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Kevin Bunting

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Jinwei Du; Sally L Dunwoodie; Xiangzi Han; Qiang Li; Zhengqi Wang; Kevin D Bunting; Yu Chen; Cindy Cheng; David Danielpour; Yu-Chung Yang
HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency.
Nicholas A Pullen; Brian O Barnstein; Kevin D Bunting; Petr Draber; Yves T Falanga; Emily A Harry; Michele C Khurana; Kazuya Mizuno; Ryo Suzuki; Tenchee D Lama Tamang; Zhengqi Wang; Bridget S Wilson; John J Ryan
Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.
Zhuoming Liu; Amy Yang; Zhengqi Wang; Kevin D Bunting; Gangarao Davuluri; Michael R Green; Laxminarayana R Devireddy
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.

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2012: Jinwei Du; Sally L Dunwoodie; Xiangzi Han; Qiang Li; Zhengqi Wang; Kevin D Bunting; Yu Chen; Cindy Cheng; David Danielpour; Yu-Chung Yang
HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency.
Blood 2012;119(12):2789-98.
2012: Nicholas A Pullen; Brian O Barnstein; Kevin D Bunting; Petr Draber; Yves T Falanga; Emily A Harry; Michele C Khurana; Kazuya Mizuno; Ryo Suzuki; Tenchee D Lama Tamang; Zhengqi Wang; Bridget S Wilson; John J Ryan
Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.
The Journal of biological chemistry 2012;287(3):2045-54.
2011: Zhuoming Liu; Amy Yang; Zhengqi Wang; Kevin D Bunting; Gangarao Davuluri; Michael R Green; Laxminarayana R Devireddy
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.
The Journal of biological chemistry 2011;286(23):20606-14.
2010: Dan Xu; Siying Wang; Wen-Mei Yu; Gordon Chan; Toshiyuki Araki; Kevin D Bunting; Benjamin G Neel; Cheng-Kui Qu
A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
Blood 2010;116(18):3611-21.
2010: Geqiang Li; K L Miskimen; Zuncai Wang; X Y Xie; William Tse; F Gouilleux; Richard Moriggl; Kevin D Bunting
Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin.
Leukemia 2010;24(8):1397-405.
2010: Geqiang Li; Kristy L Miskimen; Zhengqi Wang; Xiu Yan Xie; Jennifer Brenzovich; John J Ryan; William Tse; Richard Moriggl; Kevin D Bunting
STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.
Blood 2010;115(7):1416-24.
2010: Geqiang Li; Zhengqi Wang; Kristy L Miskimen; Yi Zhang; William Tse; Kevin D Bunting
Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.
PloS one 2010;5(2):e9152.
2009: Zhengqi Wang; Geqiang Li; William Tse; Kevin D Bunting
Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.
Blood 2009;113(20):4856-65.
2009: E Ricky Chan; Heather Lavender; Geqiang Li; Peter Haviernik; Kevin D Bunting; Mark D Adams
An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance.
Experimental hematology 2009;37(2):276-84.
2009: Kevin D Bunting
CLPs find their inner T-cell potential.
Blood 2009;113(4):766-7.
2008: Peter Haviernik; Maria T Diaz; Eleonora Haviernikova; William Tse; William Stetler-Stevenson; Kevin D Bunting
Hematopoiesis in mice is extremely resilient to wide variation in TIMP/MMP balance.
Blood cells, molecules & diseases 2008;41(2):179-87.
2008: Peter Haviernik; Yi Zhang; Kevin D Bunting
Retroviral transduction of murine hematopoietic stem cells.
Methods in molecular biology (Clifton, N.J.) 2008;430():229-41.
2008: Zhengqi Wang; Kevin D Bunting
Hematopoietic stem cell transplant into non-myeloablated W/Wv mice to detect steady-state engraftment defects.
Methods in molecular biology (Clifton, N.J.) 2008;430():171-81.
2008: William Tse; Kevin D Bunting
The expanding tool kit for hematopoietic stem cell research.
Methods in molecular biology (Clifton, N.J.) 2008;430():3-18.
2007: Geqiang Li; Zhengqi Wang; Yi Zhang; Zizhen Kang; Eleonora Haviernikova; Yongzhi Cui; Lothar Hennighausen; Richard Moriggl; Demin Wang; William Tse; Kevin D Bunting
STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.
