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William Lederer

Research Profile

Chemicals & Drugs

Anatomy

Disorders

Myocardial Contraction

Living Beings

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Physiology

Calcium Signaling

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Publications

TOP 3
Liron Boyman; Daniel Khananshvili; Israel Sekler; George S B Williams; William Lederer
NCLX: The mitochondrial sodium calcium exchanger.
Benjamin Prosser; Christopher Ward; Andrew P Ziman; Ramzi J Khairallah; William Lederer
X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca(2+)]i.
Eric Sobie; William Lederer
Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.

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All Publications

2013: Liron Boyman; Daniel Khananshvili; Israel Sekler; George S B Williams; William Lederer
NCLX: The mitochondrial sodium calcium exchanger.
Journal of molecular and cellular cardiology 2013;59():205-13.
2013: Benjamin Prosser; Christopher Ward; Andrew P Ziman; Ramzi J Khairallah; William Lederer
X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca(2+)]i.
Journal of molecular and cellular cardiology 2013;58():172-81.
2012: Eric Sobie; William Lederer
Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.
Journal of molecular and cellular cardiology 2012;52(2):304-11.
2011: George S B Williams; Aristide C Chikando; William Lederer; Eric Sobie; Hoang-Trong M Tuan; M Saleet Jafri
Dynamics of calcium sparks and calcium leak in the heart.
Biophysical journal 2011;101(6):1287-96.
2011: Didier Brochet; Wenjun Xie; Dongmei Yang; Heping Cheng; William Lederer
Quarky calcium release in the heart.
Circulation research 2011;108(2):210-8.
2010: Mariah H Goodall; Robert D Wardlow; Rebecca R Goldblum; Andrew Ziman; William Lederer; William R Randall; Terry B Rogers
Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction.
The Journal of biological chemistry 2010;285(53):41686-700.
2010: Andrew P Ziman; Christopher Ward; George Rodney; William Lederer; Robert J Bloch
Quantitative measurement of Ca²(+) in the sarcoplasmic reticulum lumen of mammalian skeletal muscle.
Biophysical journal 2010;99(8):2705-14.
2010: Benjamin Prosser; Christopher Ward; William Lederer
Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity.
The Journal of general physiology 2010;136(2):135-42.
2010: Hena R Ramay; M Saleet Jafri; William Lederer; Eric Sobie
Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes.
Biophysical journal 2010;98(11):2515-23.
2010: Andrew P Ziman; Norma Leticia Gómez-Viquez; Robert J Bloch; William Lederer
Excitation-contraction coupling changes during postnatal cardiac development.
Journal of molecular and cellular cardiology 2010;48(2):379-86.
2009: N Lindegger; Brian Hagen; Andrew R Marks; William Lederer; Robert Kass
Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine.
Journal of molecular and cellular cardiology 2009;47(2):326-34.
2009: Dobromir Dobrev; Leyla Y Teos; William Lederer
Unique atrial myocyte Ca2+ signaling.
Journal of molecular and cellular cardiology 2009;46(4):448-51.
2009: Vadim V Salnikov; Y O Lukyanenko; William Lederer; Valeriy Lukyanenko
Distribution of ryanodine receptors in rat ventricular myocytes.
Journal of muscle research and cell motility 2009;30(3-4):161-70.
2008: Ralph J van Oort; Julio Altamirano; William Lederer; Xander H T Wehrens
Alternative splicing: a key mechanism for ankyrin-B functional diversity?
Journal of molecular and cellular cardiology 2008;45(6):709-11.
2008: Heping Cheng; William Lederer
Calcium sparks.
Physiological reviews 2008;88(4):1491-545.
2008: Thomas J Hund; Andrew P Ziman; William Lederer; Peter J Mohler
The cardiac IP3 receptor: uncovering the role of "the other" calcium-release channel.
Journal of molecular and cellular cardiology 2008;45(2):159-61.
2008: Silvia Guatimosim; Maria Jimena Amaya; Mateus T Guerra; Carla J Aguiar; Alfredo M Goes; Norma Leticia Gómez-Viquez; Michele Rodrigues; Dawidson Gomes; Juliana Martins-Cruz; William Lederer; M Fatima Leite
Nuclear Ca2+ regulates cardiomyocyte function.
Cell calcium 2008;44(2):230-42.
2008: Robert Kass; N Lindegger; Brian Hagen; William Lederer
Another calcium paradox in heart failure.
Journal of molecular and cellular cardiology 2008;45(1):28-31.
2008: Stephan Lehnart; Marco Mongillo; Andrew Bellinger; Nicolas Lindegger; Bi-Xing Chen; William Hsueh; Steven Reiken; Anetta Wronska; Liam J Drew; Christopher Ward; William Lederer; Robert Kass; Gregory Morley; Andrew R Marks
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.
The Journal of clinical investigation 2008;118(6):2230-45.
2008: Manuel F Navedo; Madeline Nieves-Cintrón; Gregory C Amberg; Can Yuan; V Scott Votaw; William Lederer; G Stanley McKnight; Luis F Santana
AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension.
Circulation research 2008;102(2):e1-e11.
2007: Stephan Lehnart; Michael J Ackerman; D Woodrow Benson; Ramon Brugada; colleen clancy; J Kevin Donahue; Alfred L George; Augustus O Grant; Stephen C Groft; Craig T January; David Austin Lathrop; William Lederer; Jonathan C Makielski; Peter J Mohler; Arthur Moss; Jeanne M Nerbonne; Timothy M Olson; DA Przywara; Jeffrey A Towbin; Lan-Hsiang Wang; Andrew R Marks
Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function.
