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hugo vanderstichele

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D Richard Lachno; Margaret M Racke; Michael Robertson; Jayne A Talbot; hugo vanderstichele; Ronald B DeMattos; Barbara A Evert; Robert J Konrad; Robert A Dean
Validation of assays for measurement of amyloid-β peptides in cerebrospinal fluid and plasma specimens from patients with Alzheimer's disease treated with solanezumab.
Nathalie Le Bastard; Jean-Jacques Martin; hugo vanderstichele; Eugeen Vanmechelen; Els Coart; Sebastiaan Engelborghs
Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia.
Niklas Mattsson; Kevin Mills; Josef Pannee; Marianne Ratcliffe; Leslie M Shaw; Adam J Simon; Holly Soares; Charlotte E Teunissen; Robert M Umek; hugo vanderstichele; Marcel M Verbeek; Ingrid Zegers; Henrik Zetterberg; Ulf Andreasson; Maria Bjerke; Marinus A Blankenstein; Kaj Blennow; Robert Bowser; Maria C Carrillo; Johan Gobom; Theresa Heath; Rand Jenkins; Andreas Jeromin; June Kaplow; Daniel Kidd; Omar F Laterza; Andrew Lockhart; Michael P Lunn; Robert L Martone; Erik Portelius
Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.

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2013: D Richard Lachno; Margaret M Racke; Michael Robertson; Jayne A Talbot; hugo vanderstichele; Ronald B DeMattos; Barbara A Evert; Robert J Konrad; Robert A Dean
Validation of assays for measurement of amyloid-β peptides in cerebrospinal fluid and plasma specimens from patients with Alzheimer's disease treated with solanezumab.
Journal of Alzheimer's disease : JAD 2013;34(4):897-910.
2013: Nathalie Le Bastard; Jean-Jacques Martin; hugo vanderstichele; Eugeen Vanmechelen; Els Coart; Sebastiaan Engelborghs
Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia.
Journal of Alzheimer's disease : JAD 2013;33(1):117-31.
2012: Niklas Mattsson; Kevin Mills; Josef Pannee; Marianne Ratcliffe; Leslie M Shaw; Adam J Simon; Holly Soares; Charlotte E Teunissen; Robert M Umek; hugo vanderstichele; Marcel M Verbeek; Ingrid Zegers; Henrik Zetterberg; Ulf Andreasson; Maria Bjerke; Marinus A Blankenstein; Kaj Blennow; Robert Bowser; Maria C Carrillo; Johan Gobom; Theresa Heath; Rand Jenkins; Andreas Jeromin; June Kaplow; Daniel Kidd; Omar F Laterza; Andrew Lockhart; Michael P Lunn; Robert L Martone; Erik Portelius
Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.
Biomarkers in medicine 2012;6(4):409-17.
2012: Ulf Andreasson; Leslie M Shaw; Eugeen Vanmechelen; Henrik Zetterberg; hugo vanderstichele
Analytical aspects of molecular Alzheimer's disease biomarkers.
Biomarkers in medicine 2012;6(4):377-89.
2012: Michal J Figurski; Magdalena Korecka; Virginia M-Y Lee; Leslie M Shaw; Jon Toledo; John Q Trojanowski; hugo vanderstichele; Teresa Waligórska
Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer's Disease Neuroimaging Initiative study patients.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(4):250-60.
2012: Ju-Hee Kang; John Q Trojanowski; hugo vanderstichele; Leslie M Shaw
Simultaneous analysis of cerebrospinal fluid biomarkers using microsphere-based xMAP multiplex technology for early detection of Alzheimer's disease.
Methods (San Diego, Calif.) 2012;56(4):484-93.