Experimental hematology 2007;35(11):1684-94.
2007: Radina P Soebiyanto; Sree N Sreenath; Cheng-Kui Qu; Kenneth A Loparo; Kevin D Bunting
Complex systems biology approach to understanding coordination of JAK-STAT signaling.
Bio Systems 2007;90(3):830-42.
2007: Yu Chen; Peter Haviernik; Kevin D Bunting; Yu-Chung Yang
Cited2 is required for normal hematopoiesis in the murine fetal liver.
Blood 2007;110(8):2889-98.
2007: Yi Zhang; Ernesto Diaz-Flores; Geqiang Li; Zhengqi Wang; Zizhen Kang; Eleonora Haviernikova; Sara Rowe; Cheng-Kui Qu; William Tse; Kevin Shannon; Kevin D Bunting
Abnormal hematopoiesis in Gab2 mutant mice.
Blood 2007;110(1):116-24.
2007: Sigrid Eckardt; N Adrian Leu; Heath L Bradley; Hiromi Kato; Kevin D Bunting; K John McLaughlin
Hematopoietic reconstitution with androgenetic and gynogenetic stem cells.
Genes & development 2007;21(4):409-19.
2007: Kevin D Bunting
STAT5 signaling in normal and pathologic hematopoiesis.
Frontiers in bioscience : a journal and virtual library 2007;12():2807-20.
2006: Brian O Barnstein; Geqiang Li; Zhengqi Wang; Sarah Kennedy; Charles E Chalfant; Hiroshi Nakajima; Kevin D Bunting; John J Ryan
Stat5 expression is required for IgE-mediated mast cell function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3421-6.
2006: Wen-Mei Yu; Hanako Daino; Jing Chen; Kevin D Bunting; Cheng-Kui Qu
Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling.
The Journal of biological chemistry 2006;281(9):5426-34.
2006: Biying Xu; Peter Haviernik; Lawrence A Wolfraim; Kevin D Bunting; David W Scott
Bone marrow transplantation combined with gene therapy to induce antigen-specific tolerance and ameliorate EAE.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(1):42-8.
2005: Christine Couldrey; Heath L Bradley; Kevin D Bunting
A STAT5 modifier locus on murine chromosome 7 modulates engraftment of hematopoietic stem cells during steady-state hematopoiesis.
Blood 2005;105(4):1476-83.
2005: Richard Moriggl; Veronika Sexl; Lukas Kenner; Christopher D Duntsch; Katharina Stangl; Suzanne Gingras; Angelika Hoffmeyer; anton bauer; Roland P Piekorz; Demin Wang; Kevin D Bunting; Erwin F Wagner; Karoline Sonneck; Peter Valent; James N Ihle; Hartmut Beug
Stat5 tetramer formation is associated with leukemogenesis.
Cancer cell 2005;7(1):87-99.
2004: Peter Haviernik; Carisa Lahoda; Heath L Bradley; Teresa S Hawley; Ali Ramezani; Robert G Hawley; Maryalice Stetler-Stevenson; William Stetler-Stevenson; Kevin D Bunting
Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiation.
Oncogene 2004;23(57):9212-9.
2004: Peter Haviernik; Kevin D Bunting
Safety concerns related to hematopoietic stem cell gene transfer using retroviral vectors.
Current gene therapy 2004;4(3):263-76.
2004: Kevin D Bunting; Wen-Mei Yu; Heath L Bradley; Eleonora Haviernikova; Ann E Kelly-Welch; Achsah D Keegan; Cheng-Kui Qu
Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression.
Journal of leukocyte biology 2004;76(2):484-90.
2004: Jing Chen; Wen-Mei Yu; Kevin D Bunting; Cheng-Kui Qu
A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival.
Oncogene 2004;23(20):3659-69.
2004: Heath L Bradley; Christine Couldrey; Kevin D Bunting
Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness.
Blood 2004;103(8):2965-72.
2003: Christopher P Shelburne; Margaret McCoy; Roland P Piekorz; Veronika Sexl; Kwan-Ho Roh; Sarah Helber; Sheila R Gillespie; Daniel P Bailey; Paria Mirmonsef; Meredith N Mann; Mohit Kashyap; Harry V Wright; Hey Jin Chong; L Andrew Bouton; Brian O Barnstein; Carlos D Ramirez; Kevin D Bunting; Steven Sawyer; Chris S Lantz; John J Ryan
Stat5 expression is critical for mast cell development and survival.
