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Alun HUGHES

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C Park; Angela C Shore; W D Strain; Therese Tillin; R Bathula; Nish Chaturvedi; Alun HUGHES
Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors.
Valentina O Puntmann; Bernhard Schnackenburg; Phil Chowienczyk; Nicholas Gaddum; Rolf Gebker; Alun HUGHES; Cosima Jahnke; Jesus Mirelis; Eike Nagel; Ingo Paetsch; Eckart Fleck
Gender-specific differences in myocardial deformation and aortic stiffness at rest and dobutamine stress.
Charlotte H Manisty; Jamil Mayet; Punam A Pabari; Beth Unsworth; Zachary I Whinnett; Ali Al-Hussaini; Resham Baruah; Alun HUGHES; Darrel P Francis
The acute effects of changes to AV delay on BP and stroke volume: potential implications for design of pacemaker optimization protocols.

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All Publications

2012: C Park; Angela C Shore; W D Strain; Therese Tillin; R Bathula; Nish Chaturvedi; Alun HUGHES
Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors.
Atherosclerosis 2012;221(2):503-7.
2012: Valentina O Puntmann; Bernhard Schnackenburg; Phil Chowienczyk; Nicholas Gaddum; Rolf Gebker; Alun HUGHES; Cosima Jahnke; Jesus Mirelis; Eike Nagel; Ingo Paetsch; Eckart Fleck
Gender-specific differences in myocardial deformation and aortic stiffness at rest and dobutamine stress.
Hypertension 2012;59(3):712-8.
2012: Charlotte H Manisty; Jamil Mayet; Punam A Pabari; Beth Unsworth; Zachary I Whinnett; Ali Al-Hussaini; Resham Baruah; Alun HUGHES; Darrel P Francis
The acute effects of changes to AV delay on BP and stroke volume: potential implications for design of pacemaker optimization protocols.
Circulation. Arrhythmia and electrophysiology 2012;5(1):122-30.
2012: D Liu; Simon A McG Thom; Nicholas Witt; Nigel B Wood; Alun HUGHES; X Yun Xu
Assessment of energy requirement for the retinal arterial network in normal and hypertensive subjects.
Journal of biomechanical engineering 2012;134(1):014501.
2011: Edgaras Stankevicius; Lilliana Beck; Ebbe Boedtkjer; Thomas Dalsgaard; Alun HUGHES; Christel Kroigaard; Mikkel W Misfeldt; Gorm Nielsen; Olav Schjorring; Simonsen Ulf
Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat.
The Journal of pharmacology and experimental therapeutics 2011;339(3):842-50.
2011: Mirian J Starmans-Kool; Alice V Stanton; Yun Y Xu; Simon A McG Thom; Kim H Parker; Alun HUGHES
High dietary salt intake increases carotid blood pressure and wave reflection in normotensive healthy young men.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;110(2):468-71.
2010: R Bathula; Alun HUGHES; R Panerai; J Potter; Simon A McG Thom; Darrel P Francis; Angela C Shore; Jaspal S Kooner; Nish Chaturvedi
Indian Asians have poorer cardiovascular autonomic function than Europeans: this is due to greater hyperglycaemia and may contribute to their greater risk of heart disease.
Diabetologia 2010;53(10):2120-8.
2010: Aya Mostafa; Mostafa K Mohamed; Mohamed Saeed; Abubakr Hasan; Arnaud Fontanet; Ian Godsland; Emma Coady; Gamal Esmat; Mostafa El-Hoseiny; Mohamed Abdul-Hamid; Alun HUGHES; Nish Chaturvedi
Hepatitis C infection and clearance: impact on atherosclerosis and cardiometabolic risk factors.
Gut 2010;59(8):1135-40.
2010: Charlotte H Manisty; Jamil Mayet; Robyn J Tapp; Kim H Parker; Peter S Sever; Neil R Poulter; Neil H Poulter; Simon A McG Thom; Alun HUGHES
Wave reflection predicts cardiovascular events in hypertensive individuals independent of blood pressure and other cardiovascular risk factors: an ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) substudy.
Journal of the American College of Cardiology 2010;56(1):24-30.
2009: D Liu; Nigel B Wood; Nicholas Witt; Alun HUGHES; Simon A McG Thom; X Yun Xu
Computational analysis of oxygen transport in the retinal arterial network.
Current eye research 2009;34(11):945-56.
2009: Attila Kun; Vladimir V Matchkov; Edgaras Stankevicius; A Nardi; Alun HUGHES; H J Kirkeby; J Demnitz; Simonsen Ulf
NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats.
British journal of pharmacology 2009;158(6):1465-76.
2009: Charlotte H Manisty; Jamil Mayet; Robyn J Tapp; Peter S Sever; Neil Poulter; Simon A McG Thom; Alun HUGHES
Atorvastatin treatment is associated with less augmentation of the carotid pressure waveform in hypertension: a substudy of the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT).
Hypertension 2009;54(5):1009-13.
2009: Charlotte H Manisty; Andrew Zambanini; Kim H Parker; Justin E Davies; Darrel P Francis; Jamil Mayet; Simon A McG Thom; Alun HUGHES
Differences in the magnitude of wave reflection account for differential effects of amlodipine- versus atenolol-based regimens on central blood pressure: an Anglo-Scandinavian Cardiac Outcome Trial substudy.
Hypertension 2009;54(4):724-30.
2009: Joline W J Beulens; A Patel; Johannes Vingerling; J Kennedy Cruickshank; Alun HUGHES; Alice Stanton; J Lu; S A McG Thom; Diederick Grobbee; Ronald P Stolk
Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial.
Diabetologia 2009;52(10):2027-36.
2009: Simon Thom; Christoph Stettler; Alice Stanton; Nicholas Witt; Robyn Tapp; Nish Chaturvedi; Sabin Allemann; Jamil Mayet; Peter S Sever; Neil Poulter; Eoin O'Brien; Alun HUGHES
Differential effects of antihypertensive treatment on the retinal microcirculation: an anglo-scandinavian cardiac outcomes trial substudy.
Hypertension 2009;54(2):405-8.
2009: R Torii; Jennifer Keegan; Nigel B Wood; A W Dowsey; Alun HUGHES; Guang-Zhong Yang; David N Firmin; Simon A McG Thom; X Yun Xu
The effect of dynamic vessel motion on haemodynamic parameters in the right coronary artery: a combined MR and CFD study.
The British journal of radiology 2009;82 Spec No 1():S24-32.
2009: Nanfeng Sun; J H Leung; Nigel B Wood; Alun HUGHES; Simon A McG Thom; N J Cheshire; X Yun Xu
Computational analysis of oxygen transport in a patient-specific model of abdominal aortic aneurysm with intraluminal thrombus.
The British journal of radiology 2009;82 Spec No 1():S18-23.
2008: F P P Tan; G Soloperto; S Bashford; Nigel B Wood; Simon Thom; Alun HUGHES; X Yun Xu
Analysis of flow disturbance in a stenosed carotid artery bifurcation using two-equation transitional and turbulence models.
Journal of biomechanical engineering 2008;130(6):061008.
2008: Justin E Davies; Kim H Parker; Darrel P Francis; Alun HUGHES; Jamil Mayet
What is the role of the aorta in directing coronary blood flow?
Heart (British Cardiac Society) 2008;94(12):1545-7.
2008: Therese Tillin; Harshil Dhutia; John Chambers; Iqbal Malik; Emma Coady; Jamil Mayet; Andrew R Wright; Jaspal S Kooner; Angela Shore; Simon Thom; Nish Chaturvedi; Alun HUGHES
South Asian men have different patterns of coronary artery disease when compared with European men.
