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veronica Novotny-diermayr

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Stefan Hart; Ramesh Jayaraman; Babita Madan; Ultan McDermott; Nurulhuda Mustafa; Harish Nagaraj; Bee Kheng Ng; veronica Novotny-diermayr; Lai Chun Ong; Khalid M Pasha; Yong Cheng Tan; Meredith Williams; Chithra Amalini; Cyril Benes; Albert Cheong; Wee Joo Chng; Brian Dymock; Kantharaj Ethirajulu; Mathew Garnett; Boon Cher Goh; Kee Chuan Goh; Jeanette M Wood
VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
veronica Novotny-diermayr; L-C Ong; M K Pasha; A Cheong; K Ethirajulu; K C Goh; Stefan Hart; H Hentze; R Jayaraman; J M Wood
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.
K C Goh; Stefan Hart; C Hu; R Jayaraman; Y K Loh; veronica Novotny-diermayr; K H Ong; L C Ong; E T Sun; Y C Tan; A D William; F Burrows; A Cheong; B W Dymock; K Ethirajulu; J M Wood
TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties.

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2013: Stefan Hart; Ramesh Jayaraman; Babita Madan; Ultan McDermott; Nurulhuda Mustafa; Harish Nagaraj; Bee Kheng Ng; veronica Novotny-diermayr; Lai Chun Ong; Khalid M Pasha; Yong Cheng Tan; Meredith Williams; Chithra Amalini; Cyril Benes; Albert Cheong; Wee Joo Chng; Brian Dymock; Kantharaj Ethirajulu; Mathew Garnett; Boon Cher Goh; Kee Chuan Goh; Jeanette M Wood
VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
Molecular cancer therapeutics 2013;12(2):151-61.
2012: veronica Novotny-diermayr; L-C Ong; M K Pasha; A Cheong; K Ethirajulu; K C Goh; Stefan Hart; H Hentze; R Jayaraman; J M Wood
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.
Blood cancer journal 2012;2(5):e69.
2012: K C Goh; Stefan Hart; C Hu; R Jayaraman; Y K Loh; veronica Novotny-diermayr; K H Ong; L C Ong; E T Sun; Y C Tan; A D William; F Burrows; A Cheong; B W Dymock; K Ethirajulu; J M Wood
TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties.
Leukemia 2012;26(2):236-43.
2011: Stefan Hart; B Kheng; B Madan; veronica Novotny-diermayr; L C Ong; Y C Tan; C Amalini; A Cheong; W J Chng; K C Goh; J Zhou; J M Wood
Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia.
Blood cancer journal 2011;1(11):e44.
2011: Stefan Hart; H Hentze; C Y Hu; R Jayaraman; A Lee; Y K Loh; B Madan; veronica Novotny-diermayr; K H Ong; L C Ong; A Poulsen; Y C Tan; A D William; C Amalini; B W Dymock; K Ethirajulu; K C Goh; J W Wood
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.
Leukemia 2011;25(11):1751-9.
2011: W P Yong; D Chan; K Ethirajulu; Boon Cher Goh; Soo-Chin Lee; D Lim; R Lim; veronica Novotny-diermayr; E Seah; Ross Soo; Han Chong Toh; J Wood; W L Yeo; J Zhu
Phase I and pharmacodynamic study of an orally administered novel inhibitor of histone deacetylases, SB939, in patients with refractory solid malignancies.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2011;22(11):2516-22.
2011: veronica Novotny-diermayr; Mohammed Khalid Pasha; Nina Sausgruber; Han Chong Toh; Kantharaj Ethirajulu; Boon Cher Goh; Hannes Hentze; Ramesh Jayaraman; Yung Kiang Loh; Wei-Peng Yong; Joy Zhu; Jeanette Marjorie Wood
Pharmacodynamic evaluation of the target efficacy of SB939, an oral HDAC inhibitor with selectivity for tumor tissue.
Molecular cancer therapeutics 2011;10(7):1207-17.