Blood 2003;102(4):1290-7.
2002: Heath L Bradley; Teresa S Hawley; Kevin D Bunting
Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.
Blood 2002;100(12):3983-9.
2002: Kevin D Bunting; Heath L Bradley; Teresa S Hawley; Richard Moriggl; Brian P Sorrentino; James N Ihle
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.
Blood 2002;99(2):479-87.
2002: Kevin D Bunting
ABC transporters as phenotypic markers and functional regulators of stem cells.
Stem cells (Dayton, Ohio) 2002;20(1):11-20.
2001: S Zhou; John D Schuetz; Kevin D Bunting; A M Colapietro; Janardhan Sampath; J J Morris; Irina Lagutina; Gerard C Grosveld; M Osawa; H Nakauchi; Brian P Sorrentino
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype.
Nature medicine 2001;7(9):1028-34.
2001: Alan J Townsend; Sandra Leone-Kabler; RL Haynes; Y Wu; Luke I Szweda; Kevin D Bunting
Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells.
Chemico-biological interactions 2001;130-132(1-3):261-73.
2001: Renren Wen; Denan Wang; Catriona McKay; Kevin D Bunting; Jean-Christophe Marine; E F Vanin; Gerard P Zambetti; Stanley J Korsmeyer; James N Ihle; John L Cleveland
Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development.
Molecular and cellular biology 2001;21(2):678-89.
2000: Kevin D Bunting; T Lu; P F Kelly; Brian P Sorrentino
Self-selection by genetically modified committed lymphocyte precursors reverses the phenotype of JAK3-deficient mice without myeloablation.
Human gene therapy 2000;11(17):2353-64.
2000: Veronika Sexl; Roland P Piekorz; Richard Moriggl; J Rohrer; M P Brown; Kevin D Bunting; K Rothammer; Martine F Roussel; James N Ihle
Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5.
Blood 2000;96(6):2277-83.
2000: Kevin D Bunting; Sheng Zhou; T Lu; Brian P Sorrentino
Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo.
Blood 2000;96(3):902-9.
1999: Kevin D Bunting; Jacques Galipeau; David J Topham; Ely Benaim; Brian P Sorrentino
Effects of retroviral-mediated MDR1 expression on hematopoietic stem cell self-renewal and differentiation in culture.
Annals of the New York Academy of Sciences 1999;872():125-40; discussion 140-1.
1999: Richard Moriggl; David J Topham; S Teglund; Veronika Sexl; Catriona McKay; Denan Wang; Angelika Hoffmeyer; Jan M A van Deursen; Mark Y Sangster; Kevin D Bunting; Gerard C Grosveld; James N Ihle
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
Immunity 1999;10(2):249-59.
1999: Kevin D Bunting; KJ Flynn; Janice M Riberdy; Peter C Doherty; Brian P Sorrentino
Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):232-7.
1998: Kevin D Bunting; Jacques Galipeau; David J Topham; Ely Benaim; Brian P Sorrentino
Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice.
Blood 1998;92(7):2269-79.
1998: Kevin D Bunting; Alan J Townsend
Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein.
Biochemical pharmacology 1998;56(1):31-9.
1998: Kevin D Bunting; Mark Y Sangster; James N Ihle; Brian P Sorrentino
Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer.
Nature medicine 1998;4(1):58-64.
1997: Kevin D Bunting; M Webb; F Giorgianni; Jacques Galipeau; RL Blakley; Alan J Townsend; Brian P Sorrentino
Coding region-specific destabilization of mRNA transcripts attenuates expression from retroviral vectors containing class 1 aldehyde dehydrogenase cDNAs.
Human gene therapy 1997;8(13):1531-43.
1996: Kevin D Bunting; Alan J Townsend
Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme.
The Journal of biological chemistry 1996;271(20):11891-6.
1996: Kevin D Bunting; Alan J Townsend
De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.
The Journal of biological chemistry 1996;271(20):11884-90.
1994: Kevin D Bunting; R Lindahl; Alan J Townsend
Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase.
The Journal of biological chemistry 1994;269(37):23197-203.