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Nigel Bunnett

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Farzad Alemi; Nigel W Bunnett; Fiore Cattaruzza; Ferda Cevikbas; Graeme S Cottrell; Pierangelo Geppetti; Raquel Guerrero-Alba; Edwin Kwon; TinaMarie Lieu; Victoria Lyo; Serena Materazzi; Romina Nassini; Daniel P Poole; Kristina Schoonjans; Martin Steinhoff; Eduardo Valdez-Morales; Stephen J Vanner; Carlos U Corvera
The TGR5 receptor mediates bile acid-induced itch and analgesia.
Senthilkumar Rajagopal; Ruizhe Zhou; Sayak Bhattacharya; Nigel W Bunnett; Carlos U Corvera; John R Grider; Divya P Kumar; Sunila Mahavadi; Karnam S Murthy
Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.
Daniel P Poole; Nicholas A Veldhuis; Fe C Abogadie; Silvia Amadesi; William Darby; Michael J Lew; Wolfgang Liedtke; TinaMarie Lieu; Peter McIntyre; Nigel W Bunnett
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

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2013: Farzad Alemi; Nigel W Bunnett; Fiore Cattaruzza; Ferda Cevikbas; Graeme S Cottrell; Pierangelo Geppetti; Raquel Guerrero-Alba; Edwin Kwon; TinaMarie Lieu; Victoria Lyo; Serena Materazzi; Romina Nassini; Daniel P Poole; Kristina Schoonjans; Martin Steinhoff; Eduardo Valdez-Morales; Stephen J Vanner; Carlos U Corvera
The TGR5 receptor mediates bile acid-induced itch and analgesia.
The Journal of clinical investigation 2013;123(4):1513-30.
2013: Senthilkumar Rajagopal; Ruizhe Zhou; Sayak Bhattacharya; Nigel W Bunnett; Carlos U Corvera; John R Grider; Divya P Kumar; Sunila Mahavadi; Karnam S Murthy
Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.
American journal of physiology. Gastrointestinal and liver physiology 2013;304(5):G527-35.
2013: Daniel P Poole; Nicholas A Veldhuis; Fe C Abogadie; Silvia Amadesi; William Darby; Michael J Lew; Wolfgang Liedtke; TinaMarie Lieu; Peter McIntyre; Nigel W Bunnett
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.
The Journal of biological chemistry 2013;288(8):5790-802.
2013: fiore cattaruzza; Daniel P Poole; Nigel W Bunnett
Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease.
Biochemical Society transactions 2013;41(1):137-43.
2013: Farzad Alemi; Nigel W Bunnett; fiore cattaruzza; Jonathan Chiu; John R Grider; Daniel P Poole; Kristina Schoonjans; Carlos U Corvera
The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.
Gastroenterology 2013;144(1):145-54.
2012: Victoria Lyo; James Ostroff; Margot Paulick; Austin W Walker; Matthew Bogyo; Nigel W Bunnett; James Buxbaum; fiore cattaruzza; Jordan Cloyd; Daniel Cox; Eileen F Grady; Tyson N Kim; Kimberly S Kirkwood
Active cathepsins B, L, and S in murine and human pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(8):G894-903.
2012: Silke Haerteis; Ian Henderson; Vera Baraznenok; Marko Bertog; Nigel W Bunnett; Annabel Krappitz; Matteus Krappitz; Erik Lindström; Jane E Murphy; Christoph Korbmacher
Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S.
Pflügers Archiv : European journal of physiology 2012;464(4):353-65.
2012: Nicholas A Veldhuis; Daniel P Poole; Fe C Abogadie; Nigel W Bunnett; Helge Eilers; Jason J Ivanusic; Ernest A Jennings; Michael J Lew; Peter McIntyre
N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.
The Journal of biological chemistry 2012;287(26):21765-72.
2012: Ivy Ka Man Law; Jane E Murphy; Kyriaki Bakirtzi; Nigel W Bunnett; Charalabos Pothoulakis
Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1.
The Journal of biological chemistry 2012;287(18):15066-75.
2012: Burcu Hasdemir; Min Liao; Shilpi Mahajan; Nigel W Bunnett; Aditi Bhargava
Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations.
Molecular endocrinology (Baltimore, Md.) 2012;26(4):681-95.
2011: Juan-Carlos Pelayo; Daniel P Poole; Martin Steinhoff; Graeme S Cottrell; Nigel W Bunnett
Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones.
The Journal of physiology 2011;589(Pt 21):5213-30.
2011: fiore cattaruzza; James Hawkins; Charles Ibeakanma; Ella Jones; Kimberley Kirkwood; Victoria Lyo; David Pham; Eduardo Valdez-Morales; Stephen Vanner; Matthew Bogyo; Nigel W Bunnett
Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice.
Gastroenterology 2011;141(5):1864-74.e1-3.
2011: Jane E Murphy; Benjamin Padilla; Dirk Roosterman; Eva Brand; Nigel W Bunnett; Wendy J Cedron; Graeme S Cottrell; Micha Feld; Martin Steinhoff
Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor.
American journal of physiology. Cell physiology 2011;301(4):C780-91.
2011: Daniel P Poole; Gregory Scherrer; Christopher J Evans; Brigitte L Kieffer; Juan-Carlos Pelayo; Nigel W Bunnett
Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice.
Gastroenterology 2011;141(3):982-991.e1-8.
2011: Daniel P Poole; Romke Bron; fiore cattaruzza; Jonathon V Chiu; John B Furness; Gregory Gai; Eileen F Grady; Yien-Ming Kuo; Juan Carlos Pelayo; Nigel W Bunnett
Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine.
Gastroenterology 2011;141(2):565-75, 575.e1-4.
2011: Eugene P Ceppa; Victoria Lyo; Eileen F Grady; Wolfgang Knecht; Sarah Grahn; Anders Peterson; Nigel W Bunnett; Kimberly S Kirkwood; Fiore Cattaruzza
Serine proteases mediate inflammatory pain in acute pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology 2011;300(6):G1033-42.
2010: Nigel W Bunnett; Graeme S Cottrell
Trafficking and signaling of G protein-coupled receptors in the nervous system: implications for disease and therapy.
CNS & neurological disorders drug targets 2010;9(5):539-56.
2010: Eugene Ceppa; fiore cattaruzza; Victoria Lyo; Silvia Amadesi; Juan-Carlos Pelayo; Daniel P Poole; Natalya Vaksman; Wolfgang Liedtke; David M Cohen; Eileen F Grady; Nigel W Bunnett; Kimberly S Kirkwood
Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(3):G556-71.