2012: Armand Perret-Liaudet; Isabelle Quadrio; Susanna Schraen; Yannick Tholance; Catherine Thomas-Anterion; Eric Thouvenot; Jacques Touchon; hugo vanderstichele; Willy Zorzi; Arnaud Coudreuse; Benoit Dumont; Benaissa ElMoualij; Audrey Gabelle; Gabor Geza Kovacs; Pierre Krolak-Salmon; Olivier Moreaud; Mathieu Pelpel; Sylvain Lehmann
Cerebrospinal fluid collection tubes: a critical issue for Alzheimer disease diagnosis.
Clinical chemistry 2012;58(4):787-9.
2012: D Richard Lachno; Stephen L Lowe; Ferenc Martényi; Paul E Oefinger; Jayne A Talbot; hugo vanderstichele; Julie K Emerson; Celedon Gonzales; Robert J Konrad; Robert A Dean
Validation of a multiplex assay for simultaneous quantification of amyloid-β peptide species in human plasma with utility for measurements in studies of Alzheimer's disease therapeutics.
Journal of Alzheimer's disease : JAD 2012;32(4):905-18.
2012: Armand Perret-Liaudet; Isabelle Quadrio; Susanna Schraen; Yannick Tholance; Catherine Thomas-Anterion; Eric Thouvenot; Jacques Touchon; hugo vanderstichele; Willy Zorzi; Arnaud Coudreuse; Benoit Dumont; Benaissa Elmoualij; Audrey Gabelle; Gabor Geza Kovacs; Pierre Krolak-Salmon; Olivier Moreaud; Mathieu Pelpel; Sylvain Lehmann
Risk of Alzheimer's disease biological misdiagnosis linked to cerebrospinal collection tubes.
Journal of Alzheimer's disease : JAD 2012;31(1):13-20.
2012: hugo vanderstichele; Dirk Wouters; Mirko Bibl; Sebastiaan Engelborghs; Nathalie Le Bastard; Piotr Lewczuk; Jose Luis Molinuevo; Lucilla Parnetti; Armand Perret-Liaudet; Leslie M Shaw; Charlotte Teunissen; Kaj Blennow
Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(1):65-73.
2011: Jon B Toledo; John Q Trojanowski; hugo vanderstichele; Michael W Weiner; Sharon X Xie; Paul S Aisen; Charles DeCarli; Michal Figurski; Clifford R Jack; William Jagust; Virginia M-Y Lee; Ronald C. Petersen; Leslie M Shaw; Arthur W Toga; Estefanía Toledo
Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI.
Acta neuropathologica 2011;122(4):401-13.
2011: Anne M Fagan; Els Coart; Mark A Mintun; John C Morris; Leslie M Shaw; John Q Trojanowski; hugo vanderstichele; Chengjie Xiong; David M Holtzman
Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology.
Archives of neurology 2011;68(9):1137-44.
2011: Leslie M Shaw; Eric Siemers; Adam J Simon; Holly Soares; John Q Trojanowski; hugo vanderstichele; Kaj Blennow; Els Coart; Robert A Dean; Michal Figurski; Malgorzata Knapik-Czajka; Virginia M-Y Lee; Piotr Lewczuk; William Potter
Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI.
Acta neuropathologica 2011;121(5):597-609.
2011: D Richard Lachno; Patrick C May; Martin J Romeo; Gopalan Sethuraman; Eric R Siemers; Jayne A Talbot; hugo vanderstichele; Joseph J Zajac; Els Coart; Ronald B DeMattos; Hans F Jensen; Robert J Konrad; Robert A Dean
Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies.
Journal of Alzheimer's disease : JAD 2011;26(3):531-41.
2010: Nathalie Le Bastard; Jean-Jacques Martin; Eugeen Vanmechelen; hugo vanderstichele; Peter Paul De Deyn; Sebastiaan Engelborghs
Added diagnostic value of CSF biomarkers in differential dementia diagnosis.
Neurobiology of aging 2010;31(11):1867-76.
2010: Geert De Meyer; Fred Shapiro; hugo vanderstichele; Eugeen Vanmechelen; Sebastiaan Engelborghs; Peter Paul De Deyn; Els Coart; Oskar Hansson; Lennart Minthon; Henrik Zetterberg; Kaj Blennow; Leslie Shaw; John Q Trojanowski
Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people.
