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Richard Neubig

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Chemicals & Drugs

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TOP 3
William K Lim; Kimon C Kanelakis; Richard Neubig
Regulation of G protein signaling by the 70kDa heat shock protein.
Andrew J Storaska; Richard Neubig
NMR methods for detection of small molecule binding to RGS4.
Hyeseon Cho; Ji-Liang Gao; Il-Young Hwang; Olena Kamenyeva; Philip M Murphy; Richard Neubig; Chung Park; Sunny Yung; John Kehrl
The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites.

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All Publications

2013: William K Lim; Kimon C Kanelakis; Richard Neubig
Regulation of G protein signaling by the 70kDa heat shock protein.
Cellular signalling 2013;25(2):389-96.
2013: Andrew J Storaska; Richard Neubig
NMR methods for detection of small molecule binding to RGS4.
Methods in enzymology 2013;522():133-52.
2012: Hyeseon Cho; Ji-Liang Gao; Il-Young Hwang; Olena Kamenyeva; Philip M Murphy; Richard Neubig; Chung Park; Sunny Yung; John Kehrl
The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites.
Molecular and cellular biology 2012;32(22):4561-71.
2012: Pengfei Li; Richard Neubig; Basilia Zingarelli; KT Borg; James A Cook; Perry V Halushka; Hongkuan Fan
Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Gα(i2) protein.
Inflammation 2012;35(5):1611-7.
2012: Renju T Jacob; Paul D Kirchhoff; Martha J Larsen; Scott D Larsen; David H Sherman; Richard Neubig
MScreen: an integrated compound management and high-throughput screening data storage and analysis system.
Journal of biomolecular screening 2012;17(8):1080-7.
2012: Benita Sjögren; Zie-Jian Xie; Kevin B Atkins; Lauren J Heath; Sergio Parra; Richard Neubig
Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels.
Molecular pharmacology 2012;82(3):500-9.
2012: Kuljeet Kaur; Raelene A Charbeneau; Rong Chen; Patrick Y Jay; Sergio Parra; Susan M Wade; Richard Neubig
Gαi2 signaling: friend or foe in cardiac injury and heart failure?
Naunyn-Schmiedeberg's archives of pharmacology 2012;385(5):443-53.
2012: Peisong Ma; Richard Neubig; Debra K Newman; Rachel Signarvic; Andrew J Sinnamon; Timothy J Stalker; Aleksandra Cierniewska; Marcin Cieslak; Hong Kong; Lawrence F Brass
A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.
Blood 2012;119(8):1935-45.
2012: Scott H Visovatti; Diane Bouis; Matthew C Hyman; Vallerie V McLaughlin; Richard Neubig; David J Pinsky
Increased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension.
PloS one 2012;7(7):e40829.
2011: Andrew M Fribley; Renju R Jacobs; Douglas A Burr; Peter Cai; Michael U Callaghan; Patricia G Cruz; Paul D Kirchhoff; Martha J Larsen; Scott D Larsen; Justin R Miller; Neha Narula; Richard Neubig; David Ron; Pamela J Schultz; David H Sherman; Hollis D Showalter; Giselle Tamayo; Randal J Kaufman
Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.
Journal of biomolecular screening 2011;16(8):825-35.
2011: Andreja Jovic; Jennifer J Linderman; Atsushi Miyawaki; Richard Neubig; Susan M Wade; Shuichi Takayama
Hi-Fi transmission of periodic signals amid cell-to-cell variability.
Molecular bioSystems 2011;7(7):2238-44.
2011: Rachael E Waterson; Jeffery N Talbot; Corbin G Thompson; Kuljeet Kaur; Nathaniel W Mabe; Richard Neubig; Boyd R Rorabaugh
Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart.
Cardiovascular research 2011;91(1):45-52.
2011: Levi L Blazer; Haoming Zhang; Emma M Casey; Stephen M Husbands; Richard Neubig
A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins.
Biochemistry 2011;50(15):3181-92.
2011: Richard Neubig
Major developments in our understanding of G protein-coupled receptors.
Advances in pharmacology (San Diego, Calif.) 2011;62():xv-xvi.
2011: Kuljeet Kaur; Jason M Kehrl; Raelene A Charbeneau; Richard Neubig
RGS-insensitive Gα subunits: probes of Gα subtype-selective signaling and physiological functions of RGS proteins.
Methods in molecular biology (Clifton, N.J.) 2011;756():75-98.
2010: Rachel S Signarvic; Aleksandra Cierniewska; Timothy J Stalker; Karen P Fong; Manash S Chatterjee; Paul R Hess; Peisong Ma; Scott L Diamond; Richard Neubig; Lawrence F Brass
RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury.
Blood 2010;116(26):6092-100.
2010: Benita Sjögren; Richard Neubig
Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.
Molecular pharmacology 2010;78(4):550-7.
2010: Richard Neubig
Mind your salts: when the inactive constituent isn't.
Molecular pharmacology 2010;78(4):558-9.
