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Krzysztof Jozwiak

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Chemicals & Drugs

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Ruin Moaddel; Avraham Rosenberg; Lawrence Toll; Thao Tran; Galia Abdrakhmanova; Lucita Jimenez; Krzysztof Jozwiak; Joanna Kozak; Yingxian Xiao; Carlos A Zarate; irving william wainer
Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors.
Hugo R Arias; Dominik Feuerbach; David J Lapinsky; Katarzyna M Targowska-Duda; Shaili Aggarwal; Krzysztof Jozwiak
Structural and functional interaction of (±)-2-(N-tert-butylamino)-3'-iodo-4'-azidopropiophenone, a photoreactive bupropion derivative, with nicotinic acetylcholine receptors.
Lawrence Toll; James E Bupp; Lucita Jimenez; Krzysztof Jozwiak; Joseph A Kozocas; Karolina Pajak; Anita Plazinska; Mary J Tanga; irving william wainer
Thermodynamics and docking of agonists to the β(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand.

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All Publications

2013: Ruin Moaddel; Avraham Rosenberg; Lawrence Toll; Thao Tran; Galia Abdrakhmanova; Lucita Jimenez; Krzysztof Jozwiak; Joanna Kozak; Yingxian Xiao; Carlos A Zarate; irving william wainer
Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors.
European journal of pharmacology 2013;698(1-3):228-34.
2012: Hugo R Arias; Dominik Feuerbach; David J Lapinsky; Katarzyna M Targowska-Duda; Shaili Aggarwal; Krzysztof Jozwiak
Structural and functional interaction of (±)-2-(N-tert-butylamino)-3'-iodo-4'-azidopropiophenone, a photoreactive bupropion derivative, with nicotinic acetylcholine receptors.
Neurochemistry international 2012;61(8):1433-41.
2012: Lawrence Toll; James E Bupp; Lucita Jimenez; Krzysztof Jozwiak; Joseph A Kozocas; Karolina Pajak; Anita Plazinska; Mary J Tanga; irving william wainer
Thermodynamics and docking of agonists to the β(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand.
Molecular pharmacology 2012;81(6):846-54.
2012: M Kolinski; A Plazinska; Krzysztof Jozwiak
Recent progress in understanding of structure, ligand interactions and the mechanism of activation of the β₂-adrenergic receptor.
Current medicinal chemistry 2012;19(8):1155-63.
2011: Hugo R Arias; Dominik Feuerbach; Katarzyna M Targowska-Duda; Krzysztof Jozwiak
Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states.
The international journal of biochemistry & cell biology 2011;43(9):1330-9.
2011: Dorota Latek; Anita Plazinska; Rafal Bombolewski; Aleksander Debinski; Umesh Ghoshdastider; Krzysztof Jozwiak; Michal Kolinski; Slawomir Filipek
Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.
Journal of molecular modeling 2011;17(9):2353-66.
2011: Krzysztof Jozwiak; Anita Plazinska; Lawrence Toll; Anthony Woo; Rui-Ping Xiao; Lucita Jimenez; irving william wainer
Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: ligand-directed chiral recognition.
Chirality 2011;23 Suppl 1():E1-6.
2010: Krzysztof Jozwiak; Lawrence Toll; Lucita Jimenez; Anthony Yiu-Ho Woo; Rui-Ping Xiao; irving william wainer
The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor.
Biochemical pharmacology 2010;79(11):1610-5.
2010: Krzysztof Jozwiak; Anthony Woo; Mary J Tanga; Lawrence Toll; Lucita Jimenez; Joseph A Kozocas; Anita Plazinska; Rui-Ping Xiao; irving william wainer
Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.
Bioorganic & medicinal chemistry 2010;18(2):728-36.
2008: Mitesh Sanghvi; Ayman K Hamouda; Krzysztof Jozwiak; Michael P Blanton; James R Trudell; Hugo R Arias
Identifying the binding site(s) for antidepressants on the Torpedo nicotinic acetylcholine receptor: [3H]2-azidoimipramine photolabeling and molecular dynamics studies.
Biochimica et biophysica acta 2008;1778(12):2690-9.
2008: Krzysztof Jozwiak; Ruin Moaddel; Sarangan Ravichandran; Anita Plazinska; Joanna Kozak; Sharvil Patel; Rika Yamaguchi; irving william wainer
Exploring enantiospecific ligand-protein interactions using cellular membrane affinity chromatography: chiral recognition as a dynamic process.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;875(1):200-7.
2008: P Bhatia; M Kolinski; Ruin Moaddel; Krzysztof Jozwiak; irving william wainer
Determination and modelling of stereoselective interactions of ligands with drug transporters: a key dimension in the understanding of drug disposition.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(7-8):656-75.