Archives of neurology 2010;67(8):949-56.
2010: Oskar Hansson; Henrik Zetterberg; Eugeen Vanmechelen; hugo vanderstichele; Ulf Andreasson; Elisabet Londos; Anders Wallin; Lennart Minthon; Kaj Blennow
Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment.
Neurobiology of aging 2010;31(3):357-67.
2009: Leslie M Shaw; hugo vanderstichele; Malgorzata Knapik-Czajka; Christopher M Clark; Paul S Aisen; Ronald C. Petersen; Kaj Blennow; Holly Soares; Adam Simon; Piotr Lewczuk; Robert Dean; Eric Siemers; William Potter; Virginia M-Y Lee; John Q Trojanowski
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.
Annals of neurology 2009;65(4):403-13.
2009: D R Lachno; hugo vanderstichele; G De Groote; V Kostanjevecki; Geert De Meyer; E R Siemers; M B Willey; J S Bourdage; R J Konrad; R A Dean
The influence of matrix type, diurnal rhythm and sample collection and processing on the measurement of plasma beta-amyloid isoforms using the INNO-BIA plasma Abeta forms multiplex assay.
The journal of nutrition, health & aging 2009;13(3):220-5.
2009: Kaj Blennow; Geert De Meyer; Oskar Hansson; L Minthon; Anders Wallin; Henrik Zetterberg; P Lewczuk; hugo vanderstichele; E Vanmechelen; J Kornhuber; J Wiltfang; I Heuser; W Maier; C Luckhaus; E Rüther; M Hüll; H Jahn; H J Gertz; Lutz Froelich; Harald Hampel; R Pernetzki
Evolution of Abeta42 and Abeta40 levels and Abeta42/Abeta40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment.
The journal of nutrition, health & aging 2009;13(3):205-8.
2008: S M Chafekar; R Zwart; R Veerhuis; hugo vanderstichele; Frank Baas; Wiep Scheper
Increased Abeta1-42 production sensitizes neuroblastoma cells for ER stress toxicity.
Current Alzheimer research 2008;5(5):469-74.
2008: Sebastiaan Engelborghs; Karen De Vreese; Tom Van de Casteele; hugo vanderstichele; Bart Van Everbroeck; Patrick Cras; Jean-Jacques Martin; Eugeen Vanmechelen; Peter Paul De Deyn
Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia.
Neurobiology of aging 2008;29(8):1143-59.
2008: Judith M de Bont; hugo vanderstichele; Roel E Reddingius; Rob Pieters; Stefaan W Van Gool
Increased total-Tau levels in cerebrospinal fluid of pediatric hydrocephalus and brain tumor patients.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2008;12(4):334-41.
2008: Piotr Lewczuk; Johannes Kornhuber; hugo vanderstichele; Eugeen Vanmechelen; Hermann Esselmann; Mirko Bibl; Stefanie Wolf; Markus Otto; Udo Reulbach; Heike Kölsch; Frank Jessen; Johannes Schröder; Peter Schönknecht; Harald Hampel; Oliver Peters; Erik Weimer; Robert Perneczky; Holger Jahn; Christian Luckhaus; Ulrich Lamla; Tillmann Supprian; Juan Manuel Maler; Jens Wiltfang
Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study.
Neurobiology of aging 2008;29(6):812-8.
2007: Henrik Zetterberg; Mona Pedersen; Karin Lind; Maria Svensson; Sindre Rolstad; Carl Eckerström; Steinar Syversen; Ulla-Britt Mattsson; Christina Ysander; Niklas Mattsson; Arto Nordlund; hugo vanderstichele; Eugeen Vanmechelen; Michael Jonsson; Ake Edman; Kaj Blennow; Anders Wallin
Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years.
Journal of Alzheimer's disease : JAD 2007;12(3):255-60.