International journal of cardiology 2008;129(3):406-13.
2008: Zachary I Whinnett; Justin E R Davies; Gemma Nott; Keith Willson; Charlotte H Manisty; Nicholas S Peters; Prapa Kanagaratnam; D Wyn Davies; Alun HUGHES; Jamil Mayet; Darrel P Francis
Efficiency, reproducibility and agreement of five different hemodynamic measures for optimization of cardiac resynchronization therapy.
International journal of cardiology 2008;129(2):216-26.
2008: Andrew Sharp; Robyn Tapp; Darrel P Francis; Simon A McG Thom; Alun HUGHES; Alice V Stanton; Andrew Zambanini; Nish Chaturvedi; Sheila Byrd; Neil R Poulter; Peter S Sever; Jamil Mayet
Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy.
Journal of the American College of Cardiology 2008;52(12):1015-21.
2008: Nearchos Hadjiloizou; Justin E Davies; Iqbal S Malik; Jazmin Aguado-Sierra; Keith Willson; Rodney A Foale; Kim H Parker; Alun HUGHES; Darrel P Francis; Jamil Mayet
Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery.
American journal of physiology. Heart and circulatory physiology 2008;295(3):H1198-H1205.
2008: Therese Tillin; R M Evans; Nicholas Witt; P S Sharp; Paul M McKeigue; Nish Chaturvedi; Alun HUGHES
Ethnic differences in retinal microvascular structure.
Diabetologia 2008;51(9):1719-22.
2008: Alun HUGHES; Alice V Stanton; Atif S Jabbar; Neil Chapman; M Elena Martinez-Perez; Simon A McG Thom
Effect of antihypertensive treatment on retinal microvascular changes in hypertension.
Journal of hypertension 2008;26(8):1703-7.
2008: Charlotte H Manisty; Keith Willson; Justin E R Davies; Zachary I Whinnett; Resham Baruah; Yoseph Mebrate; Prapa Kanagaratnam; Nicholas S Peters; Alun HUGHES; Jamil Mayet; Darrel P Francis
Induction of oscillatory ventilation pattern using dynamic modulation of heart rate through a pacemaker.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(1):R219-27.
2008: Alun HUGHES; Justin E Davies; Darrel Francis; Jamil Mayet; Kim H Parker
Peripheral augmentation index and wave reflection in the radial artery.
Hypertension 2008;51(6):e45-6; author reply e47.
2008: Steven P Downie; Sheila M Raynor; David N Firmin; Nigel B Wood; Simon A McG Thom; Alun HUGHES; Kim H Parker; John H N Wolfe; X Yun Xu
Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf.
American journal of physiology. Heart and circulatory physiology 2008;294(5):H2112-20.
2008: M Achour; X Jacq; Philippe Rondé; M Alhosin; C Charlot; Thierry Chataigneau; M Jeanblanc; M Macaluso; A Giordano; Alun HUGHES; Valérie B Schini-Kerth; Christian BRONNER
The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression.
Oncogene 2008;27(15):2187-97.
2008: Rajaram Bathula; Darrel P Francis; Alun HUGHES; Nish Chaturvedi
Ethnic differences in heart rate: can these be explained by conventional cardiovascular risk factors?
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2008;18(2):90-5.
2008: Ronald P Stolk; Mary J van Schooneveld; J Kennedy Cruickshank; Alun HUGHES; Alice Stanton; Juming Lu; Anushka Patel; Simon A McG Thom; Diederick Grobbee; Johannes Vingerling
Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements (AdRem) study.
Diabetes care 2008;31(4):708-13.
2008: Zachary I Whinnett; Cathy Briscoe; Justin E R Davies; Keith Willson; Charlotte H Manisty; D Wyn Davies; Nicholas S Peters; Prapa Kanagaratnam; Alun HUGHES; Jamil Mayet; Darrel P Francis
The atrioventricular delay of cardiac resynchronization can be optimized hemodynamically during exercise and predicted from resting measurements.
Heart rhythm : the official journal of the Heart Rhythm Society 2008;5(3):378-86.
2007: Rory B McGoldrick; Martyn Kingsbury; Mark A Turner; Desmond J Sheridan; Alun HUGHES
Left ventricular hypertrophy induced by aortic banding impairs relaxation of isolated coronary arteries.
Clinical science (London, England : 1979) 2007;113(12):473-8.
2007: Awahan Rahman; Alun HUGHES; Vladimir V Matchkov; Holger Nilsson; Christian Aalkjaer
Antiphase oscillations of endothelium and smooth muscle [Ca2+]i in vasomotion of rat mesenteric small arteries.
Cell calcium 2007;42(6):536-47.
2007: Robyn J Tapp; Cathy Williams; Nicholas Witt; Nish Chaturvedi; Richard Evans; Simon A McG Thom; Alun HUGHES; Andrew Ness
Impact of size at birth on the microvasculature: the Avon Longitudinal Study of Parents and Children.
Pediatrics 2007;120(5):e1225-8.
2007: O Dotsenko; Nish Chaturvedi; Simon A McG Thom; Andrew R Wright; Jamil Mayet; Angela C Shore; Casper G Schalkwijk; Alun HUGHES
Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men.
Journal of thrombosis and haemostasis : JTH 2007;5(10):2036-42.
2007: Nanfeng Sun; Nigel B Wood; Alun HUGHES; Simon A McG Thom; X Yun Xu
Influence of pulsatile flow on LDL transport in the arterial wall.
Annals of biomedical engineering 2007;35(10):1782-90.
2007: Sumangali Wijetunge; Alun HUGHES
Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus.
Journal of hypertension 2007;25(9):1871-8.
2007: Alex Augst; Ben Ariff; Simon A McG Thom; X Yun Xu; Alun HUGHES
Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H1031-7.
2007: Steven P Downie; David N Firmin; Nigel B Wood; Simon A McG Thom; Alun HUGHES; John N H Wolfe; X Yun Xu
Role of MRI in investigating the effects of elastic compression stockings on the deformation of the superficial and deep veins in the lower leg.
Journal of magnetic resonance imaging : JMRI 2007;26(1):80-5.
2007: Sarah A Hope; Alun HUGHES
Drug effects on the mechanical properties of large arteries in humans.
Clinical and experimental pharmacology & physiology 2007;34(7):688-93.
2007: Stephanie L Curtis; Andrew Zambanini; Jamil Mayet; Simon A McG Thom; Rodney A Foale; Kim H Parker; Alun HUGHES
Reduced systolic wave generation and increased peripheral wave reflection in chronic heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H557-62.
2007: Nish Chaturvedi; Emma Coady; Jamil Mayet; Andrew R Wright; Angela C Shore; Sheila Byrd; Simon A McG Thom; Jaspal S Kooner; Casper G Schalkwijk; Alun HUGHES
Indian Asian men have less peripheral arterial disease than European men for equivalent levels of coronary disease.
Atherosclerosis 2007;193(1):204-12.
2007: Nanfeng Sun; Nigel B Wood; Alun HUGHES; Simon A McG Thom; X Yun Xu
Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model.
American journal of physiology. Heart and circulatory physiology 2007;292(6):H3148-57.
2007: Matthijs Kox; Sumangali Wijetunge; Peter Pickkers; Alun HUGHES
Inhibition of Src family tyrosine kinases prevents lipopolysaccharide-induced hyporeactivity in isolated rat tail arteries.
Vascular pharmacology 2007;46(3):195-200.
2007: Therese Tillin; John Chambers; Iqbal S Malik; Emma Coady; Sheila Byrd; Jamil Mayet; Andrew R Wright; Jaspal S Kooner; Angela C Shore; Simon Thom; Nish Chaturvedi; Alun HUGHES
Measurement of pulse wave velocity: site matters.