Circulation 2007;116(20):2325-45.
2007: V Lukyanenko; Andrew P Ziman; A Lukyanenko; Vadim V Salnikov; William Lederer
Functional groups of ryanodine receptors in rat ventricular cells.
The Journal of physiology 2007;583(Pt 1):251-69.
2007: Sandor Györke; Brian Hagen; Dmitry Terentyev; William Lederer
Chain-reaction Ca(2+) signaling in the heart.
The Journal of clinical investigation 2007;117(7):1758-62.
2007: Eric Sobie; Joseph Kao; William Lederer
Novel approach to real-time flash photolysis and confocal [Ca2+] imaging.
Pflügers Archiv : European journal of physiology 2007;454(4):663-73.
2007: Abdul M Ruknudin; Shao-kui Wei; Mark C P Haigney; William Lederer; Dan H Schulze
Phosphorylation and other conundrums of Na/Ca exchanger, NCX1.
Annals of the New York Academy of Sciences 2007;1099():103-18.
2007: Vadim V Salnikov; Y O Lukyánenko; C A Frederick; William Lederer; V Lukyánenko
Probing the outer mitochondrial membrane in cardiac mitochondria with nanoparticles.
Biophysical journal 2007;92(3):1058-71.
2006: Stephan Lehnart; Cecile Terrenoire; Steven Reiken; Xander H T Wehrens; Long-Sheng Song; Erik J Tillman; Salvatore Mancarella; James Coromilas; William Lederer; Robert Kass; Andrew R Marks
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7906-10.
2006: Eric Sobie; Long-Sheng Song; William Lederer
Restitution of Ca(2+) release and vulnerability to arrhythmias.
Journal of cardiovascular electrophysiology 2006;17 Suppl 1():S64-S70.
2006: Long-Sheng Song; Eric Sobie; Stacey L McCulle; William Lederer; C William Balke; Heping Cheng
Orphaned ryanodine receptors in the failing heart.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4305-10.
2006: Ira R Josephson; William Lederer; Hali A Hartmann
Letter regarding article by Darbar et al, "unmasking of Brugada syndrome by lithium".
Circulation 2006;113(10):e408; author reply e408.
2006: Alexander S Parfenov; Vadim V Salnikov; William Lederer; V Lukyánenko
Aqueous diffusion pathways as a part of the ventricular cell ultrastructure.
Biophysical journal 2006;90(3):1107-19.
2006: Eric Sobie; Silvia Guatimosim; Leticia Gómez-Viquez; Long-Sheng Song; Hali Hartmann; M Saleet Jafri; William Lederer
The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice.
Progress in biophysics and molecular biology 2006;90(1-3):172-85.
2005: Long-Sheng Song; YeQing Pi; Song-Jung Kim; Atsuko Yatani; Silvia Guatimosim; Raymond K Kudej; Qingxiu Zhang; Heping Cheng; Luc Hittinger; Bijan Ghaleh; Dorothy E Vatner; William Lederer; Stephen F Vatner
Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy.
Circulation research 2005;97(5):457-64.
2005: Luis F Santana; Harol Núñez-Durán; Keith Dilly; William Lederer
Sodium current and arrhythmogenesis in heart failure.
Heart failure clinics 2005;1(2):193-205.
2005: Long-Sheng Song; Silvia Guatimosim; Leticia Gómez-Viquez; Eric Sobie; Andrew P Ziman; Hali Hartmann; William Lederer
Calcium biology of the transverse tubules in heart.
Annals of the New York Academy of Sciences 2005;1047():99-111.
2005: Eric Sobie; Long-Sheng Song; William Lederer
Local recovery of Ca2+ release in rat ventricular myocytes.
The Journal of physiology 2005;565(Pt 2):441-7.
2005: Christopher Ward; William Lederer
Ghost sparks.
Nature cell biology 2005;7(5):457-9.
2005: Harry Knot; Ismail Laher; Eric Sobie; Silvia Guatimosim; Leticia Gomez-Viquez; Hali Hartmann; Long-Sheng Song; William Lederer; Wolfgang F. Graier; Roland Malli; Maud Frieden; Ole H Petersen
Twenty years of calcium imaging: cell physiology to dye for.
Molecular interventions 2005;5(2):112-27.
2005: Rong Zhang; Michelle S C Khoo; Yuejin Wu; Yingbo Yang; Chad E Grueter; Gemin Ni; Edward E Price; William Thiel; Silvia Guatimosim; Long-Sheng Song; Ernest Madu; Anisha N Shah; Tatiana A Vishnivetskaya; James B Atkinson; Vsevolod V Gurevich; Guy Salama; William Lederer; Roger J Colbran; Mark E Anderson
Calmodulin kinase II inhibition protects against structural heart disease.
Nature medicine 2005;11(4):409-17.
2005: Didier Brochet; Dongmei Yang; Alessandro Di Maio; William Lederer; Clara Franzini-Armstrong; Heping Cheng
Ca2+ blinks: rapid nanoscopic store calcium signaling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3099-104.
2004: Keith Dilly; Junko Kurokawa; Cecile Terrenoire; Steven Reiken; William Lederer; Andrew R Marks; Robert Kass
Overexpression of beta2-adrenergic receptors cAMP-dependent protein kinase phosphorylates and modulates slow delayed rectifier potassium channels expressed in murine heart: evidence for receptor/channel co-localization.
The Journal of biological chemistry 2004;279(39):40778-87.
2003: Dan H Schulze; Muqeem Muqhal; William Lederer; Abdul M Ruknudin
Sodium/calcium exchanger (NCX1) macromolecular complex.