2010: D P Poole; C Godfrey; fiore cattaruzza; Graeme S Cottrell; J G Kirkland; J C Pelayo; Nigel W Bunnett; Carlos U Corvera
Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2010;22(7):814-25, e227-8.
2010: Helge Eilers; fiore cattaruzza; Romina Nassini; Serena Materazzi; Eunice Andre; Catherine Chu; Graeme S Cottrell; Mark Schumacher; Pierangelo Geppetti; Nigel W Bunnett
Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction.
Anesthesiology 2010;112(6):1452-63.
2010: fiore cattaruzza; Ian Spreadbury; Marcela Miranda-Morales; Eileen F Grady; Stephen Vanner; Nigel W Bunnett
Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice.
American journal of physiology. Gastrointestinal and liver physiology 2010;298(1):G81-91.
2009: Jane E Murphy; Benjamin Padilla; Burcu Hasdemir; Graeme S Cottrell; Nigel W Bunnett
Endosomes: a legitimate platform for the signaling train.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17615-22.
2009: Burcu Hasdemir; Jane E Murphy; Graeme S Cottrell; Nigel W Bunnett
Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.
The Journal of biological chemistry 2009;284(41):28453-66.
2009: Silvia Amadesi; Andrew D Grant; Graeme S Cottrell; Natalya Vaksman; Daniel P Poole; Enrique Rozengurt; Nigel W Bunnett
Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.
The Journal of comparative neurology 2009;516(2):141-56.
2009: Graeme S Cottrell; Benjamin E Padilla; Silvia Amadesi; Daniel P Poole; Jane E Murphy; Markus Hardt; Dirk Roosterman; Martin Steinhoff; Nigel W Bunnett
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
The Journal of biological chemistry 2009;284(33):22411-25.
2008: Serena Materazzi; Romina Nassini; Eunice Andrè; Barbara Campi; Silvia Amadesi; Marcello Trevisani; Nigel W Bunnett; Riccardo Patacchini; Pierangelo Geppetti
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):12045-50.
2008: Eunice Andrè; Barbara Campi; Serena Materazzi; Marcello Trevisani; Silvia Amadesi; Daniela Massi; Christophe Creminon; Natalya Vaksman; Romina Nassini; Maurizio Civelli; Pier Giovanni Baraldi; Daniel P Poole; Nigel W Bunnett; Pierangelo Geppetti; Riccardo Patacchini
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.
The Journal of clinical investigation 2008;118(7):2574-82.
2008: Walter E B Sipe; Stuart M Brierley; Christopher M Martin; Benjamin D Phillis; Francisco Bautista Cruz; Eileen F Grady; Wolfgang Liedtke; David M Cohen; Stephen Vanner; L Ashley Blackshaw; Nigel W Bunnett
Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(5):G1288-98.
2008: Daniel P Poole; S Amadesi; E Rozengurt; Michelle Thacker; Nigel W Bunnett; John B Furness
Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(5):G1245-56.
2008: Dirk Roosterman; Cordula Kempkes; Graeme S Cottrell; Benjamin E Padilla; Nigel W Bunnett; Christoph W Turck; Martin Steinhoff
Endothelin-converting enzyme-1 degrades internalized somatostatin-14.
Endocrinology 2008;149(5):2200-7.
2008: Jochen K Lennerz; Victor Rühle; Eugene P Ceppa; Winfried Neuhuber; Nigel W Bunnett; Eileen F Grady; Karl Messlinger
Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: differences between peripheral and central CGRP receptor distribution.
The Journal of comparative neurology 2008;507(3):1277-99.
2008: Hongying Wang; Shoubin Wen; Nigel W Bunnett; Richard Leduc; Morley D Hollenberg; Wallace K MacNaughton
Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein.
The Journal of biological chemistry 2008;283(2):809-15.
2007: Benjamin Padilla; Graeme S Cottrell; Dirk Roosterman; Stella Pikios; Laurent Muller; Martin Steinhoff; Nigel W Bunnett
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins.
The Journal of cell biology 2007;179(5):981-97.
2007: Victoria M Shpacovitch; M Feld; Nigel W Bunnett; Martin Steinhoff
Protease-activated receptors: novel PARtners in innate immunity.
Trends in immunology 2007;28(12):541-50.
2007: Burcu Hasdemir; Nigel W Bunnett; Graeme S Cottrell
Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor.
The Journal of biological chemistry 2007;282(40):29646-57.
2007: Wolfgang Knecht; Graeme S Cottrell; Silvia Amadesi; Johanna Mohlin; Anita Skåregärde; Karin Gedda; Anders Peterson; Kevin Chapman; Morley D Hollenberg; Nathalie Vergnolle; Nigel W Bunnett
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
The Journal of biological chemistry 2007;282(36):26089-100.
2007: David Gazzieri; Marcello Trevisani; Jochen Springer; Selena Harrison; Graeme S Cottrell; Eunice Andre; Paola Nicoletti; Daniela Massi; Sandra Zecchi; Daniele Nosi; Marco Santucci; Norma P Gerard; Monica Lucattelli; Giuseppe Lungarella; Axel Fischer; Eileen F Grady; Nigel W Bunnett; Pierangelo Geppetti
Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury.
Free radical biology & medicine 2007;43(4):581-9.
2007: Marcello Trevisani; Jan Siemens; Serena Materazzi; Diana M Bautista; Romina Nassini; Barbara Campi; Noritaka Imamachi; Eunice Andrè; Riccardo Patacchini; Graeme S Cottrell; Raffaele Gatti; Allan I Basbaum; Nigel W Bunnett; David Julius; Pierangelo Geppetti
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13519-24.
2007: Juan Carlos G Marvizón; O A Pérez; Bingbing Song; W Chen; Nigel W Bunnett; Eileen F Grady; A J Todd
Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors.
Neuroscience 2007;148(1):250-65.
2007: Dirk Roosterman; Graeme S Cottrell; Benjamin Padilla; Laurent Muller; Christopher B Eckman; Nigel W Bunnett; Martin Steinhoff
Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11838-43.
2007: Jacob G Kirkland; Graeme S Cottrell; Nigel W Bunnett; Carlos U Corvera
Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G335-46.
2007: Graeme S Cottrell; Silvia Amadesi; Stella Pikios; Eric Camerer; J Adam Willardsen; Brett R Murphy; George H Caughey; Paul wolters; Shaun R Coughlin; Anders Peterson; Wolfgang Knecht; Charalabos Pothoulakis; Nigel W Bunnett; Eileen F Grady
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Gastroenterology 2007;132(7):2422-37.