Journal of hypertension 2007;25(2):383-9.
2007: M Elena Martinez-Perez; Alun HUGHES; Simon A McG Thom; Anil A Bharath; Kim H Parker
Segmentation of blood vessels from red-free and fluorescein retinal images.
Medical image analysis 2007;11(1):47-61.
2007: M Elena Martinez-Perez; Alun HUGHES; Simon A Thom; Kim H Parker
Improvement of a retinal blood vessel segmentation method using the Insight Segmentation and Registration Toolkit (ITK).
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2007;2007():892-5.
2007: Ryo Torii; Nigel B Wood; Alun HUGHES; Simon A McG Thom; Jazmin Aguado-Sierra; Justin E Davies; Darrel P Francis; Kim H Parker; X Yun Xu
A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model.
Journal of biomechanics 2007;40(11):2501-9.
2007: Alun HUGHES; Emma Coady; S Raynor; Jamil Mayet; Andrew R Wright; Angela C Shore; Jaspal S Kooner; Simon A McG Thom; Nish Chaturvedi
Reduced endothelial progenitor cells in European and South Asian men with atherosclerosis.
European journal of clinical investigation 2007;37(1):35-41.
2007: Ronald P Stolk; Johannes Vingerling; J Kennedy Cruickshank; Alun HUGHES; Alice Stanton; Lu Juming; Anushka Patel; Simon A McG Thom; Diederick Grobbee
Rationale and design of the AdRem study: evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus.
Contemporary clinical trials 2007;28(1):6-17.
2006: Edgaras Stankevicius; V Lopez-Valverde; L Rivera; Alun HUGHES; Michael J Mulvany; Simonsen Ulf
Combination of Ca2+ -activated K+ channel blockers inhibits acetylcholine-evoked nitric oxide release in rat superior mesenteric artery.
British journal of pharmacology 2006;149(5):560-72.
2006: Nigel B Wood; SZ Zhao; Andrew Zambanini; M Jackson; W Gedroyc; Simon A McG Thom; Alun HUGHES; X Yun Xu
Curvature and tortuosity of the superficial femoral artery: a possible risk factor for peripheral arterial disease.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;101(5):1412-8.
2006: Zachary I Whinnett; J E R Davies; Keith Willson; Charlotte H Manisty; Anthony W C Chow; Rodney A Foale; D Wyn Davies; Alun HUGHES; Jamil Mayet; Darrel P Francis
Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay.
Heart (British Cardiac Society) 2006;92(11):1628-34.
2006: Ben Ariff; Andrew Zambanini; Sarita Vamadeva; Dean C Barratt; Yun Xu; Peter S Sever; Alice Stanton; Alun HUGHES; Simon Thom
Candesartan- and atenolol-based treatments induce different patterns of carotid artery and left ventricular remodeling in hypertension.
Stroke; a journal of cerebral circulation 2006;37(9):2381-4.
2006: Nanfeng Sun; Nigel B Wood; Alun HUGHES; Simon A McG Thom; X Yun Xu
Fluid-wall modelling of mass transfer in an axisymmetric stenosis: effects of shear-dependent transport properties.
Annals of biomedical engineering 2006;34(7):1119-28.
2006: Neil Poulter; Alun HUGHES; Bryan Williams; Adrian J B Brady; Gordon T McInnes
Angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers. A mini-symposium held at the British Hypertension Society Meeting, September 2005.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2006;7(2):104-21.
2006: Robinder S Garcha; Alun HUGHES
CNP, but not ANP or BNP, relax human isolated subcutaneous resistance arteries by an action involving cyclic GMP and BKCa channels.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2006;7(2):87-91.
2006: Zachary I Whinnett; Justin E R Davies; Keith Willson; Anthony W C Chow; Rodney A Foale; D Wyn Davies; Alun HUGHES; Darrel P Francis; Jamil Mayet
Determination of optimal atrioventricular delay for cardiac resynchronization therapy using acute non-invasive blood pressure.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2006;8(5):358-66.
2006: Alun HUGHES; Elena Martinez-Perez; Abu-Sufian Jabbar; Assif Hassan; Nicholas Witt; Paresh D Mistry; Neil Chapman; Alice V Stanton; Gareth Beevers; Roberto Pedrinelli; Kim H Parker; Simon A McG Thom
Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension.
Journal of hypertension 2006;24(5):889-94.
2006: Nicholas Witt; Tien Y Wong; Alun HUGHES; Nish Chaturvedi; Barbara E Klein; Richard Evans; Mary McNamara; Simon A McG Thom; Ronald Klein
Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke.
Hypertension 2006;47(5):975-81.
2006: Justin E Davies; Zachary I Whinnett; Darrel P Francis; Charlotte H Manisty; Jazmin Aguado-Sierra; Keith Willson; Rodney A Foale; Iqbal S Malik; Alun HUGHES; Kim H Parker; Jamil Mayet
Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy.
Circulation 2006;113(14):1768-78.
2006: Bryan Williams; Peter S Lacy; Simon M Thom; Kennedy Cruickshank; Alice Stanton; David Collier; Alun HUGHES; H Thurston; Michael O'Rourke
Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study.
Circulation 2006;113(9):1213-25.
2006: Justin E Davies; Zachary I Whinnett; Darrel P Francis; Keith Willson; Rodney A Foale; Iqbal S Malik; Alun HUGHES; Kim H Parker; Jamil Mayet
Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H878-85.
2006: Jazmin Aguado-Sierra; Kim H Parker; Justin E Davies; D Francis; Alun HUGHES; Jamil Mayet
Arterial pulse wave velocity in coronary arteries.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2006;1():867-70.
2006: James H Leung; Andrew R Wright; N J W Cheshire; Jeremy Crane; Simon A McG Thom; Alun HUGHES; Yun Xu
Fluid structure interaction of patient specific abdominal aortic aneurysms: a comparison with solid stress models.
Biomedical engineering online 2006;5():33.
2006: Jamila Ibrahim; Bradford C Berk; Alun HUGHES
Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2006;28(1):57-72.
2005: Mahendra K Patel; Gerard F Clunn; Joanne S Lymn; Oneka Austin; Alun HUGHES
Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells.
British journal of pharmacology 2005;145(6):811-7.
2005: Andrew Zambanini; S L Cunningham; Kim H Parker; Ashraf W Khir; Simon A McG Thom; Alun HUGHES
Wave-energy patterns in carotid, brachial, and radial arteries: a noninvasive approach using wave-intensity analysis.
American journal of physiology. Heart and circulatory physiology 2005;289(1):H270-6.
2005: Fadi P Glor; Ben Ariff; Alun HUGHES; Pascal R Verdonck; Simon A McG Thom; Dean C Barratt; X Yun Xu
Operator dependence of 3-D ultrasound-based computational fluid dynamics for the carotid bifurcation.
IEEE transactions on medical imaging 2005;24(4):451-6.
2005: Lindsey Crowe; Ben Ariff; Jennifer Keegan; Raad H Mohiaddin; Guang-Zhong Yang; Alun HUGHES; Simon A McG Thom; David N Firmin
Comparison between three-dimensional volume-selective turbo spin-echo imaging and two-dimensional ultrasound for assessing carotid artery structure and function.
Journal of magnetic resonance imaging : JMRI 2005;21(3):282-9.
2005: Sumangali Wijetunge; Alun HUGHES
Mechanism of contraction of rat isolated tail arteries by hyposmotic solutions.
Journal of vascular research 2005;42(2):93-100.
