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Arto Urtti
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17
Järvinen, Tomi
15
Ruponen, Marika
14
Honkakoski, Paavo
14
Järvinen, Kristiina
14
Mönkkönen, Jukka
13
Jääskeläinen, Ilpo
13
Ranta, Veli-Pekka
12
Yliperttula, Marjo
12
Auriola, Seppo
11
Rönkkö, Seppo
9
Paronen, Petteri
9
Kontturi, Kyösti
7
Kirjavainen, Merja
7
Tammi, Markku
7
Toropainen, Elisa
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All Publications
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2009: Egorova Anna; Kiselev Anton; Hakli Marika; Ruponen Marika; Baranov Vladislav; Urtti Arto
Chemokine-derived peptides as carriers for gene delivery to CXCR4 expressing cells.
The journal of gene medicine 2009;11(9):772-81.
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2009: Mannermaa Eliisa; Vellonen Kati-Sisko; Ryhänen Tuomas; Kokkonen Katriina; Ranta Veli-Pekka; Kaarniranta Kai; Urtti Arto
Efflux protein expression in human retinal pigment epithelium cell lines.
Pharmaceutical research 2009;26(7):1785-91.
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2009: Ruponen Marika; Arkko Satu; Urtti Arto; Reinisalo Mika; Ranta Veli-Pekka
Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection.
Journal of controlled release : official journal of the Controlled Release Society 2009;136(3):226-31.
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2009: Huhtala Anne; Rönkkö Seppo; Teräsvirta Markku; Puustjärvi Tuomo; Sihvola Roope; Vehanen Katja; Laukkanen Antti; Anttila Johanna; Urtti Arto; Pohjonen Timo; Uusitalo Hannu
The effects of 5-fluorouracil on ocular tissues in vitro and in vivo after controlled release from a multifunctional implant.
Investigative ophthalmology & visual science 2009;50(5):2216-23.
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2008: Karskela Marika; Virta Pasi; Malinen Melina; Urtti Arto; Lönnberg Harri
Synthesis and cellular uptake of fluorescently labeled multivalent hyaluronan disaccharide conjugates of oligonucleotide phosphorothioates.
Bioconjugate chemistry 2008;19(12):2549-58.
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2008: Lehtinen Julia; Hyvönen Zanna; Subrizi Astrid; Bunjes Heike; Urtti Arto
Glycosaminoglycan-resistant and pH-sensitive lipid-coated DNA complexes produced by detergent removal method.
Journal of controlled release : official journal of the Controlled Release Society 2008;131(2):145-9.
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2008: del Amo Eva M; Urtti Arto; Yliperttula Marjo
Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;35(3):161-74.
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2008: Yliperttula Marjo; Chung Bong Geun; Navaladi Akshay; Manbachi Amir; Urtti Arto
High-throughput screening of cell responses to biomaterials.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;35(3):151-60.
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2008: Vuorimaa Elina; Urtti Arto; Seppänen Raimo; Lemmetyinen Helge; Yliperttula Marjo
Time-resolved fluorescence spectroscopy reveals functional differences of cationic polymer-DNA complexes.
Journal of the American Chemical Society 2008;130(35):11695-700.
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2008: Linnankoski Johanna; Ranta Veli-Pekka; Yliperttula Marjo; Urtti Arto
Passive oral drug absorption can be predicted more reliably by experimental than computational models--fact or myth.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;34(2-3):129-39.
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2008: Wikström J; Syväjärvi H; Urtti A; Yliperttula M
Kinetic simulation model of protein secretion and accumulation in the cell microcapsules.
The journal of gene medicine 2008;10(5):575-82.
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2008: Pappinen Sari; Hermansson Martin; Kuntsche Judith; Somerharju Pentti; Wertz Philip; Urtti Arto; Suhonen Marjukka
Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum.
Biochimica et biophysica acta 2008;1778(4):824-34.
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2008: Kuntsche Judith; Bunjes Heike; Fahr Alfred; Pappinen Sari; Rönkkö Seppo; Suhonen Marjukka; Urtti Arto
Interaction of lipid nanoparticles with human epidermis and an organotypic cell culture model.
International journal of pharmaceutics 2008;354(1-2):180-95.
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2008: Wikström Jonna; Elomaa Matti; Syväjärvi Heli; Kuokkanen Johanna; Yliperttula Marjo; Honkakoski Paavo; Urtti Arto
Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy.
Biomaterials 2008;29(7):869-76.
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2008: Del Amo Eva M; Urtti Arto
Current and future ophthalmic drug delivery systems. A shift to the posterior segment.
Drug discovery today 2008;13(3-4):135-43.
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2008: Vehanen Katja; Hornof Margit; Urtti Arto; Uusitalo Hannu
Peribulbar poloxamer for ocular drug delivery.
