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Holger Heine

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Christine Warmbold; Holger Heine; Arnd Petersen; Fiorentina Rus; Neal Silverman; Roland Suck; Karin Uliczka; Artur J Ulmer; Thomas Roeder
Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster.
Lore Brade; Franco Di Padova; Holger Heine; Gracjana Klein; Helmut Brade; Satish Raina; Sven Müller-Loennies
Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.
Kimberley Kallsen; Ellen Andresen; Holger Heine
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells.

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2013: Christine Warmbold; Holger Heine; Arnd Petersen; Fiorentina Rus; Neal Silverman; Roland Suck; Karin Uliczka; Artur J Ulmer; Thomas Roeder
Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):366-71.
2012: Lore Brade; Franco Di Padova; Holger Heine; Gracjana Klein; Helmut Brade; Satish Raina; Sven Müller-Loennies
Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.
Innate immunity 2012;18(2):279-93.
2012: Kimberley Kallsen; Ellen Andresen; Holger Heine
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells.
PloS one 2012;7(11):e50000.
2011: Kathleen Fischer; Holger Heine; Buko Lindner; Karina Stein; Artur J Ulmer; Otto Holst
Cytokine-inducing lipoteichoic acids of the allergy-protective bacterium Lactococcus lactis G121 do not activate via Toll-like receptor 2.
Glycobiology 2011;21(12):1588-95.
2011: Holger Heine
TLRs, NLRs and RLRs: innate sensors and their impact on allergic diseases--a current view.
Immunology letters 2011;139(1-2):14-24.
2011: Nicolas Gisch; Birte Buske; Holger Heine; Buko Lindner; Ulrich Zähringer
Synthesis of biotinylated muramyl tripeptides with NOD2-stimulating activity.
Bioorganic & medicinal chemistry letters 2011;21(11):3362-6.
2011: Manuela Rossol; Matthew J Sweet; Holger Heine; Carina Klein; Undine Meusch; Dagmar Quandt; Sunna Hauschildt
LPS-induced cytokine production in human monocytes and macrophages.
Critical reviews in immunology 2011;31(5):379-446.
2011: Ellen Andresen; Jörn Bullwinkel; Gunar Günther; Christoph Lange; Holger Heine
Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease.
PloS one 2011;6(7):e21898.
2011: Ellen Andresen; Christoph Lange; Daniela Strodthoff; Torsten Goldmann; Nicole Fischer; Hany Sahly; Detlev Branscheid; Holger Heine
S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.
BMC pulmonary medicine 2011;11():10.
2010: J Debarry; A Hanuszkiewicz; K Stein; Otto Holst; Holger Heine
The allergy-protective properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharide.
Allergy 2010;65(6):690-7.
2009: Sabine Riekenberg; Katja Farhat; Jennifer Debarry; Holger Heine; Günther Jung; Karl-Heinz Wiesmüller; Artur J Ulmer
Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide.
The FEBS journal 2009;276(3):649-59.
2008: Hajo Haase; Julia L Ober-Blöbaum; Gabriela Engelhardt; Silke Hebel; Antje Heit; Holger Heine; Lothar Rink
Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6491-502.
2008: Kay Vogel; Nicole Blümer; Melanie Korthals; Jessica Mittelstädt; Holger Garn; Markus Ege; Erika von Mutius; Sören G Gatermann; Albrecht Bufe; Torsten Goldmann; Karin Schwaiger; Harald Renz; Sven Brandau; Johann Bauer; Holger Heine; Otto Holst
Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties.
The Journal of allergy and clinical immunology 2008;122(2):307-12, 312.e1-8.
2008: Katja Farhat; Sabine Riekenberg; Holger Heine; Jennifer Debarry; Roland Lang; Jörg Mages; Ute Buwitt-Beckmann; Kristina Röschmann; Günther Jung; Karl-Heinz Wiesmüller; Artur J Ulmer
Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.
Journal of leukocyte biology 2008;83(3):692-701.
2008: Anna Hanuszkiewicz; Göran Hübner; Evgeny Vinogradov; Buko Lindner; Lore Brade; Helmut Brade; Jennifer Debarry; Holger Heine; Otto Holst
Structural and immunochemical analysis of the lipopolysaccharide from Acinetobacter lwoffii F78 located outside Chlamydiaceae with a Chlamydia-specific lipopolysaccharide epitope.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(33):10251-8.
2008: Ulrich Zähringer; Buko Lindner; Seiichi Inamura; Holger Heine; Christian Alexander
TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity.
Immunobiology 2008;213(3-4):205-24.
2007: Verena von Bülow; Svenja Dubben; Gabriela Engelhardt; Silke Hebel; Birgit Plümäkers; Holger Heine; Lothar Rink; Hajo Haase
Zinc-dependent suppression of TNF-alpha production is mediated by protein kinase A-induced inhibition of Raf-1, I kappa B kinase beta, and NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):4180-6.
