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Michael Roth

Research Profile

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TOP 3
Cheng-Yang Wu; Noelle Williams; Eduardo R Cardenas; Jef K De Brabander; Yu Feng; Paul E Floreancig; Michael Roth
Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.
Samuel E Ward; Katarzyna M Blazewska; Beatriz M A Fontoura; Christian V Forst; Adolfo García-Sastre; Hyun Seok Kim; Kakajan Komurov; Balaji Manicassamy; Charles E McKenna; Saurabh Mendiratta; Michael Roth; Neal Satterly; Mirco Schmolke; Pei-Ling Tsai; Michael A White
Host modulators of H1N1 cytopathogenicity.
Balajee R Somalinga; Cameron E Day; Michael Roth; Shuguang Wei; Philip J Thomas
TDP-43 identified from a genome wide RNAi screen for SOD1 regulators.

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All Publications

2012: Cheng-Yang Wu; Noelle Williams; Eduardo R Cardenas; Jef K De Brabander; Yu Feng; Paul E Floreancig; Michael Roth
Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.
Journal of the American Chemical Society 2012;134(46):18998-9003.
2012: Samuel E Ward; Katarzyna M Blazewska; Beatriz M A Fontoura; Christian V Forst; Adolfo García-Sastre; Hyun Seok Kim; Kakajan Komurov; Balaji Manicassamy; Charles E McKenna; Saurabh Mendiratta; Michael Roth; Neal Satterly; Mirco Schmolke; Pei-Ling Tsai; Michael A White
Host modulators of H1N1 cytopathogenicity.
PloS one 2012;7(8):e39284.
2012: Balajee R Somalinga; Cameron E Day; Michael Roth; Shuguang Wei; Philip J Thomas
TDP-43 identified from a genome wide RNAi screen for SOD1 regulators.
PloS one 2012;7(4):e35818.
2010: Iryna O Zubovych; Sarah Straud; Michael Roth
Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans.
Molecular biology of the cell 2010;21(6):956-69.
2010: Sarah Straud; Iryna Zubovych; Jef K De Brabander; Michael Roth
Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines.
PloS one 2010;5(7):e11629.
2008: Sylvain Lebreton; Janis Jaunbergs; Michael Roth; Deborah A Ferguson; Jef K De Brabander
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
Bioorganic & medicinal chemistry letters 2008;18(22):5879-83.
2008: Michael Roth
Molecular mechanisms of PLD function in membrane traffic.
Traffic (Copenhagen, Denmark) 2008;9(8):1233-9.
2008: Michael Roth
Cell biology: porter and sorter.
Nature 2008;452(7188):706-7.
2007: David Padrón; Mitsuo Sato; Jerry W Shay; Adi F Gazdar; John D Minna; Michael Roth
Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized.
Cancer research 2007;67(16):7695-702.
2007: Michael Roth
Integrating actin assembly and endocytosis.
Developmental cell 2007;13(1):3-4.
2007: Angelique Whitehurst; Brian O Bodemann; Jessica Cardenas; Deborah Ferguson; Luc Girard; Michael Peyton; John D Minna; Carolyn H Michnoff; Weihua Hao; Michael Roth; Xian-Jin Xie; Michael A White
Synthetic lethal screen identification of chemosensitizer loci in cancer cells.
Nature 2007;446(7137):815-9.
2006: Iryna Zubovych; Thomas Doundoulakis; Patrick G Harran; Michael Roth
A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15523-8.
2006: David Padrón; Renee D Tall; Michael Roth
Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors.
Molecular biology of the cell 2006;17(2):598-606.
2006: Michael Roth
Clathrin-mediated endocytosis before fluorescent proteins.
Nature reviews. Molecular cell biology 2006;7(1):63-8.
2005: Jeffrey Baldwin; Carolyn H Michnoff; Nicholas A Malmquist; John White; Michael Roth; Pradipsinh K Rathod; Margaret A Phillips
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
The Journal of biological chemistry 2005;280(23):21847-53.
2005: Radosveta P Koldamova; Iliya Lefterov; Matthias Staufenbiel; Darren Wolfe; Shaohua Huang; Joseph C Glorioso; Michael Walter; Michael Roth; John Lazo
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.
The Journal of biological chemistry 2005;280(6):4079-88.
2004: Michael Roth
Phosphoinositides in constitutive membrane traffic.
Physiological reviews 2004;84(3):699-730.
2004: Michael Walter; Nicholas R Forsyth; Woodring E Wright; Jerry W Shay; Michael Roth
The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway.