Acta ophthalmologica 2008;86(1):91-6.
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2008: Hornof Margit; de la Fuente Maria; Hallikainen Marjut; Tammi Raija H; Urtti Arto
Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells.
The journal of gene medicine 2008;10(1):70-80.
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2007: Paasonen Lauri; Romberg Birgit; Storm Gert; Yliperttula Marjo; Urtti Arto; Hennink Wim E
Temperature-sensitive poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents release.
Bioconjugate chemistry 2007;18(6):2131-6.
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2007: Pitkänen Leena; Ranta Veli-Pekka; Moilanen Hanna; Urtti Arto
Binding of betaxolol, metoprolol and oligonucleotides to synthetic and bovine ocular melanin, and prediction of drug binding to melanin in human choroid-retinal pigment epithelium.
Pharmaceutical research 2007;24(11):2063-70.
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2007: Kostiainen Mauri A; Szilvay Géza R; Lehtinen Julia; Smith David K; Linder Markus B; Urtti Arto; Ikkala Olli
Precisely defined protein-polymer conjugates: construction of synthetic DNA binding domains on proteins by using multivalent dendrons.
ACS nano 2007;1(2):103-13.
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2007: Paasonen Lauri; Laaksonen Timo; Johans Christoffer; Yliperttula Marjo; Kontturi Kyösti; Urtti Arto
Gold nanoparticles enable selective light-induced contents release from liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(1):86-93.
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2007: Siissalo Sanna; Laitinen Leena; Koljonen Maija; Vellonen Kati-Sisko; Kortejärvi Hanna; Urtti Arto; Hirvonen Jouni; Kaukonen Ann Marie
Effect of cell differentiation and passage number on the expression of efflux proteins in wild type and vinblastine-induced Caco-2 cell lines.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;67(2):548-54.
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2007: Männistö Marjo; Reinisalo Mika; Ruponen Marika; Honkakoski Paavo; Tammi Markku; Urtti Arto
Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans.
The journal of gene medicine 2007;9(6):479-87.
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2007: Toropainen Elisa; Hornof Margit; Kaarniranta Kai; Johansson Pinja; Urtti Arto
Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops.
The journal of gene medicine 2007;9(3):208-16.
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2007: Pappinen Sari; Tikkinen Sanna; Pasonen-Seppänen Sanna; Murtomäki Lasse; Suhonen Marjukka; Urtti Arto
Rat epidermal keratinocyte organotypic culture (ROC) compared to human cadaver skin: the effect of skin permeation enhancers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;30(3-4):240-50.
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2007: Kortejärvi H; Urtti A; Yliperttula M
Pharmacokinetic simulation of biowaiver criteria: the effects of gastric emptying, dissolution, absorption and elimination rates.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;30(2):155-66.
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2007: Mannermaa Eliisa; Urtti Arto; Kaarniranta Kai
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(18):2229-37.
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2006: Dubruel P; Urtti A; Schacht E H
Surface plasmon resonance as an elegant technique to study polyplex-GAG interactions.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e77-9.
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2006: Swennen I; Vermeersch V; Hornof M; Adriaens E; Remon J-P; Urtti A; Schacht E H
In-situ crosslinkable thermo-responsive hydrogels for drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e21-4.
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2006: Urtti Arto
Challenges and obstacles of ocular pharmacokinetics and drug delivery.
Advanced drug delivery reviews 2006;58(11):1131-5.
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2006: Mannermaa Eliisa; Vellonen Kati-Sisko; Urtti Arto
Drug transport in corneal epithelium and blood-retina barrier: emerging role of transporters in ocular pharmacokinetics.
Advanced drug delivery reviews 2006;58(11):1136-63.
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2006: Ranta Veli-Pekka; Urtti Arto
Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling.
Advanced drug delivery reviews 2006;58(11):1164-81.
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2006: Kortejärvi H; Malkki J; Marvola M; Urtti A; Yliperttula M; Pajunen P
Level A in vitro-in vivo correlation (IVIVC) model with Bayesian approach to formulation series.
Journal of pharmaceutical sciences 2006;95(7):1595-605.
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2006: Linnankoski Johanna; Mäkelä Johanna M; Ranta Veli-Pekka; Urtti Arto; Yliperttula Marjo
Computational prediction of oral drug absorption based on absorption rate constants in humans.
Journal of medicinal chemistry 2006;49(12):3674-81.
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2006: Paasonen Lauri; Korhonen Maarit; Yliperttula Marjo; Urtti Arto
Epidermal cell culture model with tight stratum corneum as a tool for dermal gene delivery studies.
International journal of pharmaceutics 2006;307(2):188-93.
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2006: Reinisalo Mika; Urtti Arto; Honkakoski Paavo
Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(2):437-43.
