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Niels Jessen

Research Profile

Anatomy

Muscle, Skeletal

Chemicals & Drugs

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Glucose Clamp Technique

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Mads Buhl; Jakob Gjedsted; Niels Jessen; Jens O L Jørgensen; Thomas K-Hafstrøm; Andreas B Møller; Roni R Nielsen; Steen Pedersen; Henriette Pilegaard; Else Tønnesen; Mikkel H Vendelbo; Esben Thyssen Vestergaard; Rasmus S Biensø; Ermina Bosnjak; Niels Møller
Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg.
Christian Høst; David M Hougaard; Michael D Jensen; Niels Jessen; Søren Nielsen; Steen B Pedersen; Britt Christensen; Jens S Christiansen; Lars C Gormsen; Claus H Gravholt
Independent Effects of Testosterone on Lipid Oxidation and VLDL-TG Production: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
Karen Louise Thomsen; Niels Kristian Aagaard; Henning Grønbaek; Jens Juul Holst; Niels Jessen; Andreas Buch Møller; Hendrik Vilstrup
Regulation of urea synthesis during the acute-phase response in rats.

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All Publications

2013: Mads Buhl; Jakob Gjedsted; Niels Jessen; Jens O L Jørgensen; Thomas K-Hafstrøm; Andreas B Møller; Roni R Nielsen; Steen Pedersen; Henriette Pilegaard; Else Tønnesen; Mikkel H Vendelbo; Esben Thyssen Vestergaard; Rasmus S Biensø; Ermina Bosnjak; Niels Møller
Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg.
The Journal of clinical endocrinology and metabolism 2013;98(5):2090-9.
2013: Christian Høst; David M Hougaard; Michael D Jensen; Niels Jessen; Søren Nielsen; Steen B Pedersen; Britt Christensen; Jens S Christiansen; Lars C Gormsen; Claus H Gravholt
Independent Effects of Testosterone on Lipid Oxidation and VLDL-TG Production: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
Diabetes 2013;62(5):1409-16.
2013: Karen Louise Thomsen; Niels Kristian Aagaard; Henning Grønbaek; Jens Juul Holst; Niels Jessen; Andreas Buch Møller; Hendrik Vilstrup
Regulation of urea synthesis during the acute-phase response in rats.
American journal of physiology. Gastrointestinal and liver physiology 2013;304(7):G680-6.
2013: Morten M Poulsen; Yulia Radko; Hans Stødkilde-Jørgensen; Poul F Vestergaard; Lars P Christensen; Berthil F Clasen; Niels Jessen; Niels Møller; Steen B Pedersen; Jens Otto L Jørgensen
High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition.
Diabetes 2013;62(4):1186-95.
2012: Karen Louise Thomsen; Allan Flyvbjerg; Jan Frystyk; Henning Grønbaek; Peter Holland-Fischer; Niels Jessen; Thomas Damgaard Sandahl; Hendrik Vilstrup
Changes in adipokines after transjugular intrahepatic porto-systemic shunt indicate an anabolic shift in metabolism.
Clinical nutrition (Edinburgh, Scotland) 2012;31(6):940-5.
2012: Mohammad Madani Ibrahim; Niels Jessen; Erik-Jan Lock; Sten Lund; Even Fjære; Livar Frøyland; Hubert Vidal; Jérôme Ruzzin
Metabolic impacts of high dietary exposure to persistent organic pollutants in mice.
Toxicology letters 2012;215(1):8-15.
2012: Morten Møller Poulsen; Bjørn Richelsen; Berthil F Clasen; Stephen Hamilton-Dutoit; Niels Jessen; Thomas N Kjær; Jens Ø Larsen; Søren K Paulsen; Steen B Pedersen
Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet.
Nutrition research (New York, N.Y.) 2012;32(9):701-8.
2012: Kristian Vissing; J Farup; T Kjølhede; S L McGee; M H Vendelbo; Niels Jessen
AMPK vs mTORC1 signaling: genuine exercise effects of differentiated exercise in humans. Response to letter to editor by Dr A. K. Yamada.
Scandinavian journal of medicine & science in sports 2012;22(4):580-1.