2010: Kiyohito Murai; Runxiang Qiu; Heying Zhang; Jun Wang; Chen Wu; Richard Neubig; Qiang Lu
Gα subunit coordinates with ephrin-B to balance self-renewal and differentiation in neural progenitor cells.
Stem cells (Dayton, Ohio) 2010;28(9):1581-9.
2010: Levi L Blazer; David Roman; Alfred Chung; Martha J Larsen; Benjamin M Greedy; Stephen M Husbands; Richard Neubig
Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.
Molecular pharmacology 2010;78(3):524-33.
2010: David Roman; Levi L Blazer; C Aaron Monroy; Richard Neubig
Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986.
Molecular pharmacology 2010;78(3):360-5.
2010: George Khelashvili; Kevin Dorff; Jufang Shan; Marta Camacho-Artacho; Lucy Skrabanek; Bas Vroling; Michel Bouvier; Lakshmi A Devi; Susan R George; Jonathan A Javitch; Martin J Lohse; Graeme Milligan; Richard Neubig; Krzysztof Palczewski; Marc Parmentier; Jean-Philippe Pin; Gert Vriend; Fabien Campagne; Marta Filizola
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.
Bioinformatics (Oxford, England) 2010;26(14):1804-5.
2010: Harvey J Motulsky; Richard Neubig
Analyzing binding data.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2010;Chapter 7():Unit 7.5.
2010: Jeffery N Talbot; Emily Jutkiewicz; Steven M Graves; Crystal F Clemans; Melanie R Nicol; richard mortensen; Xinyan Huang; Richard Neubig; John R Traynor
RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(24):11086-91.
2010: Jeffery N Talbot; David Roman; Mary J Clark; Rebecca A Roof; John J G Tesmer; Richard Neubig; John R Traynor
Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent.
Journal of neurochemistry 2010;112(4):1026-34.
2010: Chris R Evelyn; Jessica L Bell; Jenny G Ryu; Susan M Wade; Andrew Kocab; Nicole L Harzdorf; H D Hollis Showalter; Richard Neubig; Scott D Larsen
Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.
Bioorganic & medicinal chemistry letters 2010;20(2):665-72.
2010: Andreja Jovic; Bryan Howell; Michelle Cote; Susan M Wade; Khamir Mehta; Atsushi Miyawaki; Richard Neubig; Jennifer J Linderman; Shuichi Takayama
Phase-locked signals elucidate circuit architecture of an oscillatory pathway.
PLoS computational biology 2010;6(12):e1001040.
2010: Benita Sjögren; Levi L Blazer; Richard Neubig
Regulators of G protein signaling proteins as targets for drug discovery.
Progress in molecular biology and translational science 2010;91():81-119.
2010: Levi L Blazer; David Roman; Molly R Muxlow; Richard Neubig
Use of flow cytometric methods to quantify protein-protein interactions.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2010;Chapter 13():Unit 13.11.1-15.
2009: Eduardo E Icaza; Xinyan Huang; Ying Fu; Richard Neubig; Helen A Baghdoyan; Ralph Lydic
Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins.
Anesthesia and analgesia 2009;109(5):1500-5.
2009: Mohamed Aittaleb; Guang Gao; Chris R Evelyn; Richard Neubig; John J G Tesmer
A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.
Cellular signalling 2009;21(11):1569-78.
2009: David Roman; Shodai Ota; Richard Neubig
Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors.
Journal of biomolecular screening 2009;14(6):610-9.
2009: Xinyan Huang; Ying Fu; Raelene A Charbeneau; Richard Neubig
GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism.
Medical hypotheses 2009;73(1):56-9.
2009: Brianna L Goldenstein; Brian W Nelson; Ke Xu; Elizabeth J Luger; Jacquline A Pribula; Jenna M Wald; Lorraine A O'Shea; David Weinshenker; Raelene A Charbeneau; Xinyan Huang; Richard Neubig; Van A Doze
Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity.
Molecular pharmacology 2009;75(5):1222-30.
2009: Weiping Peng; Daniel C Peltier; Martha J Larsen; Paul D Kirchhoff; Scott D Larsen; Richard Neubig; David Miller
Identification of thieno[3,2-b]pyrrole derivatives as novel small molecule inhibitors of neurotropic alphaviruses.
The Journal of infectious diseases 2009;199(7):950-7.
2009: Janet J Maguire; William A E Parker; Steven M Foord; Tom I Bonner; Richard Neubig; Anthony P Davenport
International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.
Pharmacological reviews 2009;61(1):1-8.
2009: Bipasha Guptaroy; Minjia Zhang; Erica Bowton; Francesca Binda; Lei Shi; HAREL WEINSTEIN; Aurelio Galli; Jonathan A Javitch; Richard Neubig; Margaret E Gnegy
A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.
Molecular pharmacology 2009;75(3):514-24.
2009: Chris R Evelyn; Timothy Ferng; Rafael J Rojas; Martha J Larsen; John Sondek; Richard Neubig
High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.
Journal of biomolecular screening 2009;14(2):161-72.