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2005: Pappinen Sari; Pasonen-Seppänen Sanna; Suhonen Marjukka; Tammi Raija; Urtti Arto
Rat epidermal keratinocyte organotypic culture (ROC) as a model for chemically induced skin irritation testing.
Toxicology and applied pharmacology 2005;208(3):233-41.
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2005: Hornof Margit; Toropainen Elisa; Urtti Arto
Cell culture models of the ocular barriers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;60(2):207-25.
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2005: Mannermaa Eliisa; Rönkkö Seppo; Ruponen Marika; Reinisalo Mika; Urtti Arto
Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer.
Current eye research 2005;30(5):345-53.
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2005: Männistö Marjo; Rönkkö Seppo; Mättö Mikko; Honkakoski Paavo; Hyttinen Mika; Pelkonen Jukka; Urtti Arto
The role of cell cycle on polyplex-mediated gene transfer into a retinal pigment epithelial cell line.
The journal of gene medicine 2005;7(4):466-76.
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2005: Pitkänen Leena; Ranta Veli-Pekka; Moilanen Hanna; Urtti Arto
Permeability of retinal pigment epithelium: effects of permeant molecular weight and lipophilicity.
Investigative ophthalmology & visual science 2005;46(2):641-6.
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2005: Ruponen Marika; Hyvönen Zanna; Urtti Arto; Ylä-Herttuala Seppo
Nonviral gene delivery methods in cardiovascular diseases.
Methods in molecular medicine 2005;108():315-28.
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2004: Hakkarainen Sanna; Kontturi Anna-Kaisa; Kontturi Kyösti; Urtti Arto
Electrochemical and calorimetric study of oligonucleotide complexation with cetylpyridinium chloride.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;23(4-5):371-7.
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2004: Lampela Pasi; Soininen Päivi; Puttonen Katja A; Ruponen Marika; Urtti Arto; Männistö Pekka T; Raasmaja Atso
Effect of cell-surface glycosaminoglycans on cationic carrier combined with low-MW PEI-mediated gene transfection.
International journal of pharmaceutics 2004;284(1-2):43-52.
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2004: Vellonen Kati-Sisko; Honkakoski Paavo; Urtti Arto
Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;23(2):181-8.
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2004: Hyvönen Zanna; Rönkkö Seppo; Toppinen Marjo-Riitta; Jääskeläinen Ilpo; Plotniece Aiva; Urtti Arto
Dioleoyl phosphatidylethanolamine and PEG-lipid conjugates modify DNA delivery mediated by 1,4-dihydropyridine amphiphiles.
Journal of controlled release : official journal of the Controlled Release Society 2004;99(1):177-90.
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2004: Mälkiä Annika; Murtomäki Lasse; Urtti Arto; Kontturi Kyösti
Drug permeation in biomembranes: in vitro and in silico prediction and influence of physicochemical properties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;23(1):13-47.
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2004: Tuovinen Laura; Ruhanen Eija; Kinnarinen Tarja; Rönkkö Seppo; Pelkonen Jukka; Urtti Arto; Peltonen Soili; Järvinen Kristiina
Starch acetate microparticles for drug delivery into retinal pigment epithelium-in vitro study.
Journal of controlled release : official journal of the Controlled Release Society 2004;98(3):407-13.
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2004: Ruponen Marika; Honkakoski Paavo; Tammi Markku; Urtti Arto
Cell-surface glycosaminoglycans inhibit cation-mediated gene transfer.
The journal of gene medicine 2004;6(4):405-14.
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2004: Korhonen Ossi; Kanerva Harri; Vidgren Mika; Urtti Arto; Ketolainen Jarkko
Evaluation of novel starch acetate-diltiazem controlled release tablets in healthy human volunteers.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(3):515-20.
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2004: Lampela Pasi; Soininen Päivi; Urtti Arto; Männistö Pekka T; Raasmaja Atso
Synergism in gene delivery by small PEIs and three different nonviral vectors.
International journal of pharmaceutics 2004;270(1-2):175-84.
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2004: Pitkänen Leena; Pelkonen Jukka; Ruponen Marika; Rönkkö Seppo; Urtti Arto
Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an in vitro bovine eye model.
The AAPS journal 2004;6(3):e25.
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2004: Jääskeläinen Ilpo; Lappalainen Katriina; Honkakoski Paavo; Urtti Arto
Requirements for delivery of active antisense oligonucleotides into cells with lipid carriers.
Methods in enzymology 2004;387():210-30.
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2003: Ruponen Marika; Honkakoski Paavo; Rönkkö Seppo; Pelkonen Jukka; Tammi Markku; Urtti Arto
Extracellular and intracellular barriers in non-viral gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2003;93(2):213-7.