2006: Charlotte E Teunissen; Christine D Dijkstra; jasperse bas; Frederik Barkhof; hugo vanderstichele; Eugeen Vanmechelen; Chris H Polman; Lars Bö
Growth-associated protein 43 in lesions and cerebrospinal fluid in multiple sclerosis.
Neuropathology and applied neurobiology 2006;32(3):318-31.
2006: hugo vanderstichele; Karen De Vreese; Kaj Blennow; Niels Andreasen; C J M Sindic; Adrian Ivanoiu; Harald Hampel; Katharina Bürger; Lucilla Parnetti; Alessia Lanari; Alessandro Padovani; Monica DiLuca; Miriam Bläser; Annika Ohrfelt Olsson; Hans Pottel; Frank Hulstaert; Eugeen Vanmechelen
Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodies.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2006;44(12):1472-80.
2005: hugo vanderstichele; Geert De Meyer; Niels Andreasen; Vesna Kostanjevecki; Anders Wallin; Annika Olsson; Kaj Blennow; Eugeen Vanmechelen
Amino-truncated beta-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment.
Clinical chemistry 2005;51(9):1650-60.
2005: Niki S M Schoonenboom; Cees Mulder; hugo vanderstichele; Y A L Pijnenburg; Gerard J van Kamp; Philip scheltens; Pankaj D Mehta; Marinus A Blankenstein
Differences and similarities between two frequently used assays for amyloid beta 42 in cerebrospinal fluid.
Clinical chemistry 2005;51(6):1057-60.
2005: Annika Olsson; hugo vanderstichele; Niels Andreasen; Geert De Meyer; Anders Wallin; Björn Holmberg; Lars Rosengren; Eugeen Vanmechelen; Kaj Blennow
Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology.
Clinical chemistry 2005;51(2):336-45.
2005: Jens Wiltfang; Piotr Lewczuk; Peter Riederer; Edna Grünblatt; Christoph Hock; Philip scheltens; Harald Hampel; hugo vanderstichele; Khalid Iqbal; Douglas Galasko; Lars Lannfelt; Markus Otto; Hermann Esselmann; Andreas Wolfram Henkel; Johannes Kornhuber; Kaj Blennow
Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2005;6(2):69-84.
2005: K Hoglund; K M Thelen; Steinar Syversen; M Sjogren; K von Bergmann; Anders Wallin; Eugeen Vanmechelen; hugo vanderstichele; D Lutjohann; Kaj Blennow
The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease.
Dementia and geriatric cognitive disorders 2005;19(5-6):256-65.
2005: Niki S M Schoonenboom; Cees Mulder; hugo vanderstichele; Evert-Jan van Elk; astrid kok; Gerard J van Kamp; Philip scheltens; Marinus A Blankenstein
Effects of processing and storage conditions on amyloid beta (1-42) and tau concentrations in cerebrospinal fluid: implications for use in clinical practice.
Clinical chemistry 2005;51(1):189-95.
2004: Kina Höglund; Olov Wiklund; hugo vanderstichele; Oliver Eikenberg; Eugeen Vanmechelen; Kaj Blennow
Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins.
Archives of neurology 2004;61(3):333-7.
2004: Stefaan W Van Gool; Geert De Meyer; André Van de Voorde; Eugeen Vanmechelen; hugo vanderstichele
Neurotoxicity marker profiles in the CSF are not age-dependent but show variation in children treated for acute lymphoblastic leukemia.
Neurotoxicology 2004;25(3):471-80.
2004: Harald Hampel; Katharina Buerger; Raymond Zinkowski; Stefan J Teipel; Alexander Goernitz; Niels Andreasen; Magnus Sjoegren; John DeBernardis; Daniel Kerkman; Koichi Ishiguro; Hideto Ohno; Eugeen Vanmechelen; hugo vanderstichele; Cheryl McCulloch; Hans-Jurgen Moller; Peter Davies; Kaj Blennow
Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study.