2009: Rebecca A Roof; David Roman; Samuel T Clements; Katarzyna Sobczyk-Kojiro; Levi L Blazer; Shodai Ota; Henry I Mosberg; Richard Neubig
A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen.
BMC pharmacology 2009;9():9.
2009: Anthony J Harmar; Rebecca A Hills; Edward M Rosser; Martin Jones; O Peter Buneman; Donald R Dunbar; Stuart D Greenhill; Valerie A Hale; Joanna L Sharman; Tom I Bonner; William A Catterall; Anthony P Davenport; Philippe Delagrange; Colin T Dollery; Steven M Foord; George A Gutman; Vincent Laudet; Richard Neubig; Eliot H Ohlstein; Richard W Olsen; John Peters; Jean-Philippe Pin; Robert R Ruffolo; David B Searls; Mathew W Wright; Michael Spedding
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Nucleic acids research 2009;37(Database issue):D680-5.
2009: Levi L Blazer; Richard Neubig
Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(1):126-41.
2008: Donald J Bernsteel; David L Roman; Richard Neubig
In vitro protein kinase activity measurement by flow cytometry.
Analytical biochemistry 2008;383(2):180-5.
2008: Aruna Shankaranarayanan; David M Thal; Valerie M Tesmer; David Roman; Richard Neubig; Tohru Kozasa; John J G Tesmer
Assembly of high order G alpha q-effector complexes with RGS proteins.
The Journal of biological chemistry 2008;283(50):34923-34.
2008: Richard Neubig
And the winner is ... RGS4!
Circulation research 2008;103(5):444-6.
2008: Rebecca A Roof; Katarzyna Sobczyk-Kojiro; Anjanette J Turbiak; David Roman; Irina D Pogozheva; Levi L Blazer; Richard Neubig; Henry I Mosberg
Novel peptide ligands of RGS4 from a focused one-bead, one-compound library.
Chemical biology & drug design 2008;72(2):111-9.
2008: Jian Pei; John F Dishinger; David Roman; Chetwana Rungwanitcha; Richard Neubig; Robert T Kennedy
Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system.
Analytical chemistry 2008;80(13):5225-31.
2008: Xinyan Huang; Raelene A Charbeneau; Ying Fu; Kuljeet Kaur; Isabelle Gerin; Ormond A MacDougald; Richard Neubig
Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.
Diabetes 2008;57(1):77-85.
2007: Susanne Lutz; Aruna Shankaranarayanan; Cassandra Coco; Marc Robert Ridilla; Mark R Nance; Christiane Vettel; Doris Baltus; Chris R Evelyn; Richard Neubig; Thomas Wieland; John J G Tesmer
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science (New York, N.Y.) 2007;318(5858):1923-7.
2007: Michael A Flierl; Daniel Rittirsch; Brian A Nadeau; Anthony J Chen; J Vidya Sarma; Firas S Zetoune; Stephanie R McGuire; Rachel P List; Danielle E Day; Laszlo M Hoesel; Hongwei Gao; Nico van Rooijen; Markus Huber-Lang; Richard Neubig; Peter A Ward
Phagocyte-derived catecholamines enhance acute inflammatory injury.
Nature 2007;449(7163):721-5.
2007: Chris R Evelyn; Susan M Wade; Qin Wang; Mei Wu; Jorge A Iniguez-Lluhi; Sofia D Merajver; Richard Neubig
CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.
Molecular cancer therapeutics 2007;6(8):2249-60.
2007: Kannan Vadakkadathmeethal; Jennifer M Cunliffe; Jennifer Swift; Robert T Kennedy ; Richard Neubig; Roger K Sunahara
Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening.
Combinatorial chemistry & high throughput screening 2007;10(4):289-98.
2007: Richard Neubig
Missing links: mechanisms of protean agonism.
Molecular pharmacology 2007;71(5):1200-2.
2007: Ying Fu; Xinyan Huang; Lin Piao; Anatoli N Lopatin; Richard Neubig
Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2532-9.
2007: Johannes Bodenstein; Roger K Sunahara; Richard Neubig
N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.
Molecular pharmacology 2007;71(4):1040-50.
2007: G Enrico Rovati; Valérie Capra; Richard Neubig
The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.
Molecular pharmacology 2007;71(4):959-64.
2007: Jean-Philippe Pin; Richard Neubig; Michel Bouvier; Lakshmi Devi; Marta Filizola; Jonathan A Javitch; Martin J Lohse; Graeme Milligan; Krzysztof Palczewski; Marc Parmentier; Michael Spedding
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.
Pharmacological reviews 2007;59(1):5-13.
2007: Nils Walter; Jens-Christian Meiners; Edgar Meyhofer; Richard Neubig; Roger K Sunahara; Noel C Perkins; Duncan G Steel; Joel A Swanson
Under the microscope: single molecule symposium at the University of Michigan, 2006.
Biopolymers 2007;85(2):106-14.
2007: Emily E Jameson; Jian Pei; Susan M Wade; Richard Neubig; Graeme Milligan; Robert T Kennedy
Capillary electrophoresis assay for G protein-coupled receptor-mediated GTPase activity.