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2003: Ranta Veli-Pekka; Laavola Mirka; Toropainen Elisa; Vellonen Kati-Sisko; Talvitie Anu; Urtti Arto
Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells.
Pharmaceutical research 2003;20(9):1409-16.
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2003: Marjukka Suhonen T; Pasonen-Seppänen Sanna; Kirjavainen Merja; Tammi Markku; Tammi Raija; Urtti Arto
Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(1):107-13.
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2003: Toropainen Elisa; Ranta Veli-Pekka; Vellonen Kati-Sisko; Palmgrén Joni; Talvitie Anu; Laavola Mirka; Suhonen Pekka; Hämäläinen Kaisa Mari; Auriola Seppo; Urtti Arto
Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(1):99-106.
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2003: Dubruel Peter; Dekie Luc; Christiaens Bart; Vanloo Berlinda; Rosseneu Maryvonne; Van De Kerckhove Joel; Mannisto Marjo; Urtti Arto; Schacht Etienne
Poly-l-glutamic acid derivatives as multifunctional vectors for gene delivery. Part B. Biological evaluation.
Biomacromolecules 2003;4(5):1177-83.
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2003: Reinisalo Mika; Urtti Arto; Honkakoski Paavo
Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells.
Biochimica et biophysica acta 2003;1628(3):169-76.
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2003: Pitkänen Leena; Ruponen Marika; Nieminen Jenni; Urtti Arto
Vitreous is a barrier in nonviral gene transfer by cationic lipids and polymers.
Pharmaceutical research 2003;20(4):576-83.
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2003: Peltola S; Saarinen-Savolainen P; Kiesvaara J; Suhonen T M; Urtti A
Microemulsions for topical delivery of estradiol.
International journal of pharmaceutics 2003;254(2):99-107.
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2003: Lampela Pasi; Elomaa Matti; Ruponen Marika; Urtti Arto; Männistö Pekka T; Raasmaja Atso
Different synergistic roles of small polyethylenimine and Dosper in gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(1):173-83.
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2002: Palmgrén Joni J; Toropainen Elisa; Auriola Seppo; Urtti Arto
Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols.
Journal of chromatography. A 2002;976(1-2):165-70.
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2002: Männistö Marjo; Vanderkerken Sylvie; Toncheva Veska; Elomaa Matti; Ruponen Marika; Schacht Etienne; Urtti Arto
Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2002;83(1):169-82.
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2002: Jääskeläinen Ilpo; Urtti Arto
Cell membranes as barriers for the use of antisense therapeutic agents.
Mini reviews in medicinal chemistry 2002;2(4):307-18.
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2002: Hyvönen Zanna; Ruponen Marika; Rönkkö Seppo; Suhonen Pekka; Urtti Arto
Extracellular and intracellular factors influencing gene transfection mediated by 1,4-dihydropyridine amphiphiles.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;15(5):449-60.
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2002: Ranta Veli-Pekka; Toropainen Elisa; Talvitie Anu; Auriola Seppo; Urtti Arto
Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;772(1):81-7.
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2002: Kontturi Anna-Kaisa; Kontturi Kyösti; Urtti Arto
Conformation and ion-binding of oligonucleotides.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;15(4):379-85.
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2002: Laine Krista; Järvinen Kristiina; Pate David W; Urtti Arto; Järvinen Tomi
Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides.
Investigative ophthalmology & visual science 2002;43(2):393-7.
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2002: Jääskeläinen Ilpo; Honkakoski Paavo; Urtti Arto
In vitro delivery of antisense oligonucleotides.
Cellular & molecular biology letters 2002;7(2):236-7.
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2001: Pasonen-Seppänen S; Suhonen T M; Kirjavainen M; Miettinen M; Urtti A; Tammi M; Tammi R
Formation of permeability barrier in epidermal organotypic culture for studies on drug transport.
The Journal of investigative dermatology 2001;117(5):1322-4.
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2001: Toropainen E; Ranta V P; Talvitie A; Suhonen P; Urtti A
Culture model of human corneal epithelium for prediction of ocular drug absorption.
Investigative ophthalmology & visual science 2001;42(12):2942-8.
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2001: Pasonen-Seppänen S; Suhonen T M; Kirjavainen M; Suihko E; Urtti A; Miettinen M; Hyttinen M; Tammi M; Tammi R
Vitamin C enhances differentiation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier.
Histochemistry and cell biology 2001;116(4):287-97.
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2001: Ruponen M; Rönkkö S; Honkakoski P; Pelkonen J; Tammi M; Urtti A
Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes.
The Journal of biological chemistry 2001;276(36):33875-80.
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2001: Honkakoski P; Jääskeläinen I; Kortelahti M; Urtti A
A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).
Pharmaceutical research 2001;18(2):146-50.