2007: Jennifer Debarry; Holger Garn; Anna Hanuszkiewicz; Nina Dickgreber; Nicole Blümer; Erika von Mutius; Albrecht Bufe; Sören G Gatermann; Harald Renz; Otto Holst; Holger Heine
Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties.
The Journal of allergy and clinical immunology 2007;119(6):1514-21.
2007: Silke Walter; Maryse Letiembre; Yang Liu; Holger Heine; Botond Penke; Wenlin Hao; Barbara Bode; Nicole Manietta; Jessica Walter; Walter Schulz-Schuffer; Klaus Fassbender
Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(6):947-56.
2007: Holger Heine; Sabine Gronow; Alla Zamyatina; kosma paul; Helmut Brade
Investigation on the agonistic and antagonistic biological activities of synthetic Chlamydia lipid A and its use in in vitro enzymatic assays.
Journal of endotoxin research 2007;13(2):126-32.
2006: Antje Blumenthal; Stefan Ehlers; Jörg Lauber; Jan Buer; Christoph Lange; Torsten Goldmann; Holger Heine; Ernst Brandt; Norbert Reiling
The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.
Blood 2006;108(3):965-73.
2006: Ingo Fricke; Daniell Mitchell; Jessica Mittelstädt; Nadine Lehan; Holger Heine; Torsten Goldmann; Andreas Böhle; Sven Brandau
Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5173-82.
2006: Ute Buwitt-Beckmann; Holger Heine; Karl-Heinz Wiesmüller; Günther Jung; Roland Brock; Shizuo Akira; Artur J Ulmer
TLR1- and TLR6-independent recognition of bacterial lipopeptides.
The Journal of biological chemistry 2006;281(14):9049-57.
2006: Stefan Löseke; Evelin Grage-Griebenow; Holger Heine; A Wagner; S Akira; S Bauer; Albrecht Bufe
In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells.
Scandinavian journal of immunology 2006;63(4):264-74.
2006: Jörg Andrä; Jörg Rademann; Jörg Howe; Michel H J Koch; Holger Heine; Ulrich Zähringer; Klaus Brandenburg
Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization.
Biological chemistry 2006;387(3):301-10.
2006: Seiichi Inamura; Yukari Fujimoto; Akiko Kawasaki; Zenyu Shiokawa; Eva Woelk; Holger Heine; Buko Lindner; Naohiro Inohara; Shoichi Kusumoto; Koichi Fukase
Synthesis of peptidoglycan fragments and evaluation of their biological activity.
Organic & biomolecular chemistry 2006;4(2):232-42.
2006: William Vermi; Fabio Facchetti; Elena Riboldi; Holger Heine; Sara Scutera; Sarah Stornello; Daniela Ravarino; Paola Cappello; Mirella Giovarelli; Raffaele Badolato; Mario Zucca; Francesca Gentili; Marco Chilosi; Claudio Doglioni; Alessandro Negro Ponzi; Silvano Sozzani; Tiziana Musso
Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma.
Blood 2006;107(2):454-62.
2005: Ute Buwitt-Beckmann; Holger Heine; Karl-Heinz Wiesmüller; Günther Jung; Roland Brock; Artur J Ulmer
Lipopeptide structure determines TLR2 dependent cell activation level.
The FEBS journal 2005;272(24):6354-64.
2005: Yang Liu; Silke Walter; Massimiliano Stagi; Dmitry Cherny; Maryse Letiembre; Walter Schulz-Schaeffer; Holger Heine; Botond Penke; Harald Neumann; Klaus Fassbender
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.
Brain : a journal of neurology 2005;128(Pt 8):1778-89.
2005: Maria Manukyan; Kathy Triantafilou; Martha Triantafilou; Alan Mackie; Nadra Nilsen; Terje Espevik; Karl-Heinz Wiesmüller; Artur J Ulmer; Holger Heine
Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.
European journal of immunology 2005;35(3):911-21.
2005: Holger Heine; Artur J Ulmer
Recognition of bacterial products by toll-like receptors.
Chemical immunology and allergy 2005;86():99-119.
2005: Ute Buwitt-Beckmann; Holger Heine; Karl-Heinz Wiesmüller; Günther Jung; Roland Brock; Shizuo Akira; Artur J Ulmer
Toll-like receptor 6-independent signaling by diacylated lipopeptides.
European journal of immunology 2005;35(1):282-9.
2004: Yingda Wu; Stefanie Adam; Lutz Hamann; Holger Heine; Artur J Ulmer; Ute Buwitt-Beckmann; Cordula Stamme
Accumulation of inhibitory kappaB-alpha as a mechanism contributing to the anti-inflammatory effects of surfactant protein-A.