2011: A R A Razak; Sebastien J Hotte; Lillian L Siu; Eric X Chen; Hal Hirte; J Powers; W Walsh; L-A Stayner; A Laughlin; veronica Novotny-diermayr; J Zhu; Elizabeth A Eisenhauer
Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours.
British journal of cancer 2011;104(5):756-62.
2010: veronica Novotny-diermayr; Kanda Sangthongpitag; Chang Yong Hu; Xiaofeng Wu; Nina Sausgruber; Pauline Yeo; Gediminas Greicius; Sven Pettersson; Ai Leng Liang; Yung Kiang Loh; Zahid Bonday; Kee Chuan Goh; Hannes Hentze; Stefan Hart; Haishan Wang; Kantharaj Ethirajulu; Jeanette Marjorie Wood
SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.
Molecular cancer therapeutics 2010;9(3):642-52.
2005: veronica Novotny-diermayr; Baohong Lin; Lei Gu; Xinmin Cao
Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.
The Journal of biological chemistry 2005;280(13):12747-57.
2005: Aijun Hao; veronica Novotny-diermayr; Wei Bian; Baohong Lin; Cheh Peng Lim; Naihe Jing; Xinmin Cao
The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.
Molecular biology of the cell 2005;16(4):1569-83.
2003: Jing Ma; Tong Zhang; veronica Novotny-diermayr; Agnes L C Tan; Xinmin Cao
A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation.
The Journal of biological chemistry 2003;278(31):29252-60.
2003: Chengchen Lufei; Jing Ma; Guochang Huang; Tong Zhang; veronica Novotny-diermayr; Chin Thing Ong; Xinmin Cao
GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.
The EMBO journal 2003;22(6):1325-35.
2002: veronica Novotny-diermayr; Tong Zhang; Lei Gu; Xinmin Cao
Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction.
The Journal of biological chemistry 2002;277(51):49134-42.
2002: Christos Diakos; Eva E Prieschl; Marcus D Saemann; veronica Novotny-diermayr; Georg Bohmig; Robert Csonga; Thomas Baumruker; Gerhard J Zlabinger
Novel mode of interference with nuclear factor of activated T-cells regulation in T-cells by the bacterial metabolite n-butyrate.
The Journal of biological chemistry 2002;277(27):24243-51.
2000: Eva E Prieschl; Robert Csonga; veronica Novotny-diermayr; G E Kikuchi; Thomas Baumruker
Glycosphingolipid-induced relocation of Lyn and Syk into detergent-resistant membranes results in mast cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5389-97.
1999: Eva E Prieschl; Robert Csonga; veronica Novotny-diermayr; G E Kikuchi; Thomas Baumruker
The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering.
The Journal of experimental medicine 1999;190(1):1-8.
1999: Thomas Baumruker; Robert Csonga; D Jaksche; veronica Novotny-diermayr; Eva E Prieschl
TNF-alpha and IL-5 gene induction in IgE plus antigen-stimulated mast cells require common and distinct signaling pathways.
International archives of allergy and immunology 1999;118(2-4):108-11.
1998: veronica Novotny-diermayr; Eva E Prieschl; Robert Csonga; G Fabjani; Thomas Baumruker
Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells.
Nucleic acids research 1998;26(23):5480-5.
1998: Eva E Prieschl; veronica Novotny-diermayr; Robert Csonga; D Jaksche; Adelheid Elbe-Bürger; W Thumb; M Auer; Georg Stingl; Thomas Baumruker
A novel splice variant of the transcription factor Nrf1 interacts with the TNFalpha promoter and stimulates transcription.
Nucleic acids research 1998;26(10):2291-7.
1998: Robert Csonga; Eva E Prieschl; D Jaksche; veronica Novotny-diermayr; Thomas Baumruker
Common and distinct signaling pathways mediate the induction of TNF-alpha and IL-5 in IgE plus antigen-stimulated mast cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):273-83.