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2001: Urtti A; Johns S J; Sadée W
Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant.
AAPS pharmSci 2001;3(1):E6.
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2000: Hyvönen Z; Plotniece A; Reine I; Chekavichus B; Duburs G; Urtti A
Novel cationic amphiphilic 1,4-dihydropyridine derivatives for DNA delivery.
Biochimica et biophysica acta 2000;1509(1-2):451-66.
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2000: Valjakka-Koskela R; Hirvonen J; Mönkkönen J; Kiesvaara J; Antila S; Lehtonen L; Urtti A
Transdermal delivery of levosimendan.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;11(4):343-50.
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2000: Sutinen R; Paronen P; Saano V; Urtti A
Water-activated, pH-controlled patch in transdermal administration of timolol. II. Drug absorption and skin irritation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;11(1):25-31.
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2000: Sutinen R; Paronen P; Urtti A
Water-activated, pH-controlled patch in transdermal administration of timolol. I. Preclinical tests.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;11(1):19-24.
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2000: Jaskari T; Vuorio M; Kontturi K; Urtti A; Manzanares J A; Hirvonen J
Controlled transdermal iontophoresis by ion-exchange fiber.
Journal of controlled release : official journal of the Controlled Release Society 2000;67(2-3):179-90.
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2000: Jääskeläinen I; Peltola S; Honkakoski P; Mönkkönen J; Urtti A
A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(3):187-93.
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2000: Urtti A
Oligonucleotide theme.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(3):167.
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2000: Kirjavainen M; Urtti A; Mönkkönen J; Hirvonen J
Influence of lipids on the mannitol flux during transdermal iontophoresis in vitro.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(2):97-102.
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2000: Hämäläinen K M; Ranta V P; Auriola S; Urtti A
Enzymatic and permeation barrier of [D-Ala(2)]-Met-enkephalinamide in the anterior membranes of the albino rabbit eye.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;9(3):265-70.
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2000: Urtti A; Polansky J; Lui G M; Szoka F C
Gene delivery and expression in human retinal pigment epithelial cells: effects of synthetic carriers, serum, extracellular matrix and viral promoters.
Journal of drug targeting 2000;7(6):413-21.
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1999: Kanerva H; Kilkku O; Helminen A; Rouru J; Scheinin M; Huupponen R; Klebovich I; Drabant S; Urtti A
Pharmacokinetics and safety of deramciclane during multiple oral dosing.
International journal of clinical pharmacology and therapeutics 1999;37(12):589-97.
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1999: Kanerva H; Kilkku O; Heinonen E; Helminen A; Rouru J; Tarpila S; Scheinin M; Huupponen R; Klebovich I; Drabant S; Urtti A
The single dose pharmacokinetics and safety of deramciclane in healthy male volunteers.
Biopharmaceutics & drug disposition 1999;20(7):327-34.
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1999: Antopolsky M; Azhayeva E; Tengvall U; Auriola S; Jääskeläinen I; Rönkkö S; Honkakoski P; Urtti A; Lönnberg H; Azhayev A
Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties.
Bioconjugate chemistry 1999;10(4):598-606.
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1999: Marjukka Suhonen T; Bouwstra J A; Urtti A
Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations.
Journal of controlled release : official journal of the Controlled Release Society 1999;59(2):149-61.
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1999: Makkonen N; Salminen A; Rogers M J; Frith J C; Urtti A; Azhayeva E; Mönkkönen J
Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;8(2):109-18.
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1999: Kirjavainen M; Mönkkönen J; Saukkosaari M; Valjakka-Koskela R; Kiesvaara J; Urtti A
Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers.
Journal of controlled release : official journal of the Controlled Release Society 1999;58(2):207-14.
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1999: Kirjavainen M; Urtti A; Valjakka-Koskela R; Kiesvaara J; Mönkkönen J
Liposome-skin interactions and their effects on the skin permeation of drugs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;7(4):279-86.
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1999: Akerman S; Svarfvar B; Kontturi K; Näsman J; Urtti A; Paronen P; Järvinen K
Influence of ionic strength on drug adsorption onto and release from a poly(acrylic acid) grafted poly(vinylidene fluoride) membrane.
International journal of pharmaceutics 1999;178(1):67-75.
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1999: Turunen M P; Hiltunen M O; Ruponen M; Virkamäki L; Szoka F C; Urtti A; Ylä-Herttuala S
Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes.
Gene therapy 1999;6(1):6-11.
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1999: Ruponen M; Ylä-Herttuala S; Urtti A
Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies.
Biochimica et biophysica acta 1999;1415(2):331-41.
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1998: Hämäläinen K M; Määttä E; Piirainen H; Marianne Sarkola; Väisänen A; Ranta V P; Urtti A
Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride).
