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María Bullido

Research Profile

Disorders

Alzheimer's Disease

Chemicals & Drugs

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Publications

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María Recuero; Isabel Sastre; Fernando Valdivieso; Jesús Aldudo; Victor A Munive; María J Bullido
A free radical-generating system regulates AβPP metabolism/processing: involvement of the ubiquitin/proteasome and autophagy/lysosome pathways.
Olga Calero; Jordi Clarimón; Jesús de Pedro-Cuesta; Isidro Ferrer; Ana Frank-García; Rafael Hortigüela; Alberto Lleó; Pablo Martínez-Martín; Alberto Rábano; María Jesús Rey; Isabel Sastre; María J Bullido; Miguel Calero
Genetic variability of the gene cluster CALHM 1-3 in sporadic Creutzfeldt-Jakob disease.
Soraya Santana; Fernando Valdivieso; María J Bullido; María Recuero; Jesús Aldudo
Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells.

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All Publications

2013: María Recuero; Isabel Sastre; Fernando Valdivieso; Jesús Aldudo; Victor A Munive; María J Bullido
A free radical-generating system regulates AβPP metabolism/processing: involvement of the ubiquitin/proteasome and autophagy/lysosome pathways.
Journal of Alzheimer's disease : JAD 2013;34(3):637-47.
2012: Olga Calero; Jordi Clarimón; Jesús de Pedro-Cuesta; Isidro Ferrer; Ana Frank-García; Rafael Hortigüela; Alberto Lleó; Pablo Martínez-Martín; Alberto Rábano; María Jesús Rey; Isabel Sastre; María J Bullido; Miguel Calero
Genetic variability of the gene cluster CALHM 1-3 in sporadic Creutzfeldt-Jakob disease.
Prion 2012;6(4):407-12.
2012: Soraya Santana; Fernando Valdivieso; María J Bullido; María Recuero; Jesús Aldudo
Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells.
Neurobiology of aging 2012;33(2):430.e19-33.
2012: Olga Calero; Jordi Clarimón; Jesús de Pedro-Cuesta; Isidro Ferrer; Ana Frank-García; Alberto Lleó; Pablo Martínez-Martín; Alberto Rábano; María Jesús Rey; Isabel Sastre; María J Bullido; Miguel Calero
A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease.
PloS one 2012;7(8):e43926.
2012: Soraya Santana; Fernando Valdivieso; María J Bullido; María Recuero; Jesús Aldudo
Herpes simplex virus type I induces an incomplete autophagic response in human neuroblastoma cells.
Journal of Alzheimer's disease : JAD 2012;30(4):815-31.
2011: Sebastián Cervantes; Jordi Clarimón; Onofre Combarros; Francisco Coria; Ana Frank-García; Isabel Lamet; Alberto Lleó; Elena Lorenzo; Eloy Rodríguez-Rodríguez; Marcel Rosich; Lluis Samaranch; Pascual Sánchez-Juan; Jose M Vidal-Taboada; Elisabet Vilella; Elena Alonso; María J Bullido; Pau Pastor
Genetic variation in APOE cluster region and Alzheimer's disease risk.
Neurobiology of aging 2011;32(11):2107.e7-17.
2011: José Luis Vázquez-Higuera; Ana Martínez-García; Pascual Sánchez-Juan; Eloy Rodríguez-Rodríguez; Ignacio Mateo; Ana Pozueta; Ana Frank; Fernando Valdivieso; José Berciano; María J Bullido; Onofre Combarros
Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort.
Neurobiology of aging 2011;32(3):550.e5-9.
2011: José L Vázquez-Higuera; José Berciano; María J Bullido; Miguel Calero; José L Dobato; Ana Frank-García; Ignacio Mateo; Ana Pozueta; Eloy Rodríguez-Rodríguez; Pascual Sánchez-Juan; Fernando Valdivieso; Onofre Combarros
Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.
BMC research notes 2011;4():327.
2011: José Luis Vázquez-Higuera; José Berciano; María J Bullido; Miguel Calero; José L Dobato; Ana Frank-García; Ignacio Mateo; Ana Pozueta; Eloy Rodríguez-Rodríguez; Pascual Sánchez-Juan; Fernando Valdivieso; Onofre Combarros
Genetic variation in the tau kinases pathway may modify the risk and age at onset of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;27(2):291-7.
2011: Olga Calero; Jordi Clarimón; Jesús de Pedro-Cuesta; Isidro Ferrer; Ana Frank-García; Teresa Gómez-Isla; Alberto Lleó; Pablo Martínez-Martín; Alberto Rábano; María Jesús Rey; Fernando Valdivieso; Rafael Blesa; María J Bullido; Miguel Calero
Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases.
PloS one 2011;6(7):e22090.
2010: María Recuero; Teresa Muñoz; Jesús Aldudo; Marta Subías; María J Bullido; Fernando Valdivieso
A free radical-generating system regulates APP metabolism/processing.
FEBS letters 2010;584(22):4611-8.
2010: Ana Martínez-García; Isabel Sastre; María Recuero; Jesús Aldudo; Elisabet Vilella; Ignacio Mateo; Pascual Sánchez-Juan; Teo Vargas; Eva Carro; Félix Bermejo-Pareja; Eloy Rodríguez-Rodríguez; Onofre Combarros; Marcel Rosich-Estrago; Ana Frank; Fernando Valdivieso; María J Bullido
PLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2010;22(4):1181-7.
2010: Eloy Rodríguez-Rodríguez; José Luis Vázquez-Higuera; Pascual Sánchez-Juan; Ignacio Mateo; Ana Pozueta; Ana Martínez-García; Ana Frank; Fernando Valdivieso; José Berciano; María J Bullido; Onofre Combarros
Epistasis between intracellular cholesterol trafficking-related genes (NPC1 and ABCA1) and Alzheimer's disease risk.
Journal of Alzheimer's disease : JAD 2010;21(2):619-25.
2010: José Luis Vázquez-Higuera; Eloy Rodríguez-Rodríguez; Pascual Sánchez-Juan; Ignacio Mateo; Ana Pozueta; Ana Martínez-García; Ana Frank; Fernando Valdivieso; José Berciano; María J Bullido; Onofre Combarros
Caspase-1 genetic variation is not associated with Alzheimer's disease risk.
BMC medical genetics 2010;11():32.
2009: Olga Calero; Rafael Hortigüela; María J Bullido; Miguel Calero
Apolipoprotein E genotyping method by real time PCR, a fast and cost-effective alternative to the TaqMan and FRET assays.
Journal of neuroscience methods 2009;183(2):238-40.
2009: María Recuero; María Carmen Vicente; Ana Martínez-García; María C Ramos; PEdro Carmona-Saez; Isabel Sastre; Jesús Aldudo; Elisabet Vilella; Ana Frank; María J Bullido; Fernando Valdivieso
A free radical-generating system induces the cholesterol biosynthesis pathway: a role in Alzheimer's disease.
Aging cell 2009;8(2):128-39.
2009: José Luis Vázquez-Higuera; Pascual Sánchez-Juan; Eloy Rodríguez-Rodríguez; Ignacio Mateo; Ana Pozueta; Ana Frank; Isabel Sastre; Fernando Valdivieso; José Berciano; María J Bullido; Onofre Combarros
DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort.
BMC medical genetics 2009;10():129.
2008: María J Bullido; Ana Martínez-García; Raquel Tenorio; Isabel Sastre; David G Muñoz; Ana Frank; Fernando Valdivieso
Double stranded RNA activated EIF2 alpha kinase (EIF2AK2; PKR) is associated with Alzheimer's disease.
Neurobiology of aging 2008;29(8):1160-6.
2008: Ana Martínez-García; Jesús Aldudo; María Recuero; Isabel Sastre; Elisabet Vilella-Cuadrada; Marcel Rosich-Estragó; Ana Frank; Fernando Valdivieso; María J Bullido
Presenilin 1 polymorphism associated with Alzheimer's disease in apolipoprotein E4 carriers.
Dementia and geriatric cognitive disorders 2008;26(5):440-4.
2007: María J Bullido; Ana Martínez-García; María J Artiga; Jesús Aldudo; Isabel Sastre; Pedro Gil; Francisco Coria; David G Muñoz; vladimir hachinski; Ana Frank; Fernando Valdivieso
A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers.
Neurobiology of aging 2007;28(4):519-23.
2006: María C Ramos; Raquel Tenorio; Ana Martínez-García; Isabel Sastre; Elisabet Vilella-Cuadrada; Ana Frank; Marcel Rosich-Estragó; Fernando Valdivieso; María J Bullido
Association of DSC1, a gene modulated by adrenergic stimulation, with Alzheimer's disease.
Neuroscience letters 2006;408(3):203-8.
2005: María C Ramos; Salomón Matías; María J Artiga; Julio Pozueta; Isabel Sastre; Fernando Valdivieso; María J Bullido
Neuronal specific regulatory elements in apolipoprotein E gene proximal promoter.
Neuroreport 2005;16(9):1027-30.
2004: Ana Martínez-García; Isabel Sastre; Raquel Tenorio; María J Bullido
SNP genotyping with FRET probes. Optimizing the resolution of heterozygotes.
Molecular and cellular probes 2004;18(4):211-4.
2004: María J Bullido; María C Ramos; Ana Ruiz-Gómez; Antonio S Tutor; Isabel Sastre; Ana Frank; Francisco Coria; Pedro Gil; Federico Mayor; Fernando Valdivieso
Polymorphism in genes involved in adrenergic signaling associated with Alzheimer's.
Neurobiology of aging 2004;25(7):853-9.
2004: María Recuero; Elena Serrano; María J Bullido; Fernando Valdivieso
Abeta production as consequence of cellular death of a human neuroblastoma overexpressing APP.
FEBS letters 2004;570(1-3):114-8.
2003: Javier S Burgos; Carlos Ramirez; Isabel Sastre; María J Bullido; Fernando Valdivieso
ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1.
Neuroreport 2003;14(14):1825-7.
2003: Mónica Campillos; José Ramón Lamas; Maria Angel García; María J Bullido; Fernando Valdivieso; Jesús Vázquez
Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity.
Nucleic acids research 2003;31(12):3063-70.
2002: Javier S Burgos; Carlos Ramirez; Isabel Sastre; María J Bullido; Fernando Valdivieso
Involvement of apolipoprotein E in the hematogenous route of herpes simplex virus type 1 to the central nervous system.
Journal of virology 2002;76(23):12394-8.
2002: A Frank; E Díez-Tejedor; María J Bullido; Fernando Valdivieso; P Barreiro
APOE genotype in cerebrovascular disease and vascular dementia.
Journal of the neurological sciences 2002;203-204():173-6.
2002: Javier S Burgos; C Ramírez; Raquel Tenorio; Isabel Sastre; María J Bullido
Influence of reagents formulation on real-time PCR parameters.
Molecular and cellular probes 2002;16(4):257-60.
2000: María J Bullido; Fernando Valdivieso
Apolipoprotein E gene promoter polymorphisms in Alzheimer's disease.
Microscopy research and technique 2000;50(4):261-7.
2000: María J Bullido; P Guallar-Castillón; María J Artiga; María C Ramos; Isabel Sastre; Jesús Aldudo; Ana Frank; Francisco Coria; F Rodríguez-Artalejo; Fernando Valdivieso
Alzheimer's risk associated with human apolipoprotein E, alpha-2 macroglobulin and lipoprotein receptor related protein polymorphisms: absence of genetic interactions, and modulation by gender.
Neuroscience letters 2000;289(3):213-6.
2000: María J Bullido; Jesús Aldudo; Ana Frank; Francisco Coria; Jesús Avila; Fernando Valdivieso
A polymorphism in the tau gene associated with risk for Alzheimer's disease.
Neuroscience letters 2000;278(1-2):49-52.
1999: L Chen; Larry Baum; Ho-Keung Ng; L Y Chan; Isabel Sastre; M J Artíga; Fernando Valdivieso; María J Bullido; Helen F K Chiu; C P Pang
Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease.
Neuroscience letters 1999;269(3):173-7.
1999: Jesús Aldudo; María J Bullido; Fernando Valdivieso
DGGE method for the mutational analysis of the coding and proximal promoter regions of the Alzheimer's disease presenilin-1 gene: two novel mutations.
Human mutation 1999;14(5):433-9.
1998: Gerwin Roks; Marc Cruts; María J Bullido; Hubert Backhovens; María J Artiga; Albert Hofman; Fernando Valdivieso; Christine Van Broeckhoven; C.M. Duijn
The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.
Neuroscience letters 1998;258(2):65-8.
1998: Jesús Aldudo; María J Bullido; A Frank; Fernando Valdivieso
Missense mutation E318G of the presenilin-1 gene appears to be a nonpathogenic polymorphism.
Annals of neurology 1998;44(6):985-6.
1998: María J Artiga; María J Bullido; Ana Frank; Isabel Sastre; María Recuero; Maria Angel García; C L Lendon; S W Han; John C Morris; Jesús Vázquez; Alison Goate; Fernando Valdivieso
Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.
Human molecular genetics 1998;7(12):1887-92.
1998: Jesús Aldudo; María J Bullido; T Arbizu; Rafael Oliva; Fernando Valdivieso
Identification of a novel mutation (Leu282Arg) of the human presenilin 1 gene in Alzheimer's disease.
Neuroscience letters 1998;240(3):174-6.
1998: María J Artiga; María J Bullido; Isabel Sastre; María Recuero; Maria Angel García; Jesús Aldudo; Jesús Vázquez; Fernando Valdivieso
Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene.
FEBS letters 1998;421(2):105-8.
1998: María J Bullido; María J Artiga; María Recuero; Isabel Sastre; Maria Angel García; Jesús Aldudo; C Lendon; S W Han; John C Morris; Ana Frank; Jesús Vázquez; Alison Goate; Fernando Valdivieso
A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.
Nature genetics 1998;18(1):69-71.
1997: C Haas; Jesús Aldudo; P Cazorla; María J Bullido; C de Miguel; Jesús Vázquez; Fernando Valdivieso
Proteolysis of Alzheimer's disease beta-amyloid precursor protein by factor Xa.
Biochimica et biophysica acta 1997;1343(1):85-94.
1996: I M Antón; S González; María J Bullido; M Corsín; Cristina Risco; J P Langeveld; Luis Enjuanes
Cooperation between transmissible gastroenteritis coronavirus (TGEV) structural proteins in the in vitro induction of virus-specific antibodies.
Virus research 1996;46(1-2):111-24.
1996: María J Bullido; M A Muñoz-Fernandez; María Recuero; Manuel Fresno; Fernando Valdivieso
Alzheimer's amyloid precursor protein is expressed on the surface of hematopoietic cells upon activation.
Biochimica et biophysica acta 1996;1313(1):54-62.
1995: P Cazorla; Jesús Aldudo; C Haas; Jesús Vázquez; Fernando Valdivieso; María J Bullido
Location of an epitope shared by Alzheimer's amyloid peptide and brain creatine kinase using a newly developed monoclonal antibody.
Biochimica et biophysica acta 1995;1270(2-3):149-56.
1990: C Suñé; G Jiménez; I Correa; María J Bullido; F Gebauer; C Smerdou; Luis Enjuanes
Mechanisms of transmissible gastroenteritis coronavirus neutralization.
Virology 1990;177(2):559-69.
1990: I Correa; F Gebauer; María J Bullido; C Suñé; Marc Baay; K A Zwaagstra; W P Posthumus; Johannes A Lenstra; Luis Enjuanes
Localization of antigenic sites of the E2 glycoprotein of transmissible gastroenteritis coronavirus.
The Journal of general virology 1990;71 ( Pt 2)():271-9.
1990: CP Sánchez; G Jiménez; M D Laviada; I Correa; C Suñé; María J Bullido; F Gebauer; C Smerdou; P Callebaut; José M Escribano
Antigenic homology among coronaviruses related to transmissible gastroenteritis virus.
Virology 1990;174(2):410-7.
1990: Luis Enjuanes; F Gebauer; I Correa; María J Bullido; C Suñé; C Smerdou; CP Sánchez; Johannes A Lenstra; W P Posthumus; Rob H Meloen
Location of antigenic sites of the S-glycoprotein of transmissible gastroenteritis virus and their conservation in coronaviruses.
Advances in experimental medicine and biology 1990;276():159-72.
1989: María J Bullido; I Correa; G Jiménez; C Suñé; F Gebauer; Luis Enjuanes
Induction of transmissible gastroenteritis coronavirus-neutralizing antibodies in vitro by virus-specific T helper cell hybridomas.
The Journal of general virology 1989;70 ( Pt 3)():659-72.
1988: I Correa; G Jiménez; C Suñé; María J Bullido; Luis Enjuanes
Antigenic structure of the E2 glycoprotein from transmissible gastroenteritis coronavirus.
Virus research 1988;10(1):77-93.
1987: Luis Enjuanes; I Correa; G Jiménez; M P Melgosa; María J Bullido
Critical epitopes in transmissible gastroenteritis virus neutralization.
Advances in experimental medicine and biology 1987;218():351-63.
1986: G Jiménez; I Correa; M P Melgosa; María J Bullido; Luis Enjuanes
Critical epitopes in transmissible gastroenteritis virus neutralization.
Journal of virology 1986;60(1):131-9.