2007: Ahmed Kayssi; Silvia Amadesi; Francisco Bautista; Nigel W Bunnett; Stephen Vanner
Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon.
The Journal of physiology 2007;580(Pt.3):977-91.
2007: Graeme S Cottrell; Benjamin Padilla; Stella Pikios; Dirk Roosterman; Martin Steinhoff; Eileen F Grady; Nigel W Bunnett
Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1.
The Journal of biological chemistry 2007;282(16):12260-71.
2007: Nicolas Cenac; Christopher N Andrews; Marinella Holzhausen; Kevin Chapman; Graeme S Cottrell; Patricia Andrade-Gordon; Martin Steinhoff; Giovanni Barbara; Paul Beck; Nigel W Bunnett; Keith Sharkey; Jose Geraldo P Ferraz; Eldon A Shaffer; Nathalie Vergnolle
Role for protease activity in visceral pain in irritable bowel syndrome.
The Journal of clinical investigation 2007;117(3):636-47.
2007: Dirk Roosterman; Oliver J Kreuzer; Nicole Brune; Graeme S Cottrell; Nigel W Bunnett; Wolfgang Meyerhof; Martin Steinhoff
Agonist-induced endocytosis of rat somatostatin receptor 1.
Endocrinology 2007;148(3):1050-8.
2007: Andrew D Grant; Graeme S Cottrell; Silvia Amadesi; Marcello Trevisani; Paola Nicoletti; Serena Materazzi; Christophe Altier; Nicolas Cenac; Gerald W Zamponi; Francisco Bautista-Cruz; Carlos Barajas Lopez; Elizabeth K Joseph; Jon D Levine; Wolfgang Liedtke; Stephen Vanner; Nathalie Vergnolle; Pierangelo Geppetti; Nigel W Bunnett
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
The Journal of physiology 2007;578(Pt 3):715-33.
2007: Giovanni Barbara; Bingxian Wang; Vincenzo Stanghellini; Roberto De Giorgio; Cesare Cremon; Giovanni Di Nardo; Marcello Trevisani; Barbara Campi; Pierangelo Geppetti; Marcello Tonini; Nigel W Bunnett; David Grundy; Roberto Corinaldesi
Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome.
Gastroenterology 2007;132(1):26-37.
2006: Katerina Oikonomopoulou; Kristina K Hansen; Mahmoud Saifeddine; Illa Tea; Michael Blaber; Sachiko I Blaber; Isobel A Scarisbrick; Patricia Andrade-Gordon; Graeme S Cottrell; Nigel W Bunnett; Eleftherios P Diamandis; Morley D Hollenberg
Proteinase-activated receptors, targets for kallikrein signaling.
The Journal of biological chemistry 2006;281(43):32095-112.
2006: Dirk Roosterman; Tobias Goerge; Stefan W Schneider; Nigel W Bunnett; Martin Steinhoff
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ.
Physiological reviews 2006;86(4):1309-79.
2006: Graeme S Cottrell; Benjamin Padilla; Stella Pikios; Dirk Roosterman; Martin Steinhoff; Daphne Gehringer; Eileen F Grady; Nigel W Bunnett
Ubiquitin-dependent down-regulation of the neurokinin-1 receptor.
The Journal of biological chemistry 2006;281(38):27773-83.
2006: Silvia Amadesi; Graeme S Cottrell; Lorna Divino; Kevin Chapman; Eileen F Grady; Francisco Bautista; Rustum Karanjia; Carlos Barajas-Lopez; Stephen Vanner; Nathalie Vergnolle; Nigel W Bunnett
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
The Journal of physiology 2006;575(Pt 2):555-71.
2006: Raffaele Gatti; Eunice Andre; Silvia Amadesi; Thai Q Dinh; Axel Fischer; Nigel W Bunnett; Selena Harrison; Pierangelo Geppetti; Marcello Trevisani
Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;101(2):506-11.
2006: Nathalie Vergnolle; Laurie Cellars; Andrea Mencarelli; Giovanni Rizzo; Sunita Swaminathan; Paul Beck; Martin Steinhoff; Patricia Andrade-Gordon; Nigel W Bunnett; Morley D Hollenberg; John L Wallace; Giuseppe Cirino; Stefano Fiorucci
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
The Journal of clinical investigation 2006;116(7):2056.
2006: Elizabeth C Wick; Steven G Hoge; Sarah W Grahn; Edward Kim; Lorna A Divino; Eileen F Grady; Nigel W Bunnett; Kimberly S Kirkwood
Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(5):G959-69.
2006: Nigel W Bunnett
Protease-activated receptors: how proteases signal to cells to cause inflammation and pain.
Seminars in thrombosis and hemostasis 2006;32 Suppl 1():39-48.
2006: Hikma Boutaghou-Cherid; Christophe Porcher; Martine Liberge; Yvon Jule; Nigel W Bunnett; Marie-Odile Christen
Expression of the neurokinin type 1 receptor in the human colon.
Autonomic neuroscience : basic & clinical 2006;124(1-2):9-17.
2005: Graeme S Cottrell; Dirk Roosterman; Juan Carlos G Marvizon; Bingbing Song; Elizabeth C Wick; Stella Pikios; Helen Wong; Claire Berthelier; Yat Tang; Catia Sternini; Nigel W Bunnett; Eileen F Grady
Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat.
The Journal of comparative neurology 2005;490(3):239-55.
2005: Claire Jacob; Ping-Chang Yang; Dalila Darmoul; Silvia Amadesi; Toshiyuki Saito; Graeme S Cottrell; Anne-Marie Coelho; Pamela Singh; Eileen F Grady; Mary Perdue; Nigel W Bunnett
Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.
The Journal of biological chemistry 2005;280(36):31936-48.
2005: Amy Lightner Day; Elizabeth C Wick; Thomas H Jordan; Colleen E Jaffray; Nigel W Bunnett; Eileen F Grady; Kimberly S Kirkwood
Neutral endopeptidase determines the severity of pancreatitis-associated lung injury.
The Journal of surgical research 2005;128(1):21-7.
2005: Nigel W Bunnett
The stressed gut: contributions of intestinal stress peptides to inflammation and motility.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7409-10.
2005: Sophie Dulon; Dominique Leduc; Graeme S Cottrell; Jacques d'Alayer; Kristina K Hansen; Nigel W Bunnett; Morley D Hollenberg; Dominique Pidard; Michel Chignard
Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells.
American journal of respiratory cell and molecular biology 2005;32(5):411-9.
2005: Claire Jacob; Graeme S Cottrell; Daphne Gehringer; Fabien Schmidlin; Eileen F Grady; Nigel W Bunnett
c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2.