Analytical chemistry 2007;79(3):1158-63.
2007: Lucy Skrabanek; Marta Murcia; Michel Bouvier; Lakshmi Devi; Susan R George; Martin J Lohse; Graeme Milligan; Richard Neubig; Krzysztof Palczewski; Marc Parmentier; Jean-Philippe Pin; Gert Vriend; Jonathan A Javitch; Fabien Campagne; Marta Filizola
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base.
BMC bioinformatics 2007;8():177.
2007: David Roman; Jeffery N Talbot; Rebecca A Roof; Roger K Sunahara; John R Traynor; Richard Neubig
Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay.
Molecular pharmacology 2007;71(1):169-75.
2006: Xinyan Huang; Ying Fu; Raelene A Charbeneau; Thomas L Saunders; Douglas K Taylor; Kurt D Hankenson; Mark W Russell; Louis G D'Alecy; Richard Neubig
Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.
Molecular and cellular biology 2006;26(18):6870-9.
2006: Rebecca A Roof; Yafei Jin; David Roman; Roger K Sunahara; Masaru Ishii; Henry I Mosberg; Richard Neubig
Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins.
Chemical biology & drug design 2006;67(4):266-74.
2006: Ying Fu; Xinyan Huang; Huailing Zhong; richard mortensen; Louis G D'Alecy; Richard Neubig
Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.
Circulation research 2006;98(5):659-66.
2006: Chang-Seon Myung; William K Lim; Joseph M DeFilippo; Hiroshi Yasuda; Richard Neubig; James C Garrison
Regions in the G protein gamma subunit important for interaction with receptors and effectors.
Molecular pharmacology 2006;69(3):877-87.
2005: Anthony P Davenport; Tom Bonner; Steven M Foord; Anthony J Harmar; Richard Neubig; Jean-Philippe Pin; Michael Spedding; Masayasu Kojima; Keniji Kangawa
International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function.
Pharmacological reviews 2005;57(4):541-6.
2005: Bradley S Henson; Richard Neubig; Ilwhan Jang; Tetsuya Ogawa; Zhaocheng Zhang; Thomas Carey; Nisha J D'Silva
Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma.
The Journal of biological chemistry 2005;280(24):22564-71.
2005: Steven M Foord; Tom Bonner; Richard Neubig; Edward M Rosser; Jean-Phillipe Pin; Anthony P Davenport; Michael Spedding; Anthony J Harmar
International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Pharmacological reviews 2005;57(2):279-88.
2005: Biaoxin Chai; Irina D Pogozheva; Yu-Mei Lai; Ji-yao Li; Richard Neubig; Henry I Mosberg; Ira Gantz
Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors.
Biochemistry 2005;44(9):3418-31.
2005: Emily E Jameson; Rebecca A Roof; Matthew R Whorton; Henry I Mosberg; Roger K Sunahara; Richard Neubig; Robert T Kennedy
Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues.
The Journal of biological chemistry 2005;280(9):7712-9.
2005: John R Traynor; Richard Neubig
Regulators of G protein signaling & drugs of abuse.
Molecular interventions 2005;5(1):30-41.
2004: Rebecca J Whelan; Roger K Sunahara; Richard Neubig; Robert T Kennedy
Affinity assays using fluorescence anisotropy with capillary electrophoresis separation.
Analytical chemistry 2004;76(24):7380-6.
2004: Qin Wang; Min Liu; Tohru Kozasa; Jeffrey rothstein; Paul C Sternweis; Richard Neubig
Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.
The Journal of biological chemistry 2004;279(28):28831-4.
2004: Mary J Clark; Richard Neubig; John R Traynor
Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.
The Journal of pharmacology and experimental therapeutics 2004;310(1):215-22.
2004: Peter C Simons; Sean M Biggs; Anna Waller; Terry D Foutz; Daniel F Cimino; Qing Guo; Richard Neubig; Wei-Jen Tang; Eric R Prossnitz; Larry A Sklar
Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction.
The Journal of biological chemistry 2004;279(14):13514-21.
2004: Yafei Jin; Huailing Zhong; John R Omnaas; Richard Neubig; Henry I Mosberg
Structure-based design, synthesis, and pharmacologic evaluation of peptide RGS4 inhibitors.
The journal of peptide research : official journal of the American Peptide Society 2004;63(2):141-6.
2004: Yafei Jin; Huailing Zhong; John R Omnaas; Richard Neubig; Henry I Mosberg
Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity.
Methods in enzymology 2004;389():266-77.
2004: Qin Wang; Min Liu; Tohru Kozasa; Jeffrey D Rothestein; Paul C Sternweis; Richard Neubig
Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins.
Methods in enzymology 2004;389():244-65.
2004: Ying Fu; Huailing Zhong; Masakatsu Nanamori; richard mortensen; Xinyan Huang; Kengli Lan; Richard Neubig
RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins.
Methods in enzymology 2004;389():229-43.