Journal of controlled release : official journal of the Controlled Release Society 1998;56(1-3):273-83.
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1998: Kanerva H; Huuskonen H; Alhonen-Raatesalmi A; Nevalainen T; Urtti A
Pharmacokinetics of deramciclane in dogs after single oral and intravenous dosing and multiple oral dosing.
Biopharmaceutics & drug disposition 1998;19(8):531-9.
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1998: Kanerva H; Klebovich I; Drabant S; Urtti A; Nevalainen T
Different absorption profiles of deramciclane in man and in dog.
The Journal of pharmacy and pharmacology 1998;50(10):1087-93.
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1998: Saarinen-Savolainen P; Järvinen T; Araki-Sasaki K; Watanabe H; Urtti A
Evaluation of cytotoxicity of various ophthalmic drugs, eye drop excipients and cyclodextrins in an immortalized human corneal epithelial cell line.
Pharmaceutical research 1998;15(8):1275-80.
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1998: Suhonen P; Järvinen T; Koivisto S; Urtti A
Different effects of pH on the permeation of pilocarpine and pilocarpine prodrugs across the isolated rabbit cornea.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;6(3):169-76.
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1998: Ranta V P; Hämäläinen K M; Auriola S; Urtti A
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection II. Application to ocular permeability studies in vitro.
Journal of chromatography. B, Biomedical sciences and applications 1998;709(1):1-10.
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1998: Akerman S; Viinikka P; Svarfvar B; Järvinen K; Kontturi K; Näsman J; Urtti A; Paronen P
Transport of drugs across porous ion exchange membranes.
Journal of controlled release : official journal of the Controlled Release Society 1998;50(1-3):153-66.
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1998: Pate D W; Järvinen K; Urtti A; Mahadevan V; Järvinen T
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits.
Life sciences 1998;63(24):2181-8.
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1997: Pate D W; Järvinen K; Urtti A; Jarho P; Mahadevan V; Järvinen T
Effects of topical alpha-substituted anandamides on intraocular pressure in normotensive rabbits.
Pharmaceutical research 1997;14(12):1738-43.
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1997: Azhayeva E; Azhayev A; Auriola S; Tengvall U; Urtti A; Lönnberg
Inhibitory properties of double-helix-forming circular oligonucleotides.
Nucleic acids research 1997;25(24):4954-61.
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1997: Hämäläinen K M; Kananen K; Auriola S; Kontturi K; Urtti A
Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera.
Investigative ophthalmology & visual science 1997;38(3):627-34.
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1996: Kirjavainen M; Urtti A; Jääskeläinen I; Suhonen T M; Paronen P; Valjakka-Koskela R; Kiesvaara J; Mönkkönen J
Interaction of liposomes with human skin in vitro--the influence of lipid composition and structure.
Biochimica et biophysica acta 1996;1304(3):179-89.
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1996: Jarho P; Järvinen K; Urtti A; Stella V J; Järvinen T
Modified beta-cyclodextrin (SBE7-beta-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits.
The Journal of pharmacy and pharmacology 1996;48(3):263-9.
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1996: Ylitalo R; Mönkkönen J; Urtti A; Ylitalo P
Accumulation of bisphosphonates in the aorta and some other tissues of healthy and atherosclerotic rabbits.
The Journal of laboratory and clinical medicine 1996;127(2):200-6.
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1996: Pate D W; Järvinen K; Urtti A; Jarho P; Fich M; Mahadevan V; Järvinen T
Effects of topical anandamides on intraocular pressure in normotensive rabbits.
Life sciences 1996;58(21):1849-60.
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1996: Jarho P; Urtti A; Järvinen K; Pate D W; Järvinen T
Hydroxypropyl-beta-cyclodextrin increases aqueous solubility and stability of anandamide.
Life sciences 1996;58(10):PL 181-5.
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1995: Jarho P; Urtti A; Järvinen T
Hydroxypropyl-beta-cyclodextrin increases the aqueous solubility and stability of pilocarpine prodrugs.
Pharmaceutical research 1995;12(9):1371-5.
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1995: Pate D W; Järvinen K; Urtti A; Jarho P; Järvinen T
Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits.
Current eye research 1995;14(9):791-7.
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1995: Pennanen N; Lapinjoki S; Urtti A; Mönkkönen J
Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro.
Pharmaceutical research 1995;12(6):916-22.
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1995: Pennanen N; Lapinjoki S; Palander A; Urtti A; Mönkkönen J
Macrophage-like RAW 264 cell line and time-resolved fluoroimmunoassay (TRFIA) as tools in screening drug effects on cytokine secretion.
International journal of immunopharmacology 1995;17(6):475-80.