Archives of general psychiatry 2004;61(1):95-102.
2003: Javier Sáez-Valero; Lisa R Fodero; M Sjögren; Niels Andreasen; Serena Amici; Virgilio Gallai; hugo vanderstichele; E Vanmechelen; Lucilla Parnetti; Kaj Blennow; David Small
Glycosylation of acetylcholinesterase and butyrylcholinesterase changes as a function of the duration of Alzheimer's disease.
Journal of neuroscience research 2003;72(4):520-6.
2003: Matthias Riemenschneider; Stefan Wagenpfeil; hugo vanderstichele; M Otto; J Wiltfang; Hans A Kretzschmar; Eugeen Vanmechelen; hans förstl; Alexander Kurz
Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias.
Molecular psychiatry 2003;8(3):343-7.
2003: Annika Olsson; Eugeen Vanmechelen; hugo vanderstichele; Pia Davidsson; Kaj Blennow
Unaltered plasma levels of beta-amyloid(1-40) and beta-amyloid(1-42) upon stimulation of human platelets.
Dementia and geriatric cognitive disorders 2003;16(2):93-7.
2003: Niels Andreasen; Eugeen Vanmechelen; hugo vanderstichele; Pia Davidsson; Kaj Blennow
Cerebrospinal fluid levels of total-tau, phospho-tau and A beta 42 predicts development of Alzheimer's disease in patients with mild cognitive impairment.
Acta neurologica Scandinavica. Supplementum 2003;179():47-51.
2003: Ingmar Skoog; Pia Davidsson; O Aevarsson; hugo vanderstichele; Eugeen Vanmechelen; Kaj Blennow
Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population-based study in 85-year-olds.
Dementia and geriatric cognitive disorders 2003;15(3):169-76.
2002: Bart Van Everbroeck; A J E Green; Eugeen Vanmechelen; hugo vanderstichele; Philippe Pals; R Sanchez-Valle; N Cuadrado Corrales; Jean-Jacques Martin; Patrick Cras
Phosphorylated tau in cerebrospinal fluid as a marker for Creutzfeldt-Jakob disease.
Journal of neurology, neurosurgery, and psychiatry 2002;73(1):79-81.
2002: Matthias Riemenschneider; M Schmolke; Nicola T Lautenschlager; hugo vanderstichele; E Vanmechelen; WG Guder; Alexander Kurz
Association of CSF apolipoprotein E, Abeta42 and cognition in Alzheimer's disease.
Neurobiology of aging 2002;23(2):205-11.
2001: Eugeen Vanmechelen; hugo vanderstichele; Frank Hulstaert; Niels Andreasen; L Minthon; Bengt Winblad; P Davidsson; Kaj Blennow
Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders.
Mechanisms of ageing and development 2001;122(16):2005-11.
2001: M Sjögren; hugo vanderstichele; Hans Agren; Olof Zachrisson; Mikael Edsbagge; Carsten Wikkelsø; Ingmar Skoog; Anders Wallin; Lars-Olof Wahlund; J Marcusson; Katarina Nägga; Niels Andreasen; P Davidsson; Eugeen Vanmechelen; Kaj Blennow
Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values.
Clinical chemistry 2001;47(10):1776-81.
2001: Niels Andreasen; Johan Gottfries; Eugeen Vanmechelen; hugo vanderstichele; P Davidson; Kaj Blennow; L Rosengren; K Blennow
Evaluation of CSF biomarkers for axonal and neuronal degeneration, gliosis, and beta-amyloid metabolism in Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2001;71(4):557-8.
2001: P Cupers; Mostafa Bentahir; Katleen Craessaerts; IC Orlans; hugo vanderstichele; Paul Saftig; Bart De Strooper; Willem ANNAERT
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
The Journal of cell biology 2001;154(4):731-40.
2001: Magnus Sjögren; Pia Davidsson; Johan Gottfries; hugo vanderstichele; Ake Edman; Eugeen Vanmechelen; Anders Wallin; Kaj Blennow
The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process.