2003: Orkun S Soyer; Matthew W Dimmic; Richard Neubig; Richard A Goldstein
Dimerization in aminergic G-protein-coupled receptors: application of a hidden-site class model of evolution.
Biochemistry 2003;42(49):14522-31.
2003: Richard Neubig; Michael Spedding; Terry Kenakin; Arthur Christopoulos
International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology.
Pharmacological reviews 2003;55(4):597-606.
2003: Bin Qian; Orkun S Soyer; Richard Neubig; Richard A Goldstein
Depicting a protein's two faces: GPCR classification by phylogenetic tree-based HMMs.
FEBS letters 2003;554(1-2):95-9.
2003: Peter C Simons; Mei Shi; Terry D Foutz; Daniel F Cimino; Jeremy Lewis; Tione Buranda; William K Lim; Richard Neubig; William E McIntire; James C Garrison; Eric R Prossnitz; Larry A Sklar
Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.
Molecular pharmacology 2003;64(5):1227-38.
2003: Emily E Jameson; Jennifer M Cunliffe; Richard Neubig; Roger K Sunahara; Robert T Kennedy
Detection of G proteins by affinity probe capillary electrophoresis using a fluorescently labeled GTP analogue.
Analytical chemistry 2003;75(16):4297-304.
2003: Yu Shangguan; Karen E Hall; Richard Neubig; John W Wiley
Diabetic neuropathy: inhibitory G protein dysfunction involves PKC-dependent phosphorylation of Goalpha.
Journal of neurochemistry 2003;86(4):1006-14.
2003: Farida Goubaeva; Mousumi Ghosh; Sundeep Malik; Jay Yang; Patricia M Hinkle; Kathy K Griendling; Richard Neubig; Alan V Smrcka
Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.
The Journal of biological chemistry 2003;278(22):19634-41.
2003: Biaoxin Chai; Richard Neubig; Glenn L Millhauser; Darren Thompson; Pilgrim J Jackson; Gregory S Barsh; Chris J Dickinson; Ji-yao Li; Yu-Mei Lai; Ira Gantz
Inverse agonist activity of agouti and agouti-related protein.
Peptides 2003;24(4):603-9.
2003: Mary J Clark; Charlotte Harrison; Huailing Zhong; Richard Neubig; John R Traynor
Endogenous RGS protein action modulates mu-opioid signaling through Galphao. Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways.
The Journal of biological chemistry 2003;278(11):9418-25.
2003: Huailing Zhong; Susan M Wade; Peter J Woolf; Jennifer J Linderman; John R Traynor; Richard Neubig
A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding.
The Journal of biological chemistry 2003;278(9):7278-84.
2002: Richard Neubig
Regulators of G protein signaling (RGS proteins): novel central nervous system drug targets.
The journal of peptide research : official journal of the American Peptide Society 2002;60(6):312-6.
2002: Noune A Sarvazyan; William K Lim; Richard Neubig
Fluorescence analysis of receptor-G protein interactions in cell membranes.
Biochemistry 2002;41(42):12858-67.
2002: Jong Hyeon Yoo; Young-Sang Yang; Ilkuen Choi; Yu Shangguan; Inseok Song; Richard Neubig; John W Wiley
Expression of novel splice variants of the G protein subunit, Go alpha, is tissue-specific and age-dependent in the rat.
Gene 2002;296(1-2):249-55.
2002: Harvey Motulsky; Richard Neubig
Analyzing radioligand binding data.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2002;Chapter 7():Unit 7.5.
2002: Qin Wang; Min Liu; Bashar Mullah; David Siderovski; Richard Neubig
Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells.
The Journal of biological chemistry 2002;277(28):24949-58.
2002: Duane A Chung; Susan M Wade; Carol B Fowler; Danielle D Woods; Paolo B Abada; Henry I Mosberg; Richard Neubig
Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.
Biochemical and biophysical research communications 2002;293(4):1233-41.
2002: Duane A Chung; Erik R P Zuiderweg; Carol B Fowler; Orkun S Soyer; Henry I Mosberg; Richard Neubig
NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.
Biochemistry 2002;41(11):3596-604.
2002: Koichi Seta; Masakatsu Nanamori; J Gregory Modrall; Richard Neubig; Junichi Sadoshima
AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs.
The Journal of biological chemistry 2002;277(11):9268-77.
2002: Richard Neubig; David Siderovski
Regulators of G-protein signalling as new central nervous system drug targets.
Nature reviews. Drug discovery 2002;1(3):187-97.
2002: Orkun S Soyer; Matthew W Dimmic; Richard Neubig; Richard A Goldstein
Using evolutionary methods to study G-protein coupled receptors.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2002;():625-36.
2002: Dyke P McEwen; Kyle R Gee; Hee C Kang; Richard Neubig
Fluorescence approaches to study G protein mechanisms.
Methods in enzymology 2002;344():403-20.
2001: William K Lim; Chang-Seon Myung; James C Garrison; Richard Neubig
Receptor-G protein gamma specificity: gamma11 shows unique potency for A(1) adenosine and 5-HT(1A) receptors.
Biochemistry 2001;40(35):10532-41.