2012: Thomas S Nielsen; L Orskov; Steen Pedersen; Roni R Nielsen; Niels Jessen; Jens O Jørgensen; Ulla Kampmann; Sten Lund; Niels Møller
Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2012;97(7):E1348-52.
2012: Michael Madsen; Louise Møller; Steen B Pedersen; Hans Stødkilde-Jørgensen; Mikkel Holm Vendelbo; Britt Christensen; Allan Flyvbjerg; Jan Frystyk; Troels Krarup Hansen; Niels Jessen; Thomas Krusenstjerna-Hafstrøm; Jens Otto L Jørgensen
Fat content in liver and skeletal muscle changes in a reciprocal manner in patients with acromegaly during combination therapy with a somatostatin analog and a GH receptor antagonist: a randomized clinical trial.
The Journal of clinical endocrinology and metabolism 2012;97(4):1227-35.
2012: Britt Christensen; Niels Jessen; Thomas Krusenstjerna-Hafstrøm; Michael Madsen; Niels Møller; Steen B Pedersen; Mikkel H Vendelbo; Jens Otto L Jørgensen
Erythropoietin administration acutely stimulates resting energy expenditure in healthy young men.
Journal of applied physiology (Bethesda, Md. : 1985) 2012;112(7):1114-21.
2012: M H Vendelbo; L Møller; J O L Jørgensen; L J Goodyear; T Krusenstjerna-Hafstrøm; H Stødkilde-Jørgensen; N Møller; T S Nielsen; B F F Clasen; M Madsen; J F P Wojtaszewski; S B Pedersen; J T Treebak; Niels Jessen
Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2012;302(2):E190-200.
2012: Britt Christensen; Niels Jessen; John J Kopchick; Carsten Lundby; Niels Møller; Thomas S Nielsen; Steen B Pedersen; Henriette Pilegaard; Poul F Vestergaard; Jens Otto L Jørgensen
Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects.
PloS one 2012;7(2):e31857.
2012: Lasse Solskov; Nils E Magnusson; Torsten T Nielsen; Ole Schmitz; Hans Erik Bøtker; Niels Jessen; Steen B Kristiansen; Sten Lund
Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).
Molecular and cellular biochemistry 2012;360(1-2):353-62.
2011: Thomas S Nielsen; Steen Pedersen; Mikkel H Vendelbo; Niels Jessen; Jens O Jørgensen; Sten Lund; Niels Møller
Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue.
The Journal of clinical endocrinology and metabolism 2011;96(8):E1293-7.
2011: T Krusenstjerna-Hafstrøm; Niels Møller; Steen Pedersen; Jens Sandahl Christiansen; B F Clasen; Niels Jessen; J O L Jørgensen
Growth hormone (GH)-induced insulin resistance is rapidly reversible: an experimental study in GH-deficient adults.
The Journal of clinical endocrinology and metabolism 2011;96(8):2548-57.
2011: Niels Jessen; Aina S Lihn; Jonas Nygren; Anders Thorell; Ding An; Michael F Hirshman; Laurie J Goodyear
Exercise increases TBC1D1 phosphorylation in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2011;301(1):E164-71.
2011: Karen L Thomsen; Niels Kristian Aagaard; Henning Grønbaek; Jens J Holst; Niels Jessen; Jan Frystyk; Hendrik Vilstrup
IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats.
Scandinavian journal of clinical and laboratory investigation 2011;71(2):150-6.
2011: Lars C Gormsen; C Nielsen; Niels Jessen; J O L Jørgensen; Niels Møller
Time-course effects of physiological free fatty acid surges on insulin sensitivity in humans.
Acta physiologica (Oxford, England) 2011;201(3):349-56.
2011: Esben Thyssen Vestergaard; Mads Buhl; Jakob Gjedsted; Michael Madsen; Niels Jessen; Soren Nielsen; Bruce D Gaylinn; Jianhua Liu; Michael O Thorner; Niels Moller; Jens Otto Lunde Jorgensen
Acute peripheral metabolic effects of intraarterial ghrelin infusion in healthy young men.
The Journal of clinical endocrinology and metabolism 2011;96(2):468-77.
