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Richard Eastman

Research Profile

Chemicals & Drugs

Physiology

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Drug Design

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Molecular Sequence Data

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Malaria

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Publications

TOP 3
Richard Eastman; Fidock David
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.
Neekesh V Dharia; Amar Bir Singh Sidhu; Maria Cassera; Scott J Westenberger; Selina Elisabeth Ruth Bopp; Richard Eastman; David Plouffe; Serge Batalov; Daniel J Park; Sarah K Volkman; Dyann F Wirth; Yingyao Zhou; Fidock David; Elizabeth A Winzeler
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.
Fidock David; Richard Eastman; Stephen A Ward; Steven R Meshnick
Recent highlights in antimalarial drug resistance and chemotherapy research.

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All Publications

2009: Richard Eastman; Fidock David
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.
Nature reviews. Microbiology 2009;7(12):864-74.
2009: Neekesh V Dharia; Amar Bir Singh Sidhu; Maria Cassera; Scott J Westenberger; Selina Elisabeth Ruth Bopp; Richard Eastman; David Plouffe; Serge Batalov; Daniel J Park; Sarah K Volkman; Dyann F Wirth; Yingyao Zhou; Fidock David; Elizabeth A Winzeler
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.
Genome biology 2009;10(2):R21.
2008: Fidock David; Richard Eastman; Stephen A Ward; Steven R Meshnick
Recent highlights in antimalarial drug resistance and chemotherapy research.
Trends in parasitology 2008;24(12):537-44.
2007: John R Gillespie; Kohei Yokoyama; Karen Lu; Richard Eastman; James G Bollinger; Wesley C Van Voorhis; Michael H Gelb; Frederick S Buckner
C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins.
Molecular and biochemical parasitology 2007;153(2):115-24.
2007: Richard Eastman; John White; Oliver Hucke; Kohei Yokoyama; Christophe Verlinde; Michael A Hast; Lorena S Beese; Michael H Gelb; Pradipsinh K Rathod; Wesley C Van Voorhis
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
Molecular and biochemical parasitology 2007;152(1):66-71.
2006: Richard Eastman; Frederick S Buckner; Kohei Yokoyama; Michael H Gelb; Wesley C Van Voorhis
Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation.
Journal of lipid research 2006;47(2):233-40.
2005: Richard Eastman; Lynn K Barrett; Kent Dupuis; Frederick S Buckner; Wesley C Van Voorhis
Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation.
Transfusion 2005;45(9):1459-63.
2005: Frederick S Buckner; Richard Eastman; Kohei Yokoyama; Michael H Gelb; Wesley C Van Voorhis
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
Current opinion in investigational drugs (London, England : 2000) 2005;6(8):791-7.
2005: Richard Eastman; John White; Oliver Hucke; Kevin Bauer; Kohei Yokoyama; Laxman Nallan; Debopam Chakrabarti; Christophe Verlinde; Michael H Gelb; Pradipsinh K Rathod; Wesley C Van Voorhis
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
The Journal of biological chemistry 2005;280(14):13554-9.
2004: Jia L Song; Jo Beth Harry; Richard Eastman; Brian G Oliver; Theodore C White
The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.
Antimicrobial agents and chemotherapy 2004;48(4):1136-44.
2004: Junko Ohkanda; Frederick S Buckner; Jeffrey W Lockman; Kohei Yokoyama; Dora Carrico; Richard Eastman; Kate de Luca-Fradley; Wendy Davies; Simon L Croft; Wesley C Van Voorhis; Michael H Gelb; Said M Sebti; Andrew D Hamilton
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
2003: Frederick S Buckner; Bridget M Joubert; Sean M Boyle; Richard Eastman; Christophe Verlinde; Seiichi P T Matsuda
Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase.
Molecular and biochemical parasitology 2003;132(2):75-81.
2003: Jerald C Hinshaw; Dae-Yeon Suh; Philippe Garnier; Frederick S Buckner; Richard Eastman; Seiichi P T Matsuda; Bridget M Joubert; Isabelle Coppens; Keith A Joiner; Salim Merali; Theodore E Nash; Glenn D Prestwich
Oxidosqualene cyclase inhibitors as antimicrobial agents.
Journal of medicinal chemistry 2003;46(20):4240-3.
2003: Michael H Gelb; Wesley C Van Voorhis; Frederick S Buckner; Kohei Yokoyama; Richard Eastman; Elisabeth P Carpenter; Chrysoula Panethymitaki; Katherine A Brown; Deborah Smith
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.
Molecular and biochemical parasitology 2003;126(2):155-63.
2003: Wesley C Van Voorhis; Lynn K Barrett; Richard Eastman; Ryan D Alfonso; Kent Dupuis
Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (amotosalen HCl) and long-wavelength UV.
Antimicrobial agents and chemotherapy 2003;47(2):475-9.
2002: Frederick S Buckner; Richard Eastman; José L Nepomuceno-Silva; Emily C Speelmon; Peter J Myler; Wesley C Van Voorhis; Kohei Yokoyama
Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major.
Molecular and biochemical parasitology 2002;122(2):181-8.