The Journal of biological chemistry 2005;280(16):16076-87.
2005: Matthew M Hutter; Elizabeth C Wick; Amy Lightner Day; John Maa; Elena C Zerega; Alec C Richmond; Thomas H Jordan; Eileen F Grady; Sean J Mulvihill; Nigel W Bunnett; Kimberly S Kirkwood
Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R).
Pancreas 2005;30(3):260-5.
2005: Toshiyuki Saito; Nigel W Bunnett
Protease-activated receptors: regulation of neuronal function.
Neuromolecular medicine 2005;7(1-2):79-99.
2004: Nathalie Vergnolle; Laurie Cellars; Andrea Mencarelli; Giovanni Rizzo; Sunita Swaminathan; Paul Beck; Martin Steinhoff; Patricia Andrade-Gordon; Nigel W Bunnett; Morley D Hollenberg; John L Wallace; Giuseppe Cirino; Stefano Fiorucci
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
The Journal of clinical investigation 2004;114(10):1444-56.
2004: Dirk Roosterman; Graeme S Cottrell; Fabien Schmidlin; Martin Steinhoff; Nigel W Bunnett
Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases.
The Journal of biological chemistry 2004;279(29):30670-9.
2004: Thomas E Scholzen; Martin Steinhoff; Anca Sindrilaru; Agatha Schwarz; Nigel W Bunnett; Thomas A Luger; Cheryl A Armstrong; John C Ansel
Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(9):1007-9.
2004: Silvia Amadesi; Jingjiang Nie; Nathalie Vergnolle; Graeme S Cottrell; Eileen F Grady; Marcello Trevisani; Chiara Manni; Pierangelo Geppetti; James A McRoberts; Helena S Ennes; John B Davis; Emeran Mayer; Nigel W Bunnett
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(18):4300-12.
2004: Graeme S Cottrell; Silvia Amadesi; Eileen F Grady; Nigel W Bunnett
Trypsin IV, a novel agonist of protease-activated receptors 2 and 4.
The Journal of biological chemistry 2004;279(14):13532-9.
2004: Valeria S Ossovskaya; Nigel W Bunnett
Protease-activated receptors: contribution to physiology and disease.
Physiological reviews 2004;84(2):579-621.
2004: Giovanni Barbara; Vincenzo Stanghellini; Roberto De Giorgio; Cesare Cremon; Graeme S Cottrell; Daniele Santini; Gianandrea Pasquinelli; Antonio Maria Morselli-Labate; Eileen F Grady; Nigel W Bunnett; Stephen Collins; Roberto Corinaldesi
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.
Gastroenterology 2004;126(3):693-702.
2003: Graeme S Cottrell; Silvia Amadesi; Fabien Schmidlin; Nigel W Bunnett
Protease-activated receptor 2: activation, signalling and function.
Biochemical Society transactions 2003;31(Pt 6):1191-7.
2003: Anthony J Kirkup; Wen Jiang; Nigel W Bunnett; David Grundy
Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats.
The Journal of physiology 2003;552(Pt 2):589-601.
2003: Stephan Seeliger; Claudia K Derian; Nathalie Vergnolle; Nigel W Bunnett; Roman Nawroth; Martin Schmelz; Pierre-Yves von der Weid; Jörg Buddenkotte; Cord Sunderkötter; Dieter Metze; Patricia Andrade-Gordon; Erik Harms; Dietmar Vestweber; Thomas A Luger; Martin Steinhoff
Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1871-85.
2003: Giovanni Barbara; Roberto De Giorgio; Vincenzo Stanghellini; Roberto Corinaldesi; Cesare Cremon; NP Gerard; C Gerard; Eileen F Grady; Nigel W Bunnett; Patricia Blennerhassett; Stephen Collins
Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse.
Gut 2003;52(10):1457-64.
2003: Fabien Schmidlin; Dirk Roosterman; Nigel W Bunnett
The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins.
American journal of physiology. Cell physiology 2003;285(4):C945-58.
2003: Cathy Nguyen; Anne-Marie Coelho; Eileen F Grady; Steven J Compton; John L Wallace; Morley D Hollenberg; Nicolas Cenac; Rafael Garcia-Villar; Lionel Bueno; Martin Steinhoff; Nigel W Bunnett; Nathalie Vergnolle
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
Canadian journal of physiology and pharmacology 2003;81(9):920-7.
2003: Marcello Trevisani; Silvia Amadesi; Fabien Schmidlin; Maria T Poblete; Elisabetta Bardella; Barbara Maggiore; Selena Harrison; Carlos D Figueroa; Michele Tognetto; Giuseppe Navarra; Alessandro Turini; Nigel W Bunnett; Pierangelo Geppetti; Roberto De Giorgio
Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro.
Gastroenterology 2003;125(1):126-35.
2003: Dirk Roosterman; Fabien Schmidlin; Nigel W Bunnett
Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2.
American journal of physiology. Cell physiology 2003;284(5):C1319-29.
2003: Nicolas Cenac; Rafael Garcia-Villar; Laurent Ferrier; Muriel Larauche; Nathalie Vergnolle; Nigel W Bunnett; Anne-Marie Coelho; Jean Fioramonti; Lionel Bueno
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4296-300.
2003: Anne-Marie Coelho; Valeria Ossovskaya; Nigel W Bunnett
Proteinase-activated receptor-2: physiological and pathophysiological roles.
Current medicinal chemistry. Cardiovascular and hematological agents 2003;1(1):61-72.
2003: Sophie Dulon; Céline Candé; Nigel W Bunnett; Morley D Hollenberg; Michel Chignard; Dominique Pidard
Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.
American journal of respiratory cell and molecular biology 2003;28(3):339-46.
2003: David E Reed; Carlos Barajas-Lopez; Graeme S Cottrell; Sara Velazquez-Rocha; Olivier Dery; Eileen F Grady; Nigel W Bunnett; Stephen Vanner
Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons.
The Journal of physiology 2003;547(Pt 2):531-42.
2003: Roland Lang; Peter I Song; Franz J Legat; Robert M Lavker; Brad Harten; Henner Kalden; Eileen F Grady; Nigel W Bunnett; Cheryl A Armstrong; John C Ansel
Human corneal epithelial cells express functional PAR-1 and PAR-2.
Investigative ophthalmology & visual science 2003;44(1):99-105.