2005: Ruwan C Wimalasundera; Simon A McG Thom; Lesley Regan; Alun HUGHES
Effects of vasoactive agents on intracellular calcium and force in myometrial and subcutaneous resistance arteries isolated from preeclamptic, pregnant, and nonpregnant woman.
American journal of obstetrics and gynecology 2005;192(2):625-32.
2004: Alun HUGHES
How do thiazide and thiazide-like diuretics lower blood pressure?
Journal of the renin-angiotensin-aldosterone system : JRAAS 2004;5(4):155-60.
2004: Fadi P Glor; Ben Ariff; Alun HUGHES; Lindsey Crowe; Pascal R Verdonck; Dean C Barratt; Simon A McG Thom; David N Firmin; X Yun Xu
Image-based carotid flow reconstruction: a comparison between MRI and ultrasound.
Physiological measurement 2004;25(6):1495-509.
2004: Fadi P Glor; Ben Ariff; Alun HUGHES; Pascal R Verdonck; Dean C Barratt; Alex Augst; Simon A McG Thom; X Yun Xu
Influence of head position on carotid hemodynamics in young adults.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1670-81.
2004: Dean C Barratt; Ben Ariff; Keith N Humphries; Simon A McG Thom; Alun HUGHES
Reconstruction and quantification of the carotid artery bifurcation from 3-D ultrasound images.
IEEE transactions on medical imaging 2004;23(5):567-83.
2004: Fadi P Glor; Ben Ariff; Alun HUGHES; Lindsey Crowe; Pascal R Verdonck; Dean C Barratt; Simon A McG Thom; D N Firmin; X Yun Xu
The integration of medical imaging and computational fluid dynamics for measuring wall shear stress in carotid arteries.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2004;2():1415-8.
2004: J Leung; A Wright; N J W Cheshire; Simon A McG Thom; Alun HUGHES; X Yun Xu
Flow patterns and wall shear stresses in patient-specific models of the abdominal aortic aneurysm.
Studies in health technology and informatics 2004;103():235-42.
2003: Joanne S Lymn; Karen L Gallagher; Gerard F Clunn; Sofi E Fexby; Mahendra K Patel; Alun HUGHES
PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive phosphatidylinositol 3-kinase.
FEBS letters 2003;555(3):591-6.
2003: Fadi P Glor; Ben Ariff; Lindsey Crowe; Alun HUGHES; P L Cheong; Simon A McG Thom; Pascal R Verdonck; David N Firmin; Dean C Barratt; X Yun Xu
Carotid geometry reconstruction: a comparison between MRI and ultrasound.
Medical physics 2003;30(12):3251-61.
2003: Jamil Mayet; Alun HUGHES
Cardiac and vascular pathophysiology in hypertension.
Heart (British Cardiac Society) 2003;89(9):1104-9.
2003: Colin D Bicknell; Mark G Cowling; Martin W Clark; Konstantinos T Delis; Michael P Jenkins; Alun HUGHES; Simon A McG Thom; J H N Wolfe; N J W Cheshire
Carotid angioplasty in a pulsatile flow model: factors affecting embolic potential.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2003;26(1):22-31.
2003: Peter Pickkers; Frans G M Russel; Theo Thien; Alun HUGHES; Paul Smits
Only weak vasorelaxant properties of loop diuretics in isolated resistance arteries from man, rat and guinea pig.
European journal of pharmacology 2003;466(3):281-7.
2003: Alex Augst; Dean C Barratt; Alun HUGHES; Fadi P Glor; Simon A McG Thom; X Yun Xu
Accuracy and reproducibility of CFD predicted wall shear stress using 3D ultrasound images.
Journal of biomechanical engineering 2003;125(2):218-22.
2003: R Wimalasundera; S Fexby; L Regan; Simon A McG Thom; Alun HUGHES
Effect of tumour necrosis factor-alpha and interleukin 1beta on endothelium-dependent relaxation in rat mesenteric resistance arteries in vitro.
British journal of pharmacology 2003;138(7):1285-94.
2003: Quan Long; Ben Ariff; SZ Zhao; Simon A McG Thom; Alun HUGHES; X Yun Xu
Reproducibility study of 3D geometrical reconstruction of the human carotid bifurcation from magnetic resonance images.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;49(4):665-74.
2003: Fadi P Glor; Quan Long; Alun HUGHES; Alex Augst; Ben Ariff; Simon A McG Thom; Pascal R Verdonck; X Yun Xu
Reproducibility study of magnetic resonance image-based computational fluid dynamics prediction of carotid bifurcation flow.
Annals of biomedical engineering 2003;31(2):142-51.
2003: Alex Augst; Dean C Barratt; Alun HUGHES; Simon A McG Thom; X Yun Xu
Various issues relating to computational fluid dynamics simulations of carotid bifurcation flow based on models reconstructed from three-dimensional ultrasound images.
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 2003;217(5):393-403.
2002: Andrew Zambanini; Simon A McG Thom; Alun HUGHES; Kim H Parker
Central aortic pressure influences pulse wave velocity.
Hypertension 2002;40(6):e10-1; author reply e10-1.
2002: Joanne S Lymn; Mahendra K Patel; Gerard F Clunn; Sarafina J Rao; Karen L Gallagher; Alun HUGHES
Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level.
Journal of cell science 2002;115(Pt 22):4353-60.
2002: Ruwan Wimalasundera; Nick Larbalestier; J H Smith; Annemiek de Ruiter; Simon A McG Thom; Alun HUGHES; N Poulter; Lesley Regan; Graham P Taylor
Pre-eclampsia, antiretroviral therapy, and immune reconstitution.
Lancet 2002;360(9340):1152-4.
2002: SZ Zhao; Ben Ariff; Quan Long; Alun HUGHES; Simon A McG Thom; Alice V Stanton; X Yun Xu
Inter-individual variations in wall shear stress and mechanical stress distributions at the carotid artery bifurcation of healthy humans.
Journal of biomechanics 2002;35(10):1367-77.
2002: Neil Chapman; G Dell'omo; M S Sartini; Nicholas Witt; Alun HUGHES; Simon Thom; Roberto Pedrinelli
Peripheral vascular disease is associated with abnormal arteriolar diameter relationships at bifurcations in the human retina.
Clinical science (London, England : 1979) 2002;103(2):111-6.
2002: M Elena Martinez-Perez; Alun HUGHES; Alice V Stanton; Simon A McG Thom; Neil Chapman; Anil A Bharath; Kim H Parker
Retinal vascular tree morphology: a semi-automatic quantification.
IEEE transactions on bio-medical engineering 2002;49(8):912-7.
2002: Ben Ariff; Alice Stanton; Dean C Barratt; Alex Augst; Fadi P Glor; Neil Poulter; Peter S Sever; Yun Xu; Alun HUGHES; Simon A McG Thom
Comparison of the effects of antihypertensive treatment with angiotensin II blockade and beta-blockade on carotid wall structure and haemodynamics: protocol and baseline demographics.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2002;3(2):116-22.
2002: Ruwan Wimalasundera; Simon A McG Thom; Lesley Regan; Alun HUGHES
Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects.
Clinical science (London, England : 1979) 2002;102(6):661-6.
2002: Jamil Mayet; Alice V Stanton; Neil Chapman; Rodney A Foale; Alun HUGHES; Simon A McG Thom
Is carotid artery intima-media thickening a reliable marker of early atherosclerosis?
Journal of cardiovascular risk 2002;9(2):77-81.
2002: Alice V Stanton; Jamil Mayet; Neil Chapman; Rodney A Foale; Alun HUGHES; Simon A McG Thom
Ethnic differences in carotid and left ventricular hypertrophy.