The Journal of biological chemistry 2003;278(31):28849-55.
2003: Xander H T Wehrens; Stephan Lehnart; Fannie Huang; John A Vest; Steven Reiken; Peter J Mohler; Jie Sun; Silvia Guatimosim; Long-Sheng Song; Nora Rosemblit; Jeanine D'Armiento; Carlo Napolitano; Mirella Memmi; silvia priori; William Lederer; Andrew R Marks
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.
Cell 2003;113(7):829-40.
2003: Eric Sobie; Silvia Guatimosim; Long-Sheng Song; William Lederer
The challenge of molecular medicine: complexity versus Occam's razor.
The Journal of clinical investigation 2003;111(6):801-3.
2003: Peter J Mohler; Jean-Jacques Schott; Anthony O Gramolini; Keith Dilly; Silvia Guatimosim; William H duBell; Long-Sheng Song; Karine Haurogné; Florence Kyndt; Mervat E Ali; Terry B Rogers; William Lederer; Denis Escande; Hervé Le Marec; Vann Bennett
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death.
Nature 2003;421(6923):634-9.
2003: Steven Reiken; Marta Gaburjakova; Silvia Guatimosim; Ana Gomez; Jeanine D'Armiento; Daniel Burkhoff; Jie Wang; Guy Vassort; William Lederer; Andrew R Marks
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol.
The Journal of biological chemistry 2003;278(1):444-53.
2002: Kin M Choi; Yan Zhong; Brian D Hoit; Ingrid L Grupp; Harvey Hahn; Keith Dilly; Silvia Guatimosim; William Lederer; Mohammed A Matlib
Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1398-408.
2002: Silvia Guatimosim; Keith Dilly; Luis F Santana; M Saleet Jafri; Eric Sobie; William Lederer
Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient.
Journal of molecular and cellular cardiology 2002;34(8):941-50.
2002: Eric Sobie; Keith Dilly; Jader dos Santos Cruz; William Lederer; M Saleet Jafri
Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.
Biophysical journal 2002;83(1):59-78.
2002: William H duBell; Marisa S Gigena; Silvia Guatimosim; Xilin Long; William Lederer; Terry B Rogers
Effects of PP1/PP2A inhibitor calyculin A on the E-C coupling cascade in murine ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2002;282(1):H38-48.
2001: George C Wellman; L Cartin; Delrae M Eckman; Andra S Stevenson; Christine M Saundry; William Lederer; Mark T Nelson
Membrane depolarization, elevated Ca(2+) entry, and gene expression in cerebral arteries of hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2559-67.
2001: Ana Gomez; Silvia Guatimosim; Keith Dilly; Guy Vassort; William Lederer
Heart failure after myocardial infarction: altered excitation-contraction coupling.
Circulation 2001;104(6):688-93.
2001: Carmen A Ufret-Vincenty; Deborah J Baro; William Lederer; H A Rockman; L E Quinones; Luis F Santana
Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure.
The Journal of biological chemistry 2001;276(30):28197-203.
2001: Silvia Guatimosim; Eric Sobie; Jader dos Santos Cruz; L A Martin; William Lederer
Molecular identification of a TTX-sensitive Ca(2+) current.
American journal of physiology. Cell physiology 2001;280(5):C1327-39.
2000: Abdul M Ruknudin; S He; William Lederer; Dan H Schulze
Functional differences between cardiac and renal isoforms of the rat Na+-Ca2+ exchanger NCX1 expressed in Xenopus oocytes.
The Journal of physiology 2000;529 Pt 3():599-610.
2000: Giovanni Esposito; Luis F Santana; Keith Dilly; J D Cruz; Lan Mao; William Lederer; Howard A Rockman
Cellular and functional defects in a mouse model of heart failure.
American journal of physiology. Heart and circulatory physiology 2000;279(6):H3101-12.
2000: William H duBell; William Lederer; Terry B Rogers
K(+) currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and rapamycin.
American journal of physiology. Heart and circulatory physiology 2000;278(3):H886-97.
2000: Jonathan H Jaggar; VA Porter; William Lederer; Mark T Nelson
Calcium sparks in smooth muscle.
American journal of physiology. Cell physiology 2000;278(2):C235-56.
1999: Mordecai P Blaustein; William Lederer
Sodium/calcium exchange: its physiological implications.
Physiological reviews 1999;79(3):763-854.
1999: Marcel Egger; Abdul M Ruknudin; Ernst Niggli; William Lederer; Dan H Schulze
Ni2+ transport by the human Na+/Ca2+ exchanger expressed in Sf9 cells.
The American journal of physiology 1999;276(5 Pt 1):C1184-92.
1999: Marcel Egger; Abdul M Ruknudin; Peter Lipp; P Kofuji; William Lederer; Dan H Schulze; Ernst Niggli
Functional expression of the human cardiac Na+/Ca2+ exchanger in Sf9 cells: rapid and specific Ni2+ transport.
Cell calcium 1999;25(1):9-17.
1998: Jonathan H Jaggar; George C Wellman; Thomas J Heppner; VA Porter; G J Perez; M Gollasch; T Kleppisch; M Rubart; Andra S Stevenson; William Lederer; Harry Knot; Adrian D Bonev; Mark T Nelson
Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone.
Acta physiologica Scandinavica 1998;164(4):577-87.
1998: William H duBell; S T Gaa; William Lederer; Terry B Rogers
Independent inhibition of calcineurin and K+ currents by the immunosuppressant FK-506 in rat ventricle.
The American journal of physiology 1998;275(6 Pt 2):H2041-52.