2002: Nicolas Cenac; Anne-Marie Coelho; Cathy Nguyen; Steven Compton; Patricia Andrade-Gordon; Wallace K MacNaughton; John L Wallace; Morley D Hollenberg; Nigel W Bunnett; Rafael Garcia-Villar; Lionel Bueno; Nathalie Vergnolle
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
The American journal of pathology 2002;161(5):1903-15.
2002: Fabien Schmidlin; Silvia Amadesi; Karim Dabbagh; David E Lewis; Patrick Knott; Nigel W Bunnett; Paul R Gater; Pierangelo Geppetti; Claude Bertrand; Mary E Stevens
Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5315-21.
2002: Joseph R Reeve; Douglas C McVey; Nigel W Bunnett; Travis E Solomon; David A Keire; Fang-Jen Ho; Michael T Davis; Terry D Lee; John E Shively; Steven R Vigna
Differences in receptor binding and stability to enzymatic digestion between CCK-8 and CCK-58.
Pancreas 2002;25(3):e50-5.
2002: Michelle L Spenny; Pornprom Muangman; Stephen R Sullivan; Nigel W Bunnett; John C Ansel; John E Olerud; Nicole S Gibran
Neutral endopeptidase inhibition in diabetic wound repair.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2002;10(5):295-301.
2002: Amy M Lightner; Thomas H Jordan; Nigel W Bunnett; Eileen F Grady; Kimberly S Kirkwood
Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury.
Surgery 2002;132(2):193-9.
2002: Fabien Schmidlin; Olivier Déry; Nigel W Bunnett; Eileen F Grady
Heterologous regulation of trafficking and signaling of G protein-coupled receptors: beta-arrestin-dependent interactions between neurokinin receptors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3324-9.
2002: Victoria M Shpacovitch; Thomas Brzoska; Jörg Buddenkotte; Christopher Stroh; Christian P Sommerhoff; John C Ansel; Klaus Schulze-Osthoff; Nigel W Bunnett; Thomas A Luger; Martin Steinhoff
Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells.
The Journal of investigative dermatology 2002;118(2):380-5.
2002: Diego Miotto; M D Hollenberg; Nigel W Bunnett; Alberto Papi; Fausto Braccioni; Piera Boschetto; Federico Rea; Andrea Zuin; Pierangelo Geppetti; Marina Saetta; Piero Maestrelli; Leonardo M Fabbri; Cristina E Mapp
Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers.
Thorax 2002;57(2):146-51.
2002: Graeme S Cottrell; Anne-Marie Coelho; Nigel W Bunnett
Protease-activated receptors: the role of cell-surface proteolysis in signalling.
Essays in biochemistry 2002;38():169-83.
2001: Fabien Schmidlin; Nigel W Bunnett
Protease-activated receptors: how proteases signal to cells.
Current opinion in pharmacology 2001;1(6):575-82.
2001: Fabien Schmidlin; Silvia Amadesi; R Vidil; Marcello Trevisani; N Martinet; George H Caughey; Michele Tognetto; Giorgio Cavallesco; Cristina E Mapp; Pierangelo Geppetti; Nigel W Bunnett
Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle.
American journal of respiratory and critical care medicine 2001;164(7):1276-81.
2001: Nigel W Bunnett
Pharmacological modulation of skin neuromediators (PAR II).
Experimental dermatology 2001;10(5):354-5.
2001: Lawrence de Garavilla; Nathalie Vergnolle; Steven H Young; Helena S Ennes; Martin Steinhoff; V S Ossovskaya; Michael R D'Andrea; Emeran Mayer; J L Wallace; MD Hollenberg; Patricia Andrade-Gordon; Nigel W Bunnett
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism.
British journal of pharmacology 2001;133(7):975-87.
2001: Kimberly S Kirkwood; Nigel W Bunnett; John Maa; I Castagliolo; B Liu; N Gerard; J Zacks; Charalabos Pothoulakis; Eileen F Grady
Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(2):G544-51.
2001: Fabien Schmidlin; O Dery; Kathryn DeFea; L Slice; Simona Patierno; Catia Sternini; Eileen F Grady; Nigel W Bunnett
Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor.
The Journal of biological chemistry 2001;276(27):25427-37.
2001: Nathalie Vergnolle; Nigel W Bunnett; Keith Sharkey; Valentine Brussee; Steven J Compton; Eileen F Grady; Giuseppe Cirino; N Gerard; A I Basbaum; Patricia Andrade-Gordon; Morley D Hollenberg; John L Wallace
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.
Nature medicine 2001;7(7):821-6.
2001: James A McRoberts; Santosh V Coutinho; Juan Carlos G Marvizón; Eileen F Grady; Michele Tognetto; J N Sengupta; Helena S Ennes; Victor Chaban; Silvia Amadesi; Christophe Creminon; T Lanthorn; Pierangelo Geppetti; Nigel W Bunnett; Emeran Mayer
Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats.
Gastroenterology 2001;120(7):1737-48.
2001: Olivier Déry; Kathryn DeFea; Nigel W Bunnett
Protein kinase C-mediated desensitization of the neurokinin 1 receptor.
American journal of physiology. Cell physiology 2001;280(5):C1097-106.
2001: Nathalie Vergnolle; John L Wallace; Nigel W Bunnett; Morley D Hollenberg
Protease-activated receptors in inflammation, neuronal signaling and pain.
Trends in pharmacological sciences 2001;22(3):146-52.
2001: Oliver J Kreuzer; B Krisch; O Déry; Nigel W Bunnett; Wolfgang Meyerhof
Agonist-mediated endocytosis of rat somatostatin receptor subtype 3 involves beta-arrestin and clathrin coated vesicles.
Journal of neuroendocrinology 2001;13(3):279-87.
2001: Monica C Chen; J Goliger; Nigel W Bunnett; Andrew H Soll
Apical and basolateral EGF receptors regulate gastric mucosal paracellular permeability.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(2):G264-72.
2001: Thomas E Scholzen; Martin Steinhoff; Paola Bonaccorsi; R Klein; Silvia Amadesi; P Geppetti; B Lu; N P Gerard; John E Olerud; Thomas A Luger; Nigel W Bunnett; Eileen F Grady; Cheryl A Armstrong; John C Ansel
Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1285-91.
2000: K Q Lindsey; S Wright Caughman; John E Olerud; Nigel W Bunnett; Cheryl A Armstrong; John C Ansel
Neural regulation of endothelial cell-mediated inflammation.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2000;5(1):74-8.
2000: Michele Tognetto; Marcello Trevisani; Barbara Maggiore; Giuseppe Navarra; Alessandro Turini; Remo Guerrini; Nigel W Bunnett; Pierangelo Geppetti; Selena Harrison
Evidence that PAR-1 and PAR-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder.