2011: Ulla Kampmann; Sten Lund; Niels Møller; Thomas Svava Nielsen; L Orskov; Steen Bønløkke Pedersen; Britt Christensen; Niels Jessen
GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance.
PloS one 2011;6(11):e27854.
2011: Mohammad Madani Ibrahim; Niels Jessen; Brigitte Le Magueresse Battistoni; Erik-Jan Lock; Sten Lund; Lise Madsen; Emmanuelle Meugnier; Danielle Naville; Heidi Amlund; Even Fjære; Livar Frøyland; Hubert Vidal; Jérôme Ruzzin
Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice.
PloS one 2011;6(9):e25170.
2011: Thomas Krusenstjerna-Hafstrøm; Michael Madsen; Mikkel H Vendelbo; Steen B Pedersen; Jens S Christiansen; Niels Møller; Niels Jessen; Jens O L Jørgensen
Insulin and GH signaling in human skeletal muscle in vivo following exogenous GH exposure: impact of an oral glucose load.
PloS one 2011;6(5):e19392.
2011: Britt Christensen; Lucila Sackmann-Sala; Diana Cruz-Topete; Jens Otto L Jørgensen; Niels Jessen; Carsten Lundby; John J Kopchick
Novel serum biomarkers for erythropoietin use in humans: a proteomic approach.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;110(1):149-56.
2011: Karen L Thomsen; Niels K Aagaard; Susanne S Nielsen; Henning Grønbaek; Niels Jessen; Jan Frystyk; Hendrik Vilstrup
Unchanged capacity of urea synthesis during acute phase response in rats.
European journal of clinical investigation 2011;41(1):16-22.
2010: Kanokwan Vichaiwong; Suneet Purohit; Ding An; Taro Toyoda; Niels Jessen; Michael F Hirshman; Laurie J Goodyear
Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.
The Biochemical journal 2010;431(2):311-20.
2010: Mikkel H Vendelbo; Jens O Jørgensen; Steen Pedersen; Lars C Gormsen; Sten Lund; Ole Schmitz; Niels Jessen; Niels Møller
Exercise and fasting activate growth hormone-dependent myocellular signal transducer and activator of transcription-5b phosphorylation and insulin-like growth factor-I messenger ribonucleic acid expression in humans.
The Journal of clinical endocrinology and metabolism 2010;95(9):E64-8.
2010: Niels Jessen; Ho-Jin Koh; Clifford D Folmes; Cory Wagg; Nobuharu Fujii; Bo Løfgren; Cordula M Wolf; Charles I Berul; Michael F Hirshman; Gary D Lopaschuk; Laurie J Goodyear
Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.
Biochimica et biophysica acta 2010;1802(7-8):593-600.
2010: Niels Jessen; Laurie J Goodyear
Diabetes: Exercise and type 2 diabetes mellitus--good for body and mind?
Nature reviews. Endocrinology 2010;6(6):303-4.
2010: Carol A Witczak; Niels Jessen; Daniel M Warro; Taro Toyoda; Nobuharu Fujii; Mark E Anderson; Michael F Hirshman; Laurie J Goodyear
CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2010;298(6):E1150-60.
2010: Esben S Buhl; Thomas Korgaard Jensen; Niels Jessen; Betina Elfving; Christian S Buhl; Steen B Kristiansen; Rasmus Pold; Lasse Solskov; Ole Schmitz; Gregers Wegener; Sten Lund; Kitt Falk Petersen
Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats.
American journal of physiology. Endocrinology and metabolism 2010;298(5):E920-9.
2010: M F Bennetzen; T S Nielsen; Søren Kildeberg Paulsen; Jørgen Bendix; Sanne Fisker; Niels Jessen; S Lund; Bjørn Richelsen; Steen Pedersen
Reduced cannabinoid receptor 1 protein in subcutaneous adipose tissue of obese.
European journal of clinical investigation 2010;40(2):121-6.
2009: Louise Moller; Helene Norrelund; Niels Jessen; Allan Flyvbjerg; Steen Pedersen; Bruce D Gaylinn; Jianhua Liu; Michael O Thorner; Niels Moller; Jens Otto Lunde Jorgensen
Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.
The Journal of clinical endocrinology and metabolism 2009;94(11):4524-32.