Journal of hypertension 2002;20(3):539-43.
2002: Mirian J Starmans-Kool; Alice V Stanton; Shunzhi Zhao; X Yun Xu; Simon A McG Thom; Alun HUGHES
Measurement of hemodynamics in human carotid artery using ultrasound and computational fluid dynamics.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(3):957-61.
2002: Sumangali Wijetunge; A C Dolphin; Alun HUGHES
Tyrosine kinases act directly on the alpha1 subunit to modulate Ca(v)2.2 calcium channels.
Biochemical and biophysical research communications 2002;290(4):1246-9.
2002: E King; X Yun Xu; Alun HUGHES; Quan Long; Simon A McG Thom; Kim H Parker
Quantification of the non-planarity of the human carotid bifurcation.
Biorheology 2002;39(3-4):419-24.
2002: Mahendra K Patel; Barbara Mulloy; Karen L Gallagher; Leisha O'Brien; Alun HUGHES
The antimitogenic action of the sulphated polysaccharide fucoidan differs from heparin in human vascular smooth muscle cells.
Thrombosis and haemostasis 2002;87(1):149-54.
2001: Alice V Stanton; JN Chapman; Jamil Mayet; Peter S Sever; Neil R Poulter; Alun HUGHES; Simon A McG Thom
Effects of blood pressure lowering with amlodipine or lisinopril on vascular structure of the common carotid artery.
Clinical science (London, England : 1979) 2001;101(5):455-64.
2001: Dean C Barratt; A H Davies; Alun HUGHES; Simon A McG Thom; Keith N Humphries
Accuracy of an electromagnetic three-dimensional ultrasound system for carotid artery imaging.
Ultrasound in medicine & biology 2001;27(10):1421-5.
2001: Robinder S Garcha; Peter S Sever; Alun HUGHES
Mechanism of action of angiotensin II in human isolated subcutaneous resistance arteries.
British journal of pharmacology 2001;134(1):188-96.
2001: Alice Stanton; D Fitzgerald; Alun HUGHES; Jamil Mayet; Eoin O'Brien; N R Poulter; Peter S Sever; D Shields; Simon Thom
An intensive phenotyping study to enable the future examination of genetic influences on hypertension-associated cardiovascular disease.
Journal of human hypertension 2001;15 Suppl 1():S13-8.
2001: S Unlu; Gerard F Clunn; M Schachter; CD Demoliou-Mason; Alun HUGHES
Action of an HMG CoA reductase inhibitor, lovastatin, on apoptosis of untransformed and ts-SV40 transformed human smooth muscle cells derived from saphenous vein.
Journal of cardiovascular pharmacology 2001;38(2):161-73.
2001: Dean C Barratt; A H Davies; Alun HUGHES; Simon A McG Thom; Keith N Humphries
Optimisation and evaluation of an electromagnetic tracking device for high-accuracy three-dimensional ultrasound imaging of the carotid arteries.
Ultrasound in medicine & biology 2001;27(7):957-68.
2001: Alun HUGHES; S Thom
Wearing your heart in your sleeve?
European heart journal 2001;22(13):1071-3.
2001: P S Sever; Alun HUGHES
Angiotensin receptor antagonists and vaso-vagal attacks due to sensitisation of the Bezold-Jarisch reflex?
Journal of human hypertension 2001;15(6):437-8.
2001: Peter Pickkers; Alun HUGHES; Frans G M Russel; Theo Thien; Paul Smits
In vivo evidence for K(Ca) channel opening properties of acetazolamide in the human vasculature.
British journal of pharmacology 2001;132(2):443-50.
2001: Neil Chapman; Nicholas Witt; X Gao; Anil A Bharath; Alice V Stanton; Simon A McG Thom; Alun HUGHES
Computer algorithms for the automated measurement of retinal arteriolar diameters.
The British journal of ophthalmology 2001;85(1):74-9.
2000: Gerard F Clunn; Alun HUGHES; M Schachter
Endotoxin-lipoprotein hypothesis.
Lancet 2000;356(9247):2097-8.
2000: Neil Chapman; G Haimes; Alice V Stanton; Simon A McG Thom; Alun HUGHES
Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects.
Clinical science (London, England : 1979) 2000;99(6):483-8.
2000: Jamila Ibrahim; Alun HUGHES; Peter S Sever
Action of angiotensin II on DNA synthesis by human saphenous vein in organ culture.
Hypertension 2000;36(5):917-21.
2000: X W Gao; Anil A Bharath; Alice Stanton; Alun HUGHES; Neil Chapman; Simon Thom
Quantification and characterisation of arteries in retinal images.
Computer methods and programs in biomedicine 2000;63(2):133-46.
2000: SZ Zhao; X Yun Xu; Alun HUGHES; Simon A McG Thom; Alice V Stanton; Ben Ariff; Quan Long
Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation.
Journal of biomechanics 2000;33(8):975-84.
2000: Alun HUGHES
AT(1)-signalling in vascular smooth muscle.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2000;1(2):125-30.
2000: Harris Pratsinis; CD Demoliou-Mason; Alun HUGHES; Dimitris Kletsas
A novel in vitro model of conditionally immortalized human vascular smooth muscle cells. A tool for aging studies.
Annals of the New York Academy of Sciences 2000;908():321-3.
2000: Peter B Hill; Kim A Dora; Alun HUGHES; Christopher J Garland
The involvement of intracellular Ca(2+) in 5-HT(1B/1D) receptor-mediated contraction of the rabbit isolated renal artery.
British journal of pharmacology 2000;130(4):835-42.
2000: Jung-Kuang Hsieh; D Kletsas; Gerard F Clunn; Alun HUGHES; M Schachter; CD Demoliou-Mason
p53, p21(WAF1/CIP1), and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(4):973-81.
2000: Sumangali Wijetunge; Joanne S Lymn; Alun HUGHES
Effects of protein tyrosine kinase inhibitors on voltage-operated calcium channel currents in vascular smooth muscle cells and pp60(c-src) kinase activity.
British journal of pharmacology 2000;129(7):1347-54.
2000: Quan Long; X Yun Xu; Ben Ariff; Simon A McG Thom; Alun HUGHES; Alice V Stanton
Reconstruction of blood flow patterns in a human carotid bifurcation: a combined CFD and MRI study.
Journal of magnetic resonance imaging : JMRI 2000;11(3):299-311.
2000: Jung-Kuang Hsieh; D Kletsas; Gerard F Clunn; Alun HUGHES; M Schachter; CD Demoliou-Mason
p53, p21(WAF1/CIP1), and MDM2 involvement in proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(3):636-44.
2000: S Unlu; CD Mason; M Schachter; Alun HUGHES
Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro.
Journal of cardiovascular pharmacology 2000;35(2):341-4.
1999: J E Coombes; Alun HUGHES; Simon A McG Thom
Intravascular pressure-evoked changes in intracellular calcium [Ca2+]i and tone in rat mesenteric and rabbit cerebral arteries in vitro.
Journal of human hypertension 1999;13(12):855-8.
1999: Gerard F Clunn; Sumangali Wijetunge; Alun HUGHES
Effect of hypercholesterolaemia on voltage-operated calcium channel currents in rabbit arterial smooth muscle cells.
Journal of human hypertension 1999;13(12):849-53.
1999: Joanne S Lymn; S J Rao; Gerard F Clunn; Karen L Gallagher; C O'Neil; N T Thompson; Alun HUGHES
Phosphatidylinositol 3-kinase and focal adhesion kinase are early signals in the growth factor-like responses to thrombospondin-1 seen in human vascular smooth muscle.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2133-40.