British journal of pharmacology 2000;131(4):689-94.
2000: John Maa; Eileen F Grady; Edward H Kim; SK Yoshimi; Matthew M Hutter; Nigel W Bunnett; Kimberly S Kirkwood
NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(4):G726-32.
2000: Kathryn DeFea; Z D Vaughn; E M O'Bryan; D Nishijima; Olivier Déry; Nigel W Bunnett
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):11086-91.
2000: John Maa; Eileen F Grady; SK Yoshimi; T E Drasin; Edward H Kim; Matthew M Hutter; Nigel W Bunnett; Kimberly S Kirkwood
Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice.
Surgery 2000;128(2):232-9.
2000: Eileen F Grady; SK Yoshimi; John Maa; D Valeroso; R K Vartanian; S Rahim; Edward H Kim; C Gerard; N Gerard; Nigel W Bunnett; Kimberly S Kirkwood
Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice.
British journal of pharmacology 2000;130(3):505-12.
2000: Fabio L M Ricciardolo; Martin Steinhoff; Silvia Amadesi; Remo Guerrini; Michele Tognetto; Marcello Trevisani; Christophe Creminon; C Bertrand; Nigel W Bunnett; Leonardo M Fabbri; Severo Salvadori; Pierangelo Geppetti
Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways.
American journal of respiratory and critical care medicine 2000;161(5):1672-80.
2000: Kathryn DeFea; J Zalevsky; MS Thoma; Olivier Déry; Dyche R D Mullins; Nigel W Bunnett
beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.
The Journal of cell biology 2000;148(6):1267-81.
2000: IS Song; Nigel W Bunnett; John E Olerud; Brad Harten; M Steinhoff; J R Brown; K J Sung; Cheryl A Armstrong; John C Ansel
Substance P induction of murine keratinocyte PAM 212 interleukin 1 production is mediated by the neurokinin 2 receptor (NK-2R).
Experimental dermatology 2000;9(1):42-52.
2000: Martin Steinhoff; Nathalie Vergnolle; Steven H Young; Michele Tognetto; Silvia Amadesi; Helena S Ennes; Marcello Trevisani; MD Hollenberg; J L Wallace; George H Caughey; S E Mitchell; L M Williams; Pierangelo Geppetti; Emeran Mayer; Nigel W Bunnett
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.
Nature medicine 2000;6(2):151-8.
2000: Kathryn DeFea; Fabien Schmidlin; Olivier Déry; Eileen F Grady; Nigel W Bunnett
Mechanisms of initiation and termination of signalling by neuropeptide receptors: a comparison with the proteinase-activated receptors.
Biochemical Society transactions 2000;28(4):419-26.
1999: KL Quinlan; Shubhada M Naik; G Cannon; Cheryl A Armstrong; Nigel W Bunnett; John C Ansel; S Wright Caughman
Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5656-65.
1999: S Sturiale; Giovanni Barbara; B Qiu; M Figini; Pierangelo Geppetti; NP Gerard; C Gerard; Eileen F Grady; Nigel W Bunnett; Stephen Collins
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11653-8.
1999: Kimberly S Kirkwood; Edward H Kim; X D He; E Q Calaustro; C Domush; SK Yoshimi; Eileen F Grady; John Maa; Nigel W Bunnett; H T Debas
Substance P inhibits pancreatic exocrine secretion via a neural mechanism.
The American journal of physiology 1999;277(2 Pt 1):G314-20.
1999: Martin Steinhoff; Carlos U Corvera; MS Thoma; W Kong; Barbara McAlpine; George H Caughey; John C Ansel; Nigel W Bunnett
Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.
Experimental dermatology 1999;8(4):282-94.
1999: Olivier Déry; MS Thoma; H Wong; Eileen F Grady; Nigel W Bunnett
Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor.
The Journal of biological chemistry 1999;274(26):18524-35.
1999: Carlos U Corvera; Olivier Déry; K McConalogue; P Gamp; MS Thoma; B Al-Ani; George H Caughey; MD Hollenberg; Nigel W Bunnett
Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.
The Journal of physiology 1999;517 ( Pt 3)():741-56.
1999: K McConalogue; Olivier Déry; M Lovett; H Wong; J H Walsh; Eileen F Grady; Nigel W Bunnett
Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor.
The Journal of biological chemistry 1999;274(23):16257-68.
1999: K McConalogue; Eileen F Grady; JG Minnis; Barbara Balestra; Marcello Tonini; Nicholas Brecha; Nigel W Bunnett; Catia Sternini
Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2.
Neuroscience 1999;90(3):1051-9.
1999: Olivier Déry; Nigel W Bunnett
Proteinase-activated receptors: a growing family of heptahelical receptors for thrombin, trypsin and tryptase.
Biochemical Society transactions 1999;27(2):246-54.
1999: Juan Carlos G Marvizón; Eileen F Grady; E Stefani; Nigel W Bunnett; Emeran Mayer
Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABA(B) receptors.
The European journal of neuroscience 1999;11(2):417-26.
1999: KL Quinlan; IS Song; Shubhada M Naik; E L Letran; John E Olerud; Nigel W Bunnett; Cheryl A Armstrong; S Wright Caughman; John C Ansel
VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance P.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1656-61.
1999: Peter Baluk; Gavin Thurston; TJ Murphy; Nigel W Bunnett; Donald M McDonald
Neurogenic plasma leakage in mouse airways.
British journal of pharmacology 1999;126(2):522-8.
1998: KL Quinlan; IS Song; Nigel W Bunnett; E Letran; M Steinhoff; Brad Harten; John E Olerud; Cheryl A Armstrong; S Wright Caughman; John C Ansel
Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function.
The American journal of physiology 1998;275(6 Pt 1):C1580-90.
1998: Nigel W Bunnett; M Bouvier; A De Blasi
Peptide G protein-coupled receptors meet at Erice.
Trends in pharmacological sciences 1998;19(9):343-6.
1998: K McConalogue; Carlos U Corvera; P D Gamp; Eileen F Grady; Nigel W Bunnett
Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2.
Molecular biology of the cell 1998;9(8):2305-24.
1998: Olivier Déry; Carlos U Corvera; Martin Steinhoff; Nigel W Bunnett
Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.
The American journal of physiology 1998;274(6 Pt 1):C1429-52.
1998: Costanza Emanueli; Eileen F Grady; Paolo Madeddu; M Figini; Nigel W Bunnett; D Parisi; Domenico Regoli; Pierangelo Geppetti
Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.
Hypertension 1998;31(6):1299-304.