2009: Katja S C Gollisch; Josef Brandauer; Niels Jessen; Taro Toyoda; Ali Nayer; Michael F Hirshman; Laurie J Goodyear
Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E495-504.
2009: Steen B Kristiansen; Lasse Solskov; Niels Jessen; Bo Løfgren; Ole Schmitz; Jens Erik Nielsen-Kudsk; Torsten T Nielsen; Hans Erik Bøtker; Sten Lund
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases myocardial glucose uptake during reperfusion and induces late pre-conditioning: potential role of AMP-activated protein kinase.
Basic & clinical pharmacology & toxicology 2009;105(1):10-6.
2009: Niels Møller; Lars C Gormsen; Ole Schmitz; Sten Lund; Jens Otto L Jørgensen; Niels Jessen
Free fatty acids inhibit growth hormone/signal transducer and activator of transcription-5 signaling in human muscle: a potential feedback mechanism.
The Journal of clinical endocrinology and metabolism 2009;94(6):2204-7.
2009: Kamille Smidt; Niels Jessen; Andreas Brønden Petersen; Agnete Larsen; Nils Magnusson; Johanne Bruun Jeppesen; Meredin Stoltenberg; Janetta G Culvenor; Andrew Tsatsanis; Birgitte Brock; Ole Schmitz; Lise Wogensen; Ashley I Bush; Jørgen Rungby
SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.
PloS one 2009;4(5):e5684.
2008: Esben Thyssen Vestergaard; Lars Christian Gormsen; Niels Jessen; Sten Lund; Troels Krarup Hansen; Niels Moller; Jens Otto Lunde Jorgensen
Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling.
Diabetes 2008;57(12):3205-10.
2008: Nobuharu Fujii; Richard C Ho; Yasuko Manabe; Niels Jessen; Taro Toyoda; William L Holland; Scott A Summers; Michael F Hirshman; Laurie J Goodyear
Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.
Diabetes 2008;57(11):2958-66.
2008: Andrew W Norris; Michael F Hirshman; Jianrong Yao; Niels Jessen; Nicolas Musi; Lihong Chen; William I Sivitz; Laurie J Goodyear; C Ronald Kahn
Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.
Endocrinology 2008;149(11):5374-83.
2008: Lasse Solskov; Bo Løfgren; Steen B Kristiansen; Niels Jessen; Rasmus Pold; Torsten T Nielsen; Hans Erik Bøtker; Ole Schmitz; Sten Lund
Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration.
Basic & clinical pharmacology & toxicology 2008;103(1):82-7.
2008: Charlotte Nielsen; Lars C Gormsen; Niels Jessen; Steen Pedersen; Niels Møller; Sten Lund; Jens Otto Lunde Jørgensen
Growth hormone signaling in vivo in human muscle and adipose tissue: impact of insulin, substrate background, and growth hormone receptor blockade.
The Journal of clinical endocrinology and metabolism 2008;93(7):2842-50.
2008: Niels Jessen; E Selmer Buhl; R Pold; O Schmitz; S Lund
A novel insulin sensitizer (S15511) enhances insulin-stimulated glucose uptake in rat skeletal muscles.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(4):269-75.
2007: Torben Østergård; Niels Jessen; Ole Schmitz; Lawrence J. Manderino
The effect of exercise, training, and inactivity on insulin sensitivity in diabetics and their relatives: what is new?
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2007;32(3):541-8.
2007: Lars C Gormsen; Niels Jessen; Jakob Gjedsted; Signe Gjedde; Helene Nørrelund; Sten Lund; Jens Sandahl Christiansen; Søren Nielsen; Ole Schmitz; Niels Møller
Dose-response effects of free fatty acids on glucose and lipid metabolism during somatostatin blockade of growth hormone and insulin in humans.
The Journal of clinical endocrinology and metabolism 2007;92(5):1834-42.
2006: Niels Jessen; Esben S Buhl; Ole Schmitz; Sten Lund
Impaired insulin action despite upregulation of proximal insulin signaling: novel insights into skeletal muscle insulin resistance in liver cirrhosis.
Journal of hepatology 2006;45(6):797-804.