Dementia and geriatric cognitive disorders 2001;12(4):257-64.
2001: K Hemmer; L Fransen; hugo vanderstichele; E Vanmechelen; Paul Heuschling
An in vitro model for the study of microglia-induced neurodegeneration: involvement of nitric oxide and tumor necrosis factor-alpha.
Neurochemistry international 2001;38(7):557-65.
2001: Magnus Sjögren; Pia Davidsson; Mats Tullberg; Lennart Minthon; Anders Wallin; Carsten Wikkelso; Ann-Kathrine Granérus; hugo vanderstichele; Eugeen Vanmechelen; Kaj Blennow
Both total and phosphorylated tau are increased in Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2001;70(5):624-30.
2001: Niels Andreasen; Lennart Minthon; Pia Davidsson; Eugeen Vanmechelen; hugo vanderstichele; Bengt Winblad; Kaj Blennow
Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice.
Archives of neurology 2001;58(3):373-9.
2001: C Hesse; L Rosengren; Niels Andreasen; Pia Davidsson; hugo vanderstichele; Eugeen Vanmechelen; Kaj Blennow
Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke.
Neuroscience letters 2001;297(3):187-90.
2000: Stefaan W Van Gool; E Van Kerschaver; P Brock; Hans Pottel; Frank Hulstaert; Eugeen Vanmechelen; Anne Uyttebroeck; André Van de Voorde; hugo vanderstichele
Disease- and treatment-related elevation of the neurodegenerative marker tau in children with hematological malignancies.
Leukemia 2000;14(12):2076-84.
2000: hugo vanderstichele; E Van Kerschaver; C Hesse; Pia Davidsson; M A Buyse; Niels Andreasen; L Minthon; Anders Wallin; Kaj Blennow; Eugeen Vanmechelen
Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(4):245-58.
2000: C Hesse; L Rosengren; Eugeen Vanmechelen; hugo vanderstichele; C Jensen; Pia Davidsson; Kaj Blennow
Cerebrospinal fluid markers for Alzheimer's disease evaluated after acute ischemic stroke.
Journal of Alzheimer's disease : JAD 2000;2(3-4):199-206.
2000: Samir Kumar-Singh; Chris De Jonghe; Marc Cruts; R Kleinert; Rong Wang; Marc Mercken; Bart De Strooper; hugo vanderstichele; Ann Löfgren; I Vanderhoeven; Hubert Backhovens; Eugeen Vanmechelen; P M Kroisel; Christine Van Broeckhoven
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
Human molecular genetics 2000;9(18):2589-98.
2000: Jo Van Dorpe; Liesbet Smeijers; Ilse Dewachter; Dieter Nuyens; Kurt Spittaels; Chris Van den Haute; Marc Mercken; Dieder Moechars; I Laenen; Cuno Kuiperi; K Bruynseels; Ina C. Tesseur; R Loos; hugo vanderstichele; F Checler; Raf Sciot; Fred Van Leuven
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.
The American journal of pathology 2000;157(4):1283-98.
2000: Ilse Dewachter; Jo Van Dorpe; Liesbet Smeijers; M Gilis; Cuno Kuipéri; I Laenen; Nathalie Caluwaerts; Dieder Moechars; F Checler; hugo vanderstichele; Fred Van Leuven
Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6452-8.
2000: Eugeen Vanmechelen; hugo vanderstichele; Pia Davidsson; E Van Kerschaver; B Van Der Perre; M Sjögren; Niels Andreasen; Kaj Blennow
Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization.
Neuroscience letters 2000;285(1):49-52.
2000: Matthias Riemenschneider; M Schmolke; Nicola T Lautenschlager; WG Guder; hugo vanderstichele; Eugeen Vanmechelen; Alexander Kurz
Cerebrospinal beta-amyloid ((1-42)) in early Alzheimer's disease: association with apolipoprotein E genotype and cognitive decline.