1998: K McConalogue; Nigel W Bunnett
G protein-coupled receptors in gastrointestinal physiology. II. Regulation of neuropeptide receptors in enteric neurons.
The American journal of physiology 1998;274(5 Pt 1):G792-6.
1998: Thomas E Scholzen; Cheryl A Armstrong; Nigel W Bunnett; Thomas A Luger; John E Olerud; John C Ansel
Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems.
Experimental dermatology 1998;7(2-3):81-96.
1997: Juan Carlos G Marvizón; V Martínez; Eileen F Grady; Nigel W Bunnett; Emeran Mayer
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8129-36.
1997: Carlos U Corvera; Olivier Déry; K McConalogue; Stephan Böhm; LM Khitin; George H Caughey; DG Payan; Nigel W Bunnett
Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.
The Journal of clinical investigation 1997;100(6):1383-93.
1997: Beverley A Moore; Stephen Vanner; Nigel W Bunnett; Keith Sharkey
Characterization of neurokinin-1 receptors in the submucosal plexus of guinea pig ileum.
The American journal of physiology 1997;273(3 Pt 1):G670-8.
1997: Eileen F Grady; Stephan Böhm; Nigel W Bunnett
Turning off the signal: mechanisms that attenuate signaling by G protein-coupled receptors.
The American journal of physiology 1997;273(3 Pt 1):G586-601.
1997: W Kong; K McConalogue; LM Khitin; MD Hollenberg; DG Payan; Stephan Böhm; Nigel W Bunnett
Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8884-9.
1997: Eileen F Grady; Stephan Böhm; K McConalogue; A Garland; John C Ansel; John E Olerud; Nigel W Bunnett
Mechanisms attenuating cellular responses to neuropeptides: extracellular degradation of ligands and desensitization of receptors.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1997;2(1):69-75.
1997: John C Ansel; Cheryl A Armstrong; I Song; KL Quinlan; John E Olerud; S Wright Caughman; Nigel W Bunnett
Interactions of the skin and nervous system.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1997;2(1):23-6.
1997: B Lu; M Figini; Costanza Emanueli; Pierangelo Geppetti; Eileen F Grady; NP Gerard; J Ansell; DG Payan; C Gerard; Nigel W Bunnett
The control of microvascular permeability and blood pressure by neutral endopeptidase.
Nature medicine 1997;3(8):904-7.
1997: Eugene D Jacobson; Nigel W Bunnett
G protein-coupled receptor signaling: implications for the digestive system.
Digestive diseases (Basel, Switzerland) 1997;15(4-5):207-42.
1997: M Figini; Costanza Emanueli; Eileen F Grady; Kimberly S Kirkwood; DG Payan; John C Ansel; C Gerard; Pierangelo Geppetti; Nigel W Bunnett
Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas.
The American journal of physiology 1997;272(4 Pt 1):G785-93.
1997: Stephan Böhm; LM Khitin; S P Smeekens; Eileen F Grady; DG Payan; Nigel W Bunnett
Identification of potential tyrosine-containing endocytic motifs in the carboxyl-tail and seventh transmembrane domain of the neurokinin 1 receptor.
The Journal of biological chemistry 1997;272(4):2363-72.
1996: Eileen F Grady; P D Gamp; E Jones; Peter Baluk; Donald M McDonald; DG Payan; Nigel W Bunnett
Endocytosis and recycling of neurokinin 1 receptors in enteric neurons.
Neuroscience 1996;75(4):1239-54.
1996: A L Portbury; John B Furness; Bridget R Southwell; H Wong; J H Walsh; Nigel W Bunnett
Distribution of neurokinin-2 receptors in the guinea-pig gastrointestinal tract.
Cell and tissue research 1996;286(3):281-92.
1996: Nigel W Bunnett; DG Payan; Eileen F Grady
Detection of naturally expressed receptors for gastrin-releasing peptide and tachykinins using cyanine 3-labelled neuropeptides.
The Histochemical journal 1996;28(11):811-26.
1996: Eileen F Grady; Peter Baluk; Stephan Böhm; P D Gamp; H Wong; DG Payan; John C Ansel; A L Portbury; John B Furness; Donald M McDonald; Nigel W Bunnett
Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(21):6975-86.
1996: Stephan Böhm; LM Khitin; Eileen F Grady; G Aponte; DG Payan; Nigel W Bunnett
Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.
The Journal of biological chemistry 1996;271(36):22003-16.
1996: Stephan Böhm; W Kong; D Bromme; S P Smeekens; D C Anderson; A Connolly; M Kahn; Nicolas Nelken; Shaun R Coughlin; DG Payan; Nigel W Bunnett
Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.
The Biochemical journal 1996;314 ( Pt 3)():1009-16.
1996: A M Garland; Eileen F Grady; M Lovett; S R Vigna; M M Frucht; J E Krause; Nigel W Bunnett
Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors.
Molecular pharmacology 1996;49(3):438-46.
1996: Donald M McDonald; J J Bowden; Peter Baluk; Nigel W Bunnett
Neurogenic inflammation. A model for studying efferent actions of sensory nerves.
Advances in experimental medicine and biology 1996;410():453-62.
1996: John C Ansel; A H Kaynard; Cheryl A Armstrong; John E Olerud; Nigel W Bunnett; D Payan
Skin-nervous system interactions.
The Journal of investigative dermatology 1996;106(1):198-204.
1995: Catia Sternini; D Su; P D Gamp; Nigel W Bunnett
Cellular sites of expression of the neurokinin-1 receptor in the rat gastrointestinal tract.
The Journal of comparative neurology 1995;358(4):531-40.
1995: Eileen F Grady; A M Garland; P D Gamp; M Lovett; DG Payan; Nigel W Bunnett
Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.
Molecular biology of the cell 1995;6(5):509-24.
1995: Eileen F Grady; L W Slice; W O Brant; John H Walsh; DG Payan; Nigel W Bunnett
Direct observation of endocytosis of gastrin releasing peptide and its receptor.
The Journal of biological chemistry 1995;270(9):4603-11.
1995: Nigel W Bunnett; Paul Dazin; DG Payan; Eileen F Grady
Characterization of receptors using cyanine 3-labeled neuropeptides.
Peptides 1995;16(4):733-40.
1994: A M Garland; Eileen F Grady; DG Payan; S R Vigna; Nigel W Bunnett
Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells.
The Biochemical journal 1994;303 ( Pt 1)():177-86.
1994: J J Bowden; A M Garland; Peter Baluk; P Lefevre; Eileen F Grady; S R Vigna; Nigel W Bunnett; Donald M McDonald
Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):8964-8.