2001: J Gregory Modrall; Masakatsu Nanamori; J Sadoshima; D C Barnhart; James C Stanley; Richard Neubig
ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling.
American journal of physiology. Cell physiology 2001;281(3):C801-9.
2001: Teresa A Bennett; T Alexander Key; Vsevolod V Gurevich; Richard Neubig; Eric R Prossnitz; Larry A Sklar
Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system.
The Journal of biological chemistry 2001;276(25):22453-60.
2001: Huailing Zhong; Richard Neubig
Regulator of G protein signaling proteins: novel multifunctional drug targets.
The Journal of pharmacology and experimental therapeutics 2001;297(3):837-45.
2001: H Motulsky; Richard Neubig
Analyzing radioligand binding data.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Appendix 3():Appendix 3H.
2001: Dyke P McEwen; Kyle R Gee; H C Kang; Richard Neubig
Fluorescent BODIPY-GTP analogs: real-time measurement of nucleotide binding to G proteins.
Analytical biochemistry 2001;291(1):109-17.
2001: Philip E Lapinski; Richard Neubig; Malini Raghavan
Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.
The Journal of biological chemistry 2001;276(10):7526-33.
2001: Susan M Wade; Kengli Lan; D J Moore; Richard Neubig
Inverse agonist activity at the alpha(2A)-adrenergic receptor.
Molecular pharmacology 2001;59(3):532-42.
2001: William K Lim; Richard Neubig
Selective inactivation of guanine-nucleotide-binding regulatory protein (G-protein) alpha and betagamma subunits by urea.
The Biochemical journal 2001;354(Pt 2):337-44.
2001: I K Park; C A Klug; K Li; L Jerabek; Linheng Li; Masakatsu Nanamori; Richard Neubig; Leroy Hood; I L Weissman; Michael F Clarke
Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells.
The Journal of biological chemistry 2001;276(2):915-23.
2000: L D Shea; Richard Neubig; J J Linderman
Timing is everything the role of kinetics in G protein activation.
Life sciences 2000;68(6):647-58.
2000: KL Lan; Huailing Zhong; Masakatsu Nanamori; Richard Neubig
Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7.
The Journal of biological chemistry 2000;275(43):33497-503.
2000: L Stanasila; W K Lim; Richard Neubig; Franc Pattus
Coupling efficacy and selectivity of the human mu-opioid receptor expressed as receptor-Galpha fusion proteins in Escherichia coli.
Journal of neurochemistry 2000;75(3):1190-9.
2000: C B Brink; Susan M Wade; Richard Neubig
Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).
The Journal of pharmacology and experimental therapeutics 2000;294(2):539-47.
2000: Susan M Sullivan; R Mishra; Richard Neubig; Janine R Maddock
Analysis of guanine nucleotide binding and exchange kinetics of the Escherichia coli GTPase Era.
Journal of bacteriology 2000;182(12):3460-6.
1999: Susan M Wade; William K Lim; KL Lan; Duane A Chung; Masakatsu Nanamori; Richard Neubig
G(i) activator region of alpha(2A)-adrenergic receptors: distinct basic residues mediate G(i) versus G(s) activation.
Molecular pharmacology 1999;56(5):1005-13.
1999: Ann E Remmers; C Engel; M Liu; Richard Neubig
Interdomain interactions regulate GDP release from heterotrimeric G proteins.
Biochemistry 1999;38(42):13795-800.
1998: KL Lan; Noune A Sarvazyan; Ronald Taussig; Robert George MacKenzie; PR DiBello; Henrik G Dohlman; Richard Neubig
A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins.
The Journal of biological chemistry 1998;273(21):12794-7.
1998: Noune A Sarvazyan; Ann E Remmers; Richard Neubig
Determinants of gi1alpha and beta gamma binding. Measuring high affinity interactions in a lipid environment using flow cytometry.
The Journal of biological chemistry 1998;273(14):7934-40.
1998: J B Thompson; Susan M Wade; Jeffrey K Harrison; MN Salafranca; Richard Neubig
Cotransfection of second and third intracellular loop fragments inhibit angiotensin AT1a receptor activation of phospholipase C in HEK-293 cells.
The Journal of pharmacology and experimental therapeutics 1998;285(1):216-22.
1998: KL Lan; Ann E Remmers; Richard Neubig
Roles of G(o)alpha tryptophans in GTP hydrolysis, GDP release, and fluorescence signals.
Biochemistry 1998;37(3):837-43.
1997: M Zhu; Richard Neubig; Susan M Wade; P Posner; Craig H Gelband; Colin Sumners
Modulation of K+ and Ca2+ currents in cultured neurons by an angiotensin II type 1a receptor peptide.
The American journal of physiology 1997;273(3 Pt 1):C1040-8.
1997: Palmer Taylor; Elliott M Ross; Paul C Sternweis; Richard Neubig; J Andrew McCammon
Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997).
Molecular pharmacology 1997;52(1):1-5.
