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Neil Bulleid

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TOP 3
Neil J Bulleid
Disulfide bond formation in the mammalian endoplasmic reticulum.
Neil J Bulleid
Solving the mystery of procollagen chain selectivity.
Zhenbo Cao; Richard J Cogdell; Aleksander W Roszak; Timothy J Tavender; Neil J Bulleid
Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle.

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All Publications

2012: Neil J Bulleid
Disulfide bond formation in the mammalian endoplasmic reticulum.
Cold Spring Harbor perspectives in biology 2012;4(11):.
2012: Neil J Bulleid
Solving the mystery of procollagen chain selectivity.
Nature structural & molecular biology 2012;19(10):977-8.
2011: Zhenbo Cao; Richard J Cogdell; Aleksander W Roszak; Timothy J Tavender; Neil J Bulleid
Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle.
The Journal of biological chemistry 2011;286(49):42257-66.
2011: Neil J Bulleid; Lars Ellgaard
Multiple ways to make disulfides.
Trends in biochemical sciences 2011;36(9):485-92.
2011: Marcel Van Lith; Graeme Milligan; John Pediani; Shweta Tiwari; Neil J Bulleid
Real-time monitoring of redox changes in the mammalian endoplasmic reticulum.
Journal of cell science 2011;124(Pt 14):2349-56.
2011: Ineke Braakman; Neil J Bulleid
Protein folding and modification in the mammalian endoplasmic reticulum.
Annual review of biochemistry 2011;80():71-99.
2011: Shweta Tiwari; Janet Askari; Martin J Humphries; Neil J Bulleid
Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking.
Journal of cell science 2011;124(Pt 10):1672-80.
2010: Timothy J Tavender; Jennifer J Springate; Neil J Bulleid
Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum.
The EMBO journal 2010;29(24):4185-97.
2010: Timothy J Tavender; Neil J Bulleid
Molecular mechanisms regulating oxidative activity of the Ero1 family in the endoplasmic reticulum.
Antioxidants & redox signaling 2010;13(8):1177-87.
2010: Joseph E Chambers; Timothy J Tavender; Ojore B V Oka; Stacey Warwood; David Knight; Neil J Bulleid
The reduction potential of the active site disulfides of human protein disulfide isomerase limits oxidation of the enzyme by Ero1α.
The Journal of biological chemistry 2010;285(38):29200-7.
2010: Timothy J Tavender; Neil J Bulleid
Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation.
Journal of cell science 2010;123(Pt 15):2672-9.
2010: Lindsay J Gleghorn; Dorothy Trump; Neil J Bulleid
Wild-type and missense mutants of retinoschisin co-assemble resulting in either intracellular retention or incorrect assembly of the functionally active octamer.
The Biochemical journal 2010;425(1):275-83.
2009: Catherine E Jessop; Rachel H Watkins; Jennifer J Simmons; Mohammed Tasab; Neil J Bulleid
Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins.
Journal of cell science 2009;122(Pt 23):4287-95.
2009: Catherine E Jessop; Timothy J Tavender; Rachel H Watkins; Joseph E Chambers; Neil J Bulleid
Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin.
The Journal of biological chemistry 2009;284(4):2194-202.
2008: Karl M Baker; Seema Chakravarthi; Kevin P Langton; Alyson M Sheppard; Hui Lu; Neil J Bulleid
Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidation.
The EMBO journal 2008;27(22):2988-97.
2008: Timothy J Tavender; Alyson M Sheppard; Neil J Bulleid
Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells.
The Biochemical journal 2008;411(1):191-9.
2008: Joseph E Chambers; Catherine E Jessop; Neil J Bulleid
Formation of a major histocompatibility complex class I tapasin disulfide indicates a change in spatial organization of the peptide-loading complex during assembly.
The Journal of biological chemistry 2008;283(4):1862-9.
2007: Seema Chakravarthi; Catherine E Jessop; Martin Willer; Colin J Stirling; Neil J Bulleid
Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1.
The Biochemical journal 2007;404(3):403-11.