American journal of respiratory cell and molecular biology 2004;31(6):587-94.
2004: Martha Triantafilou; Maria Manukyan; Alan Mackie; Siegfried Morath; Thomas Hartung; Holger Heine; Kathy Triantafilou
Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the Golgi are lipid raft-dependent.
The Journal of biological chemistry 2004;279(39):40882-9.
2004: Nicolas W J Schröder; Holger Heine; Christian Alexander; Maria Manukyan; Jana Eckert; Lutz Hamann; Ulf B Göbel; Ralf R Schumann
Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2683-91.
2004: Ulrich Zähringer; Buko Lindner; Yuriy A Knirel; Willem van den Akker; Rosemarie Hiestand; Holger Heine; Christoph Dehio
Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T.
The Journal of biological chemistry 2004;279(20):21046-54.
2004: Klaus Brandenburg; L Hawkins; Patrick Garidel; Jörg Andrä; Mareike Müller; Holger Heine; Michel H J Koch; Ulrich Seydel
Structural polymorphism and endotoxic activity of synthetic phospholipid-like amphiphiles.
Biochemistry 2004;43(13):4039-46.
2004: Oliver Umland; Holger Heine; Michaela Miehe; Kathleen Marienfeld; Karl H Staubach; Artur J Ulmer
Induction of various immune modulatory molecules in CD34(+) hematopoietic cells.
Journal of leukocyte biology 2004;75(4):671-9.
2003: Nicolas W J Schröder; Ursula Schombel; Holger Heine; Ulf B Göbel; Ulrich Zähringer; Ralf R Schumann
Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto.
The Journal of biological chemistry 2003;278(36):33645-53.
2003: Klaus Brandenburg; Frauke Wagner; Mareike Müller; Holger Heine; Jörg Andrä; Michel H J Koch; Ulrich Zähringer; Ulrich Seydel
Physicochemical characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans.
European journal of biochemistry / FEBS 2003;270(15):3271-9.
2003: Ulrich Seydel; Lynn Hawkins; Andra B Schromm; Holger Heine; Olaf Scheel; Michel H J Koch; Klaus Brandenburg
The generalized endotoxic principle.
European journal of immunology 2003;33(6):1586-92.
2003: Holger Heine; Volker El-Samalouti; Corinna Nötzel; Alexandra Pfeiffer; Arnd Lentschat; Shoichi Kusumoto; Gerd Schmitz; Lutz Hamann; Artur J Ulmer
CD55/decay accelerating factor is part of the lipopolysaccharide-induced receptor complex.
European journal of immunology 2003;33(5):1399-408.
2003: Holger Heine; Egil Lien
Toll-like receptors and their function in innate and adaptive immunity.
International archives of allergy and immunology 2003;130(3):180-92.
2003: Holger Heine; Sven Müller-Loennies; Lore Brade; Buko Lindner; Helmut Brade
Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC.
European journal of biochemistry / FEBS 2003;270(3):440-50.
2002: Stefanie Zeuke; Artur J Ulmer; Shoichi Kusumoto; Hugo A Katus; Holger Heine
TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS.
Cardiovascular research 2002;56(1):126-34.
2002: Jens Fleischer; Evelin Grage-Griebenow; Brigitte Kasper; Holger Heine; Martin Ernst; Ernst Brandt; Hans-Dieter Flad; Frank Petersen
Platelet factor 4 inhibits proliferation and cytokine release of activated human T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):770-7.
2002: Klaus Brandenburg; Motohiro Matsuura; Holger Heine; Mareike Müller; Makato Kiso; Hideharu Ishida; Michel H J Koch; Ulrich Seydel
Biophysical characterization of triacyl monosaccharide lipid a partial structures in relation to bioactivity.
Biophysical journal 2002;83(1):322-33.
2002: Holger Janusch; Lothar Brecker; Buko Lindner; Christian Alexander; Sabine Gronow; Holger Heine; Artur J Ulmer; Ernst Th Rietschel; Ulrich Zähringer
Structural and biological characterization of highly purified hepta-acyl lipid A present in the lipopolysaccharide of the Salmonella enterica sv. Minnesota Re deep rough mutant strain R595.
Journal of endotoxin research 2002;8(5):343-56.
2001: Alexandra Pfeiffer; Alfred Böttcher; Evelyn Orsó; M Kapinsky; Péter Nagy; Andrea Bodnár; Ingo Spreitzer; Gerhard Liebisch; Wolfgang Drobnik; K Gempel; M Horn; S Holmer; Thomas Hartung; G Multhoff; G Schütz; Hansgeorg Schindler; Artur J Ulmer; Holger Heine; Felix Stelter; Christine Schütt; Gregor Rothe; J Szöllôsi; Sándor Damjanovich; Gerd Schmitz
Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts.