1998: GA Drago; John Colyer; William Lederer
Immunofluorescence localization of SERCA2a and the phosphorylated forms of phospholamban in intact rat cardiac ventricular myocytes.
Annals of the New York Academy of Sciences 1998;853():273-9.
1998: G D Smith; Joel Keizer; M D Stern; William Lederer; Heping Cheng
A simple numerical model of calcium spark formation and detection in cardiac myocytes.
Biophysical journal 1998;75(1):15-32.
1998: S He; Abdul M Ruknudin; Linda L Bambrick; William Lederer; Dan H Schulze
Isoform-specific regulation of the Na+/Ca2+ exchanger in rat astrocytes and neurons by PKA.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(13):4833-41.
1998: Abdul M Ruknudin; Dan H Schulze; S K Sullivan; William Lederer; Fang Liang
Novel subunit composition of a renal epithelial KATP channel.
The Journal of biological chemistry 1998;273(23):14165-71.
1998: VA Porter; Adrian D Bonev; Harry Knot; Thomas J Heppner; Andra S Stevenson; T Kleppisch; William Lederer; Mark T Nelson
Frequency modulation of Ca2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides.
The American journal of physiology 1998;274(5 Pt 1):C1346-55.
1998: Luis F Santana; Ana Gomez; William Lederer
Ca2+ flux through promiscuous cardiac Na+ channels: slip-mode conductance.
Science (New York, N.Y.) 1998;279(5353):1027-33.
1998: R M Phillips; P Narayan; Ana Gomez; Keith Dilly; L R Jones; William Lederer; Ruth A Altschuld
Sarcoplasmic reticulum in heart failure: central player or bystander?
Cardiovascular research 1998;37(2):346-51.
1997: Luis F Santana; E G Kranias; William Lederer
Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes.
The Journal of physiology 1997;503 ( Pt 1)():21-9.
1997: Abdul M Ruknudin; C Valdivia; P Kofuji; William Lederer; Dan H Schulze
Na+/Ca2+ exchanger in Drosophila: cloning, expression, and transport differences.
The American journal of physiology 1997;273(1 Pt 1):C257-65.
1997: William H duBell; P A Wright; William Lederer; Terry B Rogers
Effect of the immunosupressant FK506 on excitation-contraction coupling and outward K+ currents in rat ventricular myocytes.
The Journal of physiology 1997;501 ( Pt 3)():509-16.
1997: Ana Gomez; Héctor H Valdivia; Heping Cheng; M R Lederer; Luis F Santana; Mark Cannell; Sylvia A McCune; Ruth A Altschuld; William Lederer
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.
Science (New York, N.Y.) 1997;276(5313):800-6.
1997: Jean-Pierre Benitah; Ana Gomez; Carmen Delgado; P Lorente; William Lederer
A chloride current component induced by hypertrophy in rat ventricular myocytes.
The American journal of physiology 1997;272(5 Pt 2):H2500-6.
1997: Yong-Fu Xiao; Ana Gomez; James P Morgan; William Lederer; Alexander Leaf
Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):4182-7.
1997: Z Li; Heping Cheng; William Lederer; James B Froehlich; Edward G Lakatta
Enhanced proliferation and migration and altered cytoskeletal proteins in early passage smooth muscle cells from young and old rat aortic explants.
Experimental and molecular pathology 1997;64(1):1-11.
1997: Luis F Santana; Ana Gomez; E G Kranias; William Lederer
Amount of calcium in the sarcoplasmic reticulum: influence on excitation-contraction coupling in heart muscle.
Heart and vessels 1997;Suppl 12():44-9.
1996: Alain Lacampagne; William Lederer; Martin F Schneider; Michael G Klein
Repriming and activation alter the frequency of stereotyped discrete Ca2+ release events in frog skeletal muscle.
The Journal of physiology 1996;497 ( Pt 3)():581-8.
1996: Ana Gomez; Heping Cheng; William Lederer; Donald M Bers
Ca2+ diffusion and sarcoplasmic reticulum transport both contribute to [Ca2+]i decline during Ca2+ sparks in rat ventricular myocytes.
The Journal of physiology 1996;496 ( Pt 2)():575-81.
1996: Heping Cheng; M R Lederer; Rui-Ping Xiao; Ana Gomez; Ying-Ying Zhou; Bruce D Ziman; Harold A Spurgeon; Edward G Lakatta; William Lederer
Excitation-contraction coupling in heart: new insights from Ca2+ sparks.
Cell calcium 1996;20(2):129-40.
1996: William H duBell; William Lederer; Terry B Rogers
Dynamic modulation of excitation-contraction coupling by protein phosphatases in rat ventricular myocytes.
The Journal of physiology 1996;493 ( Pt 3)():793-800.
1996: T A Kohout; J J O'Brian; S T Gaa; William Lederer; Terry B Rogers
Novel adenovirus component system that transfects cultured cardiac cells with high efficiency.
Circulation research 1996;78(6):971-7.
1996: William Lederer; S He; S Luo; William H duBell; P Kofuji; R Kieval; C F Neubauer; Abdul M Ruknudin; Heping Cheng; Mark Cannell; Terry B Rogers; Dan H Schulze
The molecular biology of the Na(+)-Ca2+ exchanger and its functional roles in heart, smooth muscle cells, neurons, glia, lymphocytes, and nonexcitable cells.
Annals of the New York Academy of Sciences 1996;779():7-17.
1996: Dan H Schulze; P Kofuji; C Valdivia; S He; S Luo; Abdul M Ruknudin; S Wisel; M S Kirby; William H duBell; William Lederer
Alternative splicing of the Na(+)-Ca2+ exchanger gene, NCX1.