Neuroscience letters 2000;284(1-2):85-8.
2000: M Sjögren; Lennart Minthon; Pia Davidsson; A Clarberg; hugo vanderstichele; Eugeen Vanmechelen; Anders Wallin; Kaj Blennow
CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging.
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(5):563-79.
1999: Niels Andreasen; Lennart Minthon; A Clarberg; Pia Davidsson; Johan Gottfries; Eugeen Vanmechelen; hugo vanderstichele; Bengt Winblad; Kaj Blennow
Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample.
Neurology 1999;53(7):1488-94.
1999: An Herreman; Dieter Hartmann; Willem ANNAERT; Paul Saftig; Katleen Craessaerts; Lutgarde Serneels; Lieve Umans; V Schrijvers; F Checler; hugo vanderstichele; Veerle Baekelandt; R Dressel; P Cupers; Danny Huylebroeck; An Zwijsen; Fred Van Leuven; Bart De Strooper
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11872-7.
1999: Niels Andreasen; Lennart Minthon; Eugeen Vanmechelen; hugo vanderstichele; Pia Davidsson; Bengt Winblad; Kaj Blennow
Cerebrospinal fluid tau and Abeta42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment.
Neuroscience letters 1999;273(1):5-8.
1999: Chris De Jonghe; Patrick Cras; hugo vanderstichele; Marc Cruts; I Vanderhoeven; Iris Smouts; Eugeen Vanmechelen; Jean-Jacques Martin; L Hendriks; Christine Van Broeckhoven
Evidence that Abeta42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phenotype.
Neurobiology of disease 1999;6(4):280-7.
1999: Chris De Jonghe; Marc Cruts; Ekaterina Rogaeva; C Tysoe; Andrew Singleton; hugo vanderstichele; W Meschino; Bart Dermaut; I Vanderhoeven; Hubert Backhovens; Eugeen Vanmechelen; Christopher M Morris; John Hardy; David C Rubinsztein; Peter St George-Hyslop; Christine Van Broeckhoven
Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.
Human molecular genetics 1999;8(8):1529-40.
1999: Niels Andreasen; C Hesse; Pia Davidsson; Lennart Minthon; Anders Wallin; Bengt Winblad; hugo vanderstichele; Eugeen Vanmechelen; Kaj Blennow
Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.
Archives of neurology 1999;56(6):673-80.
1999: Frank Hulstaert; Kaj Blennow; Adrian Ivanoiu; H C Schoonderwaldt; Matthias Riemenschneider; P P De Deyn; C Bancher; Patrick cras; J Wiltfang; Pankaj D Mehta; Khalid Iqbal; Hans Pottel; Eugeen Vanmechelen; hugo vanderstichele
Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF.
Neurology 1999;52(8):1555-62.
1999: Bart Dermaut; Marc Cruts; A J C Slooter; S Van Gestel; Chris De Jonghe; hugo vanderstichele; Eugeen Vanmechelen; Monique Breteler; Albert Hofman; C.M. Duijn; Christine Van Broeckhoven
The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease.
American journal of human genetics 1999;64(1):290-2.
1998: E Vanmechelen; hugo vanderstichele
Towards an earlier diagnosis of Alzheimer's disease.
Journal of biotechnology 1998;66(2-3):229-31.
1998: Johan Smitz; Rita Cortvrindt; Y Hu; hugo vanderstichele
Effects of recombinant activin A on in vitro culture of mouse preantral follicles.
Molecular reproduction and development 1998;50(3):294-304.
1998: Bart De Strooper; Paul Saftig; Katleen Craessaerts; hugo vanderstichele; G Guhde; Willem ANNAERT; Kurt von Figura; Fred Van Leuven
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
Nature 1998;391(6665):387-90.
1997: K Schotanus; WJ Hage; hugo vanderstichele; Robert van den Hurk
Effects of conditioned media from murine granulosa cell lines on the growth of isolated bovine preantral follicles.
