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Craig Bula

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Mathew T Mizwicki; Craig M Bula; Paween Mahinthichaichan; Helen L Henry; Seiichi Ishizuka; Anthony W Norman
On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist.
Changhui Deng; Eric Kinnosuke Martins Ueda; Kuanhui E Chen; Craig M Bula; Anthony W Norman; Richard A Luben; Ameae M Walker
Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells.
Craig M Bula; June E Bishop; Anthony W Norman
Conservative mutageneic perturbations of amino acids connecting helix 12 in the 1alpha,25(OH)2-D3 receptor (VDR) to the ligand cause significant transactivational effects.

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All Publications

2009: Mathew T Mizwicki; Craig M Bula; Paween Mahinthichaichan; Helen L Henry; Seiichi Ishizuka; Anthony W Norman
On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist.
The Journal of biological chemistry 2009;284(52):36292-301.
2009: Changhui Deng; Eric Kinnosuke Martins Ueda; Kuanhui E Chen; Craig M Bula; Anthony W Norman; Richard A Luben; Ameae M Walker
Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells.
Molecular endocrinology (Baltimore, Md.) 2009;23(2):226-36.
2007: Craig M Bula; June E Bishop; Anthony W Norman
Conservative mutageneic perturbations of amino acids connecting helix 12 in the 1alpha,25(OH)2-D3 receptor (VDR) to the ligand cause significant transactivational effects.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):286-92.
2007: Mathew T Mizwicki; Craig M Bula; June E Bishop; Anthony W Norman
New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):243-62.
2005: Craig M Bula; Johanna Huhtakangas; Christopher J Olivera; June E Bishop; Anthony W Norman; Helen L Henry
Presence of a truncated form of the vitamin D receptor (VDR) in a strain of VDR-knockout mice.
Endocrinology 2005;146(12):5581-6.
2005: Mathew T Mizwicki; Craig M Bula; June E Bishop; Anthony W Norman
A perspective on how the Vitamin D sterol/Vitamin D receptor (VDR) conformational ensemble model can potentially be used to understand the structure-function results of A-ring modified Vitamin D sterols.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):69-82.
2005: Anthony M Vertino; Craig M Bula; Jin-Ran Chen; Maria Almeida; Li Han; Teresita Bellido; Stavroula Kousteni; Anthony W Norman; Stavros C Manolagas
Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.
The Journal of biological chemistry 2005;280(14):14130-7.
2005: Elaine D Collins; June E Bishop; Craig M Bula; Alejandra Acevedo; William H Okamura; Anthony W Norman
Effect of 25-hydroxyl group orientation on biological activity and binding to the 1alpha,25-dihydroxy vitamin D3 receptor.
The Journal of steroid biochemistry and molecular biology 2005;94(4):279-88.
2004: Mathew T Mizwicki; Don Keidel; Craig M Bula; June E Bishop; Laura P Zanello; Jean-Marie Wurtz; Dino Moras; Anthony W Norman
Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):12876-81.
2004: Christopher J Olivera; Craig M Bula; June E Bishop; Luciano Adorini; Percy Manchand; Milan R Uskokovic; Anthony W Norman
Characterization of five 19-nor-analogs of 1alpha,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic properties.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):99-106.
2002: Anthony W Norman; June E Bishop; Craig M Bula; Christopher J Olivera; Mathew T Mizwicki; Laura P Zanello; Hitoshi Ishida; William H Okamura
Molecular tools for study of genomic and rapid signal transduction responses initiated by 1 alpha,25(OH)(2)-vitamin D(3).
Steroids 2002;67(6):457-66.
2001: Anthony W Norman; Helen L Henry; June E Bishop; X D Song; Craig M Bula; William H Okamura
Different shapes of the steroid hormone 1alpha,25(OH)(2)-vitamin D(3) act as agonists for two different receptors in the vitamin D endocrine system to mediate genomic and rapid responses.
Steroids 2001;66(3-5):147-58.
2000: Craig M Bula; June E Bishop; Seiichi Ishizuka; Anthony W Norman
25-Dehydro-1alpha-hydroxyvitamin D3-26,23S-lactone antagonizes the nuclear vitamin D receptor by mediating a unique noncovalent conformational change.
Molecular endocrinology (Baltimore, Md.) 2000;14(11):1788-96.
2000: Y Nie; H H Li; Craig M Bula; Xuan Liu
Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization.
Molecular and cellular biology 2000;20(3):741-8.
1999: Anthony W Norman; X Song; Laura P Zanello; Craig M Bula; William H Okamura
Rapid and genomic biological responses are mediated by different shapes of the agonist steroid hormone, 1alpha,25(OH)2vitamin D3.
Steroids 1999;64(1-2):120-8.