The Journal of biological chemistry 2004;279(20):20866-73.
2004: Xiao-Song Xie; David Padron; Xibin Liao; Jin Wang; Michael Roth; Jef K De Brabander
Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1.
The Journal of biological chemistry 2004;279(19):19755-63.
2004: Delia J Hernández-Deviez; Michael Roth; James E Casanova; Jean M Wilson
ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha.
Molecular biology of the cell 2004;15(1):111-20.
2003: Renee D Tall; Miguel A Alonso; Michael Roth
Features of influenza HA required for apical sorting differ from those required for association with DRMs or MAL.
Traffic (Copenhagen, Denmark) 2003;4(12):838-49.
2003: Dmitry Shvartsman; Mariana Kotler; Renee D Tall; Michael Roth; Yoav I Henis
Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts.
The Journal of cell biology 2003;163(4):879-88.
2003: David Padrón; Ying Jie Wang; Masaya Yamamoto; Helen Yin; Michael Roth
Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis.
The Journal of cell biology 2003;162(4):693-701.
2003: Ying Jie Wang; Jing Wang; Hui-Qiao Sun; Manuel Martinez; Yu Xiao Sun; Eric Macia; Tomas Kirchhausen; Joseph P Albanesi; Michael Roth; Helen L Yin
Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi.
Cell 2003;114(3):299-310.
2002: Sidney Yu; Michael Roth
Casein kinase I regulates membrane binding by ARF GAP1.
Molecular biology of the cell 2002;13(8):2559-70.
2001: John M Lucocq; Maria Manifava; K Bi; Michael Roth; Nicholas T Ktistakis
Immunolocalisation of phospholipase D1 on tubular vesicular membranes of endocytic and secretory origin.
European journal of cell biology 2001;80(8):508-20.
2001: Tzvia Keren; Michael Roth; Yoav I Henis
Internalization-competent influenza hemagglutinin mutants form complexes with clathrin-deficient multivalent AP-2 oligomers in live cells.
The Journal of biological chemistry 2001;276(30):28356-63.
2001: Shamshad Cockcroft; K Bi; Nicholas T Ktistakis; Michael Roth
Biological properties and measurement of phospholipase D activation by ADP-ribosylation factor (ARF).
Methods in enzymology 2001;329():355-72.
2000: Gregory Melikian; Ruben M Markosyan; Michael Roth; Fredric S Cohen
A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion.
Molecular biology of the cell 2000;11(11):3765-75.
2000: Andrew L Rozelle; L M Machesky; Masaya Yamamoto; M H Driessens; R H Insall; Michael Roth; Kate Luby-Phelps; G Marriott; Alan Hall; Helen L Yin
Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.
Current biology : CB 2000;10(6):311-20.
2000: C M Lewis; K Latham; Michael Roth
A screen of random sequences for those that alter the trafficking of the influenza virus hemagglutinin in vivo.
Traffic (Copenhagen, Denmark) 2000;1(3):282-90.
1999: Michael Roth
Inheriting the Golgi.
Cell 1999;99(6):559-62.
1999: CM Brown; Michael Roth; Yoav I Henis; Nils O Petersen
An internalization-competent influenza hemagglutinin mutant causes the redistribution of AP-2 to existing coated pits and is colocalized with AP-2 in clathrin free clusters.
Biochemistry 1999;38(46):15166-73.
1999: Nicholas T Ktistakis; Maria Manifava; Jane M Sugars; K Bi; Michael Roth
Cellular expression and function of phospholipase D1.
Biochemical Society transactions 1999;27(4):634-7.
1999: Gregory Melikian; S Lin; Michael Roth; Fredric S Cohen
Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion.
Molecular biology of the cell 1999;10(6):1821-36.
1999: Michael Roth
Lipid regulators of membrane traffic through the Golgi complex.
Trends in cell biology 1999;9(5):174-9.
1999: Michael Roth
Snapshots of ARF1: implications for mechanisms of activation and inactivation.
Cell 1999;97(2):149-52.
1999: Michael Roth; K Bi; Nicholas T Ktistakis; S Yu
Phospholipase D as an effector for ADP-ribosylation factor in the regulation of vesicular traffic.
Chemistry and physics of lipids 1999;98(1-2):141-52.
1999: Ralf Jacob; U Preuss; P Panzer; Marwan Alfalah; S Quack; Michael Roth; Hassan Y Naim; H Y Naim
Hierarchy of sorting signals in chimeras of intestinal lactase-phlorizin hydrolase and the influenza virus hemagglutinin.
The Journal of biological chemistry 1999;274(12):8061-7.