Theriogenology 1997;48(3):471-83.
1997: S C Hulshof; José R Figueiredo; J F Beckers; M M Bevers; hugo vanderstichele; Robert van den Hurk
Bovine preantral follicles and activin: immunohistochemistry for activin and activin receptor and the effect of bovine activin A in vitro.
Theriogenology 1997;48(1):133-42.
1996: Fariborz Izadyar; E Zeinstra; Ben Colenbrander; hugo vanderstichele; Mart M Bevers
In vitro maturation of bovine oocytes in the presence of bovine activin A does not affect the number of embryos.
Animal reproduction science 1996;45(1-2):37-45.
1995: E Hoeben; T Briers; hugo vanderstichele; W De Smet; Walter Heyns; L Deboel; F Vanderhoydonck; Guido Verhoeven
Characterization of newly established testicular peritubular and prostatic stromal cell lines: potential use in the study of mesenchymal-epithelial interactions.
Endocrinology 1995;136(7):2862-73.
1994: J P de Winter; hugo vanderstichele; G Verhoeven; M A Timmerman; J G Wesseling; Frank de Jong
Peritubular myoid cells from immature rat testes secrete activin-A and express activin receptor type II in vitro.
Endocrinology 1994;135(2):759-67.
1994: hugo vanderstichele; Bernard Delaey; J de Winter; F de Jong; L Rombauts; Guido Verhoeven; C Dello; A van de Voorde; T Briers
Secretion of steroids, growth factors, and cytokines by immortalized mouse granulosa cell lines.
Biology of reproduction 1994;50(5):1190-202.
1994: H T Van Tol; F A de Loos; hugo vanderstichele; M M Bevers
Bovine activin A does not affect the in vitro maturation of bovine oocytes.
Theriogenology 1994;41(3):673-9.
1993: T W Briers; A van de Voorde; hugo vanderstichele
Characterization of immortalized mouse granulosa cell lines.
In vitro cellular & developmental biology. Animal 1993;29A(11):847-54.
1993: J P de Winter; hugo vanderstichele; M A Timmerman; Leen J Blok; Axel P N Themmen; Frank de Jong
Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function.
Endocrinology 1993;132(3):975-82.
1992: J P de Winter; M A Timmerman; hugo vanderstichele; I A Klaij; A J Grootenhuis; F F Rommerts; Frank de Jong
Testicular Leydig cells in vitro secrete only inhibin alpha-subunits, whereas Leydig cell tumors can secrete bioactive inhibin.
Molecular and cellular endocrinology 1992;83(2-3):105-15.
1990: hugo vanderstichele; W Eechaute; E Lacroix
Regulation of the pituitary 5 alpha-reductase activity by gonadotropin releasing hormone and testosterone in the adult male rat.
Journal of steroid biochemistry 1990;35(5):575-81.
1989: hugo vanderstichele; W Eechaute; E Lacroix; I Leusen
Effect of tamoxifen on the activity of enzymes of testicular steroidogenesis.
Steroids 1989;53(6):713-26.
1987: hugo vanderstichele; W Eechaute; E Lacroix; I Leusen
Influence of neonatal androgenization on the testicular steroidogenesis in the adult rat.
Journal of steroid biochemistry 1987;28(4):421-7.
1987: E Lacroix; W Eechaute; hugo vanderstichele; I Leusen
Influence of a prolonged tamoxifen administration on steroidogenesis by incubated rat testes.
Journal of steroid biochemistry 1987;28(3):301-5.
1987: Johan Van de Voorde; hugo vanderstichele; I Leusen
Release of endothelium-derived relaxing factor from human umbilical vessels.
Circulation research 1987;60(4):517-22.
1987: hugo vanderstichele; W Eechaute; E Lacroix; I Leusen
The effects of neonatal androgenization of male rats on testosterone metabolism by the hypothalamus-pituitary-gonadal axis.
Journal of steroid biochemistry 1987;26(4):493-7.