and reversion of protein aggregation by molecular chaperones in the E. coli cytosol: implications for their applicability in biotechnology.
Journal of biotechnology 2002;96(1):13-21.
2002: Dougan David A; Reid Brian G; Horwich Arthur L; Bukau Bernd
ClpS, a substrate modulator of the ClpAP machine.
Molecular cell 2002;9(3):673-83.
2002: Wiederkehr T; Bukau B; Buchberger A
Protein turnover: a CHIP programmed for proteolysis.
Current biology : CB 2002;12(1):R26-8.
2001: Patzelt H; Rüdiger S; Brehmer D; Kramer G; Vorderwülbecke S; Schaffitzel E; Waitz A; Hesterkamp T; Dong L; Schneider-Mergener J; Bukau B; Deuerling E
Binding specificity of Escherichia coli trigger factor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14244-9.
2001: Tomoyasu T; Arsène F; Ogura T; Bukau B
The C terminus of sigma(32) is not essential for degradation by FtsH.
Journal of bacteriology 2001;183(20):5911-7.
2001: Schaffitzel E; Rüdiger S; Bukau B; Deuerling E
Functional dissection of trigger factor and DnaK: interactions with nascent polypeptides and thermally denatured proteins.
Biological chemistry 2001;382(8):1235-43.
2001: Gassler C S; Wiederkehr T; Brehmer D; Bukau B; Mayer M P
Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor.
The Journal of biological chemistry 2001;276(35):32538-44.
2001: Brehmer D; Rüdiger S; Gässler C S; Klostermeier D; Packschies L; Reinstein J; Mayer M P; Bukau B
Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange.
Nature structural biology 2001;8(5):427-32.
2001: Tomoyasu T; Mogk A; Langen H; Goloubinoff P; Bukau B
Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol.
Molecular microbiology 2001;40(2):397-413.
2001: Rüdiger S; Schneider-Mergener J; Bukau B
Its substrate specificity characterizes the DnaJ co-chaperone as a scanning factor for the DnaK chaperone.
The EMBO journal 2001;20(5):1042-50.
2001: Mayer M P; Brehmer D; Gässler C S; Bukau B
Hsp70 chaperone machines.
Advances in protein chemistry 2001;59():1-44.
2000: Rüdiger S; Mayer M P; Schneider-Mergener J; Bukau B
Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch.
Journal of molecular biology 2000;304(3):245-51.
2000: Mayer M P; Rüdiger S; Bukau B
Molecular basis for interactions of the DnaK chaperone with substrates.
Biological chemistry 2000;381(9-10):877-85.
2000: Mayer M P; Schröder H; Rüdiger S; Paal K; Laufen T; Bukau B
Multistep mechanism of substrate binding determines chaperone activity of Hsp70.
Nature structural biology 2000;7(7):586-93.
2000: Arsène F; Tomoyasu T; Bukau B
The heat shock response of Escherichia coli.
International journal of food microbiology 2000;55(1-3):3-9.
2000: Bukau B; Deuerling E; Pfund C; Craig E A
Getting newly synthesized proteins into shape.
Cell 2000;101(2):119-22.
1999: Buchberger A; Gässler C S; Büttner M; McMacken R; Bukau B
Functional defects of the DnaK756 mutant chaperone of Escherichia coli indicate distinct roles for amino- and carboxyl-terminal residues in substrate and co-chaperone interaction and interdomain communication.
The Journal of biological chemistry 1999;274(53):38017-26.
1999: Mogk A; Tomoyasu T; Goloubinoff P; Rüdiger S; Röder D; Langen H; Bukau B
Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB.
The EMBO journal 1999;18(24):6934-49.
1999: Knoblauch N T; Rüdiger S; Schönfeld H J; Driessen A J; Schneider-Mergener J; Bukau B
Substrate specificity of the SecB chaperone.
The Journal of biological chemistry 1999;274(48):34219-25.
1999: Deuerling E; Schulze-Specking A; Tomoyasu T; Mogk A; Bukau B
Trigger factor and DnaK cooperate in folding of newly synthesized proteins.
Nature 1999;400(6745):693-6.
1999: Mayer M P; Laufen T; Paal K; McCarty J S; Bukau B
Investigation of the interaction between DnaK and DnaJ by surface plasmon resonance spectroscopy.
Journal of molecular biology 1999;289(4):1131-44.
1999: Arsène F; Tomoyasu T; Mogk A; Schirra C; Schulze-Specking A; Bukau B
Role of region C in regulation of the heat shock gene-specific sigma factor of Escherichia coli, sigma32.
Journal of bacteriology 1999;181(11):3552-61.
1999: Brix J; Rüdiger S; Bukau B; Schneider-Mergener J; Pfanner N
Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein.
The Journal of biological chemistry 1999;274(23):16522-30.
1999: Mayer M P; Bukau B
Molecular chaperones: the busy life of Hsp90.
Current biology : CB 1999;9(9):R322-5.
1999: Laufen T; Mayer M P; Beisel C; Klostermeier D; Mogk A; Reinstein J; Bukau B
Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5452-7.
1998: Gässler C S; Buchberger A; Laufen T; Mayer M P; Schröder H; Valencia A; Bukau B
Mutations in the DnaK chaperone affecting interaction with the DnaJ cochaperone.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15229-34.
1998: Tatsuta T; Tomoyasu T; Bukau B; Kitagawa M; Mori H; Karata K; Ogura T
Heat shock regulation in the ftsH null mutant of Escherichia coli: dissection of stability and activity control mechanisms of sigma32 in vivo.