2006: Carol A Witczak; Michael F Hirshman; Niels Jessen; Nobuharu Fujii; Matthew M Seifert; J Brandauer; G S Hotamisligil; Laurie J Goodyear
JNK1 deficiency does not enhance muscle glucose metabolism in lean mice.
Biochemical and biophysical research communications 2006;350(4):1063-8.
2006: Ho-Jin Koh; David E Arnolds; Nobuharu Fujii; Thien Tran; Marc J Rogers; Niels Jessen; Yangfeng Li; Chong Wee Liew; Richard C Ho; Michael F Hirshman; Rohit N Kulkarni; C Ronald Kahn; Laurie J Goodyear
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.
Molecular and cellular biology 2006;26(22):8217-27.
2006: Nobuharu Fujii; Niels Jessen; Laurie J Goodyear
AMP-activated protein kinase and the regulation of glucose transport.
American journal of physiology. Endocrinology and metabolism 2006;291(5):E867-77.
2006: Jens Otto Lunde Jørgensen; Niels Jessen; Steen Pedersen; Esben Thyssen Vestergaard; Lars C Gormsen; Sten A Lund; Nils Billestrup
GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus.
American journal of physiology. Endocrinology and metabolism 2006;291(5):E899-905.
2006: Henning F Kramer; Carol A Witczak; Nobuharu Fujii; Niels Jessen; Eric B Taylor; David E Arnolds; Kei Sakamoto; Michael F Hirshman; Laurie J Goodyear
Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle.
Diabetes 2006;55(7):2067-76.
2005: Niels Jessen; Laurie J Goodyear
Contraction signaling to glucose transport in skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;99(1):330-7.
2005: Rasmus Pold; Lasse S Jensen; Niels Jessen; Esben S Buhl; Ole Schmitz; Allan Flyvbjerg; Nobuharu Fujii; Laurie J Goodyear; Carsten F Gotfredsen; Christian L Brand; Sten Lund
Long-term AICAR administration and exercise prevents diabetes in ZDF rats.
Diabetes 2005;54(4):928-34.
2005: Jens Otto Lunde Jørgensen; Esben Thyssen Vestergaard; Lars C Gormsen; Niels Jessen; Helene Nørrelund; Jens Sandahl Christiansen; Niels Møller
Metabolic consequences of GH deficiency.
Journal of endocrinological investigation 2005;28(5 Suppl):47-51.
2005: Niels Jessen; Christian Born Djurhuus; Jens Otto Lunde Jørgensen; Lasse S Jensen; Niels Møller; Sten Lund; Ole Schmitz
Evidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion.
American journal of physiology. Endocrinology and metabolism 2005;288(1):E194-9.
2004: Aina S Lihn; Niels Jessen; Steen Pedersen; Sten Lund; Bjørn Richelsen
AICAR stimulates adiponectin and inhibits cytokines in adipose tissue.
Biochemical and biophysical research communications 2004;316(3):853-8.
2004: Jens Otto Lunde Jørgensen; Morten Krag; Niels Jessen; Helene Nørrelund; Esben Thyssen Vestergaard; Niels Møller; Jens Sandahl Christiansen
Growth hormone and glucose homeostasis.
Hormone research 2004;62 Suppl 3():51-5.
2003: Jian-Wen Chen; Thomas Ledet; Hans Orskov; Niels Jessen; Sten Lund; Jonathan Whittaker; Pierre De Meyts; Maj Britt Larsen; Jens Sandahl Christiansen; Jan Frystyk
A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum.
American journal of physiology. Endocrinology and metabolism 2003;284(6):E1149-55.
2003: Niels Jessen; Rasmus Pold; Esben S Buhl; Lasse S Jensen; Ole Schmitz; Sten Lund
Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(4):1373-9.
2002: Esben S Buhl; Niels Jessen; Rasmus Pold; Thomas Ledet; Allan Flyvbjerg; Steen Pedersen; Oluf Pedersen; Ole Schmitz; Sten Lund
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome.
Diabetes 2002;51(7):2199-206.
2001: Esben S Buhl; Niels Jessen; Ole Schmitz; Steen Pedersen; Oluf Pedersen; G D Holman; Sten Lund
Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner.
Diabetes 2001;50(1):12-7.