European journal of immunology 2001;31(11):3153-64.
2001: Holger Heine; E T Rietschel; A J Ulmer
The biology of endotoxin.
Molecular biotechnology 2001;19(3):279-96.
2001: Andra B Schromm; Egil Lien; Philipp Henneke; J C Chow; A Yoshimura; Holger Heine; Eicke Latz; Brian G Monks; D A Schwartz; K Miyake; Douglas T Golenbock
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
The Journal of experimental medicine 2001;194(1):79-88.
2001: Holger Heine; Artur J Ulmer; Volker El-Samalouti; Arnd Lentschat; Lutz Hamann
Decay-accelerating factor (DAF/CD55) is a functional active element of the LPS receptor complex.
Journal of endotoxin research 2001;7(3):227-31.
2000: Egil Lien; TK Means; Holger Heine; A Yoshimura; Shoichi Kusumoto; Koichi Fukase; Matthew J Fenton; Masato Oikawa; N Qureshi; Brian G Monks; R W Finberg; Robin R Ingalls; Douglas T Golenbock
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
The Journal of clinical investigation 2000;105(4):497-504.
1999: Holger Heine; RL Delude; Brian G Monks; Terje Espevik; Douglas T Golenbock
Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.
The Journal of biological chemistry 1999;274(30):21049-55.
1999: Holger Heine; C J Kirschning; Egil Lien; Brian G Monks; M Rothe; Douglas T Golenbock
Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):6971-5.
1999: Robin R Ingalls; Holger Heine; Egil Lien; A Yoshimura; Douglas T Golenbock
Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.
Infectious disease clinics of North America 1999;13(2):341-53, vii.
1998: Sunna Hauschildt; A J Ulmer; Hans-Dieter Flad; T Heyden; Holger Heine
ADP-ribosylation: role in LPS-induced phosphorylation of two cytosolic proteins (p36/38) in monocytes.
Progress in clinical and biological research 1998;397():147-55.
1997: Sunna Hauschildt; C Schwarz; Holger Heine; A J Ulmer; Hans-Dieter Flad; E T Rietschel; O N Jensen; M Mann
Actin: a target of lipopolysaccharide-induced phosphorylation in human monocytes.
Biochemical and biophysical research communications 1997;241(3):670-4.
1997: Sunna Hauschildt; P Scheipers; W Bessler; K Schwarz; A Ullmer; Hans-Dieter Flad; Holger Heine
Role of ADP-ribosylation in activated monocytes/macrophages.
Advances in experimental medicine and biology 1997;419():249-52.
1996: Ernst Th Rietschel; Helmut Brade; Otto Holst; Lore Brade; Sven Müller-Loennies; Uwe Mamat; Ulrich Zähringer; F Beckmann; Ulrich Seydel; Klaus Brandenburg; Artur J Ulmer; T Mattern; Holger Heine; J Schletter; Harald Loppnow; Uwe Schönbeck; Hans-Dieter Flad; Sunna Hauschildt; U F Schade; F Di Padova; S Kusumoto; Ralf R Schumann
Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.
Current topics in microbiology and immunology 1996;216():39-81.
1995: J Schletter; Holger Heine; Artur J Ulmer; Ernst Th Rietschel
Molecular mechanisms of endotoxin activity.
Archives of microbiology 1995;164(6):383-9.
1995: Holger Heine; Artur J Ulmer; Hans-Dieter Flad; Sunna Hauschildt
Lipopolysaccharide-induced change of phosphorylation of two cytosolic proteins in human monocytes is prevented by inhibitors of ADP-ribosylation.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4899-908.
1994: Artur J Ulmer; Holger Heine; W Feist; M H Wang; Harald Loppnow; Teruo Kirikae; Fumiko Kirikae; S Kusumoto; T Kusama; Helmut Brade
Biological activity of lipid A partial structures.
Progress in clinical and biological research 1994;388():71-83.
1992: Artur J Ulmer; W Feist; Holger Heine; Teruo Kirikae; Fumiko Kirikae; S Kusumoto; T Kusama; Helmut Brade; U Schade; Ernst Th Rietschel
Modulation of endotoxin-induced monokine release in human monocytes by lipid A partial structures that inhibit binding of 125I-lipopolysaccharide.
Infection and immunity 1992;60(12):5145-52.
1992: Artur J Ulmer; Holger Heine; W Feist; S Kusumoto; T Kusama; Helmut Brade; U Schade; Ernst Th Rietschel; Hans-Dieter Flad
Biological activity of synthetic phosphonooxyethyl analogs of lipid A and lipid A partial structures.
Infection and immunity 1992;60(8):3309-14.