1994: M A Miller; Nigel W Bunnett; H T Debas
Laminin mediates the restitution of rat gastric mucosa in vitro.
Experimental physiology 1994;79(5):647-59.
1994: L W Slice; H C Wong; Catia Sternini; Eileen F Grady; Nigel W Bunnett; John H Walsh
The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence.
The Journal of biological chemistry 1994;269(34):21755-61.
1994: A Okamoto; M Lovett; DG Payan; Nigel W Bunnett
Interactions between neutral endopeptidase (EC 3.4.24.11) and the substance P (NK1) receptor expressed in mammalian cells.
The Biochemical journal 1994;299 ( Pt 3)():683-93.
1994: J L Gray; Nigel W Bunnett; Susan L Orloff; Sean J Mulvihill; H T Debas
A role for calcitonin gene-related peptide in protection against gastric ulceration.
Annals of surgery 1994;219(1):58-64.
1993: O Huber; C Bertrand; Nigel W Bunnett; Carlos A Pellegrini; Jay A Nadel; H T Debas; P Geppetti
Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors.
Gastroenterology 1993;105(4):981-7.
1993: O Huber; C Bertrand; Nigel W Bunnett; Carlos A Pellegrini; Jay A Nadel; P Nakazato; H T Debas; P Geppetti
Tachykinins mediate contraction of the human lower esophageal sphincter in vitro via activation of NK2 receptors.
European journal of pharmacology 1993;239(1-3):103-9.
1993: L Hwang; R Leichter; A Okamoto; DG Payan; S M Collins; Nigel W Bunnett
Downregulation of neutral endopeptidase (EC 3.4.24.11) in the inflamed rat intestine.
The American journal of physiology 1993;264(4 Pt 1):G735-43.
1993: Nigel W Bunnett; V Wu; Catia Sternini; J Klinger; E Shimomaya; DG Payan; R Kobayashi; John H Walsh
Distribution and abundance of neutral endopeptidase (EC 3.4.24.11) in the alimentary tract of the rat.
The American journal of physiology 1993;264(3 Pt 1):G497-508.
1993: Z F Gu; D Menozzi; A Okamoto; P N Maton; Nigel W Bunnett
Neutral endopeptidase (EC 3.4.24.11) modulates the contractile effects of neuropeptides on muscle cells from the guinea-pig stomach.
Experimental physiology 1993;78(1):35-48.
1992: M S Gilbert; Nigel W Bunnett; DG Payan
Antibodies to the rat substance P receptor: production and characterization.
Cellular and molecular neurobiology 1992;12(6):529-45.
1992: H Terashima; A Okamoto; D Menozzi; Edward J Goetzl; Nigel W Bunnett
Identification of neuropeptide-degrading enzymes in the pancreas.
Peptides 1992;13(4):741-8.
1992: H T Debas; M T Nelson; Nigel W Bunnett; Sean J Mulvihill
Selective release of somatostatin by calcitonin gene-related peptide and influence on pancreatic secretion.
Annals of the New York Academy of Sciences 1992;657():289-98.
1992: H Terashima; H Wong; R Kobayashi; Nigel W Bunnett
Immunochemical localization of aminopeptidase M in the alimentary tract of the guinea pig and rat.
Gastroenterology 1992;102(6):1867-76.
1992: Z F Gu; Tapas K Pradhan; David H Coy; Samuel A Mantey; Nigel W Bunnett; Robert T Jensen; P N Maton
Actions of somatostatins on gastric smooth muscle cells.
The American journal of physiology 1992;262(3 Pt 1):G432-8.
1992: H Terashima; H T Debas; Nigel W Bunnett
Effects of cholecystokinin and gastrin antagonists on pancreatic exocrine secretion stimulated by gastrin-releasing peptide.
Pancreas 1992;7(2):212-9.
1992: Susan L Orloff; Nigel W Bunnett; John H Walsh; H T Debas
Intestinal acid inhibits gastric acid secretion by neural and hormonal mechanisms in rats.
The American journal of physiology 1992;262(1 Pt 1):G165-70.
1992: Nigel W Bunnett; S M Goldstein; P Nakazato
Isolation of a neuropeptide-degrading carboxypeptidase from the human stomach.
Gastroenterology 1992;102(1):76-87.
1991: S M Goldstein; J Leong; Nigel W Bunnett
Human mast cell proteases hydrolyze neurotensin, kinetensin and Leu5-enkephalin.
Peptides 1991;12(5):995-1000.
1991: D Menozzi; Z F Gu; P N Maton; Nigel W Bunnett
Inhibition of peptidases potentiates enkephalin-stimulated contraction of gastric muscle cells.
The American journal of physiology 1991;261(3 Pt 1):G476-84.
1991: Susan L Orloff; Nigel W Bunnett; H Wong; John H Walsh; H T Debas
Neural and hormonal mechanisms mediate the enterogastric reflex: a study in intestinal transplants in rats.
Gastroenterology 1991;101(3):734-42.
1991: M Katayama; Jay A Nadel; Nigel W Bunnett; G U Di Maria; M Haxhiu; D B Borson
Catabolism of calcitonin gene-related peptide and substance P by neutral endopeptidase.
Peptides 1991;12(3):563-7.
1991: Nigel W Bunnett; Sean J Mulvihill; H T Debas
Calcitonin gene-related peptide inhibits exocrine secretion from the rat pancreas by a neurally mediated mechanism.
Experimental physiology 1991;76(1):115-23.
1990: Sean J Mulvihill; Nigel W Bunnett; Y Goto; H T Debas
Somatostatin inhibits pancreatic exocrine secretion via a neural mechanism.
Metabolism: clinical and experimental 1990;39(9 Suppl 2):143-8.
1990: Nigel W Bunnett; william helton; H T Debas; J W Ensinck
CGRP stimulates the release of pro-somatostatin-derived peptides from the gastric fundus.
The American journal of physiology 1990;258(2 Pt 1):G316-9.
1990: Nigel W Bunnett; John H Walsh; H T Debas
Metabolism of enkephalin in stomach wall of rats.
The American journal of physiology 1990;258(1 Pt 1):G143-51.
1989: Nigel W Bunnett; A J Turner; H T Debas
Metabolism and inactivation of gastrin releasing peptide by endopeptidase-24.11 in the dog.
Quarterly journal of experimental physiology (Cambridge, England) 1989;74(5):727-34.
1987: Nigel W Bunnett
The role of neuropeptides in regulating airway function. Postsecretory metabolism of peptides.
The American review of respiratory disease 1987;136(6 Pt 2):S27-34.