2007: Judit Wahlman; George N DeMartino; William R Skach; Neil J Bulleid; Jeffrey L Brodsky; Arthur E Johnson
Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.
Cell 2007;129(5):943-55.
2007: Catherine E Jessop; Seema Chakravarthi; Natalio Garbi; Günter J Hämmerling; Simon Lovell; Neil J Bulleid
ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.
The EMBO journal 2007;26(1):28-40.
2006: Khalil Saleki; Nichola Hartigan; Marcel van Lith; Neil J Bulleid; Adam M Benham
Differential oxidation of HLA-B2704 and HLA-B2705 in lymphoblastoid and transfected adherent cells.
Antioxidants & redox signaling 2006;8(3-4):292-9.
2006: Seema Chakravarthi; Catherine E Jessop; Neil J Bulleid
The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress.
EMBO reports 2006;7(3):271-5.
2005: Sanjika Dias-Gunasekara; Jacob Gubbens; Marcel Van Lith; Christine Dunne; J A Gareth Williams; Ritu Kataky; David Scoones; Adrian J Lapthorn; Neil J Bulleid; Adam M Benham
Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1beta.
The Journal of biological chemistry 2005;280(38):33066-75.
2005: Elizabeth O'Connor; Birgit Eisenhaber; Jane Dalley; Tao Wang; Caroline Missen; Neil J Bulleid; Paul N Bishop; Dorothy Trump
Species specific membrane anchoring of nyctalopin, a small leucine-rich repeat protein.
Human molecular genetics 2005;14(13):1877-87.
2005: Ingo Dierking; O Marshall; J Wright; Neil J Bulleid
Annihilation dynamics of umbilical defects in nematic liquid crystals under applied electric fields.
Physical review. E, Statistical, nonlinear, and soft matter physics 2005;71(6 Pt 1):061709.
2004: Catherine E Jessop; Neil J Bulleid
Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells.
The Journal of biological chemistry 2004;279(53):55341-7.
2004: Catherine E Jessop; Seema Chakravarthi; R H Watkins; Neil J Bulleid
Oxidative protein folding in the mammalian endoplasmic reticulum.
Biochemical Society transactions 2004;32(Pt 5):655-8.
2004: Seema Chakravarthi; Neil J Bulleid
Glutathione is required to regulate the formation of native disulfide bonds within proteins entering the secretory pathway.
The Journal of biological chemistry 2004;279(38):39872-9.
2003: Jane A Dalley; Neil J Bulleid
The endoplasmic reticulum (ER) translocon can differentiate between hydrophobic sequences allowing signals for glycosylphosphatidylinositol anchor addition to be fully translocated into the ER lumen.
The Journal of biological chemistry 2003;278(51):51749-57.
2003: Jane A Dalley; Neil J Bulleid
How does the translocon differentiate between hydrophobic sequences that form part of either a GPI (glycosylphosphatidylinositol)-anchor signal or a stop transfer sequence?
Biochemical Society transactions 2003;31(Pt 6):1257-9.
2003: Neil J Bulleid
Protein disulphide isomerase.
Current biology : CB 2003;13(10):R380.
2003: Eileithyia Swanton; Neil J Bulleid
Protein folding and translocation across the endoplasmic reticulum membrane.
Molecular membrane biology 2003;20(2):99-104.
2003: Cornelia M Wilson; Neil J Bulleid
Investigation of folding and degradation of mutant proteins synthesized in semipermeabilized cells.
Methods in molecular biology (Clifton, N.J.) 2003;232():295-312.
2002: Lumb Richard; Neil J Bulleid
Is protein disulfide isomerase a redox-dependent molecular chaperone?
The EMBO journal 2002;21(24):6763-70.
2002: Mohammed Tasab; Lynsey Jenkinson; Neil J Bulleid
Sequence-specific recognition of collagen triple helices by the collagen-specific molecular chaperone HSP47.
The Journal of biological chemistry 2002;277(38):35007-12.
2001: MJ Bottomley; MR Batten; Lumb Richard; Neil J Bulleid
Quality control in the endoplasmic reticulum: PDI mediates the ER retention of unassembled procollagen C-propeptides.
Current biology : CB 2001;11(14):1114-8.
2001: T D Spurway; Jane A Dalley; Stephen High; Neil J Bulleid
Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p.
The Journal of biological chemistry 2001;276(19):15975-82.
2001: Mark Farmery; Neil J Bulleid
Major histocompatibility class I folding, assembly, and degradation: a paradigm for two-stage quality control in the endoplasmic reticulum.
Progress in nucleic acid research and molecular biology 2001;67():235-68.
2000: Adam M Benham; A Cabibbo; Anna Fassio; Neil J Bulleid; Roberto Sitia; Ineke Braakman
The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha.
The EMBO journal 2000;19(17):4493-502.
2000: M Pagani; marco fabbri; C Benedetti; Anna Fassio; S Pilati; Neil J Bulleid; A Cabibbo; Roberto Sitia
Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response.
The Journal of biological chemistry 2000;275(31):23685-92.
2000: Cornelia M Wilson; Mark Farmery; Neil J Bulleid
Pivotal role of calnexin and mannose trimming in regulating the endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain.
The Journal of biological chemistry 2000;275(28):21224-32.
2000: Mark Farmery; Scott Allen; A J Allen; Neil J Bulleid
The role of ERp57 in disulfide bond formation during the assembly of major histocompatibility complex class I in a synchronized semipermeabilized cell translation system.
The Journal of biological chemistry 2000;275(20):14933-8.
2000: Mohammed Tasab; MR Batten; Neil J Bulleid
Hsp47: a molecular chaperone that interacts with and stabilizes correctly-folded procollagen.
The EMBO journal 2000;19(10):2204-11.
2000: A Cabibbo; M Pagani; marco fabbri; M Rocchi; Mark Farmery; Neil J Bulleid; Roberto Sitia
ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum.
The Journal of biological chemistry 2000;275(7):4827-33.
2000: Neil J Bulleid; D C John; Karl Kadler
Recombinant expression systems for the production of collagen.
Biochemical Society transactions 2000;28(4):350-3.
2000: R R Wilson; Neil J Bulleid
Semi-permeabilized cells to study procollagen assembly.
Methods in molecular biology (Clifton, N.J.) 2000;139():1-9.
1999: A R Walmsley; MR Batten; U Lad; Neil J Bulleid
Intracellular retention of procollagen within the endoplasmic reticulum is mediated by prolyl 4-hydroxylase.
The Journal of biological chemistry 1999;274(21):14884-92.
1999: D C John; R Watson; Alex J Kind; A R Scott; Karl Kadler; Neil J Bulleid
Expression of an engineered form of recombinant procollagen in mouse milk.
Nature biotechnology 1999;17(4):385-9.
1999: Stephen McLaughlin; S N Conn; Neil J Bulleid
Folding and assembly of type X collagen mutants that cause metaphyseal chondrodysplasia-type schmid. Evidence for co-assembly of the mutant and wild-type chains and binding to molecular chaperones.
The Journal of biological chemistry 1999;274(11):7570-5.
1998: Neil J Bulleid; R R Wilson; U Lad
A cautionary note when using pepsin as a probe for the formation of a collagen triple helix.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(3):233-6.
1998: Stephen McLaughlin; Neil J Bulleid
Thiol-independent interaction of protein disulphide isomerase with type X collagen during intra-cellular folding and assembly.
The Biochemical journal 1998;331 ( Pt 3)():793-800.
1998: R Wilson; JF Lees; Neil J Bulleid
Protein disulfide isomerase acts as a molecular chaperone during the assembly of procollagen.
The Journal of biological chemistry 1998;273(16):9637-43.
1998: Stephen McLaughlin; Neil J Bulleid
Molecular recognition in procollagen chain assembly.
Matrix biology : journal of the International Society for Matrix Biology 1998;16(7):369-77.
1997: Neil J Bulleid; Jane A Dalley; JF Lees
The C-propeptide domain of procollagen can be replaced with a transmembrane domain without affecting trimer formation or collagen triple helix folding during biosynthesis.
The EMBO journal 1997;16(22):6694-701.
1997: Scott Allen; Neil J Bulleid
Calnexin and calreticulin bind to enzymically active tissue-type plasminogen activator during biosynthesis and are not required for folding to the native conformation.
The Biochemical journal 1997;328 ( Pt 1)():113-9.
1997: JF Lees; Mohammed Tasab; Neil J Bulleid
Identification of the molecular recognition sequence which determines the type-specific assembly of procollagen.
The EMBO journal 1997;16(5):908-16.
1997: Jason D Oliver; F J van der Wal; Neil J Bulleid; Stephen High
Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins.
Science (New York, N.Y.) 1997;275(5296):86-8.
1996: D C John; Neil J Bulleid
Intracellular dissociation and reassembly of prolyl 4-hydroxylase:the alpha-subunits associated with the immunoglobulin-heavy-chain binding protein (BiP) allowing reassembly with the beta-subunit.
The Biochemical journal 1996;317 ( Pt 3)():659-65.
1996: Neil J Bulleid; R Wilson; J F Lees
Type-III procollagen assembly in semi-intact cells: chain association, nucleation and triple-helix folding do not require formation of inter-chain disulphide bonds but triple-helix nucleation does require hydroxylation.
The Biochemical journal 1996;317 ( Pt 1)():195-202.
1995: Ralf Jacob; Neil J Bulleid; Hassan Y Naim
Folding of human intestinal lactase-phlorizin hydrolase.
The Journal of biological chemistry 1995;270(31):18678-84.
1995: R Wilson; A J Allen; J Oliver; J L Brookman; Stephen High; Neil J Bulleid
The translocation, folding, assembly and redox-dependent degradation of secretory and membrane proteins in semi-permeabilized mammalian cells.
The Biochemical journal 1995;307 ( Pt 3)():679-87.
1995: S Allen; Hassan Y Naim; Neil J Bulleid
Intracellular folding of tissue-type plasminogen activator. Effects of disulfide bond formation on N-linked glycosylation and secretion.
The Journal of biological chemistry 1995;270(9):4797-804.
1994: D C John; Neil J Bulleid
Prolyl 4-hydroxylase: defective assembly of alpha-subunit mutants indicates that assembled alpha-subunits are intramolecularly disulfide bonded.
Biochemistry 1994;33(47):14018-25.
1994: J F Lees; Neil J Bulleid
The role of cysteine residues in the folding and association of the COOH-terminal propeptide of types I and III procollagen.
The Journal of biological chemistry 1994;269(39):24354-60.
1993: R B Middleton; Neil J Bulleid
Reconstitution of the folding pathway of collagen in a cell-free system: formation of correctly aligned and hydroxylated triple helices.
The Biochemical journal 1993;296 ( Pt 2)():511-7.
1993: D C John; Michael E Grant; Neil J Bulleid
Cell-free synthesis and assembly of prolyl 4-hydroxylase: the role of the beta-subunit (PDI) in preventing misfolding and aggregation of the alpha-subunit.
The EMBO journal 1993;12(4):1587-95.
1993: Neil J Bulleid
Protein disulfide-isomerase: role in biosynthesis of secretory proteins.
Advances in protein chemistry 1993;44():125-50.
1992: Neil J Bulleid; Rhonda Bassel-Duby; R B Freedman; J F Sambrook; Mary-Jane Gething
Cell-free synthesis of enzymically active tissue-type plasminogen activator. Protein folding determines the extent of N-linked glycosylation.
The Biochemical journal 1992;286 ( Pt 1)():275-80.
1991: Didan Steven; M M Griffin; Neil J Bulleid; B S Brown
Exchange of inhibitors and proteases at tumour cell surfaces.
Biochemical Society transactions 1991;19(4):427S.
1991: Didan Steven; M M Griffin; Neil J Bulleid; Heinz Maier; I A Born
Studies on the interaction and exchange of inhibitors and proteases on the surface of tumour cells in frozen sections.
Anticancer research 1991;11(6):2117-22.