Molecular microbiology 1998;30(3):583-93.
1998: Tomoyasu T; Ogura T; Tatsuta T; Bukau B
Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli.
Molecular microbiology 1998;30(3):567-81.
1998: Hesterkamp T; Bukau B
Role of the DnaK and HscA homologs of Hsp70 chaperones in protein folding in E.coli.
The EMBO journal 1998;17(16):4818-28.
1998: Mayer M P; Bukau B
Hsp70 chaperone systems: diversity of cellular functions and mechanism of action.
Biological chemistry 1998;379(3):261-8.
1998: Bukau B; Horwich A L
The Hsp70 and Hsp60 chaperone machines.
Cell 1998;92(3):351-66.
1997: Terada K; Kanazawa M; Bukau B; Mori M
The human DnaJ homologue dj2 facilitates mitochondrial protein import and luciferase refolding.
The Journal of cell biology 1997;139(5):1089-95.
1997: Hesterkamp T; Deuerling E; Bukau B
The amino-terminal 118 amino acids of Escherichia coli trigger factor constitute a domain that is necessary and sufficient for binding to ribosomes.
The Journal of biological chemistry 1997;272(35):21865-71.
1997: Rüdiger S; Buchberger A; Bukau B
Interaction of Hsp70 chaperones with substrates.
Nature structural biology 1997;4(5):342-9.
1997: Rüdiger S; Germeroth L; Schneider-Mergener J; Bukau B
Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries.
The EMBO journal 1997;16(7):1501-7.
1997: Packschies L; Theyssen H; Buchberger A; Bukau B; Goody R S; Reinstein J
GrpE accelerates nucleotide exchange of the molecular chaperone DnaK with an associative displacement mechanism.
Biochemistry 1997;36(12):3417-22.
1996: Bukau B; Hesterkamp T; Luirink J
Growing up in a dangerous environment: a network of multiple targeting and folding pathways for nascent polypeptides in the cytosol.
Trends in cell biology 1996;6(12):480-6.
1996: Theyssen H; Schuster H P; Packschies L; Bukau B; Reinstein J
The second step of ATP binding to DnaK induces peptide release.
Journal of molecular biology 1996;263(5):657-70.
1996: Buchberger A; Schröder H; Hesterkamp T; Schönfeld H J; Bukau B
Substrate shuttling between the DnaK and GroEL systems indicates a chaperone network promoting protein folding.
Journal of molecular biology 1996;261(3):328-33.
1996: Hesterkamp T; Bukau B
The Escherichia coli trigger factor.
FEBS letters 1996;389(1):32-4.
1996: Hesterkamp T; Bukau B
Identification of the prolyl isomerase domain of Escherichia coli trigger factor.
FEBS letters 1996;385(1-2):67-71.
1996: Hesterkamp T; Hauser S; Lütcke H; Bukau B
Escherichia coli trigger factor is a prolyl isomerase that associates with nascent polypeptide chains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4437-41.
1996: McCarty J S; Rüdiger S; Schönfeld H J; Schneider-Mergener J; Nakahigashi K; Yura T; Bukau B
Regulatory region C of the E. coli heat shock transcription factor, sigma32, constitutes a DnaK binding site and is conserved among eubacteria.
Journal of molecular biology 1996;256(5):829-37.
1996: Gamer J; Multhaup G; Tomoyasu T; McCarty J S; Rüdiger S; Schönfeld H J; Schirra C; Bujard H; Bukau B
A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32.
The EMBO journal 1996;15(3):607-17.
1995: Buchberger A; Theyssen H; Schröder H; McCarty J S; Virgallita G; Milkereit P; Reinstein J; Bukau B
Nucleotide-induced conformational changes in the ATPase and substrate binding domains of the DnaK chaperone provide evidence for interdomain communication.
The Journal of biological chemistry 1995;270(28):16903-10.
1995: Tomoyasu T; Gamer J; Bukau B; Kanemori M; Mori H; Rutman A J; Oppenheim A B; Yura T; Yamanaka K; Niki H
Escherichia coli FtsH is a membrane-bound, ATP-dependent protease which degrades the heat-shock transcription factor sigma 32.
The EMBO journal 1995;14(11):2551-60.
1995: McCarty J S; Buchberger A; Reinstein J; Bukau B
The role of ATP in the functional cycle of the DnaK chaperone system.
Journal of molecular biology 1995;249(1):126-37.
1995: Schönfeld H J; Schmidt D; Schröder H; Bukau B
The DnaK chaperone system of Escherichia coli: quaternary structures and interactions of the DnaK and GrpE components.
The Journal of biological chemistry 1995;270(5):2183-9.
1994: Szabo A; Langer T; Schröder H; Flanagan J; Bukau B; Hartl F U
The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10345-9.
1994: Buchberger A; Valencia A; McMacken R; Sander C; Bukau B
The chaperone function of DnaK requires the coupling of ATPase activity with substrate binding through residue E171.
The EMBO journal 1994;13(7):1687-95.
1994: Buchberger A; Schröder H; Büttner M; Valencia A; Bukau B
A conserved loop in the ATPase domain of the DnaK chaperone is essential for stable binding of GrpE.
Nature structural biology 1994;1(2):95-101.
1993: Schröder H; Langer T; Hartl F U; Bukau B
DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.
The EMBO journal 1993;12(11):4137-44.
1993: Bukau B
Regulation of the Escherichia coli heat-shock response.
Molecular microbiology 1993;9(4):671-80.
1992: Gamer J; Bujard H; Bukau B
Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor sigma 32.
Cell 1992;69(5):833-42.

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