Annals of the New York Academy of Sciences 1996;779():46-57.
1996: A E Doering; D A Eisner; William Lederer
Cardiac Na-Ca exchange and pH.
Annals of the New York Academy of Sciences 1996;779():182-98.
1996: Michael G Klein; Heping Cheng; Luis F Santana; Y H Jiang; William Lederer; Martin F Schneider
Two mechanisms of quantized calcium release in skeletal muscle.
Nature 1996;379(6564):455-8.
1996: Heping Cheng; M R Lederer; William Lederer; Mark Cannell
Calcium sparks and [Ca2+]i waves in cardiac myocytes.
The American journal of physiology 1996;270(1 Pt 1):C148-59.
1996: Luis F Santana; Heping Cheng; Ana Gomez; Mark Cannell; William Lederer
Relation between the sarcolemmal Ca2+ current and Ca2+ sparks and local control theories for cardiac excitation-contraction coupling.
Circulation research 1996;78(1):166-71.
1995: Robert W Hadley; William Lederer
Nifedipine inhibits movement of cardiac calcium channels through late, but not early, gating transitions.
The American journal of physiology 1995;269(5 Pt 2):H1784-90.
1995: Mark T Nelson; Heping Cheng; M Rubart; L F Santana; Adrian D Bonev; Harry Knot; William Lederer
Relaxation of arterial smooth muscle by calcium sparks.
Science (New York, N.Y.) 1995;270(5236):633-7.
1995: Terry B Rogers; Giuseppe Inesi; R Wade; William Lederer
Use of thapsigargin to study Ca2+ homeostasis in cardiac cells.
Bioscience reports 1995;15(5):341-9.
1995: Andrew J Lokuta; Terry B Rogers; William Lederer; Héctor H Valdivia
Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation-dephosphorylation mechanism.
The Journal of physiology 1995;487 ( Pt 3)():609-22.
1995: Mark Cannell; Heping Cheng; William Lederer
The control of calcium release in heart muscle.
Science (New York, N.Y.) 1995;268(5213):1045-9.
1995: Heping Cheng; M Fill; H Valdivia; William Lederer
Models of Ca2+ release channel adaptation.
Science (New York, N.Y.) 1995;267(5206):2009-10.
1995: Héctor H Valdivia; Jack H Kaplan; G C Ellis-Davies; William Lederer
Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation.
Science (New York, N.Y.) 1995;267(5206):1997-2000.
1995: Heping Cheng; Mark Cannell; William Lederer
Partial inhibition of Ca2+ current by methoxyverapamil (D600) reveals spatial nonuniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes.
Circulation research 1995;76(2):236-41.
1994: Mark Cannell; Heping Cheng; William Lederer
Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes.
Biophysical journal 1994;67(5):1942-56.
1994: A E Doering; William Lederer
The action of Na+ as a cofactor in the inhibition by cytoplasmic protons of the cardiac Na(+)-Ca2+ exchanger in the guinea-pig.
The Journal of physiology 1994;480 ( Pt 1)():9-20.
1994: Heping Cheng; Mark Cannell; William Lederer
Propagation of excitation-contraction coupling into ventricular myocytes.
Pflügers Archiv : European journal of physiology 1994;428(3-4):415-7.
1994: R P Xiao; Heping Cheng; William Lederer; T Suzuki; Edward G Lakatta
Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9659-63.
1994: M S Kirby; R W Hadley; William Lederer
Measurement of intracellular Ca2+ concentration using Indo-1 during simultaneous flash photolysis to release Ca2+ from DM-nitrophen.
Pflügers Archiv : European journal of physiology 1994;427(1-2):169-77.
1994: P Kofuji; William Lederer; Dan H Schulze
Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger.
The Journal of biological chemistry 1994;269(7):5145-9.
1994: Ernst Niggli; D W Piston; M S Kirby; Heping Cheng; D R Sandison; W W Webb; William Lederer
A confocal laser scanning microscope designed for indicators with ultraviolet excitation wavelengths.
The American journal of physiology 1994;266(1 Pt 1):C303-10.
1994: Andrew J Lokuta; M S Kirby; S T Gaa; William Lederer; Terry B Rogers
On establishing primary cultures of neonatal rat ventricular myocytes for analysis over long periods.
Journal of cardiovascular electrophysiology 1994;5(1):50-62.
1994: Joseph R Lakowicz; Henryk Szmacinski; Kazimierz Nowaczyk; William Lederer; M S Kirby; M L Johnson
Fluorescence lifetime imaging of intracellular calcium in COS cells using Quin-2.
Cell calcium 1994;15(1):7-27.
1993: R W Hadley; M S Kirby; William Lederer; Joseph Kao
Does the use of DM-nitrophen, nitr-5, or diazo-2 interfere with the measurement of indo-1 fluorescence?
Biophysical journal 1993;65(6):2537-46.
1993: Heping Cheng; William Lederer; Mark Cannell
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle.
Science (New York, N.Y.) 1993;262(5134):740-4.
1993: Dan H Schulze; P Kofuji; R Hadley; M S Kirby; R S Kieval; A Doering; Ernst Niggli; William Lederer
Sodium/calcium exchanger in heart muscle: molecular biology, cellular function, and its special role in excitation-contraction coupling.
Cardiovascular research 1993;27(10):1726-34.
1993: P Kofuji; William Lederer; Dan H Schulze
Na/Ca exchanger isoforms expressed in kidney.
The American journal of physiology 1993;265(4 Pt 2):F598-603.
1993: N M Cohen; William Lederer
Calcium current in single human cardiac myocytes.