2008: Krzysztof Jozwiak; Krystiana A Krzysko; Lukasz Bojarski; Magdalena Gacia; Slawomir Filipek
Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs.
ChemMedChem 2008;3(4):627-34.
2008: Michał P Marszałł; Ruin Moaddel; Krzysztof Jozwiak; Michel Bernier; irving william wainer
Initial synthesis and characterization of an immobilized heat shock protein 90 column for online determination of binding affinities.
Analytical biochemistry 2008;373(2):313-21.
2007: Krzysztof Jozwiak; Sarangan Ravichandran; Jack R Collins; Ruin Moaddel; irving william wainer
Interaction of noncompetitive inhibitors with the alpha3beta2 nicotinic acetylcholine receptor investigated by affinity chromatography and molecular docking.
Journal of medicinal chemistry 2007;50(24):6279-83.
2007: Ruin Moaddel; Krzysztof Jozwiak; irving william wainer
Allosteric modifiers of neuronal nicotinic acetylcholine receptors: new methods, new opportunities.
Medicinal research reviews 2007;27(5):723-53.
2007: Krzysztof Jozwiak; Chakir Khalid; Mary J Tanga; Ilona Berzetei-Gurske; Lucita Jimenez; Joseph A Kozocas; Anthony Woo; Weizhong Zhu; Rui-Ping Xiao; Darrell R. Abernethy; irving william wainer
Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.
Journal of medicinal chemistry 2007;50(12):2903-15.
2006: Krzysztof Jozwiak; Ruin Moaddel; Rika Yamaguchi; Alexandre Maciuk; irving william wainer
Non-competitive inhibitory activities of morphinan and morphine derivatives at the alpha 3 beta 4 Neuronal nicotinic acetylcholine receptor determined using nonlinear chromatography and chemometric techniques.
Pharmaceutical research 2006;23(9):2175-82.
2006: Krzysztof Jozwiak; Cezary Zekanowski; Slawomir Filipek
Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction.
Journal of neurochemistry 2006;98(5):1560-72.
2005: Ruin Moaddel; Sharvil Patel; Krzysztof Jozwiak; Rika Yamaguchi; P C Ho; irving william wainer
Enantioselective binding to the human organic cation transporter-1 (hOCT1) determined using an immobilized hOCT1 liquid chromatographic stationary phase.
Chirality 2005;17(8):501-6.
2005: Ruin Moaddel; Krzysztof Jozwiak; Rika Yamaguchi; irving william wainer
Direct chromatographic determination of dissociation rate constants of ligand-receptor complexes: assessment of the interaction of noncompetitive inhibitors with an immobilized nicotinic acetylcholine receptor-based liquid chromatography stationary phase.
Analytical chemistry 2005;77(16):5421-6.
2005: Krzysztof Jozwiak; Ruin Moaddel; Rika Yamaguchi; Sarangan Ravichandran; Jack R Collins; irving william wainer
Qualitative assessment of IC50 values of inhibitors of the neuronal nicotinic acetylcholine receptor using a single chromatographic experiment and multivariate cluster analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;819(1):169-74.
2005: Ruin Moaddel; Krzysztof Jozwiak; Kevin Whittington; irving william wainer
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors.
Analytical chemistry 2005;77(3):895-901.
2004: Tarun K Sarkar; Sankar Basak; irving william wainer; Ruin Moaddel; Rika Yamaguchi; Krzysztof Jozwiak; Hui-Ting Chen; Chun-Cheng Lin
Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine.
Journal of medicinal chemistry 2004;47(27):6691-701.
2004: Ruin Moaddel; Krzysztof Jozwiak; Rika Yamaguchi; Christopher Cobello; Kevin Whittington; Tarun K Sarkar; Sankar Basak; irving william wainer
On-line screening of conformationally constrained nicotines and anabasines for agonist activity at the alpha3beta4- and alpha4beta2-nicotinic acetylcholine receptors using immobilized receptor-based liquid chromatographic stationary phases.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;813(1-2):235-40.
2004: Krzysztof Jozwiak; Sarangan Ravichandran; Jack R Collins; irving william wainer
Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking.
Journal of medicinal chemistry 2004;47(16):4008-21.
2003: Krzysztof Jozwiak; Susan C Hernandez; Kenneth J Kellar; irving william wainer
Enantioselective interactions of dextromethorphan and levomethorphan with the alpha 3 beta 4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;797(1-2):373-9.
2002: Krzysztof Jozwiak; Jun Haginaka; Ruin Moaddel; irving william wainer
Displacement and nonlinear chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor liquid chromatographic stationary phase.
Analytical chemistry 2002;74(18):4618-24.