1999: P Pickkers; M van Beek; Alun HUGHES; F G Russel; Theo Thien; Paul Smits
Presence and mechanism of direct vascular effects of amiloride in humans.
Journal of cardiovascular pharmacology 1999;34(3):388-93.
1999: Robinder S Garcha; Peter S Sever; Alun HUGHES
Action of AT1 receptor antagonists on angiotensin II-induced tone in human isolated subcutaneous resistance arteries.
British journal of pharmacology 1999;127(8):1876-82.
1999: Jamila Ibrahim; M Schachter; Alun HUGHES; Peter S Sever
Low dose indapamide plus perindopril combination effects on cardiovascular structure and function in genetic hypertension.
Clinical and experimental pharmacology & physiology 1999;26(8):622-7.
1999: SZ Zhao; X Yun Xu; MW Collins; Alice V Stanton; Alun HUGHES; Simon A McG Thom
Flow in carotid bifurcations: effect of the superior thyroid artery.
Medical engineering & physics 1999;21(4):207-14.
1999: M K Patel; JS Refson; M Schachter; Alun HUGHES
Characterization of [3H]-heparin binding in human vascular smooth muscle cells and its relationship to the inhibition of DNA synthesis.
British journal of pharmacology 1999;127(2):361-8.
1999: Peter Pickkers; R S Garcha; M Schachter; Paul Smits; Alun HUGHES
Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide.
Hypertension 1999;33(4):1043-8.
1998: Alun HUGHES; Sumangali Wijetunge
Role of tyrosine phosphorylation in excitation-contraction coupling in vascular smooth muscle.
Acta physiologica Scandinavica 1998;164(4):457-69.
1998: Peter Pickkers; Alun HUGHES; Frans G M Russel; Theo Thien; Paul Smits
Thiazide-induced vasodilation in humans is mediated by potassium channel activation.
Hypertension 1998;32(6):1071-6.
1998: S Unlu; CD Mason; Alun HUGHES
Platelet-derived growth factor-BB induces apoptosis in cultured vascular smooth muscle cells derived from human saphenous vein.
Biochemical Society transactions 1998;26(4):S325.
1998: S Unlu; CD Mason; Alun HUGHES
Role of isoprenylation in the inhibitory action of lovastatin on proliferation of SV40 immortalized human saphenous vein smooth muscle cells.
Biochemical Society transactions 1998;26(4):S324.
1998: S Unlu; CD Mason; M Schachter; Alun HUGHES
Interactions between HMG-CoA reductase inhibition and UVB irradiation on proliferation and apoptosis in SM1 smooth muscle cells.
Biochemical Society transactions 1998;26(4):S322.
1998: L Xie; Gerard F Clunn; Joanne S Lymn; Alun HUGHES
Role of intracellular calcium ([Ca2+]i) and tyrosine phosphorylation in adhesion of cultured vascular smooth muscle cells to fibrinogen.
Cardiovascular research 1998;39(2):475-84.
1998: JS Refson; M Schachter; M K Patel; Alun HUGHES; E Munro; P Chan; J H Wolfe; Peter S Sever
Vein graft stenosis and the heparin responsiveness of human vascular smooth muscle cells.
Circulation 1998;97(25):2506-10.
1998: EA Hodson; Christopher C Ashley; Alun HUGHES; JS Lymn
Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator.
Biochimica et biophysica acta 1998;1403(1):97-101.
1998: Alun HUGHES
Molecular and cellular mechanisms of action of angiotensin II (AT1) receptors in vascular smooth muscle.
Journal of human hypertension 1998;12(5):275-81.
1998: EA Hodson; Christopher C Ashley; Alun HUGHES; JS Lymn
Regulation of phospholipase C delta 1 activity by GTP-binding proteins: rhoA as an inhibitory modulator.
Biochemical Society transactions 1998;26(2):S128.
1998: Sumangali Wijetunge; Joanne S Lymn; Alun HUGHES
Effect of inhibition of tyrosine phosphatases on voltage-operated calcium channel currents in rabbit isolated ear artery cells.
British journal of pharmacology 1998;124(2):307-16.
1997: Neil Chapman; A Mohamudally; A Cerutti; Alice Stanton; Avan Aihie Sayer; Cyrus Cooper; D Barker; A Rauf; J Evans; Richard Wormald; Peter S Sever; Alun HUGHES; Simon Thom
Retinal vascular network architecture in low-birth-weight men.
Journal of hypertension 1997;15(12 Pt 1):1449-53.
1997: Gerard F Clunn; JS Refson; Joanne S Lymn; Alun HUGHES
Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2622-9.
1997: Mahendra K Patel; Joanne S Lymn; Gerard F Clunn; Alun HUGHES
Thrombospondin-1 is a potent mitogen and chemoattractant for human vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):2107-14.
1997: Peter Pickkers; TP Dormans; Frans G M Russel; Alun HUGHES; Theo Thien; N Schaper; Paul Smits
Direct vascular effects of furosemide in humans.
Circulation 1997;96(6):1847-52.
1997: N Sawhney; M K Patel; M Schachter; Alun HUGHES
Inhibition of proliferation by heparin and expression of p53 in cultured human vascular smooth muscle cells.
Journal of human hypertension 1997;11(9):611-4.
1997: R S Garcha; Alun HUGHES
Action of ryanodine on neurogenic responses in rat isolated mesenteric small arteries.
British journal of pharmacology 1997;122(1):142-8.
1997: Gerard F Clunn; Joanne S Lymn; M Schachter; Alun HUGHES
Differential effects of lovastatin on mitogen induced calcium influx in human cultured vascular smooth muscle cells.
British journal of pharmacology 1997;121(8):1789-95.
1996: Sumangali Wijetunge; Alun HUGHES
Activation of endogenous c-Src or a related tyrosine kinase by intracellular (pY)EEI peptide increases voltage-operated calcium channel currents in rabbit ear artery cells.
FEBS letters 1996;399(1-2):63-6.
1996: Alun HUGHES; Gerard F Clunn; J Refson; C Demoliou-Mason
Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle.
General pharmacology 1996;27(7):1079-89.
1996: M K Patel; Gerard F Clunn; J S Lymn; Alun HUGHES
Thrombospondin-1 induces DNA synthesis and migration in human vascular smooth muscle cells.
Biochemical Society transactions 1996;24(3):446S.
1996: J Ibrahim; Alun HUGHES; M Schachter; Peter S Sever
Depletion of resistance vessel polyamines attenuates angiotensin II induced blood pressure rise in rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1996;18(6):811-30.
1996: Peter Pickkers; M Schachter; Alun HUGHES; M D Feher; Peter S Sever
Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels?
Diabetologia 1996;39(7):861-4.
1996: L A King; Alice V Stanton; Peter S Sever; Simon A McG Thom; Alun HUGHES
Arteriolar length-diameter (L:D) ratio: a geometric parameter of the retinal vasculature diagnostic of hypertension.
Journal of human hypertension 1996;10(6):417-8.
1996: Alun HUGHES
The role of isoprenoids in vascular smooth muscle: potential benefits of statins unrelated to cholesterol lowering.
Journal of human hypertension 1996;10(6):387-90.
1996: J Ibrahim; Alun HUGHES; M Schachter; Peter S Sever
Enhanced tissue polyamine content in the spontaneously hypertensive rat.
Clinical and experimental pharmacology & physiology 1996;23(5):410-4.
1996: M K Patel; L J Betteridge; Alun HUGHES; Gerard F Clunn; M Schachter; Rory J Shaw; Peter S Sever
Effect of angiotension II on the expression of the early growth response gene c-fos and DNA synthesis in human vascular smooth muscle cells.