Journal of cardiovascular electrophysiology 1993;4(4):422-37.
1993: Ernst Niggli; William Lederer
Activation of Na-Ca exchange current by photolysis of "caged calcium".
Biophysical journal 1993;65(2):882-91.
1993: A E Doering; William Lederer
The mechanism by which cytoplasmic protons inhibit the sodium-calcium exchanger in guinea-pig heart cells.
The Journal of physiology 1993;466():481-99.
1993: K Ho; Colin G Nichols; William Lederer; Jonathan Lytton; Peter M Vassilev; Marie Kanazirska; S C Hebert
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.
Nature 1993;362(6415):31-8.
1993: C Ripoll; William Lederer; C G Nichols
On the mechanism of inhibition of KATP channels by glibenclamide in rat ventricular myocytes.
Journal of cardiovascular electrophysiology 1993;4(1):38-47.
1993: Lisa D McDaniel; William Lederer; P Kofuji; Dan H Schulze; R Kieval; Roger A Schultz
Mapping of the human cardiac Na+/Ca2+ exchanger gene (NCX1) by fluorescent in situ hybridization to chromosome region 2p22-->p23.
Cytogenetics and cell genetics 1993;63(3):192-3.
1992: Héctor H Valdivia; M S Kirby; William Lederer; Roberto Coronado
Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12185-9.
1992: P Kofuji; R W Hadley; R S Kieval; William Lederer; Dan H Schulze
Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger.
The American journal of physiology 1992;263(6 Pt 1):C1241-9.
1992: R S Kieval; Robert J Bloch; G E Lindenmayer; A Ambesi; William Lederer
Immunofluorescence localization of the Na-Ca exchanger in heart cells.
The American journal of physiology 1992;263(2 Pt 1):C545-50.
1992: M S Kirby; Y Sagara; S Gaa; Giuseppe Inesi; William Lederer; Terry B Rogers
Thapsigargin inhibits contraction and Ca2+ transient in cardiac cells by specific inhibition of the sarcoplasmic reticulum Ca2+ pump.
The Journal of biological chemistry 1992;267(18):12545-51.
1992: R W Hadley; William Lederer
Comparison of the effects of BAY K 8644 on cardiac Ca2+ current and Ca2+ channel gating current.
The American journal of physiology 1992;262(2 Pt 2):H472-7.
1991: C G Nichols; William Lederer
Adenosine triphosphate-sensitive potassium channels in the cardiovascular system.
The American journal of physiology 1991;261(6 Pt 2):H1675-86.
1991: R W Hadley; William Lederer
Ca2+ and voltage inactivate Ca2+ channels in guinea-pig ventricular myocytes through independent mechanisms.
The Journal of physiology 1991;444():257-68.
1991: C V Massey; T A Kohout; S T Gaa; William Lederer; Terry B Rogers
Molecular and cellular actions of platelet-activating factor in rat heart cells.
The Journal of clinical investigation 1991;88(6):2106-16.
1991: C G Nichols; William Lederer; Mark Cannell
ATP dependence of KATP channel kinetics in isolated membrane patches from rat ventricle.
Biophysical journal 1991;60(5):1164-77.
1991: M M Abdellatif; C F Neubauer; William Lederer; Terry B Rogers
Angiotensin-induced desensitization of the phosphoinositide pathway in cardiac cells occurs at the level of the receptor.
Circulation research 1991;69(3):800-9.
1991: R W Hadley; William Lederer
Properties of L-type calcium channel gating current in isolated guinea pig ventricular myocytes.
The Journal of general physiology 1991;98(2):265-85.
1991: Ernst Niggli; William Lederer
Restoring forces in cardiac myocytes. Insight from relaxations induced by photolysis of caged ATP.
Biophysical journal 1991;59(5):1123-35.
1991: C G Nichols; William Lederer
The mechanism of KATP channel inhibition by ATP.
The Journal of general physiology 1991;97(5):1095-8.
1991: Ernst Niggli; William Lederer
Molecular operations of the sodium-calcium exchanger revealed by conformation currents.
Nature 1991;349(6310):621-4.
1991: C G Nichols; C Ripoll; William Lederer
ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction.
Circulation research 1991;68(1):280-7.
1991: Ernst Niggli; William Lederer
Photorelease of Ca2+ produces Na-Ca exchange currents and Na-Ca exchange "gating" currents.
Annals of the New York Academy of Sciences 1991;639():61-70.
1991: A E Doering; William Lederer
Voltage-dependent block of the Na-Ca exchanger in heart muscle examined using giant excised patches from guinea pig cardiac myocytes.
Annals of the New York Academy of Sciences 1991;639():172-6.
1990: C Ripoll; William Lederer; C G Nichols
Modulation of ATP-sensitive K+ channel activity and contractile behavior in mammalian ventricle by the potassium channel openers cromakalim and RP49356.
The Journal of pharmacology and experimental therapeutics 1990;255(2):429-35.
1990: Ernst Niggli; William Lederer
Voltage-independent calcium release in heart muscle.
Science (New York, N.Y.) 1990;250(4980):565-8.
1990: J R Berlin; Marcella A Wozniak; Mark Cannell; Robert J Bloch; William Lederer
Measurement of intracellular Ca2+ in BC3H-1 muscle cells with Fura-2: relationship to acetylcholine receptor synthesis.
Cell calcium 1990;11(5):371-84.
1990: Donald M Bers; William Lederer; J R Berlin
Intracellular Ca transients in rat cardiac myocytes: role of Na-Ca exchange in excitation-contraction coupling.