1997: María A Diversé-Pierluissi; Ann E Remmers; Richard Neubig; Kathleen Dunlap
Novel form of crosstalk between G protein and tyrosine kinase pathways.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5417-21.
1996: Susan M Wade; M K Scribner; H M Dalman; Joan M Taylor; Richard Neubig
Structural requirements for G(o) activation by receptor-derived peptides: activation and modulation domains of the alpha 2-adrenergic receptor i3c region.
Molecular pharmacology 1996;50(2):351-8.
1996: R M Graham; Richard Neubig; K R Lynch
alpha 2-Adrenoceptors take centre stage at Nashville meeting.
Trends in pharmacological sciences 1996;17(3):90-4.
1996: Ann E Remmers; Richard Neubig
Partial G protein activation by fluorescent guanine nucleotide analogs. Evidence for a triphosphate-bound but inactive state.
The Journal of biological chemistry 1996;271(9):4791-7.
1996: Joan M Taylor; G G Jacob-Mosier; R G Lawton; Marcian E Van Dort; Richard Neubig
Receptor and membrane interaction sites on Gbeta. A receptor-derived peptide binds to the carboxyl terminus.
The Journal of biological chemistry 1996;271(7):3336-9.
1995: E P Marin; Richard Neubig
Lack of association of G-protein beta 2- and gamma 2-subunit N-terminal fragments provides evidence against the coiled-coil model of subunit-beta gamma assembly.
The Biochemical journal 1995;309 ( Pt 2)():377-80.
1995: Sverre E Kjeldsen; Alan B Weder; Brent M Egan; Richard Neubig; AJ Zweifler; Stevo Julius
Effect of circulating epinephrine on platelet function and hematocrit.
Hypertension 1995;25(5):1096-105.
1994: Richard Neubig; M P Connolly; Ann E Remmers
Rapid kinetics of G protein subunit association: a rate-limiting conformational change?
FEBS letters 1994;355(3):251-3.
1994: S Uhlén; A C Porter; Richard Neubig
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1558-65.
1994: Joan M Taylor; G G Jacob-Mosier; R G Lawton; Ann E Remmers; Richard Neubig
Binding of an alpha 2 adrenergic receptor third intracellular loop peptide to G beta and the amino terminus of G alpha.
The Journal of biological chemistry 1994;269(44):27618-24.
1994: Joan M Taylor; Richard Neubig
Peptides as probes for G protein signal transduction.
Cellular signalling 1994;6(8):841-9.
1994: Richard Neubig
Membrane organization in G-protein mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(12):939-46.
1994: G Kwon; Daniel Axelrod; Richard Neubig
Lateral mobility of tetramethylrhodamine (TMR) labelled G protein alpha and beta gamma subunits in NG 108-15 cells.
Cellular signalling 1994;6(6):663-79.
1994: Susan M Wade; H M Dalman; S Z Yang; Richard Neubig
Multisite interactions of receptors and G proteins: enhanced potency of dimeric receptor peptides in modifying G protein function.
Molecular pharmacology 1994;45(6):1191-7.
1994: Ann E Remmers; Richard G Posner; Richard Neubig
Fluorescent guanine nucleotide analogs and G protein activation.
The Journal of biological chemistry 1994;269(19):13771-8.
1994: Joan M Taylor; G G Jacob-Mosier; R G Lawton; Richard Neubig
Coupling an alpha 2-adrenergic receptor peptide to G-protein: a new photolabeling agent.
Peptides 1994;15(5):829-34.
1993: Richard Neubig; L A Sklar
Subsecond modulation of formyl peptide-linked guanine nucleotide-binding proteins by guanosine 5'-O-(3-thio)triphosphate in permeabilized neutrophils.
Molecular pharmacology 1993;43(5):734-40.
1993: G Kwon; Ann E Remmers; S Datta; Richard Neubig
Synthesis and characterization of fluorescently labeled bovine brain G protein subunits.
Biochemistry 1993;32(9):2401-8.
1993: Ann E Remmers; Richard Neubig
Resonance energy transfer between guanine nucleotide binding protein subunits and membrane lipids.
Biochemistry 1993;32(9):2409-14.
1993: D Graeser; Richard Neubig
Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors.
Molecular pharmacology 1993;43(3):434-43.
1992: Geneva M Omann; J M Harter; N Hassan; Pamela J Mansfield; SJ Suchard; Richard Neubig
A threshold level of coupled G-proteins is required to transduce neutrophil responses.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):2172-8.
1992: L A Mangels; Richard Neubig; H E Hamm; Margaret E Gnegy
Calmodulin binding distinguishes between beta gamma subunits of activated G proteins and transducin.
The Biochemical journal 1992;283 ( Pt 3)():683-90.
1991: M A Gerhardt; Richard Neubig
Multiple Gi protein subtypes regulate a single effector mechanism.
Molecular pharmacology 1991;40(5):707-11.
1991: H M Dalman; Richard Neubig
Two peptides from the alpha 2A-adrenergic receptor alter receptor G protein coupling by distinct mechanisms.
The Journal of biological chemistry 1991;266(17):11025-9.