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1995: Järvinen T; Poikolainen M; Suhonen P; Vepsäläinen J; Alaranta S; Urtti A
Comparison of enzymatic hydrolysis of pilocarpine prodrugs in human plasma, rabbit cornea, and butyrylcholinesterase solutions.
Journal of pharmaceutical sciences 1995;84(5):656-60.
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1995: Suhonen P; Järvinen T; Lehmussaari K; Reunamäki T; Urtti A
Ocular absorption and irritation of pilocarpine prodrug is modified with buffer, polymer, and cyclodextrin in the eyedrop.
Pharmaceutical research 1995;12(4):529-33.
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1995: Järvinen T; Järvinen K; Urtti A; Thompson D; Stella V J
Sulfobutyl ether beta-cyclodextrin (SBE-beta-CD) in eyedrops improves the tolerability of a topically applied pilocarpine prodrug in rabbits.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1995;11(2):95-106.
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1994: Lappalainen K; Urtti A; Söderling E; Jääskeläinen I; Syrjänen K; Syrjänen S
Cationic liposomes improve stability and intracellular delivery of antisense oligonucleotides into CaSki cells.
Biochimica et biophysica acta 1994;1196(2):201-8.
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1994: Jääskeläinen I; Mönkkönen J; Urtti A
Oligonucleotide-cationic liposome interactions. A physicochemical study.
Biochimica et biophysica acta 1994;1195(1):115-23.
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1994: Urtti A; Rouhiainen H; Kaila T; Saano V
Controlled ocular timolol delivery: systemic absorption and intraocular pressure effects in humans.
Pharmaceutical research 1994;11(9):1278-82.
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1994: Lappalainen K; Jääskeläinen I; Syrjänen K; Urtti A; Syrjänen S
Comparison of cell proliferation and toxicity assays using two cationic liposomes.
Pharmaceutical research 1994;11(8):1127-31.
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1994: Jääskeläinen I; Urtti A
Liquid chromatography determination of liposome components using a light-scattering evaporative detector.
Journal of pharmaceutical and biomedical analysis 1994;12(8):977-82.
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1994: Turunen T M; Urtti A; Paronen P; Audus K L; Rytting J H
Effect of some penetration enhancers on epithelial membrane lipid domains: evidence from fluorescence spectroscopy studies.
Pharmaceutical research 1994;11(2):288-94.
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1994: Lappalainen K; Urtti A; Jääskeläinen I; Syrjänen K; Syrjänen S
Cationic liposomes mediated delivery of antisense oligonucleotides targeted to HPV 16 E7 mRNA in CaSki cells.
Antiviral research 1994;23(2):119-30.
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1994: Urtti A
Delivery of antiglaucoma drugs: ocular vs systemic absorption.
Journal of ocular pharmacology 1994;10(1):349-57.
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1994: Mönkkönen J; Pennanen N; Lapinjoki S; Urtti A
Clodronate (dichloromethylene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells.
Life sciences 1994;54(14):PL229-34.
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1994: Mönkkönen J; Taskinen M; Auriola S O; Urtti A
Growth inhibition of macrophage-like and other cell types by liposome-encapsulated, calcium-bound, and free bisphosphonates in vitro.
Journal of drug targeting 1994;2(4):299-308.
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1993: Auriola S O; Rönkkö K M; Urtti A
Determination of polyethylene glycols by high-performance liquid chromatography-thermospray mass spectrometry.
Journal of pharmaceutical and biomedical analysis 1993;11(10):1027-32.
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1993: MacDonald E; Vartiainen J; Jäsberg K; Vuorilehto L; Salonen J S; Urtti A
Systemic absorption and systemic effects of ocularly administered dexmedetomidine in rabbits.
Current eye research 1993;12(5):451-60.
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1993: Urtti A; Salminen L
Minimizing systemic absorption of topically administered ophthalmic drugs.
Survey of ophthalmology 1993;37(6):435-56.
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1993: Kontturi K; Murtomäki L; Hirvonen J; Paronen P; Urtti A
Electrochemical characterization of human skin by impedance spectroscopy: the effect of penetration enhancers.
Pharmaceutical research 1993;10(3):381-5.
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1993: Saettone M F; Chetoni P; Cappanera L; Conte U; Finne U; Järvinen K; Salivirta J; Urtti A
Intraocular pressure reduction and systemic absorption of timolol after administration of one side-coated inserts in rabbits.
Journal of ocular pharmacology 1993;9(1):1-12.
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1992: Järvinen K; Urtti A
Cardiac effects of different eyedrop preparations of timolol in rabbits.
Current eye research 1992;11(5):469-73.
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1992: Vartiainen J; MacDonald E; Urtti A; Rouhiainen H; Virtanen R
Dexmedetomidine-induced ocular hypotension in rabbits with normal or elevated intraocular pressures.
Investigative ophthalmology & visual science 1992;33(6):2019-23.