The American journal of physiology 1990;258(5 Pt 1):C944-54.
1990: William Lederer; Ernst Niggli; R W Hadley
Sodium-calcium exchange in excitable cells: fuzzy space.
Science (New York, N.Y.) 1990;248(4953):283.
1990: C G Nichols; William Lederer
The regulation of ATP-sensitive K+ channel activity in intact and permeabilized rat ventricular myocytes.
The Journal of physiology 1990;423():91-110.
1990: Ernst Niggli; William Lederer
Real-time confocal microscopy and calcium measurements in heart muscle cells: towards the development of a fluorescence microscope with high temporal and spatial resolution.
Cell calcium 1990;11(2-3):121-30.
1990: C G Nichols; William Lederer
The role of ATP in energy-deprivation contractures in unloaded rat ventricular myocytes.
Canadian journal of physiology and pharmacology 1990;68(2):183-94.
1990: William Lederer; J R Berlin; N M Cohen; R W Hadley; Donald M Bers; Mark Cannell
Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum.
Annals of the New York Academy of Sciences 1990;588():190-206.
1990: C G Nichols; Ernst Niggli; William Lederer
Modulation of ATP-sensitive potassium channel activity by flash-photolysis of 'caged-ATP' in rat heart cells.
Pflügers Archiv : European journal of physiology 1990;415(4):510-2.
1989: Mark Cannell; J R Berlin; William Lederer
Does voltage affect excitation-contraction coupling in the heart?
Science (New York, N.Y.) 1989;246(4937):1640.
1989: William Lederer; C G Nichols
Nucleotide modulation of the activity of rat heart ATP-sensitive K+ channels in isolated membrane patches.
The Journal of physiology 1989;419():193-211.
1989: William Lederer; Mark Cannell; N M Cohen; J R Berlin
Excitation-contraction coupling in heart muscle.
Molecular and cellular biochemistry 1989;89(2):115-9.
1989: R W Hadley; William Lederer
Intramembrane charge movement in guinea-pig and rat ventricular myocytes.
The Journal of physiology 1989;415():601-24.
1989: J R Berlin; Mark Cannell; William Lederer
Cellular origins of the transient inward current in cardiac myocytes. Role of fluctuations and waves of elevated intracellular calcium.
Circulation research 1989;65(1):115-26.
1989: William Lederer; C G Nichols; G L Smith
The mechanism of early contractile failure of isolated rat ventricular myocytes subjected to complete metabolic inhibition.
The Journal of physiology 1989;413():329-49.
1988: N M Cohen; William Lederer
Changes in the calcium current of rat heart ventricular myocytes during development.
The Journal of physiology 1988;406():115-46.
1988: Michael D Stern; HS Silverman; Steven R Houser; R A Josephson; Maurizio C Capogrossi; C G Nichols; William Lederer; Edward G Lakatta
Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6954-8.
1988: I S Allen; N M Cohen; R S Dhallan; S T Gaa; William Lederer; Terry B Rogers
Angiotensin II increases spontaneous contractile frequency and stimulates calcium current in cultured neonatal rat heart myocytes: insights into the underlying biochemical mechanisms.
Circulation research 1988;62(3):524-34.
1988: A Döşemeci; R S Dhallan; N M Cohen; William Lederer; Terry B Rogers
Phorbol ester increases calcium current and simulates the effects of angiotensin II on cultured neonatal rat heart myocytes.
Circulation research 1988;62(2):347-57.
1987: Mark Cannell; J R Berlin; William Lederer
Effect of membrane potential changes on the calcium transient in single rat cardiac muscle cells.
Science (New York, N.Y.) 1987;238(4832):1419-23.
1987: J R Berlin; Mark Cannell; William Lederer
Regulation of twitch tension in sheep cardiac Purkinje fibers during calcium overload.
The American journal of physiology 1987;253(6 Pt 2):H1540-7.
1987: N M Cohen; William Lederer
Calcium current in isolated neonatal rat ventricular myocytes.
The Journal of physiology 1987;391():169-91.
1987: R D Vaughan-Jones; D A Eisner; William Lederer
Effects of changes of intracellular pH on contraction in sheep cardiac Purkinje fibers.
The Journal of general physiology 1987;89(6):1015-32.
1987: Withrow Wier; Mark Cannell; J R Berlin; Eduardo Marban; William Lederer
Cellular and subcellular heterogeneity of [Ca2+]i in single heart cells revealed by fura-2.
Science (New York, N.Y.) 1987;235(4786):325-8.
1987: Mark Cannell; J R Berlin; William Lederer
Intracellular calcium in cardiac myocytes: calcium transients measured using fluorescence imaging.
Society of General Physiologists series 1987;42():201-14.
1986: Mark Cannell; D A Eisner; William Lederer; M Valdeolmillos
Effects of membrane potential on intracellular calcium concentration in sheep Purkinje fibres in sodium-free solutions.
The Journal of physiology 1986;381():193-203.
1986: Mark Cannell; William Lederer
The arrhythmogenic current ITI in the absence of electrogenic sodium-calcium exchange in sheep cardiac Purkinje fibres.
The Journal of physiology 1986;374():201-19.
1986: Mark Cannell; William Lederer
A novel experimental chamber for single-cell voltage-clamp and patch-clamp applications with low electrical noise and excellent temperature and flow control.
Pflügers Archiv : European journal of physiology 1986;406(5):536-9.
1985: Mark Cannell; R D Vaughan-Jones; William Lederer
Ryanodine block of calcium oscillations in heart muscle and the sodium-tension relationship.
Federation proceedings 1985;44(15):2964-9.
1985: S S Sheu; William Lederer
Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity.