1999: K A Melkonian; Anne G Ostermeyer; J Z Chen; Michael Roth; Deborah A Brown
Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.
The Journal of biological chemistry 1999;274(6):3910-7.
1998: DL Roush; Cara J Gottardi; Hassan Y Naim; Michael Roth; Michael J Caplan
Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells.
The Journal of biological chemistry 1998;273(41):26862-9.
1998: S Lin; Hassan Y Naim; A C Rodriguez; Michael Roth
Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cells.
The Journal of cell biology 1998;142(1):51-7.
1998: Suzanne M J Fleiszig; V Vallas; C H Jun; L Mok; D F Balkovetz; Michael Roth; Keith E Mostov
Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor.
Infection and immunity 1998;66(7):3443-6.
1997: E Fire; C M Brown; Michael Roth; Yoav I Henis; Nils O Petersen
Partitioning of proteins into plasma membrane microdomains. Clustering of mutant influenza virus hemagglutinins into coated pits depends on the strength of the internalization signal.
The Journal of biological chemistry 1997;272(47):29538-45.
1997: S Lin; Hassan Y Naim; Michael Roth
Tyrosine-dependent basolateral sorting signals are distinct from tyrosine-dependent internalization signals.
The Journal of biological chemistry 1997;272(42):26300-5.
1997: P Scheiffele; Michael Roth; Kai Simons
Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain.
The EMBO journal 1997;16(18):5501-8.
1997: Michael Roth; Paul C Sternweis
The role of lipid signaling in constitutive membrane traffic.
Current opinion in cell biology 1997;9(4):519-26.
1997: K Bi; Michael Roth; Nicholas T Ktistakis
Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex.
Current biology : CB 1997;7(5):301-7.
1996: J Lazarovits; Hassan Y Naim; A C Rodriguez; R H Wang; E Fire; C Bird; Yoav I Henis; Michael Roth
Endocytosis of chimeric influenza virus hemagglutinin proteins that lack a cytoplasmic recognition feature for coated pits.
The Journal of cell biology 1996;134(2):339-48.
1996: Nicholas T Ktistakis; H A Brown; M G Waters; Paul C Sternweis; Michael Roth
Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.
The Journal of cell biology 1996;134(2):295-306.
1996: T Yoshimori; Philipp Keller; Michael Roth; Kai Simons
Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells.
The Journal of cell biology 1996;133(2):247-56.
1996: D E Zwart; C B Brewer; J Lazarovits; Yoav I Henis; Michael Roth
Degradation of mutant influenza virus hemagglutinins is influenced by cytoplasmic sequences independent of internalization signals.
The Journal of biological chemistry 1996;271(2):907-17.
1995: E Fire; O Gutman; Michael Roth; Yoav I Henis
Dynamic or stable interactions of influenza hemagglutinin mutants with coated pits. Dependence on the internalization signal but not on aggregation.
The Journal of biological chemistry 1995;270(36):21075-81.
1995: Hassan Y Naim; D T Dodds; C B Brewer; Michael Roth
Apical and basolateral coated pits of MDCK cells differ in their rates of maturation into coated vesicles, but not in the ability to distinguish between mutant hemagglutinin proteins with different internalization signals.
The Journal of cell biology 1995;129(5):1241-50.
1995: Nicholas T Ktistakis; H A Brown; Paul C Sternweis; Michael Roth
Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4952-6.
1995: Nicholas T Ktistakis; C Y Kao; R H Wang; Michael Roth
A fluorescent lipid analogue can be used to monitor secretory activity and for isolation of mammalian secretion mutants.
Molecular biology of the cell 1995;6(2):135-50.
1995: C B Brewer; Michael Roth
Polarized exocytosis in MDCK cells is regulated by phosphorylation.
Journal of cell science 1995;108 ( Pt 2)():789-96.
1994: D C Thomas; Michael Roth
The basolateral targeting signal in the cytoplasmic domain of glycoprotein G from vesicular stomatitis virus resembles a variety of intracellular targeting motifs related by primary sequence but having diverse targeting activities.
The Journal of biological chemistry 1994;269(22):15732-9.
1994: Hassan Y Naim; Michael Roth
Characteristics of the internalization signal in the Y543 influenza virus hemagglutinin suggest a model for recognition of internalization signals containing tyrosine.
The Journal of biological chemistry 1994;269(6):3928-33.
1994: Hassan Y Naim; Michael Roth
SV40 virus expression vectors.
Methods in cell biology 1994;43 Pt A():113-36.
1993: Hassan Y Naim; Michael Roth
Basis for selective incorporation of glycoproteins into the influenza virus envelope.
Journal of virology 1993;67(8):4831-41.
1993: D C Thomas; C B Brewer; Michael Roth
Vesicular stomatitis virus glycoprotein contains a dominant cytoplasmic basolateral sorting signal critically dependent upon a tyrosine.
The Journal of biological chemistry 1993;268(5):3313-20.
1992: Hassan Y Naim; B Amarneh; Nicholas T Ktistakis; Michael Roth
Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin.
Journal of virology 1992;66(12):7585-8.
1992: Jian-Yun Dong; Michael Roth; Eric Hunter
A chimeric avian retrovirus containing the influenza virus hemagglutinin gene has an expanded host range.
Journal of virology 1992;66(12):7374-82.
1992: C T Okamoto; S P Shia; C Bird; Keith E Mostov; Michael Roth
The cytoplasmic domain of the polymeric immunoglobulin receptor contains two internalization signals that are distinct from its basolateral sorting signal.
The Journal of biological chemistry 1992;267(14):9925-32.
1992: Nicholas T Ktistakis; Maurine E Linder; Michael Roth
Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein.
Nature 1992;356(6367):344-6.
1991: E Fire; D E Zwart; Michael Roth; Yoav I Henis
Evidence from lateral mobility studies for dynamic interactions of a mutant influenza hemagglutinin with coated pits.
The Journal of cell biology 1991;115(6):1585-94.
1991: C B Brewer; Michael Roth
A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin.
The Journal of cell biology 1991;114(3):413-21.
1991: Nicholas T Ktistakis; Michael Roth; George S Bloom
PtK1 cells contain a nondiffusible, dominant factor that makes the Golgi apparatus resistant to brefeldin A.
The Journal of cell biology 1991;113(5):1009-23.
1990: Nicholas T Ktistakis; D Thomas; Michael Roth
Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.
The Journal of cell biology 1990;111(4):1393-407.
1990: J Lazarovits; S P Shia; Nicholas T Ktistakis; M S Lee; C Bird; Michael Roth
The effects of foreign transmembrane domains on the biosynthesis of the influenza virus hemagglutinin.
The Journal of biological chemistry 1990;265(8):4760-7.
1989: S A Stein; Douglas Shanklin; L Krulich; Michael Roth; C M Chubb; P M Adams
Evaluation and characterization of the hyt/hyt hypothyroid mouse. II. Abnormalities of TSH and the thyroid gland.
Neuroendocrinology 1989;49(5):509-19.
1989: J E Skibbens; Michael Roth; K S Matlin
Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts.
The Journal of cell biology 1989;108(3):821-32.
1989: Michael Roth
Molecular biological approaches to protein sorting.
Annual review of physiology 1989;51():797-810.
1987: Michael Roth; D Gundersen; N Patil; Enrique Rodriguez-Boulan
The large external domain is sufficient for the correct sorting of secreted or chimeric influenza virus hemagglutinins in polarized monkey kidney cells.
The Journal of cell biology 1987;104(3):769-82.
1986: Michael Roth; C Doyle; J Sambrook; M J Gething
Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway.
The Journal of cell biology 1986;102(4):1271-83.
1985: C Doyle; Michael Roth; J Sambrook; M J Gething
Mutations in the cytoplasmic domain of the influenza virus hemagglutinin affect different stages of intracellular transport.
The Journal of cell biology 1985;100(3):704-14.
1983: Michael Roth; Richard W Compans; L Giusti; A R Davis; D P Nayak; M J Gething; J Sambrook
Influenza virus hemagglutinin expression is polarized in cells infected with recombinant SV40 viruses carrying cloned hemagglutinin DNA.
Cell 1983;33(2):435-43.
1983: Michael Roth; R V Srinivas; Richard W Compans
Basolateral maturation of retroviruses in polarized epithelial cells.
Journal of virology 1983;45(3):1065-73.
1981: Michael Roth; Richard W Compans
Delayed appearance of pseudotypes between vesicular stomatitis virus influenza virus during mixed infection of MDCK cells.
Journal of virology 1981;40(3):848-60.
1980: Michael Roth; Richard W Compans
Antibody-resistant spread of vesicular stomatitis virus infection in cell lines of epithelial origin.
Journal of virology 1980;35(2):547-50.
1979: Michael Roth; J P Fitzpatrick; Richard W Compans
Polarity of influenza and vesicular stomatitis virus maturation in MDCK cells: lack of a requirement for glycosylation of viral glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(12):6430-4.