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1992: Järvinen T; Suhonen P; Auriola S; Vepsäläinen J; Urtti A; Peura P
Synthesis and analysis of O,O'-dicarboxylate (dibenzyl) bispilocarpates as possible prodrugs of pilocarpine.
Journal of pharmaceutical and biomedical analysis 1992;10(2-3):153-61.
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1992: Järvinen K; Urtti A
Duration and long-term efficacy of phenylephrine-induced reduction in the systemic absorption of ophthalmic timolol in rabbits.
Journal of ocular pharmacology 1992;8(2):91-8.
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1991: Suhonen P; Järvinen T; Rytkönen P; Peura P; Urtti A
Improved corneal pilocarpine permeability with O,O'-(1,4-xylylene) bispilocarpic acid ester double prodrugs.
Pharmaceutical research 1991;8(12):1539-42.
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1991: Finne U; Rönkkö K; Urtti A
Timolol release from matrices of monoesters of poly(vinyl methyl ether-maleic anhydride): effects of polymer molecular weight and a basic additive.
Journal of pharmaceutical sciences 1991;80(7):670-3.
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1991: Hirvonen J; Rytting J H; Paronen P; Urtti A
Dodecyl N,N-dimethylamino acetate and azone enhance drug penetration across human, snake, and rabbit skin.
Pharmaceutical research 1991;8(7):933-7.
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1991: Järvinen T; Suhonen P; Naumanen H; Urtti A; Peura P
Determination of physicochemical properties, stability in aqueous solutions and serum hydrolysis of pilocarpic acid diesters.
Journal of pharmaceutical and biomedical analysis 1991;9(9):737-45.
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1991: Järvinen T; Auriola S; Peura P; Suhonen P; Urtti A; Vepsäläinen J
Synthesis and identification of pilocarpic acid diesters, prodrugs of pilocarpine.
Journal of pharmaceutical and biomedical analysis 1991;9(6):457-64.
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1990: Kyyrönen K; Urtti A
Improved ocular: systemic absorption ratio of timolol by viscous vehicle and phenylephrine.
Investigative ophthalmology & visual science 1990;31(9):1827-33.
-
1990: Kyyrönen K; Urtti A
Effects of epinephrine pretreatment and solution pH on ocular and systemic absorption of ocularly applied timolol in rabbits.
Journal of pharmaceutical sciences 1990;79(8):688-91.
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1989: Mönkkönen J; Urtti A; Paronen P; Elo H A; Ylitalo P
The uptake of clodronate (dichloromethylene bisphosphonate) by macrophages in vivo and in vitro.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(6):690-3.
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1989: Urtti A; Kyyrönen K
Ophthalmic epinephrine, phenylephrine, and pilocarpine affect the systemic absorption of ocularly applied timolol.
Journal of ocular pharmacology 1989;5(2):127-32.
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1988: Urtti A; Sendo T; Pipkin J D; Rork G; Repta A J
Application site dependent ocular absorption of timolol.
Journal of ocular pharmacology 1988;4(4):335-43.
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1987: Huupponen R; Kaila T; Salminen L; Urtti A
The pharmacokinetics of ocularly applied timolol in rabbits.
Acta ophthalmologica 1987;65(1):63-6.
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1985: Urtti A; Salminen L
Concentration-dependent precorneal loss of pilocarpine in rabbit eyes.
Acta ophthalmologica 1985;63(5):502-6.
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1985: Urtti A O; Salminen L M
Pilocarpine and acetylcholine synthesis.
Archives of ophthalmology 1985;103(4):477.
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1985: Urtti A; Salminen L
A comparison between iris-ciliary body concentration and receptor affinity of timolol.
Acta ophthalmologica 1985;63(1):16-8.
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1984: Urtti A; Salminen L; Periviita L
Ocular distribution of topically applied adrenaline in albino and pigmented rabbits.
Acta ophthalmologica 1984;62(5):753-62.
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1984: Salminen L; Urtti A
Disposition of ophthalmic timolol in treated and untreated rabbit eyes. A multiple and single dose study.
Experimental eye research 1984;38(2):203-6.
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1983: Salminen L; Urtti A; Kujari H; Juslin M
Prolonged pulse-entry of pilocarpine with a soluble drug insert.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 1983;221(2):96-9.
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1982: Saano V; Urtti A
Tofizopam modulates the affinity of benzodiazepine receptors in the rat brain.
Pharmacology, biochemistry, and behavior 1982;17(2):367-9.
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1981: Saano V; Urtti A; Airaksinen M M
Increase in 3H-flunitrazepam binding in vitro and in vivo to rat brain benzodiazepine receptors by tofizopam, a 3,4-benzo-diazepine.
Pharmacological research communications 1981;13(1):75-85.
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