1990: M A Sekkarie; Brent M Egan; Richard Neubig; Mark A Supiano
Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate.
Clinical pharmacology and therapeutics 1990;48(5):537-43.
1990: M A Gerhardt; Susan M Wade; Richard Neubig
p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor.
Molecular pharmacology 1990;38(2):214-21.
1990: Mark A Zamorski; J C Ferraro; Richard Neubig
Subcellular distribution of alpha 2-adrenergic receptors, pertussis-toxin substrate and adenylate cyclase in human platelets.
The Biochemical journal 1990;265(3):755-62.
1990: Martin C Michel; John W Regan; M A Gerhardt; Richard Neubig; Paul Insel; H J Motulsky
Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors.
Molecular pharmacology 1990;37(1):65-8.
1989: Sverre E Kjeldsen; Richard Neubig; Alan B Weder; AJ Zweifler
The hypertension-coronary heart disease dilemma: the catecholamine-blood platelet connection.
Journal of hypertension 1989;7(11):851-60.
1989: Richard Neubig; W J Thomsen
How does a key fit a flexible lock? Structure and dynamics in receptor function.
BioEssays : news and reviews in molecular, cellular and developmental biology 1989;11(5):136-41.
1989: W J Thomsen; Richard Neubig
Rapid kinetics of alpha 2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step.
Biochemistry 1989;28(22):8778-86.
1989: Mark A Supiano; Richard Neubig; O A Linares; Jeffrey B Halter; S G Rosen
Effects of low-sodium diet on regulation of platelet alpha 2-adrenergic receptors in young and elderly humans.
The American journal of physiology 1989;256(3 Pt 1):E339-44.
1988: W J Thomsen; John A Jacquez; Richard Neubig
Inhibition of adenylate cyclase is mediated by the high affinity conformation of the alpha 2-adrenergic receptor.
Molecular pharmacology 1988;34(6):814-22.
1988: R D Gantzos; Richard Neubig
Temperature effects on alpha 2-adrenergic receptor-Gi interactions.
Biochemical pharmacology 1988;37(14):2815-21.
1988: Richard Neubig; R D Gantzos; W J Thomsen
Mechanism of agonist and antagonist binding to alpha 2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex.
Biochemistry 1988;27(7):2374-84.
1987: Marcian E Van Dort; Richard Neubig; Raymond E Counsell
Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor.
Journal of medicinal chemistry 1987;30(7):1241-4.
1987: M H Kim; Richard Neubig
Membrane reconstitution of high-affinity alpha 2 adrenergic agonist binding with guanine nucleotide regulatory proteins.
Biochemistry 1987;26(12):3664-72.
1986: Mary A Bittner; Ronald W Holz; Richard Neubig
Guanine nucleotide effects on catecholamine secretion from digitonin-permeabilized adrenal chromaffin cells.
The Journal of biological chemistry 1986;261(22):10182-8.
1986: Richard Neubig; O Szamraj
Large-scale purification of alpha 2-adrenergic receptor-enriched membranes from human platelets. Persistent association of guanine nucleotides with nonpurified membranes.
Biochimica et biophysica acta 1986;854(1):67-76.
1985: M H Kim; Richard Neubig
Parallel inactivation of alpha 2-adrenergic agonist binding and Ni by alkaline treatment.
FEBS letters 1985;192(2):321-5.
1985: Brent M Egan; Richard Neubig; Stevo Julius
Pharmacologic reduction of sympathetic drive increases platelet alpha-2-receptor number.
Clinical pharmacology and therapeutics 1985;38(5):519-24.
1985: Richard Neubig; R D Gantzos; R S Brasier
Agonist and antagonist binding to alpha 2-adrenergic receptors in purified membranes from human platelets. Implications of receptor-inhibitory nucleotide-binding protein stoichiometry.
Molecular pharmacology 1985;28(5):475-86.
1985: Brent M Egan; Richard Neubig; Robert H Schneider; Stevo Julius
Methods for measuring vascular and nonvascular alpha-receptor sensitivity in humans.
Journal of cardiovascular pharmacology 1985;7 Suppl 6():S153-8.
1982: Richard Neubig; N D Boyd; jonathan cohen
Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization.
Biochemistry 1982;21(14):3460-7.
1981: Stanley Froehner; V Gulbrandsen; C Hyman; A Y Jeng; Richard Neubig; jonathan cohen
Immunofluorescence localization at the mammalian neuromuscular junction of the Mr 43,000 protein of Torpedo postsynaptic membranes.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(8):5230-4.
1980: Richard Neubig; jonathan cohen
Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times.
Biochemistry 1980;19(12):2770-9.
1979: Richard Neubig; jonathan cohen
Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by Torpedo postsynaptic membranes: stoichiometry and ligand interactions.
Biochemistry 1979;18(24):5464-75.
1979: Richard Neubig; E K Krodel; N D Boyd; jonathan cohen
Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(2):690-4.
1975: Richard Neubig; S W Hoobler
Reversal of chronic renal hypertension: role of salt and water excretion.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1975;150(1):254-6.