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Robert Jordan
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Network (preview)
12
Hruby, Dennis
6
Block, Timothy
4
MCMACKEN, ROGER
4
Bolken, Tove'
4
Dwek, Raymond
4
Mehta, Anand
3
Collett, Marc
3
Byrd, Chelsea
3
Pevear, Daniel
3
Yang, Guang
3
Schaffer, Priscilla
2
Duraffour, Sophie
2
Mucker, Eric
2
Wang, Lijuan
2
Grosenbach, Douglas
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Geonetwork of Robert Jordan (preview)
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All Publications
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2010: Jordan Robert; Chinsangaram Jarasvech; Bolken Tove' C; Tyavanagimatt Shanthakumar R; Tien Deborah; Jones Kevin F; Frimm Annie; Corrado Michael L; Pickens Margaret; Landis Patrick; Clarke Jean; Marbury Thomas C; Hruby Dennis E
Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.
Antimicrobial agents and chemotherapy 2010;54(6):2560-6.
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2009: Berhanu Aklile; King David S; Mosier Stacie; Jordan Robert; Jones Kevin F; Hruby Dennis E; Grosenbach Douglas W
ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.
Antimicrobial agents and chemotherapy 2009;53(12):4999-5009.
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2009: Huggins John; Goff Arthur; Hensley Lisa; Mucker Eric; Shamblin Josh; Wlazlowski Carly; Johnson Wendy; Chapman Jennifer; Larsen Tom; Twenhafel Nancy; Karem Kevin; Damon Inger K; Byrd Chelsea M; Bolken Tove' C; Jordan Robert; Hruby Dennis
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.
Antimicrobial agents and chemotherapy 2009;53(6):2620-5.
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2009: Jordan Robert; Goff Arthur; Frimm Annie; Corrado Michael L; Hensley Lisa E; Byrd Chelsea M; Mucker Eric; Shamblin Josh; Bolken Tove' C; Wlazlowski Carly; Johnson Wendy; Chapman Jennifer; Twenhafel Nancy; Tyavanagimatt Shanthakumar; Amantana Adams; Chinsangaram Jarasvech; Hruby Dennis E; Huggins John
ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
Antimicrobial agents and chemotherapy 2009;53(5):1817-22.
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2009: Smith Scott K; Olson Victoria A; Karem Kevin L; Jordan Robert; Hruby Dennis E; Damon Inger K
In vitro efficacy of ST246 against smallpox and monkeypox.
Antimicrobial agents and chemotherapy 2009;53(3):1007-12.
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2009: Chen Yali; Honeychurch Kady M; Yang Guang; Byrd Chelsea M; Harver Chris; Hruby Dennis E; Jordan Robert
Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis.
Virology journal 2009;6():44.
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2008: Nalca Aysegul; Hatkin Josh M; Garza Nicole L; Nichols Donald K; Norris Sarah W; Hruby Dennis E; Jordan Robert
Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model.
Antiviral research 2008;79(2):121-7.
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2008: Vora Surabhi; Damon Inger; Fulginiti Vincent; Weber Stephen G; Kahana Madelyn; Stein Sarah L; Gerber Susan I; Garcia-Houchins Sylvia; Lederman Edith; Hruby Dennis; Collins Limone; Scott Dorothy; Thompson Kenneth; Barson John V; Regnery Russell; Hughes Christine; Daum Robert S; Li Yu; Zhao Hui; Smith Scott; Braden Zach; Karem Kevin; Olson Victoria; Davidson Whitni; Trindade Giliane; Bolken Tove; Jordan Robert; Tien Debbie; Marcinak John
Severe eczema vaccinatum in a household contact of a smallpox vaccinee.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(10):1555-61.
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2008: Jordan Robert; Tien Deborah; Bolken Tove' C; Jones Kevin F; Tyavanagimatt Shanthakumar R; Strasser Josef; Frimm Annie; Corrado Michael L; Strome Phoebe G; Hruby Dennis E
Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor.
Antimicrobial agents and chemotherapy 2008;52(5):1721-7.
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2008: Grosenbach Douglas W; Jordan Robert; King David S; Berhanu Aklile; Warren Travis K; Kirkwood-Watts Dana L; Tyavanagimatt Shanthakumar; Tan Ying; Wilson Rebecca L; Jones Kevin F; Hruby Dennis E
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination.
Vaccine 2008;26(7):933-46.
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2008: Duraffour Sophie; Vigne Solenne; Vermeire Kurt; Garcel Aude; Vanstreels Els; Daelemans Dirk; Yang Guang; Jordan Robert; Hruby Dennis E; Crance Jean-Marc; Garin Daniel; Andrei Graciela; Snoeck Robert
Specific targeting of the F13L protein by ST-246 affects orthopoxvirus production differently.
Antiviral therapy 2008;13(8):977-90.
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2007: Quenelle Debra C; Prichard Mark N; Keith Kathy A; Hruby Dennis E; Jordan Robert; Painter George R; Robertson Alice; Kern Earl R
Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.
Antimicrobial agents and chemotherapy 2007;51(11):4118-24.
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2007: Katritch Vsevolod; Byrd Chelsea M; Tseitin Vladimir; Dai Dongcheng; Raush Eugene; Totrov Maxim; Abagyan Ruben; Jordan Robert; Hruby Dennis E
Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches.
Journal of computer-aided molecular design 2007;21(10-11):549-58.
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2007: Honeychurch Kady M; Yang Guang; Jordan Robert; Hruby Dennis E
The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus.