Journal of hypertension 1996;14(3):341-7.
1996: Alun HUGHES; N A Parkinson; Sumangali Wijetunge
alpha2-Adrenoceptor activation increases calcium channel currents in single vascular smooth muscle cells isolated from human omental resistance arteries.
Journal of vascular research 1996;33(1):25-31.
1995: Sumangali Wijetunge; Alun HUGHES
pp60c-src increases voltage-operated calcium channel currents in vascular smooth muscle cells.
Biochemical and biophysical research communications 1995;217(3):1039-44.
1995: Peter Pickkers; Frans G M Russel; Alun HUGHES; Theo Thien; Paul Smits
Hydrochlorothiazide exerts no direct vasoactivity in the human forearm.
Journal of hypertension 1995;13(12 Pt 2):1833-6.
1995: Alice V Stanton; B Wasan; A Cerutti; S Ford; R Marsh; P P Sever; Simon A McG Thom; Alun HUGHES
Vascular network changes in the retina with age and hypertension.
Journal of hypertension 1995;13(12 Pt 2):1724-8.
1995: Gerard F Clunn; J S Refson; M Schachter; Alun HUGHES
Different effects of platelet derived growth factor isoforms on DNA synthesis and migration in human vascular smooth muscle cells.
Biochemical Society transactions 1995;23(4):608S.
1995: Alun HUGHES
Calcium channels in vascular smooth muscle cells.
Journal of vascular research 1995;32(6):353-70.
1995: Alun HUGHES; Thomas B Bolton
Action of angiotensin II, 5-hydroxytryptamine and adenosine triphosphate on ionic currents in single ear artery cells of the rabbit.
British journal of pharmacology 1995;116(3):2148-54.
1995: M Schachter; L J Betteridge; Alun HUGHES; M K Patel
Angiotensin II receptors are exclusively of the AT1 subtype in cultured human vascular smooth muscle cells.
Biochemical Society transactions 1995;23(3):458S.
1995: N A Parkinson; Alun HUGHES
The mechanism of action of alpha 2-adrenoceptors in human isolated subcutaneous resistance arteries.
British journal of pharmacology 1995;115(8):1463-8.
1995: Peter Pickkers; M Schachter; Peter S Sever; Alun HUGHES
Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?
Journal of human hypertension 1995;9(8):691-3.
1995: Jamil Mayet; Manjit Shahi; Alun HUGHES; Alice V Stanton; N R Poulter; Peter S Sever; Rodney A Foale; Simon A McG Thom
Left ventricular structure and function in previously untreated hypertensive patients: the importance of blood pressure, the nocturnal blood pressure dip and heart rate.
Journal of cardiovascular risk 1995;2(3):255-61.
1995: Sumangali Wijetunge; Alun HUGHES
Effect of platelet-derived growth factor on voltage-operated calcium channels in rabbit isolated ear artery cells.
British journal of pharmacology 1995;115(3):534-8.
1995: Alun HUGHES; M Schachter
AIF4- inhibits influx of Ca2+ into vascular smooth muscle cells.
Biochemical Society transactions 1995;23(2):171S.
1995: Gerard F Clunn; M Schachter; Alun HUGHES
Contrasting mechanisms of intracellular calcium ([Ca2+]i) elevation by angiotensin II (AII) and platelet derived growth factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs).
Biochemical Society transactions 1995;23(2):170S.
1995: R S Garcha; Alun HUGHES
Inhibition of norepinephrine and caffeine-induced activation by ryanodine and thapsigargin in rat mesenteric arteries.
Journal of cardiovascular pharmacology 1995;25(5):840-6.
1995: Alun HUGHES; M Patel; Sumangali Wijetunge; Gerard F Clunn; M Schachter
Comparison of effects of platelet-derived growth factor isoforms on signaling and DNA synthesis of human cultured saphenous vein cells.
Journal of cardiovascular pharmacology 1995;25(3):481-5.
1995: C Toma; P E Jensen; Dolores Prieto; Alun HUGHES; Michael J Mulvany; Christian Aalkjaer
Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric resistance arteries.
British journal of pharmacology 1995;114(6):1266-72.
1995: Peter Pickkers; Alun HUGHES
Relaxation and decrease in [Ca2+]i by hydrochlorothiazide in guinea-pig isolated mesenteric arteries.
British journal of pharmacology 1995;114(3):703-7.
1995: J Ibrahim; M Schachter; Alun HUGHES; Peter S Sever
Role of polyamines in hypertension induced by angiotensin II.
Cardiovascular research 1995;29(1):50-6.
1995: Alun HUGHES; A M Sinclair; George Geroulakos; Jamil Mayet; J Mackay; Manjit Shahi; Simon Thom; Andrew Nicolaides; Peter S Sever
Structural changes in the cardiovascular system of untreated essential hypertensives.
Blood pressure 1995;4(1):42-7.
1995: Alun HUGHES
Increase in tone and intracellular Ca2+ in rabbit isolated ear artery by platelet-derived growth factor.
British journal of pharmacology 1995;114(1):138-42.
1994: E Munro; M Patel; P Chan; L Betteridge; Gerard F Clunn; K Gallagher; Alun HUGHES; M Schachter; J Wolfe; Peter S Sever
Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis.
European journal of clinical investigation 1994;24(11):766-72.
1994: R S Garcha; Alun HUGHES
Action of heparin and ruthenium red on responses of reversibly-permeabilised rat mesenteric arteries.
European journal of pharmacology 1994;268(3):319-25.
1994: Alun HUGHES; Sumangali Wijetunge; N A Parkinson
Isolation of single vascular smooth muscle cells from human omental resistance arteries.
Journal of human hypertension 1994;8(8):615-8.
1994: Alun HUGHES; Gerard F Clunn; M Schachter
A comparison of calcium channel currents in vascular smooth muscle cells from Watanabe hereditary hypercholesterolaemic and New Zealand white rabbits.
Biochemical Society transactions 1994;22(3):361S.
1994: Alun HUGHES; Gerard F Clunn; M Schachter
Low density lipoprotein and calcium homeostasis in human vascular smooth muscle cells.
Biochemical Society transactions 1994;22(2):145S.
1994: Alun HUGHES; M Schachter
Hypertension and blood vessels.
British medical bulletin 1994;50(2):356-70.
1994: Alun HUGHES; M Schachter
Multiple pathways for entry of calcium and other divalent cations in a vascular smooth muscle cell line (A7r5).
Cell calcium 1994;15(4):317-30.
1993: A M Sinclair; Alun HUGHES; Peter S Sever
Effect of nifedipine and glyceryl trinitrate on retinal blood flow in normal subjects.
Journal of human hypertension 1993;7(4):399-401.
1993: Alun HUGHES; A M Sinclair; George Geroulakos; Jamil Mayet; J Mackay; Manjit Shahi; Simon Thom; Andrew Nicolaides; Peter S Sever
Structural changes in the heart and carotid arteries associated with hypertension in humans.
Journal of human hypertension 1993;7(4):395-7.
1993: P E Jensen; Alun HUGHES; H C Boonen; Christian Aalkjaer
Force, membrane potential, and [Ca2+]i during activation of rat mesenteric small arteries with norepinephrine, potassium, aluminum fluoride, and phorbol ester. Effects of changes in pHi.
Circulation research 1993;73(2):314-24.
1993: R S Garcha; Peter S Sever; Alun HUGHES
The action of amlodipine on human subcutaneous resistance arteries studied in vitro.
The Journal of pharmacology and experimental therapeutics 1993;265(2):860-5.
1993: Alun HUGHES; Sumangali Wijetunge
The action of amlodipine on voltage-operated calcium channels in vascular smooth muscle.
British journal of pharmacology 1993;109(1):120-5.
1993: W Sunman; G Martin; W M Hair; Peter S Sever; Alun HUGHES
Effect of calcium antagonists on endothelin-induced contraction of isolated human resistance arteries: differences related to site of origin.
Journal of human hypertension 1993;7(2):189-91.
1993: W Sunman; Alun HUGHES; Peter S Sever
Free-radical scavengers, thiol-containing reagents and endothelium-dependent relaxation in isolated rat and human resistance arteries.
Clinical science (London, England : 1979) 1993;84(3):287-95.
1993: Steffen Hering; Alun HUGHES; Eugen N Timin; Thomas B Bolton
Modulation of calcium channels in arterial smooth muscle cells by dihydropyridine enantiomers.
The Journal of general physiology 1993;101(3):393-410.
1992: Sumangali Wijetunge; C Aalkjaer; M Schachter; Alun HUGHES
Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells.
Biochemical and biophysical research communications 1992;189(3):1620-3.
1992: N A Parkinson; S M Thom; Alun HUGHES; Peter S Sever; M J Mulvany; H Nielsen
Neurally evoked responses of human isolated resistance arteries are mediated by both alpha 1- and alpha 2-adrenoceptors.
British journal of pharmacology 1992;106(3):568-73.
1992: W Sunman; Alun HUGHES; Peter S Sever
Anaphylactoid response to intravenous acetylcysteine.
Lancet 1992;339(8803):1231-2.
1992: Simon Thom; Alun HUGHES; M Schachter; Peter S Sever
Celiprolol.
Lancet 1992;339(8787):247.
1991: R Garcha; M Schachter; Alun HUGHES; S M Thom; Peter S Sever
Amlodipine inhibition of alpha-agonist induced contraction in human resistance vessels.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1991;9(6):S368-9.
1991: Christian Aalkjaer; Alun HUGHES
Chloride and bicarbonate transport in rat resistance arteries.
The Journal of physiology 1991;436():57-73.
1991: S J Gatley; Eugene R DeSombre; RONNIE MEASE; R E Seevers; Alun HUGHES; J Li; M L Pan
Synthesis, purification and stability of no carrier added radioiodinated 1,1-bis(4-hydroxyphenyl)-2-iodo-2-phenylethylene (IBHPE), a prototype triphenylethylene estrogen-receptor binding radiopharmaceutical.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(7):769-75.
1990: Alun HUGHES; Steffen Hering; Thomas B Bolton
Evidence that agonist and antagonist enantiomers of the dihydropyridine PN 202-791 act at different sites on the voltage-dependent calcium channel of vascular muscle.
British journal of pharmacology 1990;101(1):3-5.
1990: L M Videbaek; Christian Aalkjaer; Alun HUGHES; Michael J Mulvany
Effect of pinacidil on ion permeability in resting and contracted resistance vessels.
The American journal of physiology 1990;259(1 Pt 2):H14-22.
1990: Alun HUGHES; Steffen Hering; Thomas B Bolton
The action of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells.
Pflügers Archiv : European journal of physiology 1990;416(4):462-6.
1990: Eugene R DeSombre; Alun HUGHES; S J Gatley; Jeffrey L Schwartz; P V Harper
Receptor-directed radiotherapy: a new approach to therapy of steroid receptor positive cancers.
Progress in clinical and biological research 1990;322():295-309.
1990: Michael J Mulvany; L M Videbaek; Alun HUGHES; Christian Aalkjaer
Mechanism of the vasodilator action of pinacidil.
Blood vessels 1990;27(2-5):314-8.
1989: Alun HUGHES; H Nielsen; Peter S Sever
The effect of atrial natriuretic peptide on human isolated resistance arteries.
British journal of pharmacology 1989;97(4):1027-30.
1989: H Nielsen; S M Thom; Alun HUGHES; G N Martin; M J Mulvany; Peter S Sever
Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels.
British journal of pharmacology 1989;97(3):829-34.
1989: Alun HUGHES; Peter S Sever
The action of dopamine and vascular dopamine (DA1) receptor agonists on human isolated subcutaneous and omental small arteries.
British journal of pharmacology 1989;97(3):950-6.
1989: Alun HUGHES; Peter S Sever
Specific binding of 125I SCH 23982, a selective dopamine (D1) receptor ligand to plasma membranes derived from human kidney cortex.
Biochemical pharmacology 1989;38(5):781-5.
1989: Alun HUGHES; Peter S Sever
Action of fenoldopam, a selective dopamine (DA1) receptor agonist, on isolated human arteries.
Blood vessels 1989;26(2):119-27.
1989: Alun HUGHES; Simon A McG Thom; N Woodall; M Schachter; W M Hair; G N Martin; Peter S Sever
Human vascular responses to endothelin-1: observations in vivo and in vitro.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S225-8.
1988: Simon Cross; Alun HUGHES; Geraint T Williams; E D Williams
Endocrine cell hyperplasia and appendiceal carcinoids.
The Journal of pathology 1988;156(4):325-9.
1988: Alun HUGHES; Simon A McG Thom; G N Martin; H Nielsen; W M Hair; M Schachter; Peter S Sever
Size and site-dependent heterogeneity of human vascular responses in vitro.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(4):S173-5.
1988: Alun HUGHES; P Inkpen; Peter S Sever
Action of dopamine on isolated human saphenous veins.
Journal of cardiovascular pharmacology 1988;11(3):373-7.
1988: Alun HUGHES; Simon Thom; P Goldberg; G Martin; Peter S Sever
Direct effect of alpha-human atrial natriuretic peptide on human vasculature in vivo and in vitro.
Clinical science (London, England : 1979) 1988;74(2):207-11.
1987: Simon Thom; Alun HUGHES; G Martin; Peter S Sever
Endothelium-dependent relaxation in isolated human arteries and veins.
Clinical science (London, England : 1979) 1987;73(5):547-52.
1987: Alun HUGHES; G Martin; P Goldberg; Simon Thom; Peter S Sever
No evidence for a direct vasodilatory effect of celiprolol on human vasculature in vivo or in vitro.
Journal of cardiovascular pharmacology 1987;10(5):589-92.
1987: S M Thom; Alun HUGHES; P Goldberg; G Martin; M Schachter; Peter S Sever
The actions of calcitonin gene related peptide and vasoactive intestinal peptide as vasodilators in man in vivo and in vitro.
British journal of clinical pharmacology 1987;24(2):139-44.
1987: Alun HUGHES; Simon A McG Thom; N M Woodall; D Redman; Peter S Sever
Dopamine produces forearm vasodilatation following alpha-adrenoceptor blockade by an action on vascular dopamine (DA1) receptors in man.
Journal of hypertension 1987;5(3):337-40.
1986: Alun HUGHES; Simon Thom; G Martin; D Redman; S Hasan; Peter S Sever
The action of a dopamine (DA1) receptor agonist, fenoldopam in human vasculature in vivo and in vitro.
British journal of clinical pharmacology 1986;22(5):535-40.
1985: D Redman; Simon A McG Thom; Alun HUGHES; S Hasan; Peter S Sever
Human vasodilator responses to a dopamine agonist: possible mechanisms.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1985;3(3):S177-8.
1985: Simon A McG Thom; Alun HUGHES; G N Martin; Peter S Sever
The release of the endothelium derived relaxing factor from isolated human arteries.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1985;3(3):S97-9.
1981: S P Canfield; Alun HUGHES; C A Price; J E Spencer
The action of beta-adrenoceptor agonists on acid secretion by the rat isolated stomach.
The Journal of physiology 1981;316():23-31.