Circulation research 1985;57(4):578-90.
1985: D A Eisner; William Lederer
Na-Ca exchange: stoichiometry and electrogenicity.
The American journal of physiology 1985;248(3 Pt 1):C189-202.
1985: R D Vaughan-Jones; D A Eisner; William Lederer
The effects of intracellular Na on contraction and intracellular pH in mammalian cardiac muscle.
Advances in myocardiology 1985;5():313-30.
1984: D A Eisner; William Lederer; R D Vaughan-Jones
The quantitative relationship between twitch tension and intracellular sodium activity in sheep cardiac Purkinje fibres.
The Journal of physiology 1984;355():251-66.
1984: William Lederer; M T Nelson
Sodium pump stoicheiometry determined by simultaneous measurements of sodium efflux and membrane current in barnacle.
The Journal of physiology 1984;348():665-77.
1984: William Lederer; S S Sheu; R D Vaughan-Jones; D A Eisner
The effects of Na-Ca exchange on membrane currents in sheep cardiac Purkinje fibers.
Society of General Physiologists series 1984;38():373-80.
1984: M T Nelson; William Lederer
Sodium-dependent calcium efflux and sodium-dependent current in perfused barnacle muscle single cells.
Society of General Physiologists series 1984;38():365-71.
1984: D A Eisner; William Lederer; R D Vaughan-Jones
The electrogenic Na pump in mammalian cardiac muscle.
Society of General Physiologists series 1984;38():193-213.
1983: D A Eisner; R D Vaughan-Jones; William Lederer
Active transport and inotropic state in guinea pig left atrium.
Circulation research 1983;53(6):834-6.
1983: William Lederer
Piezoelectric translator. A simple and inexpensive device to move microelectrodes and micropipettes small distances rapidly.
Pflügers Archiv : European journal of physiology 1983;399(1):83-6.
1983: William Lederer; M T Nelson
Effects of extracellular sodium on calcium efflux and membrane current in single muscle cells from the barnacle.
The Journal of physiology 1983;341():325-39.
1983: D A Eisner; William Lederer; S S Sheu
The role of intracellular sodium activity in the anti-arrhythmic action of local anaesthetics in sheep Purkinje fibres.
The Journal of physiology 1983;340():239-57.
1983: R D Vaughan-Jones; William Lederer; D A Eisner
Ca2+ ions can affect intracellular pH in mammalian cardiac muscle.
Nature 1983;301(5900):522-4.
1983: D A Eisner; William Lederer; R D Vaughan-Jones
The control of tonic tension by membrane potential and intracellular sodium activity in the sheep cardiac Purkinje fibre.
The Journal of physiology 1983;335():723-43.
1982: William Lederer; D A Eisner
The effects of sodium pump activity on the slow inward current in sheep cardiac Purkinje fibres.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1982;214(1195):249-62.
1981: D A Eisner; William Lederer; R D Vaughan-Jones
The effects of rubidium ions and membrane potentials on the intracellular sodium activity of sheep Purkinje fibres.
The Journal of physiology 1981;317():189-205.
1981: D A Eisner; William Lederer; R D Vaughan-Jones
The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep Purkinje fibres.
The Journal of physiology 1981;317():163-87.
1980: D A Eisner; William Lederer
The relationship between sodium pump activity and twitch tension in cardiac Purkinje fibres.
The Journal of physiology 1980;303():475-94.
1980: D A Eisner; William Lederer
Characterization of the electrogenic sodium pump in cardiac Purkinje fibres.
The Journal of physiology 1980;303():441-74.
1979: D A Eisner; William Lederer
Does sodium pump inhibition produce the positive inotropic effects of strophanthidine in mammalian cardiac muscle? [proceedings].
The Journal of physiology 1979;296():75P-76P.
1979: D A Eisner; William Lederer
A cellular basis for lidocaine's anti-arrhythmic action [proceedings].
The Journal of physiology 1979;295():25P-26P.
1979: William Lederer; A J Spindler; D A Eisner
Thick slurry bevelling: a new technique for bevelling extremely fine microelectrodes and micropipettes.
Pflügers Archiv : European journal of physiology 1979;381(3):287-8.
1979: D A Eisner; William Lederer
The role of the sodium pump in the effects of potassium-depleted solutions on mammalian cardiac muscle.
The Journal of physiology 1979;294():279-301.
1979: D A Eisner; William Lederer
Inotropic and arrhythmogenic effects of potassium-depleted solutions on mammalian cardiac muscle.
The Journal of physiology 1979;294():255-77.
1979: D A Eisner; William Lederer; D Noble
Caffeine and tetracaine abolish the slow inward calcium current in sheep cardiac Purkinje fibres [proceedings].
The Journal of physiology 1979;293():76P-77P.
1978: D DiFrancesco; D A Eisner; William Lederer
Low-potassium inotropy in cardiac muscle [proceedings].
The Journal of physiology 1978;284():138P-139P.
1978: Robert Kass; William Lederer; Richard W Tsien; R Weingart
Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres.
The Journal of physiology 1978;281():187-208.
1978: D A Eisner; William Lederer; C Ojeda
Arrhythmogenic effects of hypokalaemia on mammalian ventricular muscle [proceedings].
The Journal of physiology 1978;280():74P-75P.
1976: William Lederer; Richard W Tsien
Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres.
The Journal of physiology 1976;263(2):73-100.
1975: William Lederer; Richard W Tsien
Proceedings: Transient inward current underlying strophanthidin's enhancement of pace-maker activity in Purkinje fibres.
The Journal of physiology 1975;249(1):40P-41P.