Journal of virology 2007;81(13):7310-5.
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2007: Sbrana Elena; Jordan Robert; Hruby Dennis E; Mateo Rosa I; Xiao Shu-Yuan; Siirin Marina; Newman Patrick C; DA Rosa Amelia P A Travassos; Tesh Robert B
Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.
The American journal of tropical medicine and hygiene 2007;76(4):768-73.
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2007: Bailey Thomas R; Rippin Susan R; Opsitnick Elizabeth; Burns Christopher J; Pevear Daniel C; Collett Marc S; Rhodes Gerry; Tohan Sanjeev; Huggins John W; Baker Robert O; Kern Earl R; Keith Kathy A; Dai Dongcheng; Yang Guang; Hruby Dennis; Jordan Robert
N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors.
Journal of medicinal chemistry 2007;50(7):1442-4.
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2007: Quenelle Debra C; Buller R M L; Parker Scott; Keith Kathy A; Hruby Dennis E; Jordan Robert; Kern Earl R
Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice.
Antimicrobial agents and chemotherapy 2007;51(2):689-95.
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2007: Duraffour Sophie; Snoeck Robert; de Vos Rita; van Den Oord Joost J; Crance Jean-Marc; Garin Daniel; Hruby Dennis E; Jordan Robert; De Clercq Erik; Andrei Graciela
Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures.
Antiviral therapy 2007;12(8):1205-16.
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2006: Jordan Robert; Hruby Dennis
Smallpox antiviral drug development: satisfying the animal efficacy rule.
Expert review of anti-infective therapy 2006;4(2):277-89.
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2005: Yang Guang; Pevear Daniel C; Davies Marc H; Collett Marc S; Bailey Tom; Rippen Susan; Barone Linda; Burns Chris; Rhodes Gerry; Tohan Sanjeev; Huggins John W; Baker Robert O; Buller R L Mark; Touchette Erin; Waller Kem; Schriewer Jill; Neyts Johan; DeClercq Erik; Jones Kevin; Hruby Dennis; Jordan Robert
An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge.
Journal of virology 2005;79(20):13139-49.
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2004: Yang Guang; Pevear Daniel C; Collett Marc S; Chunduru Srinivas; Young Dorothy C; Benetatos Christopher; Jordan Robert
Newly synthesized hepatitis C virus replicon RNA is protected from nuclease activity by a protease-sensitive factor(s).
Journal of virology 2004;78(18):10202-5.
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2002: Jordan Robert; Wang Lijuan; Graczyk Thomas M; Block Timothy M; Romano Patrick R
Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells.
Journal of virology 2002;76(19):9588-99.
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2002: Mehta Anand; Ouzounov Serguey; Jordan Robert; Simsek Ender; Lu Xuanyong; Moriarty Robert M; Jacob Gary; Dwek Raymond A; Block Timothy M
Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ.
Antiviral chemistry & chemotherapy 2002;13(5):299-304.
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2002: Ouzounov Serguey; Mehta Anand; Dwek Raymond A; Block Timothy M; Jordan Robert
The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy.
Antiviral research 2002;55(3):425-35.
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2002: Jordan Robert; Nikolaeva Olga V; Wang Lijuan; Conyers Bertha; Mehta Anand; Dwek Raymond A; Block Timothy M
Inhibition of host ER glucosidase activity prevents Golgi processing of virion-associated bovine viral diarrhea virus E2 glycoproteins and reduces infectivity of secreted virions.
Virology 2002;295(1):10-9.
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2001: Block T M; Jordan R
Iminosugars as possible broad spectrum anti hepatitis virus agents: the glucovirs and alkovirs.
Antiviral chemistry & chemotherapy 2001;12(6):317-25.
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2001: Mehta A; Carrouée S; Conyers B; Jordan R; Butters T; Dwek R A; Block T M
Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications.
Hepatology (Baltimore, Md.) 2001;33(6):1488-95.
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1999: Jordan R; Schang L; Schaffer P A
Transactivation of herpes simplex virus type 1 immediate-early gene expression by virion-associated factors is blocked by an inhibitor of cyclin-dependent protein kinases.
Journal of virology 1999;73(10):8843-7.
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1998: Jordan R; Pepe J; Schaffer P A
Characterization of a nerve growth factor-inducible cellular activity that enhances herpes simplex virus type 1 gene expression and replication of an ICP0 null mutant in cells of neural lineage.
Journal of virology 1998;72(7):5373-82.
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1998: Russell R; Jordan R; McMacken R
Kinetic characterization of the ATPase cycle of the DnaK molecular chaperone.
Biochemistry 1998;37(2):596-607.
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1997: Jordan R; Schaffer P A
Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis.
Journal of virology 1997;71(9):6850-62.
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1995: Jordan R; McMacken R
Modulation of the ATPase activity of the molecular chaperone DnaK by peptides and the DnaJ and GrpE heat shock proteins.
The Journal of biological chemistry 1995;270(9):4563-9.
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1993: Montgomery D; Jordan R; McMacken R; Freire E
Thermodynamic and structural analysis of the folding/unfolding transitions of the Escherichia coli molecular chaperone DnaK.
Journal of molecular biology 1993;232(2):680-92.
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1992: Landry S J; Jordan R; McMacken R; Gierasch L M
Different conformations for the same polypeptide bound to chaperones DnaK and GroEL.
Nature 